part_of
type: ObjectProperty
type: TransitiveProperty
has db xref: BFO:0000050
has OBO namespace: protein
id: part_of
shorthand: part_of

has_part
type: ObjectProperty
type: TransitiveProperty
has db xref: BFO:0000051
has OBO namespace: protein
id: has_part
shorthand: has_part

has_quality
type: ObjectProperty
has db xref: RO:0000086
has OBO namespace: protein
id: has_quality
is transitive: false
shorthand: has_quality

only_in_taxon
type: ObjectProperty
IAO_0000115: U only_in_taxon T: U is a feature found in only in organisms of species of taxon T. The feature cannot be found in an organism of any species outside of (not subsumed by) that taxon. Down-propagates in U hierarchy, up-propagates in T hierarchy (species taxonomy). Implies applicable_to_taxon.
has db xref: RO:0002160
has exact synonym: never_outside_taxon
has exact synonym: specific_to
has exact synonym: specific_to_taxon
has OBO namespace: protein
id: only_in_taxon
is transitive: false
shorthand: only_in_taxon
comment: Down-propagates. The original name for this in the paper is 'specific_to'. Applicable to genes because some genes are lost in sub-species (strains) of a species.

Axiom
annotated source: only_in_taxon
annotated property: IAO_0000115
annotated target: U only_in_taxon T: U is a feature found in only in organisms of species of taxon T. The feature cannot be found in an organism of any species outside of (not subsumed by) that taxon. Down-propagates in U hierarchy, up-propagates in T hierarchy (species taxonomy). Implies applicable_to_taxon.
has db xref: ROC:Waclaw

has_component
type: ObjectProperty
has db xref: RO:0002180
has OBO namespace: protein
id: has_component
is transitive: false
shorthand: has_component

output_of
type: ObjectProperty
has db xref: RO:0002353
has OBO namespace: protein
id: output_of
is transitive: false
shorthand: output_of

has_gene_template
type: ObjectProperty
has OBO namespace: protein
id: has_gene_template
is transitive: false

lacks_part
type: ObjectProperty
has OBO namespace: protein
id: lacks_part
is transitive: false

process
type: Class
has OBO namespace: bfo
id: BFO:0000015

quality
type: Class
has OBO namespace: bfo
id: BFO:0000019

fiat object part
type: Class
subclass of: material entity
has OBO namespace: bfo
id: BFO:0000024

object
type: Class
subclass of: material entity
has OBO namespace: bfo
id: BFO:0000030

material entity
type: Class
has OBO namespace: bfo
id: BFO:0000040

molecular entity
type: Class
subclass of: chemical entity
IAO_0000115: Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
has OBO namespace: chebi_ontology
id: CHEBI:23367

Axiom
annotated source: molecular entity
annotated property: IAO_0000115
annotated target: Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
has db xref: fake:2

chemical entity
type: Class
subclass of: object
IAO_0000115: A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
has OBO namespace: chebi_ontology
id: CHEBI:24431

L-glutamic acid residue
type: Class
subclass of: proteinogenic amino-acid residue
has OBO namespace: chebi_ontology
id: CHEBI:29972

organic group
type: Class
subclass of: molecular entity
IAO_0000115: Any substituent group or skeleton containing carbon.
has OBO namespace: chebi_ontology
id: CHEBI:33247

proteinogenic amino-acid residue
type: Class
subclass of: amino-acid residue
has OBO namespace: protein
id: CHEBI:33700

amino-acid residue
type: Class
subclass of: organic group
IAO_0000115: When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue.
has exact synonym: amino acid residue
has narrow synonym: protein residue
has OBO namespace: chebi_ontology
id: CHEBI:33708

Axiom
annotated source: amino-acid residue
annotated property: IAO_0000115
annotated target: When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue.
has db xref: Dummy:dummy

Axiom
annotated source: amino-acid residue
annotated property: hasNarrowSynonym
annotated target: protein residue
has db xref: PRO:DAN

L-tyrosine residue
type: Class
subclass of: proteinogenic amino-acid residue
has OBO namespace: chebi_ontology
id: CHEBI:46858

organic amino compound
type: Class
subclass of: molecular entity
IAO_0000115: A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups.
has OBO namespace: chebi_ontology
id: CHEBI:50047

L-proline residue
type: Class
subclass of: proteinogenic amino-acid residue
has OBO namespace: chebi_ontology
id: CHEBI:50342

translation
type: Class
subclass of: biological_process
IAO_0000115: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
has exact synonym: protein anabolism
has OBO namespace: biological_process
id: GO:0006412

Axiom
annotated source: translation
annotated property: IAO_0000115
annotated target: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
has db xref: GOC:go_curators

biological_process
type: Class
subclass of: process
has OBO namespace: biological_process
id: GO:0008150

protein processing
type: Class
subclass of: biological_process
IAO_0000115: Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
has OBO namespace: biological_process
has related synonym: peptidolysis during protein maturation
id: GO:0016485

Axiom
annotated source: protein processing
annotated property: IAO_0000115
annotated target: Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
has db xref: GOC:curators
has db xref: GOC:jl
has db xref: GOC:jsg

Axiom
annotated source: protein processing
annotated property: hasRelatedSynonym
annotated target: peptidolysis during protein maturation
has db xref: GOC:mah

protein-containing complex
type: Class
IAO_0000115: Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.
has exact synonym: protein-protein complex
has OBO namespace: cellular_component
id: GO:0032991
comment: Note that although at some level almost all cellular components can be thought of as protein complexes, this term is intended to exclude structures composed of the same repeating subunit or subunits, for example microtubules. Protein complexes encompassed by this term are generally not structural, and usually have a defined set of subunits.

Axiom
annotated source: protein-containing complex
annotated property: IAO_0000115
annotated target: Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.
has db xref: GOC:go_curators

IgA immunoglobulin complex, circulating
type: Class
subclass of: protein-containing complex
IAO_0000115: A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
has exact synonym: IgA antibody
has OBO namespace: cellular_component
id: GO:0071746
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.

Axiom
annotated source: IgA immunoglobulin complex, circulating
annotated property: hasExactSynonym
annotated target: IgA antibody
has db xref: GOC:add

Axiom
annotated source: IgA immunoglobulin complex, circulating
annotated property: IAO_0000115
annotated target: A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
has db xref: GOC:add
has db xref: ISBN:0781765196
has db xref: PMID:16362985

BGLAP (human)
type: Class
subclass of: protein_coding_gene
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A protein coding gene BGLAP in human.
has OBO namespace: gene
id: HGNC:1043
comment: Category=external.

Axiom
annotated source: BGLAP (human)
annotated property: IAO_0000115
annotated target: A protein coding gene BGLAP in human.
has db xref: PRO:DNx

CD28 (human)
type: Class
subclass of: protein_coding_gene
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A protein coding gene CD28 in human.
has OBO namespace: gene
id: HGNC:1653
comment: Category=external.

Axiom
annotated source: CD28 (human)
annotated property: IAO_0000115
annotated target: A protein coding gene CD28 in human.
has db xref: PRO:DNx

COL5A1 (human)
type: Class
subclass of: protein_coding_gene
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A protein coding gene COL5A1 in human.
has OBO namespace: gene
id: HGNC:2209
comment: Category=external.

Axiom
annotated source: COL5A1 (human)
annotated property: IAO_0000115
annotated target: A protein coding gene COL5A1 in human.
has db xref: PRO:DNx

JCHAIN (human)
type: Class
subclass of: protein_coding_gene
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A protein coding gene JCHAIN in human.
has OBO namespace: gene
id: HGNC:5713
comment: Category=external.

Axiom
annotated source: JCHAIN (human)
annotated property: IAO_0000115
annotated target: A protein coding gene JCHAIN in human.
has db xref: PRO:DNx

PIGR (human)
type: Class
subclass of: protein_coding_gene
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A protein coding gene PIGR in human.
has OBO namespace: gene
id: HGNC:8968
comment: Category=external.

Axiom
annotated source: PIGR (human)
annotated property: IAO_0000115
annotated target: A protein coding gene PIGR in human.
has db xref: PRO:DNx

3-hydroxy-L-proline
type: Class
subclass of: hydroxylated residue
subclass of: modified L-proline residue
has exact synonym: 3HyPro
has OBO namespace: PSI-MOD
id: MOD:00038

Axiom
annotated source: 3-hydroxy-L-proline
annotated property: hasExactSynonym
annotated target: 3HyPro
has synonym type: PSI-MOD-label

4-hydroxy-L-proline
type: Class
subclass of: hydroxylated residue
subclass of: modified L-proline residue
has exact synonym: 4HyPro
has OBO namespace: PSI-MOD
id: MOD:00039

Axiom
annotated source: 4-hydroxy-L-proline
annotated property: hasExactSynonym
annotated target: 4HyPro
has synonym type: PSI-MOD-label

L-gamma-carboxyglutamic acid
type: Class
subclass of: modified L-glutamic acid residue
subclass of: carboxylated residue
has exact synonym: 4CbxGlu
has OBO namespace: PSI-MOD
id: MOD:00041

Axiom
annotated source: L-gamma-carboxyglutamic acid
annotated property: hasExactSynonym
annotated target: 4CbxGlu
has synonym type: PSI-MOD-label

O4'-phospho-L-tyrosine
type: Class
subclass of: phosphorylated residue
subclass of: modified L-tyrosine residue
has exact synonym: OPTyr
has OBO namespace: PSI-MOD
id: MOD:00048

Axiom
annotated source: O4'-phospho-L-tyrosine
annotated property: hasExactSynonym
annotated target: OPTyr
has synonym type: PSI-MOD-label

hydroxylated residue
type: Class
subclass of: modified amino-acid residue
has OBO namespace: PSI-MOD
id: MOD:00677

phosphorylated residue
type: Class
subclass of: modified amino-acid residue
has OBO namespace: PSI-MOD
id: MOD:00696

modified L-glutamic acid residue
type: Class
subclass of: modified amino-acid residue
has OBO namespace: PSI-MOD
id: MOD:00906

modified L-proline residue
type: Class
subclass of: modified amino-acid residue
has OBO namespace: PSI-MOD
id: MOD:00915

modified L-tyrosine residue
type: Class
subclass of: modified amino-acid residue
has OBO namespace: PSI-MOD
id: MOD:00919

carboxylated residue
type: Class
subclass of: modified amino-acid residue
has exact synonym: CbxRes
has OBO namespace: PSI-MOD
id: MOD:01152

Axiom
annotated source: carboxylated residue
annotated property: hasExactSynonym
annotated target: CbxRes
has db xref: PRO:DAN
has synonym type: PSI-MOD-label

Eukaryota
type: Class
subclass of: organism
has OBO namespace: ncbi_taxonomy
has related synonym: euk-
id: NCBITaxon:2759

Axiom
annotated source: Eukaryota
annotated property: hasRelatedSynonym
annotated target: euk-
has db xref: PRO:DAN
has synonym type: PRO-short-label

Opisthokonta
type: Class
subclass of: Eukaryota
has OBO namespace: ncbi_taxonomy
has related synonym: Fungi/Metazoa group
id: NCBITaxon:33154

Metazoa
type: Class
subclass of: Opisthokonta
has OBO namespace: ncbi_taxonomy
has related synonym: metazoan-
id: NCBITaxon:33208

Axiom
annotated source: Metazoa
annotated property: hasRelatedSynonym
annotated target: metazoan-
has db xref: PRO:DAN
has synonym type: PRO-short-label

Mammalia
type: Class
subclass of: Metazoa
has exact synonym: mammal
has OBO namespace: ncbi_taxonomy
has related synonym: mammal-
id: NCBITaxon:40674

Axiom
annotated source: Mammalia
annotated property: hasExactSynonym
annotated target: mammal
has synonym type: PRO-common-name

Axiom
annotated source: Mammalia
annotated property: hasRelatedSynonym
annotated target: mammal-
has db xref: PRO:DAN
has synonym type: PRO-short-label

Homo sapiens
type: Class
subclass of: Mammalia
has OBO namespace: ncbi_taxonomy
has related synonym: h
has related synonym: human
id: NCBITaxon:9606

Axiom
annotated source: Homo sapiens
annotated property: hasRelatedSynonym
annotated target: h
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: Homo sapiens
annotated property: hasRelatedSynonym
annotated target: human
has db xref: PRO:DAN
has synonym type: PRO-common-name

organism
type: Class
subclass of: object
has OBO namespace: obi
id: OBI:0100026

protein
type: Class
subclass of: amino acid chain
subclass of: Restriction
  on property: output_of
  some values from: translation
IAO_0000115: An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
has exact synonym: natural protein
has narrow synonym: native protein
has OBO namespace: protein
id: PR:000000001
comment: The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB].

