1 PIRSR000005-1 Domain

PIRSF000005 Bacteria

SRHMM000005-1 Heme Binds 2 heme groups per subunit. C Heme 1 (covalent) C Heme 1 (covalent) C Heme 2 (covalent) C Heme 2 (covalent) 1 PIRSR000005-2 Domain

PIRSF000005 Bacteria

SRHMM000005-2 Iron Metal-binding Binds 2 heme groups per subunit. H Iron (heme 1 axial ligand) M Iron (heme 1 axial ligand) H Iron (heme 2 axial ligand) M Iron (heme 2 axial ligand) 1 PIRSR000006-1 Domain

PIRSF000006 Bacteria

SRHMM000006-1 Iron Metal-binding H Iron (heme C 1 axial ligand) M Iron (heme C 2 axial ligand) H Iron (heme C 2 axial ligand) M Iron (heme C 1 axial ligand) 1 PIRSR000006-2 Domain

PIRSF000006 Bacteria

SRHMM000006-2 Heme heme c Binds 2 heme C groups per subunit. C Heme C 1 (covalent) C Heme C 1 (covalent) C Heme C 2 (covalent) C Heme C 2 (covalent) 1 PIRSR000007-50 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF000007 Bacteria

SRHMM000007-50 Heme Binds 2 heme groups per subunit. C Heme 1 (covalent) C Heme 1 (covalent) C Heme 2 (covalent) C Heme 2 (covalent) 1 PIRSR000007-51 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF000007 Bacteria

SRHMM000007-51 Heme Iron Metal-binding Binds 2 heme groups per subunit. H Iron (heme 1 axial ligand) H Iron (heme 2 axial ligand) 1 PIRSR000008-1 Domain

PIRSF000008 Bacteria

SRHMM000008-1 Heme Binds 1 heme group per subunit. C Heme (covalent) SRHMM000008-1 Heme Binds 1 heme group per subunit. C Heme (covalent) 1 PIRSR000008-2 Domain

PIRSF000008 Bacteria

SRHMM000008-2 Iron Metal-binding H Iron (heme axial ligand) 1 PIRSR000014-1 Domain

PIRSF000014 Bacteria

SRHMM000014-1 Heme Binds 5 heme groups per subunit. C Heme 1 (covalent) C Heme 1 (covalent) C Heme 2 (covalent) C Heme 2 (covalent) C Heme 3 (covalent) C Heme 3 (covalent) C Heme 4 (covalent) C Heme 4 (covalent) C Heme 5 (covalent) C Heme 5 (covalent) 1 PIRSR000014-2 Domain

PIRSF000014 Bacteria

SRHMM000014-2 Iron H Iron (heme 2 axial ligand) SRHMM000014-2 Iron H Iron (heme 3 axial ligand) SRHMM000014-2 Iron H Iron (heme 1 axial ligand) SRHMM000014-2 Iron H Iron (heme 4 axial ligand) SRHMM000014-2 Iron H Iron (heme 5 axial ligand) 1 PIRSR000017-1 Domain

PIRSF000017 Bacteria

SRHMM000017-1 Heme C Heme 1 (covalent) SRHMM000017-1 Heme C Heme 2 (covalent) SRHMM000017-1 Heme C Heme 4 (covalent) SRHMM000017-1 Heme C Heme 1 (covalent) SRHMM000017-1 Heme C Heme 2 (covalent) SRHMM000017-1 Heme C Heme 3 (covalent) SRHMM000017-1 Heme C Heme 3 (covalent) SRHMM000017-1 Heme C Heme 4 (covalent) 1 PIRSR000017-2 Domain

PIRSF000017 Bacteria

SRHMM000017-2 Iron Metal-binding Binds 4 heme groups per subunit. H Iron (heme 2 axial ligand) SRHMM000017-2 Iron Metal-binding Binds 4 heme groups per subunit. H Iron (heme 4 axial ligand) SRHMM000017-2 Iron Metal-binding Binds 4 heme groups per subunit. M Iron (heme 3 axial ligand) SRHMM000017-2 Iron Metal-binding Binds 4 heme groups per subunit. H Iron (heme 1 axial ligand) SRHMM000017-2 Iron Metal-binding Binds 4 heme groups per subunit. H Iron (heme 4 axial ligand) SRHMM000017-2 Iron Metal-binding Binds 4 heme groups per subunit. M Iron (heme 1 axial ligand) SRHMM000017-2 Iron Metal-binding Binds 4 heme groups per subunit. M Iron (heme 2 axial ligand) SRHMM000017-2 Iron Metal-binding Binds 4 heme groups per subunit. H Iron (heme 3 axial ligand) 1 PIRSR000018-50 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF000018 Bacteria

SRHMM000018-50 Heme Binds 3 heme groups per subunit. C Heme 1 (covalent) C Heme 1 (covalent) C Heme 2 (covalent) C Heme 2 (covalent) C Heme 3 (covalent) C Heme 3 (covalent) 1 PIRSR000018-51 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF000018 Bacteria

SRHMM000018-51 Heme Iron Metal-binding Binds 3 heme groups per subunit. H Iron (heme 1 axial ligand) H Iron (heme 2 axial ligand) H Iron (heme 3 axial ligand) 1 PIRSR000019-1 Domain

PIRSF000019 Eukaryota

SRHMM000019-1 Disulfide bond C-x(43)-C SRHMM000019-1 C-x(13)-C 1 PIRSR000025-1 Domain

PIRSF000025 Bacteria

SRHMM000025-1 Heme Binds 1 heme group per subunit. C Heme (covalent) SRHMM000025-1 Heme Binds 1 heme group per subunit. C Heme (covalent) 1 PIRSR000025-2 Domain

PIRSF000025 Bacteria

SRHMM000025-2 Iron Metal-binding H Iron (heme axial ligand) SRHMM000025-2 Iron Metal-binding M Iron (heme axial ligand) 1 PIRSR000027-1 Domain

PIRSF000027 Bacteria

SRHMM000027-1 Metal-binding Iron H Iron (heme axial ligand) 1 PIRSR000027-2 Domain

PIRSF000027 Bacteria

SRHMM000027-2 Heme C Heme (covalent) C Heme (covalent) 1 PIRSR000029-1 Domain

PIRSF000029 Bacteria

SRHMM000029-1 Heme Iron Metal-binding heme b Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule. M Iron (heme B axial ligand) SRHMM000029-1 Heme Iron Metal-binding heme b Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule. H Iron (heme B axial ligand) 1 PIRSR000047-1 Domain

PIRSF000047 Eukaryota

SRHMM000047-1 Heme Iron Metal-binding heme C Iron (heme axial ligand) 1 PIRSR000068-1 Domain

PIRSF000068 Archaea

SRHMM000068-1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion. H Zinc SRHMM000068-1 Metal-binding 3Fe-4S Iron-sulfur Iron [3Fe-4S] cluster Binds 1 [3Fe-4S] cluster. C Iron-sulfur 1 (3Fe-4S) SRHMM000068-1 Metal-binding 4Fe-4S Iron-sulfur Iron [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. C Iron-sulfur 2 (4Fe-4S) SRHMM000068-1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion. D Zinc SRHMM000068-1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion. H Zinc SRHMM000068-1 Metal-binding 3Fe-4S Iron-sulfur Iron [3Fe-4S] cluster Binds 1 [3Fe-4S] cluster. C Iron-sulfur 1 (3Fe-4S) SRHMM000068-1 Metal-binding 3Fe-4S Iron-sulfur Iron [3Fe-4S] cluster Binds 1 [3Fe-4S] cluster. C Iron-sulfur 1 (3Fe-4S) SRHMM000068-1 Metal-binding 4Fe-4S Iron-sulfur Iron [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. C Iron-sulfur 2 (4Fe-4S) SRHMM000068-1 Metal-binding 4Fe-4S Iron-sulfur Iron [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. C Iron-sulfur 2 (4Fe-4S) SRHMM000068-1 Metal-binding 4Fe-4S Iron-sulfur Iron [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. C Iron-sulfur 2 (4Fe-4S) SRHMM000068-1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion. H Zinc 1 PIRSR000071-1 Domain

PIRSF000071 Archaea Bacteria

SRHMM000071-1 Iron Metal-binding Fe(3+) Binds 1 Fe(3+) ion per subunit. C Iron SRHMM000071-1 Iron Metal-binding Fe(3+) Binds 1 Fe(3+) ion per subunit. C Iron SRHMM000071-1 Iron Metal-binding Fe(3+) Binds 1 Fe(3+) ion per subunit. C Iron SRHMM000071-1 Iron Metal-binding Fe(3+) Binds 1 Fe(3+) ion per subunit. C Iron 1 PIRSR000077-4 Domain

PIRSF000077 Archaea Eukaryota Bacteria

SRHMM000077-4 C-x(2)-C Redox-active 1 PIRSR000087-50 Domain This rule was created based on analysis for RESID:AA0207.

PIRSF000087 Proteobacteria

SRHMM000087-50 Chromophore The 4-hydroxycinnamic acid (p-coumaric acid) chromophore is covalently bound via a thioester linkage. C S-(4-hydroxycinnamyl)cysteine 1 PIRSR000094-1 Domain

PIRSF000094 Bacteria

SRHMM000094-1 Y Proton acceptor Y Proton acceptor 1 PIRSR000094-2 Domain

PIRSF000094 Bacteria

SRHMM000094-2 A Substrate; via amide nitrogen and carbonyl oxygen 1 PIRSR000094-4 Domain

PIRSF000094 Bacteria

SRHMM000094-4 K Involved in acyl-ACP binding [RKN] Involved in acyl-ACP binding K Involved in acyl-ACP binding 1 PIRSR000095-1 Domain

PIRSF000095 Eukaryota

SRHMM000095-1 Y Proton acceptor 1 PIRSR000095-2 Domain

PIRSF000095 Eukaryota

SRHMM000095-2 S Substrate 1 PIRSR000097-1 Domain

PIRSF000097 Eukaryota Bacteria

SRHMM000097-1 Y Proton donor 1 PIRSR000098-1 Domain

PIRSF000098 Bacteria

SRHMM000098-1 K Proton donor 1 PIRSR000098-2 Domain

PIRSF000098 Bacteria

SRHMM000098-2 NADP K NADP SRHMM000098-2 NADP [LVIMAC]-G-x-G-x(2)-G-[STGAKC] NADP SRHMM000098-2 E Substrate 1 PIRSR000099-1 Domain

PIRSF000099 Archaea Viridiplantae Fungi Bacteria

SRHMM000099-1 E Proton acceptor H Proton acceptor 1 PIRSR000099-2 Domain

PIRSF000099 Archaea Viridiplantae Fungi Bacteria

SRHMM000099-2 NAD Y NAD Q NAD N NAD 1 PIRSR000099-3 Domain

PIRSF000099 Archaea Viridiplantae Fungi Bacteria

SRHMM000099-3 [ST] Substrate Q Substrate H Substrate H Substrate D Substrate E Substrate H Substrate 1 PIRSR000099-4 Domain

PIRSF000099 Archaea Viridiplantae Fungi Bacteria

SRHMM000099-4 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. [QE] Zinc H Zinc D Zinc H Zinc 1 PIRSR000103-1 Domain

PIRSF000103 Eukaryota Bacteria

SRHMM000103-1 K 1 PIRSR000103-2 Domain

PIRSF000103 Eukaryota Bacteria

SRHMM000103-2 NAD T-x(27)-Y NAD L-P NAD N NAD T NAD K NAD 1 PIRSR000105-1 Domain

PIRSF000105 Eukaryota Bacteria

SRHMM000105-1 H Important for catalytic activity 1 PIRSR000105-3 Domain

PIRSF000105 Eukaryota Bacteria

SRHMM000105-3 S Coenzyme A K Coenzyme A S Coenzyme A 1 PIRSR000106-1 Domain

PIRSF000106 Eukaryota Bacteria

SRHMM000106-1 Y Proton donor K Proton acceptor 1 PIRSR000106-3 Domain

PIRSF000106 Eukaryota Bacteria

SRHMM000106-3 Metal-binding Mg(2+) Mn(2+) Divalent metal cations. Prefers magnesium or manganese. D Divalent metal cation SRHMM000106-3 Metal-binding Mg(2+) Mn(2+) Divalent metal cations. Prefers magnesium or manganese. E Divalent metal cation SRHMM000106-3 Metal-binding Mg(2+) Mn(2+) Divalent metal cations. Prefers magnesium or manganese. D Divalent metal cation 1 PIRSR000108-1 Domain

PIRSF000108 Eukaryota Bacteria

SRHMM000108-1 Y Critical for catalysis K Critical for catalysis 1 PIRSR000108-2 Domain

PIRSF000108 Eukaryota Bacteria

SRHMM000108-2 T Substrate S-x-N-x(3)-R Substrate binding R Substrate R Substrate 1 PIRSR000108-3 Domain

PIRSF000108 Eukaryota Bacteria

SRHMM000108-3 Manganese Metal-binding Magnesium Mg(2+) Mn(2+) Binds 1 Mg(2+) or Mn(2+) ion per subunit. D Magnesium or manganese D Magnesium or manganese 1 PIRSR000108-4 Domain

PIRSF000108 Eukaryota Bacteria

SRHMM000108-4 NADP T-x-T NADP R NADP K NADP G-T-V-x-R-H NADP N NADP; via amide nitrogen and carbonyl oxygen 1 PIRSR000109-1 Domain

PIRSF000109 Eukaryota Bacteria

SRHMM000109-1 K Proton acceptor E Proton donor 1 PIRSR000109-2 Domain

PIRSF000109 Eukaryota Bacteria

SRHMM000109-2 N Substrate S-x-G Substrate binding H-N Substrate binding Y Substrate K Substrate; via amide nitrogen R Substrate R Substrate; shared with dimeric partner H Substrate; shared with dimeric partner 1 PIRSR000109-3 Domain

PIRSF000109 Eukaryota Bacteria

SRHMM000109-3 G-x(4)-G NADP N-x-[ST] NADP [VI]-x-[AG] NADP N NADP 1 PIRSR000112-1 Domain

PIRSF000112 Archaea Bacteria

SRHMM000112-1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. [DE] Zinc; catalytic SRHMM000112-1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. H Zinc; catalytic SRHMM000112-1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. H Zinc; catalytic 1 PIRSR000114-1 Domain

PIRSF000114 Archaea Eukaryota Bacteria

SRHMM000114-1 K Proton acceptor 1 PIRSR000114-2 Domain

PIRSF000114 Archaea Eukaryota Bacteria

SRHMM000114-2 K Substrate R-N Substrate binding 1 PIRSR000118-1 Domain

PIRSF000118 Eukaryota

SRHMM000118-1 H 1 PIRSR000118-2 Domain

PIRSF000118 Eukaryota

SRHMM000118-2 Magnesium Metal-binding E Magnesium 1 SRHMM000118-2 Magnesium Metal-binding D Magnesium 1 D Magnesium 2 1 PIRSR000118-3 Domain

PIRSF000118 Eukaryota Bacteria

SRHMM000118-3 Magnesium Metal-binding D Magnesium 2 1 PIRSR000130-1 Domain

PIRSF000130 Archaea Eukaryota Bacteria

SRHMM000130-1 C Thioimidate intermediate 1 PIRSR000138-1 Domain

PIRSF000138 Eukaryota Bacteria

SRHMM000138-1 H Proton acceptor 1 PIRSR000148-1 Domain

PIRSF000148 Archaea Eukaryota Bacteria

SRHMM000148-1 C Acyl-thioester intermediate H Proton acceptor 1 PIRSR000149-1 Domain

PIRSF000149 Archaea Eukaryota Bacteria

SRHMM000149-1 C Nucleophile 1 PIRSR000149-4 Domain

PIRSF000149 Archaea Eukaryota Bacteria

SRHMM000149-4 H Activates thiol group during catalysis 1 PIRSR000159-50 Domain This rule was created based on analysis for RESID:AA0140.

