Bioconductor Affymetrix Probe Listing

Probe log2FC AveExpr t P.Value adj.P.Val B Symbol Description Chromosome Chromosome Location GenBank Gene Cytoband UniGene PubMed Gene Ontology Pathway
1556113_at 0.751 5.615 7.028 3.782e-06 0.039 3.863 DKFZp451A211 DKFZp451A211 protein 13   BC036906 13q34 Hs.646609 1    
209190_s_at 0.516 7.858 4.753 2.472e-04 0.172 0.569 DIAPH1 diaphanous homolog 1 (Drosophila) 5 -140874771 AF051782 5q31 Hs.529451 33

actin binding

receptor binding

cytoplasm

cytoskeleton

plasma membrane

sensory perception of sound

cellular component organization

Rho GTPase binding

actin cytoskeleton organization

ruffle membrane

cell projection

Focal adhesion

Regulation of actin cytoskeleton

237116_at 1.300 7.747 5.183 1.065e-04 0.162 1.260 LOC646903 hypothetical LOC646903 3   AI262277 3q25.1 Hs.632559 1    
231968_at 0.737 7.931 5.594 4.862e-05 0.162 1.893 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 128565223, 128565251 AK025416 2q14.3 Hs.598715 Hs.719174 10

UDP-glucose:glycoprotein glucosyltransferase activity

endoplasmic reticulum

endoplasmic reticulum lumen

ER-Golgi intermediate compartment

protein amino acid glycosylation

transferase activity, transferring glycosyl groups

unfolded protein binding

'de novo' posttranslational protein folding

 
225337_at 0.816 6.878 7.329 2.291e-06 0.039 4.231 ABHD2 abhydrolase domain containing 2 15 87432384 AI346910 15q26.1 Hs.122337 Hs.705984 10

molecular_function

carboxylesterase activity

biological_process

response to wounding

membrane

integral to membrane

hydrolase activity

negative regulation of cell migration

 
227340_s_at -1.394 5.307 -4.679 2.862e-04 0.175 0.447 RGMB RGM domain family, member B 5 98132898 AL117590 5q15 Hs.526902 5

ER-Golgi intermediate compartment

plasma membrane

cell adhesion

signal transduction

BMP signaling pathway

identical protein binding

positive regulation of transcription

anchored to plasma membrane

 
219464_at -1.804 7.403 -6.790 5.661e-06 0.039 3.562 CA14 carbonic anhydrase XIV 1 148496841 NM_012113 1q21 Hs.528988 11

carbonate dehydratase activity

zinc ion binding

membrane

integral to membrane

lyase activity

metal ion binding

Nitrogen metabolism

225185_at 0.792 7.857 4.698 2.758e-04 0.175 0.478 MRAS muscle RAS oncogene homolog 3 139549314, 139550197 BF343625 3q22.3 Hs.527021 18

nucleotide binding

GTPase activity

GTP binding

intracellular

plasma membrane

Ras protein signal transduction

multicellular organismal development

muscle organ development

actin cytoskeleton organization

GTP-dependent protein binding

MAPK signaling pathway

Tight junction

Regulation of actin cytoskeleton

1556051_a_at 1.050 4.579 5.677 4.160e-05 0.152 2.017 BICD1 bicaudal D homolog 1 (Drosophila) 12 32151451 CA777994 12p11.2-p11.1 Hs.505202 17

structural constituent of cytoskeleton

protein binding

Golgi apparatus

cytoskeleton

RNA processing

transport

intracellular mRNA localization

anatomical structure morphogenesis

 
201975_at 0.335 9.896 2.922 1.039e-02 0.418 -2.589 CLIP1 CAP-GLY domain containing linker protein 1 12 -121321933 NM_002956 12q24.3 Hs.524809 37

kinetochore

nucleic acid binding

protein binding

cytoplasm

endosome

microtubule

intermediate filament

mitosis

microtubule binding

zinc ion binding

protein homodimerization activity

metal ion binding

 
206209_s_at -0.415 6.436 -3.245 5.359e-03 0.351 -2.026 CA4 carbonic anhydrase IV 17 55582083 NM_000717 17q23 Hs.89485 30

carbonate dehydratase activity

membrane fraction

plasma membrane

one-carbon metabolic process

visual perception

zinc ion binding

lyase activity

anchored to membrane

metal ion binding

response to stimulus

Nitrogen metabolism

217820_s_at 0.771 8.103 3.627 2.433e-03 0.284 -1.354 ENAH enabled homolog (Drosophila) 1 -223741156 NM_018212 1q42.12 Hs.497893 37

actin binding

cytoplasm

cytoskeleton

focal adhesion

SH3 domain binding

lamellipodium

cell junction

filopodium

synapse

intracellular transport

WW domain binding

Regulation of actin cytoskeleton

203913_s_at 0.897 2.683 6.453 1.017e-05 0.062 3.118 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 4 -175647902, -175647902 AL574184 4q34-q35 Hs.596913 47

prostaglandin E receptor activity

binding

nucleus

nucleolus

cytoplasm

cytosol

lipid metabolic process

fatty acid metabolic process

prostaglandin metabolic process

transforming growth factor beta receptor signaling pathway

female pregnancy

parturition

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

oxidoreductase activity

lipoxygenase pathway

protein homodimerization activity

negative regulation of cell cycle

NAD or NADH binding

oxidation reduction

 
214788_x_at 1.211 7.439 3.165 6.312e-03 0.363 -2.165 DDN dendrin 12 -47675199 AA731713 12q13.12 Hs.591044 5

nucleus

cytoplasm

endoplasmic reticulum

plasma membrane

dendrite

cell projection

perikaryon

 
63825_at 0.744 6.770 3.812 1.661e-03 0.263 -1.030 ABHD2 abhydrolase domain containing 2 15 87432384 AI557319 15q26.1 Hs.122337 Hs.705984 10

molecular_function

carboxylesterase activity

biological_process

response to wounding

membrane

integral to membrane

hydrolase activity

negative regulation of cell migration

 
202763_at 0.848 5.490 5.134 1.170e-04 0.162 1.183 CASP3 caspase 3, apoptosis-related cysteine peptidase 4 -185785843 NM_004346 4q34 Hs.141125 552

B cell homeostasis

release of cytochrome c from mitochondria

cysteine-type endopeptidase activity

cyclin-dependent protein kinase inhibitor activity

protein binding

nucleus

nucleoplasm

nucleolus

cytoplasm

mitochondrion

cytosol

cytosol

plasma membrane

DNA fragmentation involved in apoptosis

proteolysis

response to DNA damage stimulus

heart development

sensory perception of sound

peptidase activity

induction of apoptosis via death domain receptors

induction of apoptosis by oxidative stress

response to UV

response to wounding

keratinocyte differentiation

nuclear fragmentation during apoptosis

negative regulation of B cell proliferation

response to tumor necrosis factor

T cell homeostasis

negative regulation of apoptosis

cell fate commitment

negative regulation of cyclin-dependent protein kinase activity

negative regulation of activated T cell proliferation

neuron apoptosis

MAPK signaling pathway

p53 signaling pathway

Apoptosis

Natural killer cell mediated cytotoxicity

Alzheimer's disease

Parkinson's disease

Amyotrophic lateral sclerosis (ALS)

Huntington's disease

Epithelial cell signaling in Helicobacter pylori infection

Pathways in cancer

Colorectal cancer

209005_at 0.477 7.759 4.252 6.760e-04 0.211 -0.271 FBXL5 F-box and leucine-rich repeat protein 5 4 -15215251 AF157323 4p15.32 Hs.643433 13

ubiquitin ligase complex

ubiquitin-protein ligase activity

protein binding

protein ubiquitination

modification-dependent protein catabolic process

 
203367_at 0.371 6.604 3.562 2.785e-03 0.292 -1.469 DUSP14 dual specificity phosphatase 14 17 32924063 NM_007026 17q12 Hs.91448 5

protein tyrosine phosphatase activity

protein amino acid dephosphorylation

hydrolase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

MAPK signaling pathway

221752_at 0.632 6.388 4.042 1.038e-03 0.225 -0.632 SSH1 slingshot homolog 1 (Drosophila) 12 -107709824, -107709824, -107700595 AL041728 12q24.11 Hs.199763 23

cell morphogenesis

actin binding

protein tyrosine phosphatase activity

protein binding

cytoplasm

cytoskeleton

plasma membrane

protein amino acid dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

hydrolase activity

lamellipodium

actin cytoskeleton organization

Regulation of actin cytoskeleton

222572_at -1.430 9.672 -5.221 9.900e-05 0.162 1.319 PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 8 94998258, 94998337, 94998350, 94998454, 94999167 BG542521 8q22.1 Hs.22265 19

magnesium ion binding

protein serine/threonine phosphatase activity

[pyruvate dehydrogenase (lipoamide)] phosphatase activity

calcium ion binding

mitochondrion

mitochondrial matrix

protein amino acid dephosphorylation

protein serine/threonine phosphatase complex

hydrolase activity

 
224983_at 0.546 9.933 4.773 2.376e-04 0.172 0.602 SCARB2 scavenger receptor class B, member 2 4 -77298917 BF339821 4q21.1 Hs.349656 Hs.714206 24

receptor activity

protein binding

membrane fraction

lysosome

integral to plasma membrane

cell adhesion

membrane

Lysosome

202694_at 0.612 4.352 4.914 1.798e-04 0.171 0.831 STK17A serine/threonine kinase 17a 7 43589216 AW183478 7p12-p14 Hs.709489 6

nucleotide binding

protein serine/threonine kinase activity

ATP binding

nucleus

protein amino acid phosphorylation

apoptosis

induction of apoptosis

protein kinase cascade

transferase activity

 
238575_at 0.766 7.166 4.549 3.713e-04 0.186 0.231 OSBPL6 oxysterol binding protein-like 6 2 178767619, 178893216 AI094626 2q31-q32.1 Hs.318775 7

lipid transport

steroid metabolic process

 
218868_at 0.274 5.920 2.459 2.636e-02 0.521 -3.374 ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 7 152087783 NM_020445 7q36.1 Hs.647117 8

nucleotide binding

actin binding

protein binding

ATP binding

cytoplasm

cytoskeleton

regulation of actin filament polymerization

cell projection

 
209212_s_at 1.432 6.219 5.522 5.569e-05 0.162 1.784 KLF5 Kruppel-like factor 5 (intestinal) 13 72531142 AB030824 13q22.1 Hs.508234 50

angiogenesis

transcription factor activity

RNA polymerase II transcription factor activity

protein binding

intracellular

nucleus

regulation of transcription, DNA-dependent

transcription from RNA polymerase II promoter

zinc ion binding

positive regulation of cell proliferation

microvillus assembly

positive regulation of transcription

metal ion binding

 
203580_s_at 0.556 8.015 3.824 1.622e-03 0.260 -1.009 SLC7A6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 16 66855923 NM_003983 16q22.1 Hs.653193 Hs.709557 6

plasma membrane

integral to plasma membrane

protein complex assembly

cellular amino acid metabolic process

transport

amino acid transport

amino acid transmembrane transporter activity

antiporter activity

 
222569_at 0.833 6.279 3.949 1.256e-03 0.238 -0.793 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 128565223, 128565251 AU153746 2q14.3 Hs.598715 Hs.719174 10

UDP-glucose:glycoprotein glucosyltransferase activity

endoplasmic reticulum

endoplasmic reticulum lumen

ER-Golgi intermediate compartment

protein amino acid glycosylation

transferase activity, transferring glycosyl groups

unfolded protein binding

'de novo' posttranslational protein folding

 
222258_s_at 1.508 5.744 6.234 1.503e-05 0.075 2.817 SH3BP4 SH3-domain binding protein 4 2 235525366 AF015043 2q37.1-q37.2 Hs.516777 12

molecular_function

signal transducer activity

protein binding

cellular_component

nucleus

coated pit

endocytosis

cell cycle

biological_process

membrane

clathrin-coated vesicle

cytoplasmic vesicle

 
203700_s_at 0.766 4.945 4.543 3.754e-04 0.187 0.222 DIO2 deiodinase, iodothyronine, type II 14 -79733621, -79733621 NM_013989 14q24.2-q24.3 Hs.202354 61

selenocysteine incorporation

thyroxine 5'-deiodinase activity

thyroid hormone generation

selenium binding

membrane

integral to membrane

thyroid hormone catabolic process

hormone biosynthetic process

oxidation reduction

 
214999_s_at 1.087 4.533 5.789 3.381e-05 0.132 2.182 RAB11FIP3 RAB11 family interacting protein 3 (class II) 16 415668, 464850 AW243089 16p13.3 Hs.531642 18

calcium ion binding

protein binding

protein transport

membrane

Rab GTPase binding

recycling endosome

Endocytosis

211984_at 0.844 10.402 5.446 6.427e-05 0.162 1.669 CALM1 calmodulin 1 (phosphorylase kinase, delta) 14 89933125 AI653730 14q24-q31 Hs.282410 Hs.708270 181  

Calcium signaling pathway

Phosphatidylinositol signaling system

Vascular smooth muscle contraction

Long-term potentiation

Neurotrophin signaling pathway

Olfactory transduction

Insulin signaling pathway

GnRH signaling pathway

Melanogenesis

Alzheimer's disease

Glioma

204992_s_at 0.823 10.321 4.141 8.473e-04 0.216 -0.461 PFN2 profilin 2 3 -151165380 NM_002628 3q25.1-q25.2 Hs.91747 24

actin binding

protein binding

phosphatidylinositol-4,5-bisphosphate binding

cytoplasm

regulation of actin polymerization or depolymerization

actin cytoskeleton

actin cytoskeleton organization

Regulation of actin cytoskeleton

213745_at 0.835 2.958 3.346 4.348e-03 0.328 -1.848 ATRNL1 attractin-like 1 10 116843113 AW151108 10q26 Hs.501127 3

binding

sugar binding

membrane

integral to membrane

 
203933_at 0.525 6.466 4.562 3.614e-04 0.183 0.253 RAB11FIP3 RAB11 family interacting protein 3 (class II) 16 415668, 464850 NM_014700 16p13.3 Hs.531642 18

calcium ion binding

protein binding

protein transport

membrane

Rab GTPase binding

recycling endosome

Endocytosis

201392_s_at 0.706 8.226 3.834 1.591e-03 0.258 -0.993 IGF2R insulin-like growth factor 2 receptor 6 160310120 BG031974 6q26 Hs.487062 101

glycoprotein binding

receptor activity

insulin-like growth factor receptor activity

transporter activity

insulin-like growth factor binding

mannose binding

membrane fraction

nucleus

nuclear envelope lumen

cytoplasm

lysosome

endosome

Golgi apparatus

integral to plasma membrane

transport

receptor-mediated endocytosis

signal transduction

membrane

trans-Golgi network transport vesicle

Lysosome

211985_s_at 0.794 10.126 4.601 3.347e-04 0.179 0.317 CALM1 calmodulin 1 (phosphorylase kinase, delta) 14 89933125 AI653730 14q24-q31 Hs.282410 Hs.708270 181  

Calcium signaling pathway

Phosphatidylinositol signaling system

Vascular smooth muscle contraction

Long-term potentiation

Neurotrophin signaling pathway

Olfactory transduction

Insulin signaling pathway

GnRH signaling pathway

Melanogenesis

Alzheimer's disease

Glioma

219631_at 0.463 5.780 2.780 1.388e-02 0.442 -2.834 LRP12 low density lipoprotein-related protein 12 8 -105570642 NM_024937 8q22.2-q23.1 Hs.600630 8

receptor activity

low-density lipoprotein receptor activity

protein binding

nucleolus

cytoplasm

plasma membrane

integral to plasma membrane

coated pit

endocytosis

signal transduction

regulation of growth

 
225028_at 0.704 3.030 4.449 4.540e-04 0.193 0.063 LOC550643 hypothetical LOC550643 X 56772442 AI417268 Xp11.1 Hs.355559 1    
231935_at 0.831 7.696 3.346 4.353e-03 0.328 -1.849 ARPP-21 cyclic AMP-regulated phosphoprotein, 21 kD 3 35658852, 35696119, 35697432 AL133109 3p22.3 Hs.475902 Hs.713605 7

molecular_function

nucleic acid binding

cellular_component

cytoplasm

biological_process

 
222730_s_at 0.530 6.219 3.108 7.103e-03 0.372 -2.266 ZDHHC2 zinc finger, DHHC-type containing 2 8 17058206 AI814257 8p21.3-p22 Hs.443852 8

zinc ion binding

membrane

integral to membrane

palmitoyltransferase activity

transferase activity

protein palmitoylation

metal ion binding

 
228310_at 0.869 5.551 4.670 2.914e-04 0.175 0.432 ENAH enabled homolog (Drosophila) 1 -223741156 BF223300 1q42.12 Hs.497893 37

actin binding

cytoplasm

cytoskeleton

focal adhesion

SH3 domain binding

lamellipodium

cell junction

filopodium

synapse

intracellular transport

WW domain binding

Regulation of actin cytoskeleton

225323_at 0.223 5.917 2.520 2.339e-02 0.507 -3.274 CC2D1B coiled-coil and C2 domain containing 1B 1 -52588854 AW514783 1p32.3 Hs.591451 6    
225720_at 1.264 8.371 4.270 6.513e-04 0.211 -0.239 SYNPO2 synaptopodin 2 4 120029443, 120029443 AW009747 4q26 Hs.655519 14

actin binding

protein binding

nucleus

cytoplasm

 
224759_s_at 0.347 6.947 2.817 1.286e-02 0.432 -2.769 C12orf23 chromosome 12 open reading frame 23 12 105873673 AK001731 12q23.3 Hs.257664 3

membrane

integral to membrane

 
209345_s_at 0.513 5.779 4.941 1.707e-04 0.171 0.874 PI4K2A phosphatidylinositol 4-kinase type 2 alpha 10 99390432 AL561930 10q24 Hs.25300 18

nucleotide binding

magnesium ion binding

1-phosphatidylinositol 4-kinase activity

protein binding

ATP binding

cytoplasm

integral to plasma membrane

phosphatidylinositol biosynthetic process

membrane

kinase activity

transferase activity

membrane raft

 
204225_at 0.773 7.940 3.331 4.490e-03 0.332 -1.875 HDAC4 histone deacetylase 4 2 -239634800 NM_006037 2q37.3 Hs.20516 Hs.688314 83

histone deacetylase complex

negative regulation of transcription from RNA polymerase II promoter

skeletal system development

DNA binding

histone deacetylase activity

nucleus

cytoplasm

inflammatory response

cell cycle

multicellular organismal development

nervous system development

transcription factor binding

negative regulation of cell proliferation

transcription repressor activity

chromatin modification

hydrolase activity

B cell differentiation

positive regulation of protein sumoylation

negative regulation of striated muscle development

 
224722_at 0.306 5.014 2.330 3.399e-02 0.553 -3.585 MIB1 mindbomb homolog 1 (Drosophila) 18 17575542 BE048628 18q11.2 Hs.140903 Hs.658808 15

blood vessel development

in utero embryonic development

somitogenesis

neural tube formation

heart looping

ubiquitin-protein ligase activity

protein binding

cytoplasm

plasma membrane

Notch signaling pathway

heart development

zinc ion binding

protein ubiquitination

ligase activity

modification-dependent protein catabolic process

cytoplasmic vesicle

negative regulation of neuron differentiation

positive regulation of endocytosis

metal ion binding

 
209288_s_at 0.942 7.632 3.434 3.623e-03 0.314 -1.693 CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 2 -37724246 AL136842 2p21 Hs.369574 17

protein binding

cytoskeletal regulatory protein binding

cytoplasm

signal transduction

regulation of cell shape

actin cytoskeleton

membrane

 
222990_at 0.338 9.423 3.378 4.075e-03 0.323 -1.792 UBQLN1 ubiquilin 1 9 -85464697 AW204104 9q21.2-q21.3 9q22 Hs.9589 46

nucleus

cytoplasm

cytosol

kinase binding

protein complex

perinuclear region of cytoplasm

 
202693_s_at 0.637 5.990 3.156 6.434e-03 0.364 -2.181 STK17A serine/threonine kinase 17a 7 43589216 AW194730 7p12-p14 Hs.709489 6

nucleotide binding

protein serine/threonine kinase activity

ATP binding

nucleus

protein amino acid phosphorylation

apoptosis

induction of apoptosis

protein kinase cascade

transferase activity

 
211928_at 0.404 8.973 3.400 3.894e-03 0.319 -1.754 DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 14 101500617 AB002323 14q32 14q32.3-qter Hs.649497 33

nucleotide binding

microtubule motor activity

protein binding

ATP binding

cytoplasm

Golgi apparatus

cytoplasmic dynein complex

microtubule

microtubule-based movement

mitotic spindle organization

ATPase activity, coupled

 
222433_at 0.940 8.250 3.718 2.019e-03 0.273 -1.195 ENAH enabled homolog (Drosophila) 1 -223741156 AK025108 1q42.12 Hs.497893 37

actin binding

cytoplasm

cytoskeleton

focal adhesion

SH3 domain binding

lamellipodium

cell junction

filopodium

synapse

intracellular transport

WW domain binding

Regulation of actin cytoskeleton

222434_at 0.732 5.829 3.314 4.644e-03 0.335 -1.904 ENAH enabled homolog (Drosophila) 1 -223741156 AI963713 1q42.12 Hs.497893 37

actin binding

cytoplasm

cytoskeleton

focal adhesion

SH3 domain binding

lamellipodium

cell junction

filopodium

synapse

intracellular transport

WW domain binding

Regulation of actin cytoskeleton

225721_at 1.186 8.704 4.711 2.687e-04 0.175 0.500 SYNPO2 synaptopodin 2 4 120029443, 120029443 AI658662 4q26 Hs.655519 14

actin binding

protein binding

nucleus

cytoplasm

 
1563842_at -0.265 4.922 -3.389 3.980e-03 0.323 -1.772 PIGG phosphatidylinositol glycan anchor biosynthesis, class G 4 482988 AK097244 4p16.3 Hs.7099 8

protein binding

endoplasmic reticulum

endoplasmic reticulum membrane

metabolic process

membrane

integral to membrane

preassembly of GPI anchor in ER membrane

transferase activity

phosphotransferase activity, for other substituted phosphate groups

CP2 mannose-ethanolamine phosphotransferase activity

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

214461_at 2.945 4.182 5.265 9.097e-05 0.162 1.388 LBP lipopolysaccharide binding protein 20 36408298 NM_004139 20q11.23-q12 Hs.154078 58

lipopolysaccharide binding

macrophage activation during immune response

receptor binding

extracellular region

extracellular region

extracellular space

extracellular space

nucleus

lipid transport

acute-phase response

acute-phase response

cellular defense response

opsonization

opsonization

lipid binding

lipopolysaccharide transport

lipopolysaccharide-mediated signaling pathway

detection of molecule of bacterial origin

response to lipopolysaccharide

negative regulation of tumor necrosis factor production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of toll-like receptor 4 signaling pathway

positive regulation of macrophage activation

cell surface binding

innate immune response

innate immune response

defense response to Gram-negative bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