Axiom
annotated source: protein
annotated property: IAO_0000115
annotated target: An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
has db xref: PRO:DAN
has db xref: PRO:WCB

Axiom
annotated source: protein
annotated property: hasExactSynonym
annotated target: natural protein
has db xref: PRO:DAN

Axiom
annotated source: protein
annotated property: hasNarrowSynonym
annotated target: native protein
has db xref: IEDB:BP

T-cell-specific surface glycoprotein CD28
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human CD28 gene or a 1:1 ortholog thereof.
has archetype: T-cell-specific surface glycoprotein CD28 (human)
has db xref: IUPHARobj:2863
has exact synonym: CD28
has exact synonym: TP44
has OBO namespace: protein
id: PR:000001841
comment: Category=gene. Requested by=CL.

Axiom
annotated source: T-cell-specific surface glycoprotein CD28
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human CD28 gene or a 1:1 ortholog thereof.
has db xref: PRO:WCB

Axiom
annotated source: T-cell-specific surface glycoprotein CD28
annotated property: hasExactSynonym
annotated target: CD28
has db xref: PRO:DNx
has synonym type: PRO-short-label

collagen alpha chain
type: Class
subclass of: protein
IAO_0000115: A protein that is a component of collagen. Collagens are trimeric molecules in which each chain comprises a repeating Gly-X-Y triplet, in which X and Y can be any residue but are usually proline and hydroxyproline, respectively. This results in a left-handed helix that combines with other two to form a triple-helical structure.
has OBO namespace: protein
id: PR:000003262
comment: Category=family.

Axiom
annotated source: collagen alpha chain
annotated property: IAO_0000115
annotated target: A protein that is a component of collagen. Collagens are trimeric molecules in which each chain comprises a repeating Gly-X-Y triplet, in which X and Y can be any residue but are usually proline and hydroxyproline, respectively. This results in a left-handed helix that combines with other two to form a triple-helical structure.
has db xref: PMID:15788652
has db xref: PMID:1639194
has db xref: Pfam:PF01391

collagen alpha-1(V) chain
type: Class
subclass of: collagen type V alpha chain
IAO_0000115: A collagen type V alpha chain that is a translation product of the human COL5A1 gene or a 1:1 ortholog thereof.
has archetype: collagen alpha-1(V) chain (human)
has exact synonym: COL5A1
has OBO namespace: protein
id: PR:000003345
comment: Category=gene.

Axiom
annotated source: collagen alpha-1(V) chain
annotated property: IAO_0000115
annotated target: A collagen type V alpha chain that is a translation product of the human COL5A1 gene or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: collagen alpha-1(V) chain
annotated property: hasExactSynonym
annotated target: COL5A1
has db xref: PRO:DNx
has synonym type: PRO-short-label

collagen type V alpha chain
type: Class
subclass of: collagen alpha chain
IAO_0000115: A collagen alpha chain that is a translation product of the human COL5A1, COL5A2, or COL5A3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has OBO namespace: protein
id: PR:000003387
comment: Category=family.

Axiom
annotated source: collagen type V alpha chain
annotated property: IAO_0000115
annotated target: A collagen alpha chain that is a translation product of the human COL5A1, COL5A2, or COL5A3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
has db xref: PMID:15788652
has db xref: PRO:CNA
has db xref: PRO:DAN

immunoglobulin J chain
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human JCHAIN gene or a 1:1 ortholog thereof.
has archetype: immunoglobulin J chain (human)
has exact synonym: JCHAIN
has OBO namespace: protein
has related synonym: IGCJ
has related synonym: IGJ
id: PR:000008965
comment: Category=gene.

Axiom
annotated source: immunoglobulin J chain
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human JCHAIN gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: immunoglobulin J chain
annotated property: hasExactSynonym
annotated target: JCHAIN
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: immunoglobulin J chain
annotated property: hasRelatedSynonym
annotated target: IGCJ
has synonym type: Gene-based

Axiom
annotated source: immunoglobulin J chain
annotated property: hasRelatedSynonym
annotated target: IGJ
has synonym type: Gene-based

polymeric immunoglobulin receptor
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human PIGR gene or a 1:1 ortholog thereof.
has archetype: polymeric immunoglobulin receptor (human)
has exact synonym: PIGR
has exact synonym: PIgR
has exact synonym: hepatocellular carcinoma-associated protein TB6
has exact synonym: poly-Ig receptor
has OBO namespace: protein
id: PR:000012705
comment: Category=gene.

Axiom
annotated source: polymeric immunoglobulin receptor
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human PIGR gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: polymeric immunoglobulin receptor
annotated property: hasExactSynonym
annotated target: PIGR
has db xref: PRO:DNx
has synonym type: PRO-short-label

amino acid chain
type: Class
subclass of: organic amino compound
subclass of: Restriction
  on property: has_part
  some values from: amino-acid residue
IAO_0000115: An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds.
has narrow synonym: peptide
has narrow synonym: polypeptide
has OBO namespace: protein
id: PR:000018263
comment: Category=external.

Axiom
annotated source: amino acid chain
annotated property: IAO_0000115
annotated target: An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds.
has db xref: PRO:DAN
has db xref: PRO:JSG

Axiom
annotated source: amino acid chain
annotated property: hasNarrowSynonym
annotated target: peptide
has db xref: PRO:DAN

Axiom
annotated source: amino acid chain
annotated property: hasNarrowSynonym
annotated target: polypeptide
has db xref: PRO:DAN

proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: protein
  intersection of: Restriction
    on property: output_of
    some values from: protein processing
IAO_0000115: A protein that is produced as the result of proteolytic processing of a longer protein.
has exact synonym: ClvPrd
has narrow synonym: peptide
has narrow synonym: polypeptide
has OBO namespace: protein
id: PR:000018264

Axiom
annotated source: proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A protein that is produced as the result of proteolytic processing of a longer protein.
has db xref: PRO:DAN

Axiom
annotated source: proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: ClvPrd
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: proteolytic cleavage product
annotated property: hasNarrowSynonym
annotated target: peptide
has db xref: PRO:DAN

Axiom
annotated source: proteolytic cleavage product
annotated property: hasNarrowSynonym
annotated target: polypeptide
has db xref: PRO:DAN

T-cell-specific surface glycoprotein CD28, signal peptide removed form
type: Class
equivalent class: Class
  intersection of: T-cell-specific surface glycoprotein CD28
  intersection of: Restriction
    on property: lacks_part
    some values from: signal_peptide
IAO_0000115: A T-cell-specific surface glycoprotein CD28 that has had the signal peptide removed.
has exact synonym: CD28/SigPep-
has OBO namespace: protein
id: PR:000018541
comment: Category=modification.

Axiom
annotated source: T-cell-specific surface glycoprotein CD28, signal peptide removed form
annotated property: IAO_0000115
annotated target: A T-cell-specific surface glycoprotein CD28 that has had the signal peptide removed.
has db xref: PRO:DNx

Axiom
annotated source: T-cell-specific surface glycoprotein CD28, signal peptide removed form
annotated property: hasExactSynonym
annotated target: CD28/SigPep-
has db xref: PRO:DNx
has synonym type: PRO-short-label

collagen alpha-1(V) chain proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: collagen alpha-1(V) chain
  intersection of: Restriction
    on property: output_of
    some values from: protein processing
IAO_0000115: A collagen alpha-1(V) chain that has been processed by proteolytic cleavage.
has exact synonym: COL5A1/ClvPrd
has OBO namespace: protein
id: PR:000018813
comment: Category=modification.

Axiom
annotated source: collagen alpha-1(V) chain proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A collagen alpha-1(V) chain that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: collagen alpha-1(V) chain proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: COL5A1/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

immunoglobulin J chain, signal peptide removed form
type: Class
equivalent class: Class
  intersection of: immunoglobulin J chain
  intersection of: Restriction
    on property: lacks_part
    some values from: signal_peptide
IAO_0000115: An immunoglobulin J chain that has had the signal peptide removed.
has exact synonym: JCHAIN/SigPep-
has OBO namespace: protein
id: PR:000020282
comment: Category=modification.

Axiom
annotated source: immunoglobulin J chain, signal peptide removed form
annotated property: IAO_0000115
annotated target: An immunoglobulin J chain that has had the signal peptide removed.
has db xref: PRO:DNx

Axiom
annotated source: immunoglobulin J chain, signal peptide removed form
annotated property: hasExactSynonym
annotated target: JCHAIN/SigPep-
has db xref: PRO:DNx
has synonym type: PRO-short-label

polymeric immunoglobulin receptor, signal peptide removed form
type: Class
equivalent class: Class
  intersection of: polymeric immunoglobulin receptor
  intersection of: Restriction
    on property: lacks_part
    some values from: signal_peptide
IAO_0000115: A polymeric immunoglobulin receptor that has had the signal peptide removed.
has exact synonym: PIGR/SigPep-
has OBO namespace: protein
id: PR:000020965
comment: Category=modification.

Axiom
annotated source: polymeric immunoglobulin receptor, signal peptide removed form
annotated property: IAO_0000115
annotated target: A polymeric immunoglobulin receptor that has had the signal peptide removed.
has db xref: PRO:DNx

Axiom
annotated source: polymeric immunoglobulin receptor, signal peptide removed form
annotated property: hasExactSynonym
annotated target: PIGR/SigPep-
has db xref: PRO:DNx
has synonym type: PRO-short-label

polymeric immunoglobulin receptor proteolytic cleavage product
type: Class
equivalent class: Class
  intersection of: polymeric immunoglobulin receptor
  intersection of: Restriction
    on property: output_of
    some values from: protein processing
IAO_0000115: A polymeric immunoglobulin receptor that has been processed by proteolytic cleavage.
has exact synonym: PIGR/ClvPrd
has OBO namespace: protein
id: PR:000020966
comment: Category=modification.

Axiom
annotated source: polymeric immunoglobulin receptor proteolytic cleavage product
annotated property: IAO_0000115
annotated target: A polymeric immunoglobulin receptor that has been processed by proteolytic cleavage.
has db xref: PRO:DNx

Axiom
annotated source: polymeric immunoglobulin receptor proteolytic cleavage product
annotated property: hasExactSynonym
annotated target: PIGR/ClvPrd
has db xref: PRO:DNx
has synonym type: PRO-short-label

immature protein part
type: Class
subclass of: fiat object part
subclass of: Restriction
  on property: part_of
  some values from: protein
IAO_0000115: A part of a protein that is removed during the protein maturation process.
has exact synonym: cleaved_peptide_region
has OBO namespace: protein
id: PR:000021935

Axiom
annotated source: immature protein part
annotated property: IAO_0000115
annotated target: A part of a protein that is removed during the protein maturation process.
has db xref: PRO:DAN

Axiom
annotated source: immature protein part
annotated property: hasExactSynonym
annotated target: cleaved_peptide_region
has db xref: SO:0100011

osteocalcin pre-pro-protein
type: Class
equivalent class: Class
  intersection of: osteocalcin
  intersection of: Restriction
    on property: has_part
    some values from: signal_peptide
  intersection of: Restriction
    on property: has_part
    some values from: propeptide
IAO_0000115: An osteocalcin that has not been proteolytically processed.
has exact synonym: OC-prepro
has OBO namespace: protein
id: PR:000024866
comment: Category=modification.