PIRSF000159 Eukaryota Bacteria

SRHMM000159-50 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 3 [4Fe-4S] clusters per subunit. C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) 1 PIRSR000167-1 Domain

PIRSF000167 Bacteria

SRHMM000167-1 S-adenosyl-L-methionine G-[TS] S-adenosyl-L-methionine 2 binding SRHMM000167-1 S-adenosyl-L-methionine Y S-adenosyl-L-methionine 1 SRHMM000167-1 S-adenosyl-L-methionine D S-adenosyl-L-methionine 2 SRHMM000167-1 S-adenosyl-L-methionine R S-adenosyl-L-methionine 2 SRHMM000167-1 S-adenosyl-L-methionine [FY] S-adenosyl-L-methionine 2; via carbonyl oxygen SRHMM000167-1 S-adenosyl-L-methionine G S-adenosyl-L-methionine 1; via amide nitrogen and carbonyl oxygen SRHMM000167-1 S-adenosyl-L-methionine Q S-adenosyl-L-methionine 2 SRHMM000167-1 S-adenosyl-L-methionine E S-adenosyl-L-methionine 1 1 PIRSR000167-2 Domain

PIRSF000167 Bacteria

SRHMM000167-2 4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM000167-2 4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM000167-2 4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. C Iron-sulfur (4Fe-4S-S-AdoMet) 1 PIRSR000169-1 Domain

PIRSF000169 Bacteria

SRHMM000169-1 Y Ubiquinone 1 PIRSR000169-2 Domain

PIRSF000169 Bacteria

SRHMM000169-2 Heme Iron Metal-binding heme The heme is bound between the two transmembrane subunits. H Iron (heme axial ligand); shared with second transmembrane subunit 1 PIRSR000177-1 Domain

PIRSF000177 Bacteria

SRHMM000177-1 Heme Iron Metal-binding H Iron (heme axial ligand) H Iron (heme axial ligand) H Iron (heme axial ligand) H Iron (heme axial ligand) 1 PIRSR000190-1 Domain

PIRSF000190 Eukaryota Bacteria

SRHMM000190-1 R-x(2)-Y Substrate binding [KR] Substrate Y Substrate R Substrate S Substrate R-x-[HN] Substrate binding 1 PIRSR000190-2 Domain

PIRSF000190 Eukaryota Bacteria

SRHMM000190-2 FMN FMN Binds 1 FMN per subunit. Q-S FMN SRHMM000190-2 FMN FMN Binds 1 FMN per subunit. K FMN SRHMM000190-2 FMN FMN Binds 1 FMN per subunit. [YF]-[TS] FMN SRHMM000190-2 FMN FMN Binds 1 FMN per subunit. R FMN SRHMM000190-2 FMN FMN Binds 1 FMN per subunit. [LV] FMN; via amide nitrogen 1 PIRSR000194-1 Domain

PIRSF000194 Bacteria

SRHMM000194-1 I Substrate; via carbonyl oxygen A NADP; via amide nitrogen and carbonyl oxygen V-x(5)-A NADP D Substrate H-T NADP R Substrate R Substrate S-S NADP K NADP; via carbonyl oxygen G-x(6)-Q NADP T Substrate 1 PIRSR000197-1 Domain

PIRSF000197 Bacteria

SRHMM000197-1 E C 1 PIRSR000207-1 Domain

PIRSF000207 Bacteria

SRHMM000207-1 FMN FMN Binds 1 FMN per subunit. S-T-x(3)-G FMN SRHMM000207-1 NADP S-x(5)-K-x-Y NADP SRHMM000207-1 FAD FAD Binds 1 FAD per subunit. G-x-S FAD SRHMM000207-1 FAD FAD Binds 1 FAD per subunit. R-x-Y-S FAD SRHMM000207-1 NADP N NADP SRHMM000207-1 FMN FMN Binds 1 FMN per subunit. V-x(30)-L FMN SRHMM000207-1 FMN FMN Binds 1 FMN per subunit. S-x-T-x-N FMN 1 PIRSR000209-1 Domain

PIRSF000209 Eukaryota Bacteria

SRHMM000209-1 Heme Iron Metal-binding heme C Iron (heme axial ligand) 1 PIRSR000216-1 Domain

PIRSF000216 Eukaryota Bacteria

SRHMM000216-1 2Fe-2S Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster. C Iron-sulfur (2Fe-2S) C Iron-sulfur (2Fe-2S) C Iron-sulfur (2Fe-2S) C Iron-sulfur (2Fe-2S) 1 PIRSR000232-1 Domain

PIRSF000232 Bacteria

SRHMM000232-1 FMN FMN Binds 1 FMN per subunit. R FMN; shared with dimeric partner SRHMM000232-1 FMN FMN Binds 1 FMN per subunit. [HA] FMN; shared with dimeric partner SRHMM000232-1 FMN FMN Binds 1 FMN per subunit. [WLM]-x-[STLG] FMN SRHMM000232-1 FMN FMN Binds 1 FMN per subunit. R-x-[ST] FMN 1 PIRSR000235-1 Domain

PIRSF000235 Eukaryota Bacteria

SRHMM000235-1 C Thioimidate intermediate 1 PIRSR000235-3 Domain

PIRSF000235 Eukaryota Bacteria

SRHMM000235-3 Metal-binding Potassium G Potassium; via carbonyl oxygen SRHMM000235-3 Metal-binding Potassium G Potassium; via carbonyl oxygen 1 PIRSR000238-1 Domain

PIRSF000238 Bacteria

SRHMM000238-1 NAD NADP [RDHKE]-x(13)-A NAD or NADP SRHMM000238-1 FAD FAD Binds 1 FAD per subunit. T-x(9)-D FAD SRHMM000238-1 FAD FAD Binds 1 FAD per subunit. [DE]-x(14)-[IVL] FAD 1 PIRSR000238-2 Domain

PIRSF000238 Bacteria

SRHMM000238-2 Disulfide bond Redox-active center C-x(2)-C Redox-active 1 PIRSR000241-1 Domain

PIRSF000241 Archaea Eukaryota Bacteria

SRHMM000241-1 R Charge relay system Q Charge relay system 1 PIRSR000241-2 Domain

PIRSF000241 Archaea Eukaryota Bacteria

SRHMM000241-2 R Substrate [VIL]-Q Substrate binding 1 PIRSR000260-1 Domain

PIRSF000260 Eukaryota Bacteria

SRHMM000260-1 C Nucleophile 1 PIRSR000260-2 Domain

PIRSF000260 Eukaryota Bacteria

SRHMM000260-2 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. C Iron-sulfur (4Fe-4S) SRHMM000260-2 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. C Iron-sulfur (4Fe-4S) SRHMM000260-2 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. C Iron-sulfur (4Fe-4S) SRHMM000260-2 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. C Iron-sulfur (4Fe-4S) 1 PIRSR000260-3 Domain

PIRSF000260 Eukaryota Bacteria

SRHMM000260-3 H Increases the nucleophilicity of the active site Cys 1 PIRSR000260-4 Domain

PIRSF000260 Eukaryota Bacteria

SRHMM000260-4 Disulfide bond C-x(29)-C Redox-active 1 PIRSR000262-1 Domain

PIRSF000262 Archaea

SRHMM000262-1 Metal-binding Nickel Q Nickel 1 PIRSR000262-2 Domain

PIRSF000262 Archaea

SRHMM000262-2 Metal-binding Nickel H Pros-methylhistidine R 5-methylarginine 1 PIRSR000278-1 Domain

PIRSF000278 Eukaryota

SRHMM000278-1 Disulfide bond C-x(13)-C SRHMM000278-1 Disulfide bond C-x(34)-C 1 PIRSR000290-1 Domain

PIRSF000290 Eukaryota

SRHMM000290-1 Copper Metal-binding Cu(2+) Binds 2 copper ions per subunit. H Copper A SRHMM000290-1 Copper Metal-binding Cu(2+) Binds 2 copper ions per subunit. H Copper A SRHMM000290-1 Copper Metal-binding Cu(2+) Binds 2 copper ions per subunit. H Copper A SRHMM000290-1 Copper Metal-binding Cu(2+) Binds 2 copper ions per subunit. H Copper B SRHMM000290-1 Copper Metal-binding Cu(2+) Binds 2 copper ions per subunit. H Copper B SRHMM000290-1 Copper Metal-binding Cu(2+) Binds 2 copper ions per subunit. H Copper B 1 PIRSR000290-2 Domain

PIRSF000290 Eukaryota

SRHMM000290-2 Disulfide bond C-x(14)-C SRHMM000290-2 Disulfide bond C-x(62)-C 1 PIRSR000290-3 Domain

PIRSF000290 Eukaryota

SRHMM000290-3 C-x(16)-H 2'-(S-cysteinyl)-histidine (Cys-His) 1 PIRSR000294-1 Domain

PIRSF000294 Bacteria

SRHMM000294-1 Heme Binds 2 heme groups per subunit. C Heme 2 (covalent) SRHMM000294-1 Heme Binds 2 heme groups per subunit. C Heme 1 (covalent) SRHMM000294-1 Heme Binds 2 heme groups per subunit. C Heme 2 (covalent) SRHMM000294-1 Heme Binds 2 heme groups per subunit. C Heme 1 (covalent) 1 PIRSR000294-2 Domain

PIRSF000294 Bacteria

SRHMM000294-2 Iron Metal-binding heme Binds 2 heme groups. H Iron (heme 1 axial ligand) SRHMM000294-2 Iron Metal-binding heme Binds 2 heme groups. H Iron (heme 2 axial ligand) SRHMM000294-2 Iron Metal-binding heme Binds 2 heme groups. H Iron (heme 1 axial ligand) SRHMM000294-2 Iron Metal-binding heme Binds 2 heme groups. M Iron (heme 2 axial ligand) 1 PIRSR000296-1 Domain

PIRSF000296 Bacteria

SRHMM000296-1 H 1 PIRSR000296-2 Domain

PIRSF000296 Bacteria

SRHMM000296-2 Heme Iron Metal-binding Y Iron (heme axial ligand) 1 PIRSR000310-1 Domain

PIRSF000310 Bacteria

SRHMM000310-1 3Fe-4S 4Fe-4S Iron Iron-sulfur Metal-binding [3Fe-4S] cluster Binds 1 [3Fe-4S] cluster. [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) H Iron-sulfur 2 (4Fe-4S); via pros nitrogen C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 3 (3Fe-4S) C Iron-sulfur 3 (3Fe-4S) C Iron-sulfur 3 (3Fe-4S) 1 PIRSR000331-1 Domain

PIRSF000331 Bacteria

SRHMM000331-1 R-x(3)-Y Substrate binding H Substrate S-T Substrate binding 1 PIRSR000331-2 Domain

PIRSF000331 Bacteria

SRHMM000331-2 FAD Q-x(2)-R FAD SRHMM000331-2 FAD T FAD SRHMM000331-2 FAD D-x(2)-R FAD SRHMM000331-2 FAD H-x-[LIVM] FAD 1 PIRSR000336-1 Domain

PIRSF000336 Eukaryota

SRHMM000336-1 Iron Metal-binding Fe(2+) H Iron SRHMM000336-1 Iron Metal-binding Fe(2+) E Iron SRHMM000336-1 Iron Metal-binding Fe(2+) H Iron 1 PIRSR000337-1 Domain

PIRSF000337 Bacteria

SRHMM000337-1 FMN FMN H-x(3)-Y FMN binding SRHMM000337-1 FMN FMN T FMN SRHMM000337-1 FMN FMN D FMN; via amide nitrogen and carbonyl oxygen SRHMM000337-1 FMN FMN A-x(2)-S FMN binding 1 PIRSR000343-2 Domain

PIRSF000343 Viruses Eukaryota Bacteria

SRHMM000343-2 Iron Metal-binding H Iron (heme axial ligand) 1 PIRSR000362-1 Domain

PIRSF000362 Eukaryota Bacteria

SRHMM000362-1 FAD FAD G-x-I FAD SRHMM000362-1 FAD FAD W FAD; via amide nitrogen SRHMM000362-1 FAD FAD [SA] FAD; via amide nitrogen SRHMM000362-1 FAD FAD L FAD; via amide nitrogen SRHMM000362-1 FAD FAD [VIL] FAD; via amide nitrogen and carbonyl oxygen SRHMM000362-1 FAD FAD E FAD 1 PIRSR000362-2 Domain

PIRSF000362 Eukaryota Bacteria

SRHMM000362-2 NADP [NQH]-x-N-V NADP SRHMM000362-2 NADP E NADP SRHMM000362-2 NADP G NADP; via amide nitrogen SRHMM000362-2 NADP R-R NADP 1 PIRSR000376-2 Domain

PIRSF000376 Archaea Bacteria

SRHMM000376-2 4Fe-4S Iron Iron-sulfur Metal-binding C Iron-sulfur (4Fe-4S) SRHMM000376-2 4Fe-4S Iron Iron-sulfur Metal-binding C Iron-sulfur (4Fe-4S) SRHMM000376-2 4Fe-4S Iron Iron-sulfur Metal-binding C Iron-sulfur (4Fe-4S) SRHMM000376-2 4Fe-4S Iron Iron-sulfur Metal-binding C Iron-sulfur (4Fe-4S) 1 PIRSR000379-1 Domain

PIRSF000379 Bacteria

SRHMM000379-1 C S-acetylcysteine intermediate C Cysteine radical intermediate 1 PIRSR000379-2 Domain

PIRSF000379 Bacteria

SRHMM000379-2 Organic radical G Glycine radical 1 PIRSR000381-1 Domain

PIRSF000381 Archaea Eukaryota Bacteria

SRHMM000381-1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. C Zinc SRHMM000381-1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. C Zinc SRHMM000381-1 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. C Zinc SRHMM000381-1 Cobalt Metal-binding H Cobalt (cobalamin axial ligand) 1 PIRSR000384-1 Domain

PIRSF000384 Eukaryota

SRHMM000384-1 S-adenosyl-L-methionine N S-adenosyl-L-methionine SRHMM000384-1 S-adenosyl-L-methionine Y S-adenosyl-L-methionine SRHMM000384-1 S-adenosyl-L-methionine D-[VA] S-adenosyl-L-methionine binding SRHMM000384-1 S-adenosyl-L-methionine Y S-adenosyl-L-methionine SRHMM000384-1 S-adenosyl-L-methionine G-[SA] S-adenosyl-L-methionine binding SRHMM000384-1 S-adenosyl-L-methionine Y S-adenosyl-L-methionine SRHMM000384-1 S-adenosyl-L-methionine D S-adenosyl-L-methionine 1 PIRSR000385-1 Domain

PIRSF000385 Eukaryota Bacteria

SRHMM000385-1 Y Substrate N Substrate R Substrate Y Substrate 1 PIRSR000385-2 Domain

PIRSF000385 Eukaryota Bacteria

SRHMM000385-2 S-adenosyl-L-methionine [ND]-W S-adenosyl-L-methionine binding SRHMM000385-2 S-adenosyl-L-methionine A S-adenosyl-L-methionine; via carbonyl oxygen SRHMM000385-2 S-adenosyl-L-methionine D S-adenosyl-L-methionine SRHMM000385-2 S-adenosyl-L-methionine [LQ] S-adenosyl-L-methionine; via carbonyl oxygen SRHMM000385-2 S-adenosyl-L-methionine Y S-adenosyl-L-methionine SRHMM000385-2 S-adenosyl-L-methionine W S-adenosyl-L-methionine SRHMM000385-2 S-adenosyl-L-methionine R S-adenosyl-L-methionine 1 PIRSR000386-1 Domain