Gram-negative bacterial cell surface binding

Gram-negative bacterial cell surface binding

Gram-positive bacterial cell surface binding

positive regulation of respiratory burst during acute inflammatory response

Toll-like receptor signaling pathway

1554292_a_at 0.459 3.121 4.956 1.654e-04 0.171 0.900 UHRF1BP1L UHRF1 binding protein 1-like 12 -98987816, -98954993 BC014891 12q23.1 Hs.620701 2    
228647_at 0.547 6.202 3.113 7.028e-03 0.372 -2.256 LOC100049716 hypothetical protein LOC100049716 12   AI675844 12p13.33 Hs.655804 1    
205521_at 0.862 5.928 4.733 2.569e-04 0.175 0.537 EXOG endo/exonuclease (5'-3'), endonuclease G-like 3 38512766 BF511976 3p21.3 Hs.517897 6

nucleic acid binding

endonuclease activity

cellular_component

mitochondrion

mitochondrial inner membrane

biological_process

membrane

hydrolase activity

metal ion binding

Apoptosis

205105_at 0.723 6.980 3.940 1.278e-03 0.239 -0.807 MAN2A1 mannosidase, alpha, class 2A, member 1 5 109053054 NM_002372 5q21-q22 Hs.432822 29

Golgi membrane

in utero embryonic development

liver development

alpha-mannosidase activity

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

Golgi apparatus

carbohydrate metabolic process

mannose metabolic process

N-glycan processing

mitochondrion organization

vacuole organization

respiratory gaseous exchange

metabolic process

zinc ion binding

membrane

integral to membrane

hydrolase activity, hydrolyzing N-glycosyl compounds

carbohydrate binding

metal ion binding

lung alveolus development

N-Glycan biosynthesis

Metabolic pathways

206238_s_at 0.603 6.316 3.846 1.550e-03 0.254 -0.971 YAF2 YY1 associated factor 2 12 -40837173 NM_005748 12q12 Hs.708084 9

transcription coactivator activity

transcription corepressor activity

protein binding

intracellular

nucleus

zinc ion binding

negative regulation of transcription

positive regulation of transcription

metal ion binding

 
225895_at 0.885 9.185 3.609 2.529e-03 0.287 -1.386 SYNPO2 synaptopodin 2 4 120029443, 120029443 AI634580 4q26 Hs.655519 14

actin binding

protein binding

nucleus

cytoplasm

 
200928_s_at RAB14 RAB14, member RAS oncogene family 9 -122980236 AL162081 9q32-q34.11 Hs.371563 Hs.713585 19

nucleotide binding

GTPase activity

protein binding

GTP binding

intracellular

membrane fraction

lysosome

early endosome

late endosome

rough endoplasmic reticulum

Golgi stack

cytosol

plasma membrane

Golgi to endosome transport

small GTPase mediated signal transduction

neurotransmitter secretion

protein transport

vesicle-mediated transport

trans-Golgi network transport vesicle

nuclear envelope-endoplasmic reticulum network

intracellular transport

perinuclear region of cytoplasm

 
205029_s_at 2.043 4.768 3.628 2.430e-03 0.284 -1.353 FABP7 fatty acid binding protein 7, brain 6 123142344 NM_001446 6q22-q23 Hs.26770 28

transporter activity

cytoplasm

transport

nervous system development

negative regulation of cell proliferation

lipid binding

PPAR signaling pathway

209984_at 0.401 5.759 3.924 1.321e-03 0.244 -0.836 KDM4C lysine (K)-specific demethylase 4C 9 6710862, 6747640, 6747640, 6747640 AB037901 9p24.1 Hs.709425 15

molecular_function

nucleic acid binding

iron ion binding

protein binding

cellular_component

nucleus

biological_process

zinc ion binding

oxidoreductase activity

chromatin modification

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

regulation of transcription

metal ion binding

oxidation reduction

 
200862_at 1.025 7.125 2.975 9.329e-03 0.401 -2.497 DHCR24 24-dehydrocholesterol reductase 1 -55087887 NM_014762 1p33-p31.1 Hs.498727 25

nucleus

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

Golgi apparatus

cholesterol biosynthetic process

cholesterol biosynthetic process

apoptosis

anti-apoptosis

response to oxidative stress

cell cycle arrest

protein localization

tissue development

membrane

integral to membrane

membrane organization

oxidoreductase activity

enzyme binding

male genitalia development

plasminogen activation

peptide antigen binding

amyloid precursor protein catabolic process

negative regulation of caspase activity

neuroprotection

skin development

delta24-sterol reductase activity

FAD binding

oxidation reduction

Steroid biosynthesis

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

220116_at -0.486 6.122 -2.213 4.258e-02 0.576 -3.772 KCNN2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 5 113725914, 113797125 NM_021614 5q22.3 Hs.98280 15

ion channel activity

calmodulin binding

ion transport

potassium ion transport

membrane

integral to membrane

small conductance calcium-activated potassium channel activity

 
222713_s_at 0.286 4.219 3.369 4.151e-03 0.324 -1.808 FANCF Fanconi anemia, complementation group F 11 -22600654 AF181995 11p15 Hs.713574 27

molecular_function

protein binding

cellular_component

nucleus

DNA repair

response to DNA damage stimulus

biological_process

 
240453_at 1.018 3.262 6.179 1.658e-05 0.076 2.741 C20orf26 chromosome 20 open reading frame 26 20 19981195 AA418538 20p11.23 Hs.176013 6    
212239_at 0.527 7.454 2.322 3.448e-02 0.553 -3.597 PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5 67558217, 67620007, 67622250 AI680192 5q13.1 Hs.132225 Hs.604502 321

negative regulation of cell-matrix adhesion

insulin receptor binding

insulin-like growth factor receptor binding

phosphatidylinositol binding

intracellular

cytosol

cytosol

1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex

protein amino acid phosphorylation

signal transduction

insulin receptor signaling pathway

phosphoinositide 3-kinase cascade

membrane

protein phosphatase binding

B cell differentiation

positive regulation of cell migration

phosphoinositide 3-kinase regulator activity

negative regulation of apoptosis

ErbB-3 class receptor binding

insulin binding

insulin receptor substrate binding

interspecies interaction between organisms

negative regulation of osteoclast differentiation

positive regulation of glucose import

phosphoinositide phosphorylation

insulin-like growth factor receptor signaling pathway

growth hormone receptor signaling pathway

regulation of establishment of protein localization

ErbB signaling pathway

Chemokine signaling pathway

Phosphatidylinositol signaling system

mTOR signaling pathway

Apoptosis

VEGF signaling pathway

Focal adhesion

Toll-like receptor signaling pathway

Jak-STAT signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Fc gamma R-mediated phagocytosis

Leukocyte transendothelial migration

Neurotrophin signaling pathway

Regulation of actin cytoskeleton

Insulin signaling pathway

Type II diabetes mellitus

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Endometrial cancer

Glioma

Prostate cancer

Melanoma

Chronic myeloid leukemia

Acute myeloid leukemia

Small cell lung cancer

Non-small cell lung cancer

1569949_at 1.580 8.496 5.790 3.373e-05 0.132 2.184 GRK5 G protein-coupled receptor kinase 5 10 120957186 BC018116 10q24-qter Hs.524625 38

nucleotide binding

G-protein coupled receptor kinase activity

signal transducer activity

protein kinase C binding

protein binding

ATP binding

phospholipid binding

soluble fraction

cytoplasm

plasma membrane

protein amino acid phosphorylation

signal transduction

G-protein signaling, coupled to cAMP nucleotide second messenger

tachykinin receptor signaling pathway

regulation of G-protein coupled receptor protein signaling pathway

transferase activity

Chemokine signaling pathway

Endocytosis

228980_at 0.745 6.188 3.387 3.998e-03 0.323 -1.776 RFFL ring finger and FYVE-like domain containing 1 17 -30360243, -30360243 AI760772 17q12 Hs.13680 11

protein binding

cytoplasm

intracellular protein transport

apoptosis

zinc ion binding

membrane

cytoplasmic membrane-bounded vesicle

ligase activity

modification-dependent protein catabolic process

metal ion binding

 
217911_s_at 0.602 10.389 5.130 1.180e-04 0.162 1.176 BAG3 BCL2-associated athanogene 3 10 121400871 NM_004281 10q25.2-q26.2 Hs.523309 37

protein binding

cellular_component

cytosol

protein folding

anti-apoptosis

 
227973_at 0.570 6.770 3.006 8.750e-03 0.394 -2.443 C2orf69 chromosome 2 open reading frame 69 2 200484223 BF130937 2q33.1 Hs.471040 3

extracellular region

 
202917_s_at 2.351 5.693 4.435 4.664e-04 0.193 0.041 S100A8 S100 calcium binding protein A8 1 -151629131 NM_002964 1q21 Hs.416073 91

calcium ion binding

protein binding

inflammatory response

 
228977_at 1.392 7.946 3.940 1.278e-03 0.239 -0.807 LOC729680 hypothetical protein LOC729680 13   AI669535 13q12.11 Hs.130652 1    
210788_s_at 0.626 10.280 3.609 2.529e-03 0.287 -1.387 DHRS7 dehydrogenase/reductase (SDR family) member 7 14 -59681251 AF126782 14q23.1 Hs.59719 7

binding

oxidoreductase activity

oxidation reduction

 
238974_at 0.659 9.063 3.961 1.224e-03 0.234 -0.771 C2orf69 chromosome 2 open reading frame 69 2 200484223 N47077 2q33.1 Hs.471040 3

extracellular region

 
203021_at 2.318 5.977 4.496 4.124e-04 0.192 0.143 SLPI secretory leukocyte peptidase inhibitor 20 -43314292 NM_003064 20q12 Hs.517070 71

serine-type endopeptidase inhibitor activity

extracellular region

 
205030_at 2.457 6.423 3.137 6.696e-03 0.367 -2.215 FABP7 fatty acid binding protein 7, brain 6 123142344 NM_001446 6q22-q23 Hs.26770 28

transporter activity

cytoplasm

transport

nervous system development

negative regulation of cell proliferation

lipid binding

PPAR signaling pathway

200653_s_at 0.428 10.801 3.067 7.719e-03 0.380 -2.336 CALM1 calmodulin 1 (phosphorylase kinase, delta) 14 89933125 M27319 14q24-q31 Hs.282410 Hs.708270 181  

Calcium signaling pathway

Phosphatidylinositol signaling system

Vascular smooth muscle contraction

Long-term potentiation

Neurotrophin signaling pathway

Olfactory transduction

Insulin signaling pathway

GnRH signaling pathway

Melanogenesis

Alzheimer's disease

Glioma

202492_at 0.253 7.642 2.377 3.097e-02 0.542 -3.508 ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae) 2 -219792345 NM_024085 2q35 Hs.323363 10

autophagic vacuole formation

autophagy

protein transport

membrane

integral to membrane

cytoplasmic vesicle

 
240259_at 1.527 5.668 5.306 8.395e-05 0.162 1.453 FLRT2 fibronectin leucine rich transmembrane protein 2 14 85066240 AI188161 14q24-q32 Hs.533710 Hs.624735 Hs.719261 9

receptor signaling protein activity

proteinaceous extracellular matrix

integral to plasma membrane

cell adhesion

biological_process

membrane

protein binding, bridging

 
226535_at -0.675 9.547 -4.470 4.352e-04 0.193 0.098 ITGB6 integrin, beta 6 2 -160666478 AK026736 2q24.2 Hs.470399 44

receptor activity

protein binding

cell adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

integrin complex

membrane

integral to membrane

interspecies interaction between organisms

Focal adhesion

ECM-receptor interaction

Regulation of actin cytoskeleton

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

226525_at 0.828 5.070 5.114 1.216e-04 0.162 1.152 STK17B serine/threonine kinase 17b 2 -196706552 N51102 2q32.3 Hs.710234 Hs.88297 7

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

protein amino acid phosphorylation

apoptosis

induction of apoptosis

protein kinase cascade

actin cytoskeleton

transferase activity

 
208937_s_at -0.636 8.418 -2.263 3.864e-02 0.567 -3.692 ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 20 29656752 D13889 20q11 Hs.504609 112

negative regulation of transcription from RNA polymerase II promoter

protein binding

nucleus

nucleus

transforming growth factor beta receptor signaling pathway

multicellular organismal development

heart development

negative regulation of transcription by transcription factor localization

negative regulation of transcription

transcription repressor activity

BMP signaling pathway

negative regulation of transcription factor activity

blood vessel endothelial cell migration

regulation of angiogenesis

TGF-beta signaling pathway

201106_at 0.556 10.229 4.243 6.879e-04 0.211 -0.285 GPX4 glutathione peroxidase 4 (phospholipid hydroperoxidase) 19 1054935, 1055648 NM_002085 19p13.3 Hs.433951 50

glutathione peroxidase activity

soluble fraction

nucleus

nuclear envelope

cytoplasm

mitochondrion

mitochondrial inner membrane

cytosol

chromatin organization

phospholipid metabolic process

glutathione metabolic process

response to oxidative stress

multicellular organismal development

spermatogenesis

selenium binding

oxidoreductase activity

hydrogen peroxide catabolic process

glutathione binding

phospholipid-hydroperoxide glutathione peroxidase activity

regulation of inflammatory response

oxidation reduction

Glutathione metabolism

Arachidonic acid metabolism

231969_at 0.726 6.188 3.209 5.770e-03 0.357 -2.089 STOX2 storkhead box 2 4 185063502 AB037813 4q35.1 Hs.21958 Hs.696657 3    
224709_s_at 0.351 6.971 2.773 1.406e-02 0.444 -2.845 CDC42SE2 CDC42 small effector 2 5 130627600 AF131831 5q23.3-q31.1 Hs.508829 Hs.713870 8

structural molecule activity

protein binding

cytoplasm

cytoskeleton

plasma membrane

phagocytosis

regulation of cell shape

regulation of signal transduction

 
212742_at 0.655 9.480 3.004 8.785e-03 0.394 -2.446 RNF115 ring finger protein 115 1 144322392 AL530462 1q21.1 Hs.523550 8

protein binding

zinc ion binding

metal ion binding

 
225192_at 0.698 7.570 4.998 1.525e-04 0.171 0.967 C10orf46 chromosome 10 open reading frame 46 10 -120430483 AA044726 10q26.11 Hs.719193 4

ubiquitin-dependent protein catabolic process

cullin-RING ubiquitin ligase complex

ubiquitin protein ligase binding

 
203914_x_at 0.828 5.134 3.783 1.765e-03 0.268 -1.081 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 4 -175647902, -175647902 NM_000860 4q34-q35 Hs.596913 47

prostaglandin E receptor activity

binding

nucleus

nucleolus

cytoplasm

cytosol

lipid metabolic process

fatty acid metabolic process

prostaglandin metabolic process

transforming growth factor beta receptor signaling pathway

female pregnancy

parturition

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

oxidoreductase activity

lipoxygenase pathway

protein homodimerization activity

negative regulation of cell cycle

NAD or NADH binding

oxidation reduction

 
212599_at AUTS2 autism susceptibility candidate 2 7 68701840, 68701841, 68701841 AK025298 7q11.22 Hs.654801 Hs.712991 13

molecular_function

cellular_component

biological_process

 
201681_s_at 0.670 7.124 2.992 9.002e-03 0.396 -2.467 DLG5 discs, large homolog 5 (Drosophila) 10 -79220554 AB011155 10q23 Hs.652690 49

protein binding

intracellular

cytoplasm

plasma membrane

cell-cell adherens junction

intracellular signaling cascade

negative regulation of cell proliferation

cell-cell adhesion

cell junction

receptor signaling complex scaffold activity

regulation of apoptosis

 
212297_at 0.311 5.468 2.361 3.195e-02 0.545 -3.534 ATP13A3 ATPase type 13A3 3 -195604691 BF218804 3q29 Hs.529609 11

nucleotide binding

magnesium ion binding

ATP binding

ATP biosynthetic process

cation transport

metabolic process

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

membrane

integral to membrane

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

ATPase activity

 
201393_s_at 0.837 8.969 4.400 5.011e-04 0.201 -0.019 IGF2R insulin-like growth factor 2 receptor 6 160310120 NM_000876 6q26 Hs.487062 101

glycoprotein binding

receptor activity

insulin-like growth factor receptor activity

transporter activity

insulin-like growth factor binding

mannose binding

membrane fraction

nucleus

nuclear envelope lumen

cytoplasm

lysosome

endosome

Golgi apparatus

integral to plasma membrane

transport

receptor-mediated endocytosis

signal transduction

membrane

trans-Golgi network transport vesicle

Lysosome

210967_x_at 0.303 9.549 2.885 1.120e-02 0.426 -2.653 CACNB1 calcium channel, voltage-dependent, beta 1 subunit 17 -34586914, -34583234 M92301 17q21-q22 Hs.635 18

voltage-gated ion channel activity

voltage-gated calcium channel activity

calcium ion binding

plasma membrane

voltage-gated calcium channel complex

ion transport

calcium ion transport

MAPK signaling pathway

Cardiac muscle contraction

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

212765_at 0.422 7.042 3.176 6.174e-03 0.361 -2.146 CAMSAP1L1 calmodulin regulated spectrin-associated protein 1-like 1 1 198975308 AB029001 1q32.1 Hs.23585 6    
204976_s_at 0.486 5.380 3.981 1.174e-03 0.231 -0.736 AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 X -109324069 AK023637 Xq22.3 Hs.656243 7

molecular_function

cellular_component

biological_process

 
204094_s_at 0.484 8.315 3.427 3.679e-03 0.314 -1.705 TSC22D2 TSC22 domain family, member 2 3 151609477 NM_014779 3q25.1 Hs.665220 Hs.715600 5

transcription factor activity

regulation of transcription, DNA-dependent

 
228813_at 0.918 8.494 3.799 1.706e-03 0.267 -1.053 HDAC4 histone deacetylase 4 2 -239634800 AW206037 2q37.3 Hs.20516 Hs.688314 83

histone deacetylase complex

negative regulation of transcription from RNA polymerase II promoter

skeletal system development

DNA binding

histone deacetylase activity

nucleus

cytoplasm

inflammatory response

cell cycle

multicellular organismal development

nervous system development

transcription factor binding

negative regulation of cell proliferation

transcription repressor activity

chromatin modification

hydrolase activity

B cell differentiation

positive regulation of protein sumoylation

negative regulation of striated muscle development

 
227080_at 0.565 5.638 3.428 3.672e-03 0.314 -1.704 ZNF697 zinc finger protein 697 1 -119963522 AW003092 1p12 Hs.381105 Hs.711175 1