Axiom
annotated source: osteocalcin pre-pro-protein
annotated property: hasExactSynonym
annotated target: OC-prepro
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: osteocalcin pre-pro-protein
annotated property: IAO_0000115
annotated target: An osteocalcin that has not been proteolytically processed.
has db xref: PRO:DAN

osteocalcin pro-protein
type: Class
equivalent class: Class
  intersection of: osteocalcin
  intersection of: Restriction
    on property: has_part
    some values from: propeptide
  intersection of: Restriction
    on property: lacks_part
    some values from: signal_peptide
IAO_0000115: An osteocalcin that has had the signal peptide removed but retains the propeptide.
has exact synonym: OCpro
has OBO namespace: protein
id: PR:000024871
comment: Category=modification.

Axiom
annotated source: osteocalcin pro-protein
annotated property: IAO_0000115
annotated target: An osteocalcin that has had the signal peptide removed but retains the propeptide.
has db xref: PRO:DAN

Axiom
annotated source: osteocalcin pro-protein
annotated property: hasExactSynonym
annotated target: OCpro
has db xref: PRO:DAN
has synonym type: PRO-short-label

osteocalcin pro-protein, fully carboyxylated form
type: Class
equivalent class: Class
  intersection of: osteocalcin pro-protein
  intersection of: Restriction
    on property: has_component
    qualified cardinality: 3
    on class: L-gamma-carboxyglutamic acid
IAO_0000115: An osteocalcin pro-protein that has been carboxylated on all three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818. Example: UniProtKB:P02818, 24-100, Glu-68/Glu-72/Glu-75, MOD:00041.
has exact synonym: cOC-pro
has OBO namespace: protein
id: PR:000024883
comment: Category=modification.

Axiom
annotated source: osteocalcin pro-protein, fully carboyxylated form
annotated property: IAO_0000115
annotated target: An osteocalcin pro-protein that has been carboxylated on all three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818. Example: UniProtKB:P02818, 24-100, Glu-68/Glu-72/Glu-75, MOD:00041.
has db xref: PRO:DAN

Axiom
annotated source: osteocalcin pro-protein, fully carboyxylated form
annotated property: hasExactSynonym
annotated target: cOC-pro
has db xref: PRO:DAN
has synonym type: PRO-short-label

osteocalcin pro-protein, undercarboyxylated form
type: Class
equivalent class: Class
  intersection of: osteocalcin pro-protein
  intersection of: Restriction
    on property: has_component
    min qualified cardinality: 1
    on class: L-gamma-carboxyglutamic acid
  intersection of: Restriction
    on property: has_component
    max qualified cardinality: 2
    on class: L-gamma-carboxyglutamic acid
IAO_0000115: An osteocalcin pro-protein that has been carboxylated on 1-2 of the three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818.
has exact synonym: ucOC-pro
has OBO namespace: protein
id: PR:000024901
comment: Category=modification.

Axiom
annotated source: osteocalcin pro-protein, undercarboyxylated form
annotated property: IAO_0000115
annotated target: An osteocalcin pro-protein that has been carboxylated on 1-2 of the three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818.
has db xref: PRO:DAN

Axiom
annotated source: osteocalcin pro-protein, undercarboyxylated form
annotated property: hasExactSynonym
annotated target: ucOC-pro
has db xref: PRO:DAN
has synonym type: PRO-short-label

osteocalcin pro-protein, uncarboyxylated form
type: Class
equivalent class: Class
  intersection of: osteocalcin pro-protein
  intersection of: Restriction
    on property: lacks_part
    some values from: L-gamma-carboxyglutamic acid
IAO_0000115: An osteocalcin pro-protein that has not been carboxylated on any of the three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818. Example: UniProtKB:P02818, 24-100, Glu-68/Glu-72/Glu-75, PR:000026291.
has exact synonym: OCuc-pro
has OBO namespace: protein
id: PR:000024914
comment: Category=modification.

Axiom
annotated source: osteocalcin pro-protein, uncarboyxylated form
annotated property: IAO_0000115
annotated target: An osteocalcin pro-protein that has not been carboxylated on any of the three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818. Example: UniProtKB:P02818, 24-100, Glu-68/Glu-72/Glu-75, PR:000026291.
has db xref: PRO:DAN

Axiom
annotated source: osteocalcin pro-protein, uncarboyxylated form
annotated property: hasExactSynonym
annotated target: OCuc-pro
has db xref: PRO:DAN
has synonym type: PRO-short-label

osteocalcin peptide
type: Class
equivalent class: Class
  intersection of: osteocalcin
  intersection of: Restriction
    on property: lacks_part
    some values from: signal_peptide
  intersection of: Restriction
    on property: lacks_part
    some values from: propeptide
IAO_0000115: An osteocalcin that has had both the signal peptide and the propeptide removed.
has exact synonym: OC
has OBO namespace: protein
id: PR:000024920
comment: Category=modification.

Axiom
annotated source: osteocalcin peptide
annotated property: IAO_0000115
annotated target: An osteocalcin that has had both the signal peptide and the propeptide removed.
has db xref: PRO:DAN

Axiom
annotated source: osteocalcin peptide
annotated property: hasExactSynonym
annotated target: OC
has db xref: PRO:DAN
has synonym type: PRO-short-label

osteocalcin peptide, fully carboyxylated form
type: Class
equivalent class: Class
  intersection of: osteocalcin peptide
  intersection of: Restriction
    on property: has_component
    qualified cardinality: 3
    on class: L-gamma-carboxyglutamic acid
IAO_0000115: An osteocalcin peptide that has been carboxylated on all three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818. Example: UniProtKB:P02818, 52-100, Glu-68/Glu-72/Glu-75, MOD:00041.
has exact synonym: cOC
has OBO namespace: protein
id: PR:000024923
comment: Category=modification.

Axiom
annotated source: osteocalcin peptide, fully carboyxylated form
annotated property: IAO_0000115
annotated target: An osteocalcin peptide that has been carboxylated on all three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818. Example: UniProtKB:P02818, 52-100, Glu-68/Glu-72/Glu-75, MOD:00041.
has db xref: PRO:DAN

Axiom
annotated source: osteocalcin peptide, fully carboyxylated form
annotated property: hasExactSynonym
annotated target: cOC
has db xref: PRO:DAN
has synonym type: PRO-short-label

osteocalcin peptide, undercarboyxylated form
type: Class
equivalent class: Class
  intersection of: osteocalcin peptide
  intersection of: Restriction
    on property: has_component
    min qualified cardinality: 1
    on class: L-gamma-carboxyglutamic acid
  intersection of: Restriction
    on property: has_component
    max qualified cardinality: 2
    on class: L-gamma-carboxyglutamic acid
IAO_0000115: An osteocalcin peptide that has been carboxylated on 1-2 of the three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818.
has exact synonym: ucOC
has OBO namespace: protein
id: PR:000024926
comment: Category=modification.

Axiom
annotated source: osteocalcin peptide, undercarboyxylated form
annotated property: IAO_0000115
annotated target: An osteocalcin peptide that has been carboxylated on 1-2 of the three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818.
has db xref: PRO:DAN

Axiom
annotated source: osteocalcin peptide, undercarboyxylated form
annotated property: hasExactSynonym
annotated target: ucOC
has db xref: PRO:DAN
has synonym type: PRO-short-label

osteocalcin peptide, uncarboyxylated form
type: Class
equivalent class: Class
  intersection of: osteocalcin peptide
  intersection of: Restriction
    on property: lacks_part
    some values from: L-gamma-carboxyglutamic acid
IAO_0000115: An osteocalcin peptide that has not been carboxylated on any of the three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818. Example: UniProtKB:P02818, 52-100, Glu-68/Glu-72/Glu-75, PR:000026291.
has exact synonym: OCuc
has OBO namespace: protein
id: PR:000024932
comment: Category=modification.

Axiom
annotated source: osteocalcin peptide, uncarboyxylated form
annotated property: IAO_0000115
annotated target: An osteocalcin peptide that has not been carboxylated on any of the three eligible residues, corresponding to Glu-17, Glu-21, and Glu-24 of the human mature peptide UniProtKB:P02818. Example: UniProtKB:P02818, 52-100, Glu-68/Glu-72/Glu-75, PR:000026291.
has db xref: PRO:DAN

Axiom
annotated source: osteocalcin peptide, uncarboyxylated form
annotated property: hasExactSynonym
annotated target: OCuc
has db xref: PRO:DAN
has synonym type: PRO-short-label

modified amino-acid residue
type: Class
subclass of: amino-acid residue
IAO_0000115: An organic group that results from covalent modification or chemical alteration to the side chain or backbone atoms of an amino acid residue or derivative thereof, where such alteration maintains the integrity of the amino acid chain containing the residue.
has exact synonym: modified amino acid chain residue
has narrow synonym: modified protein residue
has OBO namespace: protein
id: PR:000025513
comment: Category=external. Note: This entity is distinct from MOD:00000 "protein modification" in that the latter includes proteolytic cleavages. [PRO:DAN, PRO:JSG]

Axiom
annotated source: modified amino-acid residue
annotated property: IAO_0000115
annotated target: An organic group that results from covalent modification or chemical alteration to the side chain or backbone atoms of an amino acid residue or derivative thereof, where such alteration maintains the integrity of the amino acid chain containing the residue.
has db xref: PRO:DAN
has db xref: PRO:JSG

Axiom
annotated source: modified amino-acid residue
annotated property: hasExactSynonym
annotated target: modified amino acid chain residue
has db xref: PRO:DAN

Axiom
annotated source: modified amino-acid residue
annotated property: hasNarrowSynonym
annotated target: modified protein residue
has db xref: PRO:DAN

T-cell-specific surface glycoprotein CD28 isoform 1
type: Class
subclass of: T-cell-specific surface glycoprotein CD28
IAO_0000115: A T-cell-specific surface glycoprotein CD28 that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P10747-1 or a 1:1 ortholog thereof.
has archetype: T-cell-specific surface glycoprotein CD28 isoform 1 (human)
has exact synonym: CD28/iso:1
has OBO namespace: protein
id: PR:000025788
comment: Category=sequence.

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1
annotated property: IAO_0000115
annotated target: A T-cell-specific surface glycoprotein CD28 that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P10747-1 or a 1:1 ortholog thereof.
has db xref: PRO:CNA

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1
annotated property: hasExactSynonym
annotated target: CD28/iso:1
has db xref: PRO:DNx
has synonym type: PRO-short-label

T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1
type: Class
subclass of: T-cell-specific surface glycoprotein CD28 isoform 1
subclass of: Restriction
  on property: has_part
  some values from: O4'-phospho-L-tyrosine
subclass of: Restriction
  on property: lacks_part
  some values from: signal_peptide
IAO_0000115: A T-cell-specific surface glycoprotein CD28 isoform 1 that has had the signal peptide removed and has been phosphorylated on the Tyr residue within the C-terminal YMNM motif by LCK. Example: UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048.
has exact synonym: CD28/iso:1/SigPep-/Phos:1
has OBO namespace: protein
id: PR:000025789
comment: Category=modification.