PIRSF000386 Bacteria

SRHMM000386-1 S-adenosyl-L-methionine G S-adenosyl-L-methionine; via amide nitrogen SRHMM000386-1 S-adenosyl-L-methionine [ILMV]-G-[DEN]-[YF]-[VI]-[LIVM] S-adenosyl-L-methionine binding 1 PIRSR000388-1 Domain

PIRSF000388 Archaea Bacteria

SRHMM000388-1 [ED] Proton acceptor 1 PIRSR000388-2 Domain

PIRSF000388 Archaea Bacteria

SRHMM000388-2 D-[ST] Alpha-ketoisovalerate binding D Alpha-ketoisovalerate [KR] Alpha-ketoisovalerate 1 PIRSR000388-3 Domain

PIRSF000388 Archaea Bacteria

SRHMM000388-3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. D Magnesium SRHMM000388-3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. D Magnesium SRHMM000388-3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. E Magnesium 1 PIRSR000389-1 Domain

PIRSF000389 Eukaryota

SRHMM000389-1 C 1 PIRSR000390-1 Domain

PIRSF000390 Bacteria

SRHMM000390-1 Pyridoxal phosphate K N6-(pyridoxal phosphate)lysine 1 PIRSR000398-1 Domain

PIRSF000398 Bacteria

SRHMM000398-1 W S-adenosyl-L-methionine K S-adenosyl-L-methionine; via amide nitrogen D S-adenosyl-L-methionine D S-adenosyl-L-methionine 1 PIRSR000409-1 Domain

PIRSF000409 Bacteria

SRHMM000409-1 C Nucleophile; methyl group acceptor from phosphotriester C Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine 1 PIRSR000409-2 Domain

PIRSF000409 Bacteria

SRHMM000409-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. T DNA R DNA [RK] DNA R DNA 1 PIRSR000409-3 Domain

PIRSF000409 Bacteria

SRHMM000409-3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. C Zinc SRHMM000409-3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. C Zinc SRHMM000409-3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. C Zinc SRHMM000409-3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. C Zinc 1 PIRSR000410-1 Domain

PIRSF000410 Proteobacteria

SRHMM000410-1 S-adenosyl-L-methionine R S-adenosyl-L-methionine SRHMM000410-1 S-adenosyl-L-methionine [DE] S-adenosyl-L-methionine SRHMM000410-1 S-adenosyl-L-methionine R-N S-adenosyl-L-methionine binding SRHMM000410-1 S-adenosyl-L-methionine [ED] S-adenosyl-L-methionine SRHMM000410-1 S-adenosyl-L-methionine [ND]-[LM] S-adenosyl-L-methionine binding SRHMM000410-1 S-adenosyl-L-methionine N S-adenosyl-L-methionine SRHMM000410-1 S-adenosyl-L-methionine [TS] S-adenosyl-L-methionine 1 PIRSR000412-50 Domain This rule was created based on analysis for RESID:AA0119.

PIRSF000412 Viruses Archaea Eukaryota Bacteria

SRHMM000412-50 Pyridoxal phosphate pyridoxal 5'-phosphate K N6-(pyridoxal phosphate)lysine 1 PIRSR000429-1 Domain

PIRSF000429 Eukaryota Bacteria

SRHMM000429-1 C Acyl-thioester intermediate H Proton acceptor C Proton acceptor 1 PIRSR000429-2 Domain

PIRSF000429 Eukaryota Bacteria

SRHMM000429-2 Y Coenzyme A R-x-D Coenzyme A binding K Coenzyme A S Coenzyme A 1 PIRSR000431-2 Domain

PIRSF000431 Eukaryota

SRHMM000431-2 H-x(4)-D HXXXXD motif 1 PIRSR000440-1 Domain

PIRSF000440 Bacteria

SRHMM000440-1 H Proton acceptor 1 PIRSR000443-1 Domain

PIRSF000443 Archaea Eukaryota Bacteria

SRHMM000443-1 S Nucleophile D H 1 PIRSR000445-1 Domain

PIRSF000445 Archaea Eukaryota Bacteria

SRHMM000445-1 C Nucleophile 1 PIRSR000445-2 Domain

PIRSF000445 Archaea Eukaryota Bacteria

SRHMM000445-2 T-C-x-R Substrate binding S Substrate [ED]-x-[EDQH] Substrate binding Q Substrate 1 PIRSR000445-3 Domain

PIRSF000445 Archaea Eukaryota Bacteria

SRHMM000445-3 NADP [GA]-x-[GQ]-x(2)-[GCSAINV] NADP 1 PIRSR000445-4 Domain

PIRSF000445 Archaea Eukaryota Bacteria

SRHMM000445-4 H Important for activity 1 PIRSR000446-1 Domain

PIRSF000446 Bacteria

SRHMM000446-1 S H 1 PIRSR000447-1 Domain

PIRSF000447 Eukaryota Bacteria

SRHMM000447-1 C 1 PIRSR000450-1 Domain

PIRSF000450 Bacteria

SRHMM000450-1 C 1 PIRSR000452-1 Domain

PIRSF000452 Bacteria

SRHMM000452-1 W Substrate H Substrate Y Substrate E Substrate [ILV]-x-[VI] Acetyl-CoA binding [QR]-x(4)-[KR] Acetyl-CoA binding D Substrate N Acetyl-CoA [ED] Substrate 1 PIRSR000454-1 Domain

PIRSF000454 Fungi

SRHMM000454-1 C For beta-ketoacyl synthase activity 1 PIRSR000454-2 Domain

PIRSF000454 Fungi

SRHMM000454-2 D-x-E Acetyl-CoA binding Y Acetyl-CoA S Acetyl-CoA E-x(11)-G-x(3)-[ASPE] Acetyl-CoA binding [RVNSE]-x(2)-[KNSG] Acetyl-CoA binding I-x-H Acetyl-CoA binding 1 PIRSR000454-3 Domain

PIRSF000454 Fungi

SRHMM000454-3 Magnesium Metal-binding D Magnesium SRHMM000454-3 Magnesium Metal-binding S Magnesium SRHMM000454-3 Magnesium Metal-binding V Magnesium; via carbonyl oxygen SRHMM000454-3 Magnesium Metal-binding E Magnesium SRHMM000454-3 Magnesium Metal-binding H Magnesium; via carbonyl oxygen 1 PIRSR000454-4 Domain

PIRSF000454 Fungi

SRHMM000454-4 Phosphopantetheine S O-(pantetheine 4'-phosphoryl)serine 1 PIRSR000459-1 Domain

PIRSF000459 Eukaryota

SRHMM000459-1 C H D 1 PIRSR000460-1 Domain

PIRSF000460 Archaea Eukaryota Bacteria

SRHMM000460-1 Pyridoxal phosphate K N6-(pyridoxal phosphate)lysine 1 PIRSR000463-1 Domain

PIRSF000463 Eukaryota Bacteria

SRHMM000463-1 D Nucleophile E Proton donor 1 PIRSR000485-1 Domain

PIRSF000485 Archaea Eukaryota Bacteria

SRHMM000485-1 C For GATase activity 1 PIRSR000485-3 Domain

PIRSF000485 Archaea Eukaryota Bacteria

SRHMM000485-3 Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster per subunit. C Iron-sulfur (4Fe-4S) C Iron-sulfur (4Fe-4S) C Iron-sulfur (4Fe-4S) C Iron-sulfur (4Fe-4S) 1 PIRSR000495-1 Domain

PIRSF000495 Archaea Eukaryota Bacteria

SRHMM000495-1 C Nucleophile H E 1 PIRSR000498-1 Domain

PIRSF000498 Bacteria

SRHMM000498-1 G-x-[VI] Substrate binding C-x-T Substrate binding [DE]-x(4)-[TSA] Substrate binding 1 PIRSR000509-1 Domain

PIRSF000509 Eukaryota

SRHMM000509-1 [IV]-[LVM] L-tryptophan binding E L-tryptophan R Substrate K Substrate Y Substrate Y L-tryptophan R L-tryptophan R Substrate K Substrate Y Substrate Q Substrate Y Substrate Y Substrate Y Substrate 1 PIRSR000517-1 Domain

PIRSF000517 Eukaryota

SRHMM000517-1 pyridoxal 5'-phosphate K N6-(pyridoxal phosphate)lysine 1 PIRSR000550-1 Domain

PIRSF000550 Eukaryota

SRHMM000550-1 D Proton acceptor 1 PIRSR000550-3 Domain

PIRSF000550 Eukaryota

SRHMM000550-3 ATP-binding [LI]-x(2)-G-x(2)-G-x-V ATP SRHMM000550-3 ATP-binding K ATP 1 PIRSR000552-1 Domain

PIRSF000552 Eukaryota

SRHMM000552-1 D Proton acceptor 1 PIRSR000552-2 Domain

PIRSF000552 Eukaryota

SRHMM000552-2 ATP-binding Nucleotide-binding K ATP SRHMM000552-2 ATP-binding Nucleotide-binding L-G-x-G-x(2)-G-x-V ATP 1 PIRSR000554-1 Domain

PIRSF000554 Eukaryota

SRHMM000554-1 D Proton acceptor 1 PIRSR000554-2 Domain

PIRSF000554 Eukaryota

SRHMM000554-2 ATP-binding Nucleotide-binding K ATP SRHMM000554-2 ATP-binding Nucleotide-binding I-G-x-G-x(4)-V ATP 1 PIRSR000556-1 Domain

PIRSF000556 Eukaryota

SRHMM000556-1 D Proton acceptor 1 PIRSR000556-2 Domain

PIRSF000556 Eukaryota

SRHMM000556-2 ATP-binding Nucleotide-binding K ATP SRHMM000556-2 ATP-binding Nucleotide-binding I-G-x-G-x(2)-G-x-V ATP 1 PIRSR000559-1 Domain

PIRSF000559 Eukaryota

SRHMM000559-1 D Proton acceptor 1 PIRSR000559-2 Domain

PIRSF000559 Eukaryota

SRHMM000559-2 ATP-binding Nucleotide-binding K ATP SRHMM000559-2 ATP-binding Nucleotide-binding L-G-x-G-x(2)-G-x-V ATP 1 PIRSR000604-1 Domain

PIRSF000604 Eukaryota

SRHMM000604-1 D Proton acceptor 1 PIRSR000604-2 Domain

PIRSF000604 Eukaryota

SRHMM000604-2 ATP-binding Nucleotide-binding K ATP SRHMM000604-2 ATP-binding Nucleotide-binding L-G-x(6)-V ATP 1 PIRSR000615-1 Domain

PIRSF000615 Eukaryota Viruses

SRHMM000615-1 D Proton acceptor 1 PIRSR000617-1 Domain

PIRSF000617 Eukaryota

SRHMM000617-1 D Proton acceptor 1 PIRSR000617-2 Domain

PIRSF000617 Eukaryota

SRHMM000617-2 ATP-binding Nucleotide-binding I-x(7)-V ATP SRHMM000617-2 ATP-binding Nucleotide-binding K ATP 1 PIRSR000617-4 Domain

PIRSF000617 Eukaryota Viruses

SRHMM000617-4 Y Phosphotyrosine; by autocatalysis Y Phosphotyrosine; by autocatalysis Y Phosphotyrosine; by autocatalysis Y Phosphotyrosine; by autocatalysis 1 PIRSR000624-1 Domain

PIRSF000624 Eukaryota

SRHMM000624-1 D Proton acceptor 1 PIRSR000624-2 Domain

PIRSF000624 Eukaryota

SRHMM000624-2 ATP-binding Nucleotide-binding K ATP SRHMM000624-2 ATP-binding Nucleotide-binding L-G-x(4)-G-x-[VI] ATP 1 PIRSR000628-1 Domain

PIRSF000628 Eukaryota

SRHMM000628-1 D Proton acceptor 1 PIRSR000632-1 Domain

PIRSF000632 Eukaryota

SRHMM000632-1 D Proton acceptor 1 PIRSR000636-1 Domain

PIRSF000636 Eukaryota

SRHMM000636-1 D Proton acceptor 1 PIRSR000636-2 Domain

PIRSF000636 Eukaryota

SRHMM000636-2 ATP-binding Nucleotide-binding [LI]-x(2)-G-x(2)-G-x-V ATP SRHMM000636-2 ATP-binding Nucleotide-binding K ATP 1 PIRSR000660-1 Domain

PIRSF000660 Eukaryota

SRHMM000660-1 D Proton acceptor 1 PIRSR000660-2 Domain

PIRSF000660 Eukaryota

SRHMM000660-2 ATP-binding Nucleotide-binding K ATP SRHMM000660-2 ATP-binding Nucleotide-binding [LIM]-G-x-G-x(2)-G-x-V ATP 1 PIRSR000666-1 Domain

PIRSF000666 Eukaryota

SRHMM000666-1 D Proton acceptor 1 PIRSR000666-2 Domain

PIRSF000666 Eukaryota

SRHMM000666-2 ATP-binding Nucleotide-binding [IVL]-G-x-G-x(2)-G-x-[VLI] ATP SRHMM000666-2 ATP-binding Nucleotide-binding K ATP 1 PIRSR000699-1 Domain

PIRSF000699 Bacteria

SRHMM000699-1 H Tele-phosphohistidine intermediate; by HPr 1 PIRSR000705-1 Domain

PIRSF000705 Viruses Eukaryota Bacteria

SRHMM000705-1 [ED] Proton acceptor 1 PIRSR000705-2 Domain

PIRSF000705 Viruses Eukaryota Bacteria

SRHMM000705-2 E Substrate Y Substrate Q Substrate R Substrate D Substrate E Substrate 1 PIRSR000706-1 Domain

PIRSF000706 Bacteria

SRHMM000706-1 D Proton acceptor 1 PIRSR000724-1 Domain

PIRSF000724 Archaea Eukaryota Bacteria

SRHMM000724-1 D-x-N Substrate binding R Substrate H-x(2)-[RK] Substrate binding R Substrate R Substrate 1 PIRSR000724-2 Domain

PIRSF000724 Archaea Eukaryota Bacteria

SRHMM000724-2 ATP-binding G-x-D-[TS] ATP SRHMM000724-2 ATP-binding K ATP SRHMM000724-2 ATP-binding G ATP; via carbonyl oxygen SRHMM000724-2 ATP-binding E ATP 1 PIRSR000732-1 Domain

PIRSF000732 Bacteria

SRHMM000732-1 H Tele-phosphohistidine intermediate C Proton donor 1 PIRSR000732-2 Domain

PIRSF000732 Bacteria

SRHMM000732-2 R Substrate R Substrate E Substrate G Substrate; via carbonyl oxygen T Substrate; via amide nitrogen N Substrate D Substrate; via amide nitrogen 1 PIRSR000732-3 Domain

PIRSF000732 Bacteria

SRHMM000732-3 Magnesium Metal-binding Mg(2+) D Magnesium SRHMM000732-3 Magnesium Metal-binding Mg(2+) E Magnesium 1 PIRSR000808-1 Domain

PIRSF000808 Archaea Eukaryota Bacteria

SRHMM000808-1 H Tele-UMP-histidine intermediate 1 PIRSR000808-3 Domain

PIRSF000808 Archaea Eukaryota Bacteria

SRHMM000808-3 Zinc Metal-binding Zn(2+) Binds 1 zinc ion per subunit. C Zinc C Zinc H Zinc H Zinc 1 PIRSR000808-4 Domain

PIRSF000808 Archaea Eukaryota Bacteria

SRHMM000808-4 Iron Metal-binding Fe cation Binds 1 Fe cation per subunit. E Iron H Iron H Iron H Iron 1 PIRSR000817-1 Domain

PIRSF000817 Eukaryota

SRHMM000817-1 Magnesium Metal-binding Mg(2+) D Magnesium SRHMM000817-1 Magnesium Metal-binding Mg(2+) D Magnesium SRHMM000817-1 Magnesium Metal-binding Mg(2+) D Magnesium 1 PIRSR000853-1 Domain

PIRSF000853 Eukaryota Bacteria

SRHMM000853-1 H Tele-phosphohistidine intermediate C Proton donor 1 PIRSR000853-2 Domain

PIRSF000853 Eukaryota Bacteria

SRHMM000853-2 R Substrate R Substrate E Substrate G Substrate; via carbonyl oxygen T Substrate; via amide nitrogen N Substrate D Substrate; via amide nitrogen 1 PIRSR000853-3 Domain

PIRSF000853 Eukaryota Bacteria Archaea

SRHMM000853-3 Magnesium Metal-binding Mg(2+) D Magnesium SRHMM000853-3 Magnesium Metal-binding Mg(2+) E Magnesium 1 PIRSR000858-1 Domain

PIRSF000858 Eukaryota Bacteria

SRHMM000858-1 E 5-glutamyl coenzyme A thioester intermediate 1 PIRSR000865-1 Domain

PIRSF000865 Eukaryota

SRHMM000865-1 S Nucleophile D Charge relay system H Charge relay system 1 PIRSR000865-3 Domain

PIRSF000865 Eukaryota

SRHMM000865-3 Disulfide bond C-x(5)-C C-x(10)-C C-x(23)-C C-x(10)-C C-x(4)-C C-x(15)-C 1 PIRSR000882-1 Domain

PIRSF000882 Eukaryota

SRHMM000882-1 H Proton donor 1 PIRSR000894-1 Domain

PIRSF000894 Eukaryota

SRHMM000894-1 H Nucleophile D Proton donor 1 PIRSR000926-1 Domain

PIRSF000926 Eukaryota

SRHMM000926-1 C Phosphocysteine intermediate 1 PIRSR000926-2 Domain

PIRSF000926 Eukaryota

SRHMM000926-2 D Substrate C-x(5)-R Substrate binding Q Substrate 1 PIRSR000927-1 Domain

PIRSF000927 Eukaryota

SRHMM000927-1 C Phosphocysteine intermediate 1 PIRSR000927-2 Domain

PIRSF000927 Eukaryota

SRHMM000927-2 D Substrate C-x(5)-R Substrate binding Q Substrate 1 PIRSR000929-1 Domain

PIRSF000929 Eukaryota

SRHMM000929-1 C Phosphocysteine intermediate 1 PIRSR000933-50 Domain This rule was created based on analysis for RESID:AA0034.