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
204175_at 0.614 7.909 3.147 6.549e-03 0.365 -2.196 ZNF593 zinc finger protein 593 1 26368974 NM_015871 1p36.11 Hs.477273 6

negative regulation of transcription from RNA polymerase II promoter

DNA binding

transcription corepressor activity

intracellular

nucleus

nucleolus

zinc ion binding

regulation of transcription

metal ion binding

 
212565_at 0.751 6.648 4.108 9.056e-04 0.220 -0.517 STK38L serine/threonine kinase 38 like 12 27288344 BE302191 12p11.23 Hs.184523 15

nucleotide binding

magnesium ion binding

actin binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

protein amino acid phosphorylation

protein kinase cascade

actin cytoskeleton

transferase activity

regulation of cellular component organization

 
235815_at -0.285 3.830 -2.974 9.340e-03 0.401 -2.498 TSHZ2 teashirt zinc finger homeobox 2 20 51022283 BE222470 20q13.2 Hs.271605 Hs.473117 Hs.649877 6

transcription factor activity

intracellular

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
225833_at 0.481 4.188 2.915 1.054e-02 0.418 -2.601 DAGLB diacylglycerol lipase, beta 7 -6415272 BE795104 7p22.1 Hs.487498 9

triacylglycerol lipase activity

calcium ion binding

plasma membrane

integral to membrane

lipid catabolic process

hydrolase activity

 
226653_at 0.726 4.608 4.876 1.939e-04 0.172 0.769 MARK1 MAP/microtubule affinity-regulating kinase 1 1 218768190 AB040910 1q41 Hs.497806 27

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

ATP binding

cytoplasm

protein amino acid phosphorylation

cytoskeleton organization

protein kinase cascade

microtubule cytoskeleton

transferase activity

 
212589_at 0.635 8.264 4.253 6.738e-04 0.211 -0.268 RRAS2 related RAS viral (r-ras) oncogene homolog 2 11 -14256041, -14256041 AI753792 11p15.2 Hs.502004 25

nucleotide binding

GTPase activity

protein binding

GTP binding

intracellular

endoplasmic reticulum

plasma membrane

Ras protein signal transduction

cellular process

positive regulation of cell migration

MAPK signaling pathway

Tight junction

Regulation of actin cytoskeleton

238592_at PDLIM3 PDZ and LIM domain 3 4 -186659844 BE840636 4q35 Hs.85862 12

nucleus

nucleolus

cytoplasm

actin filament organization

heart development

cytoskeletal protein binding

zinc ion binding

structural constituent of muscle

actin cytoskeleton

Z disc

metal ion binding

 
226989_at -1.180 7.030 -3.263 5.163e-03 0.347 -1.994 RGMB RGM domain family, member B 5 98132898 BE855765 5q15 Hs.526902 5

ER-Golgi intermediate compartment

plasma membrane

cell adhesion

signal transduction

BMP signaling pathway

identical protein binding

positive regulation of transcription

anchored to plasma membrane

 
228153_at 0.566 9.778 3.326 4.536e-03 0.332 -1.884 RNF144B ring finger protein 144B 6 18495572 AI953847 6p22.3 Hs.148741 6

ubiquitin ligase complex

ubiquitin-protein ligase activity

protein binding

apoptosis

zinc ion binding

membrane

integral to membrane

ligase activity

modification-dependent protein catabolic process

protein ubiquitination during ubiquitin-dependent protein catabolic process

metal ion binding

 
220949_s_at 0.431 7.049 3.212 5.734e-03 0.357 -2.083 C7orf49 chromosome 7 open reading frame 49 7 -134501071 NM_024033 7q33 Hs.521213 4

cytoplasm

 
215167_at -1.082 6.711 -4.184 7.760e-04 0.211 -0.387 MED14 mediator complex subunit 14 X -40393738 BE567032 Xp11.4-p11.2 Hs.407604 33

receptor activity

protein binding

nucleus

transcription initiation from RNA polymerase II promoter

RNA polymerase II transcription mediator activity

ligand-dependent nuclear receptor transcription coactivator activity

androgen receptor signaling pathway

vitamin D receptor binding

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

thyroid hormone receptor binding

 
1555487_a_at 0.203 5.670 2.353 3.250e-02 0.547 -3.548 ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 7 152087783 BC015207 7q36.1 Hs.647117 8

nucleotide binding

actin binding

protein binding

ATP binding

cytoplasm

cytoskeleton

regulation of actin filament polymerization

cell projection

 
203693_s_at 0.377 6.387 2.726 1.548e-02 0.458 -2.926 E2F3 E2F transcription factor 3 6 20510115 NM_001949 6p22 Hs.269408 Hs.703174 48

transcription factor activity

protein binding

nucleus

nucleoplasm

transcription factor complex

regulation of transcription, DNA-dependent

transcription initiation from RNA polymerase II promoter

cell cycle

Cell cycle

Pathways in cancer

Pancreatic cancer

Glioma

Prostate cancer

Melanoma

Bladder cancer

Chronic myeloid leukemia

Small cell lung cancer

Non-small cell lung cancer

235132_at 0.642 6.248 4.902 1.842e-04 0.171 0.811 LOC254128 hypothetical protein LOC254128 2   BF939830 2q14.2 Hs.712685 1    
201724_s_at 0.306 6.968 2.634 1.861e-02 0.486 -3.081 GALNT1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) 18 31488530 NM_020474 18q12.1 Hs.514806 26

polypeptide N-acetylgalactosaminyltransferase activity

calcium ion binding

sugar binding

extracellular region

Golgi apparatus

membrane

integral to membrane

transferase activity, transferring glycosyl groups

protein amino acid O-linked glycosylation via serine

protein amino acid O-linked glycosylation via threonine

manganese ion binding

perinuclear region of cytoplasm

O-Glycan biosynthesis

Metabolic pathways

218618_s_at 0.892 5.976 4.500 4.092e-04 0.192 0.150 FNDC3B fibronectin type III domain containing 3B 3 173240111, 173241037 NM_022763 3q26.31 Hs.159430 9

endoplasmic reticulum

membrane

integral to membrane

 
220359_s_at 1.814 4.646 4.195 7.596e-04 0.211 -0.369 ARPP-21 cyclic AMP-regulated phosphoprotein, 21 kD 3 35658852, 35696119, 35697432 NM_016300 3p22.3 Hs.475902 Hs.713605 7

molecular_function

nucleic acid binding

cellular_component

cytoplasm

biological_process

 
1556114_a_at 0.902 9.046 4.948 1.681e-04 0.171 0.887 DKFZp451A211 DKFZp451A211 protein 13   BC036906 13q34 Hs.646609 1    
65630_at 0.563 6.360 4.086 9.469e-04 0.223 -0.554 TMEM80 transmembrane protein 80 11 685615 AI742455 11p15.5 Hs.448664 2

membrane

integral to membrane

 
232172_at 0.316 4.887 2.912 1.061e-02 0.418 -2.607 LOC401577 hypothetical protein LOC401577 X, Y   AK023533 Xp22.33 Yp11.31 Hs.444541 2    
223168_at 0.728 8.352 3.769 1.818e-03 0.270 -1.106 RHOU ras homolog gene family, member U 1 226937491 AL096776 1q42.11-q42.3 Hs.647774 12

G1/S transition of mitotic cell cycle

nucleotide binding

magnesium ion binding

podosome

GTPase activity

protein binding

GTP binding

intracellular

Golgi apparatus

plasma membrane

focal adhesion

small GTPase mediated signal transduction

regulation of cell shape

Rac protein signal transduction

actin cytoskeleton organization

cell junction

cell projection

 
204156_at QSK serine/threonine-protein kinase QSK 11 -116219327 AA044154 11q23.3 Hs.167451 14

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

protein amino acid phosphorylation

transferase activity

 
217716_s_at 0.354 6.988 3.324 4.552e-03 0.332 -1.887 SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 3 129253901 NM_013336 3q21.3 Hs.518236 14

protein binding

endoplasmic reticulum

protein transport

P-P-bond-hydrolysis-driven protein transmembrane transporter activity

membrane

integral to membrane

ribosome binding

intracellular protein transmembrane transport

Vibrio cholerae infection

206996_x_at 0.248 9.524 2.364 3.179e-02 0.544 -3.530 CACNB1 calcium channel, voltage-dependent, beta 1 subunit 17 -34586914, -34583234 NM_000723 17q21-q22 Hs.635 18

voltage-gated ion channel activity

voltage-gated calcium channel activity

calcium ion binding

plasma membrane

voltage-gated calcium channel complex

ion transport

calcium ion transport

MAPK signaling pathway

Cardiac muscle contraction

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

201586_s_at 0.324 7.590 3.149 6.529e-03 0.364 -2.194 SFPQ splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated) 1 -35421789 NM_005066 1p34.3 Hs.355934 47

nucleotide binding

DNA binding

RNA binding

protein binding

nucleus

DNA repair

DNA recombination

mRNA processing

response to DNA damage stimulus

RNA splicing

nuclear matrix

regulation of transcription

 
205003_at -0.288 7.291 -2.478 2.541e-02 0.515 -3.343 DOCK4 dedicator of cytokinesis 4 7 -111153399 NM_014705 7q31.1 Hs.654652 16

guanyl-nucleotide exchange factor activity

protein binding

membrane

SH3 domain binding

PDZ domain binding

Rac GTPase activator activity

stereocilium

Rac GTPase binding

 
37996_s_at 0.629 6.701 3.102 7.192e-03 0.374 -2.276 DMPK dystrophia myotonica-protein kinase 19 -50964815, -50964815 L08835 19q13.3 Hs.631596 91

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

protein modification process

protein amino acid phosphorylation

regulation of heart contraction

transferase activity

 
225731_at 0.492 5.190 3.511 3.093e-03 0.302 -1.558 ANKRD50 ankyrin repeat domain 50 4 -125804915 BF196876 4q28.1 Hs.480694 3    
1555259_at 0.435 5.978 2.420 2.850e-02 0.532 -3.439 ZAK sterile alpha motif and leucine zipper containing kinase AZK 2 173648810, 173648810 AF465843 2q24.2 Hs.444451 24

cell cycle checkpoint

DNA damage checkpoint

nucleotide binding

activation of MAPKK activity

magnesium ion binding

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

protein tyrosine kinase activity

ATP binding

nucleus

cytoplasm

response to stress

cell cycle

cell cycle arrest

protein kinase cascade

activation of JUN kinase activity

cell death

cell proliferation

response to radiation

transferase activity

cell differentiation

identical protein binding

positive regulation of apoptosis

MAPK signaling pathway

Tight junction

211652_s_at 2.064 4.811 4.239 6.936e-04 0.211 -0.292 LBP lipopolysaccharide binding protein 20 36408298 M35533 20q11.23-q12 Hs.154078 58

lipopolysaccharide binding

macrophage activation during immune response

receptor binding

extracellular region

extracellular region

extracellular space

extracellular space

nucleus

lipid transport

acute-phase response

acute-phase response

cellular defense response

opsonization

opsonization

lipid binding

lipopolysaccharide transport

lipopolysaccharide-mediated signaling pathway

detection of molecule of bacterial origin

response to lipopolysaccharide

negative regulation of tumor necrosis factor production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of toll-like receptor 4 signaling pathway

positive regulation of macrophage activation

cell surface binding

innate immune response

innate immune response

defense response to Gram-negative bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

Gram-negative bacterial cell surface binding

Gram-negative bacterial cell surface binding

Gram-positive bacterial cell surface binding

positive regulation of respiratory burst during acute inflammatory response

Toll-like receptor signaling pathway

219353_at 0.390 7.093 2.214 4.249e-02 0.575 -3.770 NHLRC2 NHL repeat containing 2 10 115604409 NM_017687 10q25.3 Hs.369924 Hs.594372 2

cell redox homeostasis

 
209286_at 1.202 6.516 3.551 2.849e-03 0.296 -1.488 CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 2 -37724246 AI754416 2p21 Hs.369574 17

protein binding

cytoskeletal regulatory protein binding

cytoplasm

signal transduction

regulation of cell shape

actin cytoskeleton

membrane

 
223169_s_at 0.644 5.662 4.214 7.298e-04 0.211 -0.335 RHOU ras homolog gene family, member U 1 226937491 AB051826 1q42.11-q42.3 Hs.647774 12

G1/S transition of mitotic cell cycle

nucleotide binding

magnesium ion binding

podosome

GTPase activity

protein binding

GTP binding

intracellular

Golgi apparatus

plasma membrane

focal adhesion

small GTPase mediated signal transduction

regulation of cell shape

Rac protein signal transduction

actin cytoskeleton organization

cell junction

cell projection

 
218273_s_at -1.333 7.566 -4.439 4.629e-04 0.193 0.047 PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 8 94998258, 94998337, 94998350, 94998454, 94999167 NM_018444 8q22.1 Hs.22265 19

magnesium ion binding

protein serine/threonine phosphatase activity

[pyruvate dehydrogenase (lipoamide)] phosphatase activity

calcium ion binding

mitochondrion

mitochondrial matrix

protein amino acid dephosphorylation

protein serine/threonine phosphatase complex

hydrolase activity

 
224865_at FAR1 fatty acyl CoA reductase 1 11 13646781 N63551 11p15.2 Hs.501991 10

protein binding

peroxisome

lipid biosynthetic process

membrane

integral to membrane

oxidoreductase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

oxidation reduction

 
233919_s_at 0.219 6.234 2.288 3.685e-02 0.561 -3.652 HABP4 hyaluronan binding protein 4 9 98252234 BF213501 9q22.3-q31 Hs.494567 15

nucleus

cytoplasm

regulation of transcription

 
1565389_s_at -0.369 5.042 -4.450 4.527e-04 0.193 0.065 GRM5 glutamate receptor, metabotropic 5 11 -87877392, -87877392 S64316 11q14.2-q14.3 Hs.147361 Hs.680431 Hs.719168 33

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway

synaptic transmission

glutamate receptor activity

Calcium signaling pathway

Neuroactive ligand-receptor interaction

Gap junction

Long-term potentiation

Long-term depression

Huntington's disease

226563_at 0.523 6.864 4.397 5.034e-04 0.201 -0.023 SMAD2 SMAD family member 2 18 -43613464, -43613463, -43613463 BF793454 18q21.1 Hs.12253 Hs.705764 206

mesoderm formation

double-stranded DNA binding

transcription factor activity

intracellular

nucleus

nucleoplasm

cytoplasm

cytosol

SMAD protein complex assembly

intracellular signaling cascade

zygotic determination of dorsal/ventral axis

gastrulation

transcription factor binding

anterior/posterior pattern formation

positive regulation of epithelial to mesenchymal transition

promoter binding

transcription activator activity

regulation of transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

primary microRNA processing

ubiquitin protein ligase binding

activin responsive factor complex

type I transforming growth factor beta receptor binding

positive regulation of gene-specific transcription

cell fate commitment

negative regulation of transcription, DNA-dependent

positive regulation of transcription from RNA polymerase II promoter

paraxial mesoderm morphogenesis

regulation of binding

palate development

co-SMAD binding

R-SMAD binding

response to cholesterol

Cell cycle

Wnt signaling pathway

TGF-beta signaling pathway

Adherens junction

Pathways in cancer

Colorectal cancer

Pancreatic cancer

212993_at NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 9 -138043023 AA114166 9q34.3 Hs.112895 3

protein binding

nucleus

positive regulation of cell proliferation

negative regulation of transcription

specific transcriptional repressor activity

nuclear body

protein homooligomerization

 
242029_at 0.504 6.163 4.334 5.729e-04 0.211 -0.132 FNDC3B fibronectin type III domain containing 3B 3 173240111, 173241037 N32832 3q26.31 Hs.159430 9

endoplasmic reticulum

membrane

integral to membrane

 
204476_s_at 0.631 5.336 3.990 1.155e-03 0.231 -0.722 PC pyruvate carboxylase 11 -66372572, -66372572 NM_022172 11q13.4-q13.5 Hs.89890 26

nucleotide binding

pyruvate carboxylase activity

pyruvate carboxylase activity

ATP binding

soluble fraction

cytoplasm

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

mitochondrial matrix

gluconeogenesis

oxaloacetate metabolic process

metabolic process

lipid biosynthetic process

biotin binding

ligase activity

manganese ion binding

carboxylic acid binding

metal ion binding

Citrate cycle (TCA cycle)

Pyruvate metabolism

Metabolic pathways

233814_at -0.262 4.042 -2.264 3.862e-02 0.567 -3.691 EFNA5 ephrin-A5 5 -106740488 AK025909 5q21 Hs.288741 27

protein binding

extracellular space

plasma membrane

cell-cell signaling

multicellular organismal development

nervous system development

cell differentiation

anchored to plasma membrane

ephrin receptor binding

Axon guidance

215102_at 0.401 4.330 3.583 2.667e-03 0.290 -1.432 DPY19L1P1 dpy-19-like 1 pseudogene 1 (C. elegans) 7   AK026768 7p14.3 Hs.633705      
234317_s_at 0.596 5.728 3.703 2.083e-03 0.275 -1.222 STOX2 storkhead box 2 4 185063502 AL390216 4q35.1 Hs.21958 Hs.696657 3    
217359_s_at 0.754 3.700 3.202 5.855e-03 0.357 -2.101 NCAM1 neural cell adhesion molecule 1 11 112337204, 112337204 M22094 11q23.1 Hs.503878 120

protein binding

extracellular region

plasma membrane

cell adhesion

integral to membrane

anchored to membrane

Cell adhesion molecules (CAMs)

Prion diseases

224281_s_at 0.464 9.795 4.432 4.695e-04 0.193 0.035 NGRN neugrin, neurite outgrowth associated 15 88609898 AF225423 15q26.1 Hs.715556 Hs.716378 2

molecular_function

nucleus

multicellular organismal development

nervous system development

neuron differentiation

 
228594_at -0.451 7.140 -5.045 1.391e-04 0.169 1.042 C5orf33 chromosome 5 open reading frame 33 5 -36228450, -36228450 H94910 5p13.2 Hs.81907 3

NAD+ kinase activity

metabolic process

 
222656_at 1.010 6.165 4.109 9.044e-04 0.220 -0.516 UBE2W ubiquitin-conjugating enzyme E2W (putative) 8 -74865393 AI625741 8q21.11 Hs.597486 7

nucleotide binding

ubiquitin-protein ligase activity

ATP binding

ligase activity

modification-dependent protein catabolic process

post-translational protein modification

regulation of protein metabolic process

Ubiquitin mediated proteolysis

212585_at 0.647 7.101 3.426 3.684e-03 0.314 -1.707 OSBPL8 oxysterol binding protein-like 8 12 -75269708 BF970829 12q14 Hs.430849 13

lipid transport

steroid metabolic process

 
227406_at 0.618 6.757 3.816 1.649e-03 0.263 -1.023 LOC100129387 hypothetical LOC100129387 15 48433662 AI286203 15q21.2 Hs.659360 1    
243009_at -0.734 5.692 -4.912 1.805e-04 0.171 0.828 LOC441242 hypothetical LOC441242 7   AW513654 7q11.21 Hs.656146 2    
209563_x_at 0.531 11.120 4.206 7.427e-04 0.211 -0.350 CALM1 calmodulin 1 (phosphorylase kinase, delta) 14 89933125 BC000454 14q24-q31 Hs.282410 Hs.708270 181  

Calcium signaling pathway

Phosphatidylinositol signaling system

Vascular smooth muscle contraction

Long-term potentiation

Neurotrophin signaling pathway

Olfactory transduction

Insulin signaling pathway

GnRH signaling pathway

Melanogenesis

Alzheimer's disease

Glioma

205335_s_at 0.346 8.585 3.573 2.720e-03 0.290 -1.449 SRP19 signal recognition particle 19kDa 5 112224891 NM_003135 5q21-q22 Hs.637001 14

nucleolus

cytoplasm

signal recognition particle, endoplasmic reticulum targeting

SRP-dependent cotranslational protein targeting to membrane

7S RNA binding

response to drug

Protein export

244572_at -0.981 7.073 -3.634 2.399e-03 0.284 -1.342 KY kyphoscoliosis peptidase 3 -135801454 AI147310 3q22.2 Hs.146730 4

cytoplasm

cytoskeleton

peptidase activity

 
212791_at C1orf216 chromosome 1 open reading frame 216 1 -35952063 AL042729 1p34.3 Hs.112023 3    
232183_at SERAC1 serine active site containing 1 6 -158450523 AA128978 6q25.3 Hs.154706 6

binding

membrane

integral to membrane

 
242056_at 0.645 7.261 4.665 2.941e-04 0.175 0.425 TRIM45 tripartite motif-containing 45 1 -117455199 AI793200 1p13.1 Hs.301526 8

protein binding

intracellular

nucleus

cytoplasm

zinc ion binding

metal ion binding

 
1555882_at 1.306 3.612 4.568 3.572e-04 0.183 0.263 SPIN3 spindlin family, member 3 X -57033988, -57019529 AJ271379 Xp11.21 Hs.522672 6

gamete generation

 
220201_at 0.425 5.261 3.537 2.935e-03 0.298 -1.513 RC3H2 ring finger and CCCH-type zinc finger domains 2 9 -124655844, -124651552 NM_018835 9q34 Hs.533499 6