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1
annotated property: IAO_0000115
annotated target: A T-cell-specific surface glycoprotein CD28 isoform 1 that has had the signal peptide removed and has been phosphorylated on the Tyr residue within the C-terminal YMNM motif by LCK. Example: UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048.
has db xref: PMID:8992971
has db xref: PRO:CNA
has db xref: PRO:DAN

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1
annotated property: hasExactSynonym
annotated target: CD28/iso:1/SigPep-/Phos:1
has db xref: PRO:DNx
has synonym type: PRO-short-label

T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
type: Class
equivalent class: Class
  intersection of: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
subclass of: Restriction
  on property: has_part
  some values from: O4'-phospho-L-tyrosine
IAO_0000115: A T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048.
has db xref: Reactome:R-HSA-388756
has exact synonym: PRO_0000014652, Tyr-191, MOD:00048
has exact synonym: UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048
has exact synonym: hCD28/iso:1/SigPep-/Phos:1
has OBO namespace: protein
id: PR:000025790
comment: Category=organism-modification.

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
annotated property: IAO_0000115
annotated target: A T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048.
has db xref: PMID:8992971
has db xref: PRO:CNA

PR:000025790 located_in GO:0005886
type: Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-388756

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
annotated property: hasExactSynonym
annotated target: PRO_0000014652, Tyr-191, MOD:00048
has db xref: PRO:DNx
has synonym type: PRO-proteoform-ftid

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
annotated property: hasExactSynonym
annotated target: UniProtKB:P10747-1, 19-220, Tyr-191, MOD:00048
has db xref: PRO:DNx
has synonym type: PRO-proteoform-std

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
annotated property: hasExactSynonym
annotated target: hCD28/iso:1/SigPep-/Phos:1
has db xref: PRO:DNx
has synonym type: PRO-short-label

phospho CD28 homodimer
type: Class
equivalent class: Class
  intersection of: protein-containing complex
  intersection of: Restriction
    on property: has_component
    qualified cardinality: 2
    on class: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1
IAO_0000115: A protein complex that is composed of two copies of phosphorylated CD28.
has exact synonym: (CD28/iso:1/SigPep-/Phos:1)*2
has OBO namespace: protein
id: PR:000025791
comment: Category=complex.

Axiom
annotated source: phospho CD28 homodimer
annotated property: IAO_0000115
annotated target: A protein complex that is composed of two copies of phosphorylated CD28.
has db xref: PMID:8992971
has db xref: PRO:CNA

Axiom
annotated source: phospho CD28 homodimer
annotated property: hasExactSynonym
annotated target: (CD28/iso:1/SigPep-/Phos:1)*2
has db xref: PRO:DAN
has synonym type: PRO-short-label

phospho CD28 homodimer (human)
type: Class
subclass of: phospho CD28 homodimer
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
subclass of: Restriction
  on property: has_component
  qualified cardinality: 2
  on class: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed phosphorylated 1 (human)
IAO_0000115: A phospho CD28 homodimer whose components are encoded in the genome of human.
has exact synonym: h(CD28/iso:1/SigPep-/Phos:1)*2
has OBO namespace: protein
id: PR:000025792
comment: Category=organism-complex.

Axiom
annotated source: phospho CD28 homodimer (human)
annotated property: IAO_0000115
annotated target: A phospho CD28 homodimer whose components are encoded in the genome of human.
has db xref: PMID:8992971
has db xref: PRO:CNA

Axiom
annotated source: phospho CD28 homodimer (human)
annotated property: hasExactSynonym
annotated target: h(CD28/iso:1/SigPep-/Phos:1)*2
has db xref: PRO:DAN
has synonym type: PRO-short-label

T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed form
type: Class
equivalent class: Class
  intersection of: T-cell-specific surface glycoprotein CD28 isoform 1
  intersection of: Restriction
    on property: lacks_part
    some values from: signal_peptide
IAO_0000115: A T-cell-specific surface glycoprotein CD28 isoform 1 that has had the signal peptide removed.
has exact synonym: CD28/iso:1/SigPep-
has OBO namespace: protein
id: PR:000026613
comment: Category=modification.

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed form
annotated property: IAO_0000115
annotated target: A T-cell-specific surface glycoprotein CD28 isoform 1 that has had the signal peptide removed.
has db xref: PRO:DNx

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1, signal peptide removed form
annotated property: hasExactSynonym
annotated target: CD28/iso:1/SigPep-
has db xref: PRO:DNx
has synonym type: PRO-short-label

T-cell-specific surface glycoprotein CD28, signal peptide removed form (human)
type: Class
equivalent class: Class
  intersection of: T-cell-specific surface glycoprotein CD28, signal peptide removed form
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
IAO_0000115: A T-cell-specific surface glycoprotein CD28, signal peptide removed form in human. Example: UniProtKB:P10747-1, 19-220.
has db xref: Reactome:R-HSA-167628
has db xref: Reactome:R-HSA-167632
has exact synonym: hCD28/SigPep-
has narrow synonym: PRO_0000014652
has narrow synonym: UniProtKB:P10747-1, 19-220
has OBO namespace: protein
id: PR:000026870
comment: Category=organism-modification.

Axiom
annotated source: T-cell-specific surface glycoprotein CD28, signal peptide removed form (human)
annotated property: IAO_0000115
annotated target: A T-cell-specific surface glycoprotein CD28, signal peptide removed form in human. Example: UniProtKB:P10747-1, 19-220.
has db xref: PRO:CNA
has db xref: Reactome:R-HSA-167628
has db xref: Reactome:R-HSA-167632

PR:000026870 located_in GO:0005829
type: Axiom
annotated source: T-cell-specific surface glycoprotein CD28, signal peptide removed form (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167628

PR:000026870 located_in GO:0005886
type: Axiom
annotated source: T-cell-specific surface glycoprotein CD28, signal peptide removed form (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-167632

Axiom
annotated source: T-cell-specific surface glycoprotein CD28, signal peptide removed form (human)
annotated property: hasExactSynonym
annotated target: hCD28/SigPep-
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: T-cell-specific surface glycoprotein CD28, signal peptide removed form (human)
annotated property: hasNarrowSynonym
annotated target: PRO_0000014652
has db xref: PRO:DNx
has synonym type: PRO-proteoform-ftid

Axiom
annotated source: T-cell-specific surface glycoprotein CD28, signal peptide removed form (human)
annotated property: hasNarrowSynonym
annotated target: UniProtKB:P10747-1, 19-220
has db xref: PRO:DNx
has synonym type: PRO-proteoform-std

Homo sapiens protein
type: Class
equivalent class: Class
  intersection of: protein
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
IAO_0000115: A protein that is encoded in the genome of Homo sapiens.
has exact synonym: human protein
has OBO namespace: protein
id: PR:000029067

Axiom
annotated source: Homo sapiens protein
annotated property: IAO_0000115
annotated target: A protein that is encoded in the genome of Homo sapiens.
has db xref: PRO:DAN

Axiom
annotated source: Homo sapiens protein
annotated property: hasExactSynonym
annotated target: human protein
has db xref: PRO:DAN
has synonym type: PRO-short-label

osteocalcin
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of the human BGLAP gene or a 1:1 ortholog thereof.
has archetype: osteocalcin (human)
has exact synonym: BGLAP
has exact synonym: BGP
has exact synonym: bone Gla protein
has exact synonym: gamma-carboxyglutamic acid-containing protein
has OBO namespace: protein
id: PR:000030444
comment: Category=gene.

Axiom
annotated source: osteocalcin
annotated property: IAO_0000115
annotated target: A protein that is a translation product of the human BGLAP gene or a 1:1 ortholog thereof.
has db xref: PRO:DNx

Axiom
annotated source: osteocalcin
annotated property: hasExactSynonym
annotated target: BGLAP
has db xref: PRO:DNx
has synonym type: PRO-short-label

eukaryotic protein
type: Class
equivalent class: Class
  intersection of: protein
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Eukaryota
IAO_0000115: A protein that is encoded in the genome of some Eukaryota.
has exact synonym: Eukaryota protein
has OBO namespace: protein
id: PR:000036194

Axiom
annotated source: eukaryotic protein
annotated property: IAO_0000115
annotated target: A protein that is encoded in the genome of some Eukaryota.
has db xref: PRO:DAN

Axiom
annotated source: eukaryotic protein
annotated property: hasExactSynonym
annotated target: Eukaryota protein
has db xref: PRO:DAN

phosphoprotein
type: Class
equivalent class: Class
  intersection of: protein
  intersection of: Restriction
    on property: has_part
    some values from: phosphorylated residue
IAO_0000115: A protein that includes at least one phosphorylated residue.
has exact synonym: Prot/PhosRes+
has exact synonym: phosphorylated protein
has OBO namespace: protein
id: PR:000037070
comment: Category=modification.

Axiom
annotated source: phosphoprotein
annotated property: IAO_0000115
annotated target: A protein that includes at least one phosphorylated residue.
has db xref: PRO:DAN

Axiom
annotated source: phosphoprotein
annotated property: hasExactSynonym
annotated target: Prot/PhosRes+
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: phosphoprotein
annotated property: hasExactSynonym
annotated target: phosphorylated protein
has db xref: PRO:DAN

carboxylated protein
type: Class
equivalent class: Class
  intersection of: protein
  intersection of: Restriction
    on property: has_part
    some values from: carboxylated residue
IAO_0000115: A protein that includes at least one carboxylated residue.
has exact synonym: Prot/CbxRes+
has OBO namespace: protein
id: PR:000037080
comment: Category=modification.

Axiom
annotated source: carboxylated protein
annotated property: IAO_0000115
annotated target: A protein that includes at least one carboxylated residue.
has db xref: PRO:DAN

Axiom
annotated source: carboxylated protein
annotated property: hasExactSynonym
annotated target: Prot/CbxRes+
has db xref: PRO:DAN
has synonym type: PRO-short-label

osteocalcin, signal peptide removed form (human)
type: Class
equivalent class: Class
  intersection of: osteocalcin (human)
  intersection of: Restriction
    on property: lacks_part
    some values from: signal_peptide
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: An osteocalcin (human) that has had the signal peptide removed. UniProtKB:P02818, 24-100.
has db xref: Reactome:R-HSA-6807212
has exact synonym: UniProtKB:P02818, 24-100
has exact synonym: hBGLAP/SigPep-
has OBO namespace: protein
id: PR:000046480
comment: Category=organism-modification.

Axiom
annotated source: osteocalcin, signal peptide removed form (human)
annotated property: IAO_0000115
annotated target: An osteocalcin (human) that has had the signal peptide removed. UniProtKB:P02818, 24-100.
has db xref: PRO:DNx
has db xref: Reactome:R-HSA-6807212

PR:000046480 located_in GO:0005788
type: Axiom
annotated source: osteocalcin, signal peptide removed form (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-6807212

Axiom
annotated source: osteocalcin, signal peptide removed form (human)
annotated property: hasExactSynonym
annotated target: UniProtKB:P02818, 24-100
has db xref: PRO:DNx
has synonym type: PRO-proteoform-std

Axiom
annotated source: osteocalcin, signal peptide removed form (human)
annotated property: hasExactSynonym
annotated target: hBGLAP/SigPep-
has db xref: PRO:DNx
has synonym type: PRO-short-label

collagen alpha-1(V) chain 3-hydroxy-proline and 4-hydroxy-proline form (human)
type: Class
equivalent class: Class
  intersection of: collagen alpha-1(V) chain (human)
  intersection of: Restriction
    on property: has_part
    some values from: 3-hydroxy-L-proline
  intersection of: Restriction
    on property: has_part
    some values from: 4-hydroxy-L-proline
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A collagen alpha-1(V) chain (human) that includes at least one 3-hydroxy-proline and at least one 4-hydroxy-proline. UniProtKB:P20908, MOD:00038|MOD:00039.
has db xref: Reactome:R-HSA-2268730
has exact synonym: UniProtKB:P20908, MOD:00038|MOD:00039
has exact synonym: hCOL5A1/3hP4hP+
has OBO namespace: protein
id: PR:000046928
comment: Category=organism-modification.

