1 PIRSR000005-1 Domain

PIRSF000005 Bacteria

SRHMM000005-1 FTGRP_1 SRHMM000005-1 FTGRP_2 SRHMM000005-1 FTGRP_3 SRHMM000005-1 FTGRP_4 Heme Binds 2 heme groups per subunit. SRHMM000005-1 C Heme 1; covalent SRHMM000005-1 C Heme 2; covalent SRHMM000005-1 C Heme 1; covalent SRHMM000005-1 C Heme 2; covalent 1 PIRSR000005-2 Domain

PIRSF000005 Bacteria

SRHMM000005-2 FTGRP_1 SRHMM000005-2 FTGRP_2 SRHMM000005-2 FTGRP_3 SRHMM000005-2 FTGRP_4 Iron Metal-binding SRHMM000005-2 H Iron (heme 1 axial ligand) SRHMM000005-2 M Iron (heme 2 axial ligand) SRHMM000005-2 H Iron (heme 2 axial ligand) SRHMM000005-2 M Iron (heme 1 axial ligand) 1 PIRSR000006-1 Domain

PIRSF000006 Bacteria

SRHMM000006-1 FTGRP_1 Iron Metal-binding SRHMM000006-1 H Iron (heme C 1 axial ligand) M Iron (heme C 2 axial ligand) H Iron (heme C 2 axial ligand) M Iron (heme C 1 axial ligand) 1 PIRSR000006-2 Domain

PIRSF000006 Bacteria

SRHMM000006-2 FTGRP_1 SRHMM000006-2 FTGRP_2 SRHMM000006-2 FTGRP_3 SRHMM000006-2 FTGRP_4 Heme heme c Binds 2 heme C groups per subunit. SRHMM000006-2 C Heme C 1; covalent SRHMM000006-2 C Heme C 2; covalent SRHMM000006-2 C Heme C 1; covalent SRHMM000006-2 C Heme C 2; covalent 1 PIRSR000007-50 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF000007 Bacteria

SRHMM000007-50 FTGRP_1 Heme Binds 2 heme groups covalently per subunit. SRHMM000007-50 C Heme 1 (covalent) C Heme 1 (covalent) C Heme 2 (covalent) C Heme 2 (covalent) 1 PIRSR000007-51 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF000007 Bacteria

SRHMM000007-51 FTGRP_1 Heme Iron Metal-binding Binds 2 heme groups covalently per subunit. SRHMM000007-51 H Iron (heme 1 axial ligand) H Iron (heme 2 axial ligand) 1 PIRSR000008-1 Domain

PIRSF000008 Bacteria

SRHMM000008-1 FTGRP_1 SRHMM000008-1 FTGRP_2 Heme Binds 1 heme group per subunit. SRHMM000008-1 C Heme; covalent SRHMM000008-1 C Heme; covalent 1 PIRSR000008-2 Domain

PIRSF000008 Bacteria

SRHMM000008-2 FTGRP_1 Iron Metal-binding SRHMM000008-2 H Iron (heme axial ligand) 1 PIRSR000009-1 Domain

PIRSF000009 Bacteria

SRHMM000009-1 FTGRP_1 SRHMM000009-1 FTGRP_2 Heme Binds 1 heme group per subunit. SRHMM000009-1 C Heme; covalent SRHMM000009-1 C Heme; covalent 1 PIRSR000009-2 Domain

PIRSF000009 Bacteria

SRHMM000009-2 FTGRP_1 SRHMM000009-2 FTGRP_2 Iron Metal-binding SRHMM000009-2 H Iron (heme axial ligand) SRHMM000009-2 M Iron (heme axial ligand) 1 PIRSR000013-1 Domain

PIRSF000013 Bacteria

SRHMM000013-1 FTGRP_1 SRHMM000013-1 FTGRP_2 SRHMM000013-1 FTGRP_3 SRHMM000013-1 FTGRP_5 SRHMM000013-1 FTGRP_8 SRHMM000013-1 FTGRP_9 SRHMM000013-1 FTGRP_10 SRHMM000013-1 FTGRP_11 Heme heme Binds 4 heme groups per subunit. SRHMM000013-1 C Heme 1; covalent SRHMM000013-1 C Heme 4; covalent SRHMM000013-1 C Heme 2; covalent SRHMM000013-1 C Heme 4; covalent SRHMM000013-1 C Heme 3; covalent SRHMM000013-1 C Heme 2; covalent SRHMM000013-1 K Substrate SRHMM000013-1 N Substrate SRHMM000013-1 C Heme 3; covalent SRHMM000013-1 C Heme 1; covalent SRHMM000013-1 D Substrate 1 PIRSR000013-2 Domain

PIRSF000013 Bacteria

SRHMM000013-2 FTGRP_1 SRHMM000013-2 FTGRP_2 SRHMM000013-2 FTGRP_3 SRHMM000013-2 FTGRP_4 SRHMM000013-2 FTGRP_5 SRHMM000013-2 FTGRP_6 SRHMM000013-2 FTGRP_7 Iron Metal-binding SRHMM000013-2 M Iron (heme 1 axial ligand) SRHMM000013-2 H Iron (heme 2 axial ligand); via tele nitrogen SRHMM000013-2 H Iron (heme 2 axial ligand); via tele nitrogen SRHMM000013-2 H Iron (heme 3 axial ligand); via tele nitrogen SRHMM000013-2 H Iron (heme 3 axial ligand); via tele nitrogen SRHMM000013-2 H Iron (heme 4 axial ligand); via tele nitrogen SRHMM000013-2 [DE] Iron (heme 1 axial ligand) 1 PIRSR000014-1 Domain

PIRSF000014 Bacteria

SRHMM000014-1 FTGRP_1 SRHMM000014-1 FTGRP_2 SRHMM000014-1 FTGRP_3 SRHMM000014-1 FTGRP_4 SRHMM000014-1 FTGRP_5 SRHMM000014-1 FTGRP_6 SRHMM000014-1 FTGRP_7 SRHMM000014-1 FTGRP_8 SRHMM000014-1 FTGRP_9 SRHMM000014-1 FTGRP_10 Heme Binds 5 heme groups per subunit. SRHMM000014-1 C Heme 1; covalent SRHMM000014-1 C Heme 4; covalent SRHMM000014-1 C Heme 5; covalent SRHMM000014-1 C Heme 5; covalent SRHMM000014-1 C Heme 2; covalent SRHMM000014-1 C Heme 2; covalent SRHMM000014-1 C Heme 4; covalent SRHMM000014-1 C Heme 3; covalent SRHMM000014-1 C Heme 1; covalent SRHMM000014-1 C Heme 3; covalent 1 PIRSR000014-2 Domain

PIRSF000014 Bacteria

SRHMM000014-2 FTGRP_1 SRHMM000014-2 FTGRP_2 SRHMM000014-2 FTGRP_3 SRHMM000014-2 FTGRP_4 SRHMM000014-2 FTGRP_5 Iron SRHMM000014-2 H Iron (heme 2 axial ligand) SRHMM000014-2 H Iron (heme 3 axial ligand) SRHMM000014-2 H Iron (heme 1 axial ligand) SRHMM000014-2 H Iron (heme 4 axial ligand) SRHMM000014-2 H Iron (heme 5 axial ligand) 1 PIRSR000017-1 Domain

PIRSF000017 Bacteria

SRHMM000017-1 FTGRP_1 SRHMM000017-1 FTGRP_2 SRHMM000017-1 FTGRP_3 SRHMM000017-1 FTGRP_4 SRHMM000017-1 FTGRP_5 SRHMM000017-1 FTGRP_6 SRHMM000017-1 FTGRP_7 SRHMM000017-1 FTGRP_8 Heme Binds 4 heme groups per subunit. SRHMM000017-1 C Heme 4; covalent SRHMM000017-1 C Heme 1; covalent SRHMM000017-1 C Heme 4; covalent SRHMM000017-1 C Heme 1; covalent SRHMM000017-1 C Heme 3; covalent SRHMM000017-1 C Heme 3; covalent SRHMM000017-1 C Heme 2; covalent SRHMM000017-1 C Heme 2; covalent 1 PIRSR000017-2 Domain

PIRSF000017 Bacteria

SRHMM000017-2 FTGRP_1 SRHMM000017-2 FTGRP_2 SRHMM000017-2 FTGRP_3 SRHMM000017-2 FTGRP_4 SRHMM000017-2 FTGRP_5 SRHMM000017-2 FTGRP_6 SRHMM000017-2 FTGRP_7 SRHMM000017-2 FTGRP_8 Heme Iron Metal-binding Binds 4 heme groups per subunit. SRHMM000017-2 H Iron (heme 3 axial ligand); via tele nitrogen SRHMM000017-2 H Iron (heme 4 axial ligand); via tele nitrogen SRHMM000017-2 H Iron (heme 4 axial ligand); via tele nitrogen SRHMM000017-2 H Iron (heme 1 axial ligand); via tele nitrogen SRHMM000017-2 H Iron (heme 2 axial ligand); via tele nitrogen SRHMM000017-2 M Iron (heme 3 axial ligand) SRHMM000017-2 M Iron (heme 1 axial ligand) SRHMM000017-2 M Iron (heme 2 axial ligand) 1 PIRSR000018-50 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF000018 Bacteria

SRHMM000018-50 FTGRP_1 Heme Binds 3 heme groups per subunit. SRHMM000018-50 C Heme 1 (covalent) C Heme 1 (covalent) C Heme 2 (covalent) C Heme 2 (covalent) C Heme 3 (covalent) C Heme 3 (covalent) 1 PIRSR000018-51 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF000018 Bacteria

SRHMM000018-51 FTGRP_1 Heme Iron Metal-binding Binds 3 heme groups per subunit. SRHMM000018-51 H Iron (heme 1 axial ligand) H Iron (heme 2 axial ligand) H Iron (heme 3 axial ligand) 1 PIRSR000019-1 Domain

PIRSF000019 Eukaryota

SRHMM000019-1 FTGRP_1 Disulfide bond SRHMM000019-1 C-x(13)-C SRHMM000019-1 C-x(43)-C 1 PIRSR000025-1 Domain

PIRSF000025 Bacteria

SRHMM000025-1 FTGRP_1 SRHMM000025-1 FTGRP_2 Heme Binds 1 heme group per subunit. SRHMM000025-1 C Heme; covalent SRHMM000025-1 C Heme; covalent 1 PIRSR000025-2 Domain

PIRSF000025 Bacteria

SRHMM000025-2 FTGRP_1 SRHMM000025-2 FTGRP_2 Iron Metal-binding SRHMM000025-2 H Iron (heme axial ligand) SRHMM000025-2 M Iron (heme axial ligand) 1 PIRSR000027-1 Domain

PIRSF000027 Bacteria

SRHMM000027-1 FTGRP_1 Metal-binding Iron SRHMM000027-1 H Iron (heme axial ligand) 1 PIRSR000027-2 Domain

PIRSF000027 Bacteria

SRHMM000027-2 FTGRP_1 SRHMM000027-2 FTGRP_2 Heme Binds 1 heme group per subunit. SRHMM000027-2 C Heme; covalent SRHMM000027-2 C Heme; covalent 1 PIRSR000029-1 Domain

PIRSF000029 Bacteria

SRHMM000029-1 FTGRP_1 SRHMM000029-1 FTGRP_2 Heme Iron Metal-binding heme b Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule. SRHMM000029-1 M Iron (heme B axial ligand) SRHMM000029-1 H Iron (heme B axial ligand) 1 PIRSR000047-1 Domain

PIRSF000047 Eukaryota

SRHMM000047-1 FTGRP_1 Heme Iron Metal-binding heme SRHMM000047-1 C Iron (heme axial ligand) 1 PIRSR000047-2 Domain

PIRSF000047 Eukaryota

SRHMM000047-2 [RK] Substrate L Substrate; via amide nitrogen N Substrate [RK] Substrate 1 PIRSR000068-1 Domain

PIRSF000068 Archaea

SRHMM000068-1 FTGRP_4 SRHMM000068-1 FTGRP_5 SRHMM000068-1 FTGRP_11 Metal-binding 3Fe-4S Iron-sulfur Iron [3Fe-4S] cluster Binds 1 [3Fe-4S] cluster. SRHMM000068-1 FTGRP_1 SRHMM000068-1 FTGRP_2 SRHMM000068-1 FTGRP_3 SRHMM000068-1 FTGRP_7 Metal-binding Zinc Zn(2+) Binds 1 zinc ion. SRHMM000068-1 FTGRP_6 SRHMM000068-1 FTGRP_8 SRHMM000068-1 FTGRP_9 SRHMM000068-1 FTGRP_10 Metal-binding 4Fe-4S Iron-sulfur Iron [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. SRHMM000068-1 H Zinc SRHMM000068-1 C Iron-sulfur 1 (3Fe-4S) SRHMM000068-1 C Iron-sulfur 2 (4Fe-4S) SRHMM000068-1 D Zinc SRHMM000068-1 H Zinc SRHMM000068-1 C Iron-sulfur 1 (3Fe-4S) SRHMM000068-1 C Iron-sulfur 1 (3Fe-4S) SRHMM000068-1 C Iron-sulfur 2 (4Fe-4S) SRHMM000068-1 C Iron-sulfur 2 (4Fe-4S) SRHMM000068-1 C Iron-sulfur 2 (4Fe-4S) SRHMM000068-1 H Zinc 1 PIRSR000071-1 Domain

PIRSF000071 Archaea Bacteria

SRHMM000071-1 FTGRP_1 SRHMM000071-1 FTGRP_2 SRHMM000071-1 FTGRP_3 SRHMM000071-1 FTGRP_4 Iron Metal-binding Fe(3+) Binds 1 Fe(3+) ion per subunit. SRHMM000071-1 C Iron SRHMM000071-1 C Iron SRHMM000071-1 C Iron SRHMM000071-1 C Iron 1 PIRSR000075-1 Domain

PIRSF000075 Bacteria Archaea

SRHMM000075-1 FTGRP_1 Iron Metal-binding Fe cation Binds 2 irons ions per subunit via 4 cysteine residues per iron. SRHMM000075-1 C Iron C Iron C Iron C Iron 1 PIRSR000077-4 Domain

PIRSF000077 Eukaryota Bacteria Archaea

SRHMM000077-4 FTGRP_1 Disulfide bond Redox-active center SRHMM000077-4 C-x(2)-C Redox-active 1 PIRSR000084-50 Domain

PIRSF000084 Viridiplantae

SRHMM000084-50 FTGRP_1 Chromophore Contains one covalently linked phytochromobilin chromophore. SRHMM000084-50 C Phytochromobilin chromophore (covalent; via 1 link) 1 PIRSR000087-50 Domain This rule was created based on analysis for RESID:AA0207.

PIRSF000087 Proteobacteria

SRHMM000087-50 FTGRP_1 Chromophore The 4-hydroxycinnamic acid (p-coumaric acid) chromophore is covalently bound via a thioester linkage. SRHMM000087-50 C S-(4-hydroxycinnamyl)cysteine 1 PIRSR000090-1 Domain

PIRSF000090 Eukaryota Bacteria

SRHMM000090-1 A AMP; via carbonyl oxygen N-x(2)-C AMP C AMP; via amide nitrogen and carbonyl oxygen G-x(10)-T AMP 1 PIRSR000094-1 Domain

PIRSF000094 Bacteria

SRHMM000094-1 Y Proton acceptor Y Proton acceptor 1 PIRSR000094-2 Domain

PIRSF000094 Bacteria

SRHMM000094-2 A Substrate; via amide nitrogen and carbonyl oxygen 1 PIRSR000094-3 Domain

PIRSF000094 Bacteria

SRHMM000094-3 FTGRP_1 SRHMM000094-3 FTGRP_2 SRHMM000094-3 FTGRP_3 SRHMM000094-3 FTGRP_4 SRHMM000094-3 FTGRP_5 SRHMM000094-3 FTGRP_6 SRHMM000094-3 FTGRP_7 NAD SRHMM000094-3 D-V NAD SRHMM000094-3 K NAD SRHMM000094-3 [IVML] NAD; via carbonyl oxygen SRHMM000094-3 [IV]-x(3)-[AS] NAD SRHMM000094-3 G NAD; via carbonyl oxygen SRHMM000094-3 Q NAD SRHMM000094-3 S-I NAD 1 PIRSR000094-4 Domain

PIRSF000094 Bacteria

SRHMM000094-4 K Involved in acyl-ACP binding [RKN] Involved in acyl-ACP binding K Involved in acyl-ACP binding 1 PIRSR000095-1 Domain

PIRSF000095 Eukaryota

SRHMM000095-1 Y Proton acceptor 1 PIRSR000095-2 Domain

PIRSF000095 Eukaryota

SRHMM000095-2 G-x(27)-R NADP D NADP S Substrate K NADP 1 PIRSR000097-1 Domain

PIRSF000097 Eukaryota Bacteria

SRHMM000097-1 Y Proton donor 1 PIRSR000097-2 Domain

PIRSF000097 Eukaryota Bacteria

SRHMM000097-2 H Substrate 1 PIRSR000097-3 Domain

PIRSF000097 Eukaryota Bacteria

SRHMM000097-3 K Lowers pKa of active site Tyr 1 PIRSR000098-1 Domain

PIRSF000098 Bacteria

SRHMM000098-1 K Proton donor 1 PIRSR000098-2 Domain

PIRSF000098 Bacteria

SRHMM000098-2 FTGRP_1 SRHMM000098-2 FTGRP_2 NADP SRHMM000098-2 K NADP SRHMM000098-2 [LVIMAC]-G-x-G-x(2)-G-[STGAKC] NADP SRHMM000098-2 E Substrate 1 PIRSR000099-1 Domain

PIRSF000099 Archaea Viridiplantae Fungi Bacteria

SRHMM000099-1 E Proton acceptor H Proton acceptor 1 PIRSR000099-2 Domain

PIRSF000099 Archaea Viridiplantae Fungi Bacteria

SRHMM000099-2 FTGRP_1 NAD SRHMM000099-2 Y NAD Q NAD N NAD 1 PIRSR000099-3 Domain

PIRSF000099 Archaea Viridiplantae Fungi Bacteria

SRHMM000099-3 [ST] Substrate Q Substrate H Substrate H Substrate D Substrate E Substrate H Substrate 1 PIRSR000099-4 Domain

PIRSF000099 Archaea Viridiplantae Fungi Bacteria

SRHMM000099-4 FTGRP_1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM000099-4 [QE] Zinc H Zinc D Zinc H Zinc 1 PIRSR000101-1 Domain

PIRSF000101 Bacteria

SRHMM000101-1 FTGRP_1 SRHMM000101-1 FTGRP_2 SRHMM000101-1 FTGRP_3 SRHMM000101-1 FTGRP_4 SRHMM000101-1 FTGRP_5 SRHMM000101-1 FTGRP_6 SRHMM000101-1 FTGRP_7 FAD FAD SRHMM000101-1 G FAD; via amide nitrogen SRHMM000101-1 A FAD; via amide nitrogen SRHMM000101-1 G-S FAD SRHMM000101-1 A-x-[NK]-T-G FAD SRHMM000101-1 [VLI] FAD; via amide nitrogen and carbonyl oxygen SRHMM000101-1 [ST] FAD SRHMM000101-1 G FAD; via amide nitrogen 1 PIRSR000102-1 Domain

PIRSF000102 Eukaryota Bacteria Archaea

SRHMM000102-1 H Proton acceptor 1 PIRSR000102-2 Domain

PIRSF000102 Eukaryota Bacteria Archaea

SRHMM000102-2 R Substrate N Substrate R Substrate 1 PIRSR000103-1 Domain

PIRSF000103 Eukaryota Bacteria

SRHMM000103-1 K 1 PIRSR000103-2 Domain

PIRSF000103 Eukaryota Bacteria

SRHMM000103-2 FTGRP_1 NAD SRHMM000103-2 T-x(27)-Y NAD L-P NAD N NAD T NAD K NAD 1 PIRSR000105-1 Domain

PIRSF000105 Eukaryota Bacteria Archaea

SRHMM000105-1 H Important for catalytic activity 1 PIRSR000105-2 Domain

PIRSF000105 Archaea Eukaryota Bacteria

SRHMM000105-2 FTGRP_1 NAD SRHMM000105-2 G-x-G-x(2)-G NAD D NAD E NAD K NAD S NAD N NAD K NAD 1 PIRSR000105-3 Domain

PIRSF000105 Eukaryota Bacteria

SRHMM000105-3 S Coenzyme A K Coenzyme A S Coenzyme A 1 PIRSR000106-1 Domain

PIRSF000106 Eukaryota Bacteria

SRHMM000106-1 Y Proton donor K Proton acceptor 1 PIRSR000106-3 Domain

PIRSF000106 Eukaryota Bacteria

SRHMM000106-3 FTGRP_1 SRHMM000106-3 FTGRP_2 SRHMM000106-3 FTGRP_3 Metal-binding Mg(2+) Mn(2+) Divalent metal cations. Prefers magnesium or manganese. SRHMM000106-3 D Divalent metal cation SRHMM000106-3 E Divalent metal cation SRHMM000106-3 D Divalent metal cation 1 PIRSR000108-1 Domain

PIRSF000108 Eukaryota Bacteria

SRHMM000108-1 Y Critical for catalysis K Critical for catalysis 1 PIRSR000108-2 Domain

PIRSF000108 Eukaryota Bacteria

SRHMM000108-2 T Substrate S-x-N-x(3)-R Substrate binding R Substrate R Substrate 1 PIRSR000108-3 Domain

PIRSF000108 Eukaryota Bacteria

SRHMM000108-3 FTGRP_1 Manganese Metal-binding Magnesium Mg(2+) Mn(2+) Binds 1 Mg(2+) or Mn(2+) ion per subunit. SRHMM000108-3 D Magnesium or manganese D Magnesium or manganese 1 PIRSR000108-4 Domain

PIRSF000108 Eukaryota Bacteria

SRHMM000108-4 FTGRP_1 NADP SRHMM000108-4 T-x-T NADP R NADP K NADP G-T-V-x-R-H NADP N NADP; via amide nitrogen and carbonyl oxygen 1 PIRSR000109-1 Domain

PIRSF000109 Eukaryota Bacteria

SRHMM000109-1 K Proton acceptor E Proton donor 1 PIRSR000109-2 Domain

PIRSF000109 Eukaryota Bacteria

SRHMM000109-2 N Substrate S-x-G Substrate binding H-N Substrate binding Y Substrate K Substrate; via amide nitrogen R Substrate R Substrate; shared with dimeric partner H Substrate; shared with dimeric partner 1 PIRSR000109-3 Domain

PIRSF000109 Eukaryota Bacteria

SRHMM000109-3 G-x(4)-G NADP N-x-[ST] NADP [VI]-x-[AG] NADP N NADP 1 PIRSR000112-1 Domain

PIRSF000112 Archaea Bacteria

SRHMM000112-1 FTGRP_1 SRHMM000112-1 FTGRP_2 SRHMM000112-1 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM000112-1 [DE] Zinc; catalytic SRHMM000112-1 H Zinc; catalytic SRHMM000112-1 H Zinc; catalytic 1 PIRSR000112-2 Domain

PIRSF000112 Archaea Bacteria

SRHMM000112-2 D Substrate [DE] Substrate H Substrate H Substrate 1 PIRSR000112-3 Domain

PIRSF000112 Archaea Bacteria

SRHMM000112-3 FTGRP_1 SRHMM000112-3 FTGRP_2 SRHMM000112-3 FTGRP_3 SRHMM000112-3 FTGRP_4 SRHMM000112-3 FTGRP_5 SRHMM000112-3 FTGRP_6 NAD SRHMM000112-3 G-x(3)-D NAD SRHMM000112-3 [ST] NAD SRHMM000112-3 D NAD SRHMM000112-3 L NAD; via carbonyl oxygen SRHMM000112-3 T-x(2)-S NAD SRHMM000112-3 Y NAD 1 PIRSR000114-1 Domain

PIRSF000114 Archaea Eukaryota Bacteria

SRHMM000114-1 K Proton acceptor 1 PIRSR000114-2 Domain

PIRSF000114 Archaea Eukaryota Bacteria

SRHMM000114-2 K Substrate R-N Substrate binding 1 PIRSR000114-3 Domain

PIRSF000114 Archaea Eukaryota Bacteria

SRHMM000114-3 FTGRP_1 SRHMM000114-3 FTGRP_2 SRHMM000114-3 FTGRP_3 SRHMM000114-3 FTGRP_4 SRHMM000114-3 FTGRP_5 SRHMM000114-3 FTGRP_6 SRHMM000114-3 FTGRP_7 NAD SRHMM000114-3 F NAD SRHMM000114-3 A NAD; via amide nitrogen SRHMM000114-3 R NAD SRHMM000114-3 Q NAD SRHMM000114-3 G-x-G-x(2)-G NAD SRHMM000114-3 K NAD; via amide nitrogen SRHMM000114-3 F NAD 1 PIRSR000118-1 Domain

PIRSF000118 Eukaryota

SRHMM000118-1 H 1 PIRSR000118-2 Domain

PIRSF000118 Eukaryota

SRHMM000118-2 FTGRP_1 SRHMM000118-2 FTGRP_2 Magnesium Metal-binding SRHMM000118-2 E Magnesium 1 SRHMM000118-2 D Magnesium 1 D Magnesium 2 1 PIRSR000118-3 Domain

PIRSF000118 Eukaryota Bacteria

SRHMM000118-3 FTGRP_1 Magnesium Metal-binding SRHMM000118-3 D Magnesium 2 1 PIRSR000127-1 Domain

PIRSF000127 Eukaryota

SRHMM000127-1 E Proton acceptor 1 PIRSR000127-2 Domain

PIRSF000127 Eukaryota

SRHMM000127-2 FTGRP_1 SRHMM000127-2 FTGRP_2 SRHMM000127-2 FTGRP_3 SRHMM000127-2 FTGRP_4 SRHMM000127-2 FTGRP_5 SRHMM000127-2 FTGRP_6 FAD FAD SRHMM000127-2 [LIV]-x(6)-[ILV] FAD SRHMM000127-2 D FAD SRHMM000127-2 E Substrate R Substrate F Substrate T Substrate; via amide nitrogen SRHMM000127-2 L FAD; via amide nitrogen and carbonyl oxygen SRHMM000127-2 S-x(3)-N FAD SRHMM000127-2 F FAD SRHMM000127-2 [KR] FAD 1 PIRSR000127-3 Domain

PIRSF000127 Eukaryota

SRHMM000127-3 FTGRP_9 SRHMM000127-3 FTGRP_10 SRHMM000127-3 FTGRP_11 SRHMM000127-3 FTGRP_12 Molybdenum Mo-molybdopterin Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. SRHMM000127-3 FTGRP_1 SRHMM000127-3 FTGRP_2 SRHMM000127-3 FTGRP_3 SRHMM000127-3 FTGRP_4 SRHMM000127-3 FTGRP_5 SRHMM000127-3 FTGRP_6 SRHMM000127-3 FTGRP_7 SRHMM000127-3 FTGRP_8 2Fe-2S Iron Iron-sulfur [2Fe-2S] cluster Binds 2 [2Fe-2S] clusters. SRHMM000127-3 FTGRP_1 SRHMM000127-3 FTGRP_2 SRHMM000127-3 FTGRP_3 SRHMM000127-3 FTGRP_4 SRHMM000127-3 FTGRP_5 SRHMM000127-3 FTGRP_6 SRHMM000127-3 FTGRP_7 SRHMM000127-3 FTGRP_8 SRHMM000127-3 FTGRP_9 SRHMM000127-3 FTGRP_10 SRHMM000127-3 FTGRP_11 SRHMM000127-3 FTGRP_12 Metal-binding SRHMM000127-3 C Iron-sulfur 2 SRHMM000127-3 C Iron-sulfur 1 SRHMM000127-3 C Iron-sulfur 1 SRHMM000127-3 C Iron-sulfur 2 SRHMM000127-3 F Molybdenum; via carbonyl oxygen SRHMM000127-3 Q Molybdenum SRHMM000127-3 C Iron-sulfur 1 SRHMM000127-3 C Iron-sulfur 2 SRHMM000127-3 C Iron-sulfur 1 SRHMM000127-3 C Iron-sulfur 2 SRHMM000127-3 [AG] Molybdenum; via amide nitrogen SRHMM000127-3 R Molybdenum; via amide nitrogen 1 PIRSR000130-1 Domain

PIRSF000130 Eukaryota Bacteria Archaea

SRHMM000130-1 C Thioimidate intermediate R Proton acceptor 1 PIRSR000130-2 Domain

PIRSF000130 Eukaryota Bacteria Archaea

SRHMM000130-2 S IMP D-x-G IMP binding G-S IMP binding Y-x(3)-G IMP binding E IMP 1 PIRSR000130-3 Domain

PIRSF000130 Eukaryota Bacteria Archaea

SRHMM000130-3 FTGRP_1 SRHMM000130-3 FTGRP_2 NAD SRHMM000130-3 D-x-[SA] NAD SRHMM000130-3 G-x-G NAD 1 PIRSR000130-4 Domain

PIRSF000130 Eukaryota Bacteria Archaea

SRHMM000130-4 FTGRP_1 SRHMM000130-4 FTGRP_2 SRHMM000130-4 FTGRP_3 Potassium SRHMM000130-4 G Potassium; via carbonyl oxygen SRHMM000130-4 C Potassium; via carbonyl oxygen SRHMM000130-4 G Potassium; via carbonyl oxygen 1 PIRSR000137-1 Domain

PIRSF000137 Eukaryota Bacteria

SRHMM000137-1 H Proton donor H Proton acceptor 1 PIRSR000137-2 Domain

PIRSF000137 Eukaryota Bacteria

SRHMM000137-2 FTGRP_1 SRHMM000137-2 FTGRP_2 SRHMM000137-2 FTGRP_3 SRHMM000137-2 FTGRP_4 SRHMM000137-2 FTGRP_5 SRHMM000137-2 FTGRP_6 SRHMM000137-2 FTGRP_8 SRHMM000137-2 FTGRP_9 SRHMM000137-2 FTGRP_10 FAD FAD SRHMM000137-2 E-R FAD SRHMM000137-2 T-[ST] FAD SRHMM000137-2 N-x(2)-V FAD SRHMM000137-2 V FAD; via amide nitrogen and carbonyl oxygen SRHMM000137-2 W-H FAD SRHMM000137-2 G FAD; via amide nitrogen SRHMM000137-2 V FAD; via carbonyl oxygen SRHMM000137-2 P-Q FAD SRHMM000137-2 C Substrate Y Substrate SRHMM000137-2 T FAD 1 PIRSR000137-3 Domain

PIRSF000137 Eukaryota Bacteria

SRHMM000137-3 FTGRP_1 Disulfide bond SRHMM000137-3 C-x(50)-C 1 PIRSR000138-1 Domain

PIRSF000138 Eukaryota Bacteria

SRHMM000138-1 H Proton acceptor 1 PIRSR000138-2 Domain

PIRSF000138 Eukaryota Bacteria

SRHMM000138-2 FTGRP_2 SRHMM000138-2 FTGRP_3 SRHMM000138-2 FTGRP_4 SRHMM000138-2 FTGRP_6 SRHMM000138-2 FTGRP_8 SRHMM000138-2 FTGRP_9 SRHMM000138-2 FTGRP_11 SRHMM000138-2 FTGRP_12 FMN FMN SRHMM000138-2 D-x(3)-R FMN SRHMM000138-2 R FMN SRHMM000138-2 R Substrate SRHMM000138-2 Q FMN SRHMM000138-2 K FMN SRHMM000138-2 Y Substrate SRHMM000138-2 T FMN SRHMM000138-2 Q FMN SRHMM000138-2 Y Substrate SRHMM000138-2 S FMN SRHMM000138-2 S FMN SRHMM000138-2 R Substrate 1 PIRSR000149-1 Domain

PIRSF000149 Archaea Eukaryota Bacteria

SRHMM000149-1 C Nucleophile 1 PIRSR000149-2 Domain

PIRSF000149 Eukaryota Bacteria Archaea

SRHMM000149-2 S-x-T Glyceraldehyde 3-phosphate binding T Glyceraldehyde 3-phosphate T-G Glyceraldehyde 3-phosphate binding R Glyceraldehyde 3-phosphate 1 PIRSR000149-3 Domain

PIRSF000149 Eukaryota Bacteria Archaea

SRHMM000149-3 FTGRP_1 SRHMM000149-3 FTGRP_2 SRHMM000149-3 FTGRP_3 SRHMM000149-3 FTGRP_4 SRHMM000149-3 FTGRP_5 NAD Nucleotide-binding SRHMM000149-3 R-I NAD SRHMM000149-3 R NAD; via carbonyl oxygen SRHMM000149-3 N NAD SRHMM000149-3 D NAD SRHMM000149-3 [TS] NAD 1 PIRSR000149-4 Domain

PIRSF000149 Archaea Eukaryota Bacteria

SRHMM000149-4 H Activates thiol group during catalysis 1 PIRSR000156-1 Domain

PIRSF000156 Bacteria

SRHMM000156-1 FTGRP_1 SRHMM000156-1 FTGRP_2 SRHMM000156-1 FTGRP_3 Magnesium Metal-binding Mg(2+) SRHMM000156-1 N Magnesium SRHMM000156-1 Q Magnesium; via carbonyl oxygen SRHMM000156-1 D Magnesium 1 PIRSR000159-1 Domain

PIRSF000159 Bacteria

SRHMM000159-1 T Pyruvate E Thiamine pyrophosphate R Pyruvate E Thiamine pyrophosphate C Thiamine pyrophosphate G-x(2)-W Thiamine pyrophosphate binding T-x(4)-N Thiamine pyrophosphate binding 1 PIRSR000159-2 Domain

PIRSF000159 Bacteria

SRHMM000159-2 T Important for catalytic activity E Important for catalytic activity R Important for catalytic activity N Important for catalytic activity 1 PIRSR000159-50 Domain This rule was created based on analysis for RESID:AA0140.

PIRSF000159 Eukaryota Bacteria

SRHMM000159-50 FTGRP_1 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 3 [4Fe-4S] clusters per subunit. SRHMM000159-50 C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) 1 PIRSR000167-1 Domain

PIRSF000167 Bacteria

SRHMM000167-1 FTGRP_1 SRHMM000167-1 FTGRP_2 SRHMM000167-1 FTGRP_3 SRHMM000167-1 FTGRP_4 SRHMM000167-1 FTGRP_5 SRHMM000167-1 FTGRP_6 SRHMM000167-1 FTGRP_7 SRHMM000167-1 FTGRP_8 S-adenosyl-L-methionine SRHMM000167-1 G-[TS] S-adenosyl-L-methionine 2 binding SRHMM000167-1 Y S-adenosyl-L-methionine 1 SRHMM000167-1 D S-adenosyl-L-methionine 2 SRHMM000167-1 R S-adenosyl-L-methionine 2 SRHMM000167-1 [FY] S-adenosyl-L-methionine 2; via carbonyl oxygen SRHMM000167-1 G S-adenosyl-L-methionine 1; via amide nitrogen and carbonyl oxygen SRHMM000167-1 Q S-adenosyl-L-methionine 2 SRHMM000167-1 E S-adenosyl-L-methionine 1 1 PIRSR000167-2 Domain

PIRSF000167 Bacteria

SRHMM000167-2 FTGRP_1 SRHMM000167-2 FTGRP_2 SRHMM000167-2 FTGRP_3 4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. SRHMM000167-2 C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM000167-2 C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM000167-2 C Iron-sulfur (4Fe-4S-S-AdoMet) 1 PIRSR000168-1 Domain

PIRSF000168 Eukaryota

SRHMM000168-1 E Proton acceptor 1 PIRSR000168-2 Domain

PIRSF000168 Eukaryota

SRHMM000168-2 FTGRP_1 SRHMM000168-2 FTGRP_2 FAD SRHMM000168-2 T FAD SRHMM000168-2 G FAD; via amide nitrogen 1 PIRSR000169-1 Domain

PIRSF000169 Bacteria

SRHMM000169-1 Y Ubiquinone 1 PIRSR000169-2 Domain

PIRSF000169 Bacteria

SRHMM000169-2 FTGRP_1 Heme Iron Metal-binding heme The heme is bound between the two transmembrane subunits. SRHMM000169-2 H Iron (heme axial ligand); shared with second transmembrane subunit 1 PIRSR000177-1 Domain

PIRSF000177 Bacteria

SRHMM000177-1 FTGRP_1 Heme Iron Metal-binding SRHMM000177-1 H Iron (heme axial ligand) H Iron (heme axial ligand) H Iron (heme axial ligand) H Iron (heme axial ligand) 1 PIRSR000178-1 Domain

PIRSF000178 Eukaryota Bacteria

SRHMM000178-1 FTGRP_1 Heme Iron Metal-binding heme The heme is bound between the two transmembrane subunits. SRHMM000178-1 H Iron (heme axial ligand); shared with second transmembrane subunit 1 PIRSR000183-1 Domain

PIRSF000183 Bacteria

SRHMM000183-1 H Proton donor/acceptor D Proton donor/acceptor 1 PIRSR000183-2 Domain

PIRSF000183 Bacteria

SRHMM000183-2 R Substrate K Substrate 1 PIRSR000183-3 Domain

PIRSF000183 Bacteria

SRHMM000183-3 FTGRP_1 SRHMM000183-3 FTGRP_2 SRHMM000183-3 FTGRP_3 SRHMM000183-3 FTGRP_4 SRHMM000183-3 FTGRP_5 SRHMM000183-3 FTGRP_6 SRHMM000183-3 FTGRP_7 SRHMM000183-3 FTGRP_8 SRHMM000183-3 FTGRP_9 NAD Nucleotide-binding SRHMM000183-3 D NAD SRHMM000183-3 T-A NAD SRHMM000183-3 [KR] NAD SRHMM000183-3 S NAD SRHMM000183-3 V-x(2)-M NAD SRHMM000183-3 [VI]-L NAD SRHMM000183-3 S NAD SRHMM000183-3 [IV]-x(2)-D NAD SRHMM000183-3 R NAD 1 PIRSR000183-4 Domain

PIRSF000183 Bacteria

SRHMM000183-4 FTGRP_1 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM000183-4 H Magnesium; via tele nitrogen SRHMM000183-4 E Magnesium 1 PIRSR000185-1 Domain

PIRSF000185 Archaea Eukaryota Bacteria

SRHMM000185-1 K Proton donor 1 PIRSR000185-2 Domain

PIRSF000185 Eukaryota Bacteria Archaea

SRHMM000185-2 FTGRP_2 SRHMM000185-2 FTGRP_3 NAD Nucleotide-binding SRHMM000185-2 N NAD SRHMM000185-2 T NAD SRHMM000185-2 K Substrate Q Substrate K Substrate G Substrate; via carbonyl oxygen S Substrate 1 PIRSR000185-3 Domain

PIRSF000185 Eukaryota Bacteria Archaea

SRHMM000185-3 D Important for catalysis 1 PIRSR000187-1 Domain

PIRSF000187 Eukaryota

SRHMM000187-1 C For GATase activity 1 PIRSR000187-2 Domain

PIRSF000187 Eukaryota

SRHMM000187-2 FTGRP_1 SRHMM000187-2 FTGRP_2 SRHMM000187-2 FTGRP_3 3Fe-4S Iron-sulfur [3Fe-4S] cluster Binds 1 [3Fe-4S] cluster. SRHMM000187-2 C Iron-sulfur (3Fe-4S) SRHMM000187-2 C Iron-sulfur (3Fe-4S) SRHMM000187-2 C Iron-sulfur (3Fe-4S) 1 PIRSR000188-1 Domain

PIRSF000188 Bacteria Archaea

SRHMM000188-1 K Proton donor/acceptor 1 PIRSR000188-2 Domain

PIRSF000188 Bacteria

SRHMM000188-2 FTGRP_1 NAD Nucleotide-binding SRHMM000188-2 G-x(4)-[GA] NAD 1 PIRSR000189-1 Domain

PIRSF000189 Eukaryota Bacteria

SRHMM000189-1 FTGRP_1 SRHMM000189-1 FTGRP_2 SRHMM000189-1 FTGRP_3 SRHMM000189-1 FTGRP_5 SRHMM000189-1 FTGRP_6 SRHMM000189-1 FTGRP_7 FAD FAD SRHMM000189-1 D-R FAD SRHMM000189-1 T FAD SRHMM000189-1 A-x-L FAD SRHMM000189-1 Q Substrate H Substrate Y Substrate R Substrate G Substrate SRHMM000189-1 G-G-x(3)-T FAD SRHMM000189-1 T-[TS] FAD SRHMM000189-1 V FAD; via amide nitrogen and carbonyl oxygen 1 PIRSR000190-1 Domain

PIRSF000190 Bacteria

SRHMM000190-1 R-x(2)-Y Substrate binding [KR] Substrate Y Substrate R Substrate S Substrate R-x-[HN] Substrate binding 1 PIRSR000190-2 Domain

PIRSF000190 Bacteria

SRHMM000190-2 FTGRP_1 SRHMM000190-2 FTGRP_2 SRHMM000190-2 FTGRP_3 SRHMM000190-2 FTGRP_4 SRHMM000190-2 FTGRP_5 SRHMM000190-2 FTGRP_6 SRHMM000190-2 FTGRP_7 SRHMM000190-2 FTGRP_8 FMN FMN Binds 1 FMN per subunit. SRHMM000190-2 R-x(4)-K FMN SRHMM000190-2 Q-S FMN SRHMM000190-2 [RK] FMN SRHMM000190-2 [YF]-T FMN SRHMM000190-2 K FMN SRHMM000190-2 Q FMN SRHMM000190-2 W FMN SRHMM000190-2 R FMN 1 PIRSR000192-1 Domain

PIRSF000192 Bacteria

SRHMM000192-1 W Tryptophylquinone 6'-substrate hemiaminal intermediate D Proton acceptor 1 PIRSR000192-2 Domain

PIRSF000192 Bacteria

SRHMM000192-2 D Substrate N Substrate binding [VLI] Substrate binding 1 PIRSR000192-3 Domain

PIRSF000192 Bacteria

SRHMM000192-3 T Transition state stabilizer 1 PIRSR000192-4 Domain

PIRSF000192 Bacteria

SRHMM000192-4 C-x(64)-C C-x(31)-C C-x(82)-C C-x(47)-C C-x(43)-C C-x(30)-C C-x(30)-C 1 PIRSR000192-5 Domain

PIRSF000192 Bacteria

SRHMM000192-5 W-x(50)-W Tryptophan tryptophylquinone (Trp-Trp) 1 PIRSR000192-6 Domain

PIRSF000192 Bacteria

SRHMM000192-6 W Tryptophylquinone 1 PIRSR000194-1 Domain

PIRSF000194 Bacteria

SRHMM000194-1 I Substrate; via carbonyl oxygen A NADP; via amide nitrogen and carbonyl oxygen V-x(5)-A NADP D Substrate H-T NADP R Substrate R Substrate S-S NADP K NADP; via carbonyl oxygen G-x(6)-Q NADP T Substrate 1 PIRSR000196-1 Domain

PIRSF000196 Bacteria

SRHMM000196-1 K Substrate R Substrate R Substrate 1 PIRSR000196-2 Domain

PIRSF000196 Bacteria

SRHMM000196-2 FTGRP_1 SRHMM000196-2 FTGRP_2 SRHMM000196-2 FTGRP_3 SRHMM000196-2 FTGRP_4 SRHMM000196-2 FTGRP_5 FAD Nucleotide-binding FAD Binds 1 FAD per subunit. SRHMM000196-2 K FAD SRHMM000196-2 M FAD SRHMM000196-2 K-x-A FAD SRHMM000196-2 Q FAD SRHMM000196-2 [TS]-H FAD 1 PIRSR000197-1 Domain

PIRSF000197 Bacteria

SRHMM000197-1 E C 1 PIRSR000199-50 Domain

PIRSF000199 Bacteria

SRHMM000199-50 FTGRP_1 NADP SRHMM000199-50 I Substrate; via amide nitrogen SRHMM000199-50 K-x(3)-A NADP V-x-Y NADP 1 PIRSR000207-1 Domain

PIRSF000207 Bacteria

SRHMM000207-1 FTGRP_1 SRHMM000207-1 FTGRP_2 SRHMM000207-1 FTGRP_3 FMN FMN Binds 1 FMN per subunit. SRHMM000207-1 FTGRP_10 SRHMM000207-1 FTGRP_11 SRHMM000207-1 FTGRP_12 NADP SRHMM000207-1 FTGRP_4 SRHMM000207-1 FTGRP_5 SRHMM000207-1 FTGRP_6 SRHMM000207-1 FTGRP_7 SRHMM000207-1 FTGRP_8 SRHMM000207-1 FTGRP_9 SRHMM000207-1 FTGRP_13 FAD FAD Binds 1 FAD per subunit. SRHMM000207-1 S-x-T-x-N-[AG] FMN SRHMM000207-1 [TS]-x-[GAS] FAD SRHMM000207-1 T FAD SRHMM000207-1 S-[RQ] NADP SRHMM000207-1 A FAD; via carbonyl oxygen SRHMM000207-1 R-x-Y-S FAD SRHMM000207-1 K-x(3)-Q NADP SRHMM000207-1 L-x(8)-[CA] FMN SRHMM000207-1 G-x(2)-S FAD SRHMM000207-1 Y FAD SRHMM000207-1 S-T-x-G FMN SRHMM000207-1 D NADP SRHMM000207-1 Y FAD 1 PIRSR000209-1 Domain

PIRSF000209 Eukaryota Bacteria

SRHMM000209-1 FTGRP_1 Heme Iron Metal-binding heme SRHMM000209-1 C Iron (heme axial ligand) 1 PIRSR000216-1 Domain

PIRSF000216 Eukaryota Bacteria

SRHMM000216-1 FTGRP_1 2Fe-2S Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster. SRHMM000216-1 C Iron-sulfur (2Fe-2S) C Iron-sulfur (2Fe-2S) C Iron-sulfur (2Fe-2S) C Iron-sulfur (2Fe-2S) 1 PIRSR000232-1 Domain

PIRSF000232 Bacteria

SRHMM000232-1 FTGRP_1 SRHMM000232-1 FTGRP_2 SRHMM000232-1 FTGRP_3 SRHMM000232-1 FTGRP_4 FMN FMN Binds 1 FMN per subunit. SRHMM000232-1 R FMN; shared with dimeric partner SRHMM000232-1 [HA] FMN; shared with dimeric partner SRHMM000232-1 [WLM]-x-[STLG] FMN SRHMM000232-1 R-x-[ST] FMN 1 PIRSR000233-1 Domain

PIRSF000233 Eukaryota

SRHMM000233-1 FTGRP_1 Metal-binding Molybdenum Mo-molybdopterin Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. SRHMM000233-1 C Molybdenum 1 PIRSR000235-1 Domain

PIRSF000235 Eukaryota Bacteria

SRHMM000235-1 C Thioimidate intermediate 1 PIRSR000235-3 Domain

PIRSF000235 Eukaryota Bacteria

SRHMM000235-3 FTGRP_1 SRHMM000235-3 FTGRP_2 Metal-binding Potassium SRHMM000235-3 G Potassium; via carbonyl oxygen SRHMM000235-3 G Potassium; via carbonyl oxygen 1 PIRSR000238-1 Domain

PIRSF000238 Bacteria

SRHMM000238-1 FTGRP_2 NAD NADP SRHMM000238-1 FTGRP_1 SRHMM000238-1 FTGRP_3 FAD FAD Binds 1 FAD per subunit. SRHMM000238-1 [RDHKE]-x(13)-A NAD or NADP SRHMM000238-1 T-x(9)-D FAD SRHMM000238-1 [DE]-x(14)-[IVL] FAD 1 PIRSR000238-2 Domain

PIRSF000238 Bacteria

SRHMM000238-2 FTGRP_1 Disulfide bond Redox-active center SRHMM000238-2 C-x(2)-C Redox-active 1 PIRSR000239-1 Domain

PIRSF000239 Archaea Eukaryota Bacteria

SRHMM000239-1 C Cysteine sulfenic acid (-SOH) intermediate 1 PIRSR000241-1 Domain

PIRSF000241 Eukaryota Bacteria

SRHMM000241-1 K Charge relay system T Charge relay system H Charge relay system 1 PIRSR000241-2 Domain

PIRSF000241 Eukaryota Bacteria

SRHMM000241-2 T-D Substrate binding F Substrate R Substrate V-Q Substrate binding 1 PIRSR000242-1 Domain

PIRSF000242 Bacteria

SRHMM000242-1 FTGRP_1 SRHMM000242-1 FTGRP_2 SRHMM000242-1 FTGRP_3 SRHMM000242-1 FTGRP_4 SRHMM000242-1 FTGRP_5 SRHMM000242-1 FTGRP_6 SRHMM000242-1 FTGRP_7 SRHMM000242-1 FTGRP_8 SRHMM000242-1 FTGRP_9 SRHMM000242-1 FTGRP_10 SRHMM000242-1 FTGRP_11 SRHMM000242-1 FTGRP_12 SRHMM000242-1 FTGRP_13 SRHMM000242-1 FTGRP_14 SRHMM000242-1 FTGRP_15 SRHMM000242-1 FTGRP_16 SRHMM000242-1 FTGRP_17 Heme heme c Binds 8 heme c groups per subunit. Binds 8 heme groups per subunit. SRHMM000242-1 C Heme 3; covalent SRHMM000242-1 C Heme 8; covalent SRHMM000242-1 C Heme 4; covalent SRHMM000242-1 C Heme 4; covalent SRHMM000242-1 Y Heme 4; covalent SRHMM000242-1 C Heme 8; covalent SRHMM000242-1 C Heme 1; covalent SRHMM000242-1 C Heme 5; covalent SRHMM000242-1 C Heme 2; covalent SRHMM000242-1 C Heme 3; covalent SRHMM000242-1 C Heme 5; covalent SRHMM000242-1 C Heme 6; covalent SRHMM000242-1 C Heme 6; covalent SRHMM000242-1 C Heme 7; covalent SRHMM000242-1 C Heme 7; covalent SRHMM000242-1 C Heme 1; covalent SRHMM000242-1 C Heme 2; covalent 1 PIRSR000242-2 Domain

PIRSF000242 Bacteria

SRHMM000242-2 FTGRP_1 SRHMM000242-2 FTGRP_2 SRHMM000242-2 FTGRP_3 SRHMM000242-2 FTGRP_4 SRHMM000242-2 FTGRP_5 SRHMM000242-2 FTGRP_6 SRHMM000242-2 FTGRP_7 SRHMM000242-2 FTGRP_8 SRHMM000242-2 FTGRP_9 SRHMM000242-2 FTGRP_10 SRHMM000242-2 FTGRP_11 SRHMM000242-2 FTGRP_12 SRHMM000242-2 FTGRP_13 SRHMM000242-2 FTGRP_14 SRHMM000242-2 FTGRP_15 Iron Metal-binding SRHMM000242-2 H Iron (heme 7 axial ligand) SRHMM000242-2 H Iron (heme 3 axial ligand) SRHMM000242-2 H Iron (heme 2 axial ligand) SRHMM000242-2 H Iron (heme 1 axial ligand) SRHMM000242-2 H Iron (heme 5 axial ligand) SRHMM000242-2 H Iron (heme 5 axial ligand) SRHMM000242-2 H Iron (heme 6 axial ligand) SRHMM000242-2 H Iron (heme 4 axial ligand) SRHMM000242-2 H Iron (heme 8 axial ligand) SRHMM000242-2 H Iron (heme 6 axial ligand) SRHMM000242-2 H Iron (heme 2 axial ligand) SRHMM000242-2 H Iron (heme 1 axial ligand) SRHMM000242-2 H Iron (heme 3 axial ligand) SRHMM000242-2 H Iron (heme 8 axial ligand) SRHMM000242-2 H Iron (heme 7 axial ligand) 1 PIRSR000260-1 Domain

PIRSF000260 Eukaryota Bacteria

SRHMM000260-1 C Nucleophile 1 PIRSR000260-2 Domain

PIRSF000260 Eukaryota Bacteria

SRHMM000260-2 FTGRP_1 SRHMM000260-2 FTGRP_2 SRHMM000260-2 FTGRP_3 SRHMM000260-2 FTGRP_4 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. SRHMM000260-2 C Iron-sulfur (4Fe-4S) SRHMM000260-2 C Iron-sulfur (4Fe-4S) SRHMM000260-2 C Iron-sulfur (4Fe-4S) SRHMM000260-2 C Iron-sulfur (4Fe-4S) 1 PIRSR000260-3 Domain

PIRSF000260 Eukaryota Bacteria

SRHMM000260-3 H Increases the nucleophilicity of the active site Cys 1 PIRSR000260-4 Domain

PIRSF000260 Eukaryota Bacteria

SRHMM000260-4 FTGRP_1 Disulfide bond SRHMM000260-4 C-x(29)-C Redox-active 1 PIRSR000262-1 Domain

PIRSF000262 Archaea

SRHMM000262-1 FTGRP_1 Metal-binding Nickel SRHMM000262-1 Q Nickel 1 PIRSR000262-2 Domain

PIRSF000262 Archaea

SRHMM000262-2 FTGRP_1 Metal-binding Nickel SRHMM000262-2 H Pros-methylhistidine R 5-methylarginine 1 PIRSR000278-1 Domain

PIRSF000278 Eukaryota

SRHMM000278-1 FTGRP_1 SRHMM000278-1 FTGRP_2 Disulfide bond SRHMM000278-1 C-x(13)-C SRHMM000278-1 C-x(34)-C 1 PIRSR000290-1 Domain

PIRSF000290 Eukaryota

SRHMM000290-1 FTGRP_1 SRHMM000290-1 FTGRP_2 SRHMM000290-1 FTGRP_3 SRHMM000290-1 FTGRP_4 SRHMM000290-1 FTGRP_5 SRHMM000290-1 FTGRP_6 Copper Metal-binding Cu(2+) Binds 2 copper ions per subunit. SRHMM000290-1 H Copper A SRHMM000290-1 H Copper A SRHMM000290-1 H Copper A SRHMM000290-1 H Copper B SRHMM000290-1 H Copper B SRHMM000290-1 H Copper B 1 PIRSR000290-2 Domain

PIRSF000290 Eukaryota

SRHMM000290-2 FTGRP_1 SRHMM000290-2 FTGRP_2 Disulfide bond SRHMM000290-2 C-x(14)-C SRHMM000290-2 C-x(62)-C 1 PIRSR000290-3 Domain

