Ontology for Biomarkers of Clinical Interest
type: Ontology
version info: 2024-10-18
version IRI: obci.owl
imports: obci external assertions.obo
imports: obci import bcidb.owl
imports: obci import gene.owl
imports: obci import dbSNP.owl
imports: obci import chebi.owl
imports: obci import cido.owl
imports: obci import cl.owl
imports: obci import doid.owl
imports: obci import ecto.owl
imports: obci import gno.owl
imports: obci import go.owl
imports: obci import iao.owl
imports: obci import ncbitaxon.owl
imports: obci import ncit.owl
imports: obci import pato.owl
imports: obci import pr.owl
imports: obci import ro.owl
imports: obci import so.owl
imports: obci import uberon.owl
description: The Ontology for Biomarkers of Clinical Interest (OBCI) formally defines biomarkers for diseases, phenotypes, and effects.
license: http://creativecommons.org/licenses/by/4.0/
default-namespace: biomarker
saved-by: https://github.com/nataled
comment: The Ontology for Biomarkers of Clinical Interest is licensed under CC BY 4.0. Please see http://obofoundry.org/ontology/obci for details.
comment: Use the Hermit reasoner in Protege to see the correct hierarchy.

definition
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_synonym_type
type: AnnotationProperty

shorthand
type: AnnotationProperty

provides_clinical_information_for
type: ObjectProperty
sub property of: RO_0002607
definition: A relationship between a biomarker 'c' and a disease or condition of clinical interest 'd', where the presence or occurrence of 'c' provides clinical information about 'd'.
IAO_0000116: This does not imply that 'c' and 'd' are in a direct causal relationship, as it may be the case that there is a third entity 'e' that stands in a direct causal relationship with 'c' and 'd'.
database_cross_reference: OBCI:100000001
has_obo_namespace: biomarker
id: provides_clinical_information_for
shorthand: provides_clinical_information_for
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: provides_clinical_information_for
annotated property: definition
annotated target: A relationship between a biomarker 'c' and a disease or condition of clinical interest 'd', where the presence or occurrence of 'c' provides clinical information about 'd'.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

diagnostic_for
type: ObjectProperty
range: Class
  union of: DOID 4
  union of: NCIT C156809
sub property of: provides_clinical_information_for
definition: A relationship between a biomarker 'c' and a disease or condition of clinical interest 'd', where the presence or occurrence of 'c' is used to infer the presence or occurrence of 'd' or determine its subtype.
database_cross_reference: OBCI:100000002
has_obo_namespace: biomarker
id: diagnostic_for
shorthand: diagnostic_for
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: diagnostic_for
annotated property: definition
annotated target: A relationship between a biomarker 'c' and a disease or condition of clinical interest 'd', where the presence or occurrence of 'c' is used to infer the presence or occurrence of 'd' or determine its subtype.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

monitors_status_of
type: ObjectProperty
range: Class
  union of: DOID 4
  union of: NCIT C156809
sub property of: provides_clinical_information_for
definition: A relationship between a serially-measured biomarker 'c' and a disease or condition of clinical interest 'd' or exposure agent 'e', where 'c' is used to infer the status of 'd' or provide evidence of exposure to (or effect of) 'e'.
database_cross_reference: OBCI:100000003
has_obo_namespace: biomarker
id: monitors_status_of
shorthand: monitors_status_of
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: monitors_status_of
annotated property: definition
annotated target: A relationship between a serially-measured biomarker 'c' and a disease or condition of clinical interest 'd' or exposure agent 'e', where 'c' is used to infer the status of 'd' or provide evidence of exposure to (or effect of) 'e'.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

indicates_response_to
type: ObjectProperty
range: ExO_0000002
sub property of: indicates_clinical_effect_of
definition: A relationship between a biomarker 'c' and an exposure agent 'e', where 'c' is used to show that a biological response to 'e' has occurred.
database_cross_reference: OBCI:100000004
has_obo_namespace: biomarker
id: indicates_response_to
shorthand: indicates_response_to
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: indicates_response_to
annotated property: definition
annotated target: A relationship between a biomarker 'c' and an exposure agent 'e', where 'c' is used to show that a biological response to 'e' has occurred.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

predicts_effect_of
type: ObjectProperty
range: ExO_0000002
sub property of: indicates_clinical_effect_of
definition: A relationship between a biomarker 'c' and an exposure agent 'e', where 'c' is used to identify individuals who are likely to experience a favorable or unfavorable effect from exposure to 'e'.
database_cross_reference: OBCI:100000005
has_obo_namespace: biomarker
id: predicts_effect_of
shorthand: predicts_effect_of
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: predicts_effect_of
annotated property: definition
annotated target: A relationship between a biomarker 'c' and an exposure agent 'e', where 'c' is used to identify individuals who are likely to experience a favorable or unfavorable effect from exposure to 'e'.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

prognostic_for
type: ObjectProperty
range: Class
  union of: DOID 4
  union of: NCIT C156809
sub property of: provides_clinical_information_for
definition: A relationship between a biomarker 'c' and a disease or condition of clinical interest 'd', where the presence or occurrence of 'c' is used to infer the likelihood of a clinical event, disease recurrence or progression in patients who have 'd'.
database_cross_reference: OBCI:100000006
has_obo_namespace: biomarker
id: prognostic_for
shorthand: prognostic_for
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: prognostic_for
annotated property: definition
annotated target: A relationship between a biomarker 'c' and a disease or condition of clinical interest 'd', where the presence or occurrence of 'c' is used to infer the likelihood of a clinical event, disease recurrence or progression in patients who have 'd'.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