DNA binding

protein binding

membrane fraction

cytoplasm

biological_process

zinc ion binding

cell surface

membrane

metal ion binding

perinuclear region of cytoplasm

 
209612_s_at ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 4 -100446549 M24317 4q21-q23 Hs.4 193

alcohol dehydrogenase (NAD) activity

binding

cytoplasm

ethanol oxidation

zinc ion binding

oxidoreductase activity

metal ion binding

oxidation reduction

Glycolysis / Gluconeogenesis

Fatty acid metabolism

Tyrosine metabolism

1- and 2-Methylnaphthalene degradation

3-Chloroacrylic acid degradation

Retinol metabolism

Metabolism of xenobiotics by cytochrome P450

Drug metabolism - cytochrome P450

Metabolic pathways

226280_at 0.422 8.481 3.599 2.578e-03 0.287 -1.403 BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 15 -57742353 AA133277 15q22.2 Hs.646490 15

GTPase activator activity

calcium ion binding

protein binding

nuclear envelope

cytoplasm

apoptosis

anti-apoptosis

intracellular membrane-bounded organelle

perinuclear region of cytoplasm

 
225057_at 0.514 7.770 3.007 8.743e-03 0.394 -2.442 SLC15A4 solute carrier family 15, member 4 12 -127843692 AI636759 12q24.32-q24.33 Hs.507260 Hs.699387 6

transporter activity

oligopeptide transport

protein transport

symporter activity

membrane

integral to membrane

 
224758_at 0.299 4.495 2.474 2.561e-02 0.517 -3.350 PL-5283 PL-5283 protein 7 134997760 BG393032 7q33 Hs.200022 3    
210993_s_at 0.754 7.248 4.919 1.781e-04 0.171 0.839 SMAD1 SMAD family member 1 4 146622400, 146623406 U54826 4q31 Hs.604588 118

MAPKKK cascade

mesodermal cell fate commitment

osteoblast fate commitment

transcription factor activity

RNA polymerase II transcription factor activity

receptor signaling protein activity

intracellular

nucleus

nucleoplasm

transcription factor complex

cytoplasm

cytosol

inflammatory response

signal transduction

transforming growth factor beta receptor signaling pathway

SMAD protein complex assembly

gamete generation

negative regulation of cell proliferation

embryonic pattern specification

positive regulation of gene expression

integral to membrane

transcription activator activity

BMP signaling pathway

BMP signaling pathway

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

midbrain development

hindbrain development

primary microRNA processing

homeostatic process

identical protein binding

positive regulation of osteoblast differentiation

positive regulation of transcription from RNA polymerase II promoter

co-SMAD binding

TGF-beta signaling pathway

1560018_at ARPP-21 cyclic AMP-regulated phosphoprotein, 21 kD 3 35658852, 35696119, 35697432 H44077 3p22.3 Hs.475902 Hs.713605 7

molecular_function

nucleic acid binding

cellular_component

cytoplasm

biological_process

 
209287_s_at 0.492 6.135 4.369 5.333e-04 0.207 -0.072 CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 2 -37724246 AF104857 2p21 Hs.369574 17

protein binding

cytoskeletal regulatory protein binding

cytoplasm

signal transduction

regulation of cell shape

actin cytoskeleton

membrane

 
224898_at 0.524 5.465 3.093 7.321e-03 0.376 -2.291 WDR26 WD repeat domain 26 1 -222639467 BG177759 1q42.11-q42.12 Hs.497873 8

cytoplasm

 
214033_at 0.400 5.924 2.717 1.575e-02 0.459 -2.941 ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 16 -16222544, -16150922 AI084637 16p13.1 Hs.442182 70

nucleotide binding

transporter activity

ATP binding

plasma membrane

transport

visual perception

integral to membrane

ATPase activity

response to drug

ATPase activity, coupled to transmembrane movement of substances

response to stimulus

ABC transporters

221232_s_at ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 10 99322245 NM_020349 10q23.31-q23.32 Hs.73708 17

muscle organ development

structural constituent of muscle

I band

 
235070_at 0.633 8.267 4.836 2.095e-04 0.172 0.705 A2BP1 ataxin 2-binding protein 1 16 6009132, 6763810, 7322751 AL133898 16p13.3 Hs.459842 22

nucleotide binding

RNA binding

nucleus

cytoplasm

trans-Golgi network

mRNA processing

protein C-terminus binding

RNA splicing

RNA transport

 
215903_s_at 0.312 8.195 2.841 1.225e-02 0.427 -2.729 MAST2 microtubule associated serine/threonine kinase 2 1 46041871 BE786598 1p34.1 Hs.319481 19

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

cytoskeleton

plasma membrane

protein amino acid phosphorylation

transferase activity

phosphatase binding

regulation of interleukin-12 biosynthetic process

spermatid differentiation

 
218829_s_at CHD7 chromodomain helicase DNA binding protein 7 8 61753892 NM_017780 8q12.1-q12.2 Hs.20395 36

nucleotide binding

chromatin

skeletal system development

blood vessel development

in utero embryonic development

heart morphogenesis

DNA binding

chromatin binding

helicase activity

ATP binding

nucleus

chromatin assembly or disassembly

central nervous system development

adult heart development

sensory perception of sound

locomotory behavior

adult walking behavior

blood circulation

chromatin modification

hydrolase activity

cranial nerve development

T cell differentiation

female genitalia development

embryonic hindlimb morphogenesis

positive regulation of multicellular organism growth

inner ear morphogenesis

nose development

regulation of transcription

cognition

palate development

retina development in camera-type eye

regulation of growth hormone secretion

limb development

face development

 
212843_at 0.943 5.000 3.774 1.799e-03 0.270 -1.098 NCAM1 neural cell adhesion molecule 1 11 112337204, 112337204 AA126505 11q23.1 Hs.503878 120

protein binding

extracellular region

plasma membrane

cell adhesion

integral to membrane

anchored to membrane

Cell adhesion molecules (CAMs)

Prion diseases

219806_s_at 0.702 5.718 3.893 1.407e-03 0.247 -0.889 C11orf75 chromosome 11 open reading frame 75 11 -92851286 NM_020179 11q13.3-q23.3 Hs.438064 3

molecular_function

cellular_component

biological_process

membrane

integral to membrane

 
1555960_at 0.583 4.400 3.904 1.376e-03 0.245 -0.870 HINT1 histidine triad nucleotide binding protein 1 5 -130522773, -130522773 AK054976 5q31.2 Hs.483305 26

protein kinase C binding

nucleus

cytoplasm

cytoskeleton

signal transduction

hydrolase activity

 
232000_at 1.178 3.038 4.996 1.532e-04 0.171 0.963 TTC39B tetratricopeptide repeat domain 39B 9 -15161560 AW001030 9p22.3 Hs.563630 3

binding

 
216115_at 0.353 5.019 3.489 3.239e-03 0.306 -1.597 NF1 neurofibromin 1 17 26446120, 26446120 AK024873 17q11.2 Hs.113577 204

osteoblast differentiation

metanephros development

response to hypoxia

liver development

negative regulation of endothelial cell proliferation

regulation of cell-matrix adhesion

Ras GTPase activator activity

protein binding

intracellular

nucleus

cytoplasm

signal transduction

Ras protein signal transduction

negative regulation of neuroblast proliferation

brain development

peripheral nervous system development

heart development

visual learning

phosphoinositide 3-kinase cascade

spinal cord development

forebrain astrocyte development

cerebral cortex development

myelination in the peripheral nervous system

actin cytoskeleton organization

collagen fibril organization

adrenal gland development

negative regulation of cell migration

axon

dendrite

positive regulation of Ras GTPase activity

wound healing

negative regulation of transcription factor import into nucleus

negative regulation of MAP kinase activity

negative regulation of MAPKKK cascade

pigmentation

positive regulation of neuron apoptosis

regulation of blood vessel endothelial cell migration

regulation of bone resorption

regulation of glial cell differentiation

positive regulation of adenylate cyclase activity

regulation of angiogenesis

sympathetic nervous system development

camera-type eye morphogenesis

negative regulation of oligodendrocyte differentiation

smooth muscle tissue development

artery morphogenesis

forebrain morphogenesis

cognition

regulation of small GTPase mediated signal transduction

MAPK signaling pathway

226380_at 0.379 6.509 2.831 1.252e-02 0.429 -2.747 PTPN21 protein tyrosine phosphatase, non-receptor type 21 14 -88001874 N21442 14q31.3 Hs.437040 10

protein tyrosine phosphatase activity

binding

cytoplasm

cytoskeleton

protein amino acid dephosphorylation

hydrolase activity

 
1556536_at -0.351 3.835 -3.690 2.140e-03 0.276 -1.245 hCG_2044152 hCG2044152 2   BC040292 2q33.1 Hs.623895 1    
213005_s_at 0.478 8.042 4.258 6.675e-04 0.211 -0.260 KANK1 KN motif and ankyrin repeat domains 1 9 494702, 696895 D79994 9p24.3 Hs.306764 14

cytoplasm

 
235146_at TMCC3 transmembrane and coiled-coil domain family 3 12 -93485030 N51717 12q22 Hs.370410 5

membrane

integral to membrane

 
203269_at 0.337 8.020 3.461 3.430e-03 0.308 -1.646 NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 8 -59658619, -59658619 NM_003580 8q12-q13 Hs.372000 8

receptor signaling protein activity

soluble fraction

cytoplasm

ceramide metabolic process

signal transduction

 
212510_at -0.504 10.561 -3.746 1.906e-03 0.273 -1.147 GPD1L glycerol-3-phosphate dehydrogenase 1-like 3 32123147 AA135522 3p22.3 Hs.82432 5

glycerol-3-phosphate dehydrogenase (NAD+) activity

binding

cytoplasm

carbohydrate metabolic process

glycerol-3-phosphate dehydrogenase complex

protein homodimerization activity

glycerol-3-phosphate catabolic process

NAD or NADH binding

oxidation reduction

Glycerophospholipid metabolism

228702_at 0.643 7.814 2.210 4.281e-02 0.576 -3.776 FLJ43663 hypothetical LOC378805 7 -130279458, -130279458 AL569506 7q32.3 Hs.150556 Hs.649308 2    
36030_at 0.484 6.822 2.588 2.042e-02 0.495 -3.159 IFFO1 intermediate filament family orphan 1 12 -6518954, -6518954 AL080214 12p13.3 Hs.15243 7

intermediate filament

 
219284_at -0.879 7.040 -4.254 6.732e-04 0.211 -0.267 HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 3 -123941535 NM_024610 3q21.1 Hs.29169 5

cytoplasm

 
227257_s_at C10orf46 chromosome 10 open reading frame 46 10 -120430483 AW973842 10q26.11 Hs.719193 4

ubiquitin-dependent protein catabolic process

cullin-RING ubiquitin ligase complex

ubiquitin protein ligase binding

 
221511_x_at 0.486 7.859 3.862 1.499e-03 0.251 -0.943 CCPG1 cell cycle progression 1 15 -53434729, -53434729 AB033080 15q21.1 Hs.285051 5

cell cycle

membrane

integral to membrane

 
238890_at PSMG1 proteasome (prosome, macropain) assembly chaperone 1 21 -39469253 AI791303 21q22.3 Hs.473838 12

protein binding

cytoplasm

endoplasmic reticulum

proteasome assembly

 
222423_at 0.291 7.461 2.429 2.798e-02 0.529 -3.423 NDFIP1 Nedd4 family interacting protein 1 5 141468507 H05010 5q31.3 Hs.653510 Hs.9788 11

signal transducer activity

protein binding

Golgi apparatus

cellular iron ion homeostasis

negative regulation of gene expression

membrane

integral to membrane

positive regulation of protein ubiquitination

negative regulation of transporter activity

positive regulation of I-kappaB kinase/NF-kappaB cascade

perinuclear region of cytoplasm

negative regulation of protein transport

 
225032_at 0.716 8.203 4.245 6.858e-04 0.211 -0.283 FNDC3B fibronectin type III domain containing 3B 3 173240111, 173241037 AI141784 3q26.31 Hs.159430 9

endoplasmic reticulum

membrane

integral to membrane

 
208817_at 0.413 7.854 2.457 2.647e-02 0.522 -3.377 COMT catechol-O-methyltransferase 22 18309262, 18318459, 18319044, 18330069 BC000419 22q11.21 22q11.21-q11.23 Hs.370408 Hs.704514 Hs.713616 742

magnesium ion binding

protein binding

soluble fraction

cytoplasm

microsome

cytosol

plasma membrane

catecholamine metabolic process

integral to membrane

catechol O-methyltransferase activity

catechol O-methyltransferase activity

transferase activity

neurotransmitter catabolic process

dopamine catabolic process

Tyrosine metabolism

Betalain biosynthesis

Metabolic pathways

225985_at 0.329 4.297 3.610 2.520e-03 0.287 -1.384 PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 5 -40795237 AI935917 5p12 Hs.43322 68

nucleotide binding

activation of MAPK activity

magnesium ion binding

response to hypoxia

protein serine/threonine kinase activity

cAMP-dependent protein kinase activity

protein binding

ATP binding

intracellular

glucose metabolic process

fatty acid biosynthetic process

signal transduction

transferase activity

fatty acid oxidation

positive regulation of cholesterol biosynthetic process

positive regulation of anti-apoptosis

negative regulation of glucosylceramide biosynthetic process

Regulation of autophagy

mTOR signaling pathway

Insulin signaling pathway

Adipocytokine signaling pathway

Hypertrophic cardiomyopathy (HCM)

203544_s_at 0.361 7.175 2.457 2.648e-02 0.522 -3.378 STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 10 17726129 NM_003473 10p14-p13 Hs.441498 30

SH3/SH2 adaptor activity

protein binding

cytoplasm

endosome

cytosol

intracellular protein transport

signal transduction

membrane

Endocytosis

Jak-STAT signaling pathway

228555_at 0.409 6.532 2.854 1.194e-02 0.426 -2.706 CAMK2D calcium/calmodulin-dependent protein kinase II delta 4 -114597792, -114591638 AA029441 4q26 Hs.144114 29

G1/S transition of mitotic cell cycle

nucleotide binding

regulation of cell growth

calmodulin-dependent protein kinase activity

calmodulin binding

ATP binding

nucleus

cytoplasm

calcium- and calmodulin-dependent protein kinase complex

calcium ion transport

transferase activity

T-tubule

protein amino acid autophosphorylation

cardiac muscle contraction

ErbB signaling pathway

Calcium signaling pathway

Wnt signaling pathway

Long-term potentiation

Neurotrophin signaling pathway

Olfactory transduction

GnRH signaling pathway

Melanogenesis

Glioma

212877_at 0.618 7.090 3.931 1.301e-03 0.242 -0.823 KLC1 kinesin light chain 1 14 103165277, 103165277 AA284075 14q32.3 Hs.20107 Hs.657678 31

microtubule motor activity

protein binding

cytoplasm

cytosol

kinesin complex

microtubule

axon cargo transport

axon

cytoplasmic vesicle

ciliary rootlet

membrane-bounded organelle

 
221753_at SSH1 slingshot homolog 1 (Drosophila) 12 -107709824, -107709824, -107700595 AI651213 12q24.11 Hs.199763 23

cell morphogenesis

actin binding

protein tyrosine phosphatase activity

protein binding

cytoplasm

cytoskeleton

plasma membrane

protein amino acid dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

hydrolase activity

lamellipodium

actin cytoskeleton organization

Regulation of actin cytoskeleton

238034_at 0.333 6.690 2.364 3.178e-02 0.544 -3.530 CANX calnexin 5 179058535 AI890021 5q35 Hs.699155 90

calcium ion binding

sugar binding

endoplasmic reticulum

protein folding

protein secretion

membrane

integral to membrane

melanosome

unfolded protein binding

Antigen processing and presentation

225300_at 0.675 6.369 4.445 4.570e-04 0.193 0.057 C15orf23 chromosome 15 open reading frame 23 15 38462213 BF792864 15q15.1 Hs.525796 6

protein binding

nucleus

 
220123_at 0.841 3.457 3.226 5.576e-03 0.354 -2.059 SLC35F5 solute carrier family 35, member F5 2 -114188402 NM_025181 2q14.1 Hs.632527 2

transport

membrane

integral to membrane

 
226922_at RANBP2 RAN binding protein 2 2 108702368 BF215302 2q12.3 Hs.199561 Hs.715056 61

peptidyl-prolyl cis-trans isomerase activity

protein binding

intracellular

nucleus

nuclear pore

cytosol

protein folding

protein import into nucleus

zinc ion binding

Ran GTPase binding

protein transport

isomerase activity

modification-dependent protein catabolic process

metal ion binding

intracellular transport

mRNA transport

intracellular protein transmembrane transport

 
217996_at 0.831 5.076 3.526 3.002e-03 0.300 -1.532 PHLDA1 pleckstrin homology-like domain, family A, member 1 12 -74705493 AA576961 12q15 Hs.602085 15

protein binding

nucleus

nucleolus

cytoplasm

apoptosis

membrane

cytoplasmic vesicle membrane

cytoplasmic vesicle

FasL biosynthetic process

 
200999_s_at 0.590 7.516 3.296 4.824e-03 0.339 -1.936 CKAP4 cytoskeleton-associated protein 4 12 -105155789 NM_006825 12q23.3 Hs.714862 Hs.74368 22

membrane fraction

endoplasmic reticulum

membrane

integral to membrane

 
217403_s_at 0.802 3.202 7.149 3.088e-06 0.039 4.013 ZNF227 zinc finger protein 227 19 49408530 AC074331   Hs.371335 6

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
217761_at ADI1 acireductone dioxygenase 1 2 -3480696 NM_018269 2p25.3 Hs.502773 13

protein binding

nucleus

cytoplasm

plasma membrane

cellular amino acid biosynthetic process

methionine biosynthetic process

nickel ion binding

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

methionine salvage

metal ion binding

oxidation reduction

Cysteine and methionine metabolism

Metabolic pathways

225999_at 0.523 5.149 2.943 9.950e-03 0.412 -2.552 RIMKLB ribosomal modification protein rimK-like family member B 12 8741784 AI743612 12p13.31 Hs.504670 4

nucleotide binding

catalytic activity

ATP binding

protein modification process

manganese ion binding

metal ion binding

 
229799_s_at 0.961 4.985 3.497 3.184e-03 0.305 -1.583 NCAM1 neural cell adhesion molecule 1 11 112337204, 112337204 AI569787 11q23.1 Hs.503878 120

protein binding

extracellular region

plasma membrane

cell adhesion

integral to membrane

anchored to membrane

Cell adhesion molecules (CAMs)

Prion diseases

218033_s_at 0.716 5.345 2.958 9.647e-03 0.406 -2.526 SNN stannin 16 11669801 NM_003498 16p13 Hs.700592 11

response to stress

response to abiotic stimulus

membrane

integral to membrane

 
241389_at CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 1 152806880 BE261002 1q21.3 Hs.2306 59

conditioned taste aversion

response to hypoxia

nicotinic acetylcholine-activated cation-selective channel activity

ion channel activity

extracellular ligand-gated ion channel activity

protein binding

plasma membrane

nicotinic acetylcholine-gated receptor-channel complex

ion transport

calcium ion transport

smooth muscle contraction

signal transduction

synaptic transmission, cholinergic

visual perception

sensory perception of sound

memory

locomotory behavior

visual learning

external side of plasma membrane

acetylcholine receptor activity

integral to membrane

sensory perception of pain

vestibulocochlear nerve development

optic nerve morphogenesis

lateral geniculate nucleus development

central nervous system projection neuron axonogenesis

cell junction

positive regulation of B cell proliferation

positive regulation of synaptic transmission, dopaminergic

positive regulation of dopamine secretion

behavioral response to nicotine

social behavior

regulation of dopamine metabolic process

B cell activation

response to cocaine

regulation of circadian sleep/wake cycle, REM sleep

regulation of circadian sleep/wake cycle, non-REM sleep

synapse

postsynaptic membrane

response to ethanol

negative regulation of action potential

regulation of dendrite morphogenesis

cognition

membrane depolarization

regulation of synaptogenesis

synaptic transmission involved in micturition

 
219887_at -0.266 4.457 -3.436 3.612e-03 0.314 -1.690 CCDC87 coiled-coil domain containing 87 11 -66114215 NM_018219 11q13.2 Hs.121072 3    
227534_at 0.798 6.441 4.235 7.000e-04 0.211 -0.300 C9orf21 chromosome 9 open reading frame 21 9 -98443353 AI655189 9q22.32 Hs.44640 4    
204736_s_at 0.517 4.947 4.446 4.561e-04 0.193 0.059 CSPG4 chondroitin sulfate proteoglycan 4 15 -73753717 NM_001897 15q24.2 Hs.513044 34

angiogenesis

signal transducer activity

receptor signaling protein tyrosine phosphatase signaling protein activity

protein binding

plasma membrane

integral to plasma membrane

signal transduction

multicellular organismal development

receptor signaling protein tyrosine kinase signaling protein activity

cell surface

cell differentiation

cell projection

tissue remodeling

 
243409_at -0.258 5.675 -2.919 1.045e-02 0.418 -2.593 FOXL1 forkhead box L1 16 85169615 AI005407 16q24 Hs.533830 7