PIRSF000290 Eukaryota

SRHMM000290-3 C-x(16)-H 2'-(S-cysteinyl)-histidine (Cys-His) 1 PIRSR000294-1 Domain

PIRSF000294 Bacteria

SRHMM000294-1 FTGRP_1 SRHMM000294-1 FTGRP_2 SRHMM000294-1 FTGRP_3 SRHMM000294-1 FTGRP_4 Heme heme Binds 2 heme groups. Binds 2 heme groups per subunit. SRHMM000294-1 C Heme 1; covalent SRHMM000294-1 C Heme 2; covalent SRHMM000294-1 C Heme 2; covalent SRHMM000294-1 C Heme 1; covalent 1 PIRSR000294-2 Domain

PIRSF000294 Bacteria

SRHMM000294-2 FTGRP_1 SRHMM000294-2 FTGRP_2 SRHMM000294-2 FTGRP_3 SRHMM000294-2 FTGRP_4 Iron Metal-binding SRHMM000294-2 H Iron (heme 1 axial ligand) SRHMM000294-2 H Iron (heme 2 axial ligand) SRHMM000294-2 H Iron (heme 1 axial ligand) SRHMM000294-2 M Iron (heme 2 axial ligand) 1 PIRSR000296-1 Domain

PIRSF000296 Bacteria

SRHMM000296-1 H 1 PIRSR000296-2 Domain

PIRSF000296 Bacteria

SRHMM000296-2 FTGRP_1 Heme Iron Metal-binding SRHMM000296-2 Y Iron (heme axial ligand) 1 PIRSR000303-1 Domain

PIRSF000303 Eukaryota Bacteria

SRHMM000303-1 [UC] 1 PIRSR000310-1 Domain

PIRSF000310 Bacteria

SRHMM000310-1 FTGRP_1 3Fe-4S 4Fe-4S Iron Iron-sulfur Metal-binding [3Fe-4S] cluster Binds 1 [3Fe-4S] cluster. [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. SRHMM000310-1 C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) H Iron-sulfur 2 (4Fe-4S); via pros nitrogen C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 3 (3Fe-4S) C Iron-sulfur 3 (3Fe-4S) C Iron-sulfur 3 (3Fe-4S) 1 PIRSR000331-1 Domain

PIRSF000331 Bacteria

SRHMM000331-1 R-x(3)-Y Substrate binding H Substrate S-T Substrate binding 1 PIRSR000331-2 Domain

PIRSF000331 Bacteria

SRHMM000331-2 FTGRP_1 SRHMM000331-2 FTGRP_2 SRHMM000331-2 FTGRP_3 SRHMM000331-2 FTGRP_4 FAD SRHMM000331-2 T FAD SRHMM000331-2 Q-x(2)-R FAD SRHMM000331-2 D-x(2)-R FAD SRHMM000331-2 H-x-[LIVM] FAD 1 PIRSR000333-1 Domain

PIRSF000333 Eukaryota

SRHMM000333-1 FTGRP_1 Heme Iron Metal-binding SRHMM000333-1 C Iron (heme axial ligand) 1 PIRSR000336-1 Domain

PIRSF000336 Eukaryota

SRHMM000336-1 FTGRP_1 SRHMM000336-1 FTGRP_2 SRHMM000336-1 FTGRP_3 Iron Metal-binding Fe(2+) SRHMM000336-1 H Iron SRHMM000336-1 E Iron SRHMM000336-1 H Iron 1 PIRSR000337-1 Domain

PIRSF000337 Bacteria

SRHMM000337-1 FTGRP_1 SRHMM000337-1 FTGRP_2 SRHMM000337-1 FTGRP_3 SRHMM000337-1 FTGRP_4 FMN FMN SRHMM000337-1 H-x(3)-Y FMN binding SRHMM000337-1 T FMN SRHMM000337-1 D FMN; via amide nitrogen and carbonyl oxygen SRHMM000337-1 A-x(2)-S FMN binding 1 PIRSR000343-1 Domain

PIRSF000343 Eukaryota Bacteria

SRHMM000343-1 FTGRP_1 SRHMM000343-1 FTGRP_2 SRHMM000343-1 FTGRP_3 Heme SRHMM000343-1 Y Heme SRHMM000343-1 [KR] Heme SRHMM000343-1 R Heme 1 PIRSR000343-2 Domain

PIRSF000343 Viruses Eukaryota Bacteria

SRHMM000343-2 FTGRP_1 Iron Metal-binding SRHMM000343-2 H Iron (heme axial ligand) 1 PIRSR000346-1 Domain

PIRSF000346 Eukaryota Bacteria

SRHMM000346-1 FTGRP_1 SRHMM000346-1 FTGRP_2 SRHMM000346-1 FTGRP_3 SRHMM000346-1 FTGRP_4 SRHMM000346-1 FTGRP_5 SRHMM000346-1 FTGRP_6 SRHMM000346-1 FTGRP_7 SRHMM000346-1 FTGRP_8 Iron Metal-binding Fe cation Binds 2 iron ions per subunit. SRHMM000346-1 E Iron 2 SRHMM000346-1 E Iron 1 SRHMM000346-1 E Iron 2 SRHMM000346-1 E Iron 2 SRHMM000346-1 H Iron 1; via pros nitrogen SRHMM000346-1 E Iron 1 SRHMM000346-1 E Iron 1 SRHMM000346-1 H Iron 2; via pros nitrogen 1 PIRSR000349-1 Domain

PIRSF000349 Eukaryota Bacteria Archaea Viruses

SRHMM000349-1 FTGRP_1 SRHMM000349-1 FTGRP_2 SRHMM000349-1 FTGRP_3 SRHMM000349-1 FTGRP_4 Metal-binding SRHMM000349-1 H Divalent metal cation SRHMM000349-1 H Divalent metal cation SRHMM000349-1 D Divalent metal cation SRHMM000349-1 H Divalent metal cation 1 PIRSR000350-2 Domain

PIRSF000350 Eukaryota Bacteria

SRHMM000350-2 H Proton acceptor 1 PIRSR000350-3 Domain

PIRSF000350 Eukaryota Bacteria

SRHMM000350-3 FTGRP_4 SRHMM000350-3 FTGRP_5 SRHMM000350-3 FTGRP_6 NAD SRHMM000350-3 FTGRP_1 SRHMM000350-3 FTGRP_2 SRHMM000350-3 FTGRP_3 SRHMM000350-3 FTGRP_7 SRHMM000350-3 FTGRP_8 FAD FAD Binds 1 FAD per subunit. SRHMM000350-3 FTGRP_1 SRHMM000350-3 FTGRP_2 SRHMM000350-3 FTGRP_3 SRHMM000350-3 FTGRP_4 SRHMM000350-3 FTGRP_5 SRHMM000350-3 FTGRP_6 SRHMM000350-3 FTGRP_7 SRHMM000350-3 FTGRP_8 Nucleotide-binding SRHMM000350-3 E NAD SRHMM000350-3 G-x(6)-E NAD SRHMM000350-3 M-x(2)-H FAD SRHMM000350-3 D FAD SRHMM000350-3 T-x-S FAD SRHMM000350-3 G NAD; via amide nitrogen SRHMM000350-3 G FAD; via amide nitrogen and carbonyl oxygen SRHMM000350-3 K FAD 1 PIRSR000350-4 Domain

PIRSF000350 Eukaryota Bacteria

SRHMM000350-4 C-x(4)-C Redox-active 1 PIRSR000354-1 Domain

PIRSF000354 Eukaryota

SRHMM000354-1 FTGRP_1 SRHMM000354-1 FTGRP_2 SRHMM000354-1 FTGRP_3 SRHMM000354-1 FTGRP_4 SRHMM000354-1 FTGRP_5 SRHMM000354-1 FTGRP_6 SRHMM000354-1 FTGRP_7 Disulfide bond SRHMM000354-1 C-x(25)-C SRHMM000354-1 C-x(3)-C SRHMM000354-1 C-x(80)-C SRHMM000354-1 C-x(147)-C SRHMM000354-1 C-x(25)-C SRHMM000354-1 C-x(80)-C SRHMM000354-1 C-x(25)-C 1 PIRSR000355-1 Domain

PIRSF000355 Eukaryota Bacteria Archaea Viruses

SRHMM000355-1 Y 1 PIRSR000355-2 Domain

PIRSF000355 Eukaryota Bacteria Archaea Viruses

SRHMM000355-2 FTGRP_1 SRHMM000355-2 FTGRP_2 SRHMM000355-2 FTGRP_3 SRHMM000355-2 FTGRP_4 SRHMM000355-2 FTGRP_5 Iron Metal-binding Fe cation Binds 2 iron ions per subunit. SRHMM000355-2 [DE] Iron 1 E Iron 2 SRHMM000355-2 E Iron 2 SRHMM000355-2 E Iron 1 E Iron 2 SRHMM000355-2 H Iron 2 SRHMM000355-2 H Iron 1 1 PIRSR000361-1 Domain

PIRSF000361 Eukaryota Bacteria

SRHMM000361-1 FTGRP_1 SRHMM000361-1 FTGRP_2 SRHMM000361-1 FTGRP_3 SRHMM000361-1 FTGRP_4 SRHMM000361-1 FTGRP_5 SRHMM000361-1 FTGRP_6 SRHMM000361-1 FTGRP_7 SRHMM000361-1 FTGRP_8 NADP SRHMM000361-1 K NADP SRHMM000361-1 E NADP SRHMM000361-1 S-[RK] NADP SRHMM000361-1 T NADP; via amide nitrogen SRHMM000361-1 [KR] NADP SRHMM000361-1 V-P NADP SRHMM000361-1 G-L NADP SRHMM000361-1 S NADP 1 PIRSR000362-1 Domain

PIRSF000362 Eukaryota Bacteria

SRHMM000362-1 FTGRP_1 SRHMM000362-1 FTGRP_2 SRHMM000362-1 FTGRP_3 SRHMM000362-1 FTGRP_4 SRHMM000362-1 FTGRP_5 SRHMM000362-1 FTGRP_6 FAD FAD SRHMM000362-1 G-x-I FAD SRHMM000362-1 W FAD; via amide nitrogen SRHMM000362-1 [SA] FAD; via amide nitrogen SRHMM000362-1 L FAD; via amide nitrogen SRHMM000362-1 [VIL] FAD; via amide nitrogen and carbonyl oxygen SRHMM000362-1 E FAD 1 PIRSR000362-2 Domain

PIRSF000362 Eukaryota Bacteria

SRHMM000362-2 FTGRP_1 SRHMM000362-2 FTGRP_2 SRHMM000362-2 FTGRP_3 SRHMM000362-2 FTGRP_4 NADP SRHMM000362-2 E NADP SRHMM000362-2 [NQH]-x-N-V NADP SRHMM000362-2 G NADP; via amide nitrogen SRHMM000362-2 R-R NADP 1 PIRSR000376-1 Domain

PIRSF000376 Bacteria Archaea

SRHMM000376-1 T 5-methoxybenzimidazolylcob(I)amide SRHMM000376-1 [AS] 5-methoxybenzimidazolylcob(I)amide; via amide nitrogen SRHMM000376-1 T 5-methoxybenzimidazolylcob(I)amide SRHMM000376-1 G-x(2)-V 5-methoxybenzimidazolylcob(I)amide binding 1 PIRSR000376-2 Domain

PIRSF000376 Archaea Bacteria

SRHMM000376-2 FTGRP_1 SRHMM000376-2 FTGRP_2 SRHMM000376-2 FTGRP_3 SRHMM000376-2 FTGRP_4 4Fe-4S Iron Iron-sulfur Metal-binding SRHMM000376-2 C Iron-sulfur (4Fe-4S) SRHMM000376-2 C Iron-sulfur (4Fe-4S) SRHMM000376-2 C Iron-sulfur (4Fe-4S) SRHMM000376-2 C Iron-sulfur (4Fe-4S) 1 PIRSR000381-1 Domain

PIRSF000381 Archaea Eukaryota Bacteria

SRHMM000381-1 FTGRP_4 Cobalt Metal-binding SRHMM000381-1 FTGRP_1 SRHMM000381-1 FTGRP_2 SRHMM000381-1 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM000381-1 C Zinc SRHMM000381-1 C Zinc SRHMM000381-1 C Zinc SRHMM000381-1 H Cobalt (cobalamin axial ligand) 1 PIRSR000381-2 Domain

PIRSF000381 Eukaryota Bacteria

SRHMM000381-2 FTGRP_3 SRHMM000381-2 FTGRP_4 SRHMM000381-2 FTGRP_6 S-adenosyl-L-methionine SRHMM000381-2 FTGRP_1 SRHMM000381-2 FTGRP_2 SRHMM000381-2 FTGRP_5 Cobalamin methylcob(III)alamin SRHMM000381-2 Y-[YF] S-adenosyl-L-methionine binding SRHMM000381-2 G-A Cobalamin-binding SRHMM000381-2 D S-adenosyl-L-methionine SRHMM000381-2 S Cobalamin SRHMM000381-2 R S-adenosyl-L-methionine; via carbonyl oxygen SRHMM000381-2 G Cobalamin; via carbonyl oxygen 1 PIRSR000384-1 Domain

PIRSF000384 Eukaryota

SRHMM000384-1 FTGRP_1 SRHMM000384-1 FTGRP_2 SRHMM000384-1 FTGRP_3 SRHMM000384-1 FTGRP_4 SRHMM000384-1 FTGRP_5 SRHMM000384-1 FTGRP_6 SRHMM000384-1 FTGRP_7 S-adenosyl-L-methionine SRHMM000384-1 N S-adenosyl-L-methionine SRHMM000384-1 Y S-adenosyl-L-methionine SRHMM000384-1 D-[VA] S-adenosyl-L-methionine binding SRHMM000384-1 Y S-adenosyl-L-methionine SRHMM000384-1 G-[SA] S-adenosyl-L-methionine binding SRHMM000384-1 Y S-adenosyl-L-methionine SRHMM000384-1 D S-adenosyl-L-methionine 1 PIRSR000385-1 Domain

PIRSF000385 Eukaryota Bacteria

SRHMM000385-1 Y Substrate N Substrate R Substrate Y Substrate 1 PIRSR000385-2 Domain

PIRSF000385 Eukaryota Bacteria

SRHMM000385-2 FTGRP_1 SRHMM000385-2 FTGRP_2 SRHMM000385-2 FTGRP_3 SRHMM000385-2 FTGRP_4 SRHMM000385-2 FTGRP_5 SRHMM000385-2 FTGRP_6 SRHMM000385-2 FTGRP_7 S-adenosyl-L-methionine SRHMM000385-2 [ND]-W S-adenosyl-L-methionine binding SRHMM000385-2 A S-adenosyl-L-methionine; via carbonyl oxygen SRHMM000385-2 D S-adenosyl-L-methionine SRHMM000385-2 [LQ] S-adenosyl-L-methionine; via carbonyl oxygen SRHMM000385-2 Y S-adenosyl-L-methionine SRHMM000385-2 W S-adenosyl-L-methionine SRHMM000385-2 R S-adenosyl-L-methionine 1 PIRSR000386-1 Domain

PIRSF000386 Bacteria

SRHMM000386-1 FTGRP_1 SRHMM000386-1 FTGRP_2 S-adenosyl-L-methionine SRHMM000386-1 G S-adenosyl-L-methionine; via amide nitrogen SRHMM000386-1 [ILMV]-G-[DEN]-[YF]-[VI]-[LIVM] S-adenosyl-L-methionine binding 1 PIRSR000388-1 Domain

PIRSF000388 Archaea Bacteria

SRHMM000388-1 [ED] Proton acceptor 1 PIRSR000388-2 Domain

PIRSF000388 Archaea Bacteria

SRHMM000388-2 D-[ST] Alpha-ketoisovalerate binding D Alpha-ketoisovalerate [KR] Alpha-ketoisovalerate 1 PIRSR000388-3 Domain

PIRSF000388 Archaea Bacteria

SRHMM000388-3 FTGRP_1 SRHMM000388-3 FTGRP_2 SRHMM000388-3 FTGRP_3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM000388-3 D Magnesium SRHMM000388-3 D Magnesium SRHMM000388-3 E Magnesium 1 PIRSR000389-1 Domain

PIRSF000389 Eukaryota

SRHMM000389-1 C 1 PIRSR000390-1 Domain

PIRSF000390 Bacteria

SRHMM000390-1 K Proton acceptor 1 PIRSR000390-2 Domain

PIRSF000390 Bacteria

SRHMM000390-2 FTGRP_1 Pyridoxal phosphate SRHMM000390-2 K N6-(pyridoxal phosphate)lysine 1 PIRSR000398-1 Domain

PIRSF000398 Bacteria

SRHMM000398-1 W S-adenosyl-L-methionine K S-adenosyl-L-methionine; via amide nitrogen D S-adenosyl-L-methionine D S-adenosyl-L-methionine 1 PIRSR000409-1 Domain

PIRSF000409 Bacteria

SRHMM000409-1 C Nucleophile; methyl group acceptor from phosphotriester C Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine 1 PIRSR000409-2 Domain

PIRSF000409 Bacteria

SRHMM000409-2 FTGRP_1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM000409-2 T DNA R DNA [RK] DNA R DNA 1 PIRSR000409-3 Domain

PIRSF000409 Bacteria

SRHMM000409-3 FTGRP_1 SRHMM000409-3 FTGRP_2 SRHMM000409-3 FTGRP_3 SRHMM000409-3 FTGRP_4 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM000409-3 C Zinc SRHMM000409-3 C Zinc SRHMM000409-3 C Zinc SRHMM000409-3 C Zinc 1 PIRSR000410-1 Domain

PIRSF000410 Proteobacteria

SRHMM000410-1 FTGRP_1 SRHMM000410-1 FTGRP_2 SRHMM000410-1 FTGRP_3 SRHMM000410-1 FTGRP_4 SRHMM000410-1 FTGRP_5 SRHMM000410-1 FTGRP_6 SRHMM000410-1 FTGRP_7 S-adenosyl-L-methionine SRHMM000410-1 R S-adenosyl-L-methionine SRHMM000410-1 [DE] S-adenosyl-L-methionine SRHMM000410-1 R-N S-adenosyl-L-methionine binding SRHMM000410-1 [ED] S-adenosyl-L-methionine SRHMM000410-1 [ND]-[LM] S-adenosyl-L-methionine binding SRHMM000410-1 N S-adenosyl-L-methionine SRHMM000410-1 [TS] S-adenosyl-L-methionine 1 PIRSR000412-50 Domain This rule was created based on analysis for RESID:AA0119.

PIRSF000412 Viruses Archaea Eukaryota Bacteria

SRHMM000412-50 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM000412-50 K N6-(pyridoxal phosphate)lysine 1 PIRSR000429-1 Domain

PIRSF000429 Eukaryota Bacteria

SRHMM000429-1 C Acyl-thioester intermediate H Proton acceptor C Proton acceptor 1 PIRSR000429-2 Domain

PIRSF000429 Eukaryota Bacteria

SRHMM000429-2 Y Coenzyme A R-x-D Coenzyme A binding K Coenzyme A S Coenzyme A 1 PIRSR000431-2 Domain

PIRSF000431 Eukaryota

SRHMM000431-2 H-x(4)-D HXXXXD motif 1 PIRSR000439-1 Domain

PIRSF000439 Eukaryota

SRHMM000439-1 H 1 PIRSR000440-1 Domain

PIRSF000440 Bacteria

SRHMM000440-1 H Proton acceptor 1 PIRSR000443-1 Domain

PIRSF000443 Archaea Eukaryota Bacteria

SRHMM000443-1 S Nucleophile D H 1 PIRSR000445-1 Domain

PIRSF000445 Archaea Eukaryota Bacteria

SRHMM000445-1 C Nucleophile 1 PIRSR000445-2 Domain

PIRSF000445 Archaea Eukaryota Bacteria

SRHMM000445-2 T-C-x-R Substrate binding S Substrate [ED]-x-[EDQH] Substrate binding Q Substrate 1 PIRSR000445-3 Domain

PIRSF000445 Archaea Eukaryota Bacteria

SRHMM000445-3 FTGRP_1 NADP SRHMM000445-3 [GA]-x-[GQ]-x(2)-[GCSAINV] NADP 1 PIRSR000445-4 Domain

PIRSF000445 Archaea Eukaryota Bacteria

SRHMM000445-4 H Important for activity 1 PIRSR000446-1 Domain

PIRSF000446 Bacteria

SRHMM000446-1 S H 1 PIRSR000447-1 Domain

PIRSF000447 Eukaryota Bacteria

SRHMM000447-1 C 1 PIRSR000450-1 Domain

PIRSF000450 Bacteria

SRHMM000450-1 C Acyl-thioester intermediate 1 PIRSR000451-1 Domain

PIRSF000451 Embryophyta Bacteria

SRHMM000451-1 C 1 PIRSR000452-1 Domain

PIRSF000452 Bacteria

SRHMM000452-1 W Substrate H Substrate Y Substrate E Substrate [ILV]-x-[VI] Acetyl-CoA binding [QR]-x(4)-[KR] Acetyl-CoA binding D Substrate N Acetyl-CoA [ED] Substrate 1 PIRSR000454-1 Domain

PIRSF000454 Fungi

SRHMM000454-1 C For beta-ketoacyl synthase activity 1 PIRSR000454-2 Domain

PIRSF000454 Fungi

SRHMM000454-2 D-x-E Acetyl-CoA binding Y Acetyl-CoA S Acetyl-CoA E-x(11)-G-x(3)-[ASPE] Acetyl-CoA binding [RVNSE]-x(2)-[KNSG] Acetyl-CoA binding I-x-H Acetyl-CoA binding 1 PIRSR000454-3 Domain

PIRSF000454 Fungi

SRHMM000454-3 FTGRP_1 SRHMM000454-3 FTGRP_2 SRHMM000454-3 FTGRP_3 SRHMM000454-3 FTGRP_4 SRHMM000454-3 FTGRP_5 Magnesium Metal-binding SRHMM000454-3 D Magnesium SRHMM000454-3 S Magnesium SRHMM000454-3 V Magnesium; via carbonyl oxygen SRHMM000454-3 E Magnesium SRHMM000454-3 H Magnesium; via carbonyl oxygen 1 PIRSR000454-4 Domain

PIRSF000454 Fungi

SRHMM000454-4 FTGRP_1 Phosphopantetheine SRHMM000454-4 S O-(pantetheine 4'-phosphoryl)serine 1 PIRSR000459-1 Domain

PIRSF000459 Eukaryota

SRHMM000459-1 C H D 1 PIRSR000459-2 Domain

PIRSF000459 Eukaryota

SRHMM000459-2 FTGRP_1 Metal-binding Calcium Ca(2+) Binds 1 Ca(2+) ion per subunit. SRHMM000459-2 N Calcium D Calcium E Calcium E Calcium 1 PIRSR000460-1 Domain

PIRSF000460 Archaea Eukaryota Bacteria

SRHMM000460-1 FTGRP_1 Pyridoxal phosphate SRHMM000460-1 K N6-(pyridoxal phosphate)lysine 1 PIRSR000463-1 Domain

PIRSF000463 Eukaryota Bacteria

SRHMM000463-1 D Nucleophile E Proton donor 1 PIRSR000472-50 Domain

PIRSF000472 Metazoa

SRHMM000472-50 R-R Important for donor substrate binding 1 PIRSR000472-51 Domain

PIRSF000472 Metazoa

SRHMM000472-51 P-x(5)-P SH3-binding 1 PIRSR000472-52 Domain

PIRSF000472 Metazoa

SRHMM000472-52 FTGRP_1 Disulfide bond SRHMM000472-52 C-x(61)-C C-x(17)-C C-x(3)-C C-x(6)-C 1 PIRSR000477-2 Domain

PIRSF000477 Eukaryota Bacteria

SRHMM000477-2 S Phosphate H Phosphate R-x-H Phosphate binding [AG] Phosphate; via amide nitrogen E Purine nucleoside S Phosphate N Purine nucleoside 1 PIRSR000485-1 Domain

PIRSF000485 Eukaryota Bacteria Archaea

SRHMM000485-1 C Nucleophile 1 PIRSR000485-2 Domain

PIRSF000485 Archaea Eukaryota Bacteria

SRHMM000485-2 FTGRP_1 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM000485-2 [ST] Magnesium D Magnesium D Magnesium 1 PIRSR000485-3 Domain

PIRSF000485 Archaea Eukaryota Bacteria

SRHMM000485-3 FTGRP_1 Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster per subunit. SRHMM000485-3 C Iron-sulfur (4Fe-4S) C Iron-sulfur (4Fe-4S) C Iron-sulfur (4Fe-4S) C Iron-sulfur (4Fe-4S) 1 PIRSR000495-1 Domain

PIRSF000495 Archaea Eukaryota Bacteria

SRHMM000495-1 C Nucleophile H E 1 PIRSR000498-1 Domain

PIRSF000498 Bacteria

SRHMM000498-1 G-x-[IV] Lumazine 1 binding C-x-T Lumazine 2 binding; shared with one trimeric partner [ED]-x-W Lumazine 2 binding; shared with one trimeric partner G-x-[VI] Lumazine 2 binding; shared with one trimeric partner K Lumazine 2 S-x-T Lumazine 1 binding [LHNS]-x(4)-[ST] Lumazine 1 binding 1 PIRSR000509-1 Domain

PIRSF000509 Eukaryota

SRHMM000509-1 Q Substrate SRHMM000509-1 K Substrate SRHMM000509-1 Y Substrate SRHMM000509-1 Y Substrate SRHMM000509-1 Y Substrate SRHMM000509-1 E L-tryptophan SRHMM000509-1 Y Substrate SRHMM000509-1 R L-tryptophan SRHMM000509-1 Y Substrate SRHMM000509-1 R Substrate SRHMM000509-1 Y L-tryptophan SRHMM000509-1 K Substrate SRHMM000509-1 R Substrate SRHMM000509-1 [IV]-[LVM] L-tryptophan binding 1 PIRSR000517-1 Domain

PIRSF000517 Eukaryota

SRHMM000517-1 FTGRP_1 pyridoxal 5'-phosphate SRHMM000517-1 K N6-(pyridoxal phosphate)lysine 1 PIRSR000524-50 Domain This rule was created based on analysis for RESID:AA0119.

PIRSF000524 Eukaryota Bacteria

SRHMM000524-50 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM000524-50 K N6-(pyridoxal phosphate)lysine 1 PIRSR000548-1 Domain

PIRSF000548 Eukaryota

SRHMM000548-1 FTGRP_1 SRHMM000548-1 FTGRP_2 SRHMM000548-1 FTGRP_3 SRHMM000548-1 FTGRP_4 cAMP cAMP-binding Nucleotide-binding SRHMM000548-1 R cAMP 1 SRHMM000548-1 E cAMP 2 SRHMM000548-1 R cAMP 2 SRHMM000548-1 E cAMP 1 1 PIRSR000550-1 Domain

PIRSF000550 Eukaryota

SRHMM000550-1 D Proton acceptor 1 PIRSR000550-2 Domain

PIRSF000550 Eukaryota

SRHMM000550-2 Y Phosphatidylinositol 4,5-bisphosphate SRHMM000550-2 W Phosphatidylinositol 4,5-bisphosphate 1 PIRSR000550-3 Domain

PIRSF000550 Eukaryota

SRHMM000550-3 FTGRP_1 SRHMM000550-3 FTGRP_2 ATP-binding SRHMM000550-3 [LI]-x(2)-G-x(2)-G-x-V ATP SRHMM000550-3 K ATP 1 PIRSR000551-50 Domain

PIRSF000551 Eukaryota

SRHMM000551-50 D Proton acceptor 1 PIRSR000551-51 Domain

PIRSF000551 Eukaryota

SRHMM000551-51 FTGRP_1 SRHMM000551-51 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000551-51 K ATP SRHMM000551-51 L-x(7)-V ATP 1 PIRSR000552-1 Domain

PIRSF000552 Eukaryota

SRHMM000552-1 D Proton acceptor 1 PIRSR000552-2 Domain

PIRSF000552 Eukaryota

SRHMM000552-2 FTGRP_1 SRHMM000552-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000552-2 K ATP SRHMM000552-2 L-G-x-G-x(2)-G-x-V ATP 1 PIRSR000554-1 Domain

PIRSF000554 Eukaryota

SRHMM000554-1 D Proton acceptor 1 PIRSR000554-2 Domain

PIRSF000554 Eukaryota

SRHMM000554-2 FTGRP_1 SRHMM000554-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000554-2 K ATP SRHMM000554-2 I-G-x-G-x(4)-V ATP 1 PIRSR000556-1 Domain

PIRSF000556 Eukaryota

SRHMM000556-1 D Proton acceptor 1 PIRSR000556-2 Domain

PIRSF000556 Eukaryota

SRHMM000556-2 FTGRP_1 SRHMM000556-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000556-2 K ATP SRHMM000556-2 I-G-x-G-x(2)-G-x-V ATP 1 PIRSR000559-1 Domain

PIRSF000559 Eukaryota

SRHMM000559-1 D Proton acceptor 1 PIRSR000559-2 Domain

PIRSF000559 Eukaryota

SRHMM000559-2 FTGRP_1 SRHMM000559-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000559-2 K ATP SRHMM000559-2 L-G-x-G-x(2)-G-x-V ATP 1 PIRSR000604-1 Domain

PIRSF000604 Eukaryota

SRHMM000604-1 D Proton acceptor 1 PIRSR000604-2 Domain

PIRSF000604 Eukaryota

SRHMM000604-2 FTGRP_1 SRHMM000604-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000604-2 K ATP SRHMM000604-2 L-G-x(6)-V ATP 1 PIRSR000605-50 Domain

PIRSF000605 Eukaryota

SRHMM000605-50 D Proton acceptor 1 PIRSR000605-51 Domain

PIRSF000605 Eukaryota

SRHMM000605-51 FTGRP_1 SRHMM000605-51 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000605-51 L-x(7)-V ATP SRHMM000605-51 K ATP 1 PIRSR000606-50 Domain

PIRSF000606 Eukaryota

SRHMM000606-50 D Proton acceptor D Proton acceptor 1 PIRSR000606-51 Domain

PIRSF000606 Eukaryota

SRHMM000606-51 FTGRP_1 SRHMM000606-51 FTGRP_2 SRHMM000606-51 FTGRP_3 SRHMM000606-51 FTGRP_4 ATP-binding Nucleotide-binding SRHMM000606-51 L-x(7)-V ATP SRHMM000606-51 [LI]-x(7)-[CV] ATP SRHMM000606-51 K ATP SRHMM000606-51 K ATP 1 PIRSR000617-1 Domain

PIRSF000617 Eukaryota

SRHMM000617-1 D Proton acceptor 1 PIRSR000617-2 Domain

PIRSF000617 Eukaryota

SRHMM000617-2 FTGRP_1 SRHMM000617-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000617-2 I-x(7)-V ATP SRHMM000617-2 K ATP 1 PIRSR000617-4 Domain

PIRSF000617 Eukaryota Viruses

SRHMM000617-4 Y Phosphotyrosine; by autocatalysis Y Phosphotyrosine; by autocatalysis Y Phosphotyrosine; by autocatalysis Y Phosphotyrosine; by autocatalysis 1 PIRSR000619-1 Domain

PIRSF000619 Eukaryota

SRHMM000619-1 D Proton acceptor 1 PIRSR000619-2 Domain

PIRSF000619 Eukaryota

SRHMM000619-2 FTGRP_1 SRHMM000619-2 FTGRP_2 ATP-binding SRHMM000619-2 L-x(7)-V ATP SRHMM000619-2 K ATP 1 PIRSR000620-1 Domain

PIRSF000620 Eukaryota

SRHMM000620-1 D Proton acceptor 1 PIRSR000620-2 Domain

PIRSF000620 Eukaryota

SRHMM000620-2 FTGRP_1 SRHMM000620-2 FTGRP_2 SRHMM000620-2 FTGRP_3 SRHMM000620-2 FTGRP_4 SRHMM000620-2 FTGRP_5 ATP-binding Nucleotide-binding SRHMM000620-2 D ATP SRHMM000620-2 S ATP SRHMM000620-2 K ATP SRHMM000620-2 R-N ATP SRHMM000620-2 E-x(5)-D ATP 1 PIRSR000624-1 Domain

PIRSF000624 Eukaryota

SRHMM000624-1 D Proton acceptor 1 PIRSR000624-2 Domain

PIRSF000624 Eukaryota

SRHMM000624-2 FTGRP_1 SRHMM000624-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000624-2 K ATP SRHMM000624-2 L-G-x(4)-G-x-[VI] ATP 1 PIRSR000628-1 Domain

PIRSF000628 Eukaryota

SRHMM000628-1 D Proton acceptor 1 PIRSR000631-1 Domain

PIRSF000631 Eukaryota

SRHMM000631-1 D Proton acceptor 1 PIRSR000631-3 Domain

PIRSF000631 Eukaryota

SRHMM000631-3 C-x(4)-C 1 PIRSR000631-4 Domain

PIRSF000631 Eukaryota

SRHMM000631-4 N-x-[ST] N-linked (GlcNAc...) asparagine 1 PIRSR000632-1 Domain

PIRSF000632 Eukaryota

SRHMM000632-1 D Proton acceptor 1 PIRSR000632-2 Domain

PIRSF000632 Eukaryota

SRHMM000632-2 FTGRP_1 SRHMM000632-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000632-2 [IL]-G-x-G-x(2)-G-x-V ATP SRHMM000632-2 K ATP 1 PIRSR000636-1 Domain

PIRSF000636 Eukaryota

SRHMM000636-1 D Proton acceptor 1 PIRSR000636-2 Domain

PIRSF000636 Eukaryota

SRHMM000636-2 FTGRP_1 SRHMM000636-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000636-2 [LI]-x(2)-G-x(2)-G-x-V ATP SRHMM000636-2 K ATP 1 PIRSR000660-1 Domain

PIRSF000660 Eukaryota

SRHMM000660-1 D Proton acceptor 1 PIRSR000660-2 Domain

PIRSF000660 Eukaryota

SRHMM000660-2 FTGRP_1 SRHMM000660-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000660-2 K ATP SRHMM000660-2 [LIM]-G-x-G-x(2)-G-x-V ATP 1 PIRSR000661-50 Domain

PIRSF000661 Saccharomycetes

SRHMM000661-50 D Proton acceptor 1 PIRSR000661-51 Domain

PIRSF000661 Saccharomycetes

SRHMM000661-51 FTGRP_1 ATP-binding Nucleotide-binding SRHMM000661-51 [VIL]-x(7)-V ATP K ATP 1 PIRSR000666-1 Domain

PIRSF000666 Eukaryota

SRHMM000666-1 D Proton acceptor 1 PIRSR000666-2 Domain

PIRSF000666 Eukaryota

SRHMM000666-2 FTGRP_1 SRHMM000666-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM000666-2 [IVL]-G-x-G-x(2)-G-x-[VLI] ATP SRHMM000666-2 K ATP 1 PIRSR000699-1 Domain

PIRSF000699 Bacteria

SRHMM000699-1 H Tele-phosphohistidine intermediate 1 PIRSR000699-2 Domain

PIRSF000699 Bacteria

SRHMM000699-2 FTGRP_1 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per trimer. SRHMM000699-2 D Magnesium; shared with all trimeric partners 1 PIRSR000705-1 Domain

PIRSF000705 Viruses Eukaryota Bacteria

SRHMM000705-1 [ED] Proton acceptor 1 PIRSR000705-2 Domain

PIRSF000705 Viruses Eukaryota Bacteria

SRHMM000705-2 E Substrate Y Substrate Q Substrate R Substrate D Substrate E Substrate 1 PIRSR000705-3 Domain

PIRSF000705 Viruses Eukaryota Bacteria

SRHMM000705-3 FTGRP_1 SRHMM000705-3 FTGRP_2 SRHMM000705-3 FTGRP_3 ATP-binding Nucleotide-binding SRHMM000705-3 G-x(7)-[TSD] ATP SRHMM000705-3 [ELD]-x-F ATP SRHMM000705-3 R-x(3)-R ATP 1 PIRSR000706-1 Domain

PIRSF000706 Bacteria

SRHMM000706-1 D Proton acceptor 1 PIRSR000706-2 Domain

PIRSF000706 Bacteria

SRHMM000706-2 FTGRP_1 SRHMM000706-2 FTGRP_2 Metal-binding Magnesium SRHMM000706-2 D Magnesium SRHMM000706-2 N Magnesium 1 PIRSR000724-1 Domain

PIRSF000724 Archaea Eukaryota Bacteria

SRHMM000724-1 D-x-N Substrate binding R Substrate H-x(2)-[RK] Substrate binding R Substrate R Substrate 1 PIRSR000724-2 Domain

PIRSF000724 Archaea Eukaryota Bacteria

SRHMM000724-2 FTGRP_1 SRHMM000724-2 FTGRP_2 SRHMM000724-2 FTGRP_3 SRHMM000724-2 FTGRP_4 ATP-binding SRHMM000724-2 G-x-D-[TS] ATP SRHMM000724-2 K ATP SRHMM000724-2 G ATP; via carbonyl oxygen SRHMM000724-2 E ATP 1 PIRSR000726-1 Domain

PIRSF000726 Bacteria

SRHMM000726-1 FTGRP_1 SRHMM000726-1 FTGRP_3 SRHMM000726-1 FTGRP_4 SRHMM000726-1 FTGRP_5 SRHMM000726-1 FTGRP_6 ATP-binding Nucleotide-binding SRHMM000726-1 T Substrate E Substrate SRHMM000726-1 T-D ATP SRHMM000726-1 K-x(2)-G ATP SRHMM000726-1 Y ATP; via amide nitrogen and carbonyl oxygen SRHMM000726-1 K-V ATP SRHMM000726-1 R ATP 1 PIRSR000732-1 Domain

PIRSF000732 Bacteria Archaea

SRHMM000732-1 H Tele-phosphohistidine intermediate C Proton donor 1 PIRSR000732-2 Domain

PIRSF000732 Bacteria Archaea

SRHMM000732-2 R PEP R PEP N-D PEP binding R PEP 1 PIRSR000732-3 Domain

PIRSF000732 Bacteria Archaea

SRHMM000732-3 FTGRP_1 SRHMM000732-3 FTGRP_2 Magnesium Metal-binding Mg(2+) SRHMM000732-3 D Magnesium SRHMM000732-3 E Magnesium 1 PIRSR000806-1 Domain

PIRSF000806 Eukaryota Bacteria

SRHMM000806-1 H Substrate 1 PIRSR000806-2 Domain

PIRSF000806 Eukaryota Bacteria

SRHMM000806-2 K UTP Q UTP G UTP; via amide nitrogen D UTP K UTP 1 PIRSR000808-1 Domain

PIRSF000808 Archaea Eukaryota Bacteria

SRHMM000808-1 H Tele-UMP-histidine intermediate 1 PIRSR000808-2 Domain

PIRSF000808 Eukaryota Bacteria Archaea

SRHMM000808-2 R-x(2)-R UDP-alpha-D-glucose binding; shared with dimeric partner [VA] UDP-alpha-D-glucose; via amide nitrogen N-[DG] UDP-alpha-D-glucose binding N UDP-alpha-D-glucose G-x-S UDP-alpha-D-glucose binding Q UDP-alpha-D-glucose K-F UDP-alpha-D-glucose binding; shared with dimeric partner [YF]-E UDP-alpha-D-glucose binding; shared with dimeric partner Q UDP-alpha-D-glucose 1 PIRSR000808-3 Domain

PIRSF000808 Archaea Eukaryota Bacteria

SRHMM000808-3 FTGRP_1 Zinc Metal-binding Zn(2+) Binds 1 zinc ion per subunit. SRHMM000808-3 C Zinc C Zinc H Zinc H Zinc 1 PIRSR000808-4 Domain

PIRSF000808 Archaea Eukaryota Bacteria

SRHMM000808-4 FTGRP_1 Iron Metal-binding Fe cation Binds 1 Fe cation per subunit. SRHMM000808-4 E Iron H Iron H Iron H Iron 1 PIRSR000817-1 Domain

PIRSF000817 Eukaryota

SRHMM000817-1 FTGRP_1 SRHMM000817-1 FTGRP_2 SRHMM000817-1 FTGRP_3 Magnesium Metal-binding Mg(2+) SRHMM000817-1 D Magnesium SRHMM000817-1 D Magnesium SRHMM000817-1 D Magnesium 1 PIRSR000846-1 Domain

PIRSF000846 Eukaryota Bacteria

SRHMM000846-1 H Nucleophile 1 PIRSR000846-2 Domain

PIRSF000846 Eukaryota Bacteria

SRHMM000846-2 K Substrate N-K Substrate binding N Substrate G-x(2)-Q Substrate binding Q Substrate N-x-T Substrate binding [ML] Substrate; via carbonyl oxygen K Substrate 1 PIRSR000853-1 Domain

PIRSF000853 Eukaryota Bacteria

SRHMM000853-1 H Tele-phosphohistidine intermediate C Proton donor 1 PIRSR000853-2 Domain

PIRSF000853 Eukaryota Bacteria

SRHMM000853-2 R Substrate R Substrate E Substrate G Substrate; via carbonyl oxygen T Substrate; via amide nitrogen N Substrate D Substrate; via amide nitrogen 1 PIRSR000853-3 Domain

PIRSF000853 Eukaryota Bacteria Archaea

SRHMM000853-3 FTGRP_1 SRHMM000853-3 FTGRP_2 Magnesium Metal-binding Mg(2+) SRHMM000853-3 D Magnesium SRHMM000853-3 E Magnesium 1 PIRSR000858-1 Domain

PIRSF000858 Eukaryota Bacteria

SRHMM000858-1 E 5-glutamyl coenzyme A thioester intermediate 1 PIRSR000862-1 Domain

PIRSF000862 Eukaryota

SRHMM000862-1 S Nucleophile D Charge relay system H Charge relay system 1 PIRSR000865-1 Domain

PIRSF000865 Eukaryota

SRHMM000865-1 S Nucleophile D Charge relay system H Charge relay system 1 PIRSR000865-2 Domain

PIRSF000865 Eukaryota

SRHMM000865-2 FTGRP_1 SRHMM000865-2 FTGRP_2 SRHMM000865-2 FTGRP_3 SRHMM000865-2 FTGRP_4 Calcium Metal-binding SRHMM000865-2 D Calcium SRHMM000865-2 E Calcium; via carbonyl oxygen SRHMM000865-2 D Calcium SRHMM000865-2 R Calcium; via carbonyl oxygen 1 PIRSR000865-3 Domain

PIRSF000865 Eukaryota

SRHMM000865-3 FTGRP_1 Disulfide bond SRHMM000865-3 C-x(5)-C C-x(10)-C C-x(23)-C C-x(10)-C C-x(4)-C C-x(15)-C 1 PIRSR000882-1 Domain

PIRSF000882 Eukaryota

SRHMM000882-1 H Proton donor 1 PIRSR000894-1 Domain

PIRSF000894 Eukaryota

SRHMM000894-1 H Nucleophile D Proton donor 1 PIRSR000894-2 Domain

PIRSF000894 Eukaryota

SRHMM000894-2 FTGRP_1 SRHMM000894-2 FTGRP_2 SRHMM000894-2 FTGRP_3 SRHMM000894-2 FTGRP_4 SRHMM000894-2 FTGRP_5 Disulfide bond SRHMM000894-2 C-x(17)-C SRHMM000894-2 C-x(249)-C SRHMM000894-2 C-x(342)-C SRHMM000894-2 C-x(7)-C SRHMM000894-2 C-x(8)-C 1 PIRSR000898-1 Domain

PIRSF000898 Eukaryota Bacteria

SRHMM000898-1 FTGRP_1 SRHMM000898-1 FTGRP_2 SRHMM000898-1 FTGRP_3 SRHMM000898-1 FTGRP_4 SRHMM000898-1 FTGRP_5 SRHMM000898-1 FTGRP_6 SRHMM000898-1 FTGRP_7 SRHMM000898-1 FTGRP_8 Iron Metal-binding Fe cation Binds 2 iron ions per subunit. SRHMM000898-1 Y Iron 1 SRHMM000898-1 D Iron 1 SRHMM000898-1 N Iron 2 SRHMM000898-1 H Iron 2 SRHMM000898-1 H Iron 2 SRHMM000898-1 H Iron 1 SRHMM000898-1 D Iron 1 SRHMM000898-1 D Iron 2 1 PIRSR000898-2 Domain

PIRSF000898 Eukaryota Bacteria

SRHMM000898-2 FTGRP_1 Disulfide bond SRHMM000898-2 C-x(57)-C 1 PIRSR000898-3 Domain

PIRSF000898 Eukaryota

SRHMM000898-3 N-x-[ST] N-linked (GlcNAc...) asparagine 1 PIRSR000905-1 Domain

PIRSF000905 Eukaryota

SRHMM000905-1 H Proton donor H Nucleophile 1 PIRSR000905-2 Domain

PIRSF000905 Eukaryota

SRHMM000905-2 R Substrate R Substrate 1 PIRSR000915-1 Domain

PIRSF000915 Eukaryota Bacteria

SRHMM000915-1 D Nucleophile [DN] Proton donor 1 PIRSR000915-2 Domain

PIRSF000915 Eukaryota Bacteria

SRHMM000915-2 [ST]-x(3)-R Substrate binding H Substrate K Substrate 1 PIRSR000926-1 Domain

PIRSF000926 Eukaryota

SRHMM000926-1 C Phosphocysteine intermediate 1 PIRSR000926-2 Domain

PIRSF000926 Eukaryota

SRHMM000926-2 D Substrate C-x(5)-R Substrate binding Q Substrate 1 PIRSR000927-1 Domain

PIRSF000927 Eukaryota

SRHMM000927-1 C Phosphocysteine intermediate 1 PIRSR000927-2 Domain

PIRSF000927 Eukaryota

SRHMM000927-2 D Substrate C-x(5)-R Substrate binding Q Substrate 1 PIRSR000929-1 Domain

PIRSF000929 Eukaryota

SRHMM000929-1 C Phosphocysteine intermediate 1 PIRSR000929-2 Domain

PIRSF000929 Eukaryota

SRHMM000929-2 D Substrate Q Substrate 1 PIRSR000933-50 Domain This rule was created based on analysis for RESID:AA0034.

PIRSF000933 Eukaryota

SRHMM000933-50 C Phosphocysteine intermediate 1 PIRSR000933-51 Domain This rule was created based on analysis for RESID:AA0034.

PIRSF000933 Eukaryota

SRHMM000933-51 D Substrate C-x(5)-R Substrate binding Q Substrate 1 PIRSR000934-1 Domain

PIRSF000934 Eukaryota

SRHMM000934-1 C Phosphocysteine intermediate 1 PIRSR000939-1 Domain

PIRSF000939 Eukaryota

SRHMM000939-1 C Phosphocysteine intermediate 1 PIRSR000941-50 Domain

PIRSF000941 Eukaryota

SRHMM000941-50 C Phosphocysteine intermediate 1 PIRSR000948-1 Domain

PIRSF000948 Eukaryota

SRHMM000948-1 FTGRP_1 SRHMM000948-1 FTGRP_2 SRHMM000948-1 FTGRP_3 SRHMM000948-1 FTGRP_4 SRHMM000948-1 FTGRP_5 SRHMM000948-1 FTGRP_6 SRHMM000948-1 FTGRP_7 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. SRHMM000948-1 H Zinc 2; via tele nitrogen SRHMM000948-1 H Zinc 2; via pros nitrogen SRHMM000948-1 N Zinc 2 SRHMM000948-1 D Zinc 1 D Zinc 2 SRHMM000948-1 H Zinc 1; via tele nitrogen SRHMM000948-1 D Zinc 1 SRHMM000948-1 H Zinc 1; via tele nitrogen 1 PIRSR000948-2 Domain

PIRSF000948 Eukaryota

SRHMM000948-2 FTGRP_1 SRHMM000948-2 FTGRP_2 SRHMM000948-2 FTGRP_3 SRHMM000948-2 FTGRP_4 SRHMM000948-2 FTGRP_5 SRHMM000948-2 FTGRP_6 SRHMM000948-2 FTGRP_7 SRHMM000948-2 FTGRP_8 Disulfide bond SRHMM000948-2 C-x(45)-C SRHMM000948-2 C-x(12)-C SRHMM000948-2 C-x(3)-C SRHMM000948-2 C-x(64)-C SRHMM000948-2 C-x(4)-C SRHMM000948-2 C-x(22)-C SRHMM000948-2 C-x(75)-C SRHMM000948-2 C-x(10)-C 1 PIRSR000952-1 Domain

PIRSF000952 Eukaryota

SRHMM000952-1 S Phosphoserine S Phosphoserine 1 PIRSR000956-1 Domain

PIRSF000956 Eukaryota

SRHMM000956-1 H H 1 PIRSR000970-1 Domain

PIRSF000970 Eukaryota

SRHMM000970-1 H Proton acceptor H Proton donor 1 PIRSR000970-2 Domain

PIRSF000970 Eukaryota

SRHMM000970-2 T Substrate T Substrate 1 PIRSR000972-50 Domain This rule was created based on analysis for RESID:AA0185.

PIRSF000972 Chlamydomonadales Fungi

SRHMM000972-50 FTGRP_1 The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. SRHMM000972-50 C 3-oxoalanine (Cys) 1 PIRSR000977-1 Domain

PIRSF000977 Bacteria

SRHMM000977-1 E Substrate [RK] Substrate 1 PIRSR000977-2 Domain

PIRSF000977 Bacteria

SRHMM000977-2 FTGRP_1 SRHMM000977-2 FTGRP_2 SRHMM000977-2 FTGRP_3 Magnesium Metal-binding Mg(2+) Binds 2 Mg(2+) ions per monomer. SRHMM000977-2 D Magnesium 2 SRHMM000977-2 E Magnesium 2 SRHMM000977-2 D Magnesium 1 1 PIRSR000977-3 Domain

PIRSF000977 Bacteria

SRHMM000977-3 R Important for interaction with ssb H Important for activity Y Important for interaction with ssb Q Important for interaction with ssb R Important for interaction with ssb 1 PIRSR000988-1 Domain

PIRSF000988 Eukaryota

SRHMM000988-1 E H 1 PIRSR000988-2 Domain

PIRSF000988 Eukaryota

SRHMM000988-2 FTGRP_1 SRHMM000988-2 FTGRP_2 Disulfide bond SRHMM000988-2 C-x(35)-C Essential for enzymatic activity SRHMM000988-2 C-x(2)-C 1 PIRSR000988-3 Domain

PIRSF000988 Archaea Eukaryota Bacteria

SRHMM000988-3 FTGRP_1 Disulfide bond SRHMM000988-3 C-x(35)-C Essential for enzymatic activity 1 PIRSR001000-1 Domain

PIRSF001000 Viruses Bacteria

SRHMM001000-1 E Proton acceptor 1 PIRSR001013-1 Domain

PIRSF001013 Bacteria

SRHMM001013-1 E Proton acceptor H Proton donor 1 PIRSR001021-1 Domain

PIRSF001021 Bacteria

SRHMM001021-1 D Nucleophile E Proton donor 1 PIRSR001021-2 Domain

PIRSF001021 Bacteria

SRHMM001021-2 FTGRP_1 SRHMM001021-2 FTGRP_2 SRHMM001021-2 FTGRP_3 SRHMM001021-2 FTGRP_4 SRHMM001021-2 FTGRP_5 SRHMM001021-2 FTGRP_6 SRHMM001021-2 FTGRP_7 SRHMM001021-2 FTGRP_8 SRHMM001021-2 FTGRP_9 SRHMM001021-2 FTGRP_10 SRHMM001021-2 FTGRP_11 Calcium Metal-binding SRHMM001021-2 D Calcium 3 SRHMM001021-2 D Calcium 2 SRHMM001021-2 A Calcium 2; via carbonyl oxygen SRHMM001021-2 [ND] Calcium 1 SRHMM001021-2 H Calcium 1; via carbonyl oxygen SRHMM001021-2 G Calcium 3; via carbonyl oxygen SRHMM001021-2 D Calcium 2 SRHMM001021-2 D Calcium 3 SRHMM001021-2 D Calcium 2 SRHMM001021-2 D Calcium 1 SRHMM001021-2 D Calcium 1 1 PIRSR001024-1 Domain

PIRSF001024 Eukaryota

SRHMM001024-1 D Nucleophile E Proton donor 1 PIRSR001024-2 Domain

PIRSF001024 Eukaryota

SRHMM001024-2 D Transition state stabilizer 1 PIRSR001024-3 Domain

PIRSF001024 Eukaryota

SRHMM001024-3 FTGRP_1 Calcium Metal-binding SRHMM001024-3 [ND] Calcium 1 E Calcium 1; via carbonyl oxygen D Calcium 1 D Calcium 2 H Calcium 1; via carbonyl oxygen E Calcium 2 1 PIRSR001024-4 Domain

PIRSF001024 Eukaryota

SRHMM001024-4 FTGRP_1 SRHMM001024-4 FTGRP_2 SRHMM001024-4 FTGRP_3 SRHMM001024-4 FTGRP_4 Disulfide bond SRHMM001024-4 C-x(42)-C SRHMM001024-4 C-x(34)-C SRHMM001024-4 C-x(13)-C SRHMM001024-4 C-x(7)-C 1 PIRSR001024-5 Domain

PIRSF001024 Eukaryota

SRHMM001024-5 Q Substrate SRHMM001024-5 G Substrate; via amide nitrogen SRHMM001024-5 D Substrate SRHMM001024-5 H Substrate SRHMM001024-5 R Substrate SRHMM001024-5 R Substrate SRHMM001024-5 W Substrate 1 PIRSR001028-1 Domain

PIRSF001028 Viridiplantae

SRHMM001028-1 D Nucleophile E Proton donor 1 PIRSR001028-2 Domain

PIRSF001028 Viridiplantae

SRHMM001028-2 H-x-V Substrate binding Y-[ML] Substrate binding R-x(4)-[RK] Substrate binding W Substrate [NS] Substrate Q Substrate [DE] Substrate K Substrate G-x-[WYL] Substrate binding H Substrate Q Substrate K Substrate [YI]-x-V Substrate binding T-x(5)-D Substrate binding W Substrate 1 PIRSR001031-1 Domain

PIRSF001031 Eukaryota

SRHMM001031-1 D Proton acceptor E Proton donor 1 PIRSR001031-2 Domain

PIRSF001031 Eukaryota

SRHMM001031-2 W Substrate 1 PIRSR001060-1 Domain

PIRSF001060 Eukaryota Bacteria

SRHMM001060-1 E Proton donor 1 PIRSR001060-2 Domain

PIRSF001060 Eukaryota Bacteria

SRHMM001060-2 FTGRP_1 SRHMM001060-2 FTGRP_2 SRHMM001060-2 FTGRP_3 SRHMM001060-2 FTGRP_4 SRHMM001060-2 FTGRP_5 SRHMM001060-2 FTGRP_6 SRHMM001060-2 FTGRP_7 Disulfide bond SRHMM001060-2 C-x(3)-C SRHMM001060-2 C-x(7)-C SRHMM001060-2 C-x(14)-C SRHMM001060-2 C-x(11)-C SRHMM001060-2 C-x(61)-C SRHMM001060-2 C-x(13)-C SRHMM001060-2 C-x(31)-C 1 PIRSR001065-1 Domain

PIRSF001065 Eukaryota

SRHMM001065-1 E D 1 PIRSR001072-1 Domain

PIRSF001072 Viruses

SRHMM001072-1 N-x-[ST] N-linked (GlcNAc...) asparagine; by host SRHMM001072-1 N-x-[TS] N-linked (GlcNAc...) asparagine; by host SRHMM001072-1 N-x-[TS] N-linked (GlcNAc...) asparagine; by host 1 PIRSR001084-1 Domain

PIRSF001084 Bacteria

SRHMM001084-1 E Nucleophile SRHMM001084-1 E Proton donor 1 PIRSR001084-2 Domain

PIRSF001084 Bacteria

SRHMM001084-2 R Substrate SRHMM001084-2 N Substrate SRHMM001084-2 W Substrate 1 PIRSR001084-3 Domain

PIRSF001084 Bacteria

SRHMM001084-3 FTGRP_1 SRHMM001084-3 FTGRP_2 SRHMM001084-3 FTGRP_3 SRHMM001084-3 FTGRP_4 Metal-binding Zinc SRHMM001084-3 C Zinc SRHMM001084-3 C Zinc SRHMM001084-3 C Zinc SRHMM001084-3 C Zinc 1 PIRSR001092-1 Domain

PIRSF001092 Eukaryota Bacteria

SRHMM001092-1 C May be important for catalysis 1 PIRSR001093-1 Domain

PIRSF001093 Eukaryota

SRHMM001093-1 E Proton donor 1 PIRSR001093-2 Domain

PIRSF001093 Eukaryota

SRHMM001093-2 FTGRP_1 Disulfide bond SRHMM001093-2 C-x(45)-C C-x(50)-C C-x(16)-C 1 PIRSR001097-50 Domain

PIRSF001097 Bacteria

SRHMM001097-50 E Nucleophile E Proton donor 1 PIRSR001100-1 Domain

PIRSF001100 Eukaryota Bacteria

SRHMM001100-1 D Proton donor SRHMM001100-1 D Proton acceptor 1 PIRSR001103-1 Domain

PIRSF001103 Bacteria

SRHMM001103-1 E Proton donor 1 PIRSR001109-1 Domain

PIRSF001109 Archaea Eukaryota Bacteria

SRHMM001109-1 T Substrate D Substrate E Substrate K Substrate D Substrate 1 PIRSR001111-50 Domain This rule was created based on analysis for RESID:AA0150.