PIRSF000933 Eukaryota

SRHMM000933-50 C Phosphocysteine intermediate 1 PIRSR000933-51 Domain This rule was created based on analysis for RESID:AA0034.

PIRSF000933 Eukaryota

SRHMM000933-51 D Substrate C-x(5)-R Substrate binding Q Substrate 1 PIRSR000934-1 Domain

PIRSF000934 Eukaryota

SRHMM000934-1 C Phosphocysteine intermediate 1 PIRSR000939-1 Domain

PIRSF000939 Eukaryota

SRHMM000939-1 C Phosphocysteine intermediate 1 PIRSR000956-1 Domain

PIRSF000956 Eukaryota

SRHMM000956-1 H H 1 PIRSR000970-1 Domain

PIRSF000970 Eukaryota

SRHMM000970-1 H Proton acceptor H Proton donor 1 PIRSR000970-2 Domain

PIRSF000970 Eukaryota

SRHMM000970-2 T Substrate T Substrate 1 PIRSR000972-50 Domain This rule was created based on analysis for RESID:AA0185.

PIRSF000972 Chlamydomonadales Fungi

SRHMM000972-50 The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. C 3-oxoalanine (Cys) 1 PIRSR000988-1 Domain

PIRSF000988 Eukaryota

SRHMM000988-1 E H 1 PIRSR000988-2 Domain

PIRSF000988 Eukaryota

SRHMM000988-2 Disulfide bond C-x(35)-C Essential for enzymatic activity SRHMM000988-2 Disulfide bond C-x(2)-C 1 PIRSR000988-3 Domain

PIRSF000988 Archaea Eukaryota Bacteria

SRHMM000988-3 Disulfide bond C-x(35)-C Essential for enzymatic activity 1 PIRSR001000-1 Domain

PIRSF001000 Viruses Bacteria

SRHMM001000-1 E Proton acceptor 1 PIRSR001013-1 Domain

PIRSF001013 Archaea Bacteria

SRHMM001013-1 E Proton acceptor 1 PIRSR001021-1 Domain

PIRSF001021 Bacteria

SRHMM001021-1 D Nucleophile E Proton donor 1 PIRSR001028-1 Domain

PIRSF001028 Viridiplantae

SRHMM001028-1 D Nucleophile E Proton donor 1 PIRSR001028-2 Domain

PIRSF001028 Viridiplantae

SRHMM001028-2 H-x-V Substrate binding Y-[ML] Substrate binding R-x(4)-[RK] Substrate binding W Substrate [NS] Substrate Q Substrate [DE] Substrate K Substrate G-x-[WYL] Substrate binding H Substrate Q Substrate K Substrate [YI]-x-V Substrate binding T-x(5)-D Substrate binding W Substrate 1 PIRSR001031-1 Domain

PIRSF001031 Eukaryota

SRHMM001031-1 D Proton acceptor E Proton donor 1 PIRSR001031-2 Domain

PIRSF001031 Eukaryota

SRHMM001031-2 W Substrate 1 PIRSR001065-1 Domain

PIRSF001065 Eukaryota

SRHMM001065-1 E D 1 PIRSR001084-1 Domain

PIRSF001084 Bacteria

SRHMM001084-1 E Nucleophile SRHMM001084-1 E Proton donor 1 PIRSR001084-2 Domain

PIRSF001084 Bacteria

SRHMM001084-2 R Substrate SRHMM001084-2 N Substrate SRHMM001084-2 W Substrate 1 PIRSR001084-3 Domain

PIRSF001084 Bacteria

SRHMM001084-3 Metal-binding Zinc C Zinc SRHMM001084-3 Metal-binding Zinc C Zinc SRHMM001084-3 Metal-binding Zinc C Zinc SRHMM001084-3 Metal-binding Zinc C Zinc 1 PIRSR001093-1 Domain

PIRSF001093 Eukaryota

SRHMM001093-1 E Proton donor 1 PIRSR001093-2 Domain

PIRSF001093 Eukaryota

SRHMM001093-2 Disulfide bond C-x(45)-C C-x(50)-C C-x(16)-C 1 PIRSR001100-1 Domain

PIRSF001100 Eukaryota Bacteria

SRHMM001100-1 D D Proton donor D Nucleophile 1 PIRSR001109-1 Domain

PIRSF001109 Archaea Eukaryota Bacteria

SRHMM001109-1 T Substrate D Substrate E Substrate K Substrate D Substrate 1 PIRSR001111-50 Domain This rule was created based on analysis for RESID:AA0150.

PIRSF001111 Bacteria Archaea

SRHMM001111-50 Phosphopantetheine Phosphoprotein pantetheine 4'-phosphate Binds 1 phosphopantetheine covalently. S O-(pantetheine 4'-phosphoryl)serine 1 PIRSR001123-1 Domain

PIRSF001123 Bacteria Archaea

SRHMM001123-1 E Proton acceptor 1 PIRSR001134-1 Domain

PIRSF001134 Eukaryota Bacteria

SRHMM001134-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001134-2 Domain

PIRSF001134 Eukaryota Bacteria

SRHMM001134-2 Disulfide bond C-x(9)-C SRHMM001134-2 Disulfide bond C-x(32)-C SRHMM001134-2 Disulfide bond C-x(19)-C 1 PIRSR001141-1 Domain

PIRSF001141 Eukaryota

SRHMM001141-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001143-1 Domain

PIRSF001143 Eukaryota

SRHMM001143-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001154-1 Domain

PIRSF001154 Eukaryota

SRHMM001154-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001155-1 Domain

PIRSF001155 Eukaryota

SRHMM001155-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR001155-2 Domain

PIRSF001155 Eukaryota

SRHMM001155-2 Disulfide bond C-x(18)-C SRHMM001155-2 Disulfide bond C-x(29)-C SRHMM001155-2 Disulfide bond C-x(18)-C SRHMM001155-2 Disulfide bond C-x(125)-C Interchain (between heavy and light chains) SRHMM001155-2 Disulfide bond C-x(40)-C SRHMM001155-2 Disulfide bond C-x(17)-C SRHMM001155-2 Disulfide bond C-x(48)-C SRHMM001155-2 Disulfide bond C-x(17)-C SRHMM001155-2 Disulfide bond C-x(32)-C SRHMM001155-2 Disulfide bond C-x(26)-C SRHMM001155-2 Disulfide bond C-x(12)-C SRHMM001155-2 Disulfide bond C-x(52)-C SRHMM001155-2 Disulfide bond C-x(12)-C 1 PIRSR001174-1 Domain

PIRSF001174 Eukaryota Bacteria Archaea

SRHMM001174-1 S K 1 PIRSR001174-2 Domain

PIRSF001174 Eukaryota Bacteria Archaea

SRHMM001174-2 ATP-binding Nucleotide-binding G-x(6)-[TS] ATP 1 PIRSR001191-1 Domain

PIRSF001191 Viruses Eukaryota

SRHMM001191-1 E 1 PIRSR001196-1 Domain

PIRSF001196 Eukaryota

SRHMM001196-1 E 1 PIRSR001199-1 Domain

PIRSF001199 Eukaryota

SRHMM001199-1 E 1 PIRSR001199-2 Domain

PIRSF001199 Eukaryota

SRHMM001199-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. H Zinc; catalytic SRHMM001199-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. H Zinc; catalytic SRHMM001199-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. H Zinc; catalytic 1 PIRSR001217-1 Domain

PIRSF001217 Eukaryota Bacteria

SRHMM001217-1 K Proton acceptor S Nucleophile 1 PIRSR001220-1 Domain

PIRSF001220 Eukaryota Bacteria

SRHMM001220-1 T O-isoaspartyl threonine intermediate 1 PIRSR001220-2 Domain

PIRSF001220 Eukaryota Bacteria

SRHMM001220-2 S Substrate T-D Substrate binding 1 PIRSR001222-50 Domain This rule was created based on analysis for RESID:AA0114.

PIRSF001222 Eukaryota

SRHMM001222-50 Carbamylation allows a single lysine to coordinate two nickel ions. K N6-carboxylysine 1 PIRSR001222-51 Domain This rule was created based on analysis for RESID:AA0114.

PIRSF001222 Eukaryota

SRHMM001222-51 Metal-binding Nickel Ni cation Binds 2 nickel ions per subunit. H Nickel 1; via tele nitrogen H Nickel 1; via tele nitrogen K Nickel 1; via carbamate group K Nickel 2; via carbamate group H Nickel 2; via pros nitrogen H Nickel 2; via tele nitrogen D Nickel 1 1 PIRSR001238-1 Domain

PIRSF001238 Bacteria

SRHMM001238-1 D Proton acceptor 1 PIRSR001238-2 Domain

PIRSF001238 Bacteria

SRHMM001238-2 G-x-E Substrate binding T Substrate Y Substrate R Substrate R Substrate S Substrate; via amide nitrogen and carbonyl oxygen 1 PIRSR001238-3 Domain

PIRSF001238 Bacteria

SRHMM001238-3 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. D Zinc 1; catalytic SRHMM001238-3 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. H Zinc 1; via tele nitrogen; catalytic SRHMM001238-3 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. H Zinc 1; via tele nitrogen; catalytic SRHMM001238-3 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. K Zinc 1; via carbamate group; catalytic K Zinc 2; via carbamate group; catalytic SRHMM001238-3 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. H Zinc 2; via pros nitrogen; catalytic SRHMM001238-3 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. H Zinc 2; via tele nitrogen; catalytic 1 PIRSR001238-50 Domain This rule was created based on analysis for RESID:AA0114.

PIRSF001238 Bacteria

SRHMM001238-50 Carbamylation allows a single lysine to coordinate two zinc ions. K N6-carboxylysine 1 PIRSR001338-1 Domain

PIRSF001338 Archaea Bacteria

SRHMM001338-1 S Substrate D Substrate [RK] Substrate 1 PIRSR001341-1 Domain

PIRSF001341 Bacteria

SRHMM001341-1 E Proton donor 1 PIRSR001355-1 Domain

PIRSF001355 Bacteria Eukaryota

SRHMM001355-1 S Schiff-base intermediate with substrate; via pyruvic acid C Proton donor; for catalytic activity S Proton acceptor; for processing activity H Proton acceptor; for processing activity 1 PIRSR001355-3 Domain

PIRSF001355 Eukaryota

SRHMM001355-3 S Pyruvic acid (Ser); by autocatalysis 1 PIRSR001359-1 Domain

PIRSF001359 Ascomycota Bacteria

SRHMM001359-1 D Proton donor 1 PIRSR001359-2 Domain

PIRSF001359 Ascomycota Bacteria

SRHMM001359-2 G Dihydroxyacetone phosphate; via amide nitrogen G-x-[ST] Dihydroxyacetone phosphate binding N-x(2)-T Dihydroxyacetone phosphate binding 1 PIRSR001363-1 Domain

PIRSF001363 Eukaryota Bacteria

SRHMM001363-1 R Proton acceptor D Proton donor 1 PIRSR001369-1 Domain

PIRSF001369 Archaea Eukaryota Bacteria

SRHMM001369-1 H [DE] 1 PIRSR001373-1 Domain

PIRSF001373 Bacteria

SRHMM001373-1 [ST] Tryptophan Y Substrate R Substrate G Substrate; via amide nitrogen 1 PIRSR001373-2 Domain

PIRSF001373 Bacteria

SRHMM001373-2 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. E Magnesium SRHMM001373-2 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. E Magnesium 1 PIRSR001399-1 Domain

PIRSF001399 Dikarya Bacteria

SRHMM001399-1 Y Proton acceptor H Proton donor 1 PIRSR001399-2 Domain

PIRSF001399 Dikarya Bacteria

SRHMM001399-2 N Substrate H Substrate D Substrate [ILMV]-[ST] Substrate binding R Substrate 1 PIRSR001399-3 Domain

PIRSF001399 Dikarya Bacteria

SRHMM001399-3 R Transition state stabilizer 1 PIRSR001400-1 Domain

PIRSF001400 Archaea Eukaryota Bacteria

SRHMM001400-1 [ED] Proton donor K Proton acceptor 1 PIRSR001400-2 Domain

PIRSF001400 Archaea Eukaryota Bacteria

SRHMM001400-2 H Substrate E Substrate E Substrate D Substrate S-x(2)-S Substrate binding K Substrate 1 PIRSR001415-1 Domain

PIRSF001415 Archaea Eukaryota Bacteria

SRHMM001415-1 K Schiff-base intermediate with substrate K Schiff-base intermediate with substrate 1 PIRSR001415-2 Domain

PIRSF001415 Archaea Eukaryota Bacteria

SRHMM001415-2 R Substrate 1 R Substrate 1 S Substrate 2 Y Substrate 2 1 PIRSR001415-3 Domain

PIRSF001415 Archaea Fungi Ascomycota Amoebozoa Viridiplantae Bacteria

SRHMM001415-3 Metal-binding Zinc Homooctamer. C Zinc; catalytic C Zinc; catalytic C Zinc; catalytic 1 PIRSR001415-4 Domain

PIRSF001415 Archaea Metazoa Bacteria

SRHMM001415-4 C Zinc 1; catalytic C Zinc 1; catalytic H Zinc 2 C Zinc 1; catalytic C Zinc 2 1 PIRSR001415-5 Domain

PIRSF001415 Archaea Fungi Ascomycota Amoebozoa Viridiplantae Bacteria

SRHMM001415-5 Metal-binding Magnesium E Magnesium 1 PIRSR001430-1 Domain

PIRSF001430 Archaea Eukaryota Bacteria

SRHMM001430-1 D Nucleophile 1 PIRSR001430-2 Domain

PIRSF001430 Archaea Eukaryota Bacteria

SRHMM001430-2 Y Substrate 1 PIRSR001430-3 Domain

PIRSF001430 Archaea Eukaryota Bacteria

SRHMM001430-3 R Interaction with tRNA; Important for base-flipping R Interaction with tRNA R Interaction with tRNA R Interaction with tRNA F Interaction with tRNA Q-x(3)-R Interaction with tRNA 1 PIRSR001434-2 Domain