assesses_toxicity_of
type: ObjectProperty
range: ExO_0000002
sub property of: indicates_clinical_effect_of
definition: A relationship between a biomarker 'c' and an exposure agent 'e', where 'c' is used to indicate the likelihood, presence, or extent of toxicity as an adverse effect of exposure to 'e'.
database_cross_reference: OBCI:100000007
has_obo_namespace: biomarker
id: assesses_toxicity_of
shorthand: assesses_toxicity_of
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: assesses_toxicity_of
annotated property: definition
annotated target: A relationship between a biomarker 'c' and an exposure agent 'e', where 'c' is used to indicate the likelihood, presence, or extent of toxicity as an adverse effect of exposure to 'e'.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

indicates_risk_of_developing
type: ObjectProperty
range: Class
  union of: DOID 4
  union of: NCIT C156809
sub property of: provides_clinical_information_for
database_cross_reference: OBCI:100000008
has_exact_synonym: indicates_susceptibility_to
has_obo_namespace: biomarker
id: indicates_risk_of_developing
shorthand: indicates_risk_of_developing
created by: https://orcid.org/0000-0001-5809-9523

indicated_by_above_normal_level_of
type: ObjectProperty
sub property of: indicated_by_difference_in_level_of
IAO_0000116: 'Level' here can refer to raw counts, percentages, ratios, concentrations, activities, etc.
database_cross_reference: OBCI:100000009
has_obo_namespace: biomarker
id: indicated_by_above_normal_level_of
shorthand: indicated_by_above_normal_level_of
created by: https://orcid.org/0000-0001-5809-9523

indicates_clinical_effect_of
type: ObjectProperty
sub property of: RO_0002607
definition: A relationship between a biomarker 'c' and an exposure agent 'd', where the effect of exposure to 'd' is correlated with the presence or occurrence of 'c', and the observation of 'c' is used to infer exposure to 'd'.
IAO_0000116: This does not imply that 'c' and 'd' are in a direct causal relationship, as it may be the case that there is a third entity 'e' that stands in a direct causal relationship with 'c' and 'd'.
database_cross_reference: OBCI:100000010
has_obo_namespace: biomarker
id: indicates_clinical_effect_of
shorthand: indicates_clinical_effect_of
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: indicates_clinical_effect_of
annotated property: definition
annotated target: A relationship between a biomarker 'c' and an exposure agent 'd', where the effect of exposure to 'd' is correlated with the presence or occurrence of 'c', and the observation of 'c' is used to infer exposure to 'd'.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

has_BEST_classification
type: ObjectProperty
definition: A relationship between a biomarker 'c' and its purpose as defined by the BEST classification system.
database_cross_reference: OBCI:100000011
has_obo_namespace: biomarker
id: has_BEST_classification
shorthand: has_BEST_classification
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: has_BEST_classification
annotated property: definition
annotated target: A relationship between a biomarker 'c' and its purpose as defined by the BEST classification system.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

has_CIViC_classification
type: ObjectProperty
definition: A relationship between a biomarker 'c' and its evidence type as defined by the CIViC classification system.
database_cross_reference: OBCI:100000012
has_obo_namespace: biomarker
id: has_CIViC_classification
shorthand: has_CIViC_classification
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: has_CIViC_classification
annotated property: definition
annotated target: A relationship between a biomarker 'c' and its evidence type as defined by the CIViC classification system.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

monitors_effect_of
type: ObjectProperty
range: ExO_0000002
sub property of: indicates_clinical_effect_of
database_cross_reference: OBCI:100000013
has_obo_namespace: biomarker
id: monitors_effect_of
shorthand: monitors_effect_of
created by: https://orcid.org/0000-0001-5809-9523

indicated_by_difference_in_level_of
type: ObjectProperty
IAO_0000116: 'Level' here can refer to raw counts, percentages, ratios, concentrations, etc.
database_cross_reference: OBCI:100000014
has_obo_namespace: biomarker
id: indicated_by_difference_in_level_of
shorthand: indicated_by_difference_in_level_of
created by: https://orcid.org/0000-0001-5809-9523

indicated_by_below_normal_level_of
type: ObjectProperty
sub property of: indicated_by_difference_in_level_of
IAO_0000116: 'Level' here can refer to raw counts, percentages, ratios, concentrations, etc.
database_cross_reference: OBCI:100000015
has_obo_namespace: biomarker
id: indicated_by_below_normal_level_of
shorthand: indicated_by_below_normal_level_of
created by: https://orcid.org/0000-0001-5809-9523

indicated_by_presence_of
type: ObjectProperty
sub property of: indicated_by_difference_in_level_of
id: indicated_by_presence_of
created by: https://orcid.org/0000-0001-5809-9523

indicated_by_absence_of
type: ObjectProperty
sub property of: indicated_by_difference_in_level_of
id: indicated_by_absence_of
created by: https://orcid.org/0000-0001-5809-9523

determined_using_sample_from
type: ObjectProperty
database_cross_reference: OBCI:100000018
id: determined_using_sample_from
shorthand: determined_using_sample_from
created by: https://orcid.org/0000-0001-5809-9523

biomarker
type: Class
definition: A defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or biological responses to an exposure or intervention, including therapeutic interventions.
IAO_0000116: We make a distinction between 'biomarker' and 'biomarker assessed entity'. The former derives from result of measurement or observation of the latter. For example, in and of itself, 'blood sugar' is not considered a biomarker in our treatment, but 'elevated blood sugar' is. Another example is BRCA1; despite appearing on lists of cancer-implicated genes, BRCA1 is _not_ a biomarker of cancer in our treatment. However, the presence of a particular allele of BRCA1 can be a biomarker, or BRCA1 over-expression can be a biomarker.
IAO_0000116: Biomarkers require comparison between characteristics of interest obtained in test cases vs those in normal cases. What is considered 'normal' will depend on the biomarker; in some cases the comparison will be to a population average, in others it will be to an individual's known healthy state.
has_obo_namespace: biomarker
comment: Molecular, histologic, radiographic, or physiologic characteristics are types of biomarkers. A biomarker is not an assessment of how an individual feels, functions, or survives.
id: OBCI:000000001
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker
annotated property: definition
annotated target: A defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or biological responses to an exposure or intervention, including therapeutic interventions.
database_cross_reference: FDA-NIH Biomarker Working Group