PIRSF001111 Bacteria Archaea

SRHMM001111-50 FTGRP_1 Phosphopantetheine Phosphoprotein pantetheine 4'-phosphate Binds 1 phosphopantetheine covalently. SRHMM001111-50 S O-(pantetheine 4'-phosphoryl)serine 1 PIRSR001112-1 Domain

PIRSF001112 Eukaryota Bacteria

SRHMM001112-1 D Nucleophile Y Proton donor H Proton acceptor 1 PIRSR001123-1 Domain

PIRSF001123 Bacteria Archaea

SRHMM001123-1 E Proton acceptor 1 PIRSR001123-2 Domain

PIRSF001123 Bacteria Archaea

SRHMM001123-2 FTGRP_1 SRHMM001123-2 FTGRP_2 SRHMM001123-2 FTGRP_3 SRHMM001123-2 FTGRP_4 SRHMM001123-2 FTGRP_5 Metal-binding a divalent metal cation Binds 2 divalent metal cations per subunit. SRHMM001123-2 D Divalent metal cation 1 D Divalent metal cation 2 SRHMM001123-2 H Divalent metal cation 2 SRHMM001123-2 [DE] Divalent metal cation 1 SRHMM001123-2 E Divalent metal cation 2 SRHMM001123-2 H Divalent metal cation 1 1 PIRSR001134-1 Domain

PIRSF001134 Eukaryota Bacteria

SRHMM001134-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001134-2 Domain

PIRSF001134 Eukaryota Bacteria

SRHMM001134-2 FTGRP_1 SRHMM001134-2 FTGRP_2 SRHMM001134-2 FTGRP_3 Disulfide bond SRHMM001134-2 C-x(9)-C SRHMM001134-2 C-x(32)-C SRHMM001134-2 C-x(19)-C 1 PIRSR001137-50 Domain

PIRSF001137 Mammalia

SRHMM001137-50 FTGRP_1 Disulfide bond SRHMM001137-50 C Interchain C-x(33)-C C-x(116)-C Interchain (between alpha and beta chains) C-x(30)-C C-x(29)-C 1 PIRSR001138-1 Domain

PIRSF001138 Eukaryota

SRHMM001138-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001141-1 Domain

PIRSF001141 Eukaryota

SRHMM001141-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001141-2 Domain

PIRSF001141 Eukaryota

SRHMM001141-2 C-x(129)-C Interchain (between light and heavy chains) C-x(133)-C Interchain (between light and heavy chains) C-x(15)-C C-x(68)-C C-x(15)-C C-x(29)-C 1 PIRSR001143-1 Domain

PIRSF001143 Eukaryota

SRHMM001143-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001145-1 Domain

PIRSF001145 Eukaryota

SRHMM001145-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001145-2 Domain

PIRSF001145 Eukaryota

SRHMM001145-2 R-x(9)-Q Important for binding to annexin A2 Y Important for binding to LRP1 K Important for single-chain activity D Important for single-chain activity 1 PIRSR001145-3 Domain

PIRSF001145 Eukaryota

SRHMM001145-3 FTGRP_1 SRHMM001145-3 FTGRP_2 SRHMM001145-3 FTGRP_3 SRHMM001145-3 FTGRP_4 SRHMM001145-3 FTGRP_5 SRHMM001145-3 FTGRP_6 SRHMM001145-3 FTGRP_7 SRHMM001145-3 FTGRP_8 SRHMM001145-3 FTGRP_9 SRHMM001145-3 FTGRP_10 SRHMM001145-3 FTGRP_11 SRHMM001145-3 FTGRP_12 SRHMM001145-3 FTGRP_13 SRHMM001145-3 FTGRP_14 SRHMM001145-3 FTGRP_15 SRHMM001145-3 FTGRP_16 SRHMM001145-3 FTGRP_17 Disulfide bond SRHMM001145-3 C-x(130)-C Interchain (between A and B chains) SRHMM001145-3 C-x(8)-C SRHMM001145-3 C-x(27)-C SRHMM001145-3 C-x(15)-C SRHMM001145-3 C-x(80)-C SRHMM001145-3 C-x(23)-C SRHMM001145-3 C-x(68)-C SRHMM001145-3 C-x(8)-C SRHMM001145-3 C-x(41)-C SRHMM001145-3 C-x(23)-C SRHMM001145-3 C-x(16)-C SRHMM001145-3 C-x(29)-C SRHMM001145-3 C-x(10)-C SRHMM001145-3 C-x(74)-C SRHMM001145-3 C-x(80)-C SRHMM001145-3 C-x(41)-C SRHMM001145-3 C-x(15)-C 1 PIRSR001146-1 Domain

PIRSF001146 Eukaryota

SRHMM001146-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001149-1 Domain

PIRSF001149 Eukaryota

SRHMM001149-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001149-2 Domain

PIRSF001149 Eukaryota

SRHMM001149-2 R-S Cleavage; by thrombin [RK]-T Cleavage; by factor Xa R-[IV] Cleavage; by factor Xa 1 PIRSR001149-3 Domain

PIRSF001149 Eukaryota

SRHMM001149-3 N-x-[TS] N-linked (GlcNAc...) (complex) asparagine N-x-T N-linked (GlcNAc...) (complex) asparagine N-x-T N-linked (GlcNAc...) (complex) asparagine 1 PIRSR001149-4 Domain

PIRSF001149 Eukaryota

SRHMM001149-4 FTGRP_1 SRHMM001149-4 FTGRP_2 SRHMM001149-4 FTGRP_3 SRHMM001149-4 FTGRP_4 SRHMM001149-4 FTGRP_5 SRHMM001149-4 FTGRP_6 SRHMM001149-4 FTGRP_7 SRHMM001149-4 FTGRP_8 SRHMM001149-4 FTGRP_9 SRHMM001149-4 FTGRP_10 SRHMM001149-4 FTGRP_11 SRHMM001149-4 FTGRP_12 Disulfide bond SRHMM001149-4 C-x(4)-C SRHMM001149-4 C-x(15)-C SRHMM001149-4 C-x(13)-C SRHMM001149-4 C-x(12)-C SRHMM001149-4 C-x(39)-C SRHMM001149-4 C-x(77)-C SRHMM001149-4 C-x(145)-C Interchain (between light and heavy chains) SRHMM001149-4 C-x(77)-C SRHMM001149-4 C-x(39)-C SRHMM001149-4 C-x(23)-C SRHMM001149-4 C-x(29)-C SRHMM001149-4 C-x(23)-C 1 PIRSR001150-1 Domain

PIRSF001150 Eukaryota

SRHMM001150-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001150-2 Domain

PIRSF001150 Eukaryota

SRHMM001150-2 R L-lysine SRHMM001150-2 D L-lysine SRHMM001150-2 D L-lysine SRHMM001150-2 R L-lysine SRHMM001150-2 R L-lysine 1 PIRSR001154-1 Domain

PIRSF001154 Eukaryota

SRHMM001154-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001174-1 Domain

PIRSF001174 Eukaryota Bacteria Archaea

SRHMM001174-1 S K 1 PIRSR001174-2 Domain

PIRSF001174 Eukaryota Bacteria Archaea

SRHMM001174-2 FTGRP_1 ATP-binding Nucleotide-binding SRHMM001174-2 G-x(6)-[TS] ATP 1 PIRSR001191-1 Domain

PIRSF001191 Viruses Eukaryota

SRHMM001191-1 E 1 PIRSR001196-1 Domain

PIRSF001196 Eukaryota

SRHMM001196-1 E 1 PIRSR001196-2 Domain

PIRSF001196 Eukaryota

SRHMM001196-2 FTGRP_1 SRHMM001196-2 FTGRP_2 SRHMM001196-2 FTGRP_3 SRHMM001196-2 FTGRP_4 Metal-binding Zinc SRHMM001196-2 H Zinc; via tele nitrogen; catalytic SRHMM001196-2 H Zinc; via tele nitrogen; catalytic SRHMM001196-2 D Zinc; catalytic SRHMM001196-2 H Zinc; via tele nitrogen; catalytic 1 PIRSR001199-1 Domain

PIRSF001199 Eukaryota

SRHMM001199-1 E 1 PIRSR001199-2 Domain

PIRSF001199 Eukaryota

SRHMM001199-2 FTGRP_1 SRHMM001199-2 FTGRP_2 SRHMM001199-2 FTGRP_3 Metal-binding Zinc Zn(2+) SRHMM001199-2 H Zinc; via tele nitrogen; catalytic SRHMM001199-2 H Zinc; via tele nitrogen; catalytic SRHMM001199-2 H Zinc; via tele nitrogen; catalytic 1 PIRSR001205-1 Domain

PIRSF001205 Bacteria

SRHMM001205-1 E 1 PIRSR001205-2 Domain

PIRSF001205 Bacteria

SRHMM001205-2 FTGRP_1 SRHMM001205-2 FTGRP_2 SRHMM001205-2 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM001205-2 H Zinc; via tele nitrogen; catalytic SRHMM001205-2 H Zinc; via tele nitrogen; catalytic SRHMM001205-2 H Zinc; via tele nitrogen; catalytic 1 PIRSR001217-1 Domain

PIRSF001217 Eukaryota Bacteria

SRHMM001217-1 K Proton acceptor S Nucleophile 1 PIRSR001218-1 Domain

PIRSF001218 Viruses

SRHMM001218-1 H [ED] C 1 PIRSR001220-1 Domain

PIRSF001220 Eukaryota Bacteria

SRHMM001220-1 T O-isoaspartyl threonine intermediate 1 PIRSR001220-2 Domain

PIRSF001220 Eukaryota Bacteria

SRHMM001220-2 S Substrate T-D Substrate binding 1 PIRSR001222-50 Domain This rule was created based on analysis for RESID:AA0114.

PIRSF001222 Eukaryota

SRHMM001222-50 FTGRP_1 Carbamylation allows a single lysine to coordinate two nickel ions. SRHMM001222-50 K N6-carboxylysine 1 PIRSR001222-51 Domain This rule was created based on analysis for RESID:AA0114.

PIRSF001222 Eukaryota

SRHMM001222-51 FTGRP_1 Metal-binding Nickel Ni cation Binds 2 nickel ions per subunit. SRHMM001222-51 H Nickel 1; via tele nitrogen H Nickel 1; via tele nitrogen K Nickel 1; via carbamate group K Nickel 2; via carbamate group H Nickel 2; via pros nitrogen H Nickel 2; via tele nitrogen D Nickel 1 1 PIRSR001227-1 Domain

PIRSF001227 Bacteria

SRHMM001227-1 S Nucleophile 1 PIRSR001227-2 Domain

PIRSF001227 Bacteria

SRHMM001227-2 FTGRP_1 SRHMM001227-2 FTGRP_2 SRHMM001227-2 FTGRP_3 SRHMM001227-2 FTGRP_4 SRHMM001227-2 FTGRP_5 SRHMM001227-2 FTGRP_6 Calcium Metal-binding Ca(2+) Binds 1 Ca(2+) ion per dimer. SRHMM001227-2 P Calcium; via carbonyl oxygen SRHMM001227-2 D Calcium SRHMM001227-2 E Calcium SRHMM001227-2 D Calcium SRHMM001227-2 D Calcium SRHMM001227-2 V Calcium; via carbonyl oxygen 1 PIRSR001235-1 Domain

PIRSF001235 Bacteria

SRHMM001235-1 FTGRP_1 SRHMM001235-1 FTGRP_2 SRHMM001235-1 FTGRP_3 SRHMM001235-1 FTGRP_4 SRHMM001235-1 FTGRP_5 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. SRHMM001235-1 H Zinc 1; via tele nitrogen SRHMM001235-1 D Zinc 1 D Zinc 2 SRHMM001235-1 H Zinc 2; via tele nitrogen SRHMM001235-1 E Zinc 2 SRHMM001235-1 H Zinc 1; via tele nitrogen 1 PIRSR001235-2 Domain

PIRSF001235 Bacteria

SRHMM001235-2 FTGRP_1 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. SRHMM001235-2 R Allantoate N Allantoate; via carbonyl oxygen R Allantoate 1 PIRSR001238-1 Domain

PIRSF001238 Bacteria

SRHMM001238-1 D Proton acceptor 1 PIRSR001238-2 Domain

PIRSF001238 Bacteria

SRHMM001238-2 G-x-E Substrate binding T Substrate Y Substrate R Substrate R Substrate S Substrate; via amide nitrogen and carbonyl oxygen 1 PIRSR001238-3 Domain

PIRSF001238 Bacteria

SRHMM001238-3 FTGRP_1 SRHMM001238-3 FTGRP_2 SRHMM001238-3 FTGRP_3 SRHMM001238-3 FTGRP_4 SRHMM001238-3 FTGRP_5 SRHMM001238-3 FTGRP_6 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. SRHMM001238-3 D Zinc 1; catalytic SRHMM001238-3 H Zinc 1; via tele nitrogen; catalytic SRHMM001238-3 H Zinc 1; via tele nitrogen; catalytic SRHMM001238-3 K Zinc 1; via carbamate group; catalytic K Zinc 2; via carbamate group; catalytic SRHMM001238-3 H Zinc 2; via pros nitrogen; catalytic SRHMM001238-3 H Zinc 2; via tele nitrogen; catalytic 1 PIRSR001238-50 Domain This rule was created based on analysis for RESID:AA0114.

PIRSF001238 Bacteria

SRHMM001238-50 FTGRP_1 Carbamylation allows a single lysine to coordinate two zinc ions. SRHMM001238-50 K N6-carboxylysine 1 PIRSR001247-1 Domain

PIRSF001247 Eukaryota

SRHMM001247-1 D H D C 1 PIRSR001336-50 Domain This rule was created based on analysis for RESID:AA0119.

PIRSF001336 Eukaryota Bacteria

SRHMM001336-50 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM001336-50 K N6-(pyridoxal phosphate)lysine 1 PIRSR001338-1 Domain

PIRSF001338 Archaea Bacteria

SRHMM001338-1 S Substrate D Substrate [RK] Substrate 1 PIRSR001341-1 Domain

PIRSF001341 Bacteria

SRHMM001341-1 E Proton donor 1 PIRSR001341-2 Domain

PIRSF001341 Bacteria

SRHMM001341-2 D Substrate S Substrate 1 PIRSR001341-3 Domain

PIRSF001341 Bacteria

SRHMM001341-3 S-S Cleavage (non-hydrolytic) 1 PIRSR001341-4 Domain

PIRSF001341 Bacteria

SRHMM001341-4 S Pyruvic acid (Ser) 1 PIRSR001341-5 Domain

PIRSF001341 Bacteria

SRHMM001341-5 S Histidine decarboxylase alpha chain SRHMM001341-5 S Histidine decarboxylase beta chain 1 PIRSR001355-1 Domain

PIRSF001355 Bacteria Eukaryota

SRHMM001355-1 S Schiff-base intermediate with substrate; via pyruvic acid C Proton donor; for catalytic activity S Proton acceptor; for processing activity H Proton acceptor; for processing activity 1 PIRSR001355-2 Domain

PIRSF001355 Eukaryota

SRHMM001355-2 F Substrate E Substrate F Substrate E Substrate 1 PIRSR001355-3 Domain

PIRSF001355 Eukaryota

SRHMM001355-3 S Pyruvic acid (Ser); by autocatalysis 1 PIRSR001355-4 Domain

PIRSF001355 Eukaryota

SRHMM001355-4 FTGRP_1 Autocatalytic cleavage SRHMM001355-4 E-S Cleavage (non-hydrolytic); by autolysis 1 PIRSR001355-5 Domain

PIRSF001355 Eukaryota

SRHMM001355-5 FTGRP_1 Autocatalytic cleavage SRHMM001355-5 E S-adenosylmethionine decarboxylase beta chain SRHMM001355-5 S S-adenosylmethionine decarboxylase alpha chain 1 PIRSR001357-50 Domain

PIRSF001357 Eukaryota

SRHMM001357-50 FTGRP_1 Schiff base SRHMM001357-50 K Schiff-base intermediate with acetaldehyde K 1 PIRSR001359-1 Domain

PIRSF001359 Ascomycota Bacteria

SRHMM001359-1 D Proton donor 1 PIRSR001359-2 Domain

PIRSF001359 Ascomycota Bacteria

SRHMM001359-2 G Dihydroxyacetone phosphate; via amide nitrogen G-x-[ST] Dihydroxyacetone phosphate binding N-x(2)-T Dihydroxyacetone phosphate binding 1 PIRSR001359-3 Domain

PIRSF001359 Ascomycota Bacteria

SRHMM001359-3 FTGRP_1 SRHMM001359-3 FTGRP_2 SRHMM001359-3 FTGRP_3 SRHMM001359-3 FTGRP_4 SRHMM001359-3 FTGRP_5 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. SRHMM001359-3 E Zinc 2 SRHMM001359-3 H Zinc 1; catalytic SRHMM001359-3 D Zinc 2 SRHMM001359-3 H Zinc 1; catalytic SRHMM001359-3 H Zinc 1; catalytic 1 PIRSR001362-1 Domain

PIRSF001362 Eukaryota Bacteria Archaea

SRHMM001362-1 C Proton acceptor 1 PIRSR001362-2 Domain

PIRSF001362 Eukaryota Bacteria Archaea

SRHMM001362-2 [SG]-x-W Substrate binding G-H Substrate binding R Substrate N-x(3)-S Substrate binding [TS] Substrate 1 PIRSR001362-3 Domain

PIRSF001362 Eukaryota Bacteria Archaea

SRHMM001362-3 FTGRP_1 Magnesium Metal-binding Mg(2+) Can also use Mn(2+) ion. SRHMM001362-3 D Magnesium 1 PIRSR001363-1 Domain

PIRSF001363 Eukaryota Bacteria

SRHMM001363-1 R Proton acceptor D Proton donor 1 PIRSR001369-1 Domain

PIRSF001369 Archaea Eukaryota Bacteria

SRHMM001369-1 H [DE] 1 PIRSR001373-1 Domain

PIRSF001373 Bacteria

SRHMM001373-1 [ST] Tryptophan Y Substrate R Substrate G Substrate; via amide nitrogen 1 PIRSR001373-2 Domain

PIRSF001373 Bacteria

SRHMM001373-2 FTGRP_1 SRHMM001373-2 FTGRP_2 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM001373-2 E Magnesium SRHMM001373-2 E Magnesium 1 PIRSR001373-3 Domain

PIRSF001373 Bacteria

SRHMM001373-3 P-x-M Tryptophan binding G-T Chorismate binding G-x-G Chorismate binding 1 PIRSR001399-1 Domain

PIRSF001399 Dikarya Bacteria

SRHMM001399-1 Y Proton acceptor H Proton donor 1 PIRSR001399-2 Domain

PIRSF001399 Dikarya Bacteria

SRHMM001399-2 N Substrate H Substrate D Substrate [ILMV]-[ST] Substrate binding R Substrate 1 PIRSR001399-3 Domain

PIRSF001399 Dikarya Bacteria

SRHMM001399-3 R Transition state stabilizer 1 PIRSR001400-1 Domain

PIRSF001400 Archaea Eukaryota Bacteria

SRHMM001400-1 [ED] Proton donor K Proton acceptor 1 PIRSR001400-2 Domain

PIRSF001400 Archaea Eukaryota Bacteria

SRHMM001400-2 H Substrate E Substrate E Substrate D Substrate S-x(2)-S Substrate binding K Substrate 1 PIRSR001415-1 Domain

PIRSF001415 Archaea Eukaryota Bacteria

SRHMM001415-1 K Schiff-base intermediate with substrate K Schiff-base intermediate with substrate 1 PIRSR001415-2 Domain

PIRSF001415 Archaea Eukaryota Bacteria

SRHMM001415-2 R Substrate 1 R Substrate 1 S Substrate 2 Y Substrate 2 1 PIRSR001415-3 Domain

PIRSF001415 Archaea Fungi Ascomycota Amoebozoa Viridiplantae Bacteria

SRHMM001415-3 FTGRP_1 Metal-binding Zinc SRHMM001415-3 C Zinc; catalytic C Zinc; catalytic C Zinc; catalytic 1 PIRSR001415-4 Domain

PIRSF001415 Archaea Metazoa Bacteria

SRHMM001415-4 C Zinc 1; catalytic C Zinc 1; catalytic H Zinc 2 C Zinc 1; catalytic C Zinc 2 1 PIRSR001415-5 Domain

PIRSF001415 Archaea Fungi Ascomycota Amoebozoa Viridiplantae Bacteria

SRHMM001415-5 FTGRP_1 Metal-binding Magnesium SRHMM001415-5 E Magnesium 1 PIRSR001426-1 Domain

PIRSF001426 Bacteria

SRHMM001426-1 FTGRP_1 SRHMM001426-1 FTGRP_2 SRHMM001426-1 FTGRP_3 SRHMM001426-1 FTGRP_4 Iron Metal-binding SRHMM001426-1 C Iron SRHMM001426-1 S Iron SRHMM001426-1 C Iron SRHMM001426-1 C Iron 1 PIRSR001430-1 Domain

PIRSF001430 Archaea Eukaryota Bacteria

SRHMM001430-1 D Nucleophile 1 PIRSR001430-2 Domain

PIRSF001430 Archaea Eukaryota Bacteria

SRHMM001430-2 Y Substrate 1 PIRSR001430-3 Domain

PIRSF001430 Archaea Eukaryota Bacteria

SRHMM001430-3 R Interaction with tRNA; Important for base-flipping R Interaction with tRNA R Interaction with tRNA R Interaction with tRNA F Interaction with tRNA Q-x(3)-R Interaction with tRNA 1 PIRSR001434-2 Domain

PIRSF001434 Eukaryota Bacteria

SRHMM001434-2 FTGRP_1 Pyridoxal phosphate SRHMM001434-2 K N6-(pyridoxal phosphate)lysine 1 PIRSR001461-1 Domain

PIRSF001461 Archaea Eukaryota Bacteria

SRHMM001461-1 D Proton acceptor SRHMM001461-1 D Proton donor 1 PIRSR001461-2 Domain

PIRSF001461 Archaea Eukaryota Bacteria

SRHMM001461-2 FTGRP_1 SRHMM001461-2 FTGRP_2 SRHMM001461-2 FTGRP_3 SRHMM001461-2 FTGRP_4 Cobalt Manganese Metal-binding Zinc a divalent metal cation Binds 1 divalent metal cation per subunit. SRHMM001461-2 H Divalent metal cation SRHMM001461-2 D Divalent metal cation SRHMM001461-2 H Divalent metal cation SRHMM001461-2 D Divalent metal cation 1 PIRSR001461-3 Domain

PIRSF001461 Archaea Eukaryota Bacteria

SRHMM001461-3 G-x(2)-[GN] Substrate binding SRHMM001461-3 H Substrate SRHMM001461-3 G Substrate; via amide nitrogen SRHMM001461-3 [GA]-[ST] Substrate binding SRHMM001461-3 S Substrate 1 PIRSR001467-1 Domain

PIRSF001467 Eukaryota Bacteria

SRHMM001467-1 H-x(10)-G Cyclosporin A binding T-G Cyclosporin A binding A-x(4)-G Cyclosporin A binding G-x(3)-F Cyclosporin A binding T Cyclosporin A K Cyclosporin A 1 PIRSR001480-1 Domain

PIRSF001480 Eukaryota Bacteria

SRHMM001480-1 R 1 PIRSR001480-2 Domain

PIRSF001480 Eukaryota Bacteria

SRHMM001480-2 FTGRP_1 SRHMM001480-2 FTGRP_2 SRHMM001480-2 FTGRP_3 SRHMM001480-2 FTGRP_4 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM001480-2 H Zinc SRHMM001480-2 E Zinc SRHMM001480-2 H Zinc SRHMM001480-2 Q Zinc 1 PIRSR001488-1 Domain

PIRSF001488 Proteobacteria

SRHMM001488-1 C-x(2)-C Redox-active 1 PIRSR001492-1 Domain

PIRSF001492 Eukaryota Bacteria Archaea

SRHMM001492-1 S Phosphoserine intermediate 1 PIRSR001492-2 Domain

PIRSF001492 Eukaryota Bacteria Archaea

SRHMM001492-2 H Substrate R-D Substrate binding R Substrate [RK] Substrate R-x(2)-R Substrate binding K Substrate 1 PIRSR001492-3 Domain

PIRSF001492 Eukaryota Bacteria Archaea

SRHMM001492-3 FTGRP_1 SRHMM001492-3 FTGRP_2 SRHMM001492-3 FTGRP_3 SRHMM001492-3 FTGRP_4 SRHMM001492-3 FTGRP_5 SRHMM001492-3 FTGRP_6 SRHMM001492-3 FTGRP_7 Manganese Metal-binding Mn(2+) Binds 2 manganese ions per subunit.; SRHMM001492-3 H Manganese 1 SRHMM001492-3 D Manganese 2 SRHMM001492-3 D Manganese 2 SRHMM001492-3 H Manganese 2 SRHMM001492-3 D Manganese 1 SRHMM001492-3 H Manganese 1 SRHMM001492-3 S Manganese 2 1 PIRSR001500-1 Domain

PIRSF001500 Bacteria

SRHMM001500-1 R Substrate R Substrate K Substrate D Substrate E Substrate [SC] Substrate Q Substrate 1 PIRSR001500-2 Domain

PIRSF001500 Bacteria

SRHMM001500-2 T Essential for prephenate dehydratase activity 1 PIRSR001522-1 Domain

PIRSF001522 Bacteria

SRHMM001522-1 D D D H 1 PIRSR001553-1 Domain

PIRSF001553 Archaea Eukaryota Bacteria

SRHMM001553-1 H Tele-phosphohistidine intermediate 1 PIRSR001558-1 Domain

PIRSF001558 Eukaryota

SRHMM001558-1 FTGRP_2 SRHMM001558-1 FTGRP_3 SRHMM001558-1 FTGRP_4 SRHMM001558-1 FTGRP_5 SRHMM001558-1 FTGRP_6 SRHMM001558-1 FTGRP_7 SRHMM001558-1 FTGRP_8 SRHMM001558-1 FTGRP_9 ATP-binding Nucleotide-binding SRHMM001558-1 K ATP SRHMM001558-1 [DE] ATP; via carbonyl oxygen SRHMM001558-1 E ATP SRHMM001558-1 Y ATP SRHMM001558-1 M-x(2)-I ATP SRHMM001558-1 K-x(8)-N ATP SRHMM001558-1 K ATP SRHMM001558-1 R Substrate Q Substrate R Substrate SRHMM001558-1 E ATP 1 PIRSR001558-2 Domain

PIRSF001558 Eukaryota

SRHMM001558-2 FTGRP_1 SRHMM001558-2 FTGRP_2 SRHMM001558-2 FTGRP_3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM001558-2 N Magnesium SRHMM001558-2 E Magnesium SRHMM001558-2 E Magnesium 1 PIRSR001558-3 Domain

PIRSF001558 Eukaryota

SRHMM001558-3 [IV]-x(2)-S Substrate binding [EQ]-x-N Substrate binding R-x(2)-Y Substrate binding V-A Substrate binding 1 PIRSR001569-1 Domain

PIRSF001569 Eukaryota

SRHMM001569-1 C Glycyl thioester intermediate 1 PIRSR001589-1 Domain

PIRSF001589 Viruses Archaea Eukaryota Bacteria

SRHMM001589-1 FTGRP_1 Amino-acid biosynthesis Asparagine biosynthesis Glutamine amidotransferase SRHMM001589-1 C For GATase activity 1 PIRSR001589-2 Domain

PIRSF001589 Eukaryota Bacteria Archaea Viruses

SRHMM001589-2 FTGRP_1 SRHMM001589-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM001589-2 L ATP; via carbonyl oxygen [VI] ATP; via amide nitrogen and carbonyl oxygen S-G ATP SRHMM001589-2 D Glutamine 1 PIRSR001589-3 Domain

PIRSF001589 Eukaryota Bacteria Archaea Viruses

SRHMM001589-3 [ED] Important for beta-aspartyl-AMP intermediate formation 1 PIRSR001594-1 Domain

PIRSF001594 Eukaryota Bacteria

SRHMM001594-1 R 1 PIRSR001594-2 Domain

PIRSF001594 Eukaryota Bacteria

SRHMM001594-2 FTGRP_1 SRHMM001594-2 FTGRP_2 SRHMM001594-2 FTGRP_3 ATP-binding Nucleotide-binding SRHMM001594-2 H ATP SRHMM001594-2 R Substrate T Substrate SRHMM001594-2 K ATP SRHMM001594-2 E ATP 1 PIRSR001594-3 Domain

PIRSF001594 Eukaryota Bacteria

SRHMM001594-3 FTGRP_1 SRHMM001594-3 FTGRP_2 SRHMM001594-3 FTGRP_3 SRHMM001594-3 FTGRP_4 Metal-binding SRHMM001594-3 D Divalent metal cation SRHMM001594-3 H Divalent metal cation SRHMM001594-3 K Divalent metal cation; via carbamate group SRHMM001594-3 H Divalent metal cation 1 PIRSR001600-50 Domain

PIRSF001600 Viruses

SRHMM001600-50 K N6-AMP-lysine intermediate 1 PIRSR001619-1 Domain

PIRSF001619 Archaea Eukaryota Bacteria

SRHMM001619-1 FTGRP_1 SRHMM001619-1 FTGRP_2 SRHMM001619-1 FTGRP_3 4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. SRHMM001619-1 FTGRP_4 SRHMM001619-1 FTGRP_5 SRHMM001619-1 FTGRP_6 SRHMM001619-1 FTGRP_7 2Fe-2S Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. SRHMM001619-1 C Iron-sulfur 1 (4Fe-4S-S-AdoMet) SRHMM001619-1 [RK] Iron-sulfur 2 (2Fe-2S) SRHMM001619-1 [CS] Iron-sulfur 2 (2Fe-2S) SRHMM001619-1 C Iron-sulfur 1 (4Fe-4S-S-AdoMet) SRHMM001619-1 [CS] Iron-sulfur 2 (2Fe-2S) SRHMM001619-1 C Iron-sulfur 2 (2Fe-2S) SRHMM001619-1 C Iron-sulfur 1 (4Fe-4S-S-AdoMet) 1 PIRSR001620-1 Domain

PIRSF001620 Eukaryota

SRHMM001620-1 [KRQ]-A Reactive bond R-G Reactive bond [RQK]-A Reactive bond 1 PIRSR001640-50 Domain

PIRSF001640 Metazoa

SRHMM001640-50 FTGRP_1 Disulfide bond SRHMM001640-50 C-x(7)-C C-x(11)-C C-x(16)-C 1 PIRSR001657-50 Domain

PIRSF001657 Viridiplantae

SRHMM001657-50 FTGRP_1 Disulfide bond SRHMM001657-50 C-x(45)-C C-x(20)-C C-x(54)-C C-x(56)-C C-x(60)-C 1 PIRSR001658-50 Domain

PIRSF001658 Bacteria

SRHMM001658-50 FTGRP_1 Disulfide bond SRHMM001658-50 C-x(15)-C C-x(27)-C 1 PIRSR001667-1 Domain

PIRSF001667 Eukaryota

SRHMM001667-1 R Important for inhibition R Important for inhibition R Important for inhibition 1 PIRSR001787-1 Domain

PIRSF001787 Eukaryota

SRHMM001787-1 FTGRP_1 SRHMM001787-1 FTGRP_2 SRHMM001787-1 FTGRP_3 SRHMM001787-1 FTGRP_4 SRHMM001787-1 FTGRP_5 Disulfide bond SRHMM001787-1 C-x(62)-C SRHMM001787-1 C-x(8)-C SRHMM001787-1 C-x(62)-C SRHMM001787-1 C Interchain SRHMM001787-1 C-x(64)-C 1 PIRSR001789-1 Domain

PIRSF001789 Eukaryota

SRHMM001789-1 FTGRP_1 Disulfide bond SRHMM001789-1 C-x(66)-C C-x(50)-C C-x(42)-C 1 PIRSR001814-1 Domain

PIRSF001814 Eukaryota

SRHMM001814-1 FTGRP_1 Disulfide bond SRHMM001814-1 C-x(10)-C 1 PIRSR001815-50 Domain

PIRSF001815 Metazoa

SRHMM001815-50 FTGRP_1 Disulfide bond SRHMM001815-50 C-x(4)-C C-x(43)-C C-x(13)-C C-x(22)-C C-x(5)-C C-x(11)-C C-x(17)-C C-x(4)-C 1 PIRSR001837-1 Domain

PIRSF001837 Eukaryota

SRHMM001837-1 FTGRP_1 Disulfide bond SRHMM001837-1 C-x(49)-C 1 PIRSR001859-50 Domain

PIRSF001859 Insecta

SRHMM001859-50 FTGRP_1 Disulfide bond SRHMM001859-50 C-x(23)-C C-x(15)-C C-x(27)-C 1 PIRSR001924-1 Domain

PIRSF001924 Bacteria

SRHMM001924-1 E 1 PIRSR001924-3 Domain

PIRSF001924 Bacteria

SRHMM001924-3 FTGRP_1 Disulfide bond SRHMM001924-3 C-x(18)-C 1 PIRSR001935-1 Domain

PIRSF001935 Eukaryota

SRHMM001935-1 FTGRP_1 SRHMM001935-1 FTGRP_2 Disulfide bond SRHMM001935-1 C-x(5)-C SRHMM001935-1 C-x(9)-C 1 PIRSR001939-1 Domain

PIRSF001939 Eukaryota

SRHMM001939-1 FTGRP_1 Disulfide bond SRHMM001939-1 C-x(62)-C 1 PIRSR001941-1 Domain

PIRSF001941 Eukaryota

SRHMM001941-1 FTGRP_1 SRHMM001941-1 FTGRP_2 Disulfide bond SRHMM001941-1 C-x(40)-C SRHMM001941-1 C-x(52)-C 1 PIRSR001942-1 Domain

PIRSF001942 Eukaryota

SRHMM001942-1 FTGRP_1 SRHMM001942-1 FTGRP_2 SRHMM001942-1 FTGRP_3 Disulfide bond SRHMM001942-1 C-x(138)-C SRHMM001942-1 C-x(94)-C SRHMM001942-1 C-x(44)-C 1 PIRSR001948-50 Domain

PIRSF001948 Vertebrata

SRHMM001948-50 FTGRP_1 Disulfide bond SRHMM001948-50 C-x(82)-C C Interchain C-x(90)-C C-x(43)-C C Interchain C Interchain 1 PIRSR001951-1 Domain

PIRSF001951 Eukaryota

SRHMM001951-1 FTGRP_1 SRHMM001951-1 FTGRP_2 Disulfide bond SRHMM001951-1 C-x(3)-C SRHMM001951-1 C-x(153)-C 1 PIRSR001959-1 Domain

PIRSF001959 Eukaryota

SRHMM001959-1 F Required for ligand binding Y Interaction with APS and STAT5, and activation Y Required for STAT5/PTPN11/SOCS3 binding Y Interaction with PTPN6 Y Required for STAT1/STAT3 activation [YF] Required for CrkL binding 1 PIRSR001959-2 Domain

PIRSF001959 Eukaryota

SRHMM001959-2 FTGRP_1 SRHMM001959-2 FTGRP_2 Disulfide bond SRHMM001959-2 C-x(15)-C SRHMM001959-2 C-x(9)-C 1 PIRSR001979-1 Domain

PIRSF001979 Eukaryota

SRHMM001979-1 FTGRP_1 SRHMM001979-1 FTGRP_2 Disulfide bond SRHMM001979-1 C-x(51)-C SRHMM001979-1 C-x(47)-C 1 PIRSR001992-1 Domain

PIRSF001992 Eukaryota

SRHMM001992-1 FTGRP_1 SRHMM001992-1 FTGRP_2 SRHMM001992-1 FTGRP_3 Disulfide bond SRHMM001992-1 C-x(6)-C SRHMM001992-1 C-x(18)-C SRHMM001992-1 C-x(18)-C 1 PIRSR001997-1 Domain

PIRSF001997 Eukaryota

SRHMM001997-1 C Phosphocysteine intermediate 1 PIRSR002004-1 Domain

PIRSF002004 Eukaryota

SRHMM002004-1 C Phosphocysteine intermediate C Phosphocysteine intermediate 1 PIRSR002006-1 Domain

PIRSF002006 Eukaryota

SRHMM002006-1 C Phosphocysteine intermediate C Phosphocysteine intermediate 1 PIRSR002006-2 Domain

PIRSF002006 Eukaryota

SRHMM002006-2 D Substrate C-x(5)-R Substrate binding Q Substrate 1 PIRSR002006-3 Domain

PIRSF002006 Eukaryota

SRHMM002006-3 FTGRP_1 Phosphoprotein SRHMM002006-3 Y Phosphotyrosine 1 PIRSR002017-1 Domain

PIRSF002017 Eukaryota

SRHMM002017-1 FTGRP_1 SRHMM002017-1 FTGRP_2 SRHMM002017-1 FTGRP_3 SRHMM002017-1 FTGRP_4 Disulfide bond SRHMM002017-1 C-x(16)-C SRHMM002017-1 C-x(10)-C SRHMM002017-1 C-x(29)-C SRHMM002017-1 C-x(30)-C 1 PIRSR002023-50 Domain

PIRSF002023 Serpentes

SRHMM002023-50 FTGRP_1 Disulfide bond SRHMM002023-50 C-x(23)-C C-x(6)-C C-x(27)-C C-x(20)-C C-x(4)-C C-x(24)-C C-x(28)-C C-x(21)-C 1 PIRSR002026-1 Domain

PIRSF002026 Eukaryota

SRHMM002026-1 FTGRP_1 Iron Metal-binding SRHMM002026-1 H Iron (heme proximal ligand) 1 PIRSR002030-1 Domain

PIRSF002030 Eukaryota Bacteria

SRHMM002030-1 FTGRP_1 Heme Iron Metal-binding heme Binds 1 heme group per subunit. SRHMM002030-1 H Iron (heme proximal ligand) 1 PIRSR002033-1 Domain

PIRSF002033 Eukaryota

SRHMM002033-1 FTGRP_1 SRHMM002033-1 FTGRP_2 SRHMM002033-1 FTGRP_3 SRHMM002033-1 FTGRP_4 SRHMM002033-1 FTGRP_5 SRHMM002033-1 FTGRP_6 SRHMM002033-1 FTGRP_7 SRHMM002033-1 FTGRP_8 SRHMM002033-1 FTGRP_9 Iron Metal-binding SRHMM002033-1 H Iron 1 SRHMM002033-1 D Iron 1 SRHMM002033-1 H Iron 1 SRHMM002033-1 D Iron 2 SRHMM002033-1 E Iron 2 SRHMM002033-1 H Iron 2 SRHMM002033-1 H Iron 2 SRHMM002033-1 H Iron 2 SRHMM002033-1 E Iron 1 1 PIRSR002096-1 Domain

PIRSF002096 Bacteria

SRHMM002096-1 Q-x(4)-[ASKR] 1 PIRSR002279-1 Domain

PIRSF002279 Eukaryota

SRHMM002279-1 FTGRP_1 SRHMM002279-1 FTGRP_2 SRHMM002279-1 FTGRP_3 SRHMM002279-1 FTGRP_4 SRHMM002279-1 FTGRP_5 SRHMM002279-1 FTGRP_6 SRHMM002279-1 FTGRP_7 SRHMM002279-1 FTGRP_8 SRHMM002279-1 FTGRP_9 SRHMM002279-1 FTGRP_10 SRHMM002279-1 FTGRP_11 SRHMM002279-1 FTGRP_12 Calcium Metal-binding SRHMM002279-1 N Calcium 3 SRHMM002279-1 D Calcium 3 SRHMM002279-1 K Calcium 3; via carbonyl oxygen SRHMM002279-1 D Calcium 2 SRHMM002279-1 V Calcium 2; via carbonyl oxygen SRHMM002279-1 T Calcium 3; via carbonyl oxygen SRHMM002279-1 E Calcium 2 SRHMM002279-1 E Calcium 3 SRHMM002279-1 S Calcium 1; via amide nitrogen SRHMM002279-1 D Calcium 2 SRHMM002279-1 T Calcium 1; via carbonyl oxygen SRHMM002279-1 Q Calcium 2; via carbonyl oxygen 1 PIRSR002279-2 Domain

PIRSF002279 Eukaryota

SRHMM002279-2 FTGRP_1 SRHMM002279-2 FTGRP_2 SRHMM002279-2 FTGRP_3 SRHMM002279-2 FTGRP_4 SRHMM002279-2 FTGRP_5 SRHMM002279-2 FTGRP_6 SRHMM002279-2 FTGRP_7 SRHMM002279-2 FTGRP_8 SRHMM002279-2 FTGRP_9 Disulfide bond SRHMM002279-2 C-x(14)-C SRHMM002279-2 C-x(10)-C SRHMM002279-2 C-x(14)-C SRHMM002279-2 C-x(8)-C SRHMM002279-2 C-x(12)-C SRHMM002279-2 C-x(14)-C SRHMM002279-2 C-x(8)-C SRHMM002279-2 C-x(10)-C SRHMM002279-2 C-x(8)-C 1 PIRSR002305-1 Domain

PIRSF002305 Metazoa

SRHMM002305-1 K-x(2)-K Phosphatidylinositol binding K Phosphatidylinositol 1 PIRSR002356-1 Domain

PIRSF002356 Eukaryota

SRHMM002356-1 Y Carbohydrate K Carbohydrate Y Carbohydrate D Carbohydrate [DE] Carbohydrate 1 PIRSR002356-2 Domain

PIRSF002356 Eukaryota

SRHMM002356-2 FTGRP_1 SRHMM002356-2 FTGRP_2 SRHMM002356-2 FTGRP_3 SRHMM002356-2 FTGRP_4 Calcium Metal-binding SRHMM002356-2 K Calcium; via carbonyl oxygen SRHMM002356-2 K Calcium; via carbonyl oxygen SRHMM002356-2 Q Calcium; via carbonyl oxygen SRHMM002356-2 D Calcium 1 PIRSR002356-3 Domain

PIRSF002356 Eukaryota

SRHMM002356-3 C-x(31)-C 1 PIRSR002374-1 Domain

PIRSF002374 Eukaryota

SRHMM002374-1 F-M Cleavage; by chymosin/rennin 1 PIRSR002395-1 Domain

PIRSF002395 Eukaryota

SRHMM002395-1 K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) 1 PIRSR002412-1 Domain

PIRSF002412 Eukaryota

SRHMM002412-1 I-x(8)-F Acyl-CoA binding Y-x(3)-K Acyl-CoA binding K Acyl-CoA Y Acyl-CoA 1 PIRSR002417-50 Domain

PIRSF002417 Eukaryota

SRHMM002417-50 FTGRP_1 Disulfide bond SRHMM002417-50 C-x(39)-C 1 PIRSR002421-1 Domain

PIRSF002421 Eukaryota

SRHMM002421-1 FTGRP_1 SRHMM002421-1 FTGRP_2 SRHMM002421-1 FTGRP_3 SRHMM002421-1 FTGRP_4 SRHMM002421-1 FTGRP_5 SRHMM002421-1 FTGRP_6 SRHMM002421-1 FTGRP_7 SRHMM002421-1 FTGRP_8 SRHMM002421-1 FTGRP_9 Disulfide bond SRHMM002421-1 C-x(43)-C SRHMM002421-1 C-x(43)-C SRHMM002421-1 C-x(18)-C SRHMM002421-1 C-x(8)-C SRHMM002421-1 C-x(26)-C SRHMM002421-1 C-x(10)-C SRHMM002421-1 C-x(97)-C SRHMM002421-1 C-x(14)-C SRHMM002421-1 C-x(26)-C 1 PIRSR002421-2 Domain

PIRSF002421 Eukaryota

SRHMM002421-2 FTGRP_1 SRHMM002421-2 FTGRP_2 SRHMM002421-2 FTGRP_3 SRHMM002421-2 FTGRP_4 SRHMM002421-2 FTGRP_5 Calcium Metal-binding SRHMM002421-2 E Calcium SRHMM002421-2 E Calcium SRHMM002421-2 D Calcium SRHMM002421-2 N Calcium SRHMM002421-2 N Calcium 1 PIRSR002421-3 Domain

PIRSF002421 Eukaryota

SRHMM002421-3 N-x-[T] N-linked (GlcNAc...) asparagine N-x-[ST] N-linked (GlcNAc...) asparagine N-x-[T] N-linked (GlcNAc...) asparagine 1 PIRSR002431-1 Domain

PIRSF002431 Eukaryota

SRHMM002431-1 FTGRP_1 SRHMM002431-1 FTGRP_2 SRHMM002431-1 FTGRP_3 SRHMM002431-1 FTGRP_4 SRHMM002431-1 FTGRP_5 SRHMM002431-1 FTGRP_6 SRHMM002431-1 FTGRP_7 SRHMM002431-1 FTGRP_8 SRHMM002431-1 FTGRP_9 SRHMM002431-1 FTGRP_10 SRHMM002431-1 FTGRP_11 SRHMM002431-1 FTGRP_12 Disulfide bond SRHMM002431-1 C-x(74)-C SRHMM002431-1 C-x(63)-C SRHMM002431-1 C-x(72)-C SRHMM002431-1 C-x(10)-C SRHMM002431-1 C-x(72)-C SRHMM002431-1 C-x(65)-C SRHMM002431-1 C-x(10)-C SRHMM002431-1 C-x(63)-C SRHMM002431-1 C-x(11)-C SRHMM002431-1 C-x(10)-C SRHMM002431-1 C-x(63)-C SRHMM002431-1 C-x(72)-C 1 PIRSR002486-1 Domain

PIRSF002486 Viruses

SRHMM002486-1 FTGRP_1 SRHMM002486-1 FTGRP_2 SRHMM002486-1 FTGRP_3 SRHMM002486-1 FTGRP_4 SRHMM002486-1 FTGRP_5 SRHMM002486-1 FTGRP_6 SRHMM002486-1 FTGRP_7 SRHMM002486-1 FTGRP_8 Disulfide bond SRHMM002486-1 C-x(26)-C SRHMM002486-1 C-x(30)-C SRHMM002486-1 C-x(48)-C SRHMM002486-1 C-x(39)-C SRHMM002486-1 C-x(26)-C SRHMM002486-1 C-x(41)-C SRHMM002486-1 C-x(41)-C SRHMM002486-1 C-x(24)-C 1 PIRSR002490-1 Domain

PIRSF002490 Eukaryota

SRHMM002490-1 FTGRP_1 SRHMM002490-1 FTGRP_2 SRHMM002490-1 FTGRP_3 Disulfide bond SRHMM002490-1 C-x(32)-C SRHMM002490-1 C-x(8)-C SRHMM002490-1 C-x(5)-C 1 PIRSR002495-50 Domain

PIRSF002495 Eutheria

SRHMM002495-50 FTGRP_1 Disulfide bond SRHMM002495-50 C-x(40)-C C-x(27)-C C-x(10)-C C-x(128)-C C-x(141)-C C-x(94)-C C-x(6)-C C-x(23)-C C-x(39)-C C-x(1)-C C-x(3)-C C-x(19)-C C-x(11)-C C-x(2)-C C-x(2)-C C-x(185)-C C-C C-x(185)-C C-x(24)-C C-x(40)-C C-x(160)-C C-x(134)-C C-x(150)-C C-x(7)-C C-x(49)-C C-x(48)-C C-x(53)-C C-x(51)-C 1 PIRSR002498-1 Domain

PIRSF002498 Eukaryota

SRHMM002498-1 FTGRP_1 SRHMM002498-1 FTGRP_2 Disulfide bond SRHMM002498-1 C-x(22)-C SRHMM002498-1 C-x(7)-C 1 PIRSR002498-2 Domain

PIRSF002498 Eukaryota

SRHMM002498-2 FTGRP_1 Disulfide bond SRHMM002498-2 C S-palmitoyl cysteine 1 PIRSR002512-1 Domain

PIRSF002512 Eukaryota

SRHMM002512-1 FTGRP_1 SRHMM002512-1 FTGRP_2 SRHMM002512-1 FTGRP_3 SRHMM002512-1 FTGRP_4 SRHMM002512-1 FTGRP_5 SRHMM002512-1 FTGRP_6 SRHMM002512-1 FTGRP_7 SRHMM002512-1 FTGRP_8 SRHMM002512-1 FTGRP_9 SRHMM002512-1 FTGRP_10 SRHMM002512-1 FTGRP_11 SRHMM002512-1 FTGRP_12 SRHMM002512-1 FTGRP_13 SRHMM002512-1 FTGRP_14 SRHMM002512-1 FTGRP_15 SRHMM002512-1 FTGRP_16 SRHMM002512-1 FTGRP_17 SRHMM002512-1 FTGRP_18 SRHMM002512-1 FTGRP_19 SRHMM002512-1 FTGRP_20 SRHMM002512-1 FTGRP_21 SRHMM002512-1 FTGRP_22 SRHMM002512-1 FTGRP_23 SRHMM002512-1 FTGRP_24 SRHMM002512-1 FTGRP_25 SRHMM002512-1 FTGRP_26 SRHMM002512-1 FTGRP_27 SRHMM002512-1 FTGRP_28 Disulfide bond SRHMM002512-1 C-x(4)-C SRHMM002512-1 C-x(47)-C SRHMM002512-1 C-x(3)-C SRHMM002512-1 C-x(4)-C SRHMM002512-1 C-x(4)-C SRHMM002512-1 C-x(32)-C SRHMM002512-1 C-x(248)-C SRHMM002512-1 C-x(4)-C SRHMM002512-1 C-x(8)-C SRHMM002512-1 C-x(12)-C SRHMM002512-1 C-x(37)-C SRHMM002512-1 C-x(40)-C SRHMM002512-1 C-x(8)-C SRHMM002512-1 C-x(12)-C SRHMM002512-1 C-x(9)-C SRHMM002512-1 C-x(429)-C SRHMM002512-1 C-x(11)-C SRHMM002512-1 C-x(6)-C SRHMM002512-1 C-x(6)-C SRHMM002512-1 C-x(30)-C SRHMM002512-1 C-x(11)-C SRHMM002512-1 C-x(11)-C SRHMM002512-1 C-x(72)-C SRHMM002512-1 C-x(27)-C SRHMM002512-1 C-x(8)-C SRHMM002512-1 C-x(32)-C SRHMM002512-1 C-x(2)-C SRHMM002512-1 C-x(9)-C 1 PIRSR002520-1 Domain

PIRSF002520 Eukaryota

SRHMM002520-1 FTGRP_1 SRHMM002520-1 FTGRP_2 SRHMM002520-1 FTGRP_3 SRHMM002520-1 FTGRP_4 Metal-binding Zinc SRHMM002520-1 H Zinc SRHMM002520-1 D Zinc SRHMM002520-1 N Zinc SRHMM002520-1 H Zinc 1 PIRSR002520-2 Domain

PIRSF002520 Eukaryota

SRHMM002520-2 FTGRP_1 SRHMM002520-2 FTGRP_2 SRHMM002520-2 FTGRP_3 SRHMM002520-2 FTGRP_4 SRHMM002520-2 FTGRP_5 SRHMM002520-2 FTGRP_6 SRHMM002520-2 FTGRP_7 SRHMM002520-2 FTGRP_8 SRHMM002520-2 FTGRP_9 SRHMM002520-2 FTGRP_10 SRHMM002520-2 FTGRP_11 SRHMM002520-2 FTGRP_12 SRHMM002520-2 FTGRP_13 SRHMM002520-2 FTGRP_14 SRHMM002520-2 FTGRP_15 SRHMM002520-2 FTGRP_16 SRHMM002520-2 FTGRP_17 Disulfide bond SRHMM002520-2 C-x(44)-C SRHMM002520-2 C-x(15)-C SRHMM002520-2 C-x(8)-C SRHMM002520-2 C-x(7)-C SRHMM002520-2 C-x(45)-C SRHMM002520-2 C-x(10)-C SRHMM002520-2 C-x(10)-C SRHMM002520-2 C-x(15)-C SRHMM002520-2 C-x(45)-C SRHMM002520-2 C-x(44)-C SRHMM002520-2 C-x(8)-C SRHMM002520-2 C-x(13)-C SRHMM002520-2 C-x(10)-C SRHMM002520-2 C-x(8)-C SRHMM002520-2 C-x(44)-C SRHMM002520-2 C-x(10)-C SRHMM002520-2 C-x(8)-C 1 PIRSR002520-3 Domain

PIRSF002520 Eukaryota

SRHMM002520-3 FTGRP_1 Disulfide bond SRHMM002520-3 K Bilirubin 1 PIRSR002520-4 Domain

PIRSF002520 Eukaryota

SRHMM002520-4 FTGRP_1 Disulfide bond SRHMM002520-4 K Aspirin-acetylated lysine 1 PIRSR002530-1 Domain

PIRSF002530 Eukaryota

SRHMM002530-1 Y Phosphatidylglycerol phosphate SRHMM002530-1 G-x(2)-L Phosphatidylglycerol phosphate binding SRHMM002530-1 K Phosphatidylglycerol phosphate 1 PIRSR002549-1 Domain

PIRSF002549 Eukaryota

SRHMM002549-1 K S Nucleophile 1 PIRSR002551-1 Domain

PIRSF002551 Eukaryota

SRHMM002551-1 FTGRP_1 Disulfide bond SRHMM002551-1 C-x(180)-C C-x(4)-C C-x(11)-C C-x(41)-C 1 PIRSR002551-2 Domain

PIRSF002551 Eukaryota

SRHMM002551-2 FTGRP_1 SRHMM002551-2 FTGRP_2 SRHMM002551-2 FTGRP_3 SRHMM002551-2 FTGRP_4 Heme Iron Metal-binding SRHMM002551-2 H Iron (heme 2 axial ligand) SRHMM002551-2 H Iron (heme 1 axial ligand) SRHMM002551-2 H Iron (heme 2 axial ligand) SRHMM002551-2 H Iron (heme 1 axial ligand) 1 PIRSR002551-3 Domain

PIRSF002551 Eukaryota

SRHMM002551-3 N N-linked (GlcNAc...) asparagine 1 PIRSR002560-1 Domain

PIRSF002560 Bacteria

SRHMM002560-1 FTGRP_1 SRHMM002560-1 FTGRP_2 SRHMM002560-1 FTGRP_3 SRHMM002560-1 FTGRP_4 SRHMM002560-1 FTGRP_5 SRHMM002560-1 FTGRP_6 SRHMM002560-1 FTGRP_7 SRHMM002560-1 FTGRP_8 SRHMM002560-1 FTGRP_9 Iron Metal-binding SRHMM002560-1 M Iron (heme axial ligand); shared with dimeric partner SRHMM002560-1 H Iron 1 SRHMM002560-1 E Iron 1 E Iron 2 SRHMM002560-1 H Iron 2 SRHMM002560-1 [DE] Iron 3 SRHMM002560-1 E Iron 1 E Iron 2 SRHMM002560-1 E Iron 1 SRHMM002560-1 E Iron 2 SRHMM002560-1 H Iron 3 1 PIRSR002572-1 Domain

PIRSF002572 Eukaryota

SRHMM002572-1 FTGRP_1 SRHMM002572-1 FTGRP_2 Disulfide bond SRHMM002572-1 C-x(33)-C SRHMM002572-1 C-x(25)-C 1 PIRSR002572-2 Domain

PIRSF002572 Eukaryota

SRHMM002572-2 Q Pyrrolidone carboxylic acid 1 PIRSR002703-1 Domain

PIRSF002703 Eukaryota

SRHMM002703-1 FTGRP_1 SRHMM002703-1 FTGRP_2 SRHMM002703-1 FTGRP_3 SRHMM002703-1 FTGRP_4 SRHMM002703-1 FTGRP_5 SRHMM002703-1 FTGRP_6 SRHMM002703-1 FTGRP_7 SRHMM002703-1 FTGRP_8 Disulfide bond SRHMM002703-1 C-x(8)-C SRHMM002703-1 C-x(9)-C SRHMM002703-1 C-x(71)-C SRHMM002703-1 C-x(9)-C SRHMM002703-1 C-x(5)-C SRHMM002703-1 C-x(194)-C SRHMM002703-1 C-x(4)-C SRHMM002703-1 C-x(49)-C 1 PIRSR002736-50 Domain This rule was created based on analysis for RESID:AA0167.