Axiom
annotated source: collagen alpha-1(V) chain 3-hydroxy-proline and 4-hydroxy-proline form (human)
annotated property: IAO_0000115
annotated target: A collagen alpha-1(V) chain (human) that includes at least one 3-hydroxy-proline and at least one 4-hydroxy-proline. UniProtKB:P20908, MOD:00038|MOD:00039.
has db xref: PRO:DNx
has db xref: Reactome:R-HSA-2268730

PR:000046928 located_in GO:0005576
type: Axiom
annotated source: collagen alpha-1(V) chain 3-hydroxy-proline and 4-hydroxy-proline form (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2268730

Axiom
annotated source: collagen alpha-1(V) chain 3-hydroxy-proline and 4-hydroxy-proline form (human)
annotated property: hasExactSynonym
annotated target: UniProtKB:P20908, MOD:00038|MOD:00039
has db xref: PRO:DNx
has synonym type: PRO-proteoform-std

Axiom
annotated source: collagen alpha-1(V) chain 3-hydroxy-proline and 4-hydroxy-proline form (human)
annotated property: hasExactSynonym
annotated target: hCOL5A1/3hP4hP+
has db xref: PRO:DNx
has synonym type: PRO-short-label

collagen alpha-1(V) chain 4-hydroxy-proline form (human)
type: Class
equivalent class: Class
  intersection of: collagen alpha-1(V) chain (human)
  intersection of: Restriction
    on property: has_part
    some values from: 4-hydroxy-L-proline
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A collagen alpha-1(V) chain (human) that includes at least one 4-hydroxy-proline. UniProtKB:P20908, MOD:00039.
has db xref: Reactome:R-HSA-2268810
has exact synonym: UniProtKB:P20908, MOD:00039
has exact synonym: hCOL5A1/4HyPro+
has OBO namespace: protein
id: PR:000046929
comment: Category=organism-modification.

Axiom
annotated source: collagen alpha-1(V) chain 4-hydroxy-proline form (human)
annotated property: IAO_0000115
annotated target: A collagen alpha-1(V) chain (human) that includes at least one 4-hydroxy-proline. UniProtKB:P20908, MOD:00039.
has db xref: PRO:DNx
has db xref: Reactome:R-HSA-2268810

PR:000046929 located_in GO:0005576
type: Axiom
annotated source: collagen alpha-1(V) chain 4-hydroxy-proline form (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2268810

Axiom
annotated source: collagen alpha-1(V) chain 4-hydroxy-proline form (human)
annotated property: hasExactSynonym
annotated target: UniProtKB:P20908, MOD:00039
has db xref: PRO:DNx
has synonym type: PRO-proteoform-std

Axiom
annotated source: collagen alpha-1(V) chain 4-hydroxy-proline form (human)
annotated property: hasExactSynonym
annotated target: hCOL5A1/4HyPro+
has db xref: PRO:DNx
has synonym type: PRO-short-label

collagen alpha-1(V) chain, signal peptide removed form (human)
type: Class
equivalent class: Class
  intersection of: collagen alpha-1(V) chain (human)
  intersection of: Restriction
    on property: lacks_part
    some values from: signal_peptide
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A collagen alpha-1(V) chain (human) that has had the signal peptide removed. UniProtKB:P20908, 38-1838.
has db xref: Reactome:R-HSA-2022460
has db xref: Reactome:R-HSA-2268703
has exact synonym: UniProtKB:P20908, 38-1838
has exact synonym: hCOL5A1/SigPep-
has OBO namespace: protein
id: PR:000046933
comment: Category=organism-modification.

Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed form (human)
annotated property: IAO_0000115
annotated target: A collagen alpha-1(V) chain (human) that has had the signal peptide removed. UniProtKB:P20908, 38-1838.
has db xref: PRO:DNx
has db xref: Reactome:R-HSA-2022460
has db xref: Reactome:R-HSA-2268703

PR:000046933 located_in GO:0005788
type: Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed form (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022460

PR:000046933 located_in GO:0005576
type: Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed form (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2268703

Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed form (human)
annotated property: hasExactSynonym
annotated target: UniProtKB:P20908, 38-1838
has db xref: PRO:DNx
has synonym type: PRO-proteoform-std

Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed form (human)
annotated property: hasExactSynonym
annotated target: hCOL5A1/SigPep-
has db xref: PRO:DNx
has synonym type: PRO-short-label

collagen alpha-1(V) chain, signal peptide removed 3-hydroxy-proline and 4-hydroxy-proline form (human)
type: Class
equivalent class: Class
  intersection of: collagen alpha-1(V) chain (human)
  intersection of: Restriction
    on property: has_part
    some values from: 3-hydroxy-L-proline
  intersection of: Restriction
    on property: lacks_part
    some values from: signal_peptide
  intersection of: Restriction
    on property: has_component
    min qualified cardinality: 3
    on class: 4-hydroxy-L-proline
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A collagen alpha-1(V) chain (human) that has had the signal peptide removed and that includes at least one 3-hydroxy-proline and at least three 4-hydroxy-prolines. UniProtKB:P20908, 38-1838, MOD:00038|MOD:00039(3+).
has db xref: Reactome:R-HSA-2022483
has db xref: Reactome:R-HSA-2268667
has exact synonym: UniProtKB:P20908, 38-1838, MOD:00038|MOD:00039(3+)
has exact synonym: hCOL5A1/SigPep-/3HyPro4HyPro(3+)
has OBO namespace: protein
id: PR:000046934
comment: Category=organism-modification.

Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed 3-hydroxy-proline and 4-hydroxy-proline form (human)
annotated property: IAO_0000115
annotated target: A collagen alpha-1(V) chain (human) that has had the signal peptide removed and that includes at least one 3-hydroxy-proline and at least three 4-hydroxy-prolines. UniProtKB:P20908, 38-1838, MOD:00038|MOD:00039(3+).
has db xref: PRO:DNx
has db xref: Reactome:R-HSA-2022483
has db xref: Reactome:R-HSA-2268667

PR:000046934 located_in GO:0005788
type: Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed 3-hydroxy-proline and 4-hydroxy-proline form (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022483

PR:000046934 located_in GO:0005576
type: Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed 3-hydroxy-proline and 4-hydroxy-proline form (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2268667

Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed 3-hydroxy-proline and 4-hydroxy-proline form (human)
annotated property: hasExactSynonym
annotated target: UniProtKB:P20908, 38-1838, MOD:00038|MOD:00039(3+)
has db xref: PRO:DNx
has synonym type: PRO-proteoform-std

Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed 3-hydroxy-proline and 4-hydroxy-proline form (human)
annotated property: hasExactSynonym
annotated target: hCOL5A1/SigPep-/3HyPro4HyPro(3+)
has db xref: PRO:DNx
has synonym type: PRO-short-label

collagen alpha-1(V) chain, signal peptide removed 4-hydroxy-proline form (human)
type: Class
equivalent class: Class
  intersection of: collagen alpha-1(V) chain (human)
  intersection of: Restriction
    on property: has_part
    some values from: 4-hydroxy-L-proline
  intersection of: Restriction
    on property: lacks_part
    some values from: signal_peptide
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A collagen alpha-1(V) chain (human) that has had the signal peptide removed and that includes at least one 4-hydroxy-proline. UniProtKB:P20908, 38-1838, MOD:00039.
has db xref: Reactome:R-HSA-2022510
has db xref: Reactome:R-HSA-2268658
has exact synonym: UniProtKB:P20908, 38-1838, MOD:00039
has exact synonym: hCOL5A1/SigPep-/4HyPro+
has OBO namespace: protein
id: PR:000046935
comment: Category=organism-modification.

Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed 4-hydroxy-proline form (human)
annotated property: IAO_0000115
annotated target: A collagen alpha-1(V) chain (human) that has had the signal peptide removed and that includes at least one 4-hydroxy-proline. UniProtKB:P20908, 38-1838, MOD:00039.
has db xref: PRO:DNx
has db xref: Reactome:R-HSA-2022510
has db xref: Reactome:R-HSA-2268658

PR:000046935 located_in GO:0005788
type: Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed 4-hydroxy-proline form (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2022510

PR:000046935 located_in GO:0005576
type: Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed 4-hydroxy-proline form (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2268658

Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed 4-hydroxy-proline form (human)
annotated property: hasExactSynonym
annotated target: UniProtKB:P20908, 38-1838, MOD:00039
has db xref: PRO:DNx
has synonym type: PRO-proteoform-std

Axiom
annotated source: collagen alpha-1(V) chain, signal peptide removed 4-hydroxy-proline form (human)
annotated property: hasExactSynonym
annotated target: hCOL5A1/SigPep-/4HyPro+
has db xref: PRO:DNx
has synonym type: PRO-short-label

amino-acid residue related to L-glutamic acid
type: Class
equivalent class: Class
  union of: L-glutamic acid residue
  union of: modified L-glutamic acid residue
subclass of: amino-acid residue
IAO_0000115: An amino-acid residue that is either a modified or unmodified L-glutamic acid residue.
has OBO namespace: protein
id: PR:000049915
comment: Category=external.

Axiom
annotated source: amino-acid residue related to L-glutamic acid
annotated property: IAO_0000115
annotated target: An amino-acid residue that is either a modified or unmodified L-glutamic acid residue.
has db xref: PRO:DAN

amino-acid residue related to L-proline
type: Class
equivalent class: Class
  union of: L-proline residue
  union of: modified L-proline residue
subclass of: amino-acid residue
IAO_0000115: An amino-acid residue that is either a modified or unmodified L-proline residue.
has OBO namespace: protein
id: PR:000049924
comment: Category=external.

Axiom
annotated source: amino-acid residue related to L-proline
annotated property: IAO_0000115
annotated target: An amino-acid residue that is either a modified or unmodified L-proline residue.
has db xref: PRO:DAN

amino-acid residue related to L-tyrosine
type: Class
equivalent class: Class
  union of: L-tyrosine residue
  union of: modified L-tyrosine residue
subclass of: amino-acid residue
IAO_0000115: An amino-acid residue that is either a modified or unmodified L-tyrosine residue.
has OBO namespace: protein
id: PR:000049928
comment: Category=external.

Axiom
annotated source: amino-acid residue related to L-tyrosine
annotated property: IAO_0000115
annotated target: An amino-acid residue that is either a modified or unmodified L-tyrosine residue.
has db xref: PRO:DAN

IgA1 immunoglobulin complex, circulating (human)
type: Class
subclass of: IgA immunoglobulin complex, circulating
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
subclass of: Restriction
  on property: has_component
  some values from: immunoglobulin light chain protein (human)
subclass of: Restriction
  on property: has_component
  some values from: IgA1 heavy chain protein, secretory isoform (human)
IAO_0000115: An IgA immunoglobulin complex, circulating that in monomeric form is composed of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
has broad synonym: IgA antibody (human)
has exact synonym: IgA1 antibody (human)
has exact synonym: hIgA1/circulating
has OBO namespace: protein
id: PR:000050159
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL.