Axiom
annotated source: biomarker
annotated property: comment
annotated target: Molecular, histologic, radiographic, or physiologic characteristics are types of biomarkers. A biomarker is not an assessment of how an individual feels, functions, or survives.
comment: FDA-NIH Biomarker Working Group

diagnostic biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Class
    union of: Restriction
      on property: diagnostic_for
      some values from: Class
        union of: DOID 4
        union of: NCIT C156809
    union of: Restriction
      on property: has_BEST_classification
      has value: diagnostic (BEST)
    union of: Restriction
      on property: has_CIViC_classification
      has value: diagnostic (CIViC)
subclass of: biomarker with specified BEST category
definition: A biomarker that is used to detect or confirm the presence of a disease or condition of interest or to identify individuals with a subtype of the disease.
has_exact_synonym: diagnostic evidence type
has_obo_namespace: biomarker
id: OBCI:000000002
comment: For a perfect diagnostic biomarker test, all patients with the disease or disease subset would be detected (100% sensitivity, i.e., the fraction of people with disease who test positive) and no patients without the disease would be diagnosed with the disease (100% specificity, i.e., the fraction of people without the disease who test negative). In practice no biomarker test has perfect clinical and analytical sensitivity and specificity. [NCBI:books/NBK402285]
comment: Per CIVic, such biomarkers can help a clinician diagnose or exclude a particular disease.
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: diagnostic biomarker
annotated property: definition
annotated target: A biomarker that is used to detect or confirm the presence of a disease or condition of interest or to identify individuals with a subtype of the disease.
database_cross_reference: FDA-NIH Biomarker Working Group
database_cross_reference: NCBI:books/NBK402285

Axiom
annotated source: diagnostic biomarker
annotated property: has_exact_synonym
annotated target: diagnostic evidence type
database_cross_reference: PMID:31796060

monitoring biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: has_BEST_classification
    has value: monitoring (BEST)
subclass of: biomarker with specified BEST category
definition: A biomarker that is measured serially to assess the status of a disease or medical condition, or for evidence of exposure to (or effect of) a medical product or an environmental agent.
has_obo_namespace: biomarker
id: OBCI:000000003
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: monitoring biomarker
annotated property: definition
annotated target: A biomarker that is measured serially to assess the status of a disease or medical condition, or for evidence of exposure to (or effect of) a medical product or an environmental agent.
database_cross_reference: FDA-NIH Biomarker Working Group
database_cross_reference: NCBI:books/NBK402282

pharmacodynamic/response biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Class
    union of: Restriction
      on property: indicates_response_to
      some values from: ExO_0000002
    union of: Restriction
      on property: has_BEST_classification
      has value: pharmacodynamic/response (BEST)
subclass of: biomarker with specified BEST category
definition: A biomarker that is used to show that a biological response has occurred in an individual who has been exposed to a medical product or an environmental agent.
has_obo_namespace: biomarker
id: OBCI:000000004
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: pharmacodynamic/response biomarker
annotated property: definition
annotated target: A biomarker that is used to show that a biological response has occurred in an individual who has been exposed to a medical product or an environmental agent.
database_cross_reference: FDA-NIH Biomarker Working Group
database_cross_reference: NCBI:books/NBK402286

predictive biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Class
    union of: Restriction
      on property: predicts_effect_of
      some values from: ExO_0000002
    union of: Restriction
      on property: has_BEST_classification
      has value: predictive (BEST)
    union of: Restriction
      on property: has_CIViC_classification
      has value: predictive (CIViC)
subclass of: biomarker with specified BEST category
definition: A biomarker that is used to identify individuals who are more likely than similar individuals without the biomarker to experience a favorable or unfavorable effect from exposure to a medical product or an environmental agent.
has_exact_synonym: predictive evidence type
has_obo_namespace: biomarker
id: OBCI:000000005
comment: Per CIVic, such biomarkers help predict drug sensitivity or therapeutic response and are valuable in deciding further treatments. Predictive evidence items often explain mechanisms of drug resistance.
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: predictive biomarker
annotated property: definition
annotated target: A biomarker that is used to identify individuals who are more likely than similar individuals without the biomarker to experience a favorable or unfavorable effect from exposure to a medical product or an environmental agent.
database_cross_reference: FDA-NIH Biomarker Working Group
database_cross_reference: NCBI:books/NBK402283

Axiom
annotated source: predictive biomarker
annotated property: has_exact_synonym
annotated target: predictive evidence type
database_cross_reference: PMID:31796060

prognostic biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Class
    union of: Restriction
      on property: prognostic_for
      some values from: Class
        union of: DOID 4
        union of: NCIT C156809
    union of: Restriction
      on property: has_BEST_classification
      has value: prognostic (BEST)
    union of: Restriction
      on property: has_CIViC_classification
      has value: prognostic (CIViC)
subclass of: biomarker with specified BEST category
definition: A biomarker that is used to identify the likelihood of a clinical event, disease recurrence or progression in patients who have the disease or medical condition of interest.
has_exact_synonym: prognostic evidence type
has_obo_namespace: biomarker
id: OBCI:000000006
comment: Per CIVic, such biomarkers are those that predict survival outcome.
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: prognostic biomarker
annotated property: definition
annotated target: A biomarker that is used to identify the likelihood of a clinical event, disease recurrence or progression in patients who have the disease or medical condition of interest.
database_cross_reference: FDA-NIH Biomarker Working Group
database_cross_reference: NCBI:books/NBK402289