PIRSF002736 Bacteria

SRHMM002736-50 FTGRP_1 Phosphoprotein SRHMM002736-50 S O-(phosphoribosyl dephospho-coenzyme A)serine 1 PIRSR002756-1 Domain

PIRSF002756 Bacteria

SRHMM002756-1 S-x-A Phosphate binding S Phosphate D Phosphate S-x-T Phosphate binding 1 PIRSR002799-1 Domain

PIRSF002799 Proteobacteria

SRHMM002799-1 E Proton donor; for transglycosylase activity S Acyl-ester intermediate; for transpeptidase activity 1 PIRSR002811-1 Domain

PIRSF002811 Bacteria

SRHMM002811-1 FTGRP_1 Metal-binding Zinc Zinc-finger Zn(2+) Binds 1 zinc ion per monomer. SRHMM002811-1 C-x(2)-H-x(17)-C-x(2)-C CHC2-type 1 PIRSR002816-1 Domain

PIRSF002816 Bacteria

SRHMM002816-1 C The binding site for the sugar molecule has not yet been established, but C-87 may be involved 1 PIRSR002825-1 Domain

PIRSF002825 Bacteria

SRHMM002825-1 FTGRP_1 SRHMM002825-1 FTGRP_2 SRHMM002825-1 FTGRP_3 SRHMM002825-1 FTGRP_4 Iron Metal-binding SRHMM002825-1 Y Iron SRHMM002825-1 H Iron SRHMM002825-1 E Iron SRHMM002825-1 Y Iron 1 PIRSR002854-1 Domain

PIRSF002854 Bacteria

SRHMM002854-1 C S-diacylglycerol cysteine 1 PIRSR002855-1 Domain

PIRSF002855 Bacteria

SRHMM002855-1 FTGRP_1 Peptidoglycan-anchor SRHMM002855-1 K N6-murein peptidoglycan lysine 1 PIRSR002855-2 Domain

PIRSF002855 Bacteria

SRHMM002855-2 FTGRP_1 Palmitate Lipoprotein SRHMM002855-2 C N-palmitoyl cysteine C S-diacylglycerol cysteine 1 PIRSR002884-1 Domain

PIRSF002884 Bacteria

SRHMM002884-1 Q Enhances dephosphorylation of CheY-P 1 PIRSR002900-1 Domain

PIRSF002900 Bacteria

SRHMM002900-1 FTGRP_1 SRHMM002900-1 FTGRP_2 Magnesium Metal-binding SRHMM002900-1 H Magnesium (bacteriochlorophyll axial ligand) SRHMM002900-1 H Magnesium (bacteriochlorophyll axial ligand) 1 PIRSR002937-1 Domain

PIRSF002937 Bacteria

SRHMM002937-1 FTGRP_1 SRHMM002937-1 FTGRP_2 SRHMM002937-1 FTGRP_3 Calcium Metal-binding Ca(2+) Binds 1 Ca(2+) ion per subunit. SRHMM002937-1 D Calcium SRHMM002937-1 D Calcium SRHMM002937-1 D Calcium 1 PIRSR003033-1 Domain

PIRSF003033 Eukaryota

SRHMM003033-1 K Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity 1 PIRSR003047-1 Domain

PIRSF003047 Eukaryota

SRHMM003047-1 FTGRP_1 Disulfide bond SRHMM003047-1 C-x(254)-C 1 PIRSR003047-2 Domain

PIRSF003047 Eukaryota

SRHMM003047-2 K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) 1 PIRSR003048-1 Domain

PIRSF003048 Eukaryota

SRHMM003048-1 E Proton donor/acceptor 1 PIRSR003048-2 Domain

PIRSF003048 Eukaryota

SRHMM003048-2 C-x-V Acetyl-CoA binding Q-x(5)-T Acetyl-CoA binding Y-x(2)-G Acetyl-CoA binding 1 PIRSR003059-1 Domain

PIRSF003059 Bacteria

SRHMM003059-1 D Nucleophile E Proton donor 1 PIRSR003059-2 Domain

PIRSF003059 Bacteria

SRHMM003059-2 D Substrate H Substrate R-x-D Substrate binding E Substrate H-D Substrate binding D-x(2)-Q Substrate binding R Substrate 1 PIRSR003085-1 Domain

PIRSF003085 Bacteria

SRHMM003085-1 C 1 PIRSR003085-2 Domain

PIRSF003085 Bacteria

SRHMM003085-2 Y-[ST] S-adenosyl-L-methionine binding [LVI]-x(7)-G S-adenosyl-L-methionine binding T-x(4)-Q S-adenosyl-L-methionine binding [WY]-E S-adenosyl-L-methionine binding 1 PIRSR003170-1 Domain

PIRSF003170 Eukaryota Bacteria

SRHMM003170-1 E Proton donor 1 PIRSR003170-2 Domain

PIRSF003170 Eukaryota Bacteria

SRHMM003170-2 D Substrate E Substrate E Substrate 1 PIRSR003182-50 Domain This rule was created based on analysis for RESID:AA0033.

PIRSF003182 Bacteria

SRHMM003182-50 FTGRP_1 Phosphoprotein Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain. SRHMM003182-50 H Phosphohistidine; by autocatalysis D 4-aspartylphosphate H Phosphohistidine 1 PIRSR003726-1 Domain

PIRSF003726 Viruses

SRHMM003726-1 K For methyltransferase activity 1 PIRSR003726-2 Domain

PIRSF003726 Viruses

SRHMM003726-2 Q S-adenosyl-L-methionine Y S-adenosyl-L-methionine G S-adenosyl-L-methionine; via carbonyl oxygen G S-adenosyl-L-methionine; via amide nitrogen D S-adenosyl-L-methionine [RK] S-adenosyl-L-methionine [VA] S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen D S-adenosyl-L-methionine 1 PIRSR003726-3 Domain

PIRSF003726 Viruses

SRHMM003726-3 Y mRNA cap R-x(2)-F mRNA cap binding D mRNA cap S-x-E mRNA cap binding E mRNA cap 1 PIRSR003817-1 Domain

PIRSF003817 Viruses

SRHMM003817-1 H Charge relay system; for serine protease NS3 activity D Charge relay system; for serine protease NS3 activity S Charge relay system; for serine protease NS3 activity 1 PIRSR003817-2 Domain

PIRSF003817 Viruses

SRHMM003817-2 S S-adenosyl-L-methionine G S-adenosyl-L-methionine; via carbonyl oxygen W S-adenosyl-L-methionine; via carbonyl oxygen T S-adenosyl-L-methionine K S-adenosyl-L-methionine; via carbonyl oxygen D S-adenosyl-L-methionine [VI] S-adenosyl-L-methionine; via carbonyl oxygen Y S-adenosyl-L-methionine 1 PIRSR003817-3 Domain

PIRSF003817 Viruses

SRHMM003817-3 FTGRP_1 SRHMM003817-3 FTGRP_2 SRHMM003817-3 FTGRP_3 SRHMM003817-3 FTGRP_4 SRHMM003817-3 FTGRP_5 SRHMM003817-3 FTGRP_6 Disulfide bond SRHMM003817-3 C-x(26)-C SRHMM003817-3 C-x(97)-C SRHMM003817-3 C-x(55)-C SRHMM003817-3 C-x(30)-C SRHMM003817-3 C-x(28)-C SRHMM003817-3 C-x(30)-C 1 PIRSR003817-4 Domain

PIRSF003817 Viruses

SRHMM003817-4 FTGRP_1 SRHMM003817-4 FTGRP_2 SRHMM003817-4 FTGRP_3 SRHMM003817-4 FTGRP_4 SRHMM003817-4 FTGRP_5 SRHMM003817-4 FTGRP_6 SRHMM003817-4 FTGRP_7 Metal-binding Zinc SRHMM003817-4 H Zinc 2; via tele nitrogen SRHMM003817-4 C Zinc 1 SRHMM003817-4 C Zinc 2 SRHMM003817-4 E Zinc 1 SRHMM003817-4 C Zinc 1 SRHMM003817-4 C Zinc 2 SRHMM003817-4 H Zinc 1; via tele nitrogen 1 PIRSR003888-1 Domain

PIRSF003888 Viruses

SRHMM003888-1 FTGRP_1 SRHMM003888-1 FTGRP_2 SRHMM003888-1 FTGRP_3 SRHMM003888-1 FTGRP_4 SRHMM003888-1 FTGRP_5 SRHMM003888-1 FTGRP_6 Phosphoprotein SRHMM003888-1 T Phosphothreonine; by host SRHMM003888-1 S Phosphoserine; by host SRHMM003888-1 S Phosphoserine; by host SRHMM003888-1 T Phosphothreonine; by host SRHMM003888-1 S Phosphoserine; by host SRHMM003888-1 S Phosphoserine; by host 1 PIRSR004030-1 Domain

PIRSF004030 Viruses

SRHMM004030-1 FTGRP_1 Myristate SRHMM004030-1 G N-myristoyl glycine; by host 1 PIRSR004131-1 Domain

PIRSF004131 Viruses

SRHMM004131-1 FTGRP_1 SRHMM004131-1 FTGRP_2 SRHMM004131-1 FTGRP_3 Magnesium Metal-binding SRHMM004131-1 Y Magnesium SRHMM004131-1 D Magnesium SRHMM004131-1 G Magnesium; via carbonyl oxygen 1 PIRSR004532-1 Domain

PIRSF004532 Bacteria

SRHMM004532-1 FTGRP_1 Manganese Metal-binding Mn(2+) SRHMM004532-1 D Manganese 1 E Manganese 1 D Manganese 2 [ED] Manganese 2 E Manganese 2 1 PIRSR004532-2 Domain

PIRSF004532 Bacteria

SRHMM004532-2 [ED]-x-T Substrate binding Y Substrate [KR]-x-R Substrate binding D-x-D Substrate binding G Substrate; via amide nitrogen 1 PIRSR004576-50 Domain This rule was created based on analysis for RESID:AA0323.

PIRSF004576 Bacteria

SRHMM004576-50 Y O-(3'-phospho-DNA)-tyrosine intermediate 1 PIRSR004682-1 Domain

PIRSF004682 Bacteria

SRHMM004682-1 D Nucleophile D Proton donor 1 PIRSR004682-2 Domain

PIRSF004682 Bacteria

SRHMM004682-2 D-x-D Substrate binding [DEN]-x(2)-[YF] Substrate binding [TS]-x(2)-[SA] Substrate binding R-K Substrate binding K Substrate 1 PIRSR004682-3 Domain

PIRSF004682 Bacteria

SRHMM004682-3 [TS] Stabilizes the phosphoryl group R Contributes to substrate recognition K Stabilizes the phosphoryl group 1 PIRSR004682-4 Domain

PIRSF004682 Bacteria

SRHMM004682-4 FTGRP_3 SRHMM004682-4 FTGRP_4 SRHMM004682-4 FTGRP_5 SRHMM004682-4 FTGRP_6 Metal-binding Zinc Zn(2+) SRHMM004682-4 FTGRP_1 SRHMM004682-4 FTGRP_2 SRHMM004682-4 FTGRP_7 SRHMM004682-4 FTGRP_8 Magnesium Metal-binding Mg(2+) SRHMM004682-4 H Zinc; via pros nitrogen SRHMM004682-4 C Zinc SRHMM004682-4 C Zinc SRHMM004682-4 D Magnesium SRHMM004682-4 D Magnesium SRHMM004682-4 C Zinc SRHMM004682-4 D Magnesium; via carbonyl oxygen SRHMM004682-4 K Magnesium 1 PIRSR004692-1 Domain

PIRSF004692 Bacteria

SRHMM004692-1 H Substrate H Substrate T Substrate D Substrate 1 PIRSR004692-2 Domain

PIRSF004692 Bacteria

SRHMM004692-2 FTGRP_1 Metal-binding Zinc SRHMM004692-2 H Zinc 1 PIRSR004692-3 Domain

PIRSF004692 Eukaryota Bacteria

SRHMM004692-3 K Catalytically relevant [ED] Catalytically relevant E Catalytically relevant H Catalytically relevant 1 PIRSR004776-1 Domain

PIRSF004776 Bacteria

SRHMM004776-1 FTGRP_1 SRHMM004776-1 FTGRP_2 SRHMM004776-1 FTGRP_3 SRHMM004776-1 FTGRP_4 SRHMM004776-1 FTGRP_5 SRHMM004776-1 FTGRP_6 SRHMM004776-1 FTGRP_7 SRHMM004776-1 FTGRP_8 Nucleotide-binding SRHMM004776-1 [ST]-x-E NAD 1 SRHMM004776-1 E-x(12)-W NAD 1 SRHMM004776-1 S-x-W NAD 2 SRHMM004776-1 R NAD 1 SRHMM004776-1 H NAD 1 SRHMM004776-1 F-x(2)-F NAD 1 SRHMM004776-1 [FM]-x-[VI] NAD 1 SRHMM004776-1 Y-x(2)-Y NAD 2 1 PIRSR004789-50 Domain

PIRSF004789 Bacteria

SRHMM004789-50 H Proton donor 1 PIRSR004789-51 Domain

PIRSF004789 Bacteria

SRHMM004789-51 FTGRP_1 Metal-binding SRHMM004789-51 D Divalent metal cation 1 E Divalent metal cation 1 E Divalent metal cation 2 N Divalent metal cation 1 [ND] Divalent metal cation 2 H Divalent metal cation 2; via tele nitrogen H Divalent metal cation 2; via pros nitrogen H Divalent metal cation 1; via tele nitrogen 1 PIRSR004803-2 Domain

PIRSF004803 Bacteria

SRHMM004803-2 H-x(3)-H Substrate binding 1 PIRSR004846-1 Domain

PIRSF004846 Bacteria

SRHMM004846-1 FTGRP_2 SRHMM004846-1 FTGRP_1 SRHMM004846-1 FTGRP_3 SRHMM004846-1 FTGRP_4 SRHMM004846-1 FTGRP_5 Metal-binding Molybdenum SRHMM004846-1 A Molybdate; via amide nitrogen SRHMM004846-1 [VIM] Molybdate; via amide nitrogen SRHMM004846-1 [ST] Molybdate SRHMM004846-1 Y Molybdate SRHMM004846-1 S Molybdate 1 PIRSR004848-1 Domain

PIRSF004848 Eukaryota Bacteria

SRHMM004848-1 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM004848-1 K N6-(pyridoxal phosphate)lysine 1 PIRSR004869-50 Domain This rule was created based on analysis for RESID:AA0356.

PIRSF004869 Eukaryota Bacteria Archaea

SRHMM004869-50 FTGRP_1 Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. SRHMM004869-50 C Iron-sulfur (4Fe-4S-S-AdoMet) C Iron-sulfur (4Fe-4S-S-AdoMet) C Iron-sulfur (4Fe-4S-S-AdoMet) 1 PIRSR004911-1 Domain

PIRSF004911 Bacteria Archaea

SRHMM004911-1 FTGRP_1 SRHMM004911-1 FTGRP_2 SRHMM004911-1 FTGRP_3 4Fe-4S Iron-sulfur Metal-binding SRHMM004911-1 C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM004911-1 C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM004911-1 C Iron-sulfur (4Fe-4S-S-AdoMet) 1 PIRSR004930-1 Domain

PIRSF004930 Eukaryota Bacteria Archaea

SRHMM004930-1 FTGRP_2 SRHMM004930-1 FTGRP_3 SRHMM004930-1 FTGRP_4 SRHMM004930-1 FTGRP_5 SRHMM004930-1 FTGRP_6 SRHMM004930-1 FTGRP_7 SRHMM004930-1 FTGRP_8 ATP-binding Nucleotide-binding SRHMM004930-1 S ATP; via amide nitrogen SRHMM004930-1 N ATP SRHMM004930-1 Y ATP SRHMM004930-1 R ATP SRHMM004930-1 S ATP SRHMM004930-1 T L-threonine H L-threonine R L-threonine A L-threonine; via carbonyl oxygen S L-threonine SRHMM004930-1 T ATP SRHMM004930-1 R ATP 1 PIRSR005023-1 Domain

PIRSF005023 Bacteria Archaea

SRHMM005023-1 FTGRP_1 SRHMM005023-1 FTGRP_2 SRHMM005023-1 FTGRP_3 SRHMM005023-1 FTGRP_4 SRHMM005023-1 FTGRP_5 SRHMM005023-1 FTGRP_6 4Fe-4S Iron Iron-sulfur Metal-binding SRHMM005023-1 FTGRP_7 SRHMM005023-1 FTGRP_8 SRHMM005023-1 FTGRP_9 SRHMM005023-1 FTGRP_10 SRHMM005023-1 FTGRP_11 SRHMM005023-1 FTGRP_12 4Fe-4S Iron Iron-sulfur Metal-binding Nickel SRHMM005023-1 C Iron-sulfur 2 (4Fe-4S) SRHMM005023-1 C Iron-sulfur 2 (4Fe-4S) SRHMM005023-1 H Nickel-iron-sulfur (Ni-4Fe-4S); via tele nitrogen SRHMM005023-1 C Nickel-iron-sulfur (Ni-4Fe-4S) SRHMM005023-1 C Nickel-iron-sulfur (Ni-4Fe-4S) SRHMM005023-1 C Nickel-iron-sulfur (Ni-4Fe-4S) SRHMM005023-1 C Iron-sulfur 2 (4Fe-4S) SRHMM005023-1 C Iron-sulfur 2 (4Fe-4S) SRHMM005023-1 C Iron-sulfur 1 (4Fe-4S); shared with dimeric partner SRHMM005023-1 C Nickel-iron-sulfur (Ni-4Fe-4S) SRHMM005023-1 C Iron-sulfur 1 (4Fe-4S); shared with dimeric partner SRHMM005023-1 C Nickel-iron-sulfur (Ni-4Fe-4S) 1 PIRSR005054-1 Domain

PIRSF005054 Bacteria Archaea

SRHMM005054-1 K Transition state stabilizer 1 PIRSR005054-50 Domain

PIRSF005054 Bacteria Archaea

SRHMM005054-50 Y Proton acceptor H Proton donor 1 PIRSR005091-1 Domain

PIRSF005091 Bacteria

SRHMM005091-1 [TS] 1 PIRSR005091-2 Domain

PIRSF005091 Bacteria

SRHMM005091-2 FTGRP_1 Manganese Metal-binding SRHMM005091-2 H Substrate 1 PIRSR005091-3 Domain

PIRSF005091 Bacteria

SRHMM005091-3 FTGRP_1 SRHMM005091-3 FTGRP_2 SRHMM005091-3 FTGRP_3 SRHMM005091-3 FTGRP_4 Manganese Metal-binding SRHMM005091-3 H Manganese SRHMM005091-3 D Manganese SRHMM005091-3 E Manganese SRHMM005091-3 T Manganese 1 PIRSR005096-1 Domain

PIRSF005096 Eukaryota Bacteria

SRHMM005096-1 H Proton donor E Proton acceptor 1 PIRSR005096-2 Domain

PIRSF005096 Eukaryota Bacteria

SRHMM005096-2 D Substrate 1 PIRSR005096-3 Domain

PIRSF005096 Eukaryota Bacteria

SRHMM005096-3 N-R Substrate binding SRHMM005096-3 H-x-Y Substrate binding 1 PIRSR005149-50 Domain

PIRSF005149 Eukaryota

SRHMM005149-50 FTGRP_1 Heme Iron Metal-binding Fe cation SRHMM005149-50 H Iron (heme axial ligand) H Iron (heme axial ligand) 1 PIRSR005229-1 Domain

PIRSF005229 Eukaryota Bacteria

SRHMM005229-1 FTGRP_1 SRHMM005229-1 FTGRP_2 SRHMM005229-1 FTGRP_3 SRHMM005229-1 FTGRP_4 SRHMM005229-1 FTGRP_5 SRHMM005229-1 FTGRP_6 Iron Metal-binding Fe cation Binds 2 iron ions per subunit. SRHMM005229-1 E Iron 1 E Iron 2 SRHMM005229-1 E Iron 1 E Iron 2 SRHMM005229-1 H Iron 2 SRHMM005229-1 E Iron 1 SRHMM005229-1 H Iron 1; via pros nitrogen SRHMM005229-1 E Iron 2 1 PIRSR005378-1 Domain

PIRSF005378 Eukaryota

SRHMM005378-1 H Tele-AMP-histidine intermediate 1 PIRSR005378-2 Domain

PIRSF005378 Eukaryota

SRHMM005378-2 FTGRP_1 SRHMM005378-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM005378-2 [YHF]-x(2)-D-Q ATP SRHMM005378-2 Q ATP 1 PIRSR005384-1 Domain

PIRSF005384 Bacteria

SRHMM005384-1 C Proton acceptor H Proton donor 1 PIRSR005384-2 Domain

PIRSF005384 Bacteria

SRHMM005384-2 D-H D-ribulose 5-phosphate binding G-x(3)-G D-ribulose 5-phosphate binding N D-ribulose 5-phosphate R D-ribulose 5-phosphate R D-ribulose 5-phosphate R D-ribulose 5-phosphate 1 PIRSR005461-1 Domain

PIRSF005461 Archaea Eukaryota Bacteria

SRHMM005461-1 FTGRP_1 S-adenosyl-L-methionine SRHMM005461-1 K Proton acceptor 1 PIRSR005465-1 Domain

PIRSF005465 Eukaryota

SRHMM005465-1 [DEN] Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium 1 PIRSR005536-1 Domain

PIRSF005536 Eukaryota Bacteria

SRHMM005536-1 D Nucleophile D Proton donor 1 PIRSR005536-2 Domain

PIRSF005536 Eukaryota Bacteria

SRHMM005536-2 W Substrate D-D Substrate binding R Substrate K-x-D-x-N Substrate binding C Substrate D Substrate 1 PIRSR005539-1 Domain

PIRSF005539 Archaea Bacteria

SRHMM005539-1 S Nucleophile [DE] H Proton donor 1 PIRSR005557-1 Domain

PIRSF005557 Eukaryota

SRHMM005557-1 [QKR] Substrate N Substrate N Substrate [YW] Substrate Y Substrate G Substrate; via amide nitrogen G Substrate; via amide nitrogen H Substrate H Substrate 1 PIRSR005557-2 Domain

PIRSF005557 Eukaryota

SRHMM005557-2 C-x(138)-C 1 PIRSR005562-1 Domain

PIRSF005562 Eukaryota

SRHMM005562-1 S For acetyltransferase activity S For malonyltransferase activity 1 PIRSR005604-1 Domain

PIRSF005604 Eukaryota

SRHMM005604-1 E Nucleophile E Proton donor 1 PIRSR005604-2 Domain

PIRSF005604 Eukaryota

SRHMM005604-2 N-x-[ST] N-linked (GlcNAc...) asparagine 1 PIRSR005639-1 Domain

PIRSF005639 Eukaryota Bacteria Archaea

SRHMM005639-1 C Nucleophile H Charge relay system E Charge relay system 1 PIRSR005639-2 Domain

PIRSF005639 Eukaryota Bacteria Archaea

SRHMM005639-2 G-x-S L-glutamine binding R L-glutamine I-R L-glutamine binding 1 PIRSR005669-1 Domain

PIRSF005669 Eukaryota Bacteria Archaea

SRHMM005669-1 FTGRP_1 SRHMM005669-1 FTGRP_2 SRHMM005669-1 FTGRP_3 Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. SRHMM005669-1 C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM005669-1 C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM005669-1 C Iron-sulfur (4Fe-4S-S-AdoMet) 1 PIRSR005700-1 Domain

PIRSF005700 Eukaryota Bacteria

SRHMM005700-1 C H N 1 PIRSR005713-1 Domain

PIRSF005713 Eukaryota

SRHMM005713-1 FTGRP_1 SRHMM005713-1 FTGRP_2 SRHMM005713-1 FTGRP_3 SRHMM005713-1 FTGRP_4 ATP-binding Nucleotide-binding SRHMM005713-1 K ATP SRHMM005713-1 N-x-R ATP SRHMM005713-1 T ATP SRHMM005713-1 K-x-K ATP 1 PIRSR005713-2 Domain

PIRSF005713 Eukaryota

SRHMM005713-2 FTGRP_1 SRHMM005713-2 FTGRP_2 SRHMM005713-2 FTGRP_3 SRHMM005713-2 FTGRP_4 SRHMM005713-2 FTGRP_5 Disulfide bond SRHMM005713-2 C-x(9)-C SRHMM005713-2 C-x(8)-C SRHMM005713-2 C-x(45)-C SRHMM005713-2 C-x(24)-C SRHMM005713-2 C-x(20)-C 1 PIRSR005713-3 Domain

PIRSF005713 Eukaryota

SRHMM005713-3 N-x-[ST] N-linked (GlcNAc...) asparagine 1 PIRSR005739-1 Domain

PIRSF005739 Eukaryota Bacteria

SRHMM005739-1 H Proton acceptor 1 PIRSR005784-1 Domain

PIRSF005784 Bacteria

SRHMM005784-1 FTGRP_1 SRHMM005784-1 FTGRP_2 SRHMM005784-1 FTGRP_3 SRHMM005784-1 FTGRP_4 SRHMM005784-1 FTGRP_5 SRHMM005784-1 FTGRP_6 SRHMM005784-1 FTGRP_7 SRHMM005784-1 FTGRP_8 SRHMM005784-1 FTGRP_9 SRHMM005784-1 FTGRP_10 SRHMM005784-1 FTGRP_11 SRHMM005784-1 FTGRP_12 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 3 [4Fe-4S] clusters. SRHMM005784-1 C Iron-sulfur 2 (4Fe-4S) SRHMM005784-1 C Iron-sulfur 1 (4Fe-4S) SRHMM005784-1 C Iron-sulfur 1 (4Fe-4S) SRHMM005784-1 C Iron-sulfur 2 (4Fe-4S) SRHMM005784-1 C Iron-sulfur 3 (4Fe-4S) SRHMM005784-1 C Iron-sulfur 2 (4Fe-4S) SRHMM005784-1 C Iron-sulfur 1 (4Fe-4S) SRHMM005784-1 C Iron-sulfur 3 (4Fe-4S) SRHMM005784-1 C Iron-sulfur 2 (4Fe-4S) SRHMM005784-1 C Iron-sulfur 3 (4Fe-4S) SRHMM005784-1 C Iron-sulfur 3 (4Fe-4S) SRHMM005784-1 C Iron-sulfur 1 (4Fe-4S) 1 PIRSR005822-1 Domain

PIRSF005822 Eukaryota

SRHMM005822-1 FTGRP_1 Disulfide bond SRHMM005822-1 C-x(33)-C Redox-active 1 PIRSR005894-1 Domain

PIRSF005894 Eukaryota Bacteria

SRHMM005894-1 K Glutathione R Glutathione F Glutathione; via amide nitrogen and carbonyl oxygen [CSA]-[DNS] Glutathione binding 1 PIRSR005894-2 Domain

PIRSF005894 Eukaryota Bacteria

SRHMM005894-2 FTGRP_1 2Fe-2S Iron Iron-sulfur Metal-binding SRHMM005894-2 C Iron-sulfur (2Fe-2S); shared with dimeric partner 1 PIRSR005943-1 Domain

PIRSF005943 Eukaryota Bacteria

SRHMM005943-1 R Diphosphate D Nicotinamide ribonucleotide H Diphosphate R Diphosphate R-x-D Nicotinamide ribonucleotide binding G-D Nicotinamide ribonucleotide binding G Nicotinamide ribonucleotide; via amide nitrogen R Nicotinamide ribonucleotide 1 PIRSR005965-1 Domain

PIRSF005965 Bacteria

SRHMM005965-1 R Substrate R Substrate Y Substrate R Substrate 1 PIRSR005992-1 Domain

PIRSF005992 Eukaryota

SRHMM005992-1 FTGRP_1 Lipid-binding SRHMM005992-1 K Phosphatidylinositol lipid headgroup K Phosphatidylinositol lipid headgroup K Phosphatidylinositol lipid headgroup K Phosphatidylinositol lipid headgroup K Phosphatidylinositol lipid headgroup 1 PIRSR005993-1 Domain

PIRSF005993 Eukaryota

SRHMM005993-1 FTGRP_1 Disulfide bond SRHMM005993-1 C-x(20)-C 1 PIRSR006019-1 Domain

PIRSF006019 Viruses Eukaryota Bacteria

SRHMM006019-1 E Proton donor 1 PIRSR006019-2 Domain

PIRSF006019 Viruses Eukaryota Bacteria

SRHMM006019-2 FTGRP_1 SRHMM006019-2 FTGRP_2 SRHMM006019-2 FTGRP_3 Metal-binding Zinc Zn(2+) SRHMM006019-2 C Zinc; catalytic SRHMM006019-2 C Zinc; catalytic SRHMM006019-2 H Zinc; catalytic 1 PIRSR006105-1 Domain

PIRSF006105 Bacteria

SRHMM006105-1 FTGRP_1 SRHMM006105-1 FTGRP_2 SRHMM006105-1 FTGRP_3 SRHMM006105-1 FTGRP_4 Heme Binds 2 heme C groups per subunit. SRHMM006105-1 C Heme C 1; covalent SRHMM006105-1 C Heme C 1; covalent SRHMM006105-1 C Heme C 2; covalent SRHMM006105-1 C Heme C 2; covalent 1 PIRSR006105-2 Domain

PIRSF006105 Bacteria

SRHMM006105-2 FTGRP_1 SRHMM006105-2 FTGRP_2 SRHMM006105-2 FTGRP_3 SRHMM006105-2 FTGRP_4 Iron Metal-binding SRHMM006105-2 H Iron (heme C 2 axial ligand); via tele nitrogen SRHMM006105-2 H Iron (heme C 1 axial ligand); via tele nitrogen SRHMM006105-2 H Iron (heme C 1 axial ligand); via tele nitrogen SRHMM006105-2 H Iron (heme C 2 axial ligand); via tele nitrogen 1 PIRSR006113-1 Domain

PIRSF006113 Eukaryota Bacteria Archaea

SRHMM006113-1 C Proton acceptor H Charge relay system E Charge relay system 1 PIRSR006113-2 Domain

PIRSF006113 Eukaryota Bacteria Archaea

SRHMM006113-2 FTGRP_1 SRHMM006113-2 FTGRP_2 SRHMM006113-2 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM006113-2 H Zinc SRHMM006113-2 H Zinc SRHMM006113-2 H Zinc 1 PIRSR006118-1 Domain

PIRSF006118 Bacteria

SRHMM006118-1 D Substrate R Substrate R Substrate R Substrate K Substrate 1 PIRSR006118-2 Domain

PIRSF006118 Bacteria

SRHMM006118-2 FTGRP_1 SRHMM006118-2 FTGRP_2 SRHMM006118-2 FTGRP_3 Magnesium Metal-binding Mg(2+) SRHMM006118-2 D Magnesium SRHMM006118-2 D Magnesium SRHMM006118-2 D Magnesium; via carbonyl oxygen 1 PIRSR006135-1 Domain

PIRSF006135 Bacteria

SRHMM006135-1 H GMP-histidine intermediate 1 PIRSR006135-2 Domain

PIRSF006135 Bacteria

SRHMM006135-2 FTGRP_1 SRHMM006135-2 FTGRP_2 SRHMM006135-2 FTGRP_3 SRHMM006135-2 FTGRP_4 SRHMM006135-2 FTGRP_5 GTP-binding Nucleotide-binding SRHMM006135-2 A-x-[SGA] GTP SRHMM006135-2 [KR]-x(2)-R GTP SRHMM006135-2 E GTP SRHMM006135-2 G-x(6)-S GTP SRHMM006135-2 [ED] GTP; via carbonyl oxygen 1 PIRSR006156-1 Domain

PIRSF006156 Bacteria

SRHMM006156-1 H Proton donor 1 PIRSR006223-50 Domain This rule was created based on analysis for RESID:AA0269.

PIRSF006223 Bacteria

SRHMM006223-50 C Cysteine persulfide intermediate 1 PIRSR006230-1 Domain

PIRSF006230 Eukaryota Bacteria

SRHMM006230-1 FTGRP_1 SRHMM006230-1 FTGRP_2 SRHMM006230-1 FTGRP_3 SRHMM006230-1 FTGRP_4 GTP-binding Nucleotide-binding SRHMM006230-1 G GTP; via amide nitrogen SRHMM006230-1 N-S GTP SRHMM006230-1 N-x(2)-D GTP SRHMM006230-1 N-x(3)-S-[TS] GTP 1 PIRSR006241-50 Domain

PIRSF006241 Eukaryota Bacteria

SRHMM006241-50 E Proton donor/acceptor E Proton donor/acceptor 1 PIRSR006246-1 Domain

PIRSF006246 Bacteria

SRHMM006246-1 FTGRP_1 Schiff base Pyruvate pyruvate Binds 1 pyruvoyl group covalently per subunit. SRHMM006246-1 Y Proton donor SRHMM006246-1 S Schiff-base intermediate with substrate; via pyruvic acid 1 PIRSR006246-2 Domain

PIRSF006246 Bacteria

SRHMM006246-2 T Substrate G-[AGSP]-[AT] Substrate binding 1 PIRSR006246-3 Domain

PIRSF006246 Bacteria

SRHMM006246-3 FTGRP_1 Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. SRHMM006246-3 S Pyruvic acid (Ser) 1 PIRSR006246-5 Domain

PIRSF006246 Bacteria

SRHMM006246-5 G Aspartate 1-decarboxylase beta chain SRHMM006246-5 S Aspartate 1-decarboxylase alpha chain 1 PIRSR006247-1 Domain

PIRSF006247 Bacteria

SRHMM006247-1 FTGRP_1 SRHMM006247-1 FTGRP_2 SRHMM006247-1 FTGRP_3 SRHMM006247-1 FTGRP_4 SRHMM006247-1 FTGRP_5 SRHMM006247-1 FTGRP_6 SRHMM006247-1 FTGRP_7 SRHMM006247-1 FTGRP_8 Metal-binding Potassium SRHMM006247-1 [LVM] Potassium ion; via carbonyl oxygen SRHMM006247-1 [IL] Potassium ion; via carbonyl oxygen SRHMM006247-1 T Potassium ion; via carbonyl oxygen SRHMM006247-1 T Potassium ion; via carbonyl oxygen SRHMM006247-1 N Potassium ion; via carbonyl oxygen SRHMM006247-1 [AT] Potassium ion; via carbonyl oxygen SRHMM006247-1 G Potassium ion; via carbonyl oxygen SRHMM006247-1 T Potassium ion; via carbonyl oxygen 1 PIRSR006250-1 Domain

PIRSF006250 Archaea Eukaryota Bacteria

SRHMM006250-1 [RK] Substrate T-x-[KR] Substrate binding R Substrate K Substrate E Substrate D Substrate S-x-[GNS] Substrate binding [VMLIS]-x-[AFTM] Substrate binding 1 PIRSR006268-1 Domain

PIRSF006268 Bacteria

SRHMM006268-1 FTGRP_1 FAD SRHMM006268-1 M FAD; via carbonyl oxygen [YFW] FAD A-x-D FAD D FAD E FAD [IVLM] FAD; via amide nitrogen and carbonyl oxygen 1 PIRSR006268-2 Domain

PIRSF006268 Bacteria

SRHMM006268-2 FTGRP_1 SRHMM006268-2 FTGRP_2 SRHMM006268-2 FTGRP_3 Magnesium Metal-binding Mg(2+) Mn(2+) Magnesium. Can also use manganese. SRHMM006268-2 D Magnesium SRHMM006268-2 [ATSG] Magnesium; via carbonyl oxygen SRHMM006268-2 [TS] Magnesium 1 PIRSR006278-1 Domain

PIRSF006278 Eukaryota Bacteria Archaea

SRHMM006278-1 S Nucleophile 1 PIRSR006278-2 Domain

PIRSF006278 Eukaryota Bacteria Archaea

SRHMM006278-2 FTGRP_1 Pyridoxal phosphate SRHMM006278-2 K N6-(pyridoxal phosphate)lysine 1 PIRSR006325-1 Domain

PIRSF006325 Bacteria

SRHMM006325-1 FTGRP_1 SRHMM006325-1 FTGRP_2 SRHMM006325-1 FTGRP_3 SRHMM006325-1 FTGRP_4 SRHMM006325-1 FTGRP_5 S-adenosyl-L-methionine SRHMM006325-1 G-x-S S-adenosyl-L-methionine binding SRHMM006325-1 N S-adenosyl-L-methionine SRHMM006325-1 D-I S-adenosyl-L-methionine binding SRHMM006325-1 Y S-adenosyl-L-methionine SRHMM006325-1 D-N S-adenosyl-L-methionine binding 1 PIRSR006336-1 Domain

PIRSF006336 Eukaryota Bacteria

SRHMM006336-1 E Proton donor E Nucleophile 1 PIRSR006337-1 Domain

PIRSF006337 Archaea Bacteria

SRHMM006337-1 FTGRP_1 Cytoplasm SRHMM006337-1 D Nucleophile E Proton donor 1 PIRSR006337-2 Domain

PIRSF006337 Bacteria Archaea

SRHMM006337-2 R-x(4)-H Substrate binding D-x(3)-H Substrate binding H-x(4)-N Substrate binding 1 PIRSR006337-3 Domain

PIRSF006337 Archaea Bacteria

SRHMM006337-3 D Transition state stabilizer 1 PIRSR006356-1 Domain

PIRSF006356 Bacteria

SRHMM006356-1 C Amidino-cysteine intermediate 1 PIRSR006386-1 Domain

PIRSF006386 Eukaryota Bacteria

SRHMM006386-1 S Nucleophile 1 PIRSR006386-2 Domain

PIRSF006386 Eukaryota Bacteria

SRHMM006386-2 S Glutathione K Substrate N-R Substrate binding Y Substrate [VL] Glutathione; via amide nitrogen and carbonyl oxygen W-x(2)-D Glutathione binding 1 PIRSR006404-1 Domain

PIRSF006404 Bacteria Archaea

SRHMM006404-1 E 1 PIRSR006404-2 Domain

PIRSF006404 Bacteria Archaea

SRHMM006404-2 FTGRP_1 SRHMM006404-2 FTGRP_2 SRHMM006404-2 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM006404-2 H Zinc; catalytic SRHMM006404-2 D Zinc; catalytic SRHMM006404-2 H Zinc; catalytic 1 PIRSR006429-1 Domain

PIRSF006429 Bacteria Archaea

SRHMM006429-1 FTGRP_1 SRHMM006429-1 FTGRP_2 SRHMM006429-1 FTGRP_3 SRHMM006429-1 FTGRP_4 SRHMM006429-1 FTGRP_5 SRHMM006429-1 FTGRP_6 SRHMM006429-1 FTGRP_7 SRHMM006429-1 FTGRP_8 4Fe-4S Iron Iron-sulfur Metal-binding SRHMM006429-1 C Iron-sulfur 1 (4Fe-4S) SRHMM006429-1 C Iron-sulfur 2 (4Fe-4S) SRHMM006429-1 C Iron-sulfur 1 (4Fe-4S) SRHMM006429-1 C Iron-sulfur 2 (4Fe-4S) SRHMM006429-1 C Iron-sulfur 1 (4Fe-4S) SRHMM006429-1 C Iron-sulfur 2 (4Fe-4S) SRHMM006429-1 C Iron-sulfur 1 (4Fe-4S) SRHMM006429-1 C Iron-sulfur 2 (4Fe-4S) 1 PIRSR006431-1 Domain

PIRSF006431 Eukaryota Bacteria

SRHMM006431-1 S Nucleophile D H Proton donor 1 PIRSR006439-50 Domain This rule was created based on analysis for RESID:AA0140.

PIRSF006439 Bacteria Archaea

SRHMM006439-50 FTGRP_1 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP. SRHMM006439-50 C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) 1 PIRSR006468-1 Domain

PIRSF006468 Eukaryota Bacteria

SRHMM006468-1 K N6-(pyridoxal phosphate)lysine 1 PIRSR006470-1 Domain

PIRSF006470 Eukaryota Bacteria Archaea

SRHMM006470-1 E Sialic acid [RK] Sialic acid [RK] Sialic acid N Sialic acid 1 PIRSR006614-1 Domain

PIRSF006614 Bacteria

SRHMM006614-1 D Proton donor/acceptor 1 PIRSR006615-1 Domain

PIRSF006615 Bacteria Archaea

SRHMM006615-1 FTGRP_1 SRHMM006615-1 FTGRP_2 SRHMM006615-1 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM006615-1 H Zinc; catalytic SRHMM006615-1 E Zinc; catalytic SRHMM006615-1 H Zinc; catalytic 1 PIRSR006615-2 Domain

PIRSF006615 Eukaryota Bacteria Archaea

SRHMM006615-2 E Proton donor/acceptor 1 PIRSR006621-1 Domain

PIRSF006621 Eukaryota Bacteria

SRHMM006621-1 C Proton donor 1 PIRSR006661-1 Domain

PIRSF006661 Bacteria

SRHMM006661-1 C Nucleophile and sulfur donor 1 PIRSR006698-2 Domain

PIRSF006698 Eukaryota

SRHMM006698-2 FTGRP_1 GTP-binding Nucleotide-binding SRHMM006698-2 F Important for dimerization 1 PIRSR006769-1 Domain

PIRSF006769 Bacteria

SRHMM006769-1 E Proton donor 1 PIRSR006769-2 Domain

PIRSF006769 Bacteria

SRHMM006769-2 FTGRP_1 SRHMM006769-2 FTGRP_3 SRHMM006769-2 FTGRP_5 SRHMM006769-2 FTGRP_6 SRHMM006769-2 FTGRP_9 SRHMM006769-2 FTGRP_11 NADP SRHMM006769-2 S Substrate SRHMM006769-2 E Substrate SRHMM006769-2 [AG] NADP; via amide nitrogen and carbonyl oxygen SRHMM006769-2 G-x(5)-[SAG] NADP SRHMM006769-2 D NADP SRHMM006769-2 T NADP SRHMM006769-2 [TS] NADP SRHMM006769-2 R Substrate SRHMM006769-2 L Substrate; via amide nitrogen SRHMM006769-2 R Substrate SRHMM006769-2 W NADP 1 PIRSR006769-3 Domain

PIRSF006769 Bacteria

SRHMM006769-3 FTGRP_1 SRHMM006769-3 FTGRP_2 SRHMM006769-3 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion. SRHMM006769-3 H Zinc; catalytic SRHMM006769-3 C Zinc; catalytic SRHMM006769-3 C Zinc; catalytic 1 PIRSR006779-1 Domain

PIRSF006779 Bacteria Archaea

SRHMM006779-1 D Substrate Y-x-Y Substrate binding T-x(2)-G Substrate binding 1 PIRSR006806-1 Domain

PIRSF006806 Eukaryota Bacteria

SRHMM006806-1 FTGRP_1 SRHMM006806-1 FTGRP_4 ATP-binding Nucleotide-binding SRHMM006806-1 [LIVME] Substrate; via carbonyl oxygen SRHMM006806-1 R-x-G-x(5)-Y ATP SRHMM006806-1 [KR]-x(3)-R ATP SRHMM006806-1 E Substrate 1 PIRSR006809-1 Domain

PIRSF006809 Eukaryota Bacteria Archaea

SRHMM006809-1 FTGRP_1 SRHMM006809-1 FTGRP_2 SRHMM006809-1 FTGRP_3 SRHMM006809-1 FTGRP_4 SRHMM006809-1 FTGRP_5 GTP-binding Nucleotide-binding SRHMM006809-1 N-x(2)-D GTP SRHMM006809-1 F-x(3)-[STD] GTP SRHMM006809-1 S-x-[LQKRHYT] GTP SRHMM006809-1 G-x(6)-[TS] GTP SRHMM006809-1 D-x(2)-G GTP 1 PIRSR006809-2 Domain

PIRSF006809 Eukaryota Bacteria Archaea

SRHMM006809-2 FTGRP_1 SRHMM006809-2 FTGRP_2 Magnesium Metal-binding Mg(2+) SRHMM006809-2 T Magnesium SRHMM006809-2 [TS] Magnesium 1 PIRSR006816-1 Domain

PIRSF006816 Archaea Bacteria

SRHMM006816-1 FTGRP_1 SRHMM006816-1 FTGRP_2 SRHMM006816-1 FTGRP_3 FAD Flavoprotein FAD Binds 1 FAD per subunit. SRHMM006816-1 G-T FAD SRHMM006816-1 [LIV]-x-[RQ] FAD SRHMM006816-1 R-x(2)-S FAD 1 PIRSR006816-2 Domain

PIRSF006816 Archaea Bacteria

SRHMM006816-2 FTGRP_1 SRHMM006816-2 FTGRP_2 SRHMM006816-2 FTGRP_3 SRHMM006816-2 FTGRP_4 2Fe-2S Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster per subunit. SRHMM006816-2 C Iron-sulfur (2Fe-2S) SRHMM006816-2 C Iron-sulfur (2Fe-2S) SRHMM006816-2 C Iron-sulfur (2Fe-2S) SRHMM006816-2 C Iron-sulfur (2Fe-2S) 1 PIRSR007531-1 Domain

PIRSF007531 Bacteria

SRHMM007531-1 D 1 PIRSR007531-2 Domain

PIRSF007531 Bacteria

SRHMM007531-2 G-x(6)-[ST] ATP 1 PIRSR007802-1 Domain

PIRSF007802 Eukaryota

SRHMM007802-1 C Glycyl thioester intermediate 1 PIRSR007828-1 Domain

PIRSF007828 Eukaryota

SRHMM007828-1 E 1 PIRSR007828-2 Domain

PIRSF007828 Eukaryota

SRHMM007828-2 FTGRP_1 SRHMM007828-2 FTGRP_2 SRHMM007828-2 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM007828-2 H Zinc; catalytic SRHMM007828-2 E Zinc; catalytic SRHMM007828-2 H Zinc; catalytic 1 PIRSR008129-1 Domain

PIRSF008129 Eukaryota

SRHMM008129-1 FTGRP_1 SRHMM008129-1 FTGRP_2 SRHMM008129-1 FTGRP_3 SRHMM008129-1 FTGRP_4 Disulfide bond SRHMM008129-1 C-x(45)-C SRHMM008129-1 C-x(7)-C SRHMM008129-1 C-x(36)-C SRHMM008129-1 C-x(49)-C 1 PIRSR008129-2 Domain

PIRSF008129 Eukaryota

SRHMM008129-2 N-x-[ST] N-linked (GlcNAc...) asparagine 1 PIRSR008716-1 Domain

PIRSF008716 Eukaryota

SRHMM008716-1 C Glycyl thioester intermediate 1 PIRSR009103-1 Domain

PIRSF009103 Bacteria

SRHMM009103-1 H Important for lysozyme inhibition 1 PIRSR009103-2 Domain

PIRSF009103 Bacteria

SRHMM009103-2 FTGRP_1 Disulfide bond SRHMM009103-2 C-x(4)-C 1 PIRSR009283-1 Domain

PIRSF009283 Eukaryota Bacteria

SRHMM009283-1 FTGRP_1 Metal-binding Iron Fe cation Binds 1 Fe cation per subunit. SRHMM009283-1 H Iron H Iron E Iron 1 PIRSR009285-1 Domain

PIRSF009285 Eukaryota

SRHMM009285-1 FTGRP_1 SRHMM009285-1 FTGRP_4 SRHMM009285-1 FTGRP_5 SRHMM009285-1 FTGRP_6 SRHMM009285-1 FTGRP_7 S-adenosyl-L-methionine SRHMM009285-1 W-E S-adenosyl-L-methionine binding SRHMM009285-1 W S-adenosyl-L-methionine SRHMM009285-1 E-x-N S-adenosyl-L-methionine binding SRHMM009285-1 M S-adenosyl-L-methionine SRHMM009285-1 F-G-M-x-I-A S-adenosyl-L-methionine binding SRHMM009285-1 L-T Substrate binding SRHMM009285-1 E Substrate SRHMM009285-1 M Substrate 1 PIRSR009328-1 Domain

PIRSF009328 Eukaryota

SRHMM009328-1 FTGRP_1 SRHMM009328-1 FTGRP_2 SRHMM009328-1 FTGRP_6 S-adenosyl-L-methionine SRHMM009328-1 [YHW] Substrate SRHMM009328-1 R Substrate; via carbonyl oxygen SRHMM009328-1 E-x-L S-adenosyl-L-methionine binding SRHMM009328-1 N-H S-adenosyl-L-methionine binding SRHMM009328-1 D Substrate; via carbonyl oxygen SRHMM009328-1 Y Substrate SRHMM009328-1 R Substrate SRHMM009328-1 Y Substrate SRHMM009328-1 R S-adenosyl-L-methionine 1 PIRSR009343-1 Domain

PIRSF009343 Eukaryota

SRHMM009343-1 FTGRP_1 S-adenosyl-L-methionine SRHMM009343-1 R-x-W S-adenosyl-L-methionine binding N-H S-adenosyl-L-methionine binding Y S-adenosyl-L-methionine K S-adenosyl-L-methionine; via amide nitrogen 1 PIRSR009343-2 Domain

PIRSF009343 Eukaryota

SRHMM009343-2 FTGRP_1 SRHMM009343-2 FTGRP_2 SRHMM009343-2 FTGRP_3 SRHMM009343-2 FTGRP_4 SRHMM009343-2 FTGRP_5 SRHMM009343-2 FTGRP_6 SRHMM009343-2 FTGRP_7 SRHMM009343-2 FTGRP_8 SRHMM009343-2 FTGRP_9 SRHMM009343-2 FTGRP_10 SRHMM009343-2 FTGRP_11 SRHMM009343-2 FTGRP_12 SRHMM009343-2 FTGRP_13 Metal-binding Zinc SRHMM009343-2 C Zinc 1 SRHMM009343-2 C Zinc 4 SRHMM009343-2 C Zinc 2 C Zinc 3 SRHMM009343-2 C Zinc 4 SRHMM009343-2 C Zinc 3 SRHMM009343-2 C Zinc 1 C Zinc 3 SRHMM009343-2 C Zinc 2 SRHMM009343-2 C Zinc 2 SRHMM009343-2 C Zinc 4 SRHMM009343-2 C Zinc 1 C Zinc 2 SRHMM009343-2 C Zinc 4 SRHMM009343-2 C Zinc 1 SRHMM009343-2 C Zinc 3 1 PIRSR009374-1 Domain

PIRSF009374 Eukaryota

SRHMM009374-1 N Chloride 1 E Chloride 1; via amide nitrogen R Chloride 2 V Chloride 2; via amide nitrogen 1 PIRSR009393-1 Domain

PIRSF009393 Bacteria

SRHMM009393-1 FTGRP_1 Pyridoxal phosphate SRHMM009393-1 K N6-(pyridoxal phosphate)lysine 1 PIRSR009400-1 Domain

PIRSF009400 Eukaryota

SRHMM009400-1 G-C Cleavage; by autolysis D Involved in cholesterol transfer T Involved in auto-cleavage H Essential for auto-cleavage 1 PIRSR009400-2 Domain

PIRSF009400 Eukaryota

SRHMM009400-2 FTGRP_8 SRHMM009400-2 FTGRP_9 SRHMM009400-2 FTGRP_10 Zinc SRHMM009400-2 FTGRP_1 SRHMM009400-2 FTGRP_2 SRHMM009400-2 FTGRP_3 SRHMM009400-2 FTGRP_4 SRHMM009400-2 FTGRP_5 SRHMM009400-2 FTGRP_6 SRHMM009400-2 FTGRP_7 Calcium SRHMM009400-2 FTGRP_1 SRHMM009400-2 FTGRP_2 SRHMM009400-2 FTGRP_3 SRHMM009400-2 FTGRP_4 SRHMM009400-2 FTGRP_5 SRHMM009400-2 FTGRP_6 SRHMM009400-2 FTGRP_7 SRHMM009400-2 FTGRP_8 SRHMM009400-2 FTGRP_9 SRHMM009400-2 FTGRP_10 Metal-binding SRHMM009400-2 T Calcium 1; via carbonyl oxygen SRHMM009400-2 E Calcium 1 E Calcium 2 SRHMM009400-2 H Zinc SRHMM009400-2 H Zinc SRHMM009400-2 D Zinc SRHMM009400-2 E Calcium 1 E Calcium 2 SRHMM009400-2 D Calcium 1 SRHMM009400-2 E Calcium 1 SRHMM009400-2 D Calcium 2 SRHMM009400-2 D Calcium 2 1 PIRSR009407-1 Domain

PIRSF009407 Bacteria

SRHMM009407-1 K Critical for catalysis Y Critical for catalysis 1 PIRSR009407-2 Domain

PIRSF009407 Bacteria

SRHMM009407-2 S-x(2)-N-x(3)-R Substrate binding R Substrate R Substrate 1 PIRSR009407-3 Domain

PIRSF009407 Bacteria

SRHMM009407-3 FTGRP_1 Magnesium Metal-binding Mg(2+) Mn(2+) Binds 1 Mg(2+) or Mn(2+) ion per subunit. SRHMM009407-3 D Magnesium or manganese D Magnesium or manganese D Magnesium or manganese 1 PIRSR009407-4 Domain

PIRSF009407 Bacteria

SRHMM009407-4 FTGRP_1 NADP SRHMM009407-4 K-x(4)-S NADP N NADP G-S NADP H NADP R-x-D NADP R NADP 1 PIRSR009449-1 Domain

PIRSF009449 Eukaryota

SRHMM009449-1 FTGRP_1 SRHMM009449-1 FTGRP_2 SRHMM009449-1 FTGRP_3 SRHMM009449-1 FTGRP_4 4Fe-4S Iron Iron-sulfur Metal-binding SRHMM009449-1 C Iron-sulfur (4Fe-4S) SRHMM009449-1 C Iron-sulfur (4Fe-4S) SRHMM009449-1 C Iron-sulfur (4Fe-4S) SRHMM009449-1 C Iron-sulfur (4Fe-4S) 1 PIRSR010354-50 Domain

PIRSF010354 Metazoa

SRHMM010354-50 FTGRP_1 SRHMM010354-50 FTGRP_2 SRHMM010354-50 FTGRP_3 SRHMM010354-50 FTGRP_4 SRHMM010354-50 FTGRP_5 S-adenosyl-L-methionine SRHMM010354-50 H S-adenosyl-L-methionine SRHMM010354-50 Y S-adenosyl-L-methionine SRHMM010354-50 N S-adenosyl-L-methionine SRHMM010354-50 R S-adenosyl-L-methionine SRHMM010354-50 N-H S-adenosyl-L-methionine binding 1 PIRSR010354-51 Domain

PIRSF010354 Metazoa

SRHMM010354-51 FTGRP_1 Zinc Metal-binding SRHMM010354-51 C Zinc C Zinc C Zinc C Zinc 1 PIRSR011356-1 Domain

PIRSF011356 Viruses

SRHMM011356-1 FTGRP_1 Metal-binding Zinc Zinc-finger SRHMM011356-1 C-x(8)-C-x(4)-C-x(3)-H C3H1-type; atypical 1 PIRSR011396-1 Domain

PIRSF011396 Bacteria

SRHMM011396-1 K 1 PIRSR011396-2 Domain

PIRSF011396 Bacteria

SRHMM011396-2 FTGRP_1 SRHMM011396-2 FTGRP_3 SRHMM011396-2 FTGRP_4 SRHMM011396-2 FTGRP_6 FAD Nucleotide-binding SRHMM011396-2 E L-tryptophan; via carbonyl oxygen SRHMM011396-2 K L-tryptophan SRHMM011396-2 L FAD; via amide nitrogen SRHMM011396-2 V FAD; via amide nitrogen and carbonyl oxygen SRHMM011396-2 G-x(2)-A FAD SRHMM011396-2 I FAD; via amide nitrogen 1 PIRSR011502-1 Domain

PIRSF011502 Bacteria

SRHMM011502-1 FTGRP_1 SRHMM011502-1 FTGRP_2 SRHMM011502-1 FTGRP_3 Magnesium Metal-binding SRHMM011502-1 D Magnesium SRHMM011502-1 D Magnesium SRHMM011502-1 T Magnesium 1 PIRSR011502-2 Domain

PIRSF011502 Bacteria

SRHMM011502-2 FTGRP_1 SRHMM011502-2 FTGRP_2 SRHMM011502-2 FTGRP_3 SRHMM011502-2 FTGRP_4 ATP-binding Nucleotide-binding SRHMM011502-2 G-S ATP SRHMM011502-2 R ATP SRHMM011502-2 N-x-[ST] ATP SRHMM011502-2 E-x(2)-K ATP 1 PIRSR011588-50 Domain

PIRSF011588 Bacteria

SRHMM011588-50 FTGRP_1 Schiff base SRHMM011588-50 C Schiff-base intermediate with substrate; via pyruvic acid 1 PIRSR011588-51 Domain This rule was created based on analysis for RESID:AA0127.