Axiom
annotated source: IgA1 immunoglobulin complex, circulating (human)
annotated property: IAO_0000115
annotated target: An IgA immunoglobulin complex, circulating that in monomeric form is composed of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
has db xref: GOC:add
has db xref: ISBN:0781765196
has db xref: PMID:16362985
has db xref: PRO:ADD

Axiom
annotated source: IgA1 immunoglobulin complex, circulating (human)
annotated property: hasBroadSynonym
annotated target: IgA antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: IgA1 immunoglobulin complex, circulating (human)
annotated property: hasExactSynonym
annotated target: IgA1 antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: IgA1 immunoglobulin complex, circulating (human)
annotated property: hasExactSynonym
annotated target: hIgA1/circulating
has db xref: PRO:DAN
has synonym type: PRO-short-label

monomeric IgA1 immunoglobulin complex (human)
type: Class
subclass of: IgA1 immunoglobulin complex, circulating (human)
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
subclass of: Restriction
  on property: has_component
  qualified cardinality: 2
  on class: immunoglobulin light chain protein (human)
subclass of: Restriction
  on property: has_component
  qualified cardinality: 2
  on class: IgA1 heavy chain protein, secretory isoform (human)
IAO_0000115: An IgA1 immunoglobulin complex, circulating (human) that is composed of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
has broad synonym: monomeric IgA antibody (human)
has exact synonym: h(IgA1)monomeric
has exact synonym: monomeric IgA1 antibody (human)
has OBO namespace: protein
id: PR:000050163
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL.

Axiom
annotated source: monomeric IgA1 immunoglobulin complex (human)
annotated property: IAO_0000115
annotated target: An IgA1 immunoglobulin complex, circulating (human) that is composed of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
has db xref: GOC:add
has db xref: ISBN:0781765196
has db xref: PMID:16362985
has db xref: PRO:ADD

Axiom
annotated source: monomeric IgA1 immunoglobulin complex (human)
annotated property: hasBroadSynonym
annotated target: monomeric IgA antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: monomeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: h(IgA1)monomeric
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: monomeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: monomeric IgA1 antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

polymeric IgA1 immunoglobulin complex (human)
type: Class
equivalent class: Class
  intersection of: IgA1 immunoglobulin complex, circulating (human)
  intersection of: Restriction
    on property: has_component
    min qualified cardinality: 2
    on class: monomeric IgA1 immunoglobulin complex (human)
  intersection of: Restriction
    on property: has_component
    qualified cardinality: 1
    on class: immunoglobulin J chain (human)
  intersection of: Restriction
    on property: has_component
    max qualified cardinality: 4
    on class: monomeric IgA1 immunoglobulin complex (human)
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: An IgA1 immunoglobulin complex, circulating (human) that is composed of two, three, or four monomeric IgA1 immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
has broad synonym: pIgA antibody (human)
has broad synonym: polymeric IgA antibody (human)
has exact synonym: h(IgA1)polymeric
has exact synonym: pIgA1 antibody (human)
has exact synonym: polymeric IgA1 antibody (human)
has OBO namespace: protein
id: PR:000050165
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. Dimeric IgA1 is by far the most common form of polymeric IgA1. In human only the IgA1 isotype is capable of a polymeric forms.

Axiom
annotated source: polymeric IgA1 immunoglobulin complex (human)
annotated property: IAO_0000115
annotated target: An IgA1 immunoglobulin complex, circulating (human) that is composed of two, three, or four monomeric IgA1 immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
has db xref: GOC:add
has db xref: ISBN:0781765196
has db xref: PMID:16362985
has db xref: PRO:ADD

Axiom
annotated source: polymeric IgA1 immunoglobulin complex (human)
annotated property: hasBroadSynonym
annotated target: pIgA antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: polymeric IgA1 immunoglobulin complex (human)
annotated property: hasBroadSynonym
annotated target: polymeric IgA antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: polymeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: h(IgA1)polymeric
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: polymeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: pIgA1 antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: polymeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: polymeric IgA1 antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

dimeric IgA1 immunoglobulin complex (human)
type: Class
equivalent class: Class
  intersection of: polymeric IgA1 immunoglobulin complex (human)
  intersection of: Restriction
    on property: has_component
    qualified cardinality: 1
    on class: immunoglobulin J chain (human)
  intersection of: Restriction
    on property: has_component
    qualified cardinality: 2
    on class: monomeric IgA1 immunoglobulin complex (human)
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A polymeric IgA1 immunoglobulin complex (human) that is composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
has broad synonym: dimeric IgA antibody (human)
has exact synonym: dimeric IgA1 antibody (human)
has exact synonym: h(IgA1)dimeric
has OBO namespace: protein
id: PR:000050166
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. Dimeric IgA1 is by far the most common form of polymeric IgA1. In human only the IgA1 isotype is capable of a dimeric form.

Axiom
annotated source: dimeric IgA1 immunoglobulin complex (human)
annotated property: IAO_0000115
annotated target: A polymeric IgA1 immunoglobulin complex (human) that is composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
has db xref: GOC:add
has db xref: ISBN:0781765196
has db xref: PMID:16362985
has db xref: PRO:ADD

Axiom
annotated source: dimeric IgA1 immunoglobulin complex (human)
annotated property: hasBroadSynonym
annotated target: dimeric IgA antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: dimeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: dimeric IgA1 antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: dimeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: h(IgA1)dimeric
has db xref: PRO:DAN
has synonym type: PRO-short-label

secretory polymeric IgA1 immunoglobulin complex (human)
type: Class
equivalent class: Class
  intersection of: polymeric IgA1 immunoglobulin complex (human)
  intersection of: Restriction
    on property: has_component
    some values from: polymeric immunoglobulin receptor secretory component (human)
  intersection of: Restriction
    on property: has_component
    min qualified cardinality: 2
    on class: monomeric IgA1 immunoglobulin complex (human)
  intersection of: Restriction
    on property: has_component
    qualified cardinality: 1
    on class: immunoglobulin J chain (human)
  intersection of: Restriction
    on property: has_component
    max qualified cardinality: 4
    on class: monomeric IgA1 immunoglobulin complex (human)
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A polymeric IgA1 immunoglobulin complex (human) that is complexed with one chain of secretory component (SC). Polymeric IgA1 is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component.
has broad synonym: sIgA antibody (human)
has broad synonym: secretory IgA antibody (human)
has exact synonym: h(IgA1/secretory)polymeric
has exact synonym: sIgA1 antibody (human)
has exact synonym: secretory IgA1 antibody (human)
has OBO namespace: protein
id: PR:000050167
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA.

Axiom
annotated source: secretory polymeric IgA1 immunoglobulin complex (human)
annotated property: IAO_0000115
annotated target: A polymeric IgA1 immunoglobulin complex (human) that is complexed with one chain of secretory component (SC). Polymeric IgA1 is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component.
has db xref: GOC:add
has db xref: ISBN:0781765196
has db xref: PMID:16362985
has db xref: PRO:ADD

Axiom
annotated source: secretory polymeric IgA1 immunoglobulin complex (human)
annotated property: hasBroadSynonym
annotated target: sIgA antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: secretory polymeric IgA1 immunoglobulin complex (human)
annotated property: hasBroadSynonym
annotated target: secretory IgA antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: secretory polymeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: h(IgA1/secretory)polymeric
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: secretory polymeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: sIgA1 antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: secretory polymeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: secretory IgA1 antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

secretory dimeric IgA1 immunoglobulin complex (human)
type: Class
equivalent class: Class
  intersection of: polymeric IgA1 immunoglobulin complex (human)
  intersection of: Restriction
    on property: has_component
    some values from: polymeric immunoglobulin receptor secretory component (human)
  intersection of: Restriction
    on property: has_component
    some values from: immunoglobulin J chain (human)
  intersection of: Restriction
    on property: has_component
    qualified cardinality: 2
    on class: monomeric IgA1 immunoglobulin complex (human)
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: A dimeric form of secretory IgA1 immunoglobulin complex.
has broad synonym: secretory dimeric IgA antibody (human)
has exact synonym: h(IgA1/secretory)dimeric
has exact synonym: secretory dimeric IgA1 antibody (human)
has OBO namespace: protein
id: PR:000050168
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. Note that an IgA1 immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA1 is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form.

Axiom
annotated source: secretory dimeric IgA1 immunoglobulin complex (human)
annotated property: IAO_0000115
annotated target: A dimeric form of secretory IgA1 immunoglobulin complex.
has db xref: GOC:add
has db xref: ISBN:0781765196
has db xref: PMID:16362985
has db xref: PRO:ADD

Axiom
annotated source: secretory dimeric IgA1 immunoglobulin complex (human)
annotated property: hasBroadSynonym
annotated target: secretory dimeric IgA antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: secretory dimeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: h(IgA1/secretory)dimeric
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: secretory dimeric IgA1 immunoglobulin complex (human)
annotated property: hasExactSynonym
annotated target: secretory dimeric IgA1 antibody (human)
has db xref: GOC:add
has db xref: PRO:ADD

polymeric immunoglobulin receptor secretory component (human)
type: Class
equivalent class: Class
  intersection of: polymeric immunoglobulin receptor secretory component
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
IAO_0000115: A polymeric immunoglobulin receptor secretory component in human. UniProtKB:P01833, 19-603.
has exact synonym: PRO_0000014901
has exact synonym: SC (human)
has exact synonym: UniProtKB:P01833, 19-603
has exact synonym: hPIGR/SC
has exact synonym: secretory component (human)
has OBO namespace: protein
id: PR:000050169
comment: Category=organism-modification. Requested by=HIPC. Requested by=CL.

Axiom
annotated source: polymeric immunoglobulin receptor secretory component (human)
annotated property: IAO_0000115
annotated target: A polymeric immunoglobulin receptor secretory component in human. UniProtKB:P01833, 19-603.
has db xref: GOC:add
has db xref: ISBN:0781765196
has db xref: PMID:16362985
has db xref: PRO:ADD
has db xref: UniProtKB:P01833

Axiom
annotated source: polymeric immunoglobulin receptor secretory component (human)
annotated property: hasExactSynonym
annotated target: PRO_0000014901
has db xref: PRO:DNx
has synonym type: PRO-proteoform-ftid

Axiom
annotated source: polymeric immunoglobulin receptor secretory component (human)
annotated property: hasExactSynonym
annotated target: SC (human)
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: polymeric immunoglobulin receptor secretory component (human)
annotated property: hasExactSynonym
annotated target: UniProtKB:P01833, 19-603
has db xref: PRO:DNx
has synonym type: PRO-proteoform-std

Axiom
annotated source: polymeric immunoglobulin receptor secretory component (human)
annotated property: hasExactSynonym
annotated target: hPIGR/SC
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: polymeric immunoglobulin receptor secretory component (human)
annotated property: hasExactSynonym
annotated target: secretory component (human)
has db xref: GOC:add
has db xref: PRO:ADD

immunoglobulin heavy chain protein
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of some mRNA produced by a somatically recombined immunoglobulin heavy chain locus.
has exact synonym: IgH
has OBO namespace: protein
id: PR:000050174
comment: Category=family. Requested by=IEDB. Note: In human, the IgH locus is described by https://www.genenames.org/cgi-bin/genefamilies/set/349. In mouse, the locus is described by MGI:96442.

Axiom
annotated source: immunoglobulin heavy chain protein
annotated property: IAO_0000115
annotated target: A protein that is a translation product of some mRNA produced by a somatically recombined immunoglobulin heavy chain locus.
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: immunoglobulin heavy chain protein
annotated property: hasExactSynonym
annotated target: IgH
has db xref: PRO:DAN
has synonym type: PRO-short-label

immunoglobulin light chain protein
type: Class
subclass of: protein
IAO_0000115: A protein that is a translation product of some mRNA produced by a somatically recombined immunoglobulin light chain locus.
has exact synonym: IgL
has OBO namespace: protein
id: PR:000050175
comment: Category=family. Note: In human, the kappa light chain locus is described by https://www.genenames.org/cgi-bin/genefamilies/set/351, and the lambda light chain locus is described by https://www.genenames.org/cgi-bin/genefamilies/set/353. In mouse, the kappa locus is described by MGI:96494, and the lambda locus is described by MGI:96526.