Axiom
annotated source: prognostic biomarker
annotated property: has_exact_synonym
annotated target: prognostic evidence type
database_cross_reference: PMID:31796060

safety biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Class
    union of: Restriction
      on property: assesses_toxicity_of
      some values from: ExO_0000002
    union of: Restriction
      on property: has_BEST_classification
      has value: safety (BEST)
subclass of: biomarker with specified BEST category
definition: A biomarker that is used to indicate the likelihood, presence, or extent of toxicity as an adverse effect. Such biomarkers are measured before and after exposure to a medical product or an environmental agent.
has_obo_namespace: biomarker
id: OBCI:000000007
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: safety biomarker
annotated property: definition
annotated target: A biomarker that is used to indicate the likelihood, presence, or extent of toxicity as an adverse effect. Such biomarkers are measured before and after exposure to a medical product or an environmental agent.
database_cross_reference: FDA-NIH Biomarker Working Group
database_cross_reference: NCBI:books/NBK402287

susceptibility/risk biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Class
    union of: Restriction
      on property: indicates_risk_of_developing
      some values from: Class
        union of: DOID 4
        union of: NCIT C156809
    union of: Restriction
      on property: has_BEST_classification
      has value: susceptibility/risk (BEST)
    union of: Restriction
      on property: has_CIViC_classification
      has value: predisposing (CIViC)
subclass of: biomarker with specified BEST category
definition: A biomarker that is used to indicate the potential for developing a disease or medical condition in an individual who does not currently have clinically apparent disease or the medical condition.
has_exact_synonym: predisposing evidence type
has_obo_namespace: biomarker
id: OBCI:000000008
comment: Per CIVic, such biomarkers are those that indicate an increased likelihood of developing a particular disease.
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: susceptibility/risk biomarker
annotated property: definition
annotated target: A biomarker that is used to indicate the potential for developing a disease or medical condition in an individual who does not currently have clinically apparent disease or the medical condition.
database_cross_reference: FDA-NIH Biomarker Working Group
database_cross_reference: NCBI:books/NBK402288

Axiom
annotated source: susceptibility/risk biomarker
annotated property: has_exact_synonym
annotated target: predisposing evidence type
database_cross_reference: PMID:31796060

biomarker of disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 4
definition: A biomarker that provides clinical information about a disease.
has_obo_namespace: biomarker
id: OBCI:000000009
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of disease
annotated property: definition
annotated target: A biomarker that provides clinical information about a disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of COVID-19
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID_0080600
definition: A biomarker that provides clinical information about COVID-19.
has_obo_namespace: biomarker
id: OBCI:000000010
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of COVID-19
annotated property: definition
annotated target: A biomarker that provides clinical information about COVID-19.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of cancer
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 162
definition: A biomarker that provides clinical information about cancer.
has_obo_namespace: biomarker
id: OBCI:000000011
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of cancer
annotated property: definition
annotated target: A biomarker that provides clinical information about cancer.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of exposure
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicates_clinical_effect_of
    some values from: ExO_0000002
definition: A biomarker that indicates the clinical effect of or response to exposure to a substance.
has_obo_namespace: biomarker
id: OBCI:000000012
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of exposure
annotated property: definition
annotated target: A biomarker that indicates the clinical effect of or response to exposure to a substance.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

urine biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0001088
definition: A biomarker that is assessed using urine as the anatomical source.
has_obo_namespace: biomarker
id: OBCI:000000013
created by: https://orcid.org/0000-0001-5809-9523
database_cross_reference: https://orcid.org/0000-0001-5809-9523

blood plasma biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0001969
definition: A biomarker that is assessed using blood plasma as the anatomical source.
has_obo_namespace: biomarker
id: OBCI:000000014
created by: https://orcid.org/0000-0001-5809-9523

biomarker of medical condition
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: Class
      union of: DOID 4
      union of: NCIT C156809
definition: A biomarker that provides clinical information about some current or potential medical condition.
has_obo_namespace: biomarker
id: OBCI:000000015
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of medical condition
annotated property: definition
annotated target: A biomarker that provides clinical information about some current or potential medical condition.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker with specified BEST category
type: Class
equivalent class: Class
  union of: diagnostic biomarker
  union of: monitoring biomarker
  union of: pharmacodynamic/response biomarker
  union of: predictive biomarker
  union of: prognostic biomarker
  union of: safety biomarker
  union of: susceptibility/risk biomarker
subclass of: biomarker
definition: A biomarker that has an indicated BEST category.
has_obo_namespace: biomarker
id: OBCI:000000016
comment: This is a grouping term.
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker with specified BEST category
annotated property: definition
annotated target: A biomarker that has an indicated BEST category.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker with specified assessed entity
type: Class
subclass of: biomarker
definition: A biomarker that has an indicated assessed entity.
has_obo_namespace: biomarker
id: OBCI:000000017
comment: This is a grouping term.
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker with specified assessed entity
annotated property: definition
annotated target: A biomarker that has an indicated assessed entity.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker with specified clinical focus
type: Class
equivalent class: Class
  union of: biomarker of exposure
  union of: biomarker of medical condition
definition: A biomarker that has an indicated clinical focus.
has_obo_namespace: biomarker
id: OBCI:000000018
comment: This is a grouping term.
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker with specified clinical focus
annotated property: definition
annotated target: A biomarker that has an indicated clinical focus.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker with specified anatomical source
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0001062
definition: A biomarker that has an indicated anatomical source.
has_obo_namespace: biomarker
id: OBCI:000000019
comment: This is a grouping term.
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker with specified anatomical source
annotated property: definition
annotated target: A biomarker that has an indicated anatomical source.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