PIRSF001434 Eukaryota Bacteria

SRHMM001434-2 Pyridoxal phosphate K N6-(pyridoxal phosphate)lysine 1 PIRSR001461-1 Domain

PIRSF001461 Archaea Eukaryota Bacteria

SRHMM001461-1 D Proton donor SRHMM001461-1 D Proton acceptor 1 PIRSR001461-2 Domain

PIRSF001461 Archaea Eukaryota Bacteria

SRHMM001461-2 Cobalt Manganese Metal-binding Zinc a divalent metal cation Binds 1 divalent metal cation per subunit. H Divalent metal cation SRHMM001461-2 Cobalt Manganese Metal-binding Zinc a divalent metal cation Binds 1 divalent metal cation per subunit. D Divalent metal cation SRHMM001461-2 Cobalt Manganese Metal-binding Zinc a divalent metal cation Binds 1 divalent metal cation per subunit. H Divalent metal cation SRHMM001461-2 Cobalt Manganese Metal-binding Zinc a divalent metal cation Binds 1 divalent metal cation per subunit. D Divalent metal cation 1 PIRSR001461-3 Domain

PIRSF001461 Archaea Eukaryota Bacteria

SRHMM001461-3 G-x(2)-[GN] Substrate binding SRHMM001461-3 H Substrate SRHMM001461-3 G Substrate; via amide nitrogen SRHMM001461-3 [GA]-[ST] Substrate binding SRHMM001461-3 S Substrate 1 PIRSR001480-1 Domain

PIRSF001480 Eukaryota Bacteria

SRHMM001480-1 R 1 PIRSR001480-2 Domain

PIRSF001480 Eukaryota Bacteria

SRHMM001480-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. H Zinc SRHMM001480-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. E Zinc SRHMM001480-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. H Zinc SRHMM001480-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. Q Zinc 1 PIRSR001488-1 Domain

PIRSF001488 Proteobacteria

SRHMM001488-1 C-x(2)-C Redox-active 1 PIRSR001522-1 Domain

PIRSF001522 Bacteria

SRHMM001522-1 D D D H 1 PIRSR001553-1 Domain

PIRSF001553 Archaea Eukaryota Bacteria

SRHMM001553-1 H Tele-phosphohistidine intermediate 1 PIRSR001558-1 Domain

PIRSF001558 Eukaryota

SRHMM001558-1 ATP-binding Nucleotide-binding K ATP SRHMM001558-1 ATP-binding Nucleotide-binding [DE] ATP; via carbonyl oxygen SRHMM001558-1 ATP-binding Nucleotide-binding E ATP SRHMM001558-1 ATP-binding Nucleotide-binding Y ATP SRHMM001558-1 ATP-binding Nucleotide-binding M-x(2)-I ATP SRHMM001558-1 ATP-binding Nucleotide-binding K-x(8)-N ATP SRHMM001558-1 ATP-binding Nucleotide-binding K ATP SRHMM001558-1 R Substrate Q Substrate R Substrate SRHMM001558-1 ATP-binding Nucleotide-binding E ATP 1 PIRSR001558-2 Domain

PIRSF001558 Eukaryota

SRHMM001558-2 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. N Magnesium SRHMM001558-2 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. E Magnesium SRHMM001558-2 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. E Magnesium 1 PIRSR001569-1 Domain

PIRSF001569 Eukaryota

SRHMM001569-1 C Glycyl thioester intermediate 1 PIRSR001594-1 Domain

PIRSF001594 Eukaryota Bacteria

SRHMM001594-1 R 1 PIRSR001594-2 Domain

PIRSF001594 Eukaryota Bacteria

SRHMM001594-2 ATP-binding Nucleotide-binding H ATP SRHMM001594-2 R Substrate T Substrate SRHMM001594-2 ATP-binding Nucleotide-binding K ATP SRHMM001594-2 ATP-binding Nucleotide-binding E ATP 1 PIRSR001594-3 Domain

PIRSF001594 Eukaryota Bacteria

SRHMM001594-3 Metal-binding D Divalent metal cation SRHMM001594-3 Metal-binding H Divalent metal cation SRHMM001594-3 Metal-binding K Divalent metal cation; via carbamate group SRHMM001594-3 Metal-binding H Divalent metal cation 1 PIRSR001617-50 Domain This rule was created based on analysis for RESID:AA0150.

PIRSF001617 Fungi

SRHMM001617-50 Phosphopantetheine pantetheine 4'-phosphate Binds 1 phosphopantetheine covalently. S O-(pantetheine 4'-phosphoryl)serine 1 PIRSR001619-1 Domain

PIRSF001619 Archaea Eukaryota Bacteria

SRHMM001619-1 4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. C Iron-sulfur 1 (4Fe-4S-S-AdoMet) SRHMM001619-1 2Fe-2S Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. [RK] Iron-sulfur 2 (2Fe-2S) SRHMM001619-1 2Fe-2S Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. [CS] Iron-sulfur 2 (2Fe-2S) SRHMM001619-1 4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. C Iron-sulfur 1 (4Fe-4S-S-AdoMet) SRHMM001619-1 2Fe-2S Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. [CS] Iron-sulfur 2 (2Fe-2S) SRHMM001619-1 2Fe-2S Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. C Iron-sulfur 2 (2Fe-2S) SRHMM001619-1 4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. C Iron-sulfur 1 (4Fe-4S-S-AdoMet) 1 PIRSR001814-1 Domain

PIRSF001814 Eukaryota

SRHMM001814-1 Disulfide bond C-x(10)-C 1 PIRSR001837-1 Domain

PIRSF001837 Eukaryota

SRHMM001837-1 Disulfide bond C-x(49)-C 1 PIRSR001924-1 Domain

PIRSF001924 Bacteria

SRHMM001924-1 E 1 PIRSR001924-3 Domain

PIRSF001924 Bacteria

SRHMM001924-3 Disulfide bond C-x(18)-C 1 PIRSR001935-1 Domain

PIRSF001935 Eukaryota

SRHMM001935-1 Disulfide bond C-x(5)-C SRHMM001935-1 Disulfide bond C-x(9)-C 1 PIRSR001939-1 Domain

PIRSF001939 Eukaryota

SRHMM001939-1 Disulfide bond C-x(62)-C 1 PIRSR001942-1 Domain

PIRSF001942 Eukaryota

SRHMM001942-1 Disulfide bond C-x(138)-C SRHMM001942-1 Disulfide bond C-x(94)-C SRHMM001942-1 Disulfide bond C-x(44)-C 1 PIRSR001951-1 Domain

PIRSF001951 Eukaryota

SRHMM001951-1 Disulfide bond C-x(3)-C SRHMM001951-1 Disulfide bond C-x(153)-C 1 PIRSR001959-1 Domain

PIRSF001959 Eukaryota

SRHMM001959-1 F Required for ligand binding Y Interaction with APS and STAT5, and activation Y Required for STAT5/PTPN11/SOCS3 binding Y Interaction with PTPN6 Y Required for STAT1/STAT3 activation [YF] Required for CrkL binding 1 PIRSR001959-2 Domain

PIRSF001959 Eukaryota

SRHMM001959-2 Disulfide bond C-x(15)-C SRHMM001959-2 Disulfide bond C-x(9)-C 1 PIRSR001979-1 Domain

PIRSF001979 Eukaryota

SRHMM001979-1 Disulfide bond C-x(51)-C SRHMM001979-1 Disulfide bond C-x(47)-C 1 PIRSR001992-1 Domain

PIRSF001992 Eukaryota

SRHMM001992-1 Disulfide bond C-x(6)-C SRHMM001992-1 Disulfide bond C-x(18)-C SRHMM001992-1 Disulfide bond C-x(18)-C 1 PIRSR002006-1 Domain

PIRSF002006 Eukaryota

SRHMM002006-1 C Phosphocysteine intermediate C Phosphocysteine intermediate 1 PIRSR002006-2 Domain

PIRSF002006 Eukaryota

SRHMM002006-2 D Substrate C-x(5)-R Substrate binding Q Substrate 1 PIRSR002006-3 Domain

PIRSF002006 Eukaryota

SRHMM002006-3 Phosphoprotein Y Phosphotyrosine 1 PIRSR002017-1 Domain

PIRSF002017 Eukaryota

SRHMM002017-1 Disulfide bond C-x(16)-C SRHMM002017-1 Disulfide bond C-x(10)-C SRHMM002017-1 Disulfide bond C-x(29)-C SRHMM002017-1 Disulfide bond C-x(30)-C 1 PIRSR002026-1 Domain

PIRSF002026 Eukaryota

SRHMM002026-1 Iron Metal-binding H Iron (heme proximal ligand) 1 PIRSR002030-1 Domain

PIRSF002030 Eukaryota Bacteria

SRHMM002030-1 Heme Iron Metal-binding heme Binds 1 heme group per subunit. H Iron (heme proximal ligand) 1 PIRSR002356-1 Domain

PIRSF002356 Eukaryota

SRHMM002356-1 Y Carbohydrate K Carbohydrate Y Carbohydrate D Carbohydrate [DE] Carbohydrate 1 PIRSR002412-1 Domain

PIRSF002412 Eukaryota

SRHMM002412-1 I-x(8)-F Acyl-CoA binding Y-x(3)-K Acyl-CoA binding K Acyl-CoA Y Acyl-CoA 1 PIRSR002421-1 Domain

PIRSF002421 Eukaryota

SRHMM002421-1 Disulfide bond C-x(43)-C SRHMM002421-1 Disulfide bond C-x(43)-C SRHMM002421-1 Disulfide bond C-x(18)-C SRHMM002421-1 Disulfide bond C-x(8)-C SRHMM002421-1 Disulfide bond C-x(26)-C SRHMM002421-1 Disulfide bond C-x(10)-C SRHMM002421-1 Disulfide bond C-x(97)-C SRHMM002421-1 Disulfide bond C-x(14)-C SRHMM002421-1 Disulfide bond C-x(26)-C 1 PIRSR002431-1 Domain

PIRSF002431 Eukaryota

SRHMM002431-1 Disulfide bond C-x(74)-C SRHMM002431-1 Disulfide bond C-x(63)-C SRHMM002431-1 Disulfide bond C-x(72)-C SRHMM002431-1 Disulfide bond C-x(10)-C SRHMM002431-1 Disulfide bond C-x(72)-C SRHMM002431-1 Disulfide bond C-x(65)-C SRHMM002431-1 Disulfide bond C-x(10)-C SRHMM002431-1 Disulfide bond C-x(63)-C SRHMM002431-1 Disulfide bond C-x(11)-C SRHMM002431-1 Disulfide bond C-x(10)-C SRHMM002431-1 Disulfide bond C-x(63)-C SRHMM002431-1 Disulfide bond C-x(72)-C 1 PIRSR002486-1 Domain

PIRSF002486 Viruses

SRHMM002486-1 Disulfide bond C-x(26)-C SRHMM002486-1 Disulfide bond C-x(30)-C SRHMM002486-1 Disulfide bond C-x(48)-C SRHMM002486-1 Disulfide bond C-x(39)-C SRHMM002486-1 Disulfide bond C-x(26)-C SRHMM002486-1 Disulfide bond C-x(41)-C SRHMM002486-1 Disulfide bond C-x(41)-C SRHMM002486-1 Disulfide bond C-x(24)-C 1 PIRSR002490-1 Domain

PIRSF002490 Eukaryota

SRHMM002490-1 Disulfide bond C-x(32)-C SRHMM002490-1 Disulfide bond C-x(8)-C SRHMM002490-1 Disulfide bond C-x(5)-C 1 PIRSR002498-2 Domain

PIRSF002498 Eukaryota

SRHMM002498-2 Disulfide bond C S-palmitoyl cysteine 1 PIRSR002572-1 Domain

PIRSF002572 Eukaryota

SRHMM002572-1 Disulfide bond C-x(33)-C SRHMM002572-1 Disulfide bond C-x(25)-C 1 PIRSR002572-2 Domain

PIRSF002572 Eukaryota

SRHMM002572-2 Q Pyrrolidone carboxylic acid 1 PIRSR002799-1 Domain

PIRSF002799 Proteobacteria

SRHMM002799-1 E Proton donor; for transglycosylase activity S Acyl-ester intermediate; for transpeptidase activity 1 PIRSR002811-1 Domain

PIRSF002811 Bacteria

SRHMM002811-1 Metal-binding Zinc Zinc-finger Zn(2+) Binds 1 zinc ion per monomer. C-x(2)-H-x(17)-C-x(2)-C CHC2-type 1 PIRSR002825-1 Domain

PIRSF002825 Bacteria

SRHMM002825-1 Iron Metal-binding Y Iron SRHMM002825-1 Iron Metal-binding H Iron SRHMM002825-1 Iron Metal-binding E Iron SRHMM002825-1 Iron Metal-binding Y Iron 1 PIRSR002855-1 Domain

PIRSF002855 Bacteria

SRHMM002855-1 Peptidoglycan-anchor K N6-murein peptidoglycan lysine 1 PIRSR002855-2 Domain

PIRSF002855 Bacteria

SRHMM002855-2 Palmitate Lipoprotein C N-palmitoyl cysteine C S-diacylglycerol cysteine 1 PIRSR002884-1 Domain

PIRSF002884 Bacteria

SRHMM002884-1 Q Enhances dephosphorylation of CheY-P 1 PIRSR002900-1 Domain

PIRSF002900 Bacteria

SRHMM002900-1 Magnesium Metal-binding H Magnesium (bacteriochlorophyll axial ligand) SRHMM002900-1 Magnesium Metal-binding H Magnesium (bacteriochlorophyll axial ligand) 1 PIRSR002937-1 Domain

PIRSF002937 Bacteria

SRHMM002937-1 Calcium Metal-binding Ca(2+) Binds 1 Ca(2+) ion per subunit. D Calcium SRHMM002937-1 Calcium Metal-binding Ca(2+) Binds 1 Ca(2+) ion per subunit. D Calcium SRHMM002937-1 Calcium Metal-binding Ca(2+) Binds 1 Ca(2+) ion per subunit. D Calcium 1 PIRSR003047-1 Domain

PIRSF003047 Eukaryota

SRHMM003047-1 Disulfide bond C-x(254)-C 1 PIRSR003048-1 Domain

PIRSF003048 Eukaryota

SRHMM003048-1 E Proton donor/acceptor 1 PIRSR003048-2 Domain

PIRSF003048 Eukaryota

SRHMM003048-2 C-x-V Acetyl-CoA binding Q-x(5)-T Acetyl-CoA binding Y-x(2)-G Acetyl-CoA binding 1 PIRSR003085-1 Domain

PIRSF003085 Bacteria

SRHMM003085-1 C 1 PIRSR003085-2 Domain

PIRSF003085 Bacteria

SRHMM003085-2 Y-[ST] S-adenosyl-L-methionine binding [LVI]-x(7)-G S-adenosyl-L-methionine binding T-x(4)-Q S-adenosyl-L-methionine binding [WY]-E S-adenosyl-L-methionine binding 1 PIRSR003092-1 Domain

PIRSF003092 Archaea Eukaryota Bacteria

SRHMM003092-1 ATP-binding Nucleotide-binding G-x(6)-[TS] ATP 1 PIRSR003170-1 Domain

PIRSF003170 Eukaryota Bacteria

SRHMM003170-1 E Proton donor 1 PIRSR003170-2 Domain

PIRSF003170 Eukaryota Bacteria

SRHMM003170-2 D Substrate E Substrate E Substrate 1 PIRSR003182-50 Domain This rule was created based on analysis for RESID:AA0033.