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

DNA bending activity

sequence-specific DNA binding

 
221935_s_at 0.449 5.848 2.145 4.852e-02 0.590 -3.879 C3orf64 chromosome 3 open reading frame 64 3 -69107057 AK023140 3p14.1 Hs.518059 2

extracellular region

endoplasmic reticulum

transferase activity, transferring glycosyl groups

 
225525_at 1.019 7.458 2.759 1.447e-02 0.447 -2.869 KIAA1671 KIAA1671 22 23753940 AB051458 22q11.23 Hs.419171 4    
220984_s_at 0.540 5.658 5.123 1.196e-04 0.162 1.165 SLCO5A1 solute carrier organic anion transporter family, member 5A1 8 -70747123, -70747123, -70747123 NM_030958 8q13.3 Hs.152460 Hs.443609 3

transporter activity

transport

membrane

integral to membrane

 
221815_at 0.945 5.603 3.717 2.024e-03 0.273 -1.197 ABHD2 abhydrolase domain containing 2 15 87432384 BE671816 15q26.1 Hs.122337 Hs.705984 10

molecular_function

carboxylesterase activity

biological_process

response to wounding

membrane

integral to membrane

hydrolase activity

negative regulation of cell migration

 
219543_at 0.906 4.884 4.216 7.269e-04 0.211 -0.332 PBLD phenazine biosynthesis-like protein domain containing 10 -69714843, -69712422 NM_022129 10pter-q25.3 Hs.198158 7

cellular_component

biological_process

biosynthetic process

isomerase activity

 
232306_at -0.249 3.172 -2.922 1.040e-02 0.418 -2.590 CDH26 cadherin-like 26 20 57966876, 58004823 BG289314 20q13.2-q13.33 Hs.54973 4

calcium ion binding

protein binding

plasma membrane

cell adhesion

homophilic cell adhesion

integral to membrane

 
203038_at 0.528 6.589 4.587 3.437e-04 0.179 0.295 PTPRK protein tyrosine phosphatase, receptor type, K 6 -128331617, -128331617 NM_002844 6q22.2-q22.3 Hs.155919 20

receptor activity

transmembrane receptor protein tyrosine phosphatase activity

plasma membrane

integral to plasma membrane

cell-cell junction

adherens junction

protein amino acid dephosphorylation

cell adhesion

signal transduction

transforming growth factor beta receptor signaling pathway

beta-catenin binding

cell surface

negative regulation of keratinocyte proliferation

negative regulation of transcription

hydrolase activity

protein kinase binding

negative regulation of cell migration

leading edge membrane

protein localization at cell surface

cellular response to reactive oxygen species

cellular response to UV

gamma-catenin binding

negative regulation of cell cycle

focal adhesion formation

 
1553954_at ALG14 asparagine-linked glycosylation 14 homolog (S. cerevisiae) 1 -95220866 BU682208 1p21.3 Hs.408927 5

endoplasmic reticulum

membrane

integral to membrane

N-Glycan biosynthesis

Metabolic pathways

213248_at LOC730101 hypothetical LOC730101 6 52637157 AL577024 6p12.2 Hs.7921 2    
208456_s_at 0.756 6.926 4.106 9.107e-04 0.220 -0.521 RRAS2 related RAS viral (r-ras) oncogene homolog 2 11 -14256041, -14256041 NM_012250 11p15.2 Hs.502004 25

nucleotide binding

GTPase activity

protein binding

GTP binding

intracellular

endoplasmic reticulum

plasma membrane

Ras protein signal transduction

cellular process

positive regulation of cell migration

MAPK signaling pathway

Tight junction

Regulation of actin cytoskeleton

221764_at C19orf22 chromosome 19 open reading frame 22 19 -847502 AL574186 19p13.3 Hs.557655 2

nucleic acid binding

nucleus

 
226649_at PANK1 pantothenate kinase 1 10 -91332728, -91332728 AI373299 10q23.31 Hs.715502 10

nucleotide binding

pantothenate kinase activity

pantothenate kinase activity

ATP binding

cytoplasm

cytosol

coenzyme A biosynthetic process

transferase activity

Pantothenate and CoA biosynthesis

Metabolic pathways

241459_at LIMCH1 LIM and calponin homology domains 1 4 41057560, 41309675 AI494113 4p13 Hs.335163 10

actin binding

zinc ion binding

actomyosin structure organization

metal ion binding

 
202985_s_at 0.407 6.914 3.555 2.825e-03 0.294 -1.481 BAG5 BCL2-associated athanogene 5 14 -103092641, -103092641, -103092641 NM_004873 14q32.33 Hs.5443 10

protein binding

protein folding

apoptosis

 
208814_at 0.533 7.388 2.828 1.259e-02 0.429 -2.751 HSPA4 heat shock 70kDa protein 4 5 132415560 AA043348 5q31.1-q31.2 Hs.90093 108

nucleotide binding

ATP binding

nucleus

cytoplasm

response to unfolded protein

cellular chaperone-mediated protein complex assembly

mitochondrial outer membrane translocase complex assembly

Antigen processing and presentation

226538_at 0.594 7.174 3.204 5.835e-03 0.357 -2.098 MAN2A1 mannosidase, alpha, class 2A, member 1 5 109053054 AV700323 5q21-q22 Hs.432822 29

Golgi membrane

in utero embryonic development

liver development

alpha-mannosidase activity

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

Golgi apparatus

carbohydrate metabolic process

mannose metabolic process

N-glycan processing

mitochondrion organization

vacuole organization

respiratory gaseous exchange

metabolic process

zinc ion binding

membrane

integral to membrane

hydrolase activity, hydrolyzing N-glycosyl compounds

carbohydrate binding

metal ion binding

lung alveolus development

N-Glycan biosynthesis

Metabolic pathways

220907_at GPR110 G protein-coupled receptor 110 6 -47095580, -47075771 NM_025048 6p12.3 Hs.256897 11

G-protein coupled receptor activity

G-protein coupled receptor activity

plasma membrane

neuropeptide signaling pathway

integral to membrane

integral to membrane

 
224339_s_at 0.924 6.257 3.903 1.378e-03 0.245 -0.871 ANGPTL1 angiopoietin-like 1 1 -177085292 AB056476 1q25.2 Hs.591474 19

receptor binding

extracellular region

extracellular space

signal transduction

 
1569796_s_at ATRNL1 attractin-like 1 10 116843113 BC035157 10q26 Hs.501127 3

binding

sugar binding

membrane

integral to membrane

 
225043_at 0.702 7.196 3.676 2.201e-03 0.276 -1.269 SLC15A4 solute carrier family 15, member 4 12 -127843692 AW304786 12q24.32-q24.33 Hs.507260 Hs.699387 6

transporter activity

oligopeptide transport

protein transport

symporter activity

membrane

integral to membrane

 
233480_at 0.516 3.492 3.687 2.151e-03 0.276 -1.249 TMEM43 transmembrane protein 43 3 14141440 AK026869 3p25.1 Hs.517817 18

nucleus

endoplasmic reticulum

Golgi apparatus

membrane

integral to membrane

 
221840_at PTPRE protein tyrosine phosphatase, receptor type, E 10 129595314, 129735802 AA775177 10q26 Hs.127022 33

transmembrane receptor protein tyrosine phosphatase activity

protein binding

cytoplasm

plasma membrane

protein amino acid phosphorylation

protein amino acid dephosphorylation

integral to membrane

hydrolase activity

 
202370_s_at 0.521 7.815 3.393 3.943e-03 0.321 -1.765 CBFB core-binding factor, beta subunit 16 65620550 NM_001755 16q22.1 Hs.460988 39

osteoblast differentiation

transcription factor activity

RNA polymerase II transcription factor activity

transcription coactivator activity

protein binding

nucleus

lymphocyte differentiation

myeloid cell differentiation

positive regulation of transcription from RNA polymerase II promoter

cell maturation

definitive hemopoiesis

 
204589_at 0.670 7.466 3.512 3.086e-03 0.302 -1.556 NUAK1 NUAK family, SNF1-like kinase, 1 12 -104981254 NM_014840 12q23.3 Hs.719171 13

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

protein amino acid phosphorylation

transferase activity

 
218567_x_at 0.483 6.024 3.464 3.407e-03 0.308 -1.640 DPP3 dipeptidyl-peptidase 3 11 66004455 NM_005700 11q12-q13.1 Hs.502914 29

aminopeptidase activity

cytoplasm

proteolysis

peptidase activity

metallopeptidase activity

dipeptidyl-peptidase activity

zinc ion binding

metal ion binding

 
226178_at 0.452 5.352 2.727 1.544e-02 0.458 -2.924 SOCS4 suppressor of cytokine signaling 4 14 54563593 BF446961 14q22.2-q22.3 Hs.708344 7

protein binding

intracellular signaling cascade

negative regulation of signal transduction

modification-dependent protein catabolic process

regulation of growth

Jak-STAT signaling pathway

Insulin signaling pathway

Type II diabetes mellitus

212678_at 0.309 5.639 2.844 1.218e-02 0.426 -2.723 NF1 neurofibromin 1 17 26446120, 26446120 AW054826 17q11.2 Hs.113577 204

osteoblast differentiation

metanephros development

response to hypoxia

liver development

negative regulation of endothelial cell proliferation

regulation of cell-matrix adhesion

Ras GTPase activator activity

protein binding

intracellular

nucleus

cytoplasm

signal transduction

Ras protein signal transduction

negative regulation of neuroblast proliferation

brain development

peripheral nervous system development

heart development

visual learning

phosphoinositide 3-kinase cascade

spinal cord development

forebrain astrocyte development

cerebral cortex development

myelination in the peripheral nervous system

actin cytoskeleton organization

collagen fibril organization

adrenal gland development

negative regulation of cell migration

axon

dendrite

positive regulation of Ras GTPase activity

wound healing

negative regulation of transcription factor import into nucleus

negative regulation of MAP kinase activity

negative regulation of MAPKKK cascade

pigmentation

positive regulation of neuron apoptosis

regulation of blood vessel endothelial cell migration

regulation of bone resorption

regulation of glial cell differentiation

positive regulation of adenylate cyclase activity

regulation of angiogenesis

sympathetic nervous system development

camera-type eye morphogenesis

negative regulation of oligodendrocyte differentiation

smooth muscle tissue development

artery morphogenesis

forebrain morphogenesis

cognition

regulation of small GTPase mediated signal transduction

MAPK signaling pathway

238606_at ZNF747 zinc finger protein 747 16 -30450279 AV698217 16p11.2 Hs.592032 3

nucleic acid binding

intracellular

regulation of transcription, DNA-dependent

 
227025_at PPHLN1 periphilin 1 12 41006213, 41006213, 41006213, 41006213 BG284497 12q12 Hs.444157 13

nucleus

cytoplasm

keratinization

 
212915_at -0.865 9.177 -3.238 5.430e-03 0.352 -2.037 PDZRN3 PDZ domain containing ring finger 3 3 -73514341 AL569804 3p13 Hs.719126 9

protein binding

zinc ion binding

metal ion binding

 
228525_at LRP3 low density lipoprotein receptor-related protein 3 19 38377438 AL583533 19q13.11 Hs.515340 Hs.715569 9

receptor activity

coated pit

receptor-mediated endocytosis

membrane

integral to membrane

 
214455_at 1.058 3.861 2.867 1.163e-02 0.426 -2.684 HIST1H2BC histone cluster 1, H2bc 6 -26231673 NM_003526 6p21.3 Hs.658713 10

nucleosome

DNA binding

protein binding

nucleus

chromosome

nucleosome assembly

defense response to bacterium

Systemic lupus erythematosus

222547_at 0.588 5.098 3.521 3.029e-03 0.300 -1.540 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2 101680919 AL561281 2q11.2-q12 Hs.719073 22

nucleotide binding

protein serine/threonine kinase activity

small GTPase regulator activity

ATP binding

cellular_component

protein amino acid phosphorylation

response to stress

protein kinase cascade

transferase activity

MAPK signaling pathway

1565254_s_at 0.314 4.196 3.868 1.483e-03 0.250 -0.933 ELL elongation factor RNA polymerase II 19 -18414473 AF272374 19p13.1 Hs.515260 26

protein binding

nucleus

nucleoplasm

RNA elongation from RNA polymerase II promoter

transcription elongation factor complex

positive transcription elongation factor activity

Cajal body

nuclear speck

RNA polymerase II transcription elongation factor activity

regulation of transcription

 
225972_at 0.864 6.355 3.326 4.534e-03 0.332 -1.883 TMEM64 transmembrane protein 64 8 -91703398 AA524005 8q21.3 Hs.567759 2

membrane

integral to membrane

 
225886_at 0.523 6.944 4.456 4.476e-04 0.193 0.075 DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 17 -59924835 AA156797 17q21 Hs.279806 50

nucleotide binding

RNA binding

RNA helicase activity

protein binding

ATP binding

nucleus

spliceosomal complex

nucleolus

mRNA processing

ATP-dependent helicase activity

RNA splicing

cell growth

hydrolase activity

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

 
239093_at 0.566 4.587 3.312 4.665e-03 0.336 -1.908 DHDPSL dihydrodipicolinate synthase-like, mitochondrial 10 99334091 BG165743 10q24.2 Hs.180346 4

mitochondrion

metabolic process

lyase activity

 
205842_s_at 0.784 5.011 3.166 6.305e-03 0.363 -2.164 JAK2 Janus kinase 2 9 4975244 AF001362 9p24 Hs.656213 588

nucleotide binding

non-membrane spanning protein tyrosine kinase activity

Janus kinase activity

receptor binding

growth hormone receptor binding

interleukin-12 receptor binding

ATP binding

nucleus

cytoplasm

cytoskeleton

caveola

apoptosis

cell motion

enzyme linked receptor protein signaling pathway

tyrosine phosphorylation of STAT protein

STAT protein nuclear translocation

mesoderm development

negative regulation of cell proliferation

positive regulation of phosphoinositide 3-kinase cascade

membrane

transferase activity

myeloid cell differentiation

SH2 domain binding

positive regulation of tyrosine phosphorylation of Stat3 protein

positive regulation of tyrosine phosphorylation of Stat5 protein

negative regulation of DNA binding

response to antibiotic

positive regulation of peptidyl-tyrosine phosphorylation

JAK-STAT cascade involved in growth hormone signaling pathway

positive regulation of growth hormone receptor signaling pathway

Chemokine signaling pathway

Jak-STAT signaling pathway

Adipocytokine signaling pathway

219225_at 0.644 5.549 5.302 8.459e-05 0.162 1.447 PGBD5 piggyBac transposable element derived 5 1 -228524014 NM_024554 1q42.13 Hs.520463 3

membrane

integral to membrane

 
226632_at CYGB cytoglobin 17 -72035034 AL513673 17q25.3 Hs.95120 28

peroxidase activity

oxygen transporter activity

cytoplasm

transport

response to oxidative stress

oxygen transport

oxygen binding

heme binding

neuron projection

cell soma

metal ion binding

 
229840_at -0.342 5.819 -3.644 2.349e-03 0.284 -1.324 IQSEC2 IQ motif and Sec7 domain 2 X -53312230, -53278789, -53278782 AW026036 Xp11.22 Hs.496138 10

ARF guanyl-nucleotide exchange factor activity

intracellular

cytoplasm

regulation of ARF protein signal transduction

Endocytosis

229310_at 0.802 5.992 2.792 1.354e-02 0.438 -2.813 KLHL29 kelch-like 29 (Drosophila) 2   BE465475 2p24.1 Hs.130593 5

protein binding

 
209804_at 0.695 5.084 3.081 7.501e-03 0.376 -2.312 DCLRE1A DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) 10 -115584473 D42045 10q25.1 Hs.1560 14

nucleus

nucleotide-excision repair

response to DNA damage stimulus

cell cycle

mitosis

cell division

 
218521_s_at 0.744 6.304 2.779 1.391e-02 0.442 -2.836 UBE2W ubiquitin-conjugating enzyme E2W (putative) 8 -74865393 NM_018299 8q21.11 Hs.597486 7

nucleotide binding

ubiquitin-protein ligase activity

ATP binding

ligase activity

modification-dependent protein catabolic process

post-translational protein modification

regulation of protein metabolic process

Ubiquitin mediated proteolysis

209825_s_at 0.644 6.658 3.902 1.382e-03 0.245 -0.874 UCK2 uridine-cytidine kinase 2 1 164063513 BC002906 1q23 Hs.458360 22

nucleotide binding

molecular_function

uridine kinase activity

ATP binding

cellular_component

cytosol

metabolic process

kinase activity

transferase activity

phosphotransferase activity, alcohol group as acceptor

Pyrimidine metabolism

Drug metabolism - other enzymes

Metabolic pathways

213034_at QSK serine/threonine-protein kinase QSK 11 -116219327 AB023216 11q23.3 Hs.167451 14

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

protein amino acid phosphorylation

transferase activity

 
212442_s_at LASS6 LAG1 homolog, ceramide synthase 6 2 169021080 BG289001 2q24.3 Hs.506829 Hs.718403 5

transcription factor activity

nucleus

endoplasmic reticulum

regulation of transcription, DNA-dependent

lipid biosynthetic process

membrane

integral to membrane

sphingolipid biosynthetic process

sequence-specific DNA binding

ceramide biosynthetic process

sphingosine N-acyltransferase activity

 
1554801_at -0.380 3.306 -3.834 1.590e-03 0.258 -0.992 C5orf40 chromosome 5 open reading frame 40 5 -156701184 BC022570 5q33.3 Hs.437066 3

membrane

integral to membrane

 
222942_s_at 1.031 5.655 4.188 7.700e-04 0.211 -0.380 TIAM2 T-cell lymphoma invasion and metastasis 2 6 155453114, 155579788 AI094945 6q25.2 Hs.586279 5

receptor signaling protein activity

guanyl-nucleotide exchange factor activity

Rho guanyl-nucleotide exchange factor activity

protein binding

intracellular

cytoplasm

intracellular signaling cascade

lamellipodium

filopodium

growth cone

regulation of Rho protein signal transduction

Chemokine signaling pathway

Regulation of actin cytoskeleton

222731_at ZDHHC2 zinc finger, DHHC-type containing 2 8 17058206 AK001608 8p21.3-p22 Hs.443852 8

zinc ion binding

membrane

integral to membrane

palmitoyltransferase activity

transferase activity

protein palmitoylation

metal ion binding

 
215071_s_at 0.780 7.430 3.873 1.466e-03 0.250 -0.924 HIST1H2AC histone cluster 1, H2ac 6 26232351 AL353759 6p21.3 Hs.699831 19

nucleosome

DNA binding

nucleus

chromosome

nucleosome assembly

Systemic lupus erythematosus

226184_at FMNL2 formin-like 2 2 152899996 AI123567 2q23.3 Hs.654630 9

actin binding

cytoplasm

cellular component organization

Rho GTPase binding

actin cytoskeleton organization

 
205173_x_at 0.329 6.740 2.331 3.388e-02 0.552 -3.583 CD58 CD58 molecule 1 -116862845, -116858679 NM_001779 1p13 Hs.34341 38

protein binding

plasma membrane

integral to plasma membrane

cell-cell adhesion

anchored to membrane

Cell adhesion molecules (CAMs)

221495_s_at 0.324 7.674 2.898 1.091e-02 0.423 -2.630 TCF25 transcription factor 25 (basic helix-loop-helix) 16 88467494 AF322111 16q24.3 Hs.415342 9

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

protein binding

nucleus

heart development

regulation of transcription

 
232604_at 0.588 5.571 4.601 3.342e-04 0.179 0.318 ZNF541 zinc finger protein 541 19 -52715759 AL136846 19q13.33 Hs.14161 3

DNA binding

intracellular

nucleus

multicellular organismal development

spermatogenesis

zinc ion binding

cell differentiation

regulation of transcription

metal ion binding

 
215675_at -0.307 5.001 -2.697 1.642e-02 0.464 -2.976 TEF thyrotrophic embryonic factor 22 40093337, 40107908 AB051442 22q13 22q13.2 Hs.181159 14