physiological characteristic biomarker
type: Class
subclass of: biomarker with specified assessed entity
definition: A biomarker in which the assessed entity is a physiological characteristic.
IAO_0000116: This class includes cases where the biomarker assesses multiple entities of the same type (for example, by using a panel).
has_obo_namespace: biomarker
id: OBCI:000000020
created by: https://orcid.org/0000-0001-5809-9523

cellular biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_difference_in_level_of
    some values from: CL_0000000
subclass of: biomarker with specified assessed entity
definition: A biomarker in which the assessed entity is a cell.
IAO_0000116: This class includes cases where the biomarker assesses multiple entities of the same type (for example, by using a panel).
has_obo_namespace: biomarker
id: OBCI:000000021
created by: https://orcid.org/0000-0001-5809-9523

genetic variation biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_presence_of
    some values from: SO_0001025
subclass of: molecular biomarker
definition: A biomarker in which the assessed entity is a genetic variation.
comment: Genetic variation can be assessed via direct sequencing of genetic material or can be inferred from protein (for example, by using sequence-specific antibodies).
IAO_0000116: This class includes cases where the biomarker assesses multiple entities of the same type (for example, by using a panel).
has_obo_namespace: biomarker
id: OBCI:000000022
created by: https://orcid.org/0000-0001-5809-9523

glycan biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_difference_in_level_of
    some values from: GNO_00000001
subclass of: molecular biomarker
definition: A biomarker in which the assessed entity is a glycan.
IAO_0000116: This class includes cases where the biomarker assesses multiple entities of the same type (for example, by using a panel).
has_obo_namespace: biomarker
id: OBCI:000000023
created by: https://orcid.org/0000-0001-5809-9523

small molecule biomarker
type: Class
subclass of: molecular biomarker
definition: A biomarker in which the assessed entity is a small molecule.
IAO_0000116: This class includes cases where the biomarker assesses multiple entities of the same type (for example, by using a panel).
has_obo_namespace: biomarker
id: OBCI:000000024
created by: https://orcid.org/0000-0001-5809-9523

RNA biomarker
type: Class
subclass of: molecular biomarker
definition: A biomarker in which the assessed entity is an RNA.
IAO_0000116: This class includes cases where the biomarker assesses multiple entities of the same type (for example, by using a panel).
has_obo_namespace: biomarker
id: OBCI:000000025
created by: https://orcid.org/0000-0001-5809-9523

exhaled breath biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: NCIT C78741
definition: A biomarker that is assessed using exhaled breath as the anatomical source.
has_obo_namespace: biomarker
id: OBCI:000000026
created by: https://orcid.org/0000-0001-5809-9523

propanol in exhaled breath above normal
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_above_normal_level_of
    some values from: CHEBI_28831
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: NCIT C78741
subclass of: small molecule biomarker
definition: A biomarker that is indicated by an above normal level of propanol determined using a sample of exhaled breath.
has_obo_namespace: biomarker
id: OBCI:000000027
created by: https://orcid.org/0000-0001-5809-9523

ethyl butanoate in exhaled breath above normal
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_above_normal_level_of
    some values from: CHEBI_88764
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: NCIT C78741
subclass of: small molecule biomarker
subclass of: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID_0080600
definition: A biomarker that is indicated by an above normal level of ethyl butanoate determined using a sample of exhaled breath.
has_obo_namespace: biomarker
id: OBCI:000000028
created by: https://orcid.org/0000-0001-5809-9523

blood biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0000178
definition: A biomarker that is assessed using blood as the anatomical source.
has_obo_namespace: biomarker
id: OBCI:000000029
created by: https://orcid.org/0000-0001-5809-9523

potassium in blood plasma below normal
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_below_normal_level_of
    some values from: CHEBI_29103
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0001969
subclass of: small molecule biomarker
definition: A biomarker that is indicated by a below normal level of potassium determined using a sample of blood plasma.
has_obo_namespace: biomarker
id: OBCI:000000030
created by: https://orcid.org/0000-0001-5809-9523

sodium in blood below normal
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_below_normal_level_of
    some values from: CHEBI_29101
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0000178
subclass of: small molecule biomarker
definition: A biomarker that is indicated by a below normal level of sodium determined using a sample of blood.
has_obo_namespace: biomarker
id: OBCI:000000031
created by: https://orcid.org/0000-0001-5809-9523

protein biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_difference_in_level_of
    some values from: Class
      union of: GO_0032991
      union of: PR_000000001
subclass of: molecular biomarker
definition: A biomarker in which the assessed entity is a protein-containing molecular entity.
IAO_0000116: This class includes cases where the biomarker assesses multiple entities of the same type (for example, by using a panel).
has_obo_namespace: biomarker
id: OBCI:000000032
created by: https://orcid.org/0000-0001-5809-9523

fibrinogen-to-albumin ratio in blood above normal
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_above_normal_level_of
    some values from: fibrinogen-to-albumin ratio
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0000178
subclass of: protein biomarker
definition: A biomarker that is indicated by an above normal fibrinogen-to-albumin ratio determined using a sample of blood.
has_obo_namespace: biomarker
id: OBCI:000000033
created by: https://orcid.org/0000-0001-5809-9523

molecular biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_difference_in_level_of
    some values from: CHEBI_23367
subclass of: biomarker with specified assessed entity
definition: A biomarker in which the assessed entity is a molecular entity.
IAO_0000116: This class includes cases where the biomarker assesses multiple entities of the same type (for example, by using a panel).
has_obo_namespace: biomarker
id: OBCI:000000034
created by: https://orcid.org/0000-0001-5809-9523