PIRSF003182 Bacteria

SRHMM003182-50 Phosphoprotein Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain. H Phosphohistidine; by autocatalysis D 4-aspartylphosphate H Phosphohistidine 1 PIRSR003726-1 Domain

PIRSF003726 Viruses

SRHMM003726-1 K For methyltransferase activity 1 PIRSR003726-2 Domain

PIRSF003726 Viruses

SRHMM003726-2 Q S-adenosyl-L-methionine Y S-adenosyl-L-methionine G S-adenosyl-L-methionine; via carbonyl oxygen G S-adenosyl-L-methionine; via amide nitrogen D S-adenosyl-L-methionine [RK] S-adenosyl-L-methionine [VA] S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen D S-adenosyl-L-methionine 1 PIRSR004030-1 Domain

PIRSF004030 Viruses

SRHMM004030-1 Myristate G N-myristoyl glycine; by host 1 PIRSR004131-1 Domain

PIRSF004131 Viruses

SRHMM004131-1 Magnesium Metal-binding Y Magnesium SRHMM004131-1 Magnesium Metal-binding D Magnesium SRHMM004131-1 Magnesium Metal-binding G Magnesium; via carbonyl oxygen 1 PIRSR004532-1 Domain

PIRSF004532 Bacteria

SRHMM004532-1 Manganese Metal-binding Mn(2+) D Manganese 1 E Manganese 1 D Manganese 2 [ED] Manganese 2 E Manganese 2 1 PIRSR004532-2 Domain

PIRSF004532 Bacteria

SRHMM004532-2 [ED]-x-T Substrate binding Y Substrate [KR]-x-R Substrate binding D-x-D Substrate binding G Substrate; via amide nitrogen 1 PIRSR004576-50 Domain This rule was created based on analysis for RESID:AA0323.

PIRSF004576 Bacteria

SRHMM004576-50 Y O-(3'-phospho-DNA)-tyrosine intermediate 1 PIRSR004692-1 Domain

PIRSF004692 Bacteria

SRHMM004692-1 H Substrate H Substrate T Substrate D Substrate 1 PIRSR004762-1 Domain

PIRSF004762 Archaea Bacteria

SRHMM004762-1 4Fe-4S Iron Iron-sulfur S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM004762-1 4Fe-4S Iron Iron-sulfur S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM004762-1 4Fe-4S Iron Iron-sulfur S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. C Iron-sulfur (4Fe-4S-S-AdoMet) 1 PIRSR004776-1 Domain

PIRSF004776 Bacteria

SRHMM004776-1 Nucleotide-binding [ST]-x-E NAD 1 SRHMM004776-1 Nucleotide-binding E-x(12)-W NAD 1 SRHMM004776-1 Nucleotide-binding S-x-W NAD 2 SRHMM004776-1 Nucleotide-binding R NAD 1 SRHMM004776-1 Nucleotide-binding H NAD 1 SRHMM004776-1 Nucleotide-binding F-x(2)-F NAD 1 SRHMM004776-1 Nucleotide-binding [FM]-x-[VI] NAD 1 SRHMM004776-1 Nucleotide-binding Y-x(2)-Y NAD 2 1 PIRSR004803-2 Domain

PIRSF004803 Bacteria

SRHMM004803-2 H-x(3)-H Substrate binding 1 PIRSR004848-1 Domain

PIRSF004848 Eukaryota Bacteria

SRHMM004848-1 Pyridoxal phosphate pyridoxal 5'-phosphate K N6-(pyridoxal phosphate)lysine 1 PIRSR004869-50 Domain This rule was created based on analysis for RESID:AA0356.

PIRSF004869 Eukaryota Bacteria Archaea

SRHMM004869-50 Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine [4Fe-4S] cluster Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. C Iron-sulfur (4Fe-4S-S-AdoMet) C Iron-sulfur (4Fe-4S-S-AdoMet) C Iron-sulfur (4Fe-4S-S-AdoMet) 1 PIRSR004911-1 Domain

PIRSF004911 Bacteria Archaea

SRHMM004911-1 4Fe-4S Iron-sulfur Metal-binding C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM004911-1 4Fe-4S Iron-sulfur Metal-binding C Iron-sulfur (4Fe-4S-S-AdoMet) SRHMM004911-1 4Fe-4S Iron-sulfur Metal-binding C Iron-sulfur (4Fe-4S-S-AdoMet) 1 PIRSR005091-1 Domain

PIRSF005091 Bacteria

SRHMM005091-1 [TS] 1 PIRSR005091-2 Domain

PIRSF005091 Bacteria

SRHMM005091-2 Manganese Metal-binding H Substrate 1 PIRSR005091-3 Domain

PIRSF005091 Bacteria

SRHMM005091-3 Manganese Metal-binding H Manganese SRHMM005091-3 Manganese Metal-binding D Manganese SRHMM005091-3 Manganese Metal-binding E Manganese SRHMM005091-3 Manganese Metal-binding T Manganese 1 PIRSR005096-1 Domain

PIRSF005096 Eukaryota Bacteria

SRHMM005096-1 H Proton donor E Proton acceptor 1 PIRSR005096-2 Domain

PIRSF005096 Eukaryota Bacteria

SRHMM005096-2 D Substrate 1 PIRSR005378-1 Domain

PIRSF005378 Eukaryota

SRHMM005378-1 H Tele-AMP-histidine intermediate 1 PIRSR005378-2 Domain

PIRSF005378 Eukaryota

SRHMM005378-2 ATP-binding Nucleotide-binding [YHF]-x(2)-D-Q ATP SRHMM005378-2 ATP-binding Nucleotide-binding Q ATP 1 PIRSR005461-1 Domain

PIRSF005461 Archaea Eukaryota Bacteria

SRHMM005461-1 S-adenosyl-L-methionine K Proton acceptor 1 PIRSR005539-1 Domain

PIRSF005539 Archaea Bacteria

SRHMM005539-1 S Nucleophile [DE] H Proton donor 1 PIRSR005562-1 Domain

PIRSF005562 Eukaryota

SRHMM005562-1 S For acetyltransferase activity S For malonyltransferase activity 1 PIRSR005700-1 Domain

PIRSF005700 Eukaryota Bacteria

SRHMM005700-1 C H N 1 PIRSR005739-1 Domain

PIRSF005739 Eukaryota Bacteria

SRHMM005739-1 H Proton acceptor 1 PIRSR005784-1 Domain

PIRSF005784 Bacteria

SRHMM005784-1 Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. C Iron-sulfur 2 (4Fe-4S) SRHMM005784-1 Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. C Iron-sulfur 2 (4Fe-4S) SRHMM005784-1 Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. C Iron-sulfur 3 (4Fe-4S) SRHMM005784-1 Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster. C Iron-sulfur 1 (2Fe-2S) SRHMM005784-1 Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster. C Iron-sulfur 1 (2Fe-2S) SRHMM005784-1 Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. C Iron-sulfur 2 (4Fe-4S) SRHMM005784-1 Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster. C Iron-sulfur 1 (2Fe-2S) SRHMM005784-1 Iron Iron-sulfur Metal-binding [2Fe-2S] cluster Binds 1 [2Fe-2S] cluster. C Iron-sulfur 1 (2Fe-2S) SRHMM005784-1 Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. C Iron-sulfur 3 (4Fe-4S) SRHMM005784-1 Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. C Iron-sulfur 2 (4Fe-4S) SRHMM005784-1 Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. C Iron-sulfur 3 (4Fe-4S) SRHMM005784-1 Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. C Iron-sulfur 3 (4Fe-4S) 1 PIRSR006019-1 Domain

PIRSF006019 Viruses Eukaryota Bacteria

SRHMM006019-1 E Proton donor 1 PIRSR006019-2 Domain

PIRSF006019 Viruses Eukaryota Bacteria

SRHMM006019-2 Metal-binding Zinc Zn(2+) C Zinc; catalytic SRHMM006019-2 Metal-binding Zinc Zn(2+) C Zinc; catalytic SRHMM006019-2 Metal-binding Zinc Zn(2+) H Zinc; catalytic 1 PIRSR006105-1 Domain

PIRSF006105 Bacteria

SRHMM006105-1 Heme Binds 2 heme C groups per subunit. C Heme C 1 (covalent) SRHMM006105-1 Heme Binds 2 heme C groups per subunit. C Heme C 2 (covalent) SRHMM006105-1 Heme Binds 2 heme C groups per subunit. C Heme C 2 (covalent) SRHMM006105-1 Heme Binds 2 heme C groups per subunit. C Heme C 1 (covalent) 1 PIRSR006105-2 Domain

PIRSF006105 Bacteria

SRHMM006105-2 Iron Metal-binding H Iron (heme C 2 axial ligand); via tele nitrogen SRHMM006105-2 Iron Metal-binding H Iron (heme C 1 axial ligand); via tele nitrogen SRHMM006105-2 Iron Metal-binding H Iron (heme C 1 axial ligand); via tele nitrogen SRHMM006105-2 Iron Metal-binding H Iron (heme C 2 axial ligand); via tele nitrogen 1 PIRSR006135-1 Domain

PIRSF006135 Bacteria

SRHMM006135-1 H GMP-histidine intermediate 1 PIRSR006135-2 Domain

PIRSF006135 Bacteria

SRHMM006135-2 GTP-binding Nucleotide-binding Homotrimer. A-x-[SGA] GTP SRHMM006135-2 GTP-binding Nucleotide-binding Homotrimer. [KR]-x(2)-R GTP SRHMM006135-2 GTP-binding Nucleotide-binding Homotrimer. E GTP SRHMM006135-2 GTP-binding Nucleotide-binding Homotrimer. G-x(6)-S GTP SRHMM006135-2 GTP-binding Nucleotide-binding Homotrimer. [ED] GTP; via carbonyl oxygen 1 PIRSR006230-1 Domain

PIRSF006230 Eukaryota Bacteria

SRHMM006230-1 GTP-binding Nucleotide-binding G GTP; via amide nitrogen SRHMM006230-1 GTP-binding Nucleotide-binding N-S GTP SRHMM006230-1 GTP-binding Nucleotide-binding N-x(2)-D GTP SRHMM006230-1 GTP-binding Nucleotide-binding N-x(3)-S-[TS] GTP 1 PIRSR006246-1 Domain

PIRSF006246 Bacteria

SRHMM006246-1 Y Proton donor SRHMM006246-1 Schiff base Pyruvate pyruvoyl group S Schiff-base intermediate with substrate; via pyruvic acid 1 PIRSR006246-2 Domain

PIRSF006246 Bacteria

SRHMM006246-2 T Substrate G-[AGSP]-[AT] Substrate binding 1 PIRSR006246-3 Domain

PIRSF006246 Bacteria

SRHMM006246-3 Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. S Pyruvic acid (Ser) 1 PIRSR006246-5 Domain

PIRSF006246 Bacteria

SRHMM006246-5 M-x(22)-G S-x(100)-A 1 PIRSR006250-1 Domain

PIRSF006250 Archaea Eukaryota Bacteria

SRHMM006250-1 [RK] Substrate T-x-[KR] Substrate binding R Substrate K Substrate E Substrate D Substrate S-x-[GNS] Substrate binding [VMLIS]-x-[AFTM] Substrate binding 1 PIRSR006325-1 Domain

PIRSF006325 Bacteria

SRHMM006325-1 S-adenosyl-L-methionine G-x-S S-adenosyl-L-methionine binding SRHMM006325-1 S-adenosyl-L-methionine N S-adenosyl-L-methionine SRHMM006325-1 S-adenosyl-L-methionine D-[ILV] S-adenosyl-L-methionine binding SRHMM006325-1 S-adenosyl-L-methionine D S-adenosyl-L-methionine SRHMM006325-1 S-adenosyl-L-methionine Y S-adenosyl-L-methionine 1 PIRSR006334-1 Domain

PIRSF006334 Eukaryota Bacteria

SRHMM006334-1 E Proton donor 1 PIRSR006334-2 Domain

PIRSF006334 Eukaryota Bacteria

SRHMM006334-2 N-x-E Substrate binding 1 PIRSR006334-3 Domain

PIRSF006334 Eukaryota Bacteria

SRHMM006334-3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion. H Zinc; catalytic C Zinc; catalytic C Zinc; catalytic 1 PIRSR006337-1 Domain

PIRSF006337 Archaea Bacteria

SRHMM006337-1 Cytoplasm D Nucleophile E Proton donor 1 PIRSR006337-2 Domain

PIRSF006337 Archaea Bacteria

SRHMM006337-2 D-x(3)-H Substrate binding E Substrate 1 PIRSR006337-3 Domain

PIRSF006337 Archaea Bacteria

SRHMM006337-3 D Transition state stabilizer 1 PIRSR006356-1 Domain

PIRSF006356 Bacteria

SRHMM006356-1 C Amidino-cysteine intermediate 1 PIRSR006431-1 Domain

PIRSF006431 Eukaryota Bacteria

SRHMM006431-1 S Nucleophile D H Proton donor 1 PIRSR006439-50 Domain This rule was created based on analysis for RESID:AA0140.

PIRSF006439 Bacteria Archaea

SRHMM006439-50 4Fe-4S Iron Iron-sulfur Metal-binding [4Fe-4S] cluster Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP. C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) 1 PIRSR006468-1 Domain

PIRSF006468 Eukaryota Bacteria

SRHMM006468-1 K N6-(pyridoxal phosphate)lysine 1 PIRSR006614-1 Domain

PIRSF006614 Bacteria

SRHMM006614-1 D 1 PIRSR006816-1 Domain

PIRSF006816 Archaea Bacteria

SRHMM006816-1 FAD Flavoprotein FAD Binds 1 FAD per subunit. G-T FAD SRHMM006816-1 FAD Flavoprotein FAD Binds 1 FAD per subunit. [LIV]-x-[RQ] FAD SRHMM006816-1 FAD Flavoprotein FAD Binds 1 FAD per subunit. R-x(2)-S FAD 1 PIRSR009283-1 Domain

PIRSF009283 Eukaryota Bacteria

SRHMM009283-1 Metal-binding Iron Fe cation Binds 1 Fe cation per subunit. Belongs to the 4HPPD family. H Iron H Iron E Iron 1 PIRSR009285-1 Domain

PIRSF009285 Eukaryota

SRHMM009285-1 S-adenosyl-L-methionine W-E S-adenosyl-L-methionine binding SRHMM009285-1 S-adenosyl-L-methionine W S-adenosyl-L-methionine SRHMM009285-1 S-adenosyl-L-methionine E-x-N S-adenosyl-L-methionine binding SRHMM009285-1 S-adenosyl-L-methionine M S-adenosyl-L-methionine SRHMM009285-1 S-adenosyl-L-methionine F-G-M-x-I-A S-adenosyl-L-methionine binding SRHMM009285-1 L-T Substrate binding SRHMM009285-1 E Substrate SRHMM009285-1 M Substrate 1 PIRSR009407-1 Domain

PIRSF009407 Bacteria

SRHMM009407-1 K Critical for catalysis Y Critical for catalysis 1 PIRSR009407-2 Domain

PIRSF009407 Bacteria

SRHMM009407-2 S-x(2)-N-x(3)-R Substrate binding R Substrate R Substrate 1 PIRSR009407-3 Domain

PIRSF009407 Bacteria

SRHMM009407-3 Magnesium Metal-binding Mg(2+) Mn(2+) Binds 1 Mg(2+) or Mn(2+) ion per subunit. D Magnesium or manganese D Magnesium or manganese D Magnesium or manganese 1 PIRSR013503-1 Domain

PIRSF013503 Eukaryota

SRHMM013503-1 D C Nucleophile H 1 PIRSR015582-1 Domain

PIRSF015582 Eukaryota Bacteria

SRHMM015582-1 R Substrate E Substrate 1 PIRSR015582-2 Domain

PIRSF015582 Eukaryota Bacteria

SRHMM015582-2 Magnesium Metal-binding E Magnesium SRHMM015582-2 Magnesium Metal-binding D Magnesium 1 PIRSR015604-1 Domain