PIRSF011588 Bacteria

SRHMM011588-51 FTGRP_1 Pyruvate SRHMM011588-51 C Pyruvic acid (Cys) 1 PIRSR011789-1 Domain

PIRSF011789 Eukaryota

SRHMM011789-1 Y H K 1 PIRSR011794-1 Domain

PIRSF011794 Fungi

SRHMM011794-1 FTGRP_1 Disulfide bond SRHMM011794-1 C-x(42)-C C-x(8)-C 1 PIRSR011861-1 Domain

PIRSF011861 Eukaryota

SRHMM011861-1 E Proton acceptor K Proton donor C Nucleophile 1 PIRSR012565-1 Domain

PIRSF012565 Firmicutes

SRHMM012565-1 FTGRP_1 Disulfide bond SRHMM012565-1 C-x(3)-C 1 PIRSR013503-1 Domain

PIRSF013503 Eukaryota

SRHMM013503-1 D C Nucleophile H 1 PIRSR013503-2 Domain

PIRSF013503 Eukaryota

SRHMM013503-2 Y Interacts with free ubiquitin SRHMM013503-2 I Interacts with free ubiquitin SRHMM013503-2 D Interacts with free ubiquitin SRHMM013503-2 Y Interacts with free ubiquitin SRHMM013503-2 Y Interacts with free ubiquitin 1 PIRSR014972-1 Domain

PIRSF014972 Bacteria

SRHMM014972-1 T E H 1 PIRSR014972-2 Domain

PIRSF014972 Bacteria

SRHMM014972-2 G Coenzyme A; via carbonyl oxygen G Substrate; via amide nitrogen and carbonyl oxygen R Substrate 1 PIRSR015244-50 Domain

PIRSF015244 Bacteria

SRHMM015244-50 FTGRP_1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM015244-50 H Zinc; via tele nitrogen D Zinc H Zinc; via tele nitrogen 1 PIRSR015477-1 Domain

PIRSF015477 Bacteria

SRHMM015477-1 D Charge relay system H Charge relay system S Charge relay system 1 PIRSR015582-1 Domain

PIRSF015582 Eukaryota Bacteria

SRHMM015582-1 R Substrate E Substrate 1 PIRSR015582-2 Domain

PIRSF015582 Eukaryota Bacteria

SRHMM015582-2 FTGRP_1 SRHMM015582-2 FTGRP_2 Magnesium Metal-binding SRHMM015582-2 E Magnesium SRHMM015582-2 D Magnesium 1 PIRSR015599-1 Domain

PIRSF015599 Eukaryota

SRHMM015599-1 FTGRP_1 SRHMM015599-1 FTGRP_2 Disulfide bond SRHMM015599-1 C-x(84)-C SRHMM015599-1 C-x(94)-C 1 PIRSR015604-1 Domain

PIRSF015604 Eukaryota

SRHMM015604-1 FTGRP_1 SRHMM015604-1 FTGRP_2 SRHMM015604-1 FTGRP_3 Disulfide bond SRHMM015604-1 C-x(19)-C SRHMM015604-1 C-x(34)-C SRHMM015604-1 C-x(57)-C 1 PIRSR015693-50 Domain

PIRSF015693 Viruses

SRHMM015693-50 D D 1 PIRSR015753-1 Domain

PIRSF015753 Eukaryota Bacteria Archaea

SRHMM015753-1 C Nucleophile Y Proton donor/acceptor 1 PIRSR015852-1 Domain

PIRSF015852 Bacteria

SRHMM015852-1 FTGRP_1 SRHMM015852-1 FTGRP_2 SRHMM015852-1 FTGRP_3 SRHMM015852-1 FTGRP_4 SRHMM015852-1 FTGRP_5 SRHMM015852-1 FTGRP_6 S-adenosyl-L-methionine SRHMM015852-1 D-[LVI] S-adenosyl-L-methionine binding SRHMM015852-1 H-x(5)-R S-adenosyl-L-methionine binding SRHMM015852-1 L S-adenosyl-L-methionine; via carbonyl oxygen SRHMM015852-1 Q S-adenosyl-L-methionine SRHMM015852-1 D S-adenosyl-L-methionine SRHMM015852-1 [AG] S-adenosyl-L-methionine; via carbonyl oxygen 1 PIRSR015853-1 Domain

PIRSF015853 Bacteria

SRHMM015853-1 H Nucleophile 1 PIRSR015853-2 Domain

PIRSF015853 Bacteria

SRHMM015853-2 FTGRP_1 SRHMM015853-2 FTGRP_2 SRHMM015853-2 FTGRP_3 SRHMM015853-2 FTGRP_4 SRHMM015853-2 FTGRP_5 Metal-binding Zinc SRHMM015853-2 H Zinc 2 SRHMM015853-2 D Zinc 1 D Zinc 2 SRHMM015853-2 H Zinc 2 SRHMM015853-2 E Zinc 1 SRHMM015853-2 E Zinc 2 1 PIRSR015894-1 Domain

PIRSF015894 Eukaryota

SRHMM015894-1 E Proton donor/acceptor E Proton donor/acceptor 1 PIRSR015894-2 Domain

PIRSF015894 Eukaryota

SRHMM015894-2 FTGRP_1 SRHMM015894-2 FTGRP_2 SRHMM015894-2 FTGRP_3 SRHMM015894-2 FTGRP_4 S-adenosyl-L-methionine SRHMM015894-2 D-M S-adenosyl-L-methionine binding SRHMM015894-2 K-Y S-adenosyl-L-methionine binding SRHMM015894-2 Y S-adenosyl-L-methionine SRHMM015894-2 E S-adenosyl-L-methionine 1 PIRSR015894-3 Domain

PIRSF015894 Eukaryota

SRHMM015894-3 F Critical for specifying symmetric addition of methyl groups 1 PIRSR015919-1 Domain

PIRSF015919 Eukaryota

SRHMM015919-1 C-x(2)-C-x(4)-C-x(8)-C C4-type 1 PIRSR015957-1 Domain

PIRSF015957 Bacteria Archaea

SRHMM015957-1 K Schiff-base intermediate with substrate K Proton acceptor 1 PIRSR016020-1 Domain

PIRSF016020 Eukaryota Bacteria

SRHMM016020-1 H E 1 PIRSR016020-2 Domain

PIRSF016020 Eukaryota Bacteria

SRHMM016020-2 R Substrate Q Substrate R Substrate 1 PIRSR016055-50 Domain This rule was created based on analysis for RESID:AA0349.

PIRSF016055 Bacteria

SRHMM016055-50 FTGRP_1 Flavoprotein FMN Phosphoprotein FMN SRHMM016055-50 T FMN phosphoryl threonine 1 PIRSR016150-50 Domain

PIRSF016150 Helicobacter

SRHMM016150-50 G Substrate; via carbonyl oxygen V-x(2)-N Substrate binding R Substrate [VI]-x(2)-K Substrate binding N Substrate Y-x(3)-K Substrate binding 1 PIRSR016150-51 Domain

PIRSF016150 Helicobacter

SRHMM016150-51 E Important for catalytic activity 1 PIRSR016184-1 Domain

PIRSF016184 Eukaryota Bacteria

SRHMM016184-1 E 1 PIRSR016238-1 Domain

PIRSF016238 Eukaryota

SRHMM016238-1 FTGRP_1 SRHMM016238-1 FTGRP_2 SRHMM016238-1 FTGRP_3 SRHMM016238-1 FTGRP_4 Disulfide bond SRHMM016238-1 C-x(60)-C SRHMM016238-1 C-x(62)-C SRHMM016238-1 C Interchain SRHMM016238-1 C-x(60)-C 1 PIRSR016262-1 Domain

PIRSF016262 Eukaryota Bacteria Archaea

SRHMM016262-1 C Acyl-thioester intermediate 1 PIRSR016262-2 Domain

PIRSF016262 Eukaryota Bacteria Archaea

SRHMM016262-2 R-x(6)-H Substrate binding [AS]-x-[GA] Substrate binding G-x-[ASG] Substrate binding 1 PIRSR016262-3 Domain

PIRSF016262 Eukaryota Bacteria Archaea

SRHMM016262-3 K Lowers pKa of active site Cys 1 PIRSR016305-1 Domain

PIRSF016305 Eukaryota

SRHMM016305-1 FTGRP_1 SRHMM016305-1 FTGRP_2 SRHMM016305-1 FTGRP_3 SRHMM016305-1 FTGRP_4 S-adenosyl-L-methionine SRHMM016305-1 G S-adenosyl-L-methionine; via carbonyl oxygen SRHMM016305-1 E S-adenosyl-L-methionine; via carbonyl oxygen SRHMM016305-1 R S-adenosyl-L-methionine SRHMM016305-1 [DN]-[LIVF] S-adenosyl-L-methionine binding 1 PIRSR016308-1 Domain

PIRSF016308 Eukaryota

SRHMM016308-1 C Nucleophile H Proton acceptor 1 PIRSR016308-2 Domain

PIRSF016308 Eukaryota

SRHMM016308-2 W Substrate R-x(2)-F Substrate binding Y Substrate Y Substrate; via carbonyl oxygen D Substrate 1 PIRSR016308-3 Domain

PIRSF016308 Eukaryota

SRHMM016308-3 FTGRP_1 SRHMM016308-3 FTGRP_2 SRHMM016308-3 FTGRP_3 SRHMM016308-3 FTGRP_4 Metal-binding Zinc SRHMM016308-3 H Zinc SRHMM016308-3 C Zinc SRHMM016308-3 C Zinc SRHMM016308-3 C Zinc 1 PIRSR016308-4 Domain

PIRSF016308 Eukaryota

SRHMM016308-4 FTGRP_1 Disulfide bond SRHMM016308-4 C-x(620)-C 1 PIRSR016323-1 Domain

PIRSF016323 Eukaryota

SRHMM016323-1 D Proton acceptor 1 PIRSR016323-2 Domain

PIRSF016323 Eukaryota

SRHMM016323-2 L S-adenosyl-L-methionine; via carbonyl oxygen G S-adenosyl-L-methionine; via amide nitrogen C S-adenosyl-L-methionine; via amide nitrogen L S-adenosyl-L-methionine; via amide nitrogen 1 PIRSR016408-1 Domain

PIRSF016408 Eukaryota

SRHMM016408-1 S Phosphoserine intermediate 1 PIRSR016408-2 Domain

PIRSF016408 Eukaryota

SRHMM016408-2 E-x-N Substrate binding R-x(3)-T Substrate binding R Substrate 1 PIRSR016408-3 Domain

PIRSF016408 Eukaryota

SRHMM016408-3 FTGRP_1 SRHMM016408-3 FTGRP_2 SRHMM016408-3 FTGRP_3 SRHMM016408-3 FTGRP_4 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM016408-3 D Magnesium SRHMM016408-3 D Magnesium SRHMM016408-3 S Magnesium; via phosphate group SRHMM016408-3 D Magnesium 1 PIRSR016429-50 Domain

PIRSF016429 Eukaryota

SRHMM016429-50 R Required for activity R Required for activity 1 PIRSR016429-51 Domain This rule was created based on analysis for RESID:AA0327.

PIRSF016429 Eukaryota

SRHMM016429-51 FTGRP_1 Glycoprotein SRHMM016429-51 R N-linked (Glc...) arginine 1 PIRSR016487-1 Domain

PIRSF016487 Bacteria

SRHMM016487-1 Y Proton acceptor 1 PIRSR016496-1 Domain

PIRSF016496 Archaea Eukaryota Bacteria

SRHMM016496-1 FTGRP_1 SRHMM016496-1 FTGRP_3 SRHMM016496-1 FTGRP_6 SRHMM016496-1 FTGRP_7 SRHMM016496-1 FTGRP_8 SRHMM016496-1 FTGRP_9 ATP-binding Nucleotide-binding SRHMM016496-1 K ATP SRHMM016496-1 D ATP SRHMM016496-1 [GAST] Substrate; via amide nitrogen SRHMM016496-1 H Substrate SRHMM016496-1 Y-x(4)-K ATP SRHMM016496-1 [GAST] ATP; via carbonyl oxygen SRHMM016496-1 [GAST] Substrate; via amide nitrogen SRHMM016496-1 K-x(3)-S ATP SRHMM016496-1 [GAST] ATP; via amide nitrogen 1 PIRSR016496-2 Domain

PIRSF016496 Archaea Eukaryota Bacteria

SRHMM016496-2 K Transition state stabilizer 1 PIRSR016502-1 Domain

PIRSF016502 Eukaryota Bacteria

SRHMM016502-1 T Important for channel permeability 1 PIRSR016521-1 Domain

PIRSF016521 Eukaryota Bacteria Archaea

SRHMM016521-1 [SC] Charge relay system D Charge relay system H Charge relay system 1 PIRSR016527-1 Domain

PIRSF016527 Eukaryota

SRHMM016527-1 [EA]-M Cleavage 1 PIRSR016527-2 Domain

PIRSF016527 Eukaryota

SRHMM016527-2 FTGRP_1 Disulfide bond SRHMM016527-2 C-x(39)-C 1 PIRSR016567-50 Domain

PIRSF016567 Vertebrata

SRHMM016567-50 FTGRP_1 Disulfide bond SRHMM016567-50 C-x(7)-C C-x(20)-C C-x(7)-C C-x(22)-C 1 PIRSR016567-52 Domain

PIRSF016567 Vertebrata

SRHMM016567-52 FTGRP_1 Lipoprotein Palmitate SRHMM016567-52 C S-palmitoyl cysteine 1 PIRSR016573-1 Domain

PIRSF016573 Bacteria

SRHMM016573-1 E 1 PIRSR016573-2 Domain

PIRSF016573 Bacteria

SRHMM016573-2 FTGRP_1 SRHMM016573-2 FTGRP_2 Calcium Metal-binding Ca(2+) Binds 1 Ca(2+) ion per subunit. SRHMM016573-2 FTGRP_3 SRHMM016573-2 FTGRP_4 SRHMM016573-2 FTGRP_5 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM016573-2 H Zinc; catalytic SRHMM016573-2 D Zinc; catalytic SRHMM016573-2 T Calcium SRHMM016573-2 H Zinc; catalytic SRHMM016573-2 D Calcium 1 PIRSR016573-3 Domain

PIRSF016573 Bacteria

SRHMM016573-3 C-x(12)-C 1 PIRSR016616-1 Domain

PIRSF016616 Bacteria Eukaryota

SRHMM016616-1 FTGRP_1 S-adenosyl-L-methionine SRHMM016616-1 G S-adenosyl-L-methionine; via carbonyl oxygen E S-adenosyl-L-methionine Q S-adenosyl-L-methionine S S-adenosyl-L-methionine; via amide nitrogen I S-adenosyl-L-methionine; via carbonyl oxygen 1 PIRSR016616-2 Domain

PIRSF016616 Bacteria Eukaryota

SRHMM016616-2 E Substrate N Substrate 1 PIRSR016958-1 Domain

PIRSF016958 Eukaryota

SRHMM016958-1 FTGRP_1 SRHMM016958-1 FTGRP_2 SRHMM016958-1 FTGRP_3 SRHMM016958-1 FTGRP_4 SRHMM016958-1 FTGRP_5 S-adenosyl-L-methionine SRHMM016958-1 [DE]-x-T S-adenosyl-L-methionine binding SRHMM016958-1 Q S-adenosyl-L-methionine; via carbonyl oxygen SRHMM016958-1 G S-adenosyl-L-methionine; via carbonyl oxygen SRHMM016958-1 [LMVI]-Q S-adenosyl-L-methionine binding SRHMM016958-1 R S-adenosyl-L-methionine 1 PIRSR017107-1 Domain

PIRSF017107 Eukaryota Bacteria Archaea

SRHMM017107-1 K Proton acceptor 1 PIRSR017107-2 Domain

PIRSF017107 Eukaryota Bacteria Archaea

SRHMM017107-2 Q L-threo-beta-methylaspartate Q L-threo-beta-methylaspartate 1 PIRSR017107-3 Domain

PIRSF017107 Eukaryota Bacteria Archaea

SRHMM017107-3 H Transition state stabilizer 1 PIRSR017107-4 Domain

PIRSF017107 Eukaryota Bacteria Archaea

SRHMM017107-4 FTGRP_1 SRHMM017107-4 FTGRP_2 SRHMM017107-4 FTGRP_3 Magnesium Metal-binding Mg(2+) SRHMM017107-4 D Magnesium SRHMM017107-4 D Magnesium SRHMM017107-4 E Magnesium 1 PIRSR017199-1 Domain

PIRSF017199 Eukaryota

SRHMM017199-1 C-x(40)-C 1 PIRSR017205-1 Domain

PIRSF017205 Eukaryota

SRHMM017205-1 C Nucleophile C 1 PIRSR017205-2 Domain

PIRSF017205 Eukaryota

SRHMM017205-2 FTGRP_1 SRHMM017205-2 FTGRP_2 SRHMM017205-2 FTGRP_3 SRHMM017205-2 FTGRP_4 SRHMM017205-2 FTGRP_5 SRHMM017205-2 FTGRP_6 FAD FAD SRHMM017205-2 [RK] FAD SRHMM017205-2 R FAD SRHMM017205-2 H FAD SRHMM017205-2 S FAD SRHMM017205-2 W FAD SRHMM017205-2 T FAD 1 PIRSR017205-3 Domain

PIRSF017205 Eukaryota

SRHMM017205-3 FTGRP_1 SRHMM017205-3 FTGRP_2 SRHMM017205-3 FTGRP_3 SRHMM017205-3 FTGRP_4 SRHMM017205-3 FTGRP_5 Disulfide bond SRHMM017205-3 C-x(4)-C Redox-active SRHMM017205-3 C-x(144)-C SRHMM017205-3 C-x(22)-C SRHMM017205-3 C-x(2)-C Redox-active SRHMM017205-3 C-x(258)-c 1 PIRSR017250-50 Domain

PIRSF017250 Eukaryota

SRHMM017250-50 Y H K 1 PIRSR017267-1 Domain

PIRSF017267 Eukaryota

SRHMM017267-1 FTGRP_1 ATP-binding Nucleotide-binding SRHMM017267-1 G-x(2)-R ATP 1 PIRSR017267-2 Domain

PIRSF017267 Eukaryota

SRHMM017267-2 FTGRP_1 Disulfide bond SRHMM017267-2 C Interchain 1 PIRSR017269-1 Domain

PIRSF017269 Eukaryota Bacteria Archaea

SRHMM017269-1 FTGRP_1 SRHMM017269-1 FTGRP_2 SRHMM017269-1 FTGRP_3 SRHMM017269-1 FTGRP_4 SRHMM017269-1 FTGRP_5 S-adenosyl-L-methionine SRHMM017269-1 H S-adenosyl-L-methionine SRHMM017269-1 D S-adenosyl-L-methionine SRHMM017269-1 S-x(2)-L S-adenosyl-L-methionine binding SRHMM017269-1 D S-adenosyl-L-methionine SRHMM017269-1 [ED] S-adenosyl-L-methionine 1 PIRSR017340-1 Domain

PIRSF017340 Bacteria

SRHMM017340-1 FTGRP_1 SRHMM017340-1 FTGRP_2 Magnesium Metal-binding SRHMM017340-1 E Magnesium SRHMM017340-1 E Magnesium 1 PIRSR017388-1 Domain

PIRSF017388 Bacteria

SRHMM017388-1 S Nucleophile D Charge relay system H Charge relay system 1 PIRSR017388-2 Domain

PIRSF017388 Bacteria

SRHMM017388-2 F Substrate; via amide nitrogen M Substrate; via amide nitrogen 1 PIRSR017388-3 Domain

PIRSF017388 Bacteria

SRHMM017388-3 I Important for substrate specificity 1 PIRSR017434-1 Domain

PIRSF017434 Eukaryota

SRHMM017434-1 D Nucleophile D Proton donor 1 PIRSR017434-2 Domain

PIRSF017434 Eukaryota

SRHMM017434-2 FTGRP_1 SRHMM017434-2 FTGRP_2 SRHMM017434-2 FTGRP_3 Metal-binding Magnesium Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM017434-2 D Magnesium SRHMM017434-2 D Magnesium; via carbonyl oxygen SRHMM017434-2 D Magnesium 1 PIRSR017570-1 Domain

PIRSF017570 Fungi

SRHMM017570-1 FTGRP_1 SRHMM017570-1 FTGRP_2 SRHMM017570-1 FTGRP_3 SRHMM017570-1 FTGRP_4 S-adenosyl-L-methionine SRHMM017570-1 E S-adenosyl-L-methionine SRHMM017570-1 [SD]-F S-adenosyl-L-methionine binding SRHMM017570-1 Y-x(2)-L S-adenosyl-L-methionine binding SRHMM017570-1 F-x-D-x-G-x(4)-N S-adenosyl-L-methionine binding 1 PIRSR017617-1 Domain

PIRSF017617 Eukaryota Bacteria Archaea

SRHMM017617-1 K N6-(pyridoxal phosphate)lysine 1 PIRSR017632-1 Domain

PIRSF017632 Eukaryota

SRHMM017632-1 C Nucleophile 1 PIRSR017632-2 Domain

PIRSF017632 Eukaryota

SRHMM017632-2 N-x-[ST] N-linked (GlcNAc...) asparagine N-x-[ST] N-linked (GlcNAc...) asparagine N-x-[ST] N-linked (GlcNAc...) asparagine N-x-[ST] N-linked (GlcNAc...) asparagine 1 PIRSR017689-1 Domain

PIRSF017689 Eukaryota Archaea

SRHMM017689-1 R Pyridoxal phosphate R Substrate S Substrate Q Substrate [RK] tRNA variable arm [RK] Substrate [RK] tRNA discriminator base [KR] tRNA acceptor arm 1 PIRSR017689-50 Domain This rule was created based on analysis for RESID:AA0119.

PIRSF017689 Eukaryota Archaea

SRHMM017689-50 FTGRP_1 Pyridoxal phosphate RNA-binding tRNA-binding pyridoxal 5'-phosphate SRHMM017689-50 K tRNA acceptor arm SRHMM017689-50 R Substrate SRHMM017689-50 R tRNA variable arm SRHMM017689-50 Q Substrate SRHMM017689-50 E May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate R Pyridoxal phosphate S Substrate R Substrate K N6-(pyridoxal phosphate)lysine SRHMM017689-50 R tRNA discriminator base 1 PIRSR017818-1 Domain

PIRSF017818 Bacteria

SRHMM017818-1 D Nucleophile D Proton donor 1 PIRSR017818-2 Domain

PIRSF017818 Bacteria

SRHMM017818-2 T-G Substrate binding K Substrate 1 PIRSR017818-3 Domain

PIRSF017818 Bacteria

SRHMM017818-3 FTGRP_1 SRHMM017818-3 FTGRP_2 SRHMM017818-3 FTGRP_3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM017818-3 D Magnesium; via carbonyl oxygen SRHMM017818-3 D Magnesium SRHMM017818-3 D Magnesium 1 PIRSR017901-50 Domain

PIRSF017901 Viridiplantae Bacteria

SRHMM017901-50 FTGRP_1 SRHMM017901-50 FTGRP_2 Disulfide bond SRHMM017901-50 C-x(219)-C SRHMM017901-50 C-x(14)-C 1 PIRSR018001-1 Domain

PIRSF018001 Eukaryota Bacteria

SRHMM018001-1 E 1 PIRSR018001-2 Domain

PIRSF018001 Eukaryota Bacteria

SRHMM018001-2 R Substrate N-R Substrate binding Y-x(3)-R Substrate binding E Substrate Y Substrate 1 PIRSR018001-3 Domain

PIRSF018001 Eukaryota Bacteria

SRHMM018001-3 FTGRP_1 SRHMM018001-3 FTGRP_2 SRHMM018001-3 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM018001-3 H Zinc SRHMM018001-3 E Zinc SRHMM018001-3 H Zinc 1 PIRSR018063-50 Domain

PIRSF018063 Bacteria Archaea

SRHMM018063-50 FTGRP_1 Iron Metal-binding SRHMM018063-50 E Iron H Iron E Iron E Iron H Iron 1 PIRSR018077-1 Domain

PIRSF018077 Bacteria

SRHMM018077-1 D Proton acceptor 1 PIRSR018136-1 Domain

PIRSF018136 Eukaryota

SRHMM018136-1 C-x(33)-C 1 PIRSR018153-1 Domain

PIRSF018153 Eukaryota

SRHMM018153-1 E Nucleophile 1 PIRSR018168-1 Domain

PIRSF018168 Eukaryota Bacteria

SRHMM018168-1 E Proton donor E Nucleophile 1 PIRSR018168-2 Domain

PIRSF018168 Eukaryota Bacteria

SRHMM018168-2 H Substrate W Substrate Y Substrate 1 PIRSR018168-3 Domain

PIRSF018168 Eukaryota Bacteria

SRHMM018168-3 H Plays an important role in maintaining the position of the catalytic nucleophile 1 PIRSR018169-1 Domain

PIRSF018169 Eukaryota

SRHMM018169-1 S Nucleophile D Charge relay system H Charge relay system 1 PIRSR018249-1 Domain

PIRSF018249 Bacteria

SRHMM018249-1 FTGRP_1 SRHMM018249-1 FTGRP_2 SRHMM018249-1 FTGRP_3 SRHMM018249-1 FTGRP_4 Metal-binding Zinc SRHMM018249-1 C Zinc SRHMM018249-1 H Zinc SRHMM018249-1 C Zinc SRHMM018249-1 C Zinc 1 PIRSR018249-2 Domain

PIRSF018249 Bacteria

SRHMM018249-2 FTGRP_1 SRHMM018249-2 FTGRP_2 SRHMM018249-2 FTGRP_3 S-adenosyl-L-methionine SRHMM018249-2 [YF] S-adenosyl-L-methionine SRHMM018249-2 [ET]-G S-adenosyl-L-methionine binding SRHMM018249-2 [HY] S-adenosyl-L-methionine 1 PIRSR018250-1 Domain

PIRSF018250 Eukaryota Bacteria

SRHMM018250-1 K Proton acceptor H Proton donor 1 PIRSR018250-3 Domain

PIRSF018250 Eukaryota Bacteria

SRHMM018250-3 FTGRP_1 SRHMM018250-3 FTGRP_2 SRHMM018250-3 FTGRP_3 SRHMM018250-3 FTGRP_4 SRHMM018250-3 FTGRP_5 SRHMM018250-3 FTGRP_6 SRHMM018250-3 FTGRP_7 NAD SRHMM018250-3 I-x(2)-L NAD SRHMM018250-3 Y NAD SRHMM018250-3 R NAD SRHMM018250-3 G-R NAD SRHMM018250-3 D NAD SRHMM018250-3 T NAD SRHMM018250-3 V NAD; via carbonyl oxygen 1 PIRSR018250-4 Domain

PIRSF018250 Eukaryota Bacteria

SRHMM018250-4 C-x(43)-C 1 PIRSR018425-1 Domain

PIRSF018425 Eukaryota

SRHMM018425-1 FTGRP_1 SRHMM018425-1 FTGRP_2 SRHMM018425-1 FTGRP_3 SRHMM018425-1 FTGRP_4 SRHMM018425-1 FTGRP_5 SRHMM018425-1 FTGRP_6 SRHMM018425-1 FTGRP_7 ATP-binding Nucleotide-binding SRHMM018425-1 Y ATP SRHMM018425-1 T ATP SRHMM018425-1 G-V ATP SRHMM018425-1 K ATP SRHMM018425-1 F-x-S ATP SRHMM018425-1 D ATP SRHMM018425-1 D-x-D ATP 1 PIRSR018425-2 Domain

PIRSF018425 Eukaryota

SRHMM018425-2 FTGRP_1 SRHMM018425-2 FTGRP_2 SRHMM018425-2 FTGRP_3 Magnesium Metal-binding Mg(2+) Binds 2 magnesium ions. Also active with manganese. SRHMM018425-2 D Magnesium 2; catalytic SRHMM018425-2 D Magnesium 1; catalytic D Magnesium 2; catalytic SRHMM018425-2 D Magnesium 1; catalytic D Magnesium 2; catalytic 1 PIRSR018427-1 Domain

PIRSF018427 Eukaryota Bacteria Archaea

SRHMM018427-1 C E 1 PIRSR018571-1 Domain

PIRSF018571 Bacteria

SRHMM018571-1 D 1 PIRSR018774-1 Domain

PIRSF018774 Bacteria Archaea

SRHMM018774-1 C For GATase activity 1 PIRSR019543-1 Domain

PIRSF019543 Bacteria

SRHMM019543-1 T Alpha-ketoglutarate R Alpha-ketoglutarate R Alpha-ketoglutarate 1 PIRSR019543-2 Domain

PIRSF019543 Bacteria

SRHMM019543-2 FTGRP_1 SRHMM019543-2 FTGRP_2 SRHMM019543-2 FTGRP_3 Iron Metal-binding SRHMM019543-2 E Iron SRHMM019543-2 H Iron SRHMM019543-2 H Iron 1 PIRSR019574-1 Domain

PIRSF019574 Bacteria

SRHMM019574-1 Y Spermidine SRHMM019574-1 D-x(2)-E Spermidine-binding SRHMM019574-1 E Spermidine SRHMM019574-1 Q Spermidine 1 PIRSR019634-50 Domain This rule was created based on analysis for RESID:AA0227.

PIRSF019634 Fungi

SRHMM019634-50 K N6-AMP-lysine intermediate 1 PIRSR019663-1 Domain

PIRSF019663 Eukaryota

SRHMM019663-1 H C Nucleophile 1 PIRSR019876-1 Domain

PIRSF019876 Bacteria

SRHMM019876-1 FTGRP_1 SRHMM019876-1 FTGRP_2 Metal-binding Heme Iron SRHMM019876-1 H Iron (heme axial ligand) SRHMM019876-1 Y Iron (heme axial ligand) 1 PIRSR021331-1 Domain

PIRSF021331 Bacteria

SRHMM021331-1 [LVI] Thiamine; via amide nitrogen and carbonyl oxygen T Thiamine 1 PIRSR021497-1 Domain

PIRSF021497 Bacteria

SRHMM021497-1 E Proton acceptor 1 PIRSR021497-2 Domain

PIRSF021497 Bacteria

SRHMM021497-2 Q alpha,alpha-trehalose E-x(5)-Q alpha,alpha-trehalose binding P alpha,alpha-trehalose; via carbonyl oxygen W alpha,alpha-trehalose 1 PIRSR022950-1 Domain

PIRSF022950 Eukaryota

SRHMM022950-1 S D H 1 PIRSR022993-1 Domain

PIRSF022993 Eukaryota

SRHMM022993-1 [YF] Interaction with Pro-rich sequence 1 PIRSR023956-1 Domain

PIRSF023956 Eukaryota Bacteria

SRHMM023956-1 FTGRP_1 S-adenosyl-L-methionine SRHMM023956-1 W-x(3)-W-x(6)-F S-adenosyl-L-methionine binding L S-adenosyl-L-methionine; via carbonyl oxygen E S-adenosyl-L-methionine S-I S-adenosyl-L-methionine binding R S-adenosyl-L-methionine 1 PIRSR024851-50 Domain

PIRSF024851 Pezizomycotina

SRHMM024851-50 H H 1 PIRSR024851-51 Domain

PIRSF024851 Pezizomycotina

SRHMM024851-51 F Substrate; via carbonyl oxygen SRHMM024851-51 Y Substrate SRHMM024851-51 Y Substrate SRHMM024851-51 N Substrate 1 PIRSR025648-1 Domain

PIRSF025648 Bacteria

SRHMM025648-1 FTGRP_1 SRHMM025648-1 FTGRP_2 SRHMM025648-1 FTGRP_3 SRHMM025648-1 FTGRP_4 SRHMM025648-1 FTGRP_5 NADP Nucleotide-binding SRHMM025648-1 Y-x(2)-[LIV] NADP SRHMM025648-1 W Substrate T Substrate R Substrate H Substrate N Substrate SRHMM025648-1 [SRT]-x-[RAKN] NADP SRHMM025648-1 [TS]-x-D NADP SRHMM025648-1 C-x(2)-[ST] NADP SRHMM025648-1 [TASV]-x(3)-P NADP 1 PIRSR025737-1 Domain

PIRSF025737 Archaea

SRHMM025737-1 C Acyl-thioester intermediate R Proton donor 1 PIRSR025737-2 Domain

PIRSF025737 Archaea

SRHMM025737-2 R Transition state stabilizer 1 PIRSR026389-1 Domain

PIRSF026389 Eukaryota

SRHMM026389-1 FTGRP_1 SRHMM026389-1 FTGRP_2 SRHMM026389-1 FTGRP_3 SRHMM026389-1 FTGRP_4 SRHMM026389-1 FTGRP_5 ATP-binding Nucleotide-binding SRHMM026389-1 L ADP; via amide nitrogen SRHMM026389-1 [ST] ADP; via carbonyl oxygen SRHMM026389-1 D ADP SRHMM026389-1 N-x(2)-K ADP SRHMM026389-1 K ADP 1 PIRSR026389-2 Domain

PIRSF026389 Eukaryota

SRHMM026389-2 FTGRP_1 SRHMM026389-2 FTGRP_2 Copper Metal-binding Cu cation Binds 1 copper ion per dimer. SRHMM026389-2 C Copper SRHMM026389-2 H Copper 1 PIRSR026389-3 Domain

PIRSF026389 Eukaryota

SRHMM026389-3 FTGRP_1 SRHMM026389-3 FTGRP_2 Disulfide bond SRHMM026389-3 C Interchain SRHMM026389-3 C Interchain 1 PIRSR026389-4 Domain

PIRSF026389 Eukaryota

SRHMM026389-4 K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) 1 PIRSR026534-1 Domain

PIRSF026534 Bacteria

SRHMM026534-1 D Proton acceptor E Proton donor 1 PIRSR026534-2 Domain

PIRSF026534 Bacteria

SRHMM026534-2 D Substrate G Substrate; via amide nitrogen N-x(2)-D Substrate binding S-x-W Substrate binding 1 PIRSR026534-3 Domain

PIRSF026534 Eukaryota Bacteria

SRHMM026534-3 D Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate H Important for substrate recognition 1 PIRSR026583-50 Domain

PIRSF026583 Firmicutes

SRHMM026583-50 FTGRP_1 Metal-binding Manganese Mn(2+) For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit. SRHMM026583-50 H Manganese 1 D Manganese 1 D Manganese 2 D Manganese 1 D Manganese 2 H Manganese 2 D Manganese 2 1 PIRSR027744-1 Domain

PIRSF027744 Eukaryota

SRHMM027744-1 R Phosphatidylinositol 4,5-bisphosphate K Phosphatidylinositol 4,5-bisphosphate K Phosphatidylinositol 4,5-bisphosphate R Phosphatidylinositol 4,5-bisphosphate 1 PIRSR028729-50 Domain

PIRSF028729 Mammalia

SRHMM028729-50 FTGRP_1 Ubl conjugation Isopeptide bond SRHMM028729-50 K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) 1 PIRSR028757-1 Domain

PIRSF028757 Bacteria

SRHMM028757-1 S Nucleophile E Charge relay system H Charge relay system 1 PIRSR028762-1 Domain

PIRSF028762 Eukaryota

SRHMM028762-1 K S-adenosyl-L-methionine [GAC] S-adenosyl-L-methionine; via carbonyl oxygen D S-adenosyl-L-methionine D S-adenosyl-L-methionine; via amide nitrogen Q S-adenosyl-L-methionine; via carbonyl oxygen Y S-adenosyl-L-methionine 1 PIRSR028762-2 Domain

PIRSF028762 Eukaryota

SRHMM028762-2 FTGRP_1 mRNA capping SRHMM028762-2 N-N mRNA cap binding K mRNA cap binding K mRNA cap binding R mRNA cap binding H mRNA cap binding E mRNA cap binding Y mRNA cap binding 1 PIRSR028774-1 Domain

PIRSF028774 Bacteria

SRHMM028774-1 K Proton acceptor 1 PIRSR028774-2 Domain

PIRSF028774 Bacteria

SRHMM028774-2 FTGRP_1 SRHMM028774-2 FTGRP_2 SRHMM028774-2 FTGRP_3 SRHMM028774-2 FTGRP_4 SRHMM028774-2 FTGRP_5 S-adenosyl-L-methionine SRHMM028774-2 D S-adenosyl-L-methionine SRHMM028774-2 [CSA]-x(2)-G S-adenosyl-L-methionine binding SRHMM028774-2 D S-adenosyl-L-methionine SRHMM028774-2 D S-adenosyl-L-methionine SRHMM028774-2 S S-adenosyl-L-methionine 1 PIRSR028937-1 Domain

PIRSF028937 Eukaryota

SRHMM028937-1 H Proton acceptor 1 PIRSR028937-2 Domain

PIRSF028937 Eukaryota

SRHMM028937-2 FTGRP_1 FAD SRHMM028937-2 C-x(14)-A FAD 1 PIRSR028973-1 Domain

PIRSF028973 Eukaryota

SRHMM028973-1 H Nucleophile 1 PIRSR028973-2 Domain

PIRSF028973 Eukaryota

SRHMM028973-2 W Substrate E Substrate D Substrate K Substrate H-x(6)-H-x-H-x-H Substrate binding 1 PIRSR028980-1 Domain

PIRSF028980 Eukaryota

SRHMM028980-1 FTGRP_1 SRHMM028980-1 FTGRP_2 GTP-binding Nucleotide-binding SRHMM028980-1 S-D GTP SRHMM028980-1 D-x(4)-H GTP 1 PIRSR028980-2 Domain

PIRSF028980 Eukaryota

SRHMM028980-2 FTGRP_1 SRHMM028980-2 FTGRP_2 SRHMM028980-2 FTGRP_3 Magnesium Metal-binding Mg(2+) Binds 2 magnesium ions per subunit. SRHMM028980-2 D Magnesium 1; catalytic D Magnesium 2; catalytic SRHMM028980-2 G Magnesium 1; via carbonyl oxygen; catalytic SRHMM028980-2 D Magnesium 1; catalytic D Magnesium 2; catalytic 1 PIRSR029163-50 Domain

PIRSF029163 Proteobacteria

SRHMM029163-50 FTGRP_1 Disulfide bond SRHMM029163-50 C-x(5)-C 1 PIRSR029256-1 Domain

PIRSF029256 Bacteria

SRHMM029256-1 FTGRP_1 SRHMM029256-1 FTGRP_2 SRHMM029256-1 FTGRP_3 SRHMM029256-1 FTGRP_4 S-adenosyl-L-methionine SRHMM029256-1 [ILMV] S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen SRHMM029256-1 S S-adenosyl-L-methionine SRHMM029256-1 [LIMV] S-adenosyl-L-methionine; via carbonyl oxygen SRHMM029256-1 G S-adenosyl-L-methionine; via amide nitrogen 1 PIRSR029271-50 Domain

PIRSF029271 Eukaryota

SRHMM029271-50 FTGRP_1 Schiff base SRHMM029271-50 K Schiff-base intermediate with D-ribose 5-phosphate 1 PIRSR029271-51 Domain

PIRSF029271 Eukaryota

SRHMM029271-51 D D-ribose 5-phosphate G D-ribose 5-phosphate; via amide nitrogen R Glyceraldehyde 3-phosphate G D-ribose 5-phosphate; via amide nitrogen G-S D-ribose 5-phosphate binding 1 PIRSR029681-1 Domain

PIRSF029681 Bacteria

SRHMM029681-1 H Charge relay system S Charge relay system [ED] Charge relay system 1 PIRSR029681-2 Domain

PIRSF029681 Bacteria

SRHMM029681-2 N Critical for activity 1 PIRSR029775-1 Domain

PIRSF029775 Bacteria

SRHMM029775-1 R Substrate R Substrate K Substrate [QE] Substrate 1 PIRSR029792-1 Domain

PIRSF029792 Eukaryota Bacteria

SRHMM029792-1 S Proton acceptor C Proton donor 1 PIRSR029792-2 Domain

PIRSF029792 Eukaryota Bacteria

SRHMM029792-2 Q Substrate G-S Substrate binding D Substrate G-T Substrate binding 1 PIRSR029900-1 Domain

PIRSF029900 Eukaryota Bacteria

SRHMM029900-1 E Proton donor D Proton acceptor E Proton acceptor 1 PIRSR029928-50 Domain This rule was created based on analysis for RESID:AA0065.

PIRSF029928 Bacillales

SRHMM029928-50 FTGRP_1 Methylation SRHMM029928-50 F N-methylphenylalanine G F 1 PIRSR030150-1 Domain

PIRSF030150 Bacteria

SRHMM030150-1 C Acyl-thioester intermediate 1 PIRSR030150-2 Domain

PIRSF030150 Bacteria

SRHMM030150-2 R Transition state stablizer 1 PIRSR031051-1 Domain

PIRSF031051 Eukaryota

SRHMM031051-1 D Nucleophile D Proton donor 1 PIRSR031051-2 Domain

PIRSF031051 Eukaryota

SRHMM031051-2 D Substrate D Substrate 1 PIRSR031051-3 Domain

PIRSF031051 Eukaryota

SRHMM031051-3 FTGRP_1 SRHMM031051-3 FTGRP_2 SRHMM031051-3 FTGRP_3 Magnesium Metal-binding Mg(2+) SRHMM031051-3 D Magnesium SRHMM031051-3 D Magnesium SRHMM031051-3 D Magnesium 1 PIRSR031924-50 Domain

PIRSF031924 Bacteria

SRHMM031924-50 FTGRP_1 Phosphoprotein SRHMM031924-50 T Phosphothreonine intermediate 1 PIRSR031924-51 Domain

PIRSF031924 Bacteria

SRHMM031924-51 N Substrate K-x-R Substrate binding 1 PIRSR032067-1 Domain

PIRSF032067 Bacteria

SRHMM032067-1 S Charge relay system H Charge relay system E Charge relay system 1 PIRSR033579-1 Domain

PIRSF033579 Bacteria

SRHMM033579-1 H Proton acceptor 1 PIRSR033579-2 Domain

PIRSF033579 Bacteria

SRHMM033579-2 F Substrate I-x(6)-K Substrate binding L-V Substrate binding H Substrate 1 PIRSR033579-3 Domain

PIRSF033579 Bacteria

SRHMM033579-3 FTGRP_1 SRHMM033579-3 FTGRP_2 SRHMM033579-3 FTGRP_3 Cobalt Metal-binding SRHMM033579-3 H Cobalt SRHMM033579-3 H Cobalt SRHMM033579-3 E Cobalt 1 PIRSR034515-1 Domain

PIRSF034515 Bacteria

SRHMM034515-1 H Proton acceptor H Proton acceptor Y Proton donor 1 PIRSR034515-2 Domain

PIRSF034515 Bacteria

SRHMM034515-2 R Important for catalytic activity against all substrates H Important for catalytic activity against dermatan sulfate substrate R Transition state stabilizer E Important for catalytic activity against all substrates 1 PIRSR034515-3 Domain

PIRSF034515 Bacteria

SRHMM034515-3 FTGRP_1 SRHMM034515-3 FTGRP_2 SRHMM034515-3 FTGRP_3 SRHMM034515-3 FTGRP_4 SRHMM034515-3 FTGRP_5 Calcium Metal-binding SRHMM034515-3 S Calcium SRHMM034515-3 D Calcium; via carbonyl oxygen SRHMM034515-3 H Calcium; via carbonyl oxygen SRHMM034515-3 E Calcium SRHMM034515-3 D Calcium 1 PIRSR035805-1 Domain

PIRSF035805 Eukaryota Bacteria Archaea Viruses

SRHMM035805-1 E Proton acceptor 1 PIRSR036289-50 Domain

PIRSF036289 Bacteria

SRHMM036289-50 E Proton donor 1 PIRSR036289-51 Domain

PIRSF036289 Bacteria

SRHMM036289-51 W-D Substrate binding K-Q Substrate binding 1 PIRSR036298-50 Domain This rule was created based on analysis for RESID:AA0140.

PIRSF036298 Archaea Bacteria

SRHMM036298-50 FTGRP_1 4Fe-4S Metal-binding Iron-sulfur Iron [4Fe-4S] cluster Binds 4 [4Fe-4S] clusters per subunit. SRHMM036298-50 C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 4 (4Fe-4S) C Iron-sulfur 4 (4Fe-4S) C Iron-sulfur 4 (4Fe-4S) C Iron-sulfur 4 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) 1 PIRSR036370-1 Domain

PIRSF036370 Eukaryota

SRHMM036370-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR036376-50 Domain

PIRSF036376 Eukaryota

SRHMM036376-50 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR036417-1 Domain

PIRSF036417 Magnoliopsida

SRHMM036417-1 C H H H H N 1 PIRSR036421-1 Domain

PIRSF036421 Archaea Bacteria

SRHMM036421-1 H Charge relay system S Nucleophile E Charge relay system 1 PIRSR036421-2 Domain

PIRSF036421 Bacteria Archaea

SRHMM036421-2 R-R Binds the substrate's C-terminus [GA]-x-G Substrate binding [GA]-x-[TS] Substrate binding 1 PIRSR036421-3 Domain

PIRSF036421 Bacteria Archaea

SRHMM036421-3 D Transition state stabilizer; via amide nitrogen 1 PIRSR036426-1 Domain

PIRSF036426 Bacteria

SRHMM036426-1 D Proton acceptor K Proton donor 1 PIRSR036432-1 Domain

PIRSF036432 Archaea Eukaryota

SRHMM036432-1 FTGRP_1 SRHMM036432-1 FTGRP_2 SRHMM036432-1 FTGRP_3 SRHMM036432-1 FTGRP_4 SRHMM036432-1 FTGRP_5 SRHMM036432-1 FTGRP_6 SRHMM036432-1 FTGRP_7 S-adenosyl-L-methionine SRHMM036432-1 D S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen SRHMM036432-1 [HQY] S-adenosyl-L-methionine; via carbonyl oxygen SRHMM036432-1 [VILMGAT] S-adenosyl-L-methionine; via carbonyl oxygen SRHMM036432-1 [STN]-[IVGA] S-adenosyl-L-methionine binding SRHMM036432-1 [LIV] S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen SRHMM036432-1 [LI] S-adenosyl-L-methionine; via carbonyl oxygen SRHMM036432-1 [ALMV] S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen 1 PIRSR036441-50 Domain

PIRSF036441 Bacteria

SRHMM036441-50 A-G Substrate binding R Substrate N Substrate 1 PIRSR036441-51 Domain

PIRSF036441 Bacteria

SRHMM036441-51 K Transition state stabilizer K Transition state stabilizer 1 PIRSR036442-1 Domain

PIRSF036442 Eukaryota

SRHMM036442-1 K Substrate K Substrate R-x(4)-N Substrate binding 1 PIRSR036488-1 Domain

PIRSF036488 Eukaryota

SRHMM036488-1 FTGRP_1 Heme Iron Metal-binding SRHMM036488-1 H Iron (heme proximal ligand) 1 PIRSR036489-1 Domain

PIRSF036489 Eukaryota

SRHMM036489-1 H Proton donor E Proton acceptor C Proton donor 1 PIRSR036489-2 Domain

PIRSF036489 Eukaryota

SRHMM036489-2 Q-x-I Substrate binding D Substrate 1 PIRSR036489-3 Domain

PIRSF036489 Eukaryota

SRHMM036489-3 FTGRP_1 SRHMM036489-3 FTGRP_2 SRHMM036489-3 FTGRP_3 SRHMM036489-3 FTGRP_4 SRHMM036489-3 FTGRP_5 SRHMM036489-3 FTGRP_6 NADP SRHMM036489-3 K-x(2)-Q NADP SRHMM036489-3 K NADP SRHMM036489-3 I-x-W NADP SRHMM036489-3 E-x-F NADP SRHMM036489-3 G-x(4)-Q NADP SRHMM036489-3 G-S NADP 1 PIRSR036489-4 Domain

PIRSF036489 Eukaryota

SRHMM036489-4 D Essential for catalytic activity 1 PIRSR036492-1 Domain

PIRSF036492 Eukaryota Bacteria

SRHMM036492-1 E C 1 PIRSR036497-1 Domain

PIRSF036497 Archaea Eukaryota Bacteria

SRHMM036497-1 K Proton donor 1 PIRSR036497-2 Domain

PIRSF036497 Archaea Eukaryota Bacteria

SRHMM036497-2 FTGRP_1 SRHMM036497-2 FTGRP_2 SRHMM036497-2 FTGRP_3 NADP SRHMM036497-2 G-x(4)-G NADP SRHMM036497-2 K NADP SRHMM036497-2 E Substrate SRHMM036497-2 T NADP 1 PIRSR036503-50 Domain This rule was created based on analysis for RESID:AA0036.