monitoring biomarker - clinical condition
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: monitors_status_of
    some values from: Class
      union of: DOID 4
      union of: NCIT C156809
subclass of: monitoring biomarker
definition: A biomarker that is measured serially to assess the status of a disease or medical condition.
has_obo_namespace: biomarker
id: OBCI:000000035
created by: https://orcid.org/0000-0001-5809-9523

monitoring biomarker - exposure
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: monitors_effect_of
    some values from: ExO_0000002
subclass of: monitoring biomarker
definition: A biomarker that is measured serially to assess exposure to (or effect of) a medical product or an environmental agent.
has_obo_namespace: biomarker
id: OBCI:000000036
created by: https://orcid.org/0000-0001-5809-9523

presence of BRCA1 polymorphism rs567534295
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_presence_of
    some values from: rs567534295
definition: A biomarker that is indicated by the presence of polymorphism rs567534295 in the BRCA1 gene.
has_obo_namespace: biomarker
id: OBCI:000000037
created by: https://orcid.org/0000-0001-5809-9523
subclass of: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicates_risk_of_developing
    some values from: DOID 2394

presence of ANGPT2 polymorphism rs12674822
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_presence_of
    some values from: rs12674822
subclass of: Restriction
  on property: prognostic_for
  some values from: DOID 9256
subclass of: Restriction
  on property: indicates_risk_of_developing
  some values from: DOID 9256
subclass of: Restriction
  on property: indicates_risk_of_developing
  some values from: DOID 1324
subclass of: Restriction
  on property: indicates_risk_of_developing
  some values from: DOID 7148
definition: A biomarker that is indicated by the presence of polymorphism rs12674822 in the ANGPT2 gene.
has_obo_namespace: biomarker
id: OBCI:000000038
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: presence of ANGPT2 polymorphism rs12674822
annotated property: subClassOf
annotated target: Restriction
  on property: prognostic_for
  some values from: DOID 9256
xref: PMID:31929743

Axiom
annotated source: presence of ANGPT2 polymorphism rs12674822
annotated property: subClassOf
annotated target: Restriction
  on property: indicates_risk_of_developing
  some values from: DOID 9256
xref: PMID:31929743

Axiom
annotated source: presence of ANGPT2 polymorphism rs12674822
annotated property: subClassOf
annotated target: Restriction
  on property: indicates_risk_of_developing
  some values from: DOID 1324
xref: PMID:31281470

Axiom
annotated source: presence of ANGPT2 polymorphism rs12674822
annotated property: subClassOf
annotated target: Restriction
  on property: indicates_risk_of_developing
  some values from: DOID 7148
xref: PMID:30745815

cerebrospinal fluid biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0001359
definition: A biomarker that is assessed using cerebrospinal fluid as the anatomical source.
has_obo_namespace: biomarker
id: OBCI:000000039
created by: https://orcid.org/0000-0001-5809-9523

potassium in urine below normal
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_below_normal_level_of
    some values from: CHEBI_29103
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0001088
subclass of: small molecule biomarker
definition: A biomarker that is indicated by a below normal level of potassium determined using a sample of urine.
has_obo_namespace: biomarker
id: OBCI:000000030
created by: https://orcid.org/0000-0001-5809-9523

biomarker of respiratory system disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 1579
definition: A biomarker that provides clinical information about some respiratory system disease.
has_obo_namespace: biomarker
id: OBCI:000000041
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of respiratory system disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some respiratory system disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of cognitive disorder
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 1561
definition: A biomarker that provides clinical information about some cognitive disorder.
has_obo_namespace: biomarker
id: OBCI:000000042
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of cognitive disorder
annotated property: definition
annotated target: A biomarker that provides clinical information about some cognitive disorder.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of disease by infectious agent
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID_0050117
definition: A biomarker that provides clinical information about some disease by infectious agent.
has_obo_namespace: biomarker
id: OBCI:000000043
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of disease by infectious agent
annotated property: definition
annotated target: A biomarker that provides clinical information about some disease by infectious agent.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of disease of anatomical entity
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 7
definition: A biomarker that provides clinical information about some disease of anatomical entity.
has_obo_namespace: biomarker
id: OBCI:000000044
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of disease of anatomical entity
annotated property: definition
annotated target: A biomarker that provides clinical information about some disease of anatomical entity.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of cardiovascular system disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 1287
definition: A biomarker that provides clinical information about some cardiovascular system disease.
has_obo_namespace: biomarker
id: OBCI:000000045
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of cardiovascular system disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some cardiovascular system disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of endocrine system disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 28
definition: A biomarker that provides clinical information about some endocrine system disease.
has_obo_namespace: biomarker
id: OBCI:000000046
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of endocrine system disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some endocrine system disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of gastrointestinal system disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 77
definition: A biomarker that provides clinical information about some gastrointestinal system disease.
has_obo_namespace: biomarker
id: OBCI:000000047
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of gastrointestinal system disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some gastrointestinal system disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of hematopoietic system disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 74
definition: A biomarker that provides clinical information about some hematopoietic system disease.
has_obo_namespace: biomarker
id: OBCI:000000048
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of hematopoietic system disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some hematopoietic system disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of immune system disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 2914
definition: A biomarker that provides clinical information about some immune system disease.
has_obo_namespace: biomarker
id: OBCI:000000049
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of immune system disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some immune system disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of integumentary system disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 16
definition: A biomarker that provides clinical information about some integumentary system disease.
has_obo_namespace: biomarker
id: OBCI:000000050
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of integumentary system disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some integumentary system disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of musculoskeletal system disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 17
definition: A biomarker that provides clinical information about some musculoskeletal system disease.
has_obo_namespace: biomarker
id: OBCI:000000051
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of musculoskeletal system disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some musculoskeletal system disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of nervous system disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 863
definition: A biomarker that provides clinical information about some nervous system disease.
has_obo_namespace: biomarker
id: OBCI:000000052
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of nervous system disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some nervous system disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of reproductive system disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 15
definition: A biomarker that provides clinical information about some reproductive system disease.
has_obo_namespace: biomarker
id: OBCI:000000053
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of reproductive system disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some reproductive system disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of thoracic disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID_0060118
definition: A biomarker that provides clinical information about some thoracic disease.
has_obo_namespace: biomarker
id: OBCI:000000054
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of thoracic disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some thoracic disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of urinary system disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 18
definition: A biomarker that provides clinical information about some urinary system disease.
has_obo_namespace: biomarker
id: OBCI:000000055
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of urinary system disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some urinary system disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of disease of cellular proliferation
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID_14566
definition: A biomarker that provides clinical information about some disease of cellular proliferation.
has_obo_namespace: biomarker
id: OBCI:000000056
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of disease of cellular proliferation
annotated property: definition
annotated target: A biomarker that provides clinical information about some disease of cellular proliferation.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of disease of metabolism
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID_0014667
definition: A biomarker that provides clinical information about some disease of metabolism.
has_obo_namespace: biomarker
id: OBCI:000000057
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of disease of metabolism
annotated property: definition
annotated target: A biomarker that provides clinical information about some disease of metabolism.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