Axiom
annotated source: immunoglobulin light chain protein
annotated property: IAO_0000115
annotated target: A protein that is a translation product of some mRNA produced by a somatically recombined immunoglobulin light chain locus.
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: immunoglobulin light chain protein
annotated property: hasExactSynonym
annotated target: IgL
has db xref: PRO:DAN
has synonym type: PRO-short-label

IgA heavy chain protein
type: Class
subclass of: immunoglobulin heavy chain protein
IAO_0000115: An immunoglobulin heavy chain protein in which the constant region is encoded either by the IgA1 gene segment or the IgA2 gene segment.
has exact synonym: IgHA
has exact synonym: immunoglobulin A heavy chain
has exact synonym: immunoglobulin alpha heavy chain
has exact synonym: immunoglobulin heavy chain alpha
has OBO namespace: protein
id: PR:000050176
comment: Category=family. Requested by=IEDB.

Axiom
annotated source: IgA heavy chain protein
annotated property: IAO_0000115
annotated target: An immunoglobulin heavy chain protein in which the constant region is encoded either by the IgA1 gene segment or the IgA2 gene segment.
has db xref: PRO:DAN

Axiom
annotated source: IgA heavy chain protein
annotated property: hasExactSynonym
annotated target: IgHA
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: IgA heavy chain protein
annotated property: hasExactSynonym
annotated target: immunoglobulin A heavy chain
has db xref: PRO:DAN

Axiom
annotated source: IgA heavy chain protein
annotated property: hasExactSynonym
annotated target: immunoglobulin alpha heavy chain
has db xref: PRO:DAN

Axiom
annotated source: IgA heavy chain protein
annotated property: hasExactSynonym
annotated target: immunoglobulin heavy chain alpha
has db xref: PRO:DAN

IgA1 heavy chain protein
type: Class
subclass of: IgA heavy chain protein
IAO_0000115: An IgA heavy chain protein in which the constant region is encoded by the IgA1 gene segment.
has exact synonym: IgHA1
has exact synonym: immunoglobulin A1 heavy chain
has exact synonym: immunoglobulin alpha 1 heavy chain
has exact synonym: immunoglobulin heavy chain alpha 1
has OBO namespace: protein
id: PR:000050177
comment: Category=gene. Requested by=IEDB.

Axiom
annotated source: IgA1 heavy chain protein
annotated property: IAO_0000115
annotated target: An IgA heavy chain protein in which the constant region is encoded by the IgA1 gene segment.
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein
annotated property: hasExactSynonym
annotated target: IgHA1
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: IgA1 heavy chain protein
annotated property: hasExactSynonym
annotated target: immunoglobulin A1 heavy chain
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein
annotated property: hasExactSynonym
annotated target: immunoglobulin alpha 1 heavy chain
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein
annotated property: hasExactSynonym
annotated target: immunoglobulin heavy chain alpha 1
has db xref: PRO:DAN

IgA1 heavy chain protein (human)
type: Class
equivalent class: Class
  intersection of: IgA1 heavy chain protein
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
IAO_0000115: An IgA1 heavy chain protein that is encoded in the genome of human.
has exact synonym: hIgHA1
has exact synonym: immunoglobulin A1 heavy chain (human)
has exact synonym: immunoglobulin alpha 1 heavy chain (human)
has exact synonym: immunoglobulin heavy chain alpha 1 (human)
has OBO namespace: protein
id: PR:000050179
comment: Category=organism-gene.

Axiom
annotated source: IgA1 heavy chain protein (human)
annotated property: IAO_0000115
annotated target: An IgA1 heavy chain protein that is encoded in the genome of human.
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein (human)
annotated property: hasExactSynonym
annotated target: hIgHA1
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: IgA1 heavy chain protein (human)
annotated property: hasExactSynonym
annotated target: immunoglobulin A1 heavy chain (human)
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein (human)
annotated property: hasExactSynonym
annotated target: immunoglobulin alpha 1 heavy chain (human)
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein (human)
annotated property: hasExactSynonym
annotated target: immunoglobulin heavy chain alpha 1 (human)
has db xref: PRO:DAN

Ig kappa light chain protein
type: Class
subclass of: immunoglobulin light chain protein
IAO_0000115: An immunoglobulin light chain protein that is produced from the immunoglobulin kappa locus.
has exact synonym: IgKappa
has OBO namespace: protein
id: PR:000050181
comment: Category=gene. Note: In human, the kappa light chain locus is described by https://www.genenames.org/cgi-bin/genefamilies/set/351. In mouse, the kappa locus is described by MGI:96494.

Axiom
annotated source: Ig kappa light chain protein
annotated property: IAO_0000115
annotated target: An immunoglobulin light chain protein that is produced from the immunoglobulin kappa locus.
has db xref: PRO:DAN

Axiom
annotated source: Ig kappa light chain protein
annotated property: hasExactSynonym
annotated target: IgKappa
has db xref: PRO:DAN
has synonym type: PRO-short-label

Ig lambda light chain protein
type: Class
subclass of: immunoglobulin light chain protein
IAO_0000115: An immunoglobulin light chain protein that is produced from the immunoglobulin lambda locus.
has exact synonym: IgLambda
has OBO namespace: protein
id: PR:000050182
comment: Category=gene. Note: In human, the lambda light chain locus is described by https://www.genenames.org/cgi-bin/genefamilies/set/353. In mouse, the lambda locus is described by MGI:96526.

Axiom
annotated source: Ig lambda light chain protein
annotated property: IAO_0000115
annotated target: An immunoglobulin light chain protein that is produced from the immunoglobulin lambda locus.
has db xref: PRO:DAN

Axiom
annotated source: Ig lambda light chain protein
annotated property: hasExactSynonym
annotated target: IgLambda
has db xref: PRO:DAN
has synonym type: PRO-short-label

immunoglobulin light chain protein (human)
type: Class
equivalent class: Class
  union of: Ig kappa light chain protein (human)
  union of: Ig lambda light chain protein (human)
subclass of: immunoglobulin light chain protein
subclass of: Restriction
  on property: only_in_taxon
  some values from: Homo sapiens
IAO_0000115: An immunoglobulin light chain protein that is encoded in the genome of human.
has exact synonym: hIgL
has OBO namespace: protein
id: PR:000050183
comment: Category=organism-family. Note: The kappa light chain locus is described by https://www.genenames.org/cgi-bin/genefamilies/set/351, and the lambda light chain locus is described by https://www.genenames.org/cgi-bin/genefamilies/set/353.

Axiom
annotated source: immunoglobulin light chain protein (human)
annotated property: IAO_0000115
annotated target: An immunoglobulin light chain protein that is encoded in the genome of human.
has db xref: PRO:DAN

Axiom
annotated source: immunoglobulin light chain protein (human)
annotated property: hasExactSynonym
annotated target: hIgL
has db xref: PRO:DAN
has synonym type: PRO-short-label

Ig kappa light chain protein (human)
type: Class
equivalent class: Class
  intersection of: Ig kappa light chain protein
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
IAO_0000115: An Ig kappa light chain protein that is encoded in the genome of human.
has exact synonym: hIgKappa
has OBO namespace: protein
id: PR:000050184
comment: Category=organism-gene. Note: The kappa light chain locus is described by https://www.genenames.org/cgi-bin/genefamilies/set/351.

Axiom
annotated source: Ig kappa light chain protein (human)
annotated property: IAO_0000115
annotated target: An Ig kappa light chain protein that is encoded in the genome of human.
has db xref: PRO:DAN

Axiom
annotated source: Ig kappa light chain protein (human)
annotated property: hasExactSynonym
annotated target: hIgKappa
has db xref: PRO:DAN
has synonym type: PRO-short-label

Ig lambda light chain protein (human)
type: Class
equivalent class: Class
  intersection of: Ig lambda light chain protein
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
IAO_0000115: An Ig lambda light chain protein that is encoded in the genome of human.
has exact synonym: hIgLambda
has OBO namespace: protein
id: PR:000050185
comment: Category=organism-gene. Note: The lambda light chain locus is described by https://www.genenames.org/cgi-bin/genefamilies/set/353.

Axiom
annotated source: Ig lambda light chain protein (human)
annotated property: IAO_0000115
annotated target: An Ig lambda light chain protein that is encoded in the genome of human.
has db xref: PRO:DAN

Axiom
annotated source: Ig lambda light chain protein (human)
annotated property: hasExactSynonym
annotated target: hIgLambda
has db xref: PRO:DAN
has synonym type: PRO-short-label

polymeric immunoglobulin receptor secretory component
type: Class
subclass of: polymeric immunoglobulin receptor, signal peptide removed form
subclass of: Restriction
  on property: output_of
  some values from: protein processing
IAO_0000115: A polymeric immunoglobulin receptor, signal peptide removed form that has been processed by proteolytic cleavage to separate the extracellular domain (represented here) from the transmembrane domain. Example: UniProtKB:P01833, 19-603.
has exact synonym: PIGR/SC
has exact synonym: SC
has exact synonym: secretory component
has OBO namespace: protein
id: PR:000050188
comment: Category=modification. Requested by=HIPC. Requested by=CL.

Axiom
annotated source: polymeric immunoglobulin receptor secretory component
annotated property: IAO_0000115
annotated target: A polymeric immunoglobulin receptor, signal peptide removed form that has been processed by proteolytic cleavage to separate the extracellular domain (represented here) from the transmembrane domain. Example: UniProtKB:P01833, 19-603.
has db xref: GOC:add
has db xref: ISBN:0781765196
has db xref: PMID:16362985
has db xref: PRO:ADD
has db xref: PRO:DAN

Axiom
annotated source: polymeric immunoglobulin receptor secretory component
annotated property: hasExactSynonym
annotated target: PIGR/SC
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: polymeric immunoglobulin receptor secretory component
annotated property: hasExactSynonym
annotated target: SC
has db xref: GOC:add
has db xref: PRO:ADD

Axiom
annotated source: polymeric immunoglobulin receptor secretory component
annotated property: hasExactSynonym
annotated target: secretory component
has db xref: GOC:add
has db xref: PRO:ADD

IgA1 heavy chain protein, secretory isoform
type: Class
subclass of: IgA1 heavy chain protein
IAO_0000115: An IgA1 heavy chain protein that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA.
has exact synonym: IgHA1/iso:secretory
has exact synonym: immunoglobulin A1 heavy chain, secretory isoform
has exact synonym: immunoglobulin alpha 1 heavy chain, secretory isoform
has exact synonym: immunoglobulin heavy chain alpha 1, secretory isoform
has OBO namespace: protein
id: PR:000050372
comment: Category=seqgroup. Requested by=HIPC. Requested by=CL.

Axiom
annotated source: IgA1 heavy chain protein, secretory isoform
annotated property: IAO_0000115
annotated target: An IgA1 heavy chain protein that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA.
has db xref: GOC:add
has db xref: PRO:ADD
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein, secretory isoform
annotated property: hasExactSynonym
annotated target: IgHA1/iso:secretory
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: IgA1 heavy chain protein, secretory isoform
annotated property: hasExactSynonym
annotated target: immunoglobulin A1 heavy chain, secretory isoform
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein, secretory isoform
annotated property: hasExactSynonym
annotated target: immunoglobulin alpha 1 heavy chain, secretory isoform
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein, secretory isoform
annotated property: hasExactSynonym
annotated target: immunoglobulin heavy chain alpha 1, secretory isoform
has db xref: PRO:DAN

IgA1 heavy chain protein, secretory isoform (human)
type: Class
equivalent class: Class
  intersection of: IgA1 heavy chain protein, secretory isoform
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
IAO_0000115: An IgA1 heavy chain protein, secretory isoform that is encoded in the genome of human. This is a translation product of an IgA1 mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA.
has exact synonym: hIgHA1/iso:secretory
has exact synonym: immunoglobulin A1 heavy chain, secretory isoform (human)
has exact synonym: immunoglobulin alpha 1 heavy chain, secretory isoform (human)
has exact synonym: immunoglobulin heavy chain alpha 1, secretory isoform (human)
has OBO namespace: protein
id: PR:000050376
comment: Category=organism-seqgroup. Requested by=HIPC. Requested by=CL.