PIRSF015604 Eukaryota

SRHMM015604-1 Disulfide bond C-x(19)-C SRHMM015604-1 Disulfide bond C-x(34)-C SRHMM015604-1 Disulfide bond C-x(57)-C 1 PIRSR015853-1 Domain

PIRSF015853 Bacteria

SRHMM015853-1 H Nucleophile 1 PIRSR015853-2 Domain

PIRSF015853 Bacteria

SRHMM015853-2 Metal-binding Zinc H Zinc 2 SRHMM015853-2 Metal-binding Zinc D Zinc 1 D Zinc 2 SRHMM015853-2 Metal-binding Zinc H Zinc 2 SRHMM015853-2 Metal-binding Zinc E Zinc 1 SRHMM015853-2 Metal-binding Zinc E Zinc 2 1 PIRSR015894-1 Domain

PIRSF015894 Eukaryota

SRHMM015894-1 E Proton donor/acceptor E Proton donor/acceptor 1 PIRSR015894-2 Domain

PIRSF015894 Eukaryota

SRHMM015894-2 S-adenosyl-L-methionine D-M S-adenosyl-L-methionine binding SRHMM015894-2 S-adenosyl-L-methionine K-Y S-adenosyl-L-methionine binding SRHMM015894-2 S-adenosyl-L-methionine Y S-adenosyl-L-methionine SRHMM015894-2 S-adenosyl-L-methionine E S-adenosyl-L-methionine 1 PIRSR015894-3 Domain

PIRSF015894 Eukaryota

SRHMM015894-3 F Critical for specifying symmetric addition of methyl groups 1 PIRSR016020-1 Domain

PIRSF016020 Eukaryota Bacteria

SRHMM016020-1 H E 1 PIRSR016020-2 Domain

PIRSF016020 Eukaryota Bacteria

SRHMM016020-2 R Substrate Q Substrate R Substrate 1 PIRSR016184-1 Domain

PIRSF016184 Eukaryota Bacteria

SRHMM016184-1 E 1 PIRSR016262-1 Domain

PIRSF016262 Eukaryota Bacteria Archaea

SRHMM016262-1 C Acyl-thioester intermediate 1 PIRSR016262-2 Domain

PIRSF016262 Eukaryota Bacteria Archaea

SRHMM016262-2 R-x(6)-H Substrate binding [AS]-x-[GA] Substrate binding G-x-[ASG] Substrate binding 1 PIRSR016262-3 Domain

PIRSF016262 Eukaryota Bacteria Archaea

SRHMM016262-3 K Lowers pKa of active site Cys 1 PIRSR016305-1 Domain

PIRSF016305 Eukaryota

SRHMM016305-1 S-adenosyl-L-methionine G S-adenosyl-L-methionine; via carbonyl oxygen SRHMM016305-1 S-adenosyl-L-methionine E S-adenosyl-L-methionine; via carbonyl oxygen SRHMM016305-1 S-adenosyl-L-methionine R S-adenosyl-L-methionine SRHMM016305-1 S-adenosyl-L-methionine [DN]-[LIVF] S-adenosyl-L-methionine binding 1 PIRSR016308-1 Domain

PIRSF016308 Eukaryota

SRHMM016308-1 C Nucleophile H Proton acceptor 1 PIRSR016308-2 Domain

PIRSF016308 Eukaryota

SRHMM016308-2 W Substrate R-x(2)-F Substrate binding Y Substrate Y Substrate; via carbonyl oxygen D Substrate 1 PIRSR016308-4 Domain

PIRSF016308 Eukaryota

SRHMM016308-4 Disulfide bond C-x(620)-C 1 PIRSR016487-1 Domain

PIRSF016487 Bacteria

SRHMM016487-1 Y Proton acceptor 1 PIRSR016496-1 Domain

PIRSF016496 Archaea Eukaryota Bacteria

SRHMM016496-1 ATP-binding Nucleotide-binding K ATP SRHMM016496-1 ATP-binding Nucleotide-binding D ATP SRHMM016496-1 [GAST] Substrate; via amide nitrogen SRHMM016496-1 H Substrate SRHMM016496-1 ATP-binding Nucleotide-binding Y-x(4)-K ATP SRHMM016496-1 ATP-binding Nucleotide-binding [GAST] ATP; via carbonyl oxygen SRHMM016496-1 [GAST] Substrate; via amide nitrogen SRHMM016496-1 ATP-binding Nucleotide-binding K-x(3)-S ATP SRHMM016496-1 ATP-binding Nucleotide-binding [GAST] ATP; via amide nitrogen 1 PIRSR016496-2 Domain

PIRSF016496 Archaea Eukaryota Bacteria

SRHMM016496-2 K Transition state stabilizer 1 PIRSR016573-1 Domain

PIRSF016573 Bacteria

SRHMM016573-1 E 1 PIRSR016573-2 Domain

PIRSF016573 Bacteria

SRHMM016573-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. H Zinc; catalytic SRHMM016573-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. D Zinc; catalytic SRHMM016573-2 Calcium Metal-binding Ca(2+) Binds 1 Ca(2+) ion per subunit. T Calcium SRHMM016573-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. H Zinc; catalytic SRHMM016573-2 Calcium Metal-binding Ca(2+) Binds 1 Ca(2+) ion per subunit. D Calcium 1 PIRSR016573-3 Domain

PIRSF016573 Bacteria

SRHMM016573-3 C-x(12)-C 1 PIRSR016616-1 Domain

PIRSF016616 Bacteria Eukaryota

SRHMM016616-1 S-adenosyl-L-methionine G S-adenosyl-L-methionine; via carbonyl oxygen E S-adenosyl-L-methionine Q S-adenosyl-L-methionine S S-adenosyl-L-methionine; via amide nitrogen I S-adenosyl-L-methionine; via carbonyl oxygen 1 PIRSR016616-2 Domain

PIRSF016616 Bacteria Eukaryota

SRHMM016616-2 E Substrate N Substrate 1 PIRSR017269-1 Domain

PIRSF017269 Eukaryota Bacteria Archaea

SRHMM017269-1 S-adenosyl-L-methionine H S-adenosyl-L-methionine SRHMM017269-1 S-adenosyl-L-methionine D S-adenosyl-L-methionine SRHMM017269-1 S-adenosyl-L-methionine S-x(2)-L S-adenosyl-L-methionine binding SRHMM017269-1 S-adenosyl-L-methionine D S-adenosyl-L-methionine SRHMM017269-1 S-adenosyl-L-methionine [ED] S-adenosyl-L-methionine 1 PIRSR017434-1 Domain

PIRSF017434 Eukaryota Bacteria

SRHMM017434-1 D Nucleophile D Proton donor 1 PIRSR017434-2 Domain

PIRSF017434 Eukaryota Bacteria

SRHMM017434-2 Metal-binding Magnesium Mg(2+) Binds 1 Mg(2+) ion per subunit. D Magnesium D Magnesium; via carbonyl oxygen D Magnesium 1 PIRSR017570-1 Domain

PIRSF017570 Fungi

SRHMM017570-1 S-adenosyl-L-methionine E S-adenosyl-L-methionine SRHMM017570-1 S-adenosyl-L-methionine [SD]-F S-adenosyl-L-methionine binding SRHMM017570-1 S-adenosyl-L-methionine Y-x(2)-L S-adenosyl-L-methionine binding SRHMM017570-1 S-adenosyl-L-methionine F-x-D-x-G-x(4)-N S-adenosyl-L-methionine binding 1 PIRSR017689-50 Domain This rule was created based on analysis for RESID:AA0119.

PIRSF017689 Eukaryota Archaea

SRHMM017689-50 K tRNA acceptor arm SRHMM017689-50 R Substrate SRHMM017689-50 R tRNA variable arm SRHMM017689-50 Q Substrate SRHMM017689-50 Pyridoxal phosphate RNA-binding tRNA-binding pyridoxal 5'-phosphate E May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate R Pyridoxal phosphate S Substrate R Substrate K N6-(pyridoxal phosphate)lysine SRHMM017689-50 R tRNA discriminator base 1 PIRSR017818-1 Domain

PIRSF017818 Bacteria

SRHMM017818-1 D Nucleophile D Proton donor 1 PIRSR017818-2 Domain

PIRSF017818 Bacteria

SRHMM017818-2 T-G Substrate binding K Substrate 1 PIRSR017818-3 Domain

PIRSF017818 Bacteria

SRHMM017818-3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. D Magnesium; via carbonyl oxygen SRHMM017818-3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. D Magnesium SRHMM017818-3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. D Magnesium 1 PIRSR018001-2 Domain

PIRSF018001 Eukaryota Bacteria

SRHMM018001-2 R Substrate N-R Substrate binding Y-x(3)-R Substrate binding E Substrate Y Substrate 1 PIRSR018001-3 Domain

PIRSF018001 Eukaryota Bacteria

SRHMM018001-3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. H Zinc SRHMM018001-3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. E Zinc SRHMM018001-3 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. H Zinc 1 PIRSR018169-1 Domain

PIRSF018169 Eukaryota

SRHMM018169-1 S Nucleophile D Charge relay system H Charge relay system 1 PIRSR018249-1 Domain

PIRSF018249 Bacteria

SRHMM018249-1 Metal-binding Zinc C Zinc SRHMM018249-1 Metal-binding Zinc H Zinc SRHMM018249-1 Metal-binding Zinc C Zinc SRHMM018249-1 Metal-binding Zinc C Zinc 1 PIRSR018249-2 Domain

PIRSF018249 Bacteria

SRHMM018249-2 S-adenosyl-L-methionine [YF] S-adenosyl-L-methionine SRHMM018249-2 S-adenosyl-L-methionine [ET]-G S-adenosyl-L-methionine binding SRHMM018249-2 S-adenosyl-L-methionine [HY] S-adenosyl-L-methionine 1 PIRSR018250-1 Domain

PIRSF018250 Bacteria Eukaryota

SRHMM018250-1 C 1 PIRSR018427-1 Domain

PIRSF018427 Eukaryota Bacteria

SRHMM018427-1 C E 1 PIRSR023956-1 Domain

PIRSF023956 Eukaryota Bacteria

SRHMM023956-1 S-adenosyl-L-methionine W-x(3)-W-x(6)-F S-adenosyl-L-methionine binding L S-adenosyl-L-methionine; via carbonyl oxygen E S-adenosyl-L-methionine S-I S-adenosyl-L-methionine binding R S-adenosyl-L-methionine 1 PIRSR028757-1 Domain

PIRSF028757 Bacteria

SRHMM028757-1 S Nucleophile E Charge relay system H Charge relay system 1 PIRSR028762-1 Domain

PIRSF028762 Eukaryota

SRHMM028762-1 S-adenosyl-L-methionine K S-adenosyl-L-methionine SRHMM028762-1 S-adenosyl-L-methionine [QM]-x-[CAVST] S-adenosyl-L-methionine binding SRHMM028762-1 S-adenosyl-L-methionine D-[CS] S-adenosyl-L-methionine binding SRHMM028762-1 S-adenosyl-L-methionine [GAC] S-adenosyl-L-methionine; via carbonyl oxygen SRHMM028762-1 S-adenosyl-L-methionine D S-adenosyl-L-methionine 1 PIRSR028973-1 Domain

PIRSF028973 Eukaryota

SRHMM028973-1 H Nucleophile 1 PIRSR029256-1 Domain

PIRSF029256 Bacteria

SRHMM029256-1 S-adenosyl-L-methionine [ILMV] S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen SRHMM029256-1 S-adenosyl-L-methionine S S-adenosyl-L-methionine SRHMM029256-1 S-adenosyl-L-methionine [LIMV] S-adenosyl-L-methionine; via carbonyl oxygen SRHMM029256-1 S-adenosyl-L-methionine G S-adenosyl-L-methionine; via amide nitrogen 1 PIRSR029681-1 Domain

PIRSF029681 Bacteria

SRHMM029681-1 H Charge relay system S Charge relay system [ED] Charge relay system 1 PIRSR029681-2 Domain

PIRSF029681 Bacteria

SRHMM029681-2 N Critical for activity 1 PIRSR036298-50 Domain This rule was created based on analysis for RESID:AA0140.

PIRSF036298 Archaea Bacteria

SRHMM036298-50 4Fe-4S Metal-binding Iron-sulfur Iron [4Fe-4S] cluster Binds 4 [4Fe-4S] clusters per subunit. C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 4 (4Fe-4S) C Iron-sulfur 4 (4Fe-4S) C Iron-sulfur 4 (4Fe-4S) C Iron-sulfur 4 (4Fe-4S) C Iron-sulfur 3 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 2 (4Fe-4S) C Iron-sulfur 1 (4Fe-4S) 1 PIRSR036417-1 Domain

PIRSF036417 Magnoliophyta

SRHMM036417-1 C H H H H N 1 PIRSR036421-1 Domain

PIRSF036421 Archaea Bacteria

SRHMM036421-1 H Charge relay system S Nucleophile E Charge relay system 1 PIRSR036432-1 Domain

PIRSF036432 Archaea Eukaryota

SRHMM036432-1 S-adenosyl-L-methionine D S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen SRHMM036432-1 S-adenosyl-L-methionine [HQY] S-adenosyl-L-methionine; via carbonyl oxygen SRHMM036432-1 S-adenosyl-L-methionine [VILMGAT] S-adenosyl-L-methionine; via carbonyl oxygen SRHMM036432-1 S-adenosyl-L-methionine [STN]-[IVGA] S-adenosyl-L-methionine binding SRHMM036432-1 S-adenosyl-L-methionine [LIV] S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen SRHMM036432-1 S-adenosyl-L-methionine [LI] S-adenosyl-L-methionine; via carbonyl oxygen SRHMM036432-1 S-adenosyl-L-methionine [ALMV] S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen 1 PIRSR036489-1 Domain

PIRSF036489 Eukaryota

SRHMM036489-1 H Proton donor E Proton acceptor C Proton donor 1 PIRSR036489-2 Domain

PIRSF036489 Eukaryota

SRHMM036489-2 Q-x-I Substrate binding D Substrate 1 PIRSR036489-4 Domain

PIRSF036489 Eukaryota

SRHMM036489-4 D Essential for catalytic activity 1 PIRSR036497-1 Domain

PIRSF036497 Archaea Eukaryota Bacteria

SRHMM036497-1 K Proton donor 1 PIRSR036497-2 Domain

PIRSF036497 Archaea Eukaryota Bacteria

SRHMM036497-2 NADP G-x(4)-G NADP SRHMM036497-2 NADP K NADP SRHMM036497-2 E Substrate SRHMM036497-2 NADP T NADP 1 PIRSR036503-50 Domain This rule was created based on analysis for RESID:AA0036.

PIRSF036503 Eukaryota

SRHMM036503-50 H Pros-phosphohistidine intermediate 1 PIRSR036503-51 Domain This rule was created based on analysis for RESID:AA0036.

PIRSF036503 Eukaryota

SRHMM036503-51 ATP-binding Nucleotide-binding K ATP F ATP R ATP N ATP 1 PIRSR036511-1 Domain

PIRSF036511 Eukaryota

SRHMM036511-1 H Tele-phosphohistidine intermediate 1 PIRSR036636-50 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF036636 Bacteria

SRHMM036636-50 Heme C Heme (covalent) C Heme (covalent) 1 PIRSR036636-51 Domain This rule was created based on analysis for RESID:AA0134.

PIRSF036636 Bacteria

SRHMM036636-51 Heme Iron Metal-binding H Iron (heme axial ligand) 1 PIRSR036665-50 Domain This rule was created based on analysis for RESID:AA0185.