biomarker of genetic disease
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: provides_clinical_information_for
    some values from: DOID 630
definition: A biomarker that provides clinical information about some genetic disease.
has_obo_namespace: biomarker
id: OBCI:000000058
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: biomarker of genetic disease
annotated property: definition
annotated target: A biomarker that provides clinical information about some genetic disease.
database_cross_reference: https://orcid.org/0000-0001-5809-9523

saliva biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0001836
definition: A biomarker that is assessed using saliva as the anatomical source.
has_obo_namespace: biomarker
id: OBCI:000000059
created by: https://orcid.org/0000-0001-5809-9523

neutrophil-to-lymphocyte ratio in blood above normal
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_above_normal_level_of
    some values from: neutrophil-to-lymphocyte ratio
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0000178
subclass of: cellular biomarker
subclass of: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: prognostic_for
    some values from: DOID_0080600
definition: A biomarker that is indicated by an above normal neutrophil-to-lymphocyte ratio determined using a sample of blood.
has_obo_namespace: biomarker
id: OBCI:000000060
created by: https://orcid.org/0000-0001-5809-9523

neuron-specific enolase in blood above normal
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_above_normal_level_of
    some values from: PR_000050384
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0000178
subclass of: protein biomarker
subclass of: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: prognostic_for
    some values from: DOID_0080600
definition: A biomarker that is indicated by an above normal level of neuron-specific enolase determined using a sample of blood.
has_obo_namespace: biomarker
id: OBCI:000000061
created by: https://orcid.org/0000-0001-5809-9523

soluble urokinase plasminogen activator receptor in blood above normal
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_above_normal_level_of
    some values from: PR_000050323
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0000178
subclass of: protein biomarker
subclass of: Restriction
  on property: prognostic_for
  some values from: DOID_0080600
subclass of: Restriction
  on property: prognostic_for
  some values from: DOID_12365
subclass of: Restriction
  on property: prognostic_for
  some values from: DOID 2957
subclass of: Restriction
  on property: prognostic_for
  some values from: DOID 526
definition: A biomarker that is indicated by an above normal level of soluble urokinase plasminogen activator receptor determined using a sample of blood.
has_obo_namespace: biomarker
id: OBCI:000000062
created by: https://orcid.org/0000-0001-5809-9523

DNA biomarker
type: Class
subclass of: molecular biomarker
definition: A biomarker in which the assessed entity is some DNA.
IAO_0000116: This class includes cases where the assessed entity is whole DNA; that is, without regard to sequence.
IAO_0000116: This class includes cases where the biomarker assesses multiple entities of the same type (for example, by using a panel).
has_obo_namespace: biomarker
id: OBCI:000000063
created by: https://orcid.org/0000-0001-5809-9523

multi-component biomarker
type: Class
subclass of: biomarker with specified assessed entity
definition: A defined characteristic or set of characteristics derived from two or more data sources evaluated through an algorithm as an indicator of normal biological processes, pathogenic processes or responses to an exposure or intervention, including therapeutic interventions and environmental exposures.
has_obo_namespace: biomarker
id: OBCI:000000067
created by: https://orcid.org/0000-0001-5809-9523

Axiom
annotated source: multi-component biomarker
annotated property: definition
annotated target: A defined characteristic or set of characteristics derived from two or more data sources evaluated through an algorithm as an indicator of normal biological processes, pathogenic processes or responses to an exposure or intervention, including therapeutic interventions and environmental exposures.
database_cross_reference: FDA-NIH Biomarker Working Group

blood serum biomarker
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0001977
definition: A biomarker that is assessed using blood serum as the anatomical source.
has_obo_namespace: biomarker
id: OBCI:000000014
created by: https://orcid.org/0000-0001-5809-9523

voice biomarker
type: Class
subclass of: physiological characteristic biomarker
definition: A biomarker in which the assessed entity is a vocal characteristic.
has_obo_namespace: biomarker
id: OBCI:000000066
created by: https://orcid.org/0000-0001-5809-9523

blood pressure biomarker
type: Class
subclass of: physiological characteristic biomarker
definition: A biomarker in which the assessed entity is blood pressure.
has_obo_namespace: biomarker
id: OBCI:000000067
created by: https://orcid.org/0000-0001-5809-9523

microRNA-214 in urine below normal
type: Class
subclass of: RNA biomarker
definition: A biomarker that is indicated by a below normal level of microRNA-214 determined using a sample of urine.
has_obo_namespace: biomarker
id: OBCI:000000068
created by: https://orcid.org/0000-0001-5809-9523