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

regulation of transcription from RNA polymerase II promoter

sequence-specific DNA binding

protein dimerization activity

rhythmic process

 
215804_at -0.464 4.861 -4.359 5.440e-04 0.207 -0.088 EPHA1 EPH receptor A1 7 -142798327 Z27409 7q34 Hs.89839 30

nucleotide binding

receptor activity

ephrin receptor activity

ATP binding

integral to plasma membrane

protein amino acid phosphorylation

signal transduction

transmembrane receptor protein tyrosine kinase signaling pathway

membrane

transferase activity

Axon guidance

223886_s_at RNF146 ring finger protein 146 6 127629712 AL136829 6q22.1-q22.33 Hs.267120 12

protein binding

zinc ion binding

metal ion binding

 
201594_s_at 0.324 7.518 3.446 3.541e-03 0.311 -1.673 PPP4R1 protein phosphatase 4, regulatory subunit 1 18 -9536791 NM_005134 18p11.22 Hs.719096 11

protein binding

soluble fraction

signal transduction

protein phosphatase type 4 regulator activity

 
228793_at JMJD1C jumonji domain containing 1C 10 -64596993, -64596993 BF002296 10q21.3 Hs.413416 10

iron ion binding

protein binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

oxidoreductase activity

chromatin modification

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

metal ion binding

thyroid hormone receptor binding

oxidation reduction

 
216048_s_at 0.577 4.799 4.122 8.805e-04 0.219 -0.493 RHOBTB3 Rho-related BTB domain containing 3 5 95092605 AK023621 5q15 Hs.445030 13

protein binding

ATP binding

ATPase activity

Rab GTPase binding

retrograde transport, endosome to Golgi

 
228279_s_at TNK2 tyrosine kinase, non-receptor, 2 3 -197074632, -197074632 BE676245 3q29 Hs.518513 37

nucleotide binding

magnesium ion binding

non-membrane spanning protein tyrosine kinase activity

GTPase inhibitor activity

protein binding

ATP binding

plasma membrane

protein amino acid phosphorylation

small GTPase mediated signal transduction

transferase activity

positive regulation of peptidyl-tyrosine phosphorylation

 
242157_at 1.049 4.464 5.068 1.330e-04 0.169 1.078 CHD9 chromodomain helicase DNA binding protein 9 16 51646445 AW469037 16q12.2 Hs.59159 Hs.622347 10

nucleotide binding

chromatin

DNA binding

chromatin binding

helicase activity

protein binding

ATP binding

nucleus

cytoplasm

chromatin assembly or disassembly

chromatin modification

hydrolase activity

regulation of transcription

 
201544_x_at 0.505 9.087 4.804 2.235e-04 0.172 0.652 PABPN1 poly(A) binding protein, nuclear 1 14 22859236 BF675004 14q11.2-q13 Hs.707712 42

nucleotide binding

nuclear mRNA splicing, via spliceosome

RNA binding

protein binding

nucleus

nucleoplasm

nucleolus

cytoplasm

muscle contraction

poly(A)+ mRNA export from nucleus

 
212582_at 0.913 7.202 3.799 1.707e-03 0.267 -1.053 OSBPL8 oxysterol binding protein-like 8 12 -75269708 AL049923 12q14 Hs.430849 13

lipid transport

steroid metabolic process

 
224743_at 0.620 8.892 3.344 4.364e-03 0.328 -1.851 IMPAD1 inositol monophosphatase domain containing 1 8 -58033041 BF674724 8q12.1 Hs.716471 4

magnesium ion binding

inositol-1(or 4)-monophosphatase activity

membrane

integral to membrane

hydrolase activity

 
201155_s_at -0.309 9.746 -2.644 1.825e-02 0.480 -3.065 MFN2 mitofusin 2 1 11962824 NM_014874 1p36.22 Hs.376681 43

nucleotide binding

blastocyst formation

GTPase activity

protein binding

GTP binding

mitochondrion

cytosol

protein targeting to mitochondrion

mitochondrial membrane organization

cell cycle arrest

mitochondrial fusion

microtubule cytoskeleton

membrane

integral to membrane

hydrolase activity

intrinsic to mitochondrial outer membrane

negative regulation of Ras protein signal transduction

camera-type eye morphogenesis

negative regulation of smooth muscle cell proliferation

mitochondrion localization

 
219630_at 0.304 4.213 3.172 6.230e-03 0.362 -2.154 PDZK1IP1 PDZK1 interacting protein 1 1 -47421847 NM_005764 1p33 Hs.431099 16

membrane

integral to membrane

 
217759_at 0.349 6.964 4.073 9.739e-04 0.223 -0.578 TRIM44 tripartite motif-containing 44 11 35640928 BF431488 11p13 Hs.192103 10

intracellular

zinc ion binding

metal ion binding

 
214657_s_at 0.856 5.063 4.504 4.062e-04 0.192 0.156 NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding) 11 64946844, 64946844 AU134977 11q13.1 Hs.523789 Hs.648467 6    
216251_s_at 0.424 6.200 4.519 3.939e-04 0.192 0.181 TTLL12 tubulin tyrosine ligase-like family, member 12 22 -41892571 BF965437 22q13.31 Hs.517670 6

tubulin-tyrosine ligase activity

protein modification process

 
225962_at ZNRF1 zinc and ring finger 1 16 73590415 AI199541 16q23.1 Hs.427284 11

protein binding

lysosome

endosome

zinc ion binding

membrane

ligase activity

modification-dependent protein catabolic process

cell junction

cytoplasmic vesicle

synapse

metal ion binding

 
1555379_at FAM159A family with sequence similarity 159, member A 1 52871653 BC041608 1p32.3 Hs.424589 2

membrane

integral to membrane

 
36554_at 0.540 5.830 3.235 5.467e-03 0.352 -2.043 ASMTL acetylserotonin O-methyltransferase-like X, Y -1482031, -1482031 Y15521 Xp22.3 Yp11.3 Hs.533514 10

cellular_component

cytoplasm

acetylserotonin O-methyltransferase activity

melatonin biosynthetic process

 
239297_at C8orf79 chromosome 8 open reading frame 79 8 12847553, 12914143 BE932011 8p22 Hs.202521 5

metabolic process

methyltransferase activity

transferase activity

 
1560382_at -0.369 5.326 -4.360 5.430e-04 0.207 -0.087 GAB1 GRB2-associated binding protein 1 4 144477432 AK074381 4q31.21 Hs.618456 Hs.80720 69

SH3/SH2 adaptor activity

protein binding

cytosol

epidermal growth factor receptor signaling pathway

cell proliferation

insulin receptor signaling pathway

ErbB signaling pathway

Neurotrophin signaling pathway

Renal cell carcinoma

221733_s_at -0.356 4.038 -3.765 1.831e-03 0.270 -1.112 GPATCH4 G patch domain containing 4 1 -154830902 BE546897 1q22 Hs.193832 Hs.708599 3

nucleic acid binding

intracellular

 
212666_at 0.398 5.449 2.696 1.644e-02 0.464 -2.977 SMURF1 SMAD specific E3 ubiquitin protein ligase 1 7 -98462999 AB046845 7q22.1 Hs.189329 34

ubiquitin-protein ligase activity

protein binding

intracellular

cytoplasm

plasma membrane

protein modification process

protein export from nucleus

ectoderm development

ligase activity

acid-amino acid ligase activity

modification-dependent protein catabolic process

cell differentiation

negative regulation of ossification

negative regulation of BMP signaling pathway

ubiquitin-dependent SMAD protein catabolic process

positive regulation of protein ubiquitination

receptor catabolic process

protein localization at cell surface

protein ubiquitination during ubiquitin-dependent protein catabolic process

proteasomal ubiquitin-dependent protein catabolic process

activin binding

I-SMAD binding

R-SMAD binding

Ubiquitin mediated proteolysis

Endocytosis

TGF-beta signaling pathway

212610_at 0.355 10.103 2.216 4.234e-02 0.575 -3.767 PTPN11 protein tyrosine phosphatase, non-receptor type 11 12 111340918 U79291 12q24 Hs.506852 Hs.646231 326

non-membrane spanning protein tyrosine phosphatase activity

non-membrane spanning protein tyrosine phosphatase activity

protein binding

cytoplasm

cytosol

protein amino acid dephosphorylation

signal transduction

hydrolase activity

Jak-STAT signaling pathway

Natural killer cell mediated cytotoxicity

Leukocyte transendothelial migration

Neurotrophin signaling pathway

Adipocytokine signaling pathway

Epithelial cell signaling in Helicobacter pylori infection

Renal cell carcinoma

Chronic myeloid leukemia

218750_at 0.610 5.525 3.536 2.940e-03 0.298 -1.515 TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 11 -93108745 NM_024116 11q21 Hs.355750 6

DNA binding

protein binding

nucleus

regulation of transcription

 
212461_at 0.339 8.606 2.725 1.552e-02 0.458 -2.928 AZIN1 antizyme inhibitor 1 8 -103907711 BF793951 8q22.3 Hs.459106 10

catalytic activity

protein binding

polyamine biosynthetic process

ornithine decarboxylase inhibitor activity

ornithine decarboxylase activator activity

 
223805_at 0.512 8.468 2.860 1.180e-02 0.426 -2.696 OSBPL6 oxysterol binding protein-like 6 2 178767619, 178893216 AF323728 2q31-q32.1 Hs.318775 7

lipid transport

steroid metabolic process

 
1556190_s_at 0.538 3.310 4.320 5.887e-04 0.211 -0.154 PRNP prion protein 20 4614796, 4615156 AK056897 20p13 Hs.472010 Hs.610285 Hs.707152 Hs.714553 353

copper ion binding

cytoplasm

endoplasmic reticulum

Golgi apparatus

plasma membrane

cellular copper ion homeostasis

anti-apoptosis

response to oxidative stress

microtubule binding

metabolic process

extrinsic to membrane

anchored to membrane

identical protein binding

membrane raft

response to cadmium ion

response to copper ion

protein homooligomerization

Prion diseases

203183_s_at -0.243 4.668 -2.799 1.335e-02 0.435 -2.801 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 12 48765249 NM_003076 12q13-q14 Hs.79335 23

transcription coactivator activity

nucleus

nucleoplasm

nucleolus

regulation of transcription from RNA polymerase II promoter

SWI/SNF complex

chromatin remodeling complex

protein complex scaffold

chromatin-mediated maintenance of transcription

 
223681_s_at INADL InaD-like (Drosophila) 1 61980736 AB044807 1p31.3 Hs.478125 24

protein binding

cellular_component

plasma membrane

tight junction

intracellular signaling cascade

apical plasma membrane

cell junction

Tight junction

1566147_a_at -0.351 5.322 -2.880 1.133e-02 0.426 -2.662 LOC375010 ankyrin repeat domain 20 family, member A pseudogene 1   AK098337 1q21.1 Hs.672092 1    
220241_at 0.488 3.100 2.950 9.809e-03 0.409 -2.540 TMCO3 transmembrane and coiled-coil domains 3 13 113193308 NM_017905 13q34 Hs.317593 6

cation transport

antiporter activity

solute:hydrogen antiporter activity

membrane

integral to membrane

 
238727_at 0.762 3.259 3.972 1.197e-03 0.234 -0.752 LOC440934 hypothetical LOC440934 2   AA031832 2q36.1 Hs.715764 1    
208385_at -0.252 4.801 -2.210 4.285e-02 0.576 -3.777 NR2E3 nuclear receptor subfamily 2, group E, member 3 15 69889947, 69889947 NM_016346 15q22.32 Hs.187354 23

transcription factor activity

steroid hormone receptor activity

steroid binding

nucleus

regulation of transcription, DNA-dependent

transcription from RNA polymerase II promoter

signal transduction

visual perception

phototransduction

zinc ion binding

sequence-specific DNA binding

metal ion binding

response to stimulus

 
233918_at DCDC2B doublecortin domain containing 2B 1 32447281 AI924786 1p35.1 Hs.424588 1

intracellular signaling cascade

 
203699_s_at 0.604 3.922 4.268 6.547e-04 0.211 -0.244 DIO2 deiodinase, iodothyronine, type II 14 -79733621, -79733621 U53506 14q24.2-q24.3 Hs.202354 61

selenocysteine incorporation

thyroxine 5'-deiodinase activity

thyroid hormone generation

selenium binding

membrane

integral to membrane

thyroid hormone catabolic process

hormone biosynthetic process

oxidation reduction

 
211548_s_at 0.754 5.023 4.207 7.410e-04 0.211 -0.348 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 4 -175647902, -175647902 J05594 4q34-q35 Hs.596913 47

prostaglandin E receptor activity

binding

nucleus

nucleolus

cytoplasm

cytosol

lipid metabolic process

fatty acid metabolic process

prostaglandin metabolic process

transforming growth factor beta receptor signaling pathway

female pregnancy

parturition

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

oxidoreductase activity

lipoxygenase pathway

protein homodimerization activity

negative regulation of cell cycle

NAD or NADH binding

oxidation reduction

 
1563511_at 0.600 5.231 3.237 5.445e-03 0.352 -2.039 DKFZp451B082 hypothetical gene supported by AL831931 6   AL831931 6q26 Hs.444817      
221825_at 0.448 7.512 2.651 1.801e-02 0.476 -3.054 ANGEL2 angel homolog 2 (Drosophila) 1 -211232146 AU151793 1q32.3 Hs.157078 3    
224276_at 0.641 3.695 4.941 1.707e-04 0.171 0.874 ZNF33A zinc finger protein 33A 10 38339583 AF063599 10p11.2 Hs.435774 8

transcription factor activity

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
214152_at 0.427 7.299 3.073 7.628e-03 0.378 -2.326 CCPG1 cell cycle progression 1 15 -53434729, -53434729 AU144243 15q21.1 Hs.285051 5

cell cycle

membrane

integral to membrane

 
238877_at EYA4 eyes absent homolog 4 (Drosophila) 6 133604187 BE674583 6q23 Hs.596680 15

magnesium ion binding

protein tyrosine phosphatase activity

nucleus

cytoplasm

DNA repair

response to DNA damage stimulus

multicellular organismal development

visual perception

metabolic process

anatomical structure morphogenesis

chromatin modification

hydrolase activity

regulation of transcription

 
209721_s_at 0.415 7.258 2.670 1.732e-02 0.471 -3.021 IFFO1 intermediate filament family orphan 1 12 -6518954, -6518954 BC002857 12p13.3 Hs.15243 7

intermediate filament

 
211862_x_at 0.697 7.214 4.188 7.690e-04 0.211 -0.379 CFLAR CASP8 and FADD-like apoptosis regulator 2 201689060, 201689134, 201691631 AF015451 2q33-q34 Hs.390736 163

cysteine-type endopeptidase activity

protein binding

proteolysis

anti-apoptosis

induction of apoptosis by extracellular signals

regulation of apoptosis

positive regulation of I-kappaB kinase/NF-kappaB cascade

interspecies interaction between organisms

Apoptosis

236193_at 0.834 5.263 3.024 8.430e-03 0.388 -2.411 HIST1H2BC histone cluster 1, H2bc 6 -26231673 AA037483 6p21.3 Hs.658713 10

nucleosome

DNA binding

protein binding

nucleus

chromosome

nucleosome assembly

defense response to bacterium

Systemic lupus erythematosus

203066_at 1.346 6.357 3.724 1.994e-03 0.273 -1.184 CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 10 -125757173 NM_014863 10q26 Hs.287537 12

Golgi apparatus

membrane

integral to membrane

transferase activity

hexose biosynthetic process

3'-phosphoadenosine 5'-phosphosulfate binding

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

Chondroitin sulfate biosynthesis

1560097_at -0.384 4.776 -3.416 3.762e-03 0.317 -1.725 FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 1 15446354 AB067524 1p36.21 Hs.659997 6    
205149_s_at 0.666 5.396 3.541 2.908e-03 0.298 -1.506 CLCN4 chloride channel 4 X 10084984 NM_001830 Xp22.3 Hs.495674 17

nucleotide binding

ion channel activity

voltage-gated chloride channel activity

ATP binding

endosome

ion transport

chloride transport

antiporter activity

membrane

integral to membrane

chloride ion binding

 
234876_at COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 12 119360286 U82486 12q24.2 Hs.497118 11

cytochrome-c oxidase activity

mitochondrion

mitochondrial inner membrane

mitochondrial respiratory chain complex IV

generation of precursor metabolites and energy

membrane

Oxidative phosphorylation

Metabolic pathways

Cardiac muscle contraction

Alzheimer's disease

Parkinson's disease

Huntington's disease

209211_at 1.304 4.661 3.158 6.408e-03 0.364 -2.178 KLF5 Kruppel-like factor 5 (intestinal) 13 72531142 AF132818 13q22.1 Hs.508234 50

angiogenesis

transcription factor activity

RNA polymerase II transcription factor activity

protein binding

intracellular

nucleus

regulation of transcription, DNA-dependent

transcription from RNA polymerase II promoter

zinc ion binding

positive regulation of cell proliferation

microvillus assembly

positive regulation of transcription

metal ion binding

 
203883_s_at 0.333 7.209 3.478 3.310e-03 0.308 -1.615 RAB11FIP2 RAB11 family interacting protein 2 (class I) 10 -119754418 BG249608 10q26.11 Hs.173656 20

protein binding

endosome

plasma membrane

protein transport

Endocytosis

202263_at 0.440 11.457 3.012 8.645e-03 0.392 -2.432 CYB5R1 cytochrome b5 reductase 1 1 -201197624 NM_016243 1p36.13-q41 Hs.334832 8

cytochrome-b5 reductase activity

electron carrier activity

membrane

integral to membrane

sterol biosynthetic process

oxidoreductase activity

oxidation reduction

Amino sugar and nucleotide sugar metabolism

209025_s_at 0.429 7.549 2.472 2.572e-02 0.517 -3.353 SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 6 -86380411, -86380411, -86374221, -86374221, -86374221, -86374221 AF037448 6q14-q15 Hs.571177 33

nucleotide binding

RNA binding

protein binding

nucleus

nucleoplasm

spliceosomal complex

cytoplasm

endoplasmic reticulum

microsome

mRNA processing

poly(A) RNA binding

RNA splicing

interspecies interaction between organisms

 
237833_s_at -0.252 5.311 -2.396 2.987e-02 0.537 -3.478 SNCAIP synuclein, alpha interacting protein 5 121675718 BF062366 5q23.1-q23.3 Hs.426463 40

protein binding

cytoplasm

dopamine metabolic process

presynaptic membrane

cell soma

regulation of neurotransmitter secretion

Parkinson's disease

232252_at 0.510 9.385 3.593 2.611e-03 0.287 -1.414 DUSP27 dual specificity phosphatase 27 (putative) 1 165330710 AI822125 1q22-q24 Hs.632462 2

protein amino acid dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

phosphatase activity

 
201647_s_at SCARB2 scavenger receptor class B, member 2 4 -77298917 NM_005506 4q21.1 Hs.349656 Hs.714206 24

receptor activity

protein binding

membrane fraction

lysosome

integral to plasma membrane

cell adhesion

membrane

Lysosome

211476_at 0.948 8.067 2.167 4.654e-02 0.582 -3.845 MYOZ2 myozenin 2 4 120276386 AY013295 4q26-q27 Hs.381047 16

protein binding

cytoplasm

biological_process

actin cytoskeleton

sarcomere

Z disc

protein phosphatase 2B binding

 
213174_at 0.343 6.200 2.445 2.710e-02 0.525 -3.397 TTC9 tetratricopeptide repeat domain 9 14 70178256 BE675549 14q24.2 Hs.79170 5

binding

protein folding

 
206538_at 0.423 6.518 2.611 1.950e-02 0.490 -3.121 MRAS muscle RAS oncogene homolog 3 139549314, 139550197 NM_012219 3q22.3 Hs.527021 18

nucleotide binding

GTPase activity

GTP binding

intracellular

plasma membrane

Ras protein signal transduction

multicellular organismal development

muscle organ development

actin cytoskeleton organization

GTP-dependent protein binding

MAPK signaling pathway

Tight junction

Regulation of actin cytoskeleton

226561_at AGFG1 ArfGAP with FG repeats 1 2 228045131 BE551849 2q36.3 Hs.352962 29