PIRSF036503 Eukaryota

SRHMM036503-50 H Pros-phosphohistidine intermediate 1 PIRSR036503-51 Domain This rule was created based on analysis for RESID:AA0036.

PIRSF036503 Eukaryota

SRHMM036503-51 FTGRP_1 ATP-binding Nucleotide-binding SRHMM036503-51 K ATP F ATP R ATP N ATP 1 PIRSR036511-1 Domain

PIRSF036511 Eukaryota

SRHMM036511-1 H Tele-phosphohistidine intermediate 1 PIRSR036514-1 Domain

PIRSF036514 Eukaryota

SRHMM036514-1 FTGRP_1 SRHMM036514-1 FTGRP_2 SRHMM036514-1 FTGRP_3 SRHMM036514-1 FTGRP_4 SRHMM036514-1 FTGRP_5 Metal-binding Zinc SRHMM036514-1 H Zinc 1 SRHMM036514-1 H Zinc 1 SRHMM036514-1 H Zinc 2 SRHMM036514-1 E Zinc 2 SRHMM036514-1 H Zinc 1 1 PIRSR036517-1 Domain

PIRSF036517 Eukaryota

SRHMM036517-1 FTGRP_1 Heme Iron Metal-binding SRHMM036517-1 H Iron (heme proximal ligand) 1 PIRSR036517-2 Domain

PIRSF036517 Eukaryota

SRHMM036517-2 FTGRP_1 Disulfide bond SRHMM036517-2 C-x(130)-C 1 PIRSR036551-1 Domain

PIRSF036551 Bacteria

SRHMM036551-1 E Proton donor D Nucleophile 1 PIRSR036561-1 Domain

PIRSF036561 Eukaryota

SRHMM036561-1 K Substrate R Substrate R Substrate K Substrate R Substrate E Substrate K Substrate 1 PIRSR036561-2 Domain

PIRSF036561 Eukaryota

SRHMM036561-2 FTGRP_1 SRHMM036561-2 FTGRP_2 SRHMM036561-2 FTGRP_3 SRHMM036561-2 FTGRP_4 SRHMM036561-2 FTGRP_5 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM036561-2 E Magnesium SRHMM036561-2 D Magnesium SRHMM036561-2 E Magnesium SRHMM036561-2 E Magnesium SRHMM036561-2 E Magnesium 1 PIRSR036565-1 Domain

PIRSF036565 Eukaryota Bacteria

SRHMM036565-1 D Substrate H Substrate Y Substrate; allosteric site E Substrate 1 PIRSR036565-2 Domain

PIRSF036565 Eukaryota Bacteria Archaea

SRHMM036565-2 FTGRP_1 SRHMM036565-2 FTGRP_2 SRHMM036565-2 FTGRP_3 Metal-binding Magnesium Mg(2+) Binds 1 Mg(2+) per subunit. SRHMM036565-2 G Magnesium; via carbonyl oxygen SRHMM036565-2 N Magnesium SRHMM036565-2 D Magnesium 1 PIRSR036593-50 Domain

PIRSF036593 Bacteria

SRHMM036593-50 C 1 PIRSR036636-50 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF036636 Bacteria

SRHMM036636-50 FTGRP_1 Heme SRHMM036636-50 C Heme (covalent) C Heme (covalent) 1 PIRSR036636-51 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF036636 Bacteria

SRHMM036636-51 FTGRP_1 Heme Iron Metal-binding SRHMM036636-51 H Iron (heme axial ligand) 1 PIRSR036639-1 Domain

PIRSF036639 Eukaryota

SRHMM036639-1 FTGRP_1 SRHMM036639-1 FTGRP_2 SRHMM036639-1 FTGRP_4 SRHMM036639-1 FTGRP_5 ATP-binding Nucleotide-binding SRHMM036639-1 N Substrate SRHMM036639-1 K-x(5)-D ATP SRHMM036639-1 R ATP SRHMM036639-1 Q ATP SRHMM036639-1 H ATP 1 PIRSR036665-50 Domain This rule was created based on analysis for RESID:AA0185.

PIRSF036665 Chordata

SRHMM036665-50 FTGRP_1 The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. SRHMM036665-50 C 3-oxoalanine (Cys) 1 PIRSR036665-51 Domain

PIRSF036665 Chordata

SRHMM036665-51 C Nucleophile 1 PIRSR036665-52 Domain

PIRSF036665 Chordata

SRHMM036665-52 FTGRP_1 Calcium Metal-binding Ca(2+) Binds 1 Ca(2+) ion per subunit. SRHMM036665-52 D Calcium D Calcium C Calcium; via 3-oxoalanine D Calcium H Calcium 1 PIRSR036666-50 Domain This rule was created based on analysis for RESID:AA0185.

PIRSF036666 Bacteria Eukaryota

SRHMM036666-50 FTGRP_1 The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. SRHMM036666-50 C 3-oxoalanine (Cys) 1 PIRSR036684-1 Domain

PIRSF036684 Bacteria

SRHMM036684-1 K Proton acceptor 1 PIRSR036684-2 Domain

PIRSF036684 Bacteria

SRHMM036684-2 FTGRP_1 SRHMM036684-2 FTGRP_2 Metal-binding SRHMM036684-2 D Divalent metal cation SRHMM036684-2 E Divalent metal cation 1 PIRSR036684-3 Domain

PIRSF036684 Bacteria

SRHMM036684-3 FTGRP_1 SRHMM036684-3 FTGRP_2 SRHMM036684-3 FTGRP_3 NADP SRHMM036684-3 [VI]-x(6)-G NADP SRHMM036684-3 N NADP SRHMM036684-3 D NADP 1 PIRSR036685-1 Domain

PIRSF036685 Bacteria

SRHMM036685-1 FTGRP_1 SRHMM036685-1 FTGRP_2 SRHMM036685-1 FTGRP_3 SRHMM036685-1 FTGRP_4 SRHMM036685-1 FTGRP_5 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. SRHMM036685-1 H Zinc 1 SRHMM036685-1 D Zinc 1 SRHMM036685-1 H Zinc 2; catalytic SRHMM036685-1 D Zinc 1 SRHMM036685-1 E Zinc 2; catalytic 1 PIRSR036685-2 Domain

PIRSF036685 Bacteria

SRHMM036685-2 FTGRP_1 Disulfide bond SRHMM036685-2 C-x(3)-C 1 PIRSR036687-1 Domain

PIRSF036687 Bacteria

SRHMM036687-1 FTGRP_1 SRHMM036687-1 FTGRP_2 SRHMM036687-1 FTGRP_3 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster per subunit. SRHMM036687-1 C Iron-sulfur (4Fe-4S) SRHMM036687-1 C Iron-sulfur (4Fe-4S) SRHMM036687-1 C Iron-sulfur (4Fe-4S) 1 PIRSR036687-2 Domain

PIRSF036687 Bacteria

SRHMM036687-2 R Substrate S-x-R Substrate binding Q-x-T Substrate binding S Substrate R Substrate R Substrate 1 PIRSR036750-1 Domain

PIRSF036750 Viruses

SRHMM036750-1 C 1 PIRSR036767-51 Domain

PIRSF036767 Eukaryota Bacteria

SRHMM036767-51 FTGRP_1 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) per subunit. SRHMM036767-51 D Zinc 1 H Zinc 1 D Zinc 1 D Zinc 2 N Zinc 2 H Zinc 2 H Zinc 2 H Zinc 1 1 PIRSR036874-50 Domain

PIRSF036874 Viruses

SRHMM036874-50 FTGRP_1 Disulfide bond SRHMM036874-50 C-x(555)-C Interchain (between GP1 and GP2 chains) C-x(26)-C C-x(25)-C C-x(44)-C C-x(6)-C 1 PIRSR036874-51 Domain This rule was created based on analysis for RESID:AA0106.

PIRSF036874 Viruses

SRHMM036874-51 FTGRP_1 SRHMM036874-51 FTGRP_2 SRHMM036874-51 FTGRP_3 Lipoprotein Palmitate SRHMM036874-51 C S-palmitoyl cysteine; by host SRHMM036874-51 C S-palmitoyl cysteine; by host SRHMM036874-51 C S-palmitoyl cysteine; by host 1 PIRSR036893-50 Domain

PIRSF036893 Eukaryota Bacteria

SRHMM036893-50 FTGRP_1 Disulfide bond SRHMM036893-50 C-x(155)-C C-x(103)-C C-x(8)-C 1 PIRSR036893-51 Domain

PIRSF036893 Eukaryota Bacteria

SRHMM036893-51 Q Substrate 1 PIRSR036894-1 Domain

PIRSF036894 Bacteria

SRHMM036894-1 FTGRP_1 SRHMM036894-1 FTGRP_2 SRHMM036894-1 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM036894-1 H Zinc SRHMM036894-1 H Zinc SRHMM036894-1 E Zinc 1 PIRSR036894-2 Domain

PIRSF036894 Bacteria

SRHMM036894-2 FTGRP_1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM036894-2 R 1 PIRSR036900-50 Domain

PIRSF036900 Viruses

SRHMM036900-50 C For ubiquitin thioesterase activity H For ubiquitin thioesterase activity 1 PIRSR036917-1 Domain

PIRSF036917 Bacteria

SRHMM036917-1 D Nucleophile E Proton donor 1 PIRSR036917-2 Domain

PIRSF036917 Bacteria

SRHMM036917-2 FTGRP_1 SRHMM036917-2 FTGRP_2 Calcium Metal-binding Ca(2+) Binds 1 Ca(2+) ion per subunit. SRHMM036917-2 N Calcium SRHMM036917-2 H Calcium; via carbonyl oxygen 1 PIRSR036917-3 Domain

PIRSF036917 Bacteria

SRHMM036917-3 D Transition state stabilizer 1 PIRSR036917-4 Domain

PIRSF036917 Bacteria

SRHMM036917-4 FTGRP_1 SRHMM036917-4 FTGRP_2 Disulfide bond SRHMM036917-4 C-x(415)-C SRHMM036917-4 C-x(17)-C 1 PIRSR036918-50 Domain

PIRSF036918 Bacteria

SRHMM036918-50 D Nucleophile E Proton donor 1 PIRSR036918-51 Domain

PIRSF036918 Bacteria

SRHMM036918-51 D Transition state stabilizer 1 PIRSR036936-1 Domain

PIRSF036936 Eukaryota

SRHMM036936-1 C For GATase activity H For GATase activity E For GATase activity D D 1 PIRSR036936-2 Domain

PIRSF036936 Eukaryota

SRHMM036936-2 C Glutamine (covalent) G Substrate; via amide nitrogen G-[TS] PRFAR binding S-x-D PRFAR binding N Substrate D-G PRFAR binding S-G PRFAR binding A-G PRFAR binding 1 PIRSR036958-1 Domain

PIRSF036958 Eukaryota

SRHMM036958-1 C Phosphocysteine intermediate 1 PIRSR036958-2 Domain

PIRSF036958 Eukaryota

SRHMM036958-2 K N6-GMP-lysine intermediate 1 PIRSR036958-3 Domain

PIRSF036958 Eukaryota

SRHMM036958-3 FTGRP_1 SRHMM036958-3 FTGRP_2 SRHMM036958-3 FTGRP_3 SRHMM036958-3 FTGRP_4 SRHMM036958-3 FTGRP_5 GTP-binding Nucleotide-binding SRHMM036958-3 R GTP SRHMM036958-3 R GTP SRHMM036958-3 K-x-K GTP SRHMM036958-3 R-x(4)-K GTP SRHMM036958-3 D-x-E GTP 1 PIRSR036959-1 Domain

PIRSF036959 Eukaryota

SRHMM036959-1 K N6-GMP-lysine intermediate 1 PIRSR036960-1 Domain

PIRSF036960 Eukaryota

SRHMM036960-1 FTGRP_1 SRHMM036960-1 FTGRP_2 SRHMM036960-1 FTGRP_3 Calcium Metal-binding SRHMM036960-1 D Calcium SRHMM036960-1 D Calcium SRHMM036960-1 E Calcium 1 PIRSR036960-2 Domain

PIRSF036960 Eukaryota

SRHMM036960-2 FTGRP_1 SRHMM036960-2 FTGRP_2 SRHMM036960-2 FTGRP_3 SRHMM036960-2 FTGRP_4 SRHMM036960-2 FTGRP_5 SRHMM036960-2 FTGRP_6 Disulfide bond SRHMM036960-2 C-x(21)-C SRHMM036960-2 C-x(157)-C SRHMM036960-2 C-x(21)-C SRHMM036960-2 C-x(26)-C SRHMM036960-2 C-x(149)-C SRHMM036960-2 C-x(25)-C 1 PIRSR037010-50 Domain

PIRSF037010 Vertebrata

SRHMM037010-50 FTGRP_1 RNA-binding SRHMM037010-50 Y Interaction with RNA G Interaction with RNA 1 PIRSR037014-1 Domain

PIRSF037014 Eukaryota

SRHMM037014-1 D Proton acceptor 1 PIRSR037014-2 Domain

PIRSF037014 Eukaryota

SRHMM037014-2 FTGRP_1 SRHMM037014-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM037014-2 K ATP SRHMM037014-2 L-x(7)-V ATP 1 PIRSR037023-1 Domain

PIRSF037023 Eukaryota

SRHMM037023-1 S Nucleophile H 1 PIRSR037031-50 Domain

PIRSF037031 Bacteria Archaea

SRHMM037031-50 C Nucleophile C Nucleophile 1 PIRSR037031-51 Domain

PIRSF037031 Bacteria Archaea

SRHMM037031-51 FTGRP_1 Disulfide bond Redox-active center SRHMM037031-51 C-x(2)-C Redox-active 1 PIRSR037032-1 Domain

PIRSF037032 Eukaryota

SRHMM037032-1 FTGRP_1 SRHMM037032-1 FTGRP_2 SRHMM037032-1 FTGRP_3 SRHMM037032-1 FTGRP_4 NAD NADP SRHMM037032-1 S-x(2)-H NAD or NADP SRHMM037032-1 Y NAD or NADP; via carbonyl oxygen SRHMM037032-1 G-x-G-x(2)-G NAD or NADP SRHMM037032-1 S-x-R NAD or NADP 1 PIRSR037038-1 Domain

PIRSF037038 Eukaryota

SRHMM037038-1 FTGRP_1 SRHMM037038-1 FTGRP_2 SRHMM037038-1 FTGRP_3 Disulfide bond SRHMM037038-1 C-x(49)-C Interchain (between B and A chains) SRHMM037038-1 C-x(50)-C Interchain (between B and A chains) SRHMM037038-1 C-x(4)-C 1 PIRSR037038-2 Domain

PIRSF037038 Eukaryota

SRHMM037038-2 FTGRP_1 Pyrrolidone carboxylic acid SRHMM037038-2 Q Pyrrolidone carboxylic acid 1 PIRSR037091-1 Domain

PIRSF037091 Eukaryota

SRHMM037091-1 Y Phosphatidylinositol 3,4,5-trisphosphate SRHMM037091-1 K-x(3)-K Phosphatidylinositol 3,4,5-trisphosphate binding SRHMM037091-1 R-G Phosphatidylinositol 3,4,5-trisphosphate binding SRHMM037091-1 K Phosphatidylinositol 3,4,5-trisphosphate 1 PIRSR037123-1 Domain

PIRSF037123 Eukaryota

SRHMM037123-1 Y-x(2)-T S-adenosyl-L-methionine binding F-x-D-x-G-x(4)-Q S-adenosyl-L-methionine binding E S-adenosyl-L-methionine D-F S-adenosyl-L-methionine binding 1 PIRSR037125-1 Domain

PIRSF037125 Eukaryota

SRHMM037125-1 FTGRP_1 SRHMM037125-1 FTGRP_2 SRHMM037125-1 FTGRP_3 SRHMM037125-1 FTGRP_4 Metal-binding Zinc SRHMM037125-1 C Zinc SRHMM037125-1 C Zinc SRHMM037125-1 C Zinc SRHMM037125-1 C Zinc 1 PIRSR037177-1 Domain

PIRSF037177 Eukaryota

SRHMM037177-1 FTGRP_1 SRHMM037177-1 FTGRP_2 SRHMM037177-1 FTGRP_3 SRHMM037177-1 FTGRP_4 SRHMM037177-1 FTGRP_5 S-adenosyl-L-methionine SRHMM037177-1 G-x-[ST]-Q S-adenosyl-L-methionine binding SRHMM037177-1 D S-adenosyl-L-methionine SRHMM037177-1 E S-adenosyl-L-methionine SRHMM037177-1 V S-adenosyl-L-methionine; via amide nitrogen SRHMM037177-1 S S-adenosyl-L-methionine 1 PIRSR037177-2 Domain

PIRSF037177 Eukaryota

SRHMM037177-2 K Substrate N Substrate E Substrate 1 PIRSR037177-3 Domain

PIRSF037177 Eukaryota

SRHMM037177-3 FTGRP_1 SRHMM037177-3 FTGRP_2 SRHMM037177-3 FTGRP_3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM037177-3 D Magnesium SRHMM037177-3 N Magnesium SRHMM037177-3 D Magnesium 1 PIRSR037210-1 Domain

PIRSF037210 Bacteria

SRHMM037210-1 C D H 1 PIRSR037215-1 Domain

PIRSF037215 Bacteria

SRHMM037215-1 D E Proton acceptor 1 PIRSR037215-2 Domain

PIRSF037215 Bacteria

SRHMM037215-2 FTGRP_1 SRHMM037215-2 FTGRP_2 SRHMM037215-2 FTGRP_3 SRHMM037215-2 FTGRP_4 SRHMM037215-2 FTGRP_5 SRHMM037215-2 FTGRP_6 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. SRHMM037215-2 D Zinc 2 SRHMM037215-2 D Zinc 1 SRHMM037215-2 H Zinc 2 SRHMM037215-2 H Zinc 1 SRHMM037215-2 E Zinc 2 SRHMM037215-2 D Zinc 1 1 PIRSR037217-1 Domain

PIRSF037217 Eukaryota

SRHMM037217-1 D E Proton acceptor 1 PIRSR037217-2 Domain

PIRSF037217 Eukaryota

SRHMM037217-2 FTGRP_1 SRHMM037217-2 FTGRP_2 SRHMM037217-2 FTGRP_3 SRHMM037217-2 FTGRP_4 SRHMM037217-2 FTGRP_5 Metal-binding Zinc SRHMM037217-2 D Zinc 2 SRHMM037217-2 H Zinc 1 SRHMM037217-2 H Zinc 2 SRHMM037217-2 D Zinc 1 D Zinc 2 SRHMM037217-2 E Zinc 1 1 PIRSR037219-1 Domain

PIRSF037219 Bacteria

SRHMM037219-1 FTGRP_1 Heme Iron Metal-binding heme SRHMM037219-1 C Iron (heme axial ligand) 1 PIRSR037238-1 Domain

PIRSF037238 Bacteria

SRHMM037238-1 D E Proton acceptor 1 PIRSR037242-1 Domain

PIRSF037242 Eukaryota

SRHMM037242-1 D E Proton acceptor 1 PIRSR037242-2 Domain

PIRSF037242 Eukaryota

SRHMM037242-2 D Substrate; via carbonyl oxygen H Substrate; shared with homodimeric partner T Substrate; shared with homodimeric partner R Substrate S Substrate; via amide nitrogen and carbonyl oxygen H Substrate 1 PIRSR037242-3 Domain

PIRSF037242 Eukaryota

SRHMM037242-3 FTGRP_1 SRHMM037242-3 FTGRP_2 SRHMM037242-3 FTGRP_3 SRHMM037242-3 FTGRP_4 SRHMM037242-3 FTGRP_5 Manganese Metal-binding Mn(2+) Binds 2 manganese ions per subunit. SRHMM037242-3 D Manganese 2 SRHMM037242-3 D Manganese 1 D Manganese 2 SRHMM037242-3 H Manganese 2 SRHMM037242-3 E Manganese 1 SRHMM037242-3 H Manganese 1 1 PIRSR037242-4 Domain

PIRSF037242 Eukaryota

SRHMM037242-4 H Important for catalytic activity 1 PIRSR037249-1 Domain

PIRSF037249 Eukaryota

SRHMM037249-1 A-x-E S-adenosyl-L-methionine binding N-H S-adenosyl-L-methionine binding [EQ] S-adenosyl-L-methionine; via carbonyl oxygen 1 PIRSR037249-2 Domain

PIRSF037249 Eukaryota

SRHMM037249-2 Y Substrate [DE]-x-R Substrate binding T-x-S Substrate binding K Substrate Y Substrate; via carbonyl oxygen 1 PIRSR037250-50 Domain

PIRSF037250 Bacteria

SRHMM037250-50 E Proton donor/acceptor 1 PIRSR037250-51 Domain

PIRSF037250 Bacteria

SRHMM037250-51 FTGRP_1 Metal-binding Zinc SRHMM037250-51 H Zinc; via pros nitrogen H Zinc; via tele nitrogen; shared with neighboring monomer H Zinc; via tele nitrogen 1 PIRSR037250-52 Domain

PIRSF037250 Bacteria

SRHMM037250-52 FTGRP_1 Disulfide bond SRHMM037250-52 C-x(5)-C 1 PIRSR037250-53 Domain

PIRSF037250 Bacteria

SRHMM037250-53 FTGRP_1 Disulfide bond SRHMM037250-53 C-x(17)-C C-x(17)-C 1 PIRSR037251-1 Domain

PIRSF037251 Eukaryota

SRHMM037251-1 S D H 1 PIRSR037254-1 Domain

PIRSF037254 Eukaryota

SRHMM037254-1 FTGRP_1 SRHMM037254-1 FTGRP_2 SRHMM037254-1 FTGRP_3 SRHMM037254-1 FTGRP_4 Disulfide bond SRHMM037254-1 C-x(49)-C SRHMM037254-1 C-x(49)-C SRHMM037254-1 C-x(57)-C SRHMM037254-1 C-x(55)-C 1 PIRSR037281-1 Domain

PIRSF037281 Eukaryota

SRHMM037281-1 D Proton acceptor 1 PIRSR037281-2 Domain

PIRSF037281 Eukaryota

SRHMM037281-2 FTGRP_1 SRHMM037281-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM037281-2 I-x(7)-V ATP SRHMM037281-2 K ATP 1 PIRSR037281-3 Domain

PIRSF037281 Eukaryota

SRHMM037281-3 FTGRP_1 SRHMM037281-3 FTGRP_2 Magnesium Metal-binding Mg(2+) Binds 2 magnesium ions per subunit. SRHMM037281-3 N Magnesium; via carbonyl oxygen SRHMM037281-3 D Magnesium; via carbonyl oxygen 1 PIRSR037293-1 Domain

PIRSF037293 Eukaryota

SRHMM037293-1 FTGRP_1 SRHMM037293-1 FTGRP_2 SRHMM037293-1 FTGRP_3 SRHMM037293-1 FTGRP_4 Disulfide bond SRHMM037293-1 C-x(2)-C Redox-active SRHMM037293-1 C-x(2)-C Redox-active SRHMM037293-1 C-x(2)-C Redox-active SRHMM037293-1 C-x(2)-C Redox-active 1 PIRSR037299-1 Domain

PIRSF037299 Eukaryota

SRHMM037299-1 E Nucleophile E Proton donor 1 PIRSR037299-2 Domain

PIRSF037299 Eukaryota

SRHMM037299-2 FTGRP_1 Disulfide bond SRHMM037299-2 C-x(6)-C 1 PIRSR037303-2 Domain

PIRSF037303 Eukaryota

SRHMM037303-2 K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) 1 PIRSR037318-50 Domain

PIRSF037318 Proteobacteria

SRHMM037318-50 D 1 PIRSR037322-1 Domain

PIRSF037322 Eukaryota

SRHMM037322-1 C Phosphocysteine intermediate 1 PIRSR037350-1 Domain

PIRSF037350 Eukaryota

SRHMM037350-1 FTGRP_1 SRHMM037350-1 FTGRP_2 SRHMM037350-1 FTGRP_3 SRHMM037350-1 FTGRP_4 S-adenosyl-L-methionine SRHMM037350-1 [ED] S-adenosyl-L-methionine SRHMM037350-1 G S-adenosyl-L-methionine; via carbonyl oxygen SRHMM037350-1 N S-adenosyl-L-methionine SRHMM037350-1 [RK] S-adenosyl-L-methionine 1 PIRSR037375-1 Domain

PIRSF037375 Bacteria

SRHMM037375-1 S Nucleophile [DN] Charge relay system H Charge relay system 1 PIRSR037393-1 Domain

PIRSF037393 Eukaryota

SRHMM037393-1 D Proton acceptor 1 PIRSR037393-2 Domain

PIRSF037393 Eukaryota

SRHMM037393-2 FTGRP_1 SRHMM037393-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM037393-2 K ATP SRHMM037393-2 V-G-x-G-x(4)-V ATP 1 PIRSR037393-3 Domain

PIRSF037393 Eukaryota

SRHMM037393-3 FTGRP_1 SRHMM037393-3 FTGRP_2 SRHMM037393-3 FTGRP_3 SRHMM037393-3 FTGRP_4 SRHMM037393-3 FTGRP_5 SRHMM037393-3 FTGRP_6 Disulfide bond SRHMM037393-3 C-x(4)-C SRHMM037393-3 C-x(16)-C SRHMM037393-3 C-x(32)-C SRHMM037393-3 C-x(14)-C SRHMM037393-3 C-x(23)-C SRHMM037393-3 C-x(5)-C 1 PIRSR037403-1 Domain

PIRSF037403 Eukaryota

SRHMM037403-1 FTGRP_1 SRHMM037403-1 FTGRP_2 SRHMM037403-1 FTGRP_3 SRHMM037403-1 FTGRP_4 Disulfide bond SRHMM037403-1 C-x(66)-C SRHMM037403-1 C Interchain SRHMM037403-1 C-x(67)-C SRHMM037403-1 C-x(69)-C 1 PIRSR037404-1 Domain

PIRSF037404 Eukaryota

SRHMM037404-1 C 1 PIRSR037404-3 Domain

PIRSF037404 Eukaryota

SRHMM037404-3 FTGRP_1 Metal-binding Zinc SRHMM037404-3 C Zinc C Zinc C Zinc H Zinc 1 PIRSR037430-1 Domain

PIRSF037430 Eukaryota

SRHMM037430-1 H E Proton acceptor H Proton donor 1 PIRSR037430-2 Domain

PIRSF037430 Eukaryota

SRHMM037430-2 FTGRP_1 SRHMM037430-2 FTGRP_2 Disulfide bond SRHMM037430-2 C-x(141)-C SRHMM037430-2 C-x(55)-C 1 PIRSR037432-50 Domain

PIRSF037432 Bacteria

SRHMM037432-50 FTGRP_1 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. SRHMM037432-50 C Iron-sulfur (4Fe-4S) C Iron-sulfur (4Fe-4S) C Iron-sulfur (4Fe-4S) C Iron-sulfur (4Fe-4S) 1 PIRSR037432-51 Domain

PIRSF037432 Bacteria

SRHMM037432-51 FTGRP_1 Phosphoprotein Autophosphorylated. SRHMM037432-51 H Phosphohistidine; by autocatalysis 1 PIRSR037470-50 Domain

PIRSF037470 Metazoa

SRHMM037470-50 S Nucleophile H 1 PIRSR037471-1 Domain

PIRSF037471 Eukaryota

SRHMM037471-1 FTGRP_1 SRHMM037471-1 FTGRP_2 SRHMM037471-1 FTGRP_3 SRHMM037471-1 FTGRP_4 Iron Metal-binding SRHMM037471-1 H Iron (heme axial ligand) SRHMM037471-1 H Iron (heme axial ligand) SRHMM037471-1 H Iron (heme axial ligand) SRHMM037471-1 H Iron (heme axial ligand) 1 PIRSR037479-1 Domain

PIRSF037479 Bacteria

SRHMM037479-1 D Proton acceptor H Proton donor 1 PIRSR037479-2 Domain

PIRSF037479 Bacteria

SRHMM037479-2 Y Substrate; via amide nitrogen 1 PIRSR037479-3 Domain

PIRSF037479 Bacteria

SRHMM037479-3 FTGRP_1 SRHMM037479-3 FTGRP_2 SRHMM037479-3 FTGRP_3 Metal-binding Zinc SRHMM037479-3 H Zinc; via tele nitrogen SRHMM037479-3 D Zinc SRHMM037479-3 H Zinc; via tele nitrogen 1 PIRSR037479-4 Domain

PIRSF037479 Bacteria

SRHMM037479-4 D Raises pKa of active site His 1 PIRSR037505-2 Domain

PIRSF037505 Bacteria Eukaryota

SRHMM037505-2 FTGRP_1 SRHMM037505-2 FTGRP_2 SRHMM037505-2 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM037505-2 C Zinc SRHMM037505-2 C Zinc SRHMM037505-2 C Zinc 1 PIRSR037506-1 Domain

PIRSF037506 Eukaryota

SRHMM037506-1 E Proton acceptor 1 PIRSR037568-1 Domain

PIRSF037568 Eukaryota

SRHMM037568-1 D Proton acceptor 1 PIRSR037568-2 Domain

PIRSF037568 Eukaryota

SRHMM037568-2 K ATP 1 PIRSR037575-1 Domain

PIRSF037575 Eukaryota

SRHMM037575-1 FTGRP_1 SRHMM037575-1 FTGRP_2 SRHMM037575-1 FTGRP_3 SRHMM037575-1 FTGRP_4 SRHMM037575-1 FTGRP_5 SRHMM037575-1 FTGRP_6 SRHMM037575-1 FTGRP_7 SRHMM037575-1 FTGRP_8 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. SRHMM037575-1 C Zinc 1 SRHMM037575-1 H Zinc 2 SRHMM037575-1 H Zinc 1 SRHMM037575-1 C Zinc 2 SRHMM037575-1 C Zinc 2 SRHMM037575-1 C Zinc 1 SRHMM037575-1 C Zinc 2 SRHMM037575-1 C Zinc 1 1 PIRSR037599-2 Domain

PIRSF037599 Bacteria

SRHMM037599-2 F-L Substrate binding F Substrate R Substrate 1 PIRSR037599-3 Domain

PIRSF037599 Bacteria

SRHMM037599-3 FTGRP_1 SRHMM037599-3 FTGRP_2 SRHMM037599-3 FTGRP_3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM037599-3 G Magnesium; via carbonyl oxygen SRHMM037599-3 E Magnesium SRHMM037599-3 Q Magnesium 1 PIRSR037599-4 Domain

PIRSF037599 Bacteria

SRHMM037599-4 G-x(5)-E-x(7)-R-x(4)-E-x-G Nudix box 1 PIRSR037634-1 Domain

PIRSF037634 Eukaryota

SRHMM037634-1 D-S Cleavage; by caspase-3 1 PIRSR037646-50 Domain

PIRSF037646 Mammalia

SRHMM037646-50 FTGRP_1 ATP-binding Nucleotide-binding SRHMM037646-50 G-x(6)-S ATP R ATP 1 PIRSR037736-1 Domain

PIRSF037736 Eukaryota

SRHMM037736-1 FTGRP_1 SRHMM037736-1 FTGRP_2 SRHMM037736-1 FTGRP_3 Copper Metal-binding SRHMM037736-1 C Copper SRHMM037736-1 H Copper SRHMM037736-1 C Copper 1 PIRSR037756-1 Domain

PIRSF037756 Eukaryota

SRHMM037756-1 S Phosphoserine 1 PIRSR037799-1 Domain

PIRSF037799 Bacteria

SRHMM037799-1 P Proton acceptor; via imino nitrogen 1 PIRSR037839-1 Domain

PIRSF037839 Bacteria

SRHMM037839-1 FTGRP_1 SRHMM037839-1 FTGRP_2 SRHMM037839-1 FTGRP_3 SRHMM037839-1 FTGRP_4 Mn(2+) Mg(2+) Binds 2 metal ions per subunit. Manganese or magnesium. Metal-binding Manganese Magnesium SRHMM037839-1 D Magnesium 1 SRHMM037839-1 D Magnesium 1 SRHMM037839-1 E Magnesium 2 SRHMM037839-1 D Magnesium 2 1 PIRSR037847-1 Domain

PIRSF037847 Bacteria

SRHMM037847-1 FTGRP_1 SRHMM037847-1 FTGRP_2 SRHMM037847-1 FTGRP_3 SRHMM037847-1 FTGRP_4 Metal-binding Nickel SRHMM037847-1 H Nickel; via tele nitrogen SRHMM037847-1 H Nickel; via tele nitrogen SRHMM037847-1 [ED] Nickel SRHMM037847-1 H Nickel; via tele nitrogen 1 PIRSR037861-1 Domain

PIRSF037861 Eukaryota

SRHMM037861-1 N Glutathione H Glutathione R-V Glutathione binding E-S Glutathione binding 1 PIRSR037875-50 Domain

PIRSF037875 Bacilli

SRHMM037875-50 D Charge relay system H Charge relay system S Charge relay system 1 PIRSR037880-1 Domain

PIRSF037880 Eukaryota

SRHMM037880-1 C 1 PIRSR037891-1 Domain

PIRSF037891 Eukaryota

SRHMM037891-1 FTGRP_1 SRHMM037891-1 FTGRP_2 SRHMM037891-1 FTGRP_3 Disulfide bond SRHMM037891-1 C-x(13)-C SRHMM037891-1 C-x(11)-C SRHMM037891-1 C-x(11)-C 1 PIRSR037907-1 Domain

PIRSF037907 Bacteria Archaea

SRHMM037907-1 D Charge relay system H Charge relay system S Nucleophile 1 PIRSR037907-2 Domain

PIRSF037907 Bacteria Archaea

SRHMM037907-2 FTGRP_1 SRHMM037907-2 FTGRP_2 SRHMM037907-2 FTGRP_3 SRHMM037907-2 FTGRP_4 SRHMM037907-2 FTGRP_5 SRHMM037907-2 FTGRP_6 SRHMM037907-2 FTGRP_7 SRHMM037907-2 FTGRP_8 SRHMM037907-2 FTGRP_9 Calcium Metal-binding SRHMM037907-2 [LI] Calcium 2; via carbonyl oxygen SRHMM037907-2 E Calcium 2 SRHMM037907-2 P Calcium 1; via carbonyl oxygen SRHMM037907-2 I Calcium 1; via carbonyl oxygen SRHMM037907-2 D Calcium 2 SRHMM037907-2 T Calcium 2; via carbonyl oxygen SRHMM037907-2 D Calcium 2 SRHMM037907-2 D Calcium 1 SRHMM037907-2 Y Calcium 1; via carbonyl oxygen 1 PIRSR037907-3 Domain

PIRSF037907 Bacteria Archaea

SRHMM037907-3 N Important for catalytic activity 1 PIRSR037911-1 Domain

PIRSF037911 Eukaryota

SRHMM037911-1 H 1 PIRSR037911-2 Domain

PIRSF037911 Eukaryota

SRHMM037911-2 FTGRP_1 SRHMM037911-2 FTGRP_2 SRHMM037911-2 FTGRP_3 SRHMM037911-2 FTGRP_4 Metal-binding Zinc SRHMM037911-2 C Zinc SRHMM037911-2 C Zinc SRHMM037911-2 H Zinc SRHMM037911-2 C Zinc 1 PIRSR037911-3 Domain

PIRSF037911 Eukaryota

SRHMM037911-3 H Contributes to catalysis 1 PIRSR037913-1 Domain

PIRSF037913 Eukaryota

SRHMM037913-1 H Proton acceptor 1 PIRSR037913-2 Domain

PIRSF037913 Eukaryota

SRHMM037913-2 D Substrate G Substrate; via carbonyl oxygen Y Substrate 1 PIRSR037913-3 Domain

PIRSF037913 Eukaryota

SRHMM037913-3 FTGRP_1 SRHMM037913-3 FTGRP_2 SRHMM037913-3 FTGRP_3 Metal-binding SRHMM037913-3 D Divalent metal cation SRHMM037913-3 H Divalent metal cation SRHMM037913-3 D Divalent metal cation 1 PIRSR037921-1 Domain

PIRSF037921 Eukaryota

SRHMM037921-1 D Proton acceptor 1 PIRSR037921-2 Domain

PIRSF037921 Eukaryota

SRHMM037921-2 FTGRP_1 SRHMM037921-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM037921-2 K ATP SRHMM037921-2 [LI]-x(7)-V ATP 1 PIRSR037932-1 Domain

PIRSF037932 Eukaryota

SRHMM037932-1 FTGRP_1 RNA-binding SRHMM037932-1 R Interaction with RNA F Interaction with RNA R Interaction with RNA N Interaction with RNA K Interaction with RNA F Interaction with RNA R Interaction with RNA R Interaction with RNA 1 PIRSR037933-1 Domain

PIRSF037933 Eukaryota

SRHMM037933-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR037935-1 Domain

PIRSF037935 Eukaryota

SRHMM037935-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR037938-1 Domain

PIRSF037938 Eukaryota

SRHMM037938-1 H Proton acceptor 1 PIRSR037938-2 Domain

PIRSF037938 Eukaryota

SRHMM037938-2 FTGRP_1 SRHMM037938-2 FTGRP_2 SRHMM037938-2 FTGRP_3 SRHMM037938-2 FTGRP_4 SRHMM037938-2 FTGRP_5 SRHMM037938-2 FTGRP_6 NAD SRHMM037938-2 A-x(3)-T NAD SRHMM037938-2 T-S NAD SRHMM037938-2 D-x-R NAD SRHMM037938-2 N-x-[ED] NAD SRHMM037938-2 C NAD; via amide nitrogen SRHMM037938-2 Q-x(2)-D NAD 1 PIRSR037938-3 Domain

PIRSF037938 Eukaryota

SRHMM037938-3 FTGRP_1 SRHMM037938-3 FTGRP_2 SRHMM037938-3 FTGRP_3 SRHMM037938-3 FTGRP_4 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM037938-3 C Zinc SRHMM037938-3 C Zinc SRHMM037938-3 C Zinc SRHMM037938-3 C Zinc 1 PIRSR037941-1 Domain

PIRSF037941 Eukaryota

SRHMM037941-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR037942-1 Domain

PIRSF037942 Eukaryota

SRHMM037942-1 K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) 1 PIRSR037945-1 Domain

PIRSF037945 Eukaryota

SRHMM037945-1 FTGRP_1 Disulfide bond SRHMM037945-1 C-x(5)-C SRHMM037945-1 C-x(123)-C 1 PIRSR037947-1 Domain

PIRSF037947 Eukaryota

SRHMM037947-1 FTGRP_1 SRHMM037947-1 FTGRP_2 GTP-binding Nucleotide-binding SRHMM037947-1 G-S GTP SRHMM037947-1 Q-x(2)-R GTP 1 PIRSR037947-2 Domain

PIRSF037947 Eukaryota

SRHMM037947-2 G N-myristoyl glycine C S-palmitoyl cysteine 1 PIRSR037955-1 Domain

PIRSF037955 Eukaryota

SRHMM037955-1 K Interaction with m3G-cap structure SRHMM037955-1 S Interaction with m3G-cap structure SRHMM037955-1 W Interaction with m3G-cap structure 1 PIRSR037993-1 Domain

PIRSF037993 Eukaryota

SRHMM037993-1 D Proton acceptor 1 PIRSR037993-2 Domain

PIRSF037993 Eukaryota

SRHMM037993-2 FTGRP_1 SRHMM037993-2 FTGRP_2 SRHMM037993-2 FTGRP_3 SRHMM037993-2 FTGRP_4 ATP-binding SRHMM037993-2 D ATP SRHMM037993-2 L-x(7)-V ATP SRHMM037993-2 K ATP SRHMM037993-2 E ATP; via carbonyl oxygen 1 PIRSR038013-50 Domain

PIRSF038013 Chordata

SRHMM038013-50 FTGRP_1 Metal-binding Zinc SRHMM038013-50 C Zinc 1 PIRSR038023-1 Domain

PIRSF038023 Eukaryota

SRHMM038023-1 FTGRP_1 SRHMM038023-1 FTGRP_2 SRHMM038023-1 FTGRP_3 Metal-binding SRHMM038023-1 S Divalent metal cation SRHMM038023-1 T Divalent metal cation SRHMM038023-1 S Divalent metal cation 1 PIRSR038023-2 Domain

PIRSF038023 Eukaryota

SRHMM038023-2 FTGRP_1 Disulfide bond SRHMM038023-2 C-x(178)-C 1 PIRSR038025-50 Domain

PIRSF038025 Chordata

SRHMM038025-50 C Phosphocysteine intermediate 1 PIRSR038051-1 Domain

PIRSF038051 Eukaryota

SRHMM038051-1 FTGRP_1 SRHMM038051-1 FTGRP_2 SRHMM038051-1 FTGRP_3 SRHMM038051-1 FTGRP_4 SRHMM038051-1 FTGRP_5 SRHMM038051-1 FTGRP_6 FAD FAD SRHMM038051-1 V-x(7)-S-x(18)-E-A FAD SRHMM038051-1 T-V FAD SRHMM038051-1 M-V FAD SRHMM038051-1 E FAD SRHMM038051-1 R FAD SRHMM038051-1 R FAD 1 PIRSR038061-1 Domain

PIRSF038061 Eukaryota

SRHMM038061-1 N-x-[ST] N-linked (GlcNAc...) asparagine 1 PIRSR038065-1 Domain

PIRSF038065 Eukaryota

SRHMM038065-1 C Involved in dimerization 1 PIRSR038065-2 Domain

PIRSF038065 Eukaryota

SRHMM038065-2 FTGRP_1 SRHMM038065-2 FTGRP_2 SRHMM038065-2 FTGRP_3 SRHMM038065-2 FTGRP_4 SRHMM038065-2 FTGRP_5 SRHMM038065-2 FTGRP_6 SRHMM038065-2 FTGRP_7 SRHMM038065-2 FTGRP_8 SRHMM038065-2 FTGRP_9 Disulfide bond SRHMM038065-2 C-x(12)-C SRHMM038065-2 C-x(17)-C SRHMM038065-2 C-x(18)-C SRHMM038065-2 C-x(17)-C SRHMM038065-2 C-x(10)-C SRHMM038065-2 C-x(14)-C SRHMM038065-2 C-x(17)-C SRHMM038065-2 C-x(13)-C SRHMM038065-2 C-x(14)-C 1 PIRSR038073-1 Domain

PIRSF038073 Eukaryota

SRHMM038073-1 D 1 PIRSR038073-2 Domain

PIRSF038073 Eukaryota

SRHMM038073-2 R Substrate D Substrate 1 PIRSR038073-3 Domain

PIRSF038073 Eukaryota

SRHMM038073-3 FTGRP_1 SRHMM038073-3 FTGRP_2 Manganese Metal-binding Mn(2+) SRHMM038073-3 H Manganese SRHMM038073-3 D Manganese 1 PIRSR038079-1 Domain

PIRSF038079 Eukaryota

SRHMM038079-1 FTGRP_1 ATP-binding Nucleotide-binding SRHMM038079-1 G-x(6)-[NST] ATP 1 PIRSR038084-1 Domain

PIRSF038084 Eukaryota

SRHMM038084-1 E Proton donor/acceptor 1 PIRSR038084-2 Domain

PIRSF038084 Eukaryota

SRHMM038084-2 [FY]-x-I Acetyl-CoA binding SRHMM038084-2 Q-x(5)-[ST] Acetyl-CoA binding SRHMM038084-2 Y-x-[YFW] Interaction with histone H4 N-terminus SRHMM038084-2 N Acetyl-CoA SRHMM038084-2 [DE]-x-E Interaction with histone H4 N-terminus SRHMM038084-2 R Acetyl-CoA 1 PIRSR038084-3 Domain

PIRSF038084 Eukaryota

SRHMM038084-3 W Interaction with histone H4 N-terminus 1 PIRSR038085-1 Domain

PIRSF038085 Eukaryota

SRHMM038085-1 FTGRP_1 SRHMM038085-1 FTGRP_2 SRHMM038085-1 FTGRP_3 Metal-binding Zinc SRHMM038085-1 H Zinc SRHMM038085-1 H Zinc SRHMM038085-1 D Zinc 1 PIRSR038085-2 Domain

PIRSF038085 Eukaryota

SRHMM038085-2 FTGRP_1 SRHMM038085-2 FTGRP_2 SRHMM038085-2 FTGRP_3 Disulfide bond SRHMM038085-2 C-x(34)-C SRHMM038085-2 C-x(4)-C SRHMM038085-2 C-x(42)-C 1 PIRSR038096-1 Domain

PIRSF038096 Eukaryota

SRHMM038096-1 FTGRP_1 Phosphorylated by ABL2/ARG in response to oxidative stress. SRHMM038096-1 Y Phosphotyrosine; by ABL2 1 PIRSR038120-1 Domain

PIRSF038120 Eukaryota

SRHMM038120-1 C Nucleophile H Proton donor 1 PIRSR038120-2 Domain

PIRSF038120 Eukaryota

SRHMM038120-2 D Important for enzyme activity 1 PIRSR038128-50 Domain

PIRSF038128 Spermatophyta

SRHMM038128-50 S Nucleophile D Charge relay system H Charge relay system 1 PIRSR038134-1 Domain

PIRSF038134 Eukaryota

SRHMM038134-1 FTGRP_1 SRHMM038134-1 FTGRP_2 SRHMM038134-1 FTGRP_3 SRHMM038134-1 FTGRP_4 Nucleotide-binding SRHMM038134-1 E-N GTP SRHMM038134-1 H GTP; via amide nitrogen SRHMM038134-1 S-x(4)-E GTP SRHMM038134-1 G-x(4)-S GTP 1 PIRSR038134-2 Domain

PIRSF038134 Eukaryota

SRHMM038134-2 FTGRP_1 SRHMM038134-2 FTGRP_2 Magnesium Metal-binding SRHMM038134-2 Q Magnesium SRHMM038134-2 S Magnesium 1 PIRSR038142-1 Domain

PIRSF038142 Bacteria

SRHMM038142-1 D Primary proton acceptor L Responsible for spectral tuning E Primary proton donor 1 PIRSR038142-50 Domain This rule was created based on analysis for RESID:AA0120. The UniProtKB entry with the shared homology domain and experimental information is P02699.

PIRSF038142 Bacteria

SRHMM038142-50 FTGRP_1 Chromophore Retinal protein Contains one covalently linked retinal chromophore. SRHMM038142-50 K N6-(retinylidene)lysine 1 PIRSR038147-1 Domain

PIRSF038147 Eukaryota

SRHMM038147-1 D Proton acceptor D 4-aspartylphosphate intermediate 1 PIRSR038147-2 Domain

PIRSF038147 Eukaryota

SRHMM038147-2 FTGRP_1 SRHMM038147-2 FTGRP_2 SRHMM038147-2 FTGRP_3 ATP-binding Nucleotide-binding SRHMM038147-2 [STG] ATP; via carbonyl oxygen SRHMM038147-2 K ATP SRHMM038147-2 [IL] ATP; via amide nitrogen 1 PIRSR038147-3 Domain

PIRSF038147 Eukaryota

SRHMM038147-3 FTGRP_1 SRHMM038147-3 FTGRP_2 Mg(2+) SRHMM038147-3 N Magnesium SRHMM038147-3 D Magnesium 1 PIRSR038159-50 Domain This rule was created based on analysis for RESID:AA0102 and RESID:AA0106.