beta-hexosaminidase level in blood above normal
type: Class
subclass of: protein biomarker
definition: A biomarker that is indicated by an above normal level of beta-hexosaminidase determined using a sample of blood.
has_obo_namespace: biomarker
id: OBCI:000000069
created by: https://orcid.org/0000-0001-5809-9523

bodily movement biomarker
type: Class
subclass of: physiological characteristic biomarker
definition: A biomarker in which the assessed entity is some bodily movement.
has_obo_namespace: biomarker
id: OBCI:000000070
created by: https://orcid.org/0000-0001-5809-9523

gait biomarker
type: Class
subclass of: bodily movement biomarker
definition: A biomarker in which the assessed entity is some manner of walking.
has_obo_namespace: biomarker
id: OBCI:000000071
created by: https://orcid.org/0000-0001-5809-9523

ocular biomarker
type: Class
subclass of: physiological characteristic biomarker
definition: A biomarker in which the assessed entity is an ocular characteristic.
has_obo_namespace: biomarker
id: OBCI:000000072
created by: https://orcid.org/0000-0001-5809-9523

red eye
type: Class
subclass of: ocular biomarker
definition: A biomarker that is indicated by an above normal level of eye redness.
has_exact_synonym: bloodshot eye
has_obo_namespace: biomarker
id: OBCI:000000073
created by: https://orcid.org/0000-0001-5809-9523

irritated sclera
type: Class
subclass of: red eye
definition: A biomarker that is indicated by an above normal level of sclera irritation.
has_obo_namespace: biomarker
id: OBCI:000000074
created by: https://orcid.org/0000-0001-5809-9523

subconjunctival hemorrhage
type: Class
subclass of: red eye
has_obo_namespace: biomarker
id: OBCI:000000075
created by: https://orcid.org/0000-0001-5809-9523

cellular morphology biomarker
type: Class
subclass of: cellular biomarker
definition: A biomarker in which the assessed entity is cellular morphology.
has_obo_namespace: biomarker
id: OBCI:000000076
created by: https://orcid.org/0000-0001-5809-9523

constricted pupil
type: Class
subclass of: ocular biomarker
has_obo_namespace: biomarker
id: OBCI:000000077
created by: https://orcid.org/0000-0001-5809-9523

dilated pupil
type: Class
subclass of: ocular biomarker
has_obo_namespace: biomarker
id: OBCI:000000078
created by: https://orcid.org/0000-0001-5809-9523

ethanol present in blood
type: Class
equivalent class: Class
  intersection of: biomarker
  intersection of: Restriction
    on property: indicated_by_presence_of
    some values from: CHEBI_29101
  intersection of: Restriction
    on property: determined_using_sample_from
    some values from: UBERON_0000178
subclass of: small molecule biomarker
definition: A biomarker that is indicated by the presence of ethanol determined using a sample of blood.
has_obo_namespace: biomarker
id: OBCI:000000079
created by: https://orcid.org/0000-0001-5809-9523

neutrophil-to-lymphocyte ratio
type: Class
subclass of: PATO_0001470
definition: A ratio between the level of neutrophils and the level of lymphocytes.
equivalent class: Class
  intersection of: Restriction
    on property: RO_0020202
    all values from: Restriction
      on property: PATO_0000033
      some values from: CL_0000775
  intersection of: Restriction
    on property: RO_0020203
    all values from: Restriction
      on property: PATO_0000033
      some values from: CL_0000542
  intersection of: Restriction
    on property: RO_0020202
    cardinality: 1
  intersection of: Restriction
    on property: RO_0020203
    cardinality: 1
has_obo_namespace: biomarker
id: OBCI:000000080
in subset: external
created by: https://orcid.org/0000-0001-5809-9523

fibrinogen-to-albumin ratio
type: Class
subclass of: PATO_0001470
definition: A ratio between the level of fibrinogen and the level of albumin.
equivalent class: Class
  intersection of: Restriction
    on property: RO_0020202
    all values from: Restriction
      on property: PATO_0000033
      some values from: GO_0005577
  intersection of: Restriction
    on property: RO_0020203
    all values from: Restriction
      on property: PATO_0000033
      some values from: PR_000003918
  intersection of: Restriction
    on property: RO_0020202
    cardinality: 1
  intersection of: Restriction
    on property: RO_0020203
    cardinality: 1
has_obo_namespace: biomarker
id: OBCI:000000081
in subset: external
created by: https://orcid.org/0000-0001-5809-9523

susceptibility/risk (BEST)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000082
created by: https://orcid.org/0000-0001-5809-9523

diagnostic (BEST)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000083
created by: https://orcid.org/0000-0001-5809-9523

monitoring (BEST)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000084
created by: https://orcid.org/0000-0001-5809-9523

prognostic (BEST)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000085
created by: https://orcid.org/0000-0001-5809-9523

predictive (BEST)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000086
created by: https://orcid.org/0000-0001-5809-9523

pharmacodynamic/response (BEST)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000087
created by: https://orcid.org/0000-0001-5809-9523

safety (BEST)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000088
created by: https://orcid.org/0000-0001-5809-9523

diagnostic (CIViC)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000089
created by: https://orcid.org/0000-0001-5809-9523

predictive (CIViC)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000090
created by: https://orcid.org/0000-0001-5809-9523

predisposing (CIViC)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000091
created by: https://orcid.org/0000-0001-5809-9523

prognostic (CIViC)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000092
created by: https://orcid.org/0000-0001-5809-9523

functional (CIViC)
type: NamedIndividual
has_obo_namespace: biomarker
id: OBCI:000000093
created by: https://orcid.org/0000-0001-5809-9523