PIRSF036665 Chordata

SRHMM036665-50 The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. C 3-oxoalanine (Cys) 1 PIRSR036666-50 Domain This rule was created based on analysis for RESID:AA0185.

PIRSF036666 Bacteria Eukaryota

SRHMM036666-50 The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. C 3-oxoalanine (Cys) 1 PIRSR036696-1 Domain

PIRSF036696 Eukaryota

SRHMM036696-1 E Proton acceptor SRHMM036696-1 D 1 PIRSR036874-51 Domain This rule was created based on analysis for RESID:AA0106.

PIRSF036874 Viruses

SRHMM036874-51 Lipoprotein Palmitate C S-palmitoyl cysteine; by host SRHMM036874-51 Lipoprotein Palmitate C S-palmitoyl cysteine; by host SRHMM036874-51 Lipoprotein Palmitate C S-palmitoyl cysteine; by host 1 PIRSR036936-1 Domain

PIRSF036936 Eukaryota

SRHMM036936-1 C For GATase activity H For GATase activity E For GATase activity D D 1 PIRSR036959-1 Domain

PIRSF036959 Eukaryota

SRHMM036959-1 K N6-GMP-lysine intermediate 1 PIRSR036960-1 Domain

PIRSF036960 Eukaryota

SRHMM036960-1 Calcium Metal-binding D Calcium SRHMM036960-1 Calcium Metal-binding D Calcium SRHMM036960-1 Calcium Metal-binding E Calcium 1 PIRSR036960-2 Domain

PIRSF036960 Eukaryota

SRHMM036960-2 Disulfide bond C-x(21)-C SRHMM036960-2 Disulfide bond C-x(157)-C SRHMM036960-2 Disulfide bond C-x(21)-C SRHMM036960-2 Disulfide bond C-x(26)-C SRHMM036960-2 Disulfide bond C-x(149)-C SRHMM036960-2 Disulfide bond C-x(25)-C 1 PIRSR037215-1 Domain

PIRSF037215 Bacteria

SRHMM037215-1 D E Proton acceptor 1 PIRSR037215-2 Domain

PIRSF037215 Bacteria

SRHMM037215-2 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. D Zinc 2 SRHMM037215-2 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. D Zinc 1 SRHMM037215-2 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. H Zinc 2 SRHMM037215-2 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. H Zinc 1 SRHMM037215-2 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. E Zinc 2 SRHMM037215-2 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. D Zinc 1 1 PIRSR037281-1 Domain

PIRSF037281 Eukaryota

SRHMM037281-1 D Proton acceptor 1 PIRSR037281-2 Domain

PIRSF037281 Eukaryota

SRHMM037281-2 ATP-binding Nucleotide-binding I-x(7)-V ATP SRHMM037281-2 ATP-binding Nucleotide-binding K ATP 1 PIRSR037293-1 Domain

PIRSF037293 Eukaryota

SRHMM037293-1 Disulfide bond C-x(2)-C Redox-active SRHMM037293-1 Disulfide bond C-x(2)-C Redox-active SRHMM037293-1 Disulfide bond C-x(2)-C Redox-active SRHMM037293-1 Disulfide bond C-x(2)-C Redox-active 1 PIRSR037322-1 Domain

PIRSF037322 Eukaryota

SRHMM037322-1 C Phosphocysteine intermediate 1 PIRSR037505-2 Domain

PIRSF037505 Bacteria Eukaryota

SRHMM037505-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. C Zinc SRHMM037505-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. C Zinc SRHMM037505-2 Metal-binding Zinc Zn(2+) Binds 1 zinc ion per subunit. C Zinc 1 PIRSR037575-1 Domain

PIRSF037575 Eukaryota

SRHMM037575-1 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. C Zinc 1 SRHMM037575-1 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. H Zinc 2 SRHMM037575-1 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. H Zinc 1 SRHMM037575-1 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. C Zinc 2 SRHMM037575-1 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. C Zinc 2 SRHMM037575-1 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. C Zinc 1 SRHMM037575-1 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. C Zinc 2 SRHMM037575-1 Metal-binding Zinc Zn(2+) Binds 2 Zn(2+) ions per subunit. C Zinc 1 1 PIRSR037599-2 Domain

PIRSF037599 Bacteria

SRHMM037599-2 F-L Substrate binding F Substrate R Substrate 1 PIRSR037599-3 Domain

PIRSF037599 Bacteria

SRHMM037599-3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. G Magnesium; via carbonyl oxygen SRHMM037599-3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. E Magnesium SRHMM037599-3 Magnesium Metal-binding Mg(2+) Binds 1 Mg(2+) ion per subunit. Q Magnesium 1 PIRSR037599-4 Domain

PIRSF037599 Bacteria

SRHMM037599-4 G-x(5)-E-x(7)-R-x(4)-E-x-G Nudix box 1 PIRSR037736-1 Domain

PIRSF037736 Eukaryota

SRHMM037736-1 Copper Metal-binding C Copper SRHMM037736-1 Copper Metal-binding H Copper SRHMM037736-1 Copper Metal-binding C Copper 1 PIRSR037839-1 Domain

PIRSF037839 Bacteria

SRHMM037839-1 Mn(2+) Mg(2+) Binds 2 metal ions per subunit. Manganese or magnesium. Metal-binding Manganese Magnesium D Magnesium 1 SRHMM037839-1 Mn(2+) Mg(2+) Binds 2 metal ions per subunit. Manganese or magnesium. Metal-binding Manganese Magnesium D Magnesium 1 SRHMM037839-1 Mn(2+) Mg(2+) Binds 2 metal ions per subunit. Manganese or magnesium. Metal-binding Manganese Magnesium E Magnesium 2 SRHMM037839-1 Mn(2+) Mg(2+) Binds 2 metal ions per subunit. Manganese or magnesium. Metal-binding Manganese Magnesium D Magnesium 2 1 PIRSR037847-1 Domain

PIRSF037847 Bacteria

SRHMM037847-1 Metal-binding Nickel H Nickel; via tele nitrogen SRHMM037847-1 Metal-binding Nickel H Nickel; via tele nitrogen SRHMM037847-1 Metal-binding Nickel [ED] Nickel SRHMM037847-1 Metal-binding Nickel H Nickel; via tele nitrogen 1 PIRSR037880-1 Domain

PIRSF037880 Eukaryota

SRHMM037880-1 C 1 PIRSR037911-1 Domain

PIRSF037911 Eukaryota

SRHMM037911-1 H 1 PIRSR037911-2 Domain

PIRSF037911 Eukaryota

SRHMM037911-2 Metal-binding Zinc C Zinc SRHMM037911-2 Metal-binding Zinc C Zinc SRHMM037911-2 Metal-binding Zinc H Zinc SRHMM037911-2 Metal-binding Zinc C Zinc 1 PIRSR037921-1 Domain

PIRSF037921 Eukaryota

SRHMM037921-1 D Proton acceptor 1 PIRSR037921-2 Domain

PIRSF037921 Eukaryota

SRHMM037921-2 ATP-binding Nucleotide-binding K ATP SRHMM037921-2 ATP-binding Nucleotide-binding [LI]-x(7)-V ATP 1 PIRSR037932-1 Domain

PIRSF037932 Eukaryota

SRHMM037932-1 RNA-binding R Interaction with RNA F Interaction with RNA R Interaction with RNA N Interaction with RNA K Interaction with RNA F Interaction with RNA R Interaction with RNA R Interaction with RNA 1 PIRSR037941-1 Domain

PIRSF037941 Eukaryota

SRHMM037941-1 H Charge relay system D Charge relay system S Charge relay system 1 PIRSR037947-1 Domain

PIRSF037947 Eukaryota

SRHMM037947-1 GTP-binding Nucleotide-binding G-S GTP SRHMM037947-1 GTP-binding Nucleotide-binding Q-x(2)-R GTP 1 PIRSR037947-2 Domain

PIRSF037947 Eukaryota

SRHMM037947-2 G N-myristoyl glycine C S-palmitoyl cysteine 1 PIRSR037993-1 Domain

PIRSF037993 Eukaryota

SRHMM037993-1 D Proton acceptor 1 PIRSR038001-1 Domain

PIRSF038001 Eukaryota

SRHMM038001-1 H C 1 PIRSR038023-1 Domain

PIRSF038023 Eukaryota

SRHMM038023-1 Metal-binding T Divalent metal cation SRHMM038023-1 Metal-binding S Divalent metal cation SRHMM038023-1 Metal-binding S Divalent metal cation 1 PIRSR038023-2 Domain

PIRSF038023 Eukaryota

SRHMM038023-2 Disulfide bond C-x(178)-C 1 PIRSR038073-1 Domain

PIRSF038073 Eukaryota

SRHMM038073-1 D 1 PIRSR038073-2 Domain

PIRSF038073 Eukaryota

SRHMM038073-2 R Substrate D Substrate 1 PIRSR038120-1 Domain

PIRSF038120 Eukaryota

SRHMM038120-1 C Nucleophile H Proton donor 1 PIRSR038120-2 Domain

PIRSF038120 Eukaryota

SRHMM038120-2 D Important for enzyme activity 1 PIRSR038134-1 Domain

PIRSF038134 Eukaryota

SRHMM038134-1 Nucleotide-binding E-N GTP SRHMM038134-1 Nucleotide-binding H GTP; via amide nitrogen SRHMM038134-1 Nucleotide-binding G-x(4)-S GTP SRHMM038134-1 Nucleotide-binding S-x(4)-E GTP 1 PIRSR038142-50 Domain This rule was created based on analysis for RESID:AA0120. The UniProtKB entry with the shared homology domain and experimental information is P02699.

PIRSF038142 Bacteria

SRHMM038142-50 Chromophore Retinal protein Contains one covalently linked retinal chromophore. K N6-(retinylidene)lysine 1 PIRSR038172-1 Domain

PIRSF038172 Eukaryota

SRHMM038172-1 D Proton acceptor 1 PIRSR038172-2 Domain

PIRSF038172 Eukaryota

SRHMM038172-2 ATP-binding Nucleotide-binding [LVI]-x(7)-V ATP K ATP 1 PIRSR038186-2 Domain

PIRSF038186 Eukaryota

SRHMM038186-2 Mg(2+) Binds 2 magnesium ions per subunit. Metal-binding Magnesium D magnesium 1 SRHMM038186-2 Mg(2+) Binds 2 magnesium ions per subunit. Metal-binding Magnesium N magnesium 2 SRHMM038186-2 Mg(2+) Binds 2 magnesium ions per subunit. Metal-binding Magnesium D magnesium 1 D magnesium 2 1 PIRSR038189-1 Domain

PIRSF038189 Eukaryota

SRHMM038189-1 D Proton acceptor 1 PIRSR038189-2 Domain

PIRSF038189 Eukaryota

SRHMM038189-2 ATP-binding Nucleotide-binding K ATP SRHMM038189-2 ATP-binding Nucleotide-binding K-x-A ATP SRHMM038189-2 ATP-binding Nucleotide-binding K ATP 1 PIRSR038455-1 Domain

PIRSF038455 Bacteria

SRHMM038455-1 C Cysteine persulfide intermediate 1 PIRSR038455-2 Domain

PIRSF038455 Bacteria

SRHMM038455-2 Heme heme Binds 2 heme groups per subunit. C Heme 2 (covalent) SRHMM038455-2 Heme heme Binds 2 heme groups per subunit. C Heme 1 (covalent) R Substrate SRHMM038455-2 Heme heme Binds 2 heme groups per subunit. C Heme 2 (covalent) SRHMM038455-2 Heme heme Binds 2 heme groups per subunit. C Heme 1 (covalent) 1 PIRSR038927-1 Domain

PIRSF038927 Eukaryota Bacteria

SRHMM038927-1 H N 1 PIRSR038927-2 Domain

PIRSF038927 Eukaryota Bacteria

SRHMM038927-2 Iron Metal-binding heme Y Iron (heme axial ligand) 1 PIRSR038928-1 Domain

PIRSF038928 Archaea Eukaryota Bacteria

SRHMM038928-1 H N 1 PIRSR038928-2 Domain

PIRSF038928 Archaea Eukaryota Bacteria

SRHMM038928-2 Heme Iron Metal-binding heme Y Iron (heme axial ligand) 1 PIRSR038941-1 Domain

PIRSF038941 Bacteria

SRHMM038941-1 D Substrate SRHMM038941-1 E Substrate 1 PIRSR038945-1 Domain

PIRSF038945 Bacteria Archaea

SRHMM038945-1 Pyridoxal phosphate pyridoxal 5'-phosphate G-x(3)-N Pyridoxal phosphate binding SRHMM038945-1 Pyridoxal phosphate pyridoxal 5'-phosphate N Pyridoxal phosphate SRHMM038945-1 Pyridoxal phosphate pyridoxal 5'-phosphate T Pyridoxal phosphate 1 PIRSR038945-2 Domain

PIRSF038945 Bacteria Archaea

SRHMM038945-2 K N6-(pyridoxal phosphate)lysine 1 PIRSR038994-1 Domain

PIRSF038994 Eukaryota Bacteria

SRHMM038994-1 D Proton donor/acceptor 1 PIRSR038994-2 Domain

PIRSF038994 Eukaryota Bacteria

SRHMM038994-2 [TAIVC] Substrate; via amide nitrogen N-[AG] Substrate binding R Substrate H Substrate; via tele nitrogen [LI]-x-G Substrate binding 1 PIRSR039144-50 Domain This rule was created based on analysis for RESID:AA0256.

PIRSF039144 Bacteria

SRHMM039144-50 Y O-UMP-tyrosine 1 PIRSR601559-50 Domain This rule was created based on analysis for RESID:AA0114.

IPR001559 Eukaryota Bacteria Archaea

SRHMM601559-50 K N6-carboxylysine 1 PIRSR601559-51 Domain This rule was created based on analysis for RESID:AA0114.

IPR001559 Eukaryota Bacteria Archaea

SRHMM601559-51 Metal-binding a divalent metal cation Binds 2 divalent metal cations per subunit. H Divalent metal cation 1; via tele nitrogen H Divalent metal cation 1; via tele nitrogen K Divalent metal cation 1; via carbamate group K Divalent metal cation 2; via carbamate group H Divalent metal cation 2; via pros nitrogen H Divalent metal cation 2; via tele nitrogen D Divalent metal cation 1 1 PIRSR602129-50 Domain This rule was created based on analysis for RESID:AA0119.

IPR002129 Eukaryota Bacteria Archaea

SRHMM602129-50 Pyridoxal phosphate pyridoxal 5'-phosphate K N6-(pyridoxal phosphate)lysine 1 PIRSR603437-50 Domain This rule was created based on analysis for RESID:AA0119.

IPR003437 Eukaryota Bacteria

SRHMM603437-50 Pyridoxal phosphate pyridoxal 5'-phosphate K N6-(pyridoxal phosphate)lysine 1 PIRSR603739-50 Domain This rule was created based on analysis for RESID:AA0119.

IPR003739 Bacteria Archaea

SRHMM603739-50 Pyridoxal phosphate pyridoxal 5'-phosphate K N6-(pyridoxal phosphate)lysine 1 PIRSR604550-50 Domain This rule was created based on analysis for RESID:AA0525.

IPR004550 Eukaryota Bacteria

SRHMM604550-50 T Acyl-ester intermediate 1 PIRSR604809-50 Domain This rule was created based on analysis for RESID:AA0203.

IPR004809 Bacteria Archaea

SRHMM604809-50 Phosphoprotein Y O-AMP-tyrosine 1 PIRSR605977-50 Domain

IPR005977 Bacteria Archaea

SRHMM605977-50 ADP-ribosylation The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity. R ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase 1 PIRSR611166-50 Domain This rule was created based on analysis for RESID:AA0119.

IPR011166 Bacteria

SRHMM611166-50 Pyridoxal phosphate pyridoxal 5'-phosphate K N6-(pyridoxal phosphate)lysine