PIRSF038159 Eukaryota

SRHMM038159-50 x(3) Removed in mature form C S-palmitoyl cysteine C Cysteine methyl ester C S-farnesyl cysteine 1 PIRSR038165-50 Domain

PIRSF038165 Metazoa

SRHMM038165-50 D Proton acceptor 1 PIRSR038165-51 Domain

PIRSF038165 Metazoa

SRHMM038165-51 FTGRP_1 ATP-binding Nucleotide-binding SRHMM038165-51 [VL]-x(7)-V ATP K ATP 1 PIRSR038172-1 Domain

PIRSF038172 Eukaryota

SRHMM038172-1 D Proton acceptor 1 PIRSR038172-2 Domain

PIRSF038172 Eukaryota

SRHMM038172-2 FTGRP_1 ATP-binding Nucleotide-binding SRHMM038172-2 [LVI]-x(7)-V ATP K ATP 1 PIRSR038186-1 Domain

PIRSF038186 Eukaryota

SRHMM038186-1 FTGRP_2 ATP-binding Nucleotide-binding SRHMM038186-1 K 1D-myo-inositol 1,3,4-trisphosphate K 1D-myo-inositol 1,3,4-trisphosphate H 1D-myo-inositol 1,3,4-trisphosphate K 1D-myo-inositol 1,3,4-trisphosphate N 1D-myo-inositol 1,3,4-trisphosphate [SGCT] 1D-myo-inositol 1,3,4-trisphosphate SRHMM038186-1 R ATP K ATP Q-x(10)-K ATP S ATP 1 PIRSR038186-2 Domain

PIRSF038186 Eukaryota

SRHMM038186-2 FTGRP_1 SRHMM038186-2 FTGRP_2 SRHMM038186-2 FTGRP_3 Mg(2+) Binds 2 magnesium ions per subunit. Metal-binding Magnesium SRHMM038186-2 N Magnesium 2 SRHMM038186-2 D Magnesium 1 SRHMM038186-2 D Magnesium 1 D Magnesium 2 1 PIRSR038189-1 Domain

PIRSF038189 Eukaryota

SRHMM038189-1 D Proton acceptor 1 PIRSR038189-2 Domain

PIRSF038189 Eukaryota

SRHMM038189-2 FTGRP_1 SRHMM038189-2 FTGRP_2 SRHMM038189-2 FTGRP_3 ATP-binding Nucleotide-binding SRHMM038189-2 K ATP SRHMM038189-2 K-x-A ATP SRHMM038189-2 K ATP 1 PIRSR038193-1 Domain

PIRSF038193 Eukaryota

SRHMM038193-1 E Proton donor 1 PIRSR038193-2 Domain

PIRSF038193 Eukaryota

SRHMM038193-2 N-x-[ST] N-linked (GlcNAc...) asparagine 1 PIRSR038193-3 Domain

PIRSF038193 Eukaryota

SRHMM038193-3 FTGRP_1 SRHMM038193-3 FTGRP_2 SRHMM038193-3 FTGRP_3 SRHMM038193-3 FTGRP_4 SRHMM038193-3 FTGRP_5 Disulfide bond SRHMM038193-3 C-x(289)-C SRHMM038193-3 C-x(13)-C SRHMM038193-3 C-x(8)-C SRHMM038193-3 C-x(54)-C SRHMM038193-3 C-x(10)-C 1 PIRSR038455-1 Domain

PIRSF038455 Bacteria

SRHMM038455-1 C Cysteine persulfide intermediate 1 PIRSR038455-2 Domain

PIRSF038455 Bacteria

SRHMM038455-2 FTGRP_1 SRHMM038455-2 FTGRP_2 SRHMM038455-2 FTGRP_3 SRHMM038455-2 FTGRP_4 Heme heme Binds 2 heme groups per subunit. SRHMM038455-2 C Heme 1; covalent SRHMM038455-2 C Heme 1; covalent SRHMM038455-2 R Substrate SRHMM038455-2 C Heme 2; covalent SRHMM038455-2 C Heme 2; covalent 1 PIRSR038455-3 Domain

PIRSF038455 Bacteria

SRHMM038455-3 FTGRP_1 SRHMM038455-3 FTGRP_2 SRHMM038455-3 FTGRP_3 SRHMM038455-3 FTGRP_4 Iron Metal-binding SRHMM038455-3 H Iron (heme 1 axial ligand); via tele nitrogen SRHMM038455-3 C Iron (heme 2 axial ligand) SRHMM038455-3 C Iron (heme 1 axial ligand) SRHMM038455-3 H Iron (heme 2 axial ligand); via tele nitrogen 1 PIRSR038885-1 Domain

PIRSF038885 Eukaryota Bacteria

SRHMM038885-1 H Ubiquinone 1 PIRSR038885-2 Domain

PIRSF038885 Eukaryota Bacteria

SRHMM038885-2 FTGRP_1 SRHMM038885-2 FTGRP_2 SRHMM038885-2 FTGRP_3 SRHMM038885-2 FTGRP_4 Heme Iron Metal-binding heme Binds 2 heme groups non-covalently. SRHMM038885-2 H Iron 1 (heme b562 axial ligand) SRHMM038885-2 H Iron 1 (heme b562 axial ligand) SRHMM038885-2 H Iron 2 (heme b566 axial ligand) SRHMM038885-2 H Iron 2 (heme b566 axial ligand) 1 PIRSR038895-1 Domain

PIRSF038895 Eukaryota

SRHMM038895-1 FTGRP_1 SRHMM038895-1 FTGRP_2 ATP-binding Nucleotide-binding SRHMM038895-1 R ATP SRHMM038895-1 D ATP 1 PIRSR038895-2 Domain

PIRSF038895 Eukaryota

SRHMM038895-2 FTGRP_1 SRHMM038895-2 FTGRP_2 Magnesium Metal-binding SRHMM038895-2 E Magnesium 1 SRHMM038895-2 D Magnesium 2 SRHMM038895-2 S Magnesium 1 1 PIRSR038896-50 Domain

PIRSF038896 Eukaryota

SRHMM038896-50 Y . N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine H . N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine 1 PIRSR038925-1 Domain

PIRSF038925 Bacteria

SRHMM038925-1 FTGRP_1 SRHMM038925-1 FTGRP_2 SRHMM038925-1 FTGRP_3 SRHMM038925-1 FTGRP_4 ATP-binding Nucleotide-binding SRHMM038925-1 E ATP SRHMM038925-1 Y ATP SRHMM038925-1 H ATP SRHMM038925-1 G-x(5)-R ATP 1 PIRSR038927-1 Domain

PIRSF038927 Eukaryota Bacteria

SRHMM038927-1 H N 1 PIRSR038927-2 Domain

PIRSF038927 Eukaryota Bacteria

SRHMM038927-2 FTGRP_1 Iron Metal-binding heme SRHMM038927-2 Y Iron (heme axial ligand) 1 PIRSR038927-3 Domain

PIRSF038927 Bacteria

SRHMM038927-3 FTGRP_1 SRHMM038927-3 FTGRP_2 SRHMM038927-3 FTGRP_3 SRHMM038927-3 FTGRP_4 SRHMM038927-3 FTGRP_5 Heme heme SRHMM038927-3 F Heme SRHMM038927-3 R Heme SRHMM038927-3 R Heme SRHMM038927-3 R Heme SRHMM038927-3 R Heme 1 PIRSR038928-1 Domain

PIRSF038928 Archaea Eukaryota Bacteria

SRHMM038928-1 H N 1 PIRSR038928-2 Domain

PIRSF038928 Archaea Eukaryota Bacteria

SRHMM038928-2 FTGRP_1 Heme Iron Metal-binding heme SRHMM038928-2 Y Iron (heme axial ligand) 1 PIRSR038941-1 Domain

PIRSF038941 Bacteria

SRHMM038941-1 D Substrate SRHMM038941-1 E Substrate 1 PIRSR038945-1 Domain

PIRSF038945 Bacteria Archaea

SRHMM038945-1 FTGRP_1 SRHMM038945-1 FTGRP_2 SRHMM038945-1 FTGRP_3 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM038945-1 G-x(3)-N Pyridoxal phosphate binding SRHMM038945-1 N Pyridoxal phosphate SRHMM038945-1 T Pyridoxal phosphate 1 PIRSR038945-2 Domain

PIRSF038945 Bacteria Archaea

SRHMM038945-2 K N6-(pyridoxal phosphate)lysine 1 PIRSR038945-3 Domain

PIRSF038945 Bacteria Archaea

SRHMM038945-3 K Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) 1 PIRSR038994-1 Domain

PIRSF038994 Eukaryota Bacteria

SRHMM038994-1 D Proton donor/acceptor 1 PIRSR038994-2 Domain

PIRSF038994 Eukaryota Bacteria

SRHMM038994-2 [TAIVC] Substrate; via amide nitrogen N-[AG] Substrate binding R Substrate H Substrate; via tele nitrogen [LI]-x-G Substrate binding 1 PIRSR038994-3 Domain

PIRSF038994 Eukaryota Bacteria

SRHMM038994-3 FTGRP_1 SRHMM038994-3 FTGRP_2 SRHMM038994-3 FTGRP_3 Metal-binding a divalent metal cation Binds 1 divalent metal cation per subunit. SRHMM038994-3 H Divalent metal cation; via tele nitrogen SRHMM038994-3 H Divalent metal cation; via tele nitrogen SRHMM038994-3 E Divalent metal cation 1 PIRSR039004-1 Domain

PIRSF039004 Bacteria

SRHMM039004-1 FTGRP_1 SRHMM039004-1 FTGRP_2 SRHMM039004-1 FTGRP_3 SRHMM039004-1 FTGRP_4 SRHMM039004-1 FTGRP_5 SRHMM039004-1 FTGRP_6 SRHMM039004-1 FTGRP_7 Metal-binding Zinc SRHMM039004-1 K Zinc 2; via carbamate group SRHMM039004-1 H Zinc 2; via tele nitrogen SRHMM039004-1 H Zinc 2; via pros nitrogen SRHMM039004-1 K Zinc 1; via carbamate group SRHMM039004-1 H Zinc 1; via tele nitrogen SRHMM039004-1 H Zinc 1; via tele nitrogen SRHMM039004-1 D Zinc 1 1 PIRSR039004-2 Domain

PIRSF039004 Bacteria

SRHMM039004-2 K N6-carboxylysine 1 PIRSR039004-3 Domain

PIRSF039004 Bacteria

SRHMM039004-3 R Transition state stabilizer 1 PIRSR039020-50 Domain

PIRSF039020 Enterobacterales

SRHMM039020-50 [RT]-[YF] Phenazine antibiotic binding W Phenazine antibiotic 1 PIRSR039026-1 Domain

PIRSF039026 Bacteria

SRHMM039026-1 [QEN] Substrate R Substrate 1 PIRSR039026-2 Domain

PIRSF039026 Bacteria

SRHMM039026-2 FTGRP_1 SRHMM039026-2 FTGRP_2 SRHMM039026-2 FTGRP_3 SRHMM039026-2 FTGRP_4 Metal-binding SRHMM039026-2 [QEN] Metal cation SRHMM039026-2 [WFRLY] Metal cation; via carbonyl oxygen SRHMM039026-2 [EQD] Metal cation SRHMM039026-2 [ED] Metal cation 1 PIRSR039050-50 Domain

PIRSF039050 Metazoa

SRHMM039050-50 FTGRP_1 ATP-binding Nucleotide-binding SRHMM039050-50 D-x(4)-T ATP L-x-D ATP R ATP K ATP D-x-W ATP N-x(3)-R ATP K ATP 1 PIRSR039050-51 Domain

PIRSF039050 Metazoa

SRHMM039050-51 FTGRP_1 Magnesium Metal-binding Manganese Mg(2+) Mn(2+) Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro). SRHMM039050-51 D Magnesium 1; catalytic D Magnesium 2; catalytic I Magnesium 2; via carbonyl oxygen; catalytic D Magnesium 1; catalytic D Magnesium 2; catalytic 1 PIRSR039102-3 Domain

PIRSF039102 Bacteria

SRHMM039102-3 FTGRP_1 SRHMM039102-3 FTGRP_2 SRHMM039102-3 FTGRP_3 Magnesium Manganese Metal-binding Mg(2+) Mn(2+) Binds 2 magnesium or manganese ions per subunit. SRHMM039102-3 D Magnesium or manganese 1 SRHMM039102-3 N Magnesium or manganese 2 SRHMM039102-3 E Magnesium or manganese 1 E Magnesium or manganese 2 1 PIRSR039133-1 Domain

PIRSF039133 Eukaryota

SRHMM039133-1 C Glycyl thioester intermediate 1 PIRSR039133-2 Domain

PIRSF039133 Eukaryota

SRHMM039133-2 FTGRP_1 SRHMM039133-2 FTGRP_2 SRHMM039133-2 FTGRP_3 SRHMM039133-2 FTGRP_4 SRHMM039133-2 FTGRP_5 SRHMM039133-2 FTGRP_6 ATP-binding Nucleotide-binding SRHMM039133-2 S-I ATP SRHMM039133-2 K ATP SRHMM039133-2 G-x(4)-G ATP SRHMM039133-2 D-x(4)-R ATP SRHMM039133-2 D ATP SRHMM039133-2 N-x(2)-R ATP 1 PIRSR039133-3 Domain

PIRSF039133 Eukaryota

SRHMM039133-3 FTGRP_1 SRHMM039133-3 FTGRP_2 SRHMM039133-3 FTGRP_3 SRHMM039133-3 FTGRP_4 Metal-binding Zinc SRHMM039133-3 C Zinc SRHMM039133-3 C Zinc SRHMM039133-3 C Zinc SRHMM039133-3 C Zinc 1 PIRSR039133-4 Domain

PIRSF039133 Eukaryota

SRHMM039133-4 K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) 1 PIRSR039144-50 Domain This rule was created based on analysis for RESID:AA0256.

PIRSF039144 Bacteria

SRHMM039144-50 Y O-UMP-tyrosine 1 PIRSR500133-1 Domain

PIRSF500133 Eukaryota Bacteria

SRHMM500133-1 C Nucleophile 1 PIRSR500133-2 Domain

PIRSF500133 Eukaryota Bacteria

SRHMM500133-2 E-x(3)-E Substrate binding K-x(3)-N Substrate binding [RK] Substrate K-x(5)-G Substrate binding F-K Substrate binding R Substrate 1 PIRSR500133-3 Domain

PIRSF500133 Eukaryota Bacteria

SRHMM500133-3 FTGRP_1 SRHMM500133-3 FTGRP_2 SRHMM500133-3 FTGRP_3 SRHMM500133-3 FTGRP_4 SRHMM500133-3 FTGRP_5 SRHMM500133-3 FTGRP_6 SRHMM500133-3 FTGRP_7 SRHMM500133-3 FTGRP_8 NAD SRHMM500133-3 C-x(2)-K NAD SRHMM500133-3 S-T NAD SRHMM500133-3 D NAD SRHMM500133-3 R NAD SRHMM500133-3 E NAD SRHMM500133-3 G-x(4)-G NAD SRHMM500133-3 V-x(3)-T NAD SRHMM500133-3 [RK] NAD 1 PIRSR500134-1 Domain

PIRSF500134 Eukaryota Bacteria Archaea Viruses

SRHMM500134-1 C Nucleophile 1 PIRSR500134-2 Domain

PIRSF500134 Eukaryota Bacteria Archaea Viruses

SRHMM500134-2 F-x(2)-E Substrate binding K Substrate [YF]-x(3)-[SG] Substrate binding G Substrate; via amide nitrogen M Substrate; via carbonyl oxygen K Substrate D Substrate 1 PIRSR500134-3 Domain

PIRSF500134 Eukaryota Bacteria Archaea Viruses

SRHMM500134-3 FTGRP_1 SRHMM500134-3 FTGRP_2 SRHMM500134-3 FTGRP_3 SRHMM500134-3 FTGRP_4 SRHMM500134-3 FTGRP_5 SRHMM500134-3 FTGRP_6 SRHMM500134-3 FTGRP_7 NAD SRHMM500134-3 T NAD SRHMM500134-3 R NAD SRHMM500134-3 [KR] NAD SRHMM500134-3 K NAD SRHMM500134-3 D NAD SRHMM500134-3 T NAD; via amide nitrogen SRHMM500134-3 E NAD 1 PIRSR500135-1 Domain

PIRSF500135 Bacteria

SRHMM500135-1 C Nucleophile 1 PIRSR500135-2 Domain

PIRSF500135 Bacteria

SRHMM500135-2 E-x(3)-E Substrate binding K-x(6)-H Substrate binding Y-x(8)-G Substrate binding 1 PIRSR500135-3 Domain

PIRSF500135 Bacteria

SRHMM500135-3 FTGRP_1 SRHMM500135-3 FTGRP_2 SRHMM500135-3 FTGRP_3 SRHMM500135-3 FTGRP_4 SRHMM500135-3 FTGRP_5 SRHMM500135-3 FTGRP_6 SRHMM500135-3 FTGRP_7 SRHMM500135-3 FTGRP_8 NAD SRHMM500135-3 G-x(4)-G NAD SRHMM500135-3 D NAD SRHMM500135-3 K NAD SRHMM500135-3 T NAD; via amide nitrogen SRHMM500135-3 K NAD SRHMM500135-3 E NAD SRHMM500135-3 R NAD SRHMM500135-3 T NAD 1 PIRSR500947-50 Domain

PIRSF500947 Vertebrata

SRHMM500947-50 D Proton acceptor 1 PIRSR500947-51 Domain

PIRSF500947 Vertebrata

SRHMM500947-51 FTGRP_1 ATP-binding Nucleotide-binding SRHMM500947-51 L-x(7)-V ATP K ATP 1 PIRSR500947-52 Domain

PIRSF500947 Vertebrata

SRHMM500947-52 FTGRP_1 Disulfide bond SRHMM500947-52 C-x(41)-C C-x(49)-C C-x(53)-C C-x(65)-C 1 PIRSR500948-1 Domain

PIRSF500948 Eukaryota

SRHMM500948-1 D Proton acceptor 1 PIRSR500948-2 Domain

PIRSF500948 Eukaryota

SRHMM500948-2 FTGRP_1 SRHMM500948-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM500948-2 L-x(7)-V ATP SRHMM500948-2 K ATP 1 PIRSR500950-50 Domain

PIRSF500950 Vertebrata

SRHMM500950-50 D Proton acceptor 1 PIRSR500950-51 Domain

PIRSF500950 Vertebrata

SRHMM500950-51 FTGRP_1 ATP-binding Nucleotide-binding SRHMM500950-51 L-x(7)-V ATP K ATP 1 PIRSR500950-52 Domain

PIRSF500950 Vertebrata

SRHMM500950-52 FTGRP_1 Disulfide bond SRHMM500950-52 C-x(50)-C C-x(38)-C C-x(54)-C C-x(65)-C 1 PIRSR500951-1 Domain

PIRSF500951 Eukaryota

SRHMM500951-1 FTGRP_1 SRHMM500951-1 FTGRP_2 SRHMM500951-1 FTGRP_3 Magnesium Metal-binding SRHMM500951-1 D Magnesium SRHMM500951-1 Y Magnesium SRHMM500951-1 N Magnesium 1 PIRSR500951-2 Domain

PIRSF500951 Eukaryota

SRHMM500951-2 FTGRP_1 SRHMM500951-2 FTGRP_2 SRHMM500951-2 FTGRP_3 SRHMM500951-2 FTGRP_4 ATP-binding Nucleotide-binding SRHMM500951-2 R ATP SRHMM500951-2 E-x(5)-D ATP SRHMM500951-2 K ATP SRHMM500951-2 G-x(6)-V ATP 1 PIRSR500951-3 Domain

PIRSF500951 Eukaryota

SRHMM500951-3 Y Important for interaction with phosphotyrosine-binding proteins 1 PIRSR600223-1 Domain

IPR000223 Eukaryota Bacteria

SRHMM600223-1 S K 1 PIRSR600239-50 Domain This rule was created based on analysis for RESID:AA0105.

IPR000239 Eukaryota

SRHMM600239-50 FTGRP_1 Methylation SRHMM600239-50 C Cysteine methyl ester 1 PIRSR600239-51 Domain

IPR000239 Eukaryota

SRHMM600239-51 D Proton acceptor 1 PIRSR600243-1 Domain

IPR000243 Eukaryota Bacteria Archaea

SRHMM600243-1 T Nucleophile 1 PIRSR600246-1 Domain

IPR000246 Eukaryota Bacteria Archaea

SRHMM600246-1 T Nucleophile 1 PIRSR600246-2 Domain

IPR000246 Eukaryota Bacteria Archaea

SRHMM600246-2 R-x(2)-D Substrate binding T-x(2)-G Substrate binding 1 PIRSR600246-3 Domain

IPR000246 Eukaryota Bacteria Archaea

SRHMM600246-3 [GDES]-T Cleavage; by autolysis 1 PIRSR600250-50 Domain

IPR000250 Eukaryota Bacteria Archaea

SRHMM600250-50 E Proton acceptor 1 PIRSR600250-51 Domain

IPR000250 Eukaryota Bacteria Archaea

SRHMM600250-51 FTGRP_1 Disulfide bond SRHMM600250-51 C-x(23)-C C-x(82)-C 1 PIRSR600269-50 Domain

IPR000269 Eukaryota Bacteria

SRHMM600269-50 FTGRP_1 TPQ SRHMM600269-50 D Proton acceptor Y Schiff-base intermediate with substrate; via topaquinone 1 PIRSR600269-51 Domain This rule was created based on analysis for RESID:AA0147.

IPR000269 Eukaryota Bacteria

SRHMM600269-51 FTGRP_1 TPQ L-topaquinone Contains 1 topaquinone per subunit. Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. SRHMM600269-51 Y 2',4',5'-topaquinone 1 PIRSR600407-1 Domain

IPR000407 Eukaryota

SRHMM600407-1 E Proton acceptor 1 PIRSR600407-2 Domain

IPR000407 Eukaryota

SRHMM600407-2 FTGRP_1 ATP-binding Nucleotide-binding SRHMM600407-2 G-x(3)-Q ATP 1 PIRSR600514-1 Domain

IPR000514 Eukaryota Bacteria

SRHMM600514-1 E Proton donor 1 PIRSR600542-1 Domain

IPR000542 Eukaryota Bacteria

SRHMM600542-1 H Proton acceptor 1 PIRSR600542-2 Domain

IPR000542 Eukaryota Bacteria

SRHMM600542-2 K Coenzyme A K-x(6)-D Coenzyme A binding Y Carnitine S Carnitine S Coenzyme A; via amide nitrogen T Carnitine R Coenzyme A Q Coenzyme A; via carbonyl oxygen 1 PIRSR600821-50 Domain This rule was created based on analysis for RESID:AA0119.

IPR000821 Eukaryota Bacteria Archaea

SRHMM600821-50 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM600821-50 K N6-(pyridoxal phosphate)lysine 1 PIRSR600821-52 Domain

IPR000821 Eukaryota Bacteria Archaea

SRHMM600821-52 R Substrate M Substrate; via amide nitrogen 1 PIRSR600823-1 Domain

IPR000823 Viridiplantae

SRHMM600823-1 H Proton acceptor 1 PIRSR600823-2 Domain

IPR000823 Viridiplantae

SRHMM600823-2 P Substrate; via carbonyl oxygen 1 PIRSR600823-3 Domain

IPR000823 Viridiplantae

SRHMM600823-3 FTGRP_7 Iron heme b Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit. SRHMM600823-3 FTGRP_1 SRHMM600823-3 FTGRP_2 SRHMM600823-3 FTGRP_3 SRHMM600823-3 FTGRP_4 SRHMM600823-3 FTGRP_5 SRHMM600823-3 FTGRP_6 SRHMM600823-3 FTGRP_8 SRHMM600823-3 FTGRP_9 SRHMM600823-3 FTGRP_10 SRHMM600823-3 FTGRP_11 Calcium Ca(2+) Binds 2 calcium ions per subunit. SRHMM600823-3 FTGRP_1 SRHMM600823-3 FTGRP_2 SRHMM600823-3 FTGRP_3 SRHMM600823-3 FTGRP_4 SRHMM600823-3 FTGRP_5 SRHMM600823-3 FTGRP_6 SRHMM600823-3 FTGRP_7 SRHMM600823-3 FTGRP_8 SRHMM600823-3 FTGRP_9 SRHMM600823-3 FTGRP_10 SRHMM600823-3 FTGRP_11 Metal-binding SRHMM600823-3 D Calcium 2 SRHMM600823-3 D Calcium 1 SRHMM600823-3 T Calcium 2 SRHMM600823-3 D Calcium 2 SRHMM600823-3 G Calcium 1; via carbonyl oxygen SRHMM600823-3 D Calcium 1 SRHMM600823-3 S Calcium 1 SRHMM600823-3 T Calcium 2 SRHMM600823-3 E Calcium 1 SRHMM600823-3 V Calcium 1; via carbonyl oxygen SRHMM600823-3 H Iron (heme axial ligand) 1 PIRSR600823-4 Domain

IPR000823 Viridiplantae

SRHMM600823-4 R Transition state stabilizer 1 PIRSR600823-5 Domain

IPR000823 Viridiplantae

SRHMM600823-5 FTGRP_1 SRHMM600823-5 FTGRP_2 SRHMM600823-5 FTGRP_3 SRHMM600823-5 FTGRP_4 Disulfide bond SRHMM600823-5 C-x(79)-C SRHMM600823-5 C-x(4)-C SRHMM600823-5 C-x(31)-C SRHMM600823-5 C-x(203)-C 1 PIRSR600877-50 Domain

IPR000877 Viridiplantae

SRHMM600877-50 [RK]-S Reactive bond [YLKR]-S Reactive bond 1 PIRSR600877-51 Domain

IPR000877 Viridiplantae

SRHMM600877-51 FTGRP_1 Disulfide bond SRHMM600877-51 C-x(52)-C C-x(14)-C C-x(44)-C C-x(7)-C C-x(6)-C C-x(14)-C C-x(7)-C 1 PIRSR600888-1 Domain

IPR000888 Bacteria Archaea

SRHMM600888-1 H Proton acceptor Y Proton donor 1 PIRSR600888-2 Domain

IPR000888 Bacteria Archaea

SRHMM600888-2 R Substrate [ED] Substrate Q-x-N Substrate binding R Substrate K Substrate [HR] Substrate [ED] Substrate [KR] Substrate 1 PIRSR600888-3 Domain

IPR000888 Bacteria Archaea

SRHMM600888-3 [YWF] Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose 1 PIRSR600917-51 Domain This rule was created based on analysis for RESID:AA0185.

IPR000917 Eukaryota Bacteria Archaea

SRHMM600917-51 FTGRP_1 The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. SRHMM600917-51 C 3-oxoalanine (Cys) 1 PIRSR600917-52 Domain This rule was created based on analysis for RESID:AA0185.

IPR000917 Eukaryota Bacteria Archaea

SRHMM600917-52 FTGRP_1 The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. SRHMM600917-52 S 3-oxoalanine (Ser) 1 PIRSR600936-1 Domain

IPR000936 Viruses

SRHMM600936-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR600983-52 Domain

IPR000983 Pseudomonadales

SRHMM600983-52 FTGRP_1 Disulfide bond SRHMM600983-52 C-x(18)-C 1 PIRSR600990-50 Domain This rule was created based on analysis for RESID:AA0230.

IPR000990 Metazoa

SRHMM600990-50 FTGRP_1 S-nitrosylation S-nitrosylation inhibits channel currents and ATP release. SRHMM600990-50 C S-nitrosocysteine C S-nitrosocysteine 1 PIRSR600990-51 Domain This rule was created based on analysis for RESID:AA0151.

IPR000990 Metazoa

SRHMM600990-51 FTGRP_1 Glycoprotein SRHMM600990-51 N N-linked (GlcNAc...) asparagine 1 PIRSR600990-52 Domain This rule was created based on analysis for RESID:AA0151.

IPR000990 Metazoa

SRHMM600990-52 FTGRP_1 Glycoprotein SRHMM600990-52 N N-linked (GlcNAc...) asparagine 1 PIRSR600997-1 Domain

IPR000997 Eukaryota Bacteria

SRHMM600997-1 S Acyl-ester intermediate E Charge relay system H Charge relay system 1 PIRSR601191-1 Domain

IPR001191 Viruses

SRHMM601191-1 Y For DNA cleavage activity 1 PIRSR601191-2 Domain

IPR001191 Viruses

SRHMM601191-2 FTGRP_1 SRHMM601191-2 FTGRP_2 SRHMM601191-2 FTGRP_3 SRHMM601191-2 FTGRP_4 Metal-binding Mg(2+) Mn(2+) Divalent metal cations, possibly Mg(2+) or Mn(2+). SRHMM601191-2 H Divalent metal cation SRHMM601191-2 [DE] Divalent metal cation SRHMM601191-2 H Divalent metal cation SRHMM601191-2 E Divalent metal cation 1 PIRSR601233-1 Domain

IPR001233 Eukaryota Bacteria Archaea

SRHMM601233-1 H GMP-histidine intermediate 1 PIRSR601233-2 Domain

IPR001233 Eukaryota Bacteria Archaea

SRHMM601233-2 FTGRP_1 SRHMM601233-2 FTGRP_2 SRHMM601233-2 FTGRP_3 SRHMM601233-2 FTGRP_4 SRHMM601233-2 FTGRP_5 SRHMM601233-2 FTGRP_6 GTP-binding Nucleotide-binding SRHMM601233-2 H-N GMP SRHMM601233-2 S GMP SRHMM601233-2 H-x(2)-G GMP SRHMM601233-2 [PG]-x(2)-M GMP SRHMM601233-2 K GMP SRHMM601233-2 N-x(3)-E GMP 1 PIRSR601233-3 Domain

IPR001233 Eukaryota Bacteria Archaea

SRHMM601233-3 FTGRP_1 SRHMM601233-3 FTGRP_2 SRHMM601233-3 FTGRP_3 SRHMM601233-3 FTGRP_4 Manganese Metal-binding Mn(2+) Binds 2 manganese ions per subunit. SRHMM601233-3 H Manganese 1 SRHMM601233-3 H Manganese 2 SRHMM601233-3 D Manganese 1 SRHMM601233-3 H Manganese 2 1 PIRSR601286-50 Domain

IPR001286 Eukaryota

SRHMM601286-50 E Proton donor/acceptor E Nucleophile 1 PIRSR601465-50 Domain

IPR001465 Eukaryota Bacteria

SRHMM601465-50 R Proton acceptor D Proton donor 1 PIRSR601559-50 Domain This rule was created based on analysis for RESID:AA0114.

IPR001559 Eukaryota Bacteria Archaea

SRHMM601559-50 K N6-carboxylysine 1 PIRSR601559-51 Domain This rule was created based on analysis for RESID:AA0114.

IPR001559 Eukaryota Bacteria Archaea

SRHMM601559-51 FTGRP_1 Metal-binding a divalent metal cation Binds 2 divalent metal cations per subunit. SRHMM601559-51 H Divalent metal cation 1; via tele nitrogen H Divalent metal cation 1; via tele nitrogen K Divalent metal cation 1; via carbamate group K Divalent metal cation 2; via carbamate group H Divalent metal cation 2; via pros nitrogen H Divalent metal cation 2; via tele nitrogen D Divalent metal cation 1 1 PIRSR601559-52 Domain

IPR001559 Eukaryota Bacteria Archaea

SRHMM601559-52 FTGRP_1 Metal-binding a divalent metal cation Binds 2 divalent metal cations per subunit. SRHMM601559-52 H Divalent metal cation 1; via tele nitrogen H Divalent metal cation 1; via tele nitrogen E Divalent metal cation 1 E Divalent metal cation 2 H Divalent metal cation 2; via pros nitrogen H Divalent metal cation 2; via tele nitrogen D Divalent metal cation 1 1 PIRSR601621-1 Domain

IPR001621 Eukaryota

SRHMM601621-1 H Proton acceptor 1 PIRSR601621-2 Domain

IPR001621 Eukaryota

SRHMM601621-2 FTGRP_5 Heme Iron Metal-binding heme b Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit. SRHMM601621-2 FTGRP_1 SRHMM601621-2 FTGRP_2 SRHMM601621-2 FTGRP_3 SRHMM601621-2 FTGRP_4 SRHMM601621-2 FTGRP_6 SRHMM601621-2 FTGRP_7 SRHMM601621-2 FTGRP_8 SRHMM601621-2 FTGRP_9 Calcium Metal-binding Ca(2+) Binds 2 calcium ions per subunit. SRHMM601621-2 S Calcium 1 SRHMM601621-2 [ST] Calcium 2 SRHMM601621-2 G Calcium 1; via carbonyl oxygen SRHMM601621-2 D Calcium 2 SRHMM601621-2 T Calcium 2 SRHMM601621-2 H Iron (heme axial ligand) SRHMM601621-2 D Calcium 1 SRHMM601621-2 D Calcium 2 SRHMM601621-2 D Calcium 1 1 PIRSR601621-3 Domain

IPR001621 Eukaryota

SRHMM601621-3 R Transition state stabilizer 1 PIRSR601621-4 Domain

IPR001621 Eukaryota

SRHMM601621-4 FTGRP_1 SRHMM601621-4 FTGRP_2 SRHMM601621-4 FTGRP_3 SRHMM601621-4 FTGRP_4 Disulfide bond SRHMM601621-4 C-x(11)-C SRHMM601621-4 C-x(83)-C SRHMM601621-4 C-x(274)-C SRHMM601621-4 C-x(65)-C 1 PIRSR601681-50 Domain

IPR001681 Chordata

SRHMM601681-50 FTGRP_1 Disulfide bond SRHMM601681-50 C-x(74)-C 1 PIRSR602129-50 Domain This rule was created based on analysis for RESID:AA0119.

IPR002129 Eukaryota Bacteria Archaea

SRHMM602129-50 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM602129-50 K N6-(pyridoxal phosphate)lysine 1 PIRSR602137-50 Domain This rule was created based on analysis for RESID:AA0114.

IPR002137 Bacteria

SRHMM602137-50 S Acyl-ester intermediate K N6-carboxylysine 1 PIRSR602187-50 Domain This rule was created based on analysis for RESID:AA0256.

IPR002187 Eukaryota Bacteria Archaea

SRHMM602187-50 FTGRP_1 Phosphoprotein SRHMM602187-50 Y O-UMP-tyrosine 1 PIRSR602325-50 Domain This rule was created based on analysis for RESID:AA0134.

IPR002325 Eukaryota Bacteria

SRHMM602325-50 FTGRP_1 Heme Iron Metal-binding heme Binds 1 heme group covalently. SRHMM602325-50 [YFW] Iron (heme axial ligand); via amino nitrogen C Heme (covalent) C Heme (covalent) H Iron (heme axial ligand) 1 PIRSR602506-51 Domain This rule was created based on analysis for RESID:AA0105.

IPR002506 Viruses

SRHMM602506-51 C Cysteine methyl ester; by host 1 PIRSR602506-52 Domain This rule was created based on analysis for RESID:AA0102.

IPR002506 Viruses

SRHMM602506-52 FTGRP_1 Lipoprotein Prenylation Prenylated by host farnesyl-transferase in the cytoplasm prior to nucleus translocation. SRHMM602506-52 C S-farnesyl cysteine; by host 1 PIRSR602717-51 Domain

IPR002717 Eukaryota

SRHMM602717-51 E Proton donor/acceptor 1 PIRSR603051-50 Domain

IPR003051 Chordata

SRHMM603051-50 FTGRP_1 Disulfide bond SRHMM603051-50 C-x(23)-C C-x(42)-C C-x(33)-C C-x(69)-C 1 PIRSR603437-50 Domain This rule was created based on analysis for RESID:AA0119.

IPR003437 Eukaryota Bacteria

SRHMM603437-50 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM603437-50 K N6-(pyridoxal phosphate)lysine 1 PIRSR603739-50 Domain This rule was created based on analysis for RESID:AA0119.

IPR003739 Bacteria Archaea

SRHMM603739-50 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM603739-50 K N6-(pyridoxal phosphate)lysine 1 PIRSR603912-52 Domain

IPR003912 Vertebrata

SRHMM603912-52 FTGRP_1 Disulfide bond SRHMM603912-52 C-x(77)-C 1 PIRSR604061-50 Domain

IPR004061 Vertebrata

SRHMM604061-50 FTGRP_1 Disulfide bond SRHMM604061-50 C-x(6)-C C-x(4)-C 1 PIRSR604241-50 Domain This rule was created based on analysis for RESID:AA0346.

IPR004241 Eukaryota

SRHMM604241-50 FTGRP_1 Lipoprotein SRHMM604241-50 G Phosphatidylethanolamine amidated glycine 1 PIRSR604329-50 Domain

IPR004329 Bacteria

SRHMM604329-50 FTGRP_1 Heme Iron Metal-binding SRHMM604329-50 H Heme (covalent; via pros nitrogen) Y Iron (heme axial ligand) 1 PIRSR604450-51 Domain This rule was created based on analysis for RESID:AA0119.

IPR004450 Eukaryota Bacteria Archaea

SRHMM604450-51 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM604450-51 K N6-(pyridoxal phosphate)lysine 1 PIRSR604550-50 Domain This rule was created based on analysis for RESID:AA0525.

IPR004550 Eukaryota Bacteria

SRHMM604550-50 T Acyl-ester intermediate 1 PIRSR604677-50 Domain

IPR004677 Bacteria

SRHMM604677-50 FTGRP_1 Heme Iron Metal-binding Cu(2+) Binds 1 copper ion per subunit, denoted as copper B. heme Binds 2 heme groups per subunit, denoted as high- and low-spin. SRHMM604677-50 H Iron (low-spin heme axial ligand); via tele nitrogen H Copper B; via pros nitrogen H Copper B; via tele nitrogen H Copper B; via tele nitrogen H Iron (high-spin heme axial ligand); via tele nitrogen H Iron (low-spin heme axial ligand); via tele nitrogen 1 PIRSR604723-51 Domain This rule was created based on analysis for RESID:AA0119.

IPR004723 Bacteria Archaea

SRHMM604723-51 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM604723-51 K N6-(pyridoxal phosphate)lysine 1 PIRSR604809-50 Domain This rule was created based on analysis for RESID:AA0203.

IPR004809 Bacteria Archaea

SRHMM604809-50 FTGRP_1 Phosphoprotein SRHMM604809-50 Y O-AMP-tyrosine 1 PIRSR605212-50 Domain

IPR005212 Bacteria

SRHMM605212-50 W dTDP-sugar (pocket A) Q-x(5)-Y dTDP-sugar binding (pocket A) S dTDP-sugar (pocket B) [ND] dTDP-sugar (pocket A) W dTDP-sugar (pocket B) [RK] dTDP-sugar (pocket B) Q-x-[TSRN] dTDP-sugar binding (pocket B) N-Y dTDP-sugar binding (pocket B) E-x(2)-R dTDP-sugar binding (pocket A) 1 PIRSR605428-50 Domain

IPR005428 Mammalia

SRHMM605428-50 Y Critical for TLR4-TLR6 dimerization and signaling 1 PIRSR605428-51 Domain

IPR005428 Mammalia

SRHMM605428-51 FTGRP_1 SRHMM605428-51 FTGRP_2 Ubl conjugation Isopeptide bond SRHMM605428-51 K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) SRHMM605428-51 K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) 1 PIRSR605428-52 Domain

IPR005428 Metazoa

SRHMM605428-52 FTGRP_1 Disulfide bond SRHMM605428-52 C-x(67)-C C-x(60)-C C-x(8)-C 1 PIRSR605428-53 Domain

IPR005428 Metazoa

SRHMM605428-53 FTGRP_1 Disulfide bond SRHMM605428-53 C-x(132)-C 1 PIRSR605437-50 Domain

IPR005437 Chordata

SRHMM605437-50 FTGRP_1 Disulfide bond SRHMM605437-50 C-x(13)-C 1 PIRSR605468-50 Domain

IPR005468 Bacteria

SRHMM605468-50 FTGRP_1 Biotin SRHMM605468-50 Y Biotin Y Biotin W Biotin W Biotin W Biotin 1 PIRSR605468-51 Domain

IPR005468 Metazoa

SRHMM605468-51 FTGRP_1 Disulfide bond SRHMM605468-51 C-x(78)-C 1 PIRSR605626-50 Domain This rule was created based on analysis for RESID:AA0323.

IPR005626 Eukaryota

SRHMM605626-50 Y O-(3'-phospho-DNA)-tyrosine intermediate 1 PIRSR605792-51 Domain This rule was created based on analysis for RESID:AA0025.

IPR005792 Eukaryota

SRHMM605792-51 FTGRP_1 Disulfide bond Redox-active center SRHMM605792-51 C-x(2)-C Redox-active C-x(2)-C Redox-active 1 PIRSR605856-50 Domain

IPR005856 Eukaryota Bacteria

SRHMM605856-50 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM605856-50 N Pyridoxal phosphate G-x(3)-T Pyridoxal phosphate binding S Pyridoxal phosphate 1 PIRSR605856-51 Domain This rule was created based on analysis for RESID:AA0119.

IPR005856 Eukaryota Bacteria

SRHMM605856-51 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM605856-51 K N6-(pyridoxal phosphate)lysine 1 PIRSR605977-50 Domain This rule was created based on analysis for RESID:AA0168.

IPR005977 Bacteria Archaea

SRHMM605977-50 FTGRP_1 ADP-ribosylation The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity. SRHMM605977-50 R ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase 1 PIRSR606118-50 Domain This rule was created based on analysis for RESID:AA0246.

IPR006118 Bacteria Viruses

SRHMM606118-50 S O-(5'-phospho-DNA)-serine intermediate 1 PIRSR606225-1 Domain

IPR006225 Eukaryota Bacteria

SRHMM606225-1 D 1 PIRSR606285-1 Domain

IPR006285 Eukaryota

SRHMM606285-1 C Glycyl thioester intermediate 1 PIRSR606710-1 Domain

IPR006710 Eukaryota Bacteria

SRHMM606710-1 D Proton acceptor E Proton donor 1 PIRSR606710-2 Domain

IPR006710 Eukaryota Bacteria

SRHMM606710-2 D Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate 1 PIRSR607702-1 Domain

IPR007702 Eukaryota

SRHMM607702-1 H Proton acceptor 1 PIRSR607702-2 Domain

IPR007702 Eukaryota

SRHMM607702-2 [KR] Substrate 1 PIRSR607724-1 Domain

IPR007724 Eukaryota

SRHMM607724-1 D E E 1 PIRSR607724-2 Domain

IPR007724 Eukaryota

SRHMM607724-2 N Substrate Q Substrate; via amide nitrogen Y Substrate 1 PIRSR608127-51 Domain

IPR008127 Vertebrata

SRHMM608127-51 L Important for obstruction of the ion pore in the closed conformation 1 PIRSR608127-52 Domain

IPR008127 Vertebrata

SRHMM608127-52 FTGRP_1 Disulfide bond SRHMM608127-52 C-x(13)-C C-x(10)-C 1 PIRSR608127-53 Domain

IPR008127 Vertebrata

SRHMM608127-53 Y-x(4)-F Strychnine-binding 1 PIRSR608256-1 Domain

IPR008256 Bacteria

SRHMM608256-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR608356-50 Domain

IPR008356 Eukaryota

SRHMM608356-50 C Phosphocysteine intermediate 1 PIRSR608356-51 Domain

IPR008356 Eukaryota

SRHMM608356-51 D Substrate C-x(5)-R Substrate binding Q Substrate 1 PIRSR608734-50 Domain This rule was created based on analysis for RESID:AA0102.

IPR008734 Eukaryota

SRHMM608734-50 FTGRP_1 Lipoprotein Prenylation Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated. SRHMM608734-50 C S-farnesyl cysteine 1 PIRSR609451-50 Domain

IPR009451 Bacteria

SRHMM609451-50 FTGRP_1 Disulfide bond SRHMM609451-50 C-x(16)-C 1 PIRSR609662-50 Domain This rule was created based on analysis for RESID:AA0167.

IPR009662 Bacteria

SRHMM609662-50 FTGRP_1 Phosphoprotein Covalently binds the prosthetic group of malonate decarboxylase. SRHMM609662-50 S O-(phosphoribosyl dephospho-coenzyme A)serine 1 PIRSR610059-50 Domain

IPR010059 Eukaryota

SRHMM610059-50 R Phosphate R-x(2)-T Phosphate binding Q Substrate R Substrate 1 PIRSR610059-51 Domain

IPR010059 Eukaryota

SRHMM610059-51 FTGRP_1 Disulfide bond SRHMM610059-51 C-x(6)-C Redox-active 1 PIRSR610300-50 Domain This rule was created based on analysis for RESID:AA0113.

IPR010300 Eukaryota Bacteria

SRHMM610300-50 FTGRP_1 Thioether bond SRHMM610300-50 C-x(63)-Y 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) 1 PIRSR610300-51 Domain

IPR010300 Eukaryota Bacteria

SRHMM610300-51 FTGRP_1 Iron Metal-binding SRHMM610300-51 H Iron; via tele nitrogen; catalytic H Iron; via tele nitrogen; catalytic H Iron; via tele nitrogen; catalytic 1 PIRSR611166-50 Domain This rule was created based on analysis for RESID:AA0119.

IPR011166 Bacteria

SRHMM611166-50 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM611166-50 K N6-(pyridoxal phosphate)lysine 1 PIRSR611612-50 Domain This rule was created based on analysis for RESID:AA0114.

IPR011612 Eukaryota Bacteria Archaea

SRHMM611612-50 FTGRP_1 Carbamylation allows a single lysine to coordinate two nickel ions. SRHMM611612-50 K N6-carboxylysine 1 PIRSR611612-51 Domain This rule was created based on analysis for RESID:AA0114.

IPR011612 Eukaryota Bacteria Archaea

SRHMM611612-51 FTGRP_1 Metal-binding Nickel Ni cation Binds 2 nickel ions per subunit. SRHMM611612-51 H Nickel 1; via tele nitrogen H Nickel 1; via tele nitrogen K Nickel 1; via carbamate group K Nickel 2; via carbamate group H Nickel 2; via pros nitrogen H Nickel 2; via tele nitrogen D Nickel 1 1 PIRSR611612-52 Domain

IPR011612 Eukaryota Bacteria Archaea

SRHMM611612-52 H Proton donor 1 PIRSR611778-50 Domain This rule was created based on analysis for RESID:AA0114.

IPR011778 Eukaryota Bacteria

SRHMM611778-50 FTGRP_1 Carbamylation allows a single lysine to coordinate two divalent metal cations. SRHMM611778-50 K N6-carboxylysine 1 PIRSR613307-50 Domain

IPR013307 Firmicutes

SRHMM613307-50 FTGRP_1 Disulfide bond SRHMM613307-50 C-x(9)-C 1 PIRSR614186-1 Domain

IPR014186 Eukaryota Bacteria

SRHMM614186-1 S Charge relay system D Charge relay system H Charge relay system 1 PIRSR617453-50 Domain This rule was created based on analysis for RESID:AA0118.

IPR017453 Eukaryota Bacteria Archaea

SRHMM617453-50 FTGRP_1 Lipoyl SRHMM617453-50 K N6-lipoyllysine 1 PIRSR617512-1 Domain

IPR017512 Proteobacteria

SRHMM617512-1 D Proton acceptor 1 PIRSR617512-2 Domain

IPR017512 Proteobacteria

SRHMM617512-2 FTGRP_9 SRHMM617512-2 FTGRP_10 Heme SRHMM617512-2 FTGRP_1 SRHMM617512-2 FTGRP_2 SRHMM617512-2 FTGRP_3 SRHMM617512-2 FTGRP_4 SRHMM617512-2 FTGRP_5 SRHMM617512-2 FTGRP_6 SRHMM617512-2 FTGRP_7 SRHMM617512-2 FTGRP_8 PQQ SRHMM617512-2 R Pyrroloquinoline quinone SRHMM617512-2 N-W Pyrroloquinoline quinone binding SRHMM617512-2 G-A Pyrroloquinoline quinone binding SRHMM617512-2 C Heme c; covalent SRHMM617512-2 T Pyrroloquinoline quinone SRHMM617512-2 [VI] Pyrroloquinoline quinone; via amide nitrogen SRHMM617512-2 E Pyrroloquinoline quinone SRHMM617512-2 K Pyrroloquinoline quinone SRHMM617512-2 T Pyrroloquinoline quinone SRHMM617512-2 C Heme c; covalent 1 PIRSR617512-3 Domain

IPR017512 Proteobacteria

SRHMM617512-3 FTGRP_4 SRHMM617512-3 FTGRP_5 Iron SRHMM617512-3 FTGRP_1 SRHMM617512-3 FTGRP_2 SRHMM617512-3 FTGRP_3 Calcium SRHMM617512-3 FTGRP_1 SRHMM617512-3 FTGRP_2 SRHMM617512-3 FTGRP_3 SRHMM617512-3 FTGRP_4 SRHMM617512-3 FTGRP_5 Metal-binding SRHMM617512-3 M Iron (heme axial ligand) SRHMM617512-3 E Calcium SRHMM617512-3 H Iron (heme axial ligand); via tele nitrogen SRHMM617512-3 D Calcium SRHMM617512-3 N Calcium 1 PIRSR617512-4 Domain

IPR017512 Proteobacteria

SRHMM617512-4 FTGRP_1 Disulfide bond SRHMM617512-4 C-C 1 PIRSR617653-1 Domain

IPR017653 Bacteria

SRHMM617653-1 H Proton acceptor SRHMM617653-1 K Proton acceptor 1 PIRSR617653-2 Domain

IPR017653 Bacteria

SRHMM617653-2 H Substrate SRHMM617653-2 H-x-N Substrate binding SRHMM617653-2 Y Substrate SRHMM617653-2 N Substrate SRHMM617653-2 D-x-N Substrate binding SRHMM617653-2 T Substrate SRHMM617653-2 K Substrate SRHMM617653-2 H Substrate SRHMM617653-2 R Substrate 1 PIRSR617653-3 Domain

IPR017653 Bacteria

SRHMM617653-3 FTGRP_1 SRHMM617653-3 FTGRP_2 SRHMM617653-3 FTGRP_3 Magnesium Metal-binding Mg(2+) SRHMM617653-3 D Magnesium SRHMM617653-3 N Magnesium SRHMM617653-3 E Magnesium 1 PIRSR617711-1 Domain

IPR017711 Bacteria

SRHMM617711-1 Y Proton acceptor 1 PIRSR617711-2 Domain

IPR017711 Bacteria

SRHMM617711-2 FTGRP_1 SRHMM617711-2 FTGRP_2 SRHMM617711-2 FTGRP_3 NAD SRHMM617711-2 L-x(26)-D NAD SRHMM617711-2 D NAD SRHMM617711-2 K NAD 1 PIRSR617736-1 Domain

IPR017736 Eukaryota Bacteria Archaea

SRHMM617736-1 E Proton donor E Nucleophile 1 PIRSR617736-2 Domain

IPR017736 Eukaryota Bacteria Archaea

SRHMM617736-2 Q Substrate SRHMM617736-2 N Substrate SRHMM617736-2 E-W Substrate binding SRHMM617736-2 Y Substrate SRHMM617736-2 H Substrate SRHMM617736-2 W Substrate 1 PIRSR617763-1 Domain

IPR017763 Bacteria

SRHMM617763-1 C Cysteine persulfide intermediate 1 PIRSR617774-1 Domain

IPR017774 Fungi Bacteria

SRHMM617774-1 E Proton donor 1 PIRSR617774-2 Domain

IPR017774 Fungi Bacteria

SRHMM617774-2 FTGRP_1 SRHMM617774-2 FTGRP_2 SRHMM617774-2 FTGRP_3 SRHMM617774-2 FTGRP_4 SRHMM617774-2 FTGRP_5 SRHMM617774-2 FTGRP_6 SRHMM617774-2 FTGRP_7 SRHMM617774-2 FTGRP_8 Manganese Metal-binding Mn(2+) Binds 2 manganese ions per subunit. SRHMM617774-2 H Manganese 2 SRHMM617774-2 H Manganese 2 SRHMM617774-2 E Manganese 2 SRHMM617774-2 H Manganese 1 SRHMM617774-2 H Manganese 1 SRHMM617774-2 E Manganese 1 SRHMM617774-2 H Manganese 1 SRHMM617774-2 H Manganese 2 1 PIRSR617821-1 Domain

IPR017821 Bacteria

SRHMM617821-1 E 5-glutamyl coenzyme A thioester intermediate 1 PIRSR617821-2 Domain

IPR017821 Bacteria

SRHMM617821-2 G-x(3)-V Coenzyme A binding SRHMM617821-2 I Coenzyme A; via carbonyl oxygen SRHMM617821-2 K Coenzyme A SRHMM617821-2 G Coenzyme A; via amide nitrogen SRHMM617821-2 N Coenzyme A 1 PIRSR618044-1 Domain

IPR018044 Bacteria

SRHMM618044-1 S Acyl-ester intermediate K Proton acceptor S 1 PIRSR618044-2 Domain

IPR018044 Bacteria

SRHMM618044-2 K Substrate 1 PIRSR618191-1 Domain

IPR018191 Bacteria Archaea

SRHMM618191-1 P Proton acceptor; via imino nitrogen 1 PIRSR618319-50 Domain This rule was created based on analysis for RESID:AA0119.

IPR018319 Bacteria Archaea

SRHMM618319-50 FTGRP_1 Pyridoxal phosphate pyridoxal 5'-phosphate SRHMM618319-50 K N6-(pyridoxal phosphate)lysine 1 PIRSR619342-50 Domain

IPR019342 Eukaryota

SRHMM619342-50 FTGRP_1 Disulfide bond SRHMM619342-50 C-x(32)-C C-x(12)-C 1 PIRSR619502-1 Domain

IPR019502 Eukaryota

SRHMM619502-1 H S H S 1 PIRSR619502-2 Domain

IPR019502 Eukaryota

SRHMM619502-2 F-S Cleavage; by autolysis F-S Cleavage; by autolysis 1 PIRSR620004-1 Domain

IPR020004 Eukaryota

SRHMM620004-1 D 1 PIRSR620004-2 Domain

IPR020004 Eukaryota

SRHMM620004-2 A-x(8)-R ATP R Substrate T Substrate D Substrate G-x(8)-H ATP E Substrate H Substrate E Substrate 1 PIRSR620004-3 Domain

IPR020004 Eukaryota

SRHMM620004-3 H Zinc C Zinc C Zinc C Zinc 1 PIRSR620023-1 Domain

IPR020023 Bacteria

SRHMM620023-1 H Proton acceptor 1 PIRSR620023-2 Domain

IPR020023 Bacteria

SRHMM620023-2 E Substrate SRHMM620023-2 R Substrate SRHMM620023-2 S-S Substrate binding SRHMM620023-2 F-G Substrate binding 1 PIRSR620405-1 Domain

IPR020405 Eukaryota

SRHMM620405-1 C Phosphocysteine intermediate 1 PIRSR620443-50 Domain

IPR020443 Vertebrata Herpesvirales

SRHMM620443-50 FTGRP_1 SRHMM620443-50 FTGRP_2 Disulfide bond SRHMM620443-50 C-x(89)-C C-x(50)-C SRHMM620443-50 C Interchain 1 PIRSR620443-51 Domain

IPR020443 Vertebrata

SRHMM620443-51 FTGRP_1 Disulfide bond SRHMM620443-51 C-x(92)-C C-x(51)-C C-x(52)-C 1 PIRSR620777-50 Domain

IPR020777 Metazoa

SRHMM620777-50 D Proton acceptor 1 PIRSR620777-51 Domain

IPR020777 Metazoa

SRHMM620777-51 FTGRP_1 ATP-binding Nucleotide-binding SRHMM620777-51 L-x(7)-V ATP K ATP 1 PIRSR620777-52 Domain

IPR020777 Metazoa

SRHMM620777-52 Y Interaction with SHC1 Y Interaction with PLC-gamma-1 1 PIRSR621116-50 Domain This rule was created based on analysis for RESID:AA0025.

IPR021116 Eukaryota

SRHMM621116-50 FTGRP_1 Disulfide bond SRHMM621116-50 C-x(4)-C 1 PIRSR621537-50 Domain This rule was created based on analysis for RESID:AA0030 and RESID:AA0478.