DNA binding

RNA binding

protein binding

nucleus

nuclear pore

Golgi apparatus

mRNA export from nucleus

transport

multicellular organismal development

spermatogenesis

ARF GTPase activator activity

zinc ion binding

cell differentiation

cytoplasmic vesicle

regulation of ARF GTPase activity

metal ion binding

 
233516_s_at SPAG17 sperm associated antigen 17 1 -118297810 AL137581 1p12 Hs.528821 7

protein binding

cytoplasm

microtubule

cilium

flagellum

flagellar axoneme

 
217596_at 0.267 5.341 2.760 1.444e-02 0.447 -2.867 UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 13 114065179 AA649851 13q34 Hs.533855 20

nucleotide binding

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

RNA binding

nucleocytoplasmic transporter activity

protein binding

nucleus

cytoplasm

transport

mRNA transport

 
233557_s_at 0.247 5.174 2.638 1.845e-02 0.484 -3.074 MON1B MON1 homolog B (yeast) 16 75782336 AK023374 16q23.1 Hs.513743 6    
204281_at TEAD4 TEA domain family member 4 12 2938756, 2939222 NM_003213 12p13.3-p13.2 Hs.94865 16

skeletal system development

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

regulation of transcription from RNA polymerase II promoter

muscle organ development

 
238124_at 0.727 8.554 3.076 7.586e-03 0.378 -2.321 MYOM3 myomesin family, member 3 1 -24255117 AI124053 1p36.11 Hs.523413 4    
222976_s_at 0.755 8.823 3.415 3.774e-03 0.318 -1.727 TPM3 tropomyosin 3 1 -152400913, -152394403 BC000771 1q21.2 Hs.535581 Hs.644306 Hs.654421 66

molecular_function

actin binding

protein binding

cytoplasm

cytoskeleton

cytoskeleton

muscle thin filament tropomyosin

cell motion

regulation of muscle contraction

Cardiac muscle contraction

Pathways in cancer

Thyroid cancer

Hypertrophic cardiomyopathy (HCM)

229144_at 0.243 5.074 2.859 1.182e-02 0.426 -2.698 RP1-21O18.1 kazrin 1 14797799, 14797799, 15123211, 15128882, 15145001 AA989362 1p36.21 Hs.368823 10

nucleus

cytoplasm

cytoskeleton

cell junction

desmosome

keratinization

 
224726_at 0.268 7.604 2.338 3.343e-02 0.552 -3.572 MIB1 mindbomb homolog 1 (Drosophila) 18 17575542 W80418 18q11.2 Hs.140903 Hs.658808 15

blood vessel development

in utero embryonic development

somitogenesis

neural tube formation

heart looping

ubiquitin-protein ligase activity

protein binding

cytoplasm

plasma membrane

Notch signaling pathway

heart development

zinc ion binding

protein ubiquitination

ligase activity

modification-dependent protein catabolic process

cytoplasmic vesicle

negative regulation of neuron differentiation

positive regulation of endocytosis

metal ion binding

 
221755_at 0.310 7.999 2.340 3.331e-02 0.552 -3.569 EHBP1L1 EH domain binding protein 1-like 1 11 65100084 BG334196 11q13.1 Hs.502867 4    
209674_at 0.565 6.958 2.725 1.549e-02 0.458 -2.927 CRY1 cryptochrome 1 (photolyase-like) 12 -105909271 D83702 12q23-q24.1 Hs.151573 23

nucleotide binding

DNA binding

DNA photolyase activity

nucleus

cytoplasm

mitochondrion

DNA repair

circadian rhythm

G-protein coupled photoreceptor activity

protein-chromophore linkage

regulation of transcription

response to stimulus

Circadian rhythm - mammal

219757_s_at 0.354 4.706 2.339 3.338e-02 0.552 -3.570 C14orf101 chromosome 14 open reading frame 101 14 56116263 NM_017799 14q22.3 Hs.497253 3

membrane

integral to membrane

 
203156_at AKAP11 A kinase (PRKA) anchor protein 11 13 41744288 NM_016248 13q14.11 Hs.105105 14

cytoplasm

centrosome

protein kinase cascade

protein phosphatase 1 binding

protein kinase A binding

 
225859_at XIAP X-linked inhibitor of apoptosis X 122821728 N30645 Xq25 Hs.356076 170

protein binding

intracellular

cytoplasm

cytosol

cytosol

apoptosis

anti-apoptosis

zinc ion binding

ligase activity

modification-dependent protein catabolic process

peptidase inhibitor activity

caspase inhibitor activity

metal ion binding

Ubiquitin mediated proteolysis

Apoptosis

Focal adhesion

Pathways in cancer

Small cell lung cancer

200816_s_at PAFAH1B1 platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa) 17 2443672 NM_000430 17p13.3 Hs.77318 75

establishment of mitotic spindle orientation

astral microtubule

kinetochore

acrosome assembly

neuron migration

nucleus

cytoplasm

centrosome

spindle

cytosol

microtubule

microtubule associated complex

cell cortex

transport

cell cycle

mitosis

synaptic transmission

multicellular organismal development

nervous system development

neuroblast proliferation

learning or memory

microtubule binding

retrograde axon cargo transport

heparin binding

adult locomotory behavior

membrane

lipid catabolic process

corpus callosum morphogenesis

hippocampus development

layer formation in the cerebral cortex

cerebral cortex development

actin cytoskeleton organization

cell differentiation

microtubule organizing center organization

cell leading edge

motile primary cilium

nonmotile primary cilium

nuclear membrane

regulation of Rho GTPase activity

dynactin binding

protein homodimerization activity

phospholipase binding

dynein binding

platelet activating factor metabolic process

vesicle transport along microtubule

perinuclear region of cytoplasm

brain morphogenesis

neuromuscular process controlling balance

phosphoprotein binding

cell division

Ether lipid metabolism

Metabolic pathways

228067_at -0.484 5.292 -2.713 1.587e-02 0.459 -2.947 C2orf55 chromosome 2 open reading frame 55 2 -98776740 AW249666 2q11.2 Hs.469398 1    
200720_s_at 0.343 7.918 2.472 2.570e-02 0.517 -3.352 ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 10 -104228976 AL532341 10q24.32 Hs.153961 26

nucleotide binding

protein binding

ATP binding

cytoplasm

centrosome

cytoskeleton

dynactin complex

vesicle-mediated transport

 
213572_s_at 0.668 6.314 3.914 1.349e-03 0.245 -0.854 SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 6 -2778732 AI554300 6p25 Hs.381167 18

serine-type endopeptidase inhibitor activity

cytoplasm

peptidase inhibitor activity

 
210716_s_at 0.536 7.410 2.238 4.056e-02 0.570 -3.732 CLIP1 CAP-GLY domain containing linker protein 1 12 -121321933 M97501 12q24.3 Hs.524809 37

kinetochore

nucleic acid binding

protein binding

cytoplasm

endosome

microtubule

intermediate filament

mitosis

microtubule binding

zinc ion binding

protein homodimerization activity

metal ion binding

 
200655_s_at 0.494 10.516 4.067 9.861e-04 0.223 -0.588 CALM1 calmodulin 1 (phosphorylase kinase, delta) 14 89933125 NM_006888 14q24-q31 Hs.282410 Hs.708270 181  

Calcium signaling pathway

Phosphatidylinositol signaling system

Vascular smooth muscle contraction

Long-term potentiation

Neurotrophin signaling pathway

Olfactory transduction

Insulin signaling pathway

GnRH signaling pathway

Melanogenesis

Alzheimer's disease

Glioma

55692_at ELMO2 engulfment and cell motility 2 20 -44428096 W22924 20q13 Hs.210469 16

binding

cytoplasm

cytoskeleton

phagocytosis

apoptosis

SH3 domain binding

 
236305_at -0.495 5.307 -3.598 2.584e-03 0.287 -1.405 RFESD Rieske (Fe-S) domain containing 5 95008236, 95008338 AI769245 5q15 Hs.399758 2

iron ion binding

electron carrier activity

oxidoreductase activity

metal ion binding

2 iron, 2 sulfur cluster binding

oxidation reduction

 
218858_at DEPDC6 DEP domain containing 6 8 120955080 NM_022783 8q24.12 Hs.112981 11

protein binding

intracellular

negative regulation of protein kinase activity

intracellular signaling cascade

negative regulation of TOR signaling pathway

regulation of apoptosis

negative regulation of cell size

 
217795_s_at 0.240 7.794 2.253 3.942e-02 0.567 -3.708 TMEM43 transmembrane protein 43 3 14141440 W74580 3p25.1 Hs.517817 18

nucleus

endoplasmic reticulum

Golgi apparatus

membrane

integral to membrane

 
232983_s_at 0.380 6.112 3.211 5.741e-03 0.357 -2.084 SERGEF secretion regulating guanine nucleotide exchange factor 11 -17766171 AJ243951 11p14.3 Hs.32470 7

guanyl-nucleotide exchange factor activity

Ran guanyl-nucleotide exchange factor activity

protein binding

nucleus

cytoplasm

signal transduction

negative regulation of protein secretion

 
208816_x_at 0.630 8.124 4.294 6.205e-04 0.211 -0.199 ANXA2P2 annexin A2 pseudogene 2 9 33614222 M62898 9p13 Hs.534301 2

angiogenesis

phospholipase inhibitor activity

calcium ion binding

calcium-dependent phospholipid binding

phosphatidylinositol-4,5-bisphosphate binding

extracellular region

basement membrane

cytoplasm

early endosome

cytoskeletal protein binding

collagen fibril organization

sarcolemma

melanosome

fibrinolysis

protein complex

perinuclear region of cytoplasm

 
242663_at 0.333 4.550 3.006 8.759e-03 0.394 -2.444 LOC148189 hypothetical LOC148189 19 -32973241 AA115127 19q11 Hs.565253 2    
226137_at ZFHX3 zinc finger homeobox 3 16 -71374286 AI288759 16q22.3-q23.1 Hs.598297 26

negative regulation of transcription from RNA polymerase II promoter

RNA polymerase II transcription factor activity, enhancer binding

intracellular

nucleus

transcription factor complex

mitochondrion

regulation of transcription, DNA-dependent

zinc ion binding

transcription repressor activity

sequence-specific DNA binding

metal ion binding

 
218706_s_at 0.937 5.188 3.946 1.262e-03 0.238 -0.797 GRAMD3 GRAM domain containing 3 5 125723686, 125786767, 125828685 AW575493 5q23.2 Hs.363558 6    
225395_s_at 0.420 7.338 3.371 4.133e-03 0.323 -1.805 FAM120AOS family with sequence similarity 120A opposite strand 9 -95248602 AI309997 9q22.31 Hs.350364 Hs.709859 3    
227226_at -0.426 4.460 -3.579 2.691e-03 0.290 -1.439 MRAP2 melanocortin 2 receptor accessory protein 2 6 84800138 AA418816 6q14.2 Hs.370055 8    
217755_at 0.815 7.671 2.540 2.245e-02 0.500 -3.239 HN1 hematological and neurological expressed 1 17 -70642938, -70642938 NM_016185 17q25.1 Hs.532803 Hs.713826 9

nucleus

 
217165_x_at 0.971 8.412 4.805 2.227e-04 0.172 0.655 MT1F metallothionein 1F 16 55249355 M10943 16q13 Hs.513626 20

copper ion binding

cytoplasm

biological_process

zinc ion binding

cadmium ion binding

metal ion binding

 
214757_at 0.242 3.961 2.298 3.613e-02 0.558 -3.636 PMS2L2 postmeiotic segregation increased 2-like 2 pseudogene 7 -74815899, 72114615 BG178274 7q11-q22 Hs.292996 Hs.661055 Hs.675888 4

molecular_function

ATP binding

cellular_component

mismatch repair

biological_process

mismatched DNA binding

 
226615_at XPR1 xenotropic and polytropic retrovirus receptor 1 178867768 BE439489 1q25.1 Hs.227656 6

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

G-protein coupled receptor protein signaling pathway

 
208598_s_at 0.267 7.922 2.400 2.961e-02 0.536 -3.471 HUWE1 HECT, UBA and WWE domain containing 1 X -53575796 NM_005703 Xp11.22 Hs.136905 28

protein polyubiquitination

DNA binding

ubiquitin-protein ligase activity

protein binding

intracellular

nucleus

nucleolus

cytoplasm

protein modification process

histone ubiquitination

ligase activity

acid-amino acid ligase activity

modification-dependent protein catabolic process

cell differentiation

Ubiquitin mediated proteolysis

208370_s_at 0.623 7.490 2.762 1.438e-02 0.447 -2.864 RCAN1 regulator of calcineurin 1 21 -34810653, -34810653, -34810653 NM_004414 21q22.1-q22.2 21q22.12 Hs.282326 45

transcription factor activity

protein binding

nucleus

cytoplasm

signal transduction

central nervous system development

blood circulation

response to mechanical stimulus

calcium-mediated signaling

response to estrogen stimulus

regulation of phosphoprotein phosphatase activity

skeletal muscle fiber development

negative regulation of smooth muscle cell differentiation

 
202158_s_at CUGBP2 CUG triplet repeat, RNA binding protein 2 10 11087264, 11099898, 11246998 NM_006561 10p13 Hs.309288 25

nucleotide binding

RNA binding

protein binding

nucleus

cytoplasm

mRNA processing

regulation of heart contraction

 
213479_at 1.185 4.185 5.274 8.927e-05 0.162 1.403 NPTX2 neuronal pentraxin II 7 98084532 U26662 7q21.3-q22.1 Hs.3281 13

molecular_function

calcium ion binding

sugar binding

extracellular region

synaptic transmission

 
225024_at RPRD1B regulation of nuclear pre-mRNA domain containing 1B 20 36095361 AL117521 20q11.21-q12 Hs.278839 7    
231773_at 0.757 7.221 2.839 1.231e-02 0.427 -2.733 ANGPTL1 angiopoietin-like 1 1 -177085292 BF002046 1q25.2 Hs.591474 19

receptor binding

extracellular region

extracellular space

signal transduction

 
236313_at 1.876 5.377 3.675 2.203e-03 0.276 -1.269 CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 9 -21992901 AW444761 9p21 Hs.72901 158

regulation of cyclin-dependent protein kinase activity

G2/M transition of mitotic cell cycle

cyclin-dependent protein kinase inhibitor activity

protein binding

cytoplasm

cell cycle

cell cycle arrest

protein kinase binding

positive regulation of transforming growth factor beta receptor signaling pathway

G1/S transition checkpoint

cellular response to extracellular stimulus

cellular response to nutrient

negative regulation of phosphorylation

negative regulation of epithelial cell proliferation

Cell cycle

TGF-beta signaling pathway

Pathways in cancer

Small cell lung cancer

239996_x_at ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 12 109203414, 109203414 AI671237 12q23-q24.1 Hs.506759 84

nucleotide binding

magnesium ion binding

regulation of the force of heart contraction

calcium-transporting ATPase activity

calcium ion binding

ATP binding

membrane fraction

microsome

integral to plasma membrane

ATP biosynthetic process

cation transport

cellular calcium ion homeostasis

ER-nuclear signaling pathway

cell adhesion

metabolic process

epidermis development

membrane

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

sarcoplasmic reticulum membrane

negative regulation of heart contraction

S100 alpha binding

sarcoplasmic reticulum calcium ion transport

Calcium signaling pathway

Cardiac muscle contraction

Alzheimer's disease

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

238049_at 0.553 3.958 4.067 9.850e-04 0.223 -0.588 GRAMD3 GRAM domain containing 3 5 125723686, 125786767, 125828685 AW971198 5q23.2 Hs.363558 6    
204285_s_at 0.964 4.893 4.287 6.289e-04 0.211 -0.210 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 18 55718171 AI857639 18q21.32 Hs.96 36

release of cytochrome c from mitochondria

protein binding

mitochondrion

induction of apoptosis

activation of caspase activity

cell structure disassembly during apoptosis

virus-infected cell apoptosis

response to dsRNA

p53 signaling pathway

231779_at 0.565 6.289 2.966 9.492e-03 0.402 -2.512 IRAK2 interleukin-1 receptor-associated kinase 2 3 10181562 AI246590 3p25.3 Hs.449207 15

regulation of cytokine-mediated signaling pathway

MyD88-dependent toll-like receptor signaling pathway

protein kinase activity

NF-kappaB-inducing kinase activity

ATP binding

protein amino acid phosphorylation

inflammatory response

signal transduction

I-kappaB kinase/NF-kappaB cascade

cell surface

lipopolysaccharide-mediated signaling pathway

negative regulation of NF-kappaB transcription factor activity

protein homodimerization activity

protein heterodimerization activity

positive regulation of NF-kappaB transcription factor activity

interleukin-1-mediated signaling pathway

response to interleukin-1

Apoptosis

Neurotrophin signaling pathway

209014_at 0.506 8.529 2.829 1.256e-02 0.429 -2.749 MAGED1 melanoma antigen family D, 1 X 51562894, 51653437 AF217963 Xp11.23 Hs.5258 29

transcription coactivator activity

cytoplasm

plasma membrane

regulation of transcription from RNA polymerase II promoter

identical protein binding

regulation of apoptosis

protein complex

negative regulation of epithelial cell proliferation

Neurotrophin signaling pathway

200808_s_at -0.282 5.609 -3.394 3.940e-03 0.321 -1.764 ZYX zyxin 7 142788481 NM_003461 7q32 Hs.490415 38

stress fiber

protein binding

nucleus

cytoplasm

cytoskeleton

plasma membrane

integral to plasma membrane

cell-cell adherens junction

focal adhesion

cell adhesion

signal transduction

cell-cell signaling

zinc ion binding

interspecies interaction between organisms

metal ion binding

Focal adhesion

233669_s_at 0.378 7.947 3.246 5.348e-03 0.351 -2.024 TRIM54 tripartite motif-containing 54 2 27359103 AA868267 2p23.3 Hs.516036 5

signal transducer activity

protein binding

intracellular

cytoplasm

cytoskeleton

microtubule

microtubule associated complex

microtubule-based process

negative regulation of microtubule depolymerization

signal transduction

multicellular organismal development

microtubule binding

zinc ion binding

Z disc

cell differentiation

metal ion binding

 
235042_at 1.131 9.868 3.223 5.605e-03 0.354 -2.064 XIRP1 xin actin-binding repeat containing 1 3 -39199710 AW755250 3p22.2 Hs.447868 7

actin binding

fascia adherens

negative regulation of cell proliferation

actin cytoskeleton organization

cell junction

regulation of membrane potential

sarcomere organization

cardiac muscle cell development

 
212606_at 0.334 6.864 2.467 2.596e-02 0.518 -3.361 WDFY3 WD repeat and FYVE domain containing 3 4 -85949008, -85809722, -85809722 AL536319 4q21.23 Hs.480116 10

binding

zinc ion binding

membrane

metal ion binding

 
227395_at 0.803 5.119 3.342 4.382e-03 0.328 -1.854 TBCEL tubulin folding cofactor E-like 11 120400012, 120400022 BE672045 11q23.3 Hs.504136 4

cytoplasm

cytoskeleton

 
213885_at -0.275 5.643 -3.186 6.045e-03 0.360 -2.128 TRIM3 tripartite motif-containing 3 11 -6426418 AA114843 11p15.5 Hs.591992 11

intracellular

cytoplasm

early endosome

nervous system development

protein C-terminus binding

zinc ion binding

protein transport

metal ion binding

 
238228_at 0.792 4.849 3.845 1.553e-03 0.254 -0.973 COG3 component of oligomeric golgi complex 3 13 44937071 AI732206 13q14.13 Hs.507948 15

Golgi apparatus

cis-Golgi network

protein amino acid glycosylation

intracellular protein transport

ER to Golgi vesicle-mediated transport

retrograde vesicle-mediated transport, Golgi to ER

intra-Golgi vesicle-mediated transport

protein transporter activity

membrane

Golgi transport complex

protein localization in organelle

protein stabilization

 
223960_s_at 0.288 6.790 2.385 3.053e-02 0.541 -3.496 C16orf5 chromosome 16 open reading frame 5 16 -4500677 AF195661 16p13.3 Hs.654653 6

molecular_function

nucleus

apoptosis

induction of apoptosis

biological_process

tumor necrosis factor-mediated signaling pathway

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

 
205338_s_at -0.353 4.924 -3.273 5.060e-03 0.345 -1.977 DCT dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) 13 -93889841 NM_001922 13q32 Hs.301865 41

dopachrome isomerase activity

copper ion binding

microsome

cytosol

melanin biosynthetic process from tyrosine

metabolic process

zinc ion binding

epidermis development

membrane

integral to membrane

oxidoreductase activity

isomerase activity

melanosome

metal ion binding

pigmentation during development

cell development

Tyrosine metabolism

Metabolic pathways

Melanogenesis

210813_s_at 0.478 3.200 3.002 8.833e-03 0.394 -2.451 XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 5 82409072 BC005259 5q13-q14 Hs.567359 93

condensed chromosome

in utero embryonic development

pro-B cell differentiation

DNA binding

nucleus

nucleus

cytosol

DNA-dependent protein kinase-DNA ligase 4 complex

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

response to DNA damage stimulus

central nervous system development

protein C-terminus binding

response to X-ray

response to gamma radiation

ligase activity

provirus integration

initiation of viral infection

DNA ligase IV complex

T cell differentiation in the thymus

immunoglobulin V(D)J recombination

negative regulation of neuron apoptosis

isotype switching

positive regulation of fibroblast proliferation

positive regulation of neurogenesis

DNA ligation during DNA repair

positive regulation of ligase activity

Non-homologous end-joining

230484_at -0.196 5.199 -2.699 1.633e-02 0.463 -2.971 CHDH choline dehydrogenase 3 -53825427 AI741739 3p21.1 Hs.126688 5

mitochondrion

mitochondrial inner membrane

alcohol metabolic process

choline dehydrogenase activity

FAD binding

oxidation reduction

Glycine, serine and threonine metabolism

203560_at 0.929 4.186 2.944 9.941e-03 0.412 -2.551 GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 8 -64090196 NM_003878 8q12.3 Hs.78619 29

extracellular region

extracellular space

lysosome

glutamine metabolic process

hydrolase activity

gamma-glutamyl-peptidase activity

melanosome

Folate biosynthesis

220617_s_at ZNF532 zinc finger protein 532 18 54681040 NM_018181 18q21.32 Hs.529023 Hs.607676 4