Axiom
annotated source: IgA1 heavy chain protein, secretory isoform (human)
annotated property: IAO_0000115
annotated target: An IgA1 heavy chain protein, secretory isoform that is encoded in the genome of human. This is a translation product of an IgA1 mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA.
has db xref: GOC:add
has db xref: PRO:ADD
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein, secretory isoform (human)
annotated property: hasExactSynonym
annotated target: hIgHA1/iso:secretory
has db xref: PRO:DAN
has synonym type: PRO-short-label

Axiom
annotated source: IgA1 heavy chain protein, secretory isoform (human)
annotated property: hasExactSynonym
annotated target: immunoglobulin A1 heavy chain, secretory isoform (human)
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein, secretory isoform (human)
annotated property: hasExactSynonym
annotated target: immunoglobulin alpha 1 heavy chain, secretory isoform (human)
has db xref: PRO:DAN

Axiom
annotated source: IgA1 heavy chain protein, secretory isoform (human)
annotated property: hasExactSynonym
annotated target: immunoglobulin heavy chain alpha 1, secretory isoform (human)
has db xref: PRO:DAN

immunoglobulin J chain (human)
type: Class
equivalent class: Class
  intersection of: immunoglobulin J chain
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
subclass of: Restriction
  on property: has_gene_template
  some values from: JCHAIN (human)
IAO_0000115: An immunoglobulin J chain that is encoded in the genome of human.
has db xref: UniProtKB:P01591
has exact synonym: hJCHAIN
has exact synonym: joining chain of multimeric IgA and IgM (human)
has OBO namespace: protein
has related synonym: IGCJ
has related synonym: IGJ
has related synonym: JCHAIN
id: PR:P01591
comment: Category=organism-gene.

Axiom
annotated source: immunoglobulin J chain (human)
annotated property: IAO_0000115
annotated target: An immunoglobulin J chain that is encoded in the genome of human.
has db xref: PRO:DNx
has db xref: UniProtKB:P01591

Axiom
annotated source: immunoglobulin J chain (human)
annotated property: hasExactSynonym
annotated target: hJCHAIN
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: immunoglobulin J chain (human)
annotated property: hasExactSynonym
annotated target: joining chain of multimeric IgA and IgM (human)
has db xref: UniProtKB:P01591

Axiom
annotated source: immunoglobulin J chain (human)
annotated property: hasRelatedSynonym
annotated target: IGCJ
has db xref: UniProtKB:P01591
has synonym type: Gene-based

Axiom
annotated source: immunoglobulin J chain (human)
annotated property: hasRelatedSynonym
annotated target: IGJ
has db xref: UniProtKB:P01591
has synonym type: Gene-based

Axiom
annotated source: immunoglobulin J chain (human)
annotated property: hasRelatedSynonym
annotated target: JCHAIN
has db xref: UniProtKB:P01591
has synonym type: Gene-based

polymeric immunoglobulin receptor (human)
type: Class
equivalent class: Class
  intersection of: polymeric immunoglobulin receptor
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
subclass of: Restriction
  on property: has_gene_template
  some values from: PIGR (human)
IAO_0000115: A polymeric immunoglobulin receptor that is encoded in the genome of human.
has db xref: UniProtKB:P01833
has exact synonym: PIgR (human)
has exact synonym: hPIGR
has exact synonym: hepatocellular carcinoma-associated protein TB6 (human)
has exact synonym: poly-Ig receptor (human)
has OBO namespace: protein
has related synonym: PIGR
id: PR:P01833
comment: Category=organism-gene.

Axiom
annotated source: polymeric immunoglobulin receptor (human)
annotated property: IAO_0000115
annotated target: A polymeric immunoglobulin receptor that is encoded in the genome of human.
has db xref: PRO:DNx
has db xref: UniProtKB:P01833

Axiom
annotated source: polymeric immunoglobulin receptor (human)
annotated property: hasExactSynonym
annotated target: PIgR (human)
has db xref: UniProtKB:P01833

Axiom
annotated source: polymeric immunoglobulin receptor (human)
annotated property: hasExactSynonym
annotated target: hPIGR
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: polymeric immunoglobulin receptor (human)
annotated property: hasExactSynonym
annotated target: hepatocellular carcinoma-associated protein TB6 (human)
has db xref: UniProtKB:P01833

Axiom
annotated source: polymeric immunoglobulin receptor (human)
annotated property: hasExactSynonym
annotated target: poly-Ig receptor (human)
has db xref: UniProtKB:P01833

Axiom
annotated source: polymeric immunoglobulin receptor (human)
annotated property: hasRelatedSynonym
annotated target: PIGR
has db xref: UniProtKB:P01833
has synonym type: Gene-based

osteocalcin (human)
type: Class
equivalent class: Class
  intersection of: osteocalcin
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
subclass of: Restriction
  on property: has_gene_template
  some values from: BGLAP (human)
IAO_0000115: An osteocalcin that is encoded in the genome of human.
has db xref: UniProtKB:P02818
has exact synonym: BGP (human)
has exact synonym: bone Gla protein (human)
has exact synonym: gamma-carboxyglutamic acid-containing protein (human)
has exact synonym: hBGLAP
has OBO namespace: protein
has related synonym: BGLAP
id: PR:P02818
comment: Category=organism-gene.

Axiom
annotated source: osteocalcin (human)
annotated property: IAO_0000115
annotated target: An osteocalcin that is encoded in the genome of human.
has db xref: PRO:DNx
has db xref: UniProtKB:P02818

Axiom
annotated source: osteocalcin (human)
annotated property: hasExactSynonym
annotated target: BGP (human)
has db xref: UniProtKB:P02818

Axiom
annotated source: osteocalcin (human)
annotated property: hasExactSynonym
annotated target: bone Gla protein (human)
has db xref: UniProtKB:P02818

Axiom
annotated source: osteocalcin (human)
annotated property: hasExactSynonym
annotated target: gamma-carboxyglutamic acid-containing protein (human)
has db xref: UniProtKB:P02818

Axiom
annotated source: osteocalcin (human)
annotated property: hasExactSynonym
annotated target: hBGLAP
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: osteocalcin (human)
annotated property: hasRelatedSynonym
annotated target: BGLAP
has db xref: UniProtKB:P02818
has synonym type: Gene-based

T-cell-specific surface glycoprotein CD28 (human)
type: Class
equivalent class: Class
  intersection of: T-cell-specific surface glycoprotein CD28
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
subclass of: Restriction
  on property: has_gene_template
  some values from: CD28 (human)
IAO_0000115: A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of human.
has db xref: UniProtKB:P10747
has exact synonym: TP44 (human)
has exact synonym: hCD28
has OBO namespace: protein
has related synonym: CD28
id: PR:P10747
comment: Category=organism-gene.

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 (human)
annotated property: IAO_0000115
annotated target: A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of human.
has db xref: PRO:WCB
has db xref: UniProtKB:P10747

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 (human)
annotated property: hasExactSynonym
annotated target: TP44 (human)
has db xref: UniProtKB:P10747

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 (human)
annotated property: hasExactSynonym
annotated target: hCD28
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 (human)
annotated property: hasRelatedSynonym
annotated target: CD28
has db xref: UniProtKB:P10747
has synonym type: Gene-based

T-cell-specific surface glycoprotein CD28 isoform 1 (human)
type: Class
equivalent class: Class
  intersection of: T-cell-specific surface glycoprotein CD28 isoform 1
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
IAO_0000115: A T-cell-specific surface glycoprotein CD28 isoform 1 that is encoded in the genome of human.
has db xref: UniProtKB:P10747-1
has exact synonym: hCD28/iso:1
has OBO namespace: protein
id: PR:P10747-1
comment: Category=organism-sequence.

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1 (human)
annotated property: IAO_0000115
annotated target: A T-cell-specific surface glycoprotein CD28 isoform 1 that is encoded in the genome of human.
has db xref: PRO:CNA

Axiom
annotated source: T-cell-specific surface glycoprotein CD28 isoform 1 (human)
annotated property: hasExactSynonym
annotated target: hCD28/iso:1
has db xref: PRO:DNx
has synonym type: PRO-short-label

collagen alpha-1(V) chain (human)
type: Class
equivalent class: Class
  intersection of: collagen alpha-1(V) chain
  intersection of: Restriction
    on property: only_in_taxon
    some values from: Homo sapiens
subclass of: Restriction
  on property: has_gene_template
  some values from: COL5A1 (human)
IAO_0000115: A collagen alpha-1(V) chain that is encoded in the genome of human.
has db xref: Reactome:R-HSA-2268801
has db xref: UniProtKB:P20908
has exact synonym: hCOL5A1
has OBO namespace: protein
has related synonym: COL5A1
id: PR:P20908
comment: Category=organism-gene.

Axiom
annotated source: collagen alpha-1(V) chain (human)
annotated property: IAO_0000115
annotated target: A collagen alpha-1(V) chain that is encoded in the genome of human.
has db xref: PRO:CNA
has db xref: UniProtKB:P20908

PR:P20908 located_in GO:0005576
type: Axiom
annotated source: collagen alpha-1(V) chain (human)
annotated property: hasDbXref
annotated target: Reactome:R-HSA-2268801

Axiom
annotated source: collagen alpha-1(V) chain (human)
annotated property: hasExactSynonym
annotated target: hCOL5A1
has db xref: PRO:DNx
has synonym type: PRO-short-label

Axiom
annotated source: collagen alpha-1(V) chain (human)
annotated property: hasRelatedSynonym
annotated target: COL5A1
has db xref: UniProtKB:P20908
has synonym type: Gene-based

protein_coding
type: Class
subclass of: quality
has exact synonym: protein-coding
has OBO namespace: sequence
id: SO:0000010

sequence_feature
type: Class
IAO_0000115: An extent of biological sequence.
has exact synonym: located_sequence_feature
has exact synonym: sequence feature
has OBO namespace: sequence
has related synonym: located sequence feature
id: SO:0000110

Axiom
annotated source: sequence_feature
annotated property: IAO_0000115
annotated target: An extent of biological sequence.
has db xref: SO:ke

signal_peptide
type: Class
subclass of: immature protein part
has exact synonym: signal peptide
has OBO namespace: sequence
has related synonym: signal
id: SO:0000418
comment: The signal peptide can be cleaved either co- or post-translationally. For this reason, we do not use the derives_from relation when defining protein forms lacking the signal peptide (because the precursor form might not yet exist at the time of removal).

Axiom
annotated source: signal_peptide
annotated property: hasRelatedSynonym
annotated target: signal
has db xref: uniprot:feature_type

gene
type: Class
subclass of: sequence_feature
IAO_0000115: A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions.
has OBO namespace: sequence
id: SO:0000704

Axiom
annotated source: gene
annotated property: IAO_0000115
annotated target: A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions.
has db xref: SO:immuno_workshop

propeptide
type: Class
subclass of: immature protein part
has OBO namespace: sequence
id: SO:0001062

protein_coding_gene
type: Class
subclass of: gene
subclass of: Restriction
  on property: has_quality
  some values from: protein_coding
has exact synonym: protein coding gene
has OBO namespace: sequence
id: SO:0001217