IPR021537 Vertebrata

SRHMM621537-50 P 4-hydroxyproline P 4-hydroxyproline N (3S)-3-hydroxyasparagine 1 PIRSR621573-1 Domain

IPR021573 Viruses

SRHMM621573-1 D For RdRp activity D For RdRp activity SRHMM621573-1 H For protease 3C activity D For protease 3C activity C For protease 3C activity 1 PIRSR621573-2 Domain

IPR021573 Viruses

SRHMM621573-2 G-x(6)-S ATP 1 PIRSR621573-3 Domain

IPR021573 Viruses

SRHMM621573-3 Q-G Cleavage; by protease 3C SRHMM621573-3 Q-G Cleavage; by protease 3C SRHMM621573-3 G-P Cleavage; by ribosomal skip SRHMM621573-3 Q-G Cleavage; by protease 3C SRHMM621573-3 Q-G Cleavage; by protease 3C SRHMM621573-3 E-S Cleavage; by protease 3C SRHMM621573-3 Q-S Cleavage; by protease 3C SRHMM621573-3 Q-G Cleavage; by protease 3C SRHMM621573-3 Q-S Cleavage; by protease 3C 1 PIRSR621573-4 Domain

IPR021573 Viruses

SRHMM621573-4 FTGRP_1 Disulfide bond SRHMM621573-4 C-x-C 1 PIRSR621573-5 Domain

IPR021573 Viruses

SRHMM621573-5 C-x(11)-C 1 PIRSR621573-6 Domain

IPR021573 Viruses

SRHMM621573-6 Y Phosphotyrosine; by host SYK T Phosphothreonine; by host CK2 Y O-(5'-phospho-RNA)-tyrosine 1 PIRSR621573-7 Domain

IPR021573 Viruses

SRHMM621573-7 G N-myristoyl glycine; by host 1 PIRSR621573-8 Domain

IPR021573 Viruses

SRHMM621573-8 K-x(7)-P Nuclear localization signal 1 PIRSR622230-1 Domain

IPR022230 Viruses

SRHMM622230-1 H Charge relay system; for 3C-like serine proteinase activity D Charge relay system; for 3C-like serine proteinase activity S Charge relay system; for 3C-like serine proteinase activity SRHMM622230-1 C For Nsp1 papain-like cysteine proteinase activity H For Nsp1 papain-like cysteine proteinase activity SRHMM622230-1 C For Nsp2 cysteine proteinase activity H For Nsp2 cysteine proteinase activity 1 PIRSR622230-2 Domain

IPR022230 Viruses

SRHMM622230-2 FTGRP_1 SRHMM622230-2 FTGRP_2 SRHMM622230-2 FTGRP_3 SRHMM622230-2 FTGRP_4 SRHMM622230-2 FTGRP_5 SRHMM622230-2 FTGRP_6 SRHMM622230-2 FTGRP_7 SRHMM622230-2 FTGRP_8 SRHMM622230-2 FTGRP_9 SRHMM622230-2 FTGRP_10 SRHMM622230-2 FTGRP_11 SRHMM622230-2 FTGRP_12 SRHMM622230-2 FTGRP_13 SRHMM622230-2 FTGRP_14 SRHMM622230-2 FTGRP_15 SRHMM622230-2 FTGRP_16 Metal-binding Zinc SRHMM622230-2 C Zinc 1 SRHMM622230-2 C Zinc 4 SRHMM622230-2 C Zinc 4 SRHMM622230-2 H Zinc 3; via pros nitrogen SRHMM622230-2 C Zinc 1 SRHMM622230-2 C Zinc 1 SRHMM622230-2 H Zinc 4; via pros nitrogen SRHMM622230-2 H Zinc 3; via tele nitrogen SRHMM622230-2 C Zinc 1 SRHMM622230-2 C Zinc 2 SRHMM622230-2 C Zinc 2 SRHMM622230-2 C Zinc 3 SRHMM622230-2 C Zinc 4 SRHMM622230-2 C Zinc 2 SRHMM622230-2 C Zinc 3 SRHMM622230-2 C Zinc 2 1 PIRSR622230-3 Domain

IPR022230 Viruses

SRHMM622230-3 E-G Cleavage; by 3CLSP SRHMM622230-3 S Involved in mRNA transcription process SRHMM622230-3 Q-S Cleavage; by 3CLSP SRHMM622230-3 E-S Cleavage; by 3CLSP SRHMM622230-3 G-G Cleavage; by Nsp2 cysteine proteinase SRHMM622230-3 E-G Cleavage; by 3CLSP SRHMM622230-3 E-G Cleavage; by 3CLSP SRHMM622230-3 E-S Cleavage; by 3CLSP; in minor pathway SRHMM622230-3 E-A Cleavage; by 3CLSP SRHMM622230-3 E-S Cleavage; by 3CLSP; in major pathway SRHMM622230-3 G-G Cleavage; by PCP SRHMM622230-3 E-G Cleavage; by 3CLSP; in minor pathway 1 PIRSR622230-4 Domain

IPR022230 Viruses

SRHMM622230-4 N-x-S N-linked (GlcNAc...) asparagine; by host 1 PIRSR622312-50 Domain

IPR022312 Eukaryota

SRHMM622312-50 K Schiff-base intermediate with DNA 1 PIRSR622314-1 Domain

IPR022314 Bacteria

SRHMM622314-1 Y Proton donor/acceptor 1 PIRSR622314-2 Domain

IPR022314 Bacteria

SRHMM622314-2 N Substrate SRHMM622314-2 R Substrate SRHMM622314-2 H Substrate 1 PIRSR622314-3 Domain

IPR022314 Bacteria

SRHMM622314-3 S 2,3-didehydroalanine (Ser) 1 PIRSR622314-4 Domain

IPR022314 Bacteria

SRHMM622314-4 A-x-G 5-imidazolinone (Ala-Gly) 1 PIRSR622350-50 Domain

IPR022350 Vertebrata

SRHMM622350-50 FTGRP_1 Disulfide bond SRHMM622350-50 C-x(37)-C C-x(38)-C C-x(4)-C 1 PIRSR623088-1 Domain

IPR023088 Eukaryota

SRHMM623088-1 H Proton donor 1 PIRSR623088-2 Domain

IPR023088 Eukaryota

SRHMM623088-2 H-x(3)-H cNMP D cNMP D cNMP Q cNMP 1 PIRSR623088-3 Domain

IPR023088 Eukaryota

SRHMM623088-3 FTGRP_1 SRHMM623088-3 FTGRP_2 SRHMM623088-3 FTGRP_3 SRHMM623088-3 FTGRP_4 Metal-binding SRHMM623088-3 H Divalent metal cation 1 SRHMM623088-3 D Divalent metal cation 1 SRHMM623088-3 H Divalent metal cation 1 SRHMM623088-3 D Divalent metal cation 1 D Divalent metal cation 2 1 PIRSR623237-1 Domain

IPR023237 Eukaryota

SRHMM623237-1 D SRHMM623237-1 C Nucleophile SRHMM623237-1 H 1 PIRSR623237-2 Domain

IPR023237 Eukaryota

SRHMM623237-2 D-x-R Linear diubiquitin binding SRHMM623237-2 F-x(3)-L Linear diubiquitin binding SRHMM623237-2 E Linear diubiquitin SRHMM623237-2 R-x-D Linear diubiquitin binding SRHMM623237-2 E-W Linear diubiquitin binding SRHMM623237-2 T-x(5)-V Linear diubiquitin binding 1 PIRSR623612-1 Domain

IPR023612 Bacteria

SRHMM623612-1 E H Proton donor 1 PIRSR625650-1 Domain

IPR025650 Eukaryota Bacteria

SRHMM625650-1 Y Proton donor/acceptor 1 PIRSR625650-2 Domain

IPR025650 Eukaryota Bacteria

SRHMM625650-2 R Substrate 1 PIRSR625650-3 Domain

IPR025650 Eukaryota Bacteria

SRHMM625650-3 FTGRP_1 SRHMM625650-3 FTGRP_2 SRHMM625650-3 FTGRP_3 SRHMM625650-3 FTGRP_4 FAD FAD SRHMM625650-3 T-x(2)-S FAD SRHMM625650-3 D-x(5)-[TI] FAD SRHMM625650-3 E-x(5)-[IV] FAD SRHMM625650-3 P-x(5)-S FAD 1 PIRSR625650-4 Domain

IPR025650 Eukaryota Bacteria

SRHMM625650-4 R Important for enzyme activity 1 PIRSR626945-1 Domain

IPR026945 Eukaryota

SRHMM626945-1 D Proton acceptor Y Nucleophile E 1 PIRSR626945-2 Domain

IPR026945 Eukaryota

SRHMM626945-2 R Substrate SRHMM626945-2 R Substrate SRHMM626945-2 R Substrate SRHMM626945-2 Y Substrate SRHMM626945-2 Y Substrate SRHMM626945-2 E Substrate SRHMM626945-2 R Substrate 1 PIRSR627053-1 Domain

IPR027053 Eukaryota

SRHMM627053-1 E 1 PIRSR627053-2 Domain

IPR027053 Eukaryota

SRHMM627053-2 FTGRP_1 SRHMM627053-2 FTGRP_2 SRHMM627053-2 FTGRP_3 SRHMM627053-2 FTGRP_4 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM627053-2 H Zinc; via tele nitrogen; catalytic SRHMM627053-2 H Zinc; via tele nitrogen; catalytic SRHMM627053-2 C Zinc; in inhibited form SRHMM627053-2 H Zinc; via tele nitrogen; catalytic 1 PIRSR627053-3 Domain

IPR027053 Eukaryota

SRHMM627053-3 R-[TA] Cleavage; by furin and PCSK7 1 PIRSR627053-4 Domain

IPR027053 Eukaryota

SRHMM627053-4 FTGRP_1 SRHMM627053-4 FTGRP_2 SRHMM627053-4 FTGRP_3 SRHMM627053-4 FTGRP_4 SRHMM627053-4 FTGRP_5 SRHMM627053-4 FTGRP_6 SRHMM627053-4 FTGRP_7 SRHMM627053-4 FTGRP_8 SRHMM627053-4 FTGRP_9 SRHMM627053-4 FTGRP_10 SRHMM627053-4 FTGRP_11 SRHMM627053-4 FTGRP_12 SRHMM627053-4 FTGRP_13 SRHMM627053-4 FTGRP_14 Disulfide bond SRHMM627053-4 C-x(31)-C SRHMM627053-4 C-x(5)-C SRHMM627053-4 C-x(12)-C SRHMM627053-4 C-x(44)-C SRHMM627053-4 C-x(26)-C SRHMM627053-4 C-x(31)-C SRHMM627053-4 C-x(25)-C SRHMM627053-4 C-x(14)-C SRHMM627053-4 C-x(34)-C SRHMM627053-4 C-x(11)-C SRHMM627053-4 C-x(12)-C SRHMM627053-4 C-x(18)-C SRHMM627053-4 C-x(7)-C SRHMM627053-4 C-x(25)-C 1 PIRSR627053-5 Domain

IPR027053 Eukaryota

SRHMM627053-5 FTGRP_1 SRHMM627053-5 FTGRP_2 SRHMM627053-5 FTGRP_3 SRHMM627053-5 FTGRP_4 Glycoprotein SRHMM627053-5 N-x-S N-linked (GlcNAc...) asparagine SRHMM627053-5 N-x-T N-linked (GlcNAc...) asparagine SRHMM627053-5 N-x-S N-linked (GlcNAc...) asparagine SRHMM627053-5 N-x-T N-linked (GlcNAc...) asparagine 1 PIRSR627057-1 Domain

IPR027057 Eukaryota Bacteria Archaea

SRHMM627057-1 E D Proton donor 1 PIRSR627057-2 Domain

IPR027057 Eukaryota Bacteria Archaea

SRHMM627057-2 FTGRP_1 SRHMM627057-2 FTGRP_2 SRHMM627057-2 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM627057-2 H Zinc; catalytic SRHMM627057-2 H Zinc; catalytic SRHMM627057-2 E Zinc; catalytic 1 PIRSR627086-1 Domain

IPR027086 Eukaryota

SRHMM627086-1 D Proton acceptor 1 PIRSR627173-50 Domain

IPR027173 Vertebrata

SRHMM627173-50 FTGRP_1 Disulfide bond SRHMM627173-50 C-x(8)-C C-x(26)-C C-x(27)-C C-x(44)-C 1 PIRSR627173-51 Domain

IPR027173 Vertebrata

SRHMM627173-51 FTGRP_1 Phosphoprotein SRHMM627173-51 Y Phosphotyrosine Y Phosphotyrosine 1 PIRSR627179-50 Domain

IPR027179 Eukaryota

SRHMM627179-50 FTGRP_1 Disulfide bond SRHMM627179-50 C-x(30)-C C-x(10)-C C-x(10)-C 1 PIRSR627185-50 Domain

IPR027185 Vertebrata

SRHMM627185-50 E 1 PIRSR627185-51 Domain

IPR027185 Vertebrata

SRHMM627185-51 FTGRP_1 The ATG16L1-binding motif mediates interaction with ATG16L1. SRHMM627185-51 Y-x(16)-L ATG16L1-binding motif 1 PIRSR627185-52 Domain

IPR027185 Vertebrata

SRHMM627185-52 F Interaction with bacterial lipopeptide 1 PIRSR627185-53 Domain

IPR027185 Vertebrata

SRHMM627185-53 FTGRP_1 Disulfide bond SRHMM627185-53 C-x(5)-C C-x(28)-C C-x(21)-C 1 PIRSR627185-54 Domain

IPR027185 Vertebrata

SRHMM627185-54 FTGRP_1 Isopeptide bond Ubl conjugation SRHMM627185-54 K Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) 1 PIRSR627620-1 Domain

IPR027620 Bacteria Archaea

SRHMM627620-1 D For DNase activity of RuvC domain SRHMM627620-1 D For DNase activity of RuvC domain SRHMM627620-1 E For DNase activity of RuvC domain SRHMM627620-1 K For pre-crRNA processing SRHMM627620-1 H For pre-crRNA processing SRHMM627620-1 K For pre-crRNA processing 1 PIRSR627620-2 Domain

IPR027620 Bacteria Archaea

SRHMM627620-2 K-x(2)-S Binds crRNA SRHMM627620-2 K-x(2)-L Binds crRNA in crRNA-target DNA heteroduplex SRHMM627620-2 Y-x(3)-K Binds crRNA alone and in crRNA-target DNA heteroduplex SRHMM627620-2 L-H Binds crRNA SRHMM627620-2 N-x(3)-N Binds DNA in crRNA-target DNA heteroduplex SRHMM627620-2 F-x(3)-R Binds crRNA alone and in crRNA-target DNA heteroduplex SRHMM627620-2 Y-x(3)-K Binds crRNA SRHMM627620-2 H-x(2)-K Binds crRNA in crRNA-target DNA heteroduplex SRHMM627620-2 Y-x(7)-F Binds crRNA 1 PIRSR627620-3 Domain

IPR027620 Bacteria Archaea

SRHMM627620-3 S Binds DNA in crRNA-target DNA heteroduplex SRHMM627620-3 R Binds crRNA SRHMM627620-3 K Binds PAM SRHMM627620-3 T Binds crRNA alone and in crRNA-target DNA heteroduplex SRHMM627620-3 Y Caps the crRNA-target DNA heteroduplex SRHMM627620-3 K Binds DNA in crRNA-target DNA heteroduplex SRHMM627620-3 K Binds DNA in crRNA-target DNA heteroduplex SRHMM627620-3 K Binds Target strand DNA SRHMM627620-3 K Binds Target strand DNA SRHMM627620-3 K Binds DNA protospacer adjacent motif (PAM) SRHMM627620-3 G Binds Target strand DNA; via amide nitrogen 1 PIRSR628131-1 Domain

IPR028131 Eukaryota

SRHMM628131-1 C H S 1 PIRSR628391-1 Domain

IPR028391 Eukaryota

SRHMM628391-1 H H 1 PIRSR628391-2 Domain

IPR028391 Eukaryota

SRHMM628391-2 R Substrate SRHMM628391-2 K Substrate SRHMM628391-2 K-x(26)-K Substrate binding SRHMM628391-2 S Substrate SRHMM628391-2 K Substrate 1 PIRSR628391-3 Domain

IPR028391 Eukaryota

SRHMM628391-3 FTGRP_1 SRHMM628391-3 FTGRP_2 SRHMM628391-3 FTGRP_3 SRHMM628391-3 FTGRP_4 SRHMM628391-3 FTGRP_5 SRHMM628391-3 FTGRP_6 SRHMM628391-3 FTGRP_7 SRHMM628391-3 FTGRP_8 SRHMM628391-3 FTGRP_9 SRHMM628391-3 FTGRP_10 Calcium Metal-binding Ca(2+) Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. SRHMM628391-3 N Calcium 1; catalytic SRHMM628391-3 D Calcium 3 SRHMM628391-3 D Calcium 3 SRHMM628391-3 D Calcium 1; catalytic SRHMM628391-3 N Calcium 2 SRHMM628391-3 E Calcium 1; catalytic SRHMM628391-3 E Calcium 1; catalytic SRHMM628391-3 I Calcium 2; via carbonyl oxygen SRHMM628391-3 Y Calcium 3; via carbonyl oxygen SRHMM628391-3 D Calcium 2 1 PIRSR628391-4 Domain

IPR028391 Eukaryota

SRHMM628391-4 FTGRP_1 SRHMM628391-4 FTGRP_2 Glycoprotein SRHMM628391-4 S O-linked (GlcNAc) serine SRHMM628391-4 T O-linked (GlcNAc) threonine 1 PIRSR628472-1 Domain

IPR028472 Eukaryota

SRHMM628472-1 D Nucleophile D Proton donor 1 PIRSR628472-2 Domain

IPR028472 Eukaryota

SRHMM628472-2 FTGRP_1 SRHMM628472-2 FTGRP_2 SRHMM628472-2 FTGRP_3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM628472-2 D Magnesium SRHMM628472-2 D Magnesium SRHMM628472-2 D Magnesium; via carbonyl oxygen 1 PIRSR628651-50 Domain

IPR028651 Eukaryota

SRHMM628651-50 Y Histone H3K4me3 M Histone H3K4me3 D Histone H3K4me3 W Histone H3K4me3 1 PIRSR628651-51 Domain

IPR028651 Eukaryota

SRHMM628651-51 FTGRP_1 Metal-binding Zinc SRHMM628651-51 C Zinc 1 C Zinc 1 C Zinc 2 C Zinc 2 H Zinc 1; via pros nitrogen C Zinc 1 C Zinc 2 C Zinc 2 1 PIRSR628707-1 Domain

IPR028707 Eukaryota

SRHMM628707-1 E 1 PIRSR628707-2 Domain

IPR028707 Eukaryota

SRHMM628707-2 FTGRP_2 SRHMM628707-2 FTGRP_3 SRHMM628707-2 FTGRP_8 SRHMM628707-2 FTGRP_12 SRHMM628707-2 FTGRP_15 SRHMM628707-2 FTGRP_16 SRHMM628707-2 FTGRP_17 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. SRHMM628707-2 FTGRP_1 SRHMM628707-2 FTGRP_4 SRHMM628707-2 FTGRP_5 SRHMM628707-2 FTGRP_6 SRHMM628707-2 FTGRP_7 SRHMM628707-2 FTGRP_9 SRHMM628707-2 FTGRP_10 SRHMM628707-2 FTGRP_11 SRHMM628707-2 FTGRP_13 SRHMM628707-2 FTGRP_14 Calcium Metal-binding Ca(2+) Binds 2 calcium ions per subunit. SRHMM628707-2 D Zinc 1 SRHMM628707-2 D Calcium 1 SRHMM628707-2 H Zinc 1 SRHMM628707-2 H Zinc 2; catalytic SRHMM628707-2 H Zinc 2; catalytic SRHMM628707-2 G Calcium 1; via carbonyl oxygen SRHMM628707-2 H Zinc 2; catalytic SRHMM628707-2 D Calcium 2 SRHMM628707-2 D Calcium 1 SRHMM628707-2 G Calcium 1; via carbonyl oxygen SRHMM628707-2 T Calcium 2; via carbonyl oxygen SRHMM628707-2 E Calcium 2 SRHMM628707-2 H Zinc 1 SRHMM628707-2 H Zinc 1 SRHMM628707-2 D Calcium 2 SRHMM628707-2 G Calcium 2; via carbonyl oxygen SRHMM628707-2 G Calcium 2; via carbonyl oxygen 1 PIRSR628788-1 Domain

IPR028788 Eukaryota

SRHMM628788-1 D Proton acceptor 1 PIRSR628788-2 Domain

IPR028788 Eukaryota

SRHMM628788-2 FTGRP_1 SRHMM628788-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM628788-2 I-x(7)-V ATP SRHMM628788-2 K ATP 1 PIRSR628829-1 Domain

IPR028829 Eukaryota Bacteria

SRHMM628829-1 D Proton donor E Nucleophile 1 PIRSR629511-1 Domain

IPR029511 Eukaryota

SRHMM629511-1 Y Proton acceptor 1 PIRSR629511-2 Domain

IPR029511 Eukaryota

SRHMM629511-2 FTGRP_1 SRHMM629511-2 FTGRP_3 NADP SRHMM629511-2 L-x(23)-V NADP SRHMM629511-2 S Substrate SRHMM629511-2 K NADP 1 PIRSR629539-1 Domain

IPR029539 Eukaryota

SRHMM629539-1 N SRHMM629539-1 C SRHMM629539-1 H 1 PIRSR629576-1 Domain

IPR029576 Eukaryota

SRHMM629576-1 H Proton acceptor Y For cyclooxygenase activity 1 PIRSR629576-2 Domain

IPR029576 Eukaryota

SRHMM629576-2 R Substrate Y Substrate 1 PIRSR629576-3 Domain

IPR029576 Eukaryota

SRHMM629576-3 FTGRP_1 Heme Iron Metal-binding heme b Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit. SRHMM629576-3 H Iron (heme axial ligand) 1 PIRSR629576-4 Domain

IPR029576 Eukaryota

SRHMM629576-4 S Aspirin-acetylated serine 1 PIRSR629576-5 Domain

IPR029576 Eukaryota

SRHMM629576-5 FTGRP_1 SRHMM629576-5 FTGRP_2 SRHMM629576-5 FTGRP_3 SRHMM629576-5 FTGRP_4 SRHMM629576-5 FTGRP_5 Disulfide bond SRHMM629576-5 C-x(10)-C SRHMM629576-5 C-x(122)-C SRHMM629576-5 C-x(15)-C SRHMM629576-5 C-x(9)-C SRHMM629576-5 C-x(5)-C 1 PIRSR629576-6 Domain

IPR029576 Metazoa

SRHMM629576-6 FTGRP_1 SRHMM629576-6 FTGRP_2 SRHMM629576-6 FTGRP_3 SRHMM629576-6 FTGRP_4 Glycoprotein SRHMM629576-6 N-x-[TS] N-linked (GlcNAc...) asparagine SRHMM629576-6 N-x-S N-linked (GlcNAc...) asparagine SRHMM629576-6 N-x-[ST] N-linked (GlcNAc...) asparagine SRHMM629576-6 N-x-S N-linked (GlcNAc...) asparagine 1 PIRSR629580-1 Domain

IPR029580 Eukaryota

SRHMM629580-1 H Proton acceptor Y For cyclooxygenase activity 1 PIRSR629580-2 Domain

IPR029580 Eukaryota

SRHMM629580-2 FTGRP_1 Heme Iron Metal-binding heme b Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit. SRHMM629580-2 H Iron (heme axial ligand) 1 PIRSR629580-3 Domain

IPR029580 Eukaryota

SRHMM629580-3 S Aspirin-acetylated serine 1 PIRSR629580-4 Domain

IPR029580 Eukaryota

SRHMM629580-4 FTGRP_1 SRHMM629580-4 FTGRP_2 SRHMM629580-4 FTGRP_3 SRHMM629580-4 FTGRP_4 SRHMM629580-4 FTGRP_5 Disulfide bond SRHMM629580-4 C-x(15)-C SRHMM629580-4 C-x(121)-C SRHMM629580-4 C-x(5)-C SRHMM629580-4 C-x(9)-C SRHMM629580-4 C-x(10)-C 1 PIRSR629580-5 Domain

IPR029580 Metazoa

SRHMM629580-5 FTGRP_1 SRHMM629580-5 FTGRP_2 SRHMM629580-5 FTGRP_3 Glycoprotein SRHMM629580-5 N-x-[ST] N-linked (GlcNAc...) asparagine SRHMM629580-5 N-x-[ST] N-linked (GlcNAc...) asparagine SRHMM629580-5 N-x-[TS] N-linked (GlcNAc...) asparagine 1 PIRSR629601-1 Domain

IPR029601 Eukaryota

SRHMM629601-1 D Proton acceptor 1 PIRSR629601-2 Domain

IPR029601 Eukaryota

SRHMM629601-2 FTGRP_1 SRHMM629601-2 FTGRP_2 SRHMM629601-2 FTGRP_3 SRHMM629601-2 FTGRP_4 SRHMM629601-2 FTGRP_5 SRHMM629601-2 FTGRP_6 ATP-binding Nucleotide-binding SRHMM629601-2 E ATP SRHMM629601-2 R ATP SRHMM629601-2 G-x(5)-E ATP SRHMM629601-2 K ATP SRHMM629601-2 D ATP SRHMM629601-2 Q ATP 1 PIRSR629601-3 Domain

IPR029601 Eukaryota

SRHMM629601-3 FTGRP_1 SRHMM629601-3 FTGRP_2 SRHMM629601-3 FTGRP_3 SRHMM629601-3 FTGRP_4 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM629601-3 C Zinc SRHMM629601-3 H Zinc SRHMM629601-3 H Zinc SRHMM629601-3 C Zinc 1 PIRSR629609-1 Domain

IPR029609 Eukaryota

SRHMM629609-1 H Proton acceptor 1 PIRSR629609-2 Domain

IPR029609 Eukaryota

SRHMM629609-2 FTGRP_1 Heme heme b Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer. SRHMM629609-2 D Heme (covalent; via 3 links) E Heme (covalent; via 3 links) M Heme (covalent; via 3 links) 1 PIRSR629609-3 Domain

IPR029609 Eukaryota

SRHMM629609-3 FTGRP_6 Iron SRHMM629609-3 FTGRP_1 SRHMM629609-3 FTGRP_2 SRHMM629609-3 FTGRP_3 SRHMM629609-3 FTGRP_4 SRHMM629609-3 FTGRP_5 Calcium Ca(2+) Binds 1 Ca(2+) ion per monomer. SRHMM629609-3 FTGRP_1 SRHMM629609-3 FTGRP_2 SRHMM629609-3 FTGRP_3 SRHMM629609-3 FTGRP_4 SRHMM629609-3 FTGRP_5 SRHMM629609-3 FTGRP_6 Metal-binding SRHMM629609-3 D Calcium SRHMM629609-3 D Calcium SRHMM629609-3 T Calcium SRHMM629609-3 H Iron (heme axial ligand) SRHMM629609-3 F Calcium; via carbonyl oxygen SRHMM629609-3 S Calcium 1 PIRSR629609-4 Domain

IPR029609 Eukaryota

SRHMM629609-4 R Transition state stabilizer 1 PIRSR629609-5 Domain

IPR029609 Eukaryota

SRHMM629609-5 FTGRP_1 SRHMM629609-5 FTGRP_2 SRHMM629609-5 FTGRP_3 SRHMM629609-5 FTGRP_4 SRHMM629609-5 FTGRP_5 SRHMM629609-5 FTGRP_6 SRHMM629609-5 FTGRP_7 Disulfide bond SRHMM629609-5 C-x(10)-C SRHMM629609-5 C-x(12)-C SRHMM629609-5 C-x(9)-C SRHMM629609-5 C-x(23)-C SRHMM629609-5 C Interchain SRHMM629609-5 C-x(25)-C SRHMM629609-5 C-x(56)-C 1 PIRSR629609-6 Domain

IPR029609 Eukaryota

SRHMM629609-6 FTGRP_1 SRHMM629609-6 FTGRP_2 SRHMM629609-6 FTGRP_3 SRHMM629609-6 FTGRP_4 SRHMM629609-6 FTGRP_5 SRHMM629609-6 FTGRP_6 Glycoprotein SRHMM629609-6 N-x-[ST] N-linked (GlcNAc...) asparagine SRHMM629609-6 N-x-S N-linked (GlcNAc...) asparagine SRHMM629609-6 N-x-T N-linked (GlcNAc...) asparagine SRHMM629609-6 N-x-S N-linked (GlcNAc...) asparagine SRHMM629609-6 N-x-[ST] N-linked (GlcNAc...) asparagine SRHMM629609-6 N-x-T N-linked (GlcNAc...) asparagine 1 PIRSR629727-1 Domain

IPR029727 Eukaryota

SRHMM629727-1 D Proton donor SRHMM629727-1 E 1 PIRSR629727-2 Domain

IPR029727 Eukaryota

SRHMM629727-2 FTGRP_1 SRHMM629727-2 FTGRP_2 SRHMM629727-2 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM629727-2 H Zinc; catalytic SRHMM629727-2 H Zinc; catalytic SRHMM629727-2 E Zinc; catalytic 1 PIRSR629727-3 Domain

IPR029727 Eukaryota

SRHMM629727-3 FTGRP_1 SRHMM629727-3 FTGRP_2 SRHMM629727-3 FTGRP_3 SRHMM629727-3 FTGRP_4 SRHMM629727-3 FTGRP_5 Disulfide bond SRHMM629727-3 C-x(267)-C SRHMM629727-3 C-x(7)-C SRHMM629727-3 C-x(4)-C SRHMM629727-3 C-x(606)-C SRHMM629727-3 C-x(654)-C 1 PIRSR629727-4 Domain

IPR029727 Eukaryota

SRHMM629727-4 FTGRP_1 SRHMM629727-4 FTGRP_2 SRHMM629727-4 FTGRP_4 Glycoprotein SRHMM629727-4 N-x-[T] N-linked (GlcNAc...) asparagine SRHMM629727-4 N-x-[ST] N-linked (GlcNAc...) asparagine SRHMM629727-4 N-x-[T] N-linked (GlcNAc...) asparagine SRHMM629727-4 N-x-[ST] N-linked (GlcNAc...) asparagine 1 PIRSR629881-1 Domain

IPR029881 Eukaryota

SRHMM629881-1 T Nucleophile 1 PIRSR629881-2 Domain

IPR029881 Eukaryota

SRHMM629881-2 Y Substrate SRHMM629881-2 N Substrate 1 PIRSR629881-3 Domain

IPR029881 Eukaryota

SRHMM629881-3 FTGRP_8 SRHMM629881-3 FTGRP_9 SRHMM629881-3 FTGRP_10 SRHMM629881-3 FTGRP_11 SRHMM629881-3 FTGRP_12 Ca(2+) Binds 1 Ca(2+) ion per subunit. SRHMM629881-3 FTGRP_1 SRHMM629881-3 FTGRP_2 SRHMM629881-3 FTGRP_3 SRHMM629881-3 FTGRP_4 SRHMM629881-3 FTGRP_5 SRHMM629881-3 FTGRP_6 SRHMM629881-3 FTGRP_7 Zn(2+) Binds 2 Zn(2+) ions per subunit. SRHMM629881-3 FTGRP_1 SRHMM629881-3 FTGRP_2 SRHMM629881-3 FTGRP_3 SRHMM629881-3 FTGRP_4 SRHMM629881-3 FTGRP_5 SRHMM629881-3 FTGRP_6 SRHMM629881-3 FTGRP_7 SRHMM629881-3 FTGRP_8 SRHMM629881-3 FTGRP_9 SRHMM629881-3 FTGRP_10 SRHMM629881-3 FTGRP_11 SRHMM629881-3 FTGRP_12 Metal-binding SRHMM629881-3 D Zinc 1; catalytic SRHMM629881-3 [ND] Calcium SRHMM629881-3 H Zinc 2; via tele nitrogen; catalytic SRHMM629881-3 H Zinc 1; via tele nitrogen; catalytic SRHMM629881-3 D Calcium SRHMM629881-3 [ND] Calcium SRHMM629881-3 D Zinc 2; catalytic SRHMM629881-3 D Calcium SRHMM629881-3 L Calcium; via carbonyl oxygen SRHMM629881-3 D Zinc 1; catalytic SRHMM629881-3 T Zinc 1; catalytic SRHMM629881-3 H Zinc 2; via tele nitrogen; catalytic 1 PIRSR629881-4 Domain

IPR029881 Eukaryota

SRHMM629881-4 K Essential for catalytic activity 1 PIRSR629890-1 Domain

IPR029890 Eukaryota

SRHMM629890-1 T AMP-threonine intermediate 1 PIRSR629890-2 Domain

IPR029890 Eukaryota

SRHMM629890-2 K Substrate SRHMM629890-2 N Substrate SRHMM629890-2 S Substrate 2'-3'-cGAMP SRHMM629890-2 D Substrate Y Substrate H Substrate 2'-3'-cGAMP 1 PIRSR629890-3 Domain

IPR029890 Eukaryota

SRHMM629890-3 FTGRP_8 SRHMM629890-3 FTGRP_9 SRHMM629890-3 FTGRP_10 SRHMM629890-3 FTGRP_11 SRHMM629890-3 FTGRP_12 Calcium SRHMM629890-3 FTGRP_1 SRHMM629890-3 FTGRP_2 SRHMM629890-3 FTGRP_3 SRHMM629890-3 FTGRP_4 SRHMM629890-3 FTGRP_5 SRHMM629890-3 FTGRP_6 SRHMM629890-3 FTGRP_7 Zinc SRHMM629890-3 FTGRP_1 SRHMM629890-3 FTGRP_2 SRHMM629890-3 FTGRP_3 SRHMM629890-3 FTGRP_4 SRHMM629890-3 FTGRP_5 SRHMM629890-3 FTGRP_6 SRHMM629890-3 FTGRP_7 SRHMM629890-3 FTGRP_8 SRHMM629890-3 FTGRP_9 SRHMM629890-3 FTGRP_10 SRHMM629890-3 FTGRP_11 SRHMM629890-3 FTGRP_12 Metal-binding SRHMM629890-3 D Calcium SRHMM629890-3 D Calcium SRHMM629890-3 D Zinc 1; catalytic SRHMM629890-3 H Zinc 2; via tele nitrogen; catalytic SRHMM629890-3 D Calcium SRHMM629890-3 H Zinc 2; via tele nitrogen; catalytic SRHMM629890-3 H Zinc 1; via tele nitrogen; catalytic SRHMM629890-3 D Calcium SRHMM629890-3 D Zinc 2; catalytic SRHMM629890-3 R Calcium; via carbonyl oxygen SRHMM629890-3 D Zinc 1; catalytic SRHMM629890-3 T Zinc 1; catalytic 1 PIRSR629890-4 Domain

IPR029890 Eukaryota

SRHMM629890-4 FTGRP_1 SRHMM629890-4 FTGRP_2 SRHMM629890-4 FTGRP_3 SRHMM629890-4 FTGRP_4 SRHMM629890-4 FTGRP_5 SRHMM629890-4 FTGRP_6 SRHMM629890-4 FTGRP_7 SRHMM629890-4 FTGRP_8 SRHMM629890-4 FTGRP_9 SRHMM629890-4 FTGRP_10 SRHMM629890-4 FTGRP_11 SRHMM629890-4 FTGRP_12 SRHMM629890-4 FTGRP_13 SRHMM629890-4 FTGRP_14 SRHMM629890-4 FTGRP_15 SRHMM629890-4 FTGRP_16 Disulfide bond SRHMM629890-4 C-x(12)-C SRHMM629890-4 C-x(16)-C SRHMM629890-4 C-x(98)-C SRHMM629890-4 C-x(13)-C SRHMM629890-4 C-x(82)-C SRHMM629890-4 C-x(27)-C SRHMM629890-4 C-x(5)-C SRHMM629890-4 C-x(5)-C SRHMM629890-4 C-x(56)-C SRHMM629890-4 C-x(211)-C SRHMM629890-4 C-x(386)-C SRHMM629890-4 C-x(9)-C SRHMM629890-4 C-x(29)-C SRHMM629890-4 C-x(45)-C SRHMM629890-4 C-x(99)-C SRHMM629890-4 C-x(12)-C 1 PIRSR630056-1 Domain

IPR030056 Eukaryota

SRHMM630056-1 E D 1 PIRSR630056-2 Domain

IPR030056 Eukaryota

SRHMM630056-2 D Substrate 1 PIRSR630056-3 Domain

IPR030056 Eukaryota

SRHMM630056-3 FTGRP_1 SRHMM630056-3 FTGRP_2 SRHMM630056-3 FTGRP_3 SRHMM630056-3 FTGRP_4 Disulfide bond SRHMM630056-3 C-x(120)-C SRHMM630056-3 C-x(84)-C SRHMM630056-3 C-x(15)-C SRHMM630056-3 C-x(17)-C 1 PIRSR630220-1 Domain

IPR030220 Eukaryota

SRHMM630220-1 D Proton acceptor 1 PIRSR630220-2 Domain

IPR030220 Eukaryota

SRHMM630220-2 FTGRP_1 SRHMM630220-2 FTGRP_2 ATP-binding Nucleotide-binding SRHMM630220-2 K ATP SRHMM630220-2 L-x(7)-V ATP 1 PIRSR630294-1 Domain

IPR030294 Eukaryota

SRHMM630294-1 S Nucleophile D Charge relay system H Charge relay system 1 PIRSR630294-2 Domain

IPR030294 Eukaryota

SRHMM630294-2 FTGRP_1 SRHMM630294-2 FTGRP_2 SRHMM630294-2 FTGRP_3 Disulfide bond SRHMM630294-2 C-C SRHMM630294-2 C-x(7)-C SRHMM630294-2 C-x(31)-C 1 PIRSR630294-3 Domain

IPR030294 Eukaryota

SRHMM630294-3 FTGRP_1 SRHMM630294-3 FTGRP_2 SRHMM630294-3 FTGRP_3 Glycoprotein SRHMM630294-3 N-x-[ST] N-linked (GlcNAc...) asparagine SRHMM630294-3 N-x-S N-linked (GlcNAc...) asparagine SRHMM630294-3 N-x-[ST] N-linked (GlcNAc...) asparagine 1 PIRSR630295-50 Domain

IPR030295 Metazoa

SRHMM630295-50 S Nucleophile D H 1 PIRSR630295-51 Domain

IPR030295 Metazoa

SRHMM630295-51 FTGRP_1 Disulfide bond SRHMM630295-51 C-x(7)-C C-x(10)-C C-x(19)-C 1 PIRSR630297-1 Domain

IPR030297 Eukaryota

SRHMM630297-1 C Nucleophile H Proton donor 1 PIRSR630297-2 Domain

IPR030297 Eukaryota

SRHMM630297-2 D Important for enzyme activity 1 PIRSR630560-1 Domain

IPR030560 Eukaryota

SRHMM630560-1 K Charge relay system S Charge relay system S Acyl-ester intermediate 1 PIRSR630560-2 Domain

IPR030560 Eukaryota

SRHMM630560-2 M Substrate; via carbonyl oxygen S Substrate I-x(2)-S Substrate binding 1 PIRSR630564-1 Domain

IPR030564 Eukaryota

SRHMM630564-1 C Phosphocysteine intermediate 1 PIRSR630564-2 Domain

IPR030564 Eukaryota

SRHMM630564-2 N-I Substrate binding SRHMM630564-2 C-x(5)-R Substrate binding SRHMM630564-2 N-x(2)-K Substrate binding 1 PIRSR630616-1 Domain

IPR030616 Eukaryota

SRHMM630616-1 D Proton acceptor 1 PIRSR631038-1 Domain

IPR031038 Bacteria

SRHMM631038-1 E Proton acceptor 1 PIRSR631038-2 Domain

IPR031038 Bacteria

SRHMM631038-2 Y Substrate R Substrate Y Substrate R Substrate 1 PIRSR631048-50 Domain

IPR031048 Eukaryota

SRHMM631048-50 D Proton acceptor 1 PIRSR631048-51 Domain

IPR031048 Eukaryota

SRHMM631048-51 FTGRP_1 ATP-binding Nucleotide-binding SRHMM631048-51 [LVI]-x(7)-[VL] ATP [KRS] ATP; via carbonyl oxygen K ATP P-x-M ATP K ATP 1 PIRSR631048-52 Domain

IPR031048 Eukaryota

SRHMM631048-52 FTGRP_1 Disulfide bond SRHMM631048-52 C-x(6)-C 1 PIRSR631084-1 Domain

IPR031084 Metazoa

SRHMM631084-1 D C Nucleophile H 1 PIRSR631098-50 Domain This rule was created based on analysis for RESID:AA0031.

IPR031098 Ecdysozoa

SRHMM631098-50 FTGRP_1 Pyrrolidone carboxylic acid SRHMM631098-50 Q Pyrrolidone carboxylic acid 1 PIRSR631098-51 Domain This rule was created based on analysis for RESID:AA0025.

IPR031098 Eukaryota

SRHMM631098-51 FTGRP_1 Disulfide bond SRHMM631098-51 C-x(35)-C C-x(15)-C C-x(25)-C 1 PIRSR631245-1 Domain

IPR031245 Eukaryota

SRHMM631245-1 S Charge relay system D Charge relay system H Charge relay system 1 PIRSR631245-2 Domain

IPR031245 Eukaryota

SRHMM631245-2 E-E Substrate binding 1 PIRSR631245-3 Domain

IPR031245 Eukaryota

SRHMM631245-3 C-I Cleavage 1 PIRSR631245-4 Domain

IPR031245 Eukaryota

SRHMM631245-4 FTGRP_1 Disulfide bond SRHMM631245-4 C-x(10)-C C-x(2)-C C-x(17)-C C-x(111)-C 1 PIRSR631245-5 Domain

IPR031245 Eukaryota

SRHMM631245-5 FTGRP_1 SRHMM631245-5 FTGRP_2 SRHMM631245-5 FTGRP_3 SRHMM631245-5 FTGRP_4 SRHMM631245-5 FTGRP_5 SRHMM631245-5 FTGRP_6 Glycoprotein SRHMM631245-5 N-x-T N-linked (GlcNAc...) asparagine SRHMM631245-5 N-x-[TS] N-linked (GlcNAc...) asparagine SRHMM631245-5 N-x-S N-linked (GlcNAc...) asparagine SRHMM631245-5 N-x-T N-linked (GlcNAc...) asparagine SRHMM631245-5 N-x-T N-linked (GlcNAc...) asparagine SRHMM631245-5 N-x-[ST] N-linked (GlcNAc...) asparagine 1 PIRSR632916-1 Domain

IPR032916 Eukaryota

SRHMM632916-1 C Nucleophile D H 1 PIRSR633019-50 Domain

IPR033019 Vertebrata

SRHMM633019-50 FTGRP_1 Disulfide bond SRHMM633019-50 C-x(54)-C C-x(49)-C C-x(52)-C C-x(65)-C C-x(52)-C 1 PIRSR633040-1 Domain

IPR033040 Eukaryota

SRHMM633040-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR633040-2 Domain

IPR033040 Eukaryota

SRHMM633040-2 FTGRP_1 Disulfide bond SRHMM633040-2 C-x(15)-C C-x(67)-C C-x(15)-C C-x(26)-C 1 PIRSR633144-1 Domain

IPR033144 Eukaryota

SRHMM633144-1 D D 1 PIRSR633144-2 Domain

IPR033144 Eukaryota

SRHMM633144-2 FTGRP_1 SRHMM633144-2 FTGRP_2 SRHMM633144-2 FTGRP_3 SRHMM633144-2 FTGRP_4 Disulfide bond SRHMM633144-2 C-x(3)-C SRHMM633144-2 C-x(68)-C SRHMM633144-2 C-x(36)-C SRHMM633144-2 C-x(6)-C 1 PIRSR633144-3 Domain

IPR033144 Eukaryota

SRHMM633144-3 N-x-T N-linked (GlcNAc...) asparagine N-x-T N-linked (GlcNAc...) asparagine 1 PIRSR633195-1 Domain

IPR033195 Eukaryota Bacteria

SRHMM633195-1 D H C Amidino-cysteine intermediate 1 PIRSR633197-1 Domain

IPR033197 Eukaryota

SRHMM633197-1 H Proton donor C Nucleophile 1 PIRSR633197-2 Domain

IPR033197 Eukaryota

SRHMM633197-2 V Substrate; via carbonyl oxygen SRHMM633197-2 R Substrate SRHMM633197-2 R Substrate SRHMM633197-2 E-D Substrate binding SRHMM633197-2 D Substrate 1 PIRSR633197-3 Domain

IPR033197 Eukaryota

SRHMM633197-3 FTGRP_1 Metal-binding Zinc SRHMM633197-3 C Zinc 1 PIRSR633199-1 Domain

IPR033199 Eukaryota Bacteria Archaea

SRHMM633199-1 H Proton donor C Nucleophile 1 PIRSR633199-2 Domain

IPR033199 Eukaryota Bacteria Archaea

SRHMM633199-2 L Substrate; via carbonyl oxygen D Substrate E-D Substrate binding R Substrate R Substrate [IVL] Substrate; via carbonyl oxygen 1 PIRSR633478-1 Domain

IPR033478 Eukaryota

SRHMM633478-1 D C Nucleophile H Proton acceptor 1 PIRSR633478-2 Domain

IPR033478 Eukaryota

SRHMM633478-2 R-G Cleavage; by MALT1 1 PIRSR633508-1 Domain

IPR033508 Eukaryota

SRHMM633508-1 E Proton acceptor 1 PIRSR633508-2 Domain

IPR033508 Eukaryota

SRHMM633508-2 E Substrate G-x(3)-N Substrate binding R Substrate 1 PIRSR633508-3 Domain

IPR033508 Eukaryota

SRHMM633508-3 D Binds calcium which modulates its enzyme activity Y Transition state stabilizer 1 PIRSR633508-4 Domain

IPR033508 Eukaryota

SRHMM633508-4 FTGRP_1 SRHMM633508-4 FTGRP_2 SRHMM633508-4 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM633508-4 H Zinc; via tele nitrogen; catalytic SRHMM633508-4 E Zinc; catalytic SRHMM633508-4 H Zinc; via tele nitrogen; catalytic 1 PIRSR633528-1 Domain

IPR033528 Eukaryota

SRHMM633528-1 E Proton acceptor 1 PIRSR633528-2 Domain

IPR033528 Eukaryota

SRHMM633528-2 E Substrate SRHMM633528-2 G-x(3)-N Substrate binding 1 PIRSR633528-3 Domain

IPR033528 Eukaryota

SRHMM633528-3 FTGRP_1 SRHMM633528-3 FTGRP_2 SRHMM633528-3 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM633528-3 H Zinc; catalytic SRHMM633528-3 E Zinc; catalytic SRHMM633528-3 H Zinc; catalytic 1 PIRSR633528-4 Domain

IPR033528 Eukaryota

SRHMM633528-4 Y Transition state stabilizer 1 PIRSR633528-5 Domain

IPR033528 Eukaryota

SRHMM633528-5 FTGRP_1 SRHMM633528-5 FTGRP_2 Disulfide bond SRHMM633528-5 C-x(6)-C SRHMM633528-5 C-x(38)-C 1 PIRSR633528-6 Domain

IPR033528 Eukaryota

SRHMM633528-6 FTGRP_1 SRHMM633528-6 FTGRP_2 SRHMM633528-6 FTGRP_3 SRHMM633528-6 FTGRP_4 SRHMM633528-6 FTGRP_5 Glycoprotein SRHMM633528-6 N-x-T N-linked (GlcNAc...) asparagine SRHMM633528-6 N-x-T N-linked (GlcNAc...) asparagine SRHMM633528-6 N-x-[ST] N-linked (GlcNAc...) asparagine SRHMM633528-6 N-x-[TS] N-linked (GlcNAc...) asparagine SRHMM633528-6 N-x-[TS] N-linked (GlcNAc...) asparagine 1 PIRSR633560-50 Domain

IPR033560 Vertebrata

SRHMM633560-50 S Acyl-ester intermediate D Charge relay system H Charge relay system 1 PIRSR633560-51 Domain

IPR033560 Vertebrata

SRHMM633560-51 FTGRP_1 Disulfide bond SRHMM633560-51 C-x(15)-C C-x(10)-C 1 PIRSR633567-1 Domain

IPR033567 Eukaryota

SRHMM633567-1 C C 1 PIRSR633567-2 Domain

IPR033567 Eukaryota

SRHMM633567-2 FTGRP_1 SRHMM633567-2 FTGRP_2 SRHMM633567-2 FTGRP_3 SRHMM633567-2 FTGRP_4 SRHMM633567-2 FTGRP_5 Disulfide bond SRHMM633567-2 C-x(14)-C SRHMM633567-2 C-x(12)-C SRHMM633567-2 C-x(20)-C SRHMM633567-2 C-x(8)-C SRHMM633567-2 C-x(80)-C 1 PIRSR633573-1 Domain

IPR033573 Eukaryota

SRHMM633573-1 D Proton acceptor 1 PIRSR633697-1 Domain

IPR033697 Eukaryota

SRHMM633697-1 H E H 1 PIRSR633865-1 Domain

IPR033865 Eukaryota

SRHMM633865-1 C Nucleophile H Proton acceptor N 1 PIRSR634015-1 Domain

IPR034015 Eukaryota Bacteria

SRHMM634015-1 E Proton acceptor Y Proton donor 1 PIRSR634015-2 Domain

IPR034015 Eukaryota Bacteria

SRHMM634015-2 [QE]-x-[QE] Substrate binding P-x(4)-E Substrate binding [RK]-x-K Substrate binding 1 PIRSR634015-3 Domain

IPR034015 Eukaryota Bacteria

SRHMM634015-3 FTGRP_1 SRHMM634015-3 FTGRP_2 SRHMM634015-3 FTGRP_3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. SRHMM634015-3 H Zinc; catalytic SRHMM634015-3 H Zinc; catalytic SRHMM634015-3 E Zinc; catalytic 1 PIRSR634178-1 Domain

IPR034178 Eukaryota Bacteria

SRHMM634178-1 E Proton acceptor 1 PIRSR634180-1 Domain

IPR034180 Eukaryota

SRHMM634180-1 E Proton acceptor 1 PIRSR634180-2 Domain

IPR034180 Eukaryota

SRHMM634180-2 S Substrate; via carbonyl oxygen N Substrate D-x(2)-R Substrate binding G Substrate; via amide nitrogen R Substrate 1 PIRSR634180-3 Domain

IPR034180 Eukaryota

SRHMM634180-3 FTGRP_1 SRHMM634180-3 FTGRP_2 SRHMM634180-3 FTGRP_3 SRHMM634180-3 FTGRP_4 SRHMM634180-3 FTGRP_5 SRHMM634180-3 FTGRP_6 FAD FAD SRHMM634180-3 W-x-T FAD SRHMM634180-3 Q-x(3)-G FAD SRHMM634180-3 H-Q FAD SRHMM634180-3 Y-x(8)-S FAD SRHMM634180-3 T-x-Q FAD SRHMM634180-3 R-x-T FAD 1 PIRSR634183-1 Domain

IPR034183 Eukaryota Bacteria

SRHMM634183-1 E Proton acceptor 1 PIRSR634183-2 Domain

IPR034183 Eukaryota Bacteria

SRHMM634183-2 S-[RK] Substrate binding SRHMM634183-2 S Substrate; via carbonyl oxygen SRHMM634183-2 D-x(2)-R Substrate binding SRHMM634183-2 Y Substrate SRHMM634183-2 [AG]-G Substrate binding 1 PIRSR634183-3 Domain

IPR034183 Eukaryota Bacteria

SRHMM634183-3 FTGRP_1 SRHMM634183-3 FTGRP_2 SRHMM634183-3 FTGRP_3 SRHMM634183-3 FTGRP_4 SRHMM634183-3 FTGRP_5 SRHMM634183-3 FTGRP_6 FAD FAD SRHMM634183-3 R FAD SRHMM634183-3 L-x(8)-S FAD SRHMM634183-3 Q-x(3)-G FAD SRHMM634183-3 Q FAD SRHMM634183-3 W-x-T FAD SRHMM634183-3 T-x-E FAD 1 PIRSR634598-1 Domain

IPR034598 Bacteria

SRHMM634598-1 K Proton acceptor H Proton acceptor 1 PIRSR634598-2 Domain

IPR034598 Bacteria

SRHMM634598-2 H Substrate T Substrate Y Substrate K Substrate D-x-N Substrate binding N Substrate H-x-N Substrate binding H Substrate R Substrate 1 PIRSR634598-3 Domain

IPR034598 Bacteria

SRHMM634598-3 FTGRP_1 Magnesium Metal-binding Mg(2+) SRHMM634598-3 D Magnesium E Magnesium N Magnesium 1 PIRSR634603-1 Domain

IPR034603 Eukaryota Bacteria

SRHMM634603-1 K Proton acceptor; specific for (R)-substrate epimerization K Proton acceptor; specific for (S)-substrate epimerization 1 PIRSR634603-2 Domain

IPR034603 Eukaryota Bacteria

SRHMM634603-2 R Substrate [TS] Substrate K Substrate [SC] Substrate; via carbonyl oxygen [ILVM] Substrate; via amide nitrogen D Substrate D Substrate 1 PIRSR634603-3 Domain

IPR034603 Eukaryota Bacteria

SRHMM634603-3 FTGRP_1 SRHMM634603-3 FTGRP_2 SRHMM634603-3 FTGRP_3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. SRHMM634603-3 D Magnesium SRHMM634603-3 E Magnesium SRHMM634603-3 D Magnesium 1 PIRSR635711-50 Domain

IPR035711 Lepidosauria

SRHMM635711-50 FTGRP_1 Magnesium Metal-binding SRHMM635711-50 P Magnesium; via carbonyl oxygen D Magnesium V Magnesium; via carbonyl oxygen D Magnesium 1 PIRSR635711-51 Domain

IPR035711 Vertebrata

SRHMM635711-51 FTGRP_1 Thioester bond SRHMM635711-51 C-x(2)-Q Isoglutamyl cysteine thioester (Cys-Gln) 1 PIRSR635711-52 Domain

IPR035711 Vertebrata

SRHMM635711-52 FTGRP_1 Disulfide bond SRHMM635711-52 C-x(256)-C Interchain (between beta and alpha chains) C-x(34)-C C-x(26)-C C-x(32)-C C-x(20)-C C-x(639)-C C-x(56)-C C-x(130)-C C-x(68)-C C-x(4)-C C-x(71)-C C-x(123)-C C-x(8)-C 1 PIRSR637571-50 Domain

IPR037571 Vertebrata

SRHMM637571-50 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR637571-51 Domain

IPR037571 Vertebrata

SRHMM637571-51 FTGRP_1 Metal-binding Calcium SRHMM637571-51 E Calcium 1 D Calcium 1 D Calcium 1 S Calcium 1; via carbonyl oxygen N Calcium 1 D Calcium 2 [IVF] Calcium 2; via carbonyl oxygen E Calcium 2 N Calcium 2 [HY] Calcium 2; via carbonyl oxygen [GS] Calcium 2; via carbonyl oxygen 1 PIRSR637571-53 Domain

IPR037571 Vertebrata

SRHMM637571-53 FTGRP_1 Disulfide bond SRHMM637571-53 C-x(17)-C C-x(13)-C C-x(12)-C C-x(12)-C C-x(26)-C C-x(17)-C C-x(47)-C C-x(32)-C C-x(45)-C C-x(33)-C C-x(117)-C Interchain (between A and B chains) C-x(19)-C C-x(30)-C 1 PIRSR637641-50 Domain

IPR037641 Vertebrata

SRHMM637641-50 FTGRP_1 Disulfide bond SRHMM637641-50 C-x(10)-C C-x(15)-C C-x(34)-C C-x(21)-C C-x(36)-C C-x(109)-C C-x(15)-C 1 PIRSR638639-50 Domain

IPR038639 Bacteria

SRHMM638639-50 D H Proton acceptor S Nucleophile 1 PIRSR638639-51 Domain

IPR038639 Bacteria

SRHMM638639-51 FTGRP_1 Disulfide bond SRHMM638639-51 C-x(184)-C C-x(112)-C 1 PIRSR639036-50 Domain

IPR039036 Mammalia

SRHMM639036-50 FTGRP_1 Disulfide bond SRHMM639036-50 C-x(12)-C C-x(15)-C C-x(11)-C C-x(15)-C C-x(16)-C C-x(13)-C C-x(12)-C C-x(12)-C C-x(11)-C C-x(15)-C C-x(12)-C C-x(11)-C 1 PIRSR639314-50 Domain

IPR039314 Viridiplantae

SRHMM639314-50 FTGRP_1 Disulfide bond SRHMM639314-50 C-x(8)-C C-x(8)-C 1 PIRSR639901-1 Domain

IPR039901 Eukaryota Bacteria

SRHMM639901-1 E Proton acceptor 1 PIRSR639901-2 Domain

IPR039901 Eukaryota Bacteria

SRHMM639901-2 E Transition state stabilizer K Transition state stabilizer 1 PIRSR640198-1 Domain

IPR040198 Eukaryota Bacteria

SRHMM640198-1 H 1 PIRSR640198-2 Domain

IPR040198 Eukaryota Bacteria

SRHMM640198-2 FTGRP_1 SRHMM640198-2 FTGRP_2 SRHMM640198-2 FTGRP_3 SRHMM640198-2 FTGRP_4 ATP-binding Nucleotide-binding SRHMM640198-2 V-x(2)-H ATP SRHMM640198-2 Y-Y ATP SRHMM640198-2 N ATP SRHMM640198-2 D-x(6)-R ATP 1 PIRSR640198-3 Domain

IPR040198 Eukaryota Bacteria

SRHMM640198-3 E Important for autoinhibition of adenylyltransferase activity 1 PIRSR640198-4 Domain

IPR040198 Eukaryota Bacteria

SRHMM640198-4 N-x-[TS] N-linked (GlcNAc...) asparagine