DNA binding

intracellular

nucleus

nucleolus

Golgi apparatus

zinc ion binding

regulation of transcription

metal ion binding

 
210887_s_at EVC Ellis van Creveld syndrome 4 5763824 AF216185 4p16 Hs.646899 Hs.670028 13

skeletal system development

muscle organ development

membrane

integral to membrane

 
212934_at UBXN2B UBX domain protein 2B 8 59486376 AI245523 8q12.1 Hs.155572 4

nucleus

cytoplasm

endoplasmic reticulum

Golgi apparatus

cytosol

 
226334_s_at 0.353 6.675 2.707 1.606e-02 0.459 -2.957 AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) 2 61258324 AW117717 2p15 Hs.655602 6

ATPase activator activity

cytoplasm

response to stress

chaperone binding

 
226003_at KIF21A kinesin family member 21A 12 -37973296 AB051495 12q12 Hs.374201 25

nucleotide binding

microtubule motor activity

ATP binding

microtubule

microtubule-based movement

 
215351_at RTCD1 RNA terminal phosphate cyclase domain 1 1 100504301 BG536504 1p21.2 Hs.484222 7

nucleotide binding

RNA binding

RNA-3'-phosphate cyclase activity

ATP binding

nucleus

nucleoplasm

RNA processing

 
201676_x_at 0.292 10.708 3.602 2.565e-03 0.287 -1.399 PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 11 -14492087, -14482998, -14482998 NM_002786 11p15.1 Hs.102798 Hs.445711 52

RNA binding

threonine-type endopeptidase activity

protein binding

nucleus

cytoplasm

cytosol

proteasome core complex

polysome

ubiquitin-dependent protein catabolic process

peptidase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

proteolysis involved in cellular protein catabolic process

Proteasome

211316_x_at 0.595 8.529 3.578 2.695e-03 0.290 -1.441 CFLAR CASP8 and FADD-like apoptosis regulator 2 201689060, 201689134, 201691631 AF009616 2q33-q34 Hs.390736 163

cysteine-type endopeptidase activity

protein binding

proteolysis

anti-apoptosis

induction of apoptosis by extracellular signals

regulation of apoptosis

positive regulation of I-kappaB kinase/NF-kappaB cascade

interspecies interaction between organisms

Apoptosis

1557950_at 0.366 6.619 2.407 2.919e-02 0.535 -3.459 SDCCAG1 serologically defined colon cancer antigen 1 14 -49320281 BF984340 14q22 Hs.655964 8

nucleus

cytoplasm

 
204359_at 0.488 8.107 2.322 3.452e-02 0.553 -3.598 FLRT2 fibronectin leucine rich transmembrane protein 2 14 85066240 NM_013231 14q24-q32 Hs.533710 Hs.624735 Hs.719261 9

receptor signaling protein activity

proteinaceous extracellular matrix

integral to plasma membrane

cell adhesion

biological_process

membrane

protein binding, bridging

 
225894_at 0.411 11.477 2.551 2.200e-02 0.499 -3.222 SYNPO2 synaptopodin 2 4 120029443, 120029443 AL589603 4q26 Hs.655519 14

actin binding

protein binding

nucleus

cytoplasm

 
238039_at 0.465 4.326 3.694 2.121e-03 0.276 -1.237 LOC728769 hypothetical protein LOC728769 5   BG180437 5q14.1 Hs.586193      
201939_at 0.687 5.403 3.040 8.156e-03 0.387 -2.383 PLK2 polo-like kinase 2 (Drosophila) 5 -57785566 NM_006622 5q12.1-q13.2 Hs.398157 Hs.658132 20

nucleotide binding

mitotic cell cycle

protein serine/threonine kinase activity

signal transducer activity

protein binding

ATP binding

protein amino acid phosphorylation

transferase activity

polo kinase kinase activity

positive regulation of I-kappaB kinase/NF-kappaB cascade

 
204781_s_at FAS Fas (TNF receptor superfamily, member 6) 10 90740267, 90740267 NM_000043 10q24.1 Hs.244139 589

immunoglobulin production

renal system process

transmembrane receptor activity

extracellular region

soluble fraction

cytosol

plasma membrane

plasma membrane

protein complex assembly

anti-apoptosis

activation-induced cell death of T cells

inflammatory cell apoptosis

transformed cell apoptosis

immune response

signal transduction

induction of apoptosis via death domain receptors

activation of pro-apoptotic gene products

response to toxin

external side of plasma membrane

gene expression

positive regulation of necrotic cell death

integral to membrane

B cell mediated immunity

kinase binding

death-inducing signaling complex

identical protein binding

negative thymic T cell selection

regulation of lymphocyte differentiation

regulation of myeloid cell differentiation

spleen development

negative regulation of B cell activation

protein homooligomerization

response to glucocorticoid stimulus

response to protein stimulus

MAPK signaling pathway

Cytokine-cytokine receptor interaction

p53 signaling pathway

Apoptosis

Natural killer cell mediated cytotoxicity

Type I diabetes mellitus

Alzheimer's disease

Pathways in cancer

Autoimmune thyroid disease

Allograft rejection

Graft-versus-host disease

226353_at SPPL2A signal peptide peptidase-like 2A 15 -48787028 AI674647 15q21.2 Hs.401537 12

aspartic-type endopeptidase activity

peptidase activity

membrane

integral to membrane

 
221052_at -0.349 3.135 -4.045 1.031e-03 0.225 -0.626 TDRKH tudor and KH domain containing 1 -150012579, -150010664 NM_006862 1q21 Hs.144439 8

RNA binding

 
221821_s_at C12orf41 chromosome 12 open reading frame 41 12 -47333261 AK022732 12q13.11 Hs.505412 8    
226787_at 0.252 5.360 2.258 3.905e-02 0.567 -3.700 ZNF18 zinc finger protein 18 17 -11821486 BF966015 17p11.2 Hs.370473 8

transcription factor activity

intracellular

nucleus

nucleolus

cytoplasm

Golgi apparatus

plasma membrane

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
208015_at 0.487 5.324 3.349 4.324e-03 0.328 -1.843 SMAD1 SMAD family member 1 4 146622400, 146623406 NM_015583 4q31 Hs.604588 118

MAPKKK cascade

mesodermal cell fate commitment

osteoblast fate commitment

transcription factor activity

RNA polymerase II transcription factor activity

receptor signaling protein activity

intracellular

nucleus

nucleoplasm

transcription factor complex

cytoplasm

cytosol

inflammatory response

signal transduction

transforming growth factor beta receptor signaling pathway

SMAD protein complex assembly

gamete generation

negative regulation of cell proliferation

embryonic pattern specification

positive regulation of gene expression

integral to membrane

transcription activator activity

BMP signaling pathway

BMP signaling pathway

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

midbrain development

hindbrain development

primary microRNA processing

homeostatic process

identical protein binding

positive regulation of osteoblast differentiation

positive regulation of transcription from RNA polymerase II promoter

co-SMAD binding

TGF-beta signaling pathway

1555778_a_at 1.455 3.054 3.760 1.852e-03 0.271 -1.122 POSTN periostin, osteoblast specific factor 13 -37034719 AY140646 13q13.3 Hs.136348 38

skeletal system development

protein binding

extracellular region

proteinaceous extracellular matrix

cell adhesion

heparin binding

 
36829_at PER1 period homolog 1 (Drosophila) 17 -7984512 AF022991 17p13.1-p12 Hs.445534 54

signal transducer activity

nucleus

cytoplasm

regulation of transcription, DNA-dependent

signal transduction

circadian rhythm

entrainment of circadian clock

negative regulation of transcription

Circadian rhythm - mammal

36553_at 0.538 6.751 2.507 2.399e-02 0.509 -3.295 ASMTL acetylserotonin O-methyltransferase-like X, Y -1482031, -1482031 AA669799 Xp22.3 Yp11.3 Hs.533514 10

cellular_component

cytoplasm

acetylserotonin O-methyltransferase activity

melatonin biosynthetic process

 
239390_at GTDC1 glycosyltransferase-like domain containing 1 2 -144420052, -144420050 BE327650 2q22.3 Hs.44780 3

biosynthetic process

transferase activity, transferring glycosyl groups

 
232510_s_at 0.366 6.473 2.922 1.039e-02 0.418 -2.588 DPP3 dipeptidyl-peptidase 3 11 66004455 AW250952 11q12-q13.1 Hs.502914 29

aminopeptidase activity

cytoplasm

proteolysis

peptidase activity

metallopeptidase activity

dipeptidyl-peptidase activity

zinc ion binding

metal ion binding

 
221483_s_at 0.320 9.330 2.811 1.303e-02 0.433 -2.780 ARPP19 cAMP-regulated phosphoprotein, 19kDa 15 -50626723 AF084555 15q21.2 Hs.512908 10

receptor binding

cytoplasm

potassium channel regulator activity

positive regulation of gluconeogenesis

positive regulation of glucose import

 
223044_at 0.521 9.868 3.614 2.499e-03 0.287 -1.376 SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 2 -190133560 AL136944 2q32 Hs.643005 73

iron ion transmembrane transporter activity

iron ion binding

cytoplasm

plasma membrane

integral to plasma membrane

ion transport

iron ion transport

cellular iron ion homeostasis

synaptic vesicle

anatomical structure morphogenesis

 
223908_at 0.437 4.374 2.201 4.357e-02 0.578 -3.791 HDAC8 histone deacetylase 8 X -71466090 AF212246 Xq13 Hs.310536 23

histone deacetylase complex

negative regulation of transcription from RNA polymerase II promoter

nuclear chromosome

histone deacetylase activity

nucleus

cytoplasm

chromatin assembly or disassembly

transcription factor binding

chromatin modification

histone deacetylation

hydrolase activity

regulation of transcription

 
229412_at 0.486 5.685 2.917 1.051e-02 0.418 -2.598 TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 6 42126228 AA641254 6p21.1 Hs.520122 17

inner cell mass cell proliferation

DNA binding

protein binding

nucleus

transcription factor TFIID complex

cytoplasm

multicellular organismal development

transcription activator activity

cell differentiation

regulation of transcription

regulation of fat cell differentiation

positive regulation of transcription, DNA-dependent

 
215716_s_at ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 12 -88505956 L14561 12q21.3 Hs.506276 38

nucleotide binding

magnesium ion binding

calcium-transporting ATPase activity

calcium ion binding

calmodulin binding

ATP binding

plasma membrane

integral to plasma membrane

ATP biosynthetic process

cation transport

calcium ion transport

metabolic process

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Calcium signaling pathway

221823_at 0.404 5.944 2.243 4.023e-02 0.569 -3.725 C5orf30 chromosome 5 open reading frame 30 5 102622340 AL565741 5q21.1 Hs.482976 4    
215667_x_at 0.324 5.992 2.546 2.221e-02 0.500 -3.230 PMS2L1 postmeiotic segregation increased 2-like 1 pseudogene 7 -99756198 AI375694 7q22.1 Hs.634244 Hs.661055 Hs.709266 7

molecular_function

ATP binding

cellular_component

mismatch repair

biological_process

kinase activity

transferase activity

mismatched DNA binding

 
230876_at LOC169834 hypothetical protein LOC169834 9 -114799220 AI827906 9q32 Hs.192877 1    
226942_at PHF20L1 PHD finger protein 20-like 1 8 133856785, 133856785, 133856785 AI742668 8q24.22 Hs.304362 4

nucleic acid binding

protein binding

zinc ion binding

metal ion binding

 
205151_s_at 0.631 6.215 4.013 1.101e-03 0.227 -0.681 KIAA0644 KIAA0644 gene product 7 -28959498 NM_014817 7p14.3 Hs.719240 4

protein binding

membrane

integral to membrane

 
214151_s_at 0.458 7.368 3.101 7.201e-03 0.374 -2.277 CCPG1 cell cycle progression 1 15 -53434729, -53434729 AU144243 15q21.1 Hs.285051 5

cell cycle

membrane

integral to membrane

 
207675_x_at -0.231 4.688 -2.284 3.711e-02 0.562 -3.658 ARTN artemin 1 44171578, 44173617, 44174240 NM_003976 1p33-p32 Hs.632404 14

extracellular region

signal transduction

neuroblast proliferation

growth factor activity

 
239183_at 0.837 6.216 3.149 6.531e-03 0.364 -2.194 ANGPTL1 angiopoietin-like 1 1 -177085292 W67461 1q25.2 Hs.591474 19

receptor binding

extracellular region

extracellular space

signal transduction

 
212566_at 0.310 10.545 2.448 2.694e-02 0.525 -3.392 MAP4 microtubule-associated protein 4 3 -47989573, -47867183, -47867183 AL523310 3p21 Hs.517949 40

structural molecule activity

protein binding

microtubule

microtubule associated complex

negative regulation of microtubule depolymerization

 
209281_s_at ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 12 -88505956 M95541 12q21.3 Hs.506276 38

nucleotide binding

magnesium ion binding

calcium-transporting ATPase activity

calcium ion binding

calmodulin binding

ATP binding

plasma membrane

integral to plasma membrane

ATP biosynthetic process

cation transport

calcium ion transport

metabolic process

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Calcium signaling pathway

218178_s_at 0.823 8.778 4.247 6.827e-04 0.211 -0.279 CHMP1B chromatin modifying protein 1B 18 11841388 NM_020412 18p11.21 Hs.656244 16

cytoplasm

endosome

cytosol

cell cycle

protein transport

membrane

protein domain specific binding

cell division

Endocytosis

213152_s_at SFRS2B splicing factor, arginine/serine-rich 2B 11 94439703 AI343248 11q22 Hs.476680 Hs.713908 6

nucleotide binding

RNA binding

nucleus

mRNA processing

RNA splicing

 
203485_at 0.629 5.012 3.798 1.712e-03 0.267 -1.056 RTN1 reticulon 1 14 -59132446, -59132446, -59132446 NM_021136 14q23.1 Hs.368626 23

signal transducer activity

endoplasmic reticulum

signal transduction

membrane

integral to membrane

integral to endoplasmic reticulum membrane

neuron differentiation

 
1552887_at C10orf27 chromosome 10 open reading frame 27 10 -72201000 NM_152710 10q22.1 Hs.386698 5

protein binding

cytoplasm

cytosol

multicellular organismal development

spermatogenesis

cell differentiation

 
235341_at -0.336 4.596 -3.726 1.986e-03 0.273 -1.181 DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 13 95127402 AL119957 13q32.1 Hs.59214 19

protein kinase inhibitor activity

binding

cytoplasm

endoplasmic reticulum

response to unfolded protein

response to virus

heat shock protein binding

 
213215_at 0.327 7.231 2.434 2.769e-02 0.527 -3.415 AP3S2 adaptor-related protein complex 3, sigma 2 subunit 15 -88174834 AI910895 15q26.1 Hs.632161 14

protein binding

Golgi apparatus

intracellular protein transport

protein transporter activity

membrane

vesicle-mediated transport

membrane coat

cytoplasmic vesicle

Lysosome

1555976_s_at 1.076 6.343 3.558 2.810e-03 0.294 -1.476 MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 18 3237527 BU676221 18p11.31 Hs.190086 9

motor activity

calcium ion binding

protein binding

myosin complex

Focal adhesion

Tight junction

Leukocyte transendothelial migration

Regulation of actin cytoskeleton

219366_at AVEN apoptosis, caspase activation inhibitor 15 -31945719 NM_020371 15q13.1 Hs.555966 10

protein binding

intracellular

membrane fraction

apoptosis

anti-apoptosis

membrane

 
204324_s_at GOLIM4 golgi integral membrane protein 4 3 -169210347 NM_014498 3q26.2 Hs.143600 10

nucleus

endosome

Golgi apparatus

Golgi lumen

cis-Golgi network

transport

membrane

integral to membrane

endocytic vesicle

 
238462_at 0.451 2.700 2.888 1.113e-02 0.425 -2.647 UBASH3B ubiquitin associated and SH3 domain containing, B 11 122031607 AI418293 11q24.1 Hs.444075 15

nucleus

cytoplasm

 
200671_s_at 0.571 5.770 3.848 1.543e-03 0.254 -0.967 SPTBN1 spectrin, beta, non-erythrocytic 1 2 54536957, 54639034 N92501 2p21 Hs.503178 Hs.705692 46

actin binding

structural constituent of cytoskeleton

calmodulin binding

nucleus

nucleolus

cytoplasm

plasma membrane

common-partner SMAD protein phosphorylation

SMAD protein nuclear translocation

spectrin

cortical cytoskeleton

M band

actin filament capping

 
225997_at MOBKL1A MOB1, Mps One Binder kinase activator-like 1A (yeast) 4 71986927 AL162039 4q13.3 Hs.700445 Hs.719746 6

protein binding

nucleus

cytoplasm

zinc ion binding

kinase activator activity

kinase binding

protein amino acid autophosphorylation

metal ion binding

 
243318_at DCAF8 DDB1 and CUL4 associated factor 8 1 -158475636, -158475636, -158452128, -158452128 AI208342 1q22-q23 Hs.632447 10

protein binding

 
217838_s_at 0.521 6.515 3.321 4.584e-03 0.333 -1.893 EVL Enah/Vasp-like 14 99601503 NM_016337 14q32.2 Hs.125867 24

actin binding

profilin binding

cytoplasm

cytoskeleton

focal adhesion

cell surface receptor linked signal transduction

nervous system development

actin polymerization or depolymerization

organ morphogenesis

SH3 domain binding

lamellipodium

 
1555427_s_at 0.524 5.246 2.911 1.062e-02 0.418 -2.607 SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 6 -86380411, -86380411, -86374221, -86374221, -86374221, -86374221 AY034482 6q14-q15 Hs.571177 33

nucleotide binding

RNA binding

protein binding

nucleus

nucleoplasm

spliceosomal complex

cytoplasm

endoplasmic reticulum

microsome

mRNA processing

poly(A) RNA binding

RNA splicing

interspecies interaction between organisms

 
243492_at 0.337 5.594 2.239 4.052e-02 0.570 -3.731 THEM4 thioesterase superfamily member 4 1 -150112683 AW972653 1q21 Hs.164070 8

cytoplasm

plasma membrane

ruffle membrane

cell projection

 
206633_at 2.819 7.373 3.885 1.431e-03 0.250 -0.903 CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2 -175320568 NM_000079 2q24-q32 Hs.434479 43

skeletal muscle contraction

nicotinic acetylcholine-activated cation-selective channel activity

ion channel activity

extracellular ligand-gated ion channel activity

plasma membrane

nicotinic acetylcholine-gated receptor-channel complex

ion transport

signal transduction

neuromuscular synaptic transmission

neuromuscular junction development

cell surface

acetylcholine receptor activity

integral to membrane

regulation of action potential in neuron

cell junction

neuromuscular junction

regulation of membrane potential

postsynaptic membrane

muscle maintenance

skeletal muscle tissue growth

neuromuscular process

neuron maintenance

 
204742_s_at PDS5B PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 13 32058591 NM_015032 13q12.3 Hs.716441 15

chromatin

DNA binding

ATP binding

nucleus

cell cycle

mitotic sister chromatid cohesion

mitosis

negative regulation of cell proliferation

identical protein binding

cell division

 
203836_s_at -0.497 6.368 -2.553 2.190e-02 0.499 -3.218 MAP3K5 mitogen-activated protein kinase kinase kinase 5 6 -136919879 D84476 6q22.33 Hs.186486 108

MAPKKK cascade

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

ATP binding

protein amino acid phosphorylation

apoptosis

activation of JUN kinase activity

induction of apoptosis by extracellular signals

caspase activator activity

transferase activity

protein homodimerization activity

interspecies interaction between organisms

MAPK signaling pathway

Neurotrophin signaling pathway

Amyotrophic lateral sclerosis (ALS)

221029_s_at WNT5B wingless-type MMTV integration site family, member 5B 12 1596482, 1608672 NM_030775 12p13.3 Hs.306051 11

signal transducer activity

extracellular region

proteinaceous extracellular matrix

Wnt receptor signaling pathway, calcium modulating pathway

multicellular organismal development

Wnt signaling pathway

Hedgehog signaling pathway

Melanogenesis

Pathways in cancer

Basal cell carcinoma

218934_s_at 0.591 10.768 2.998 8.894e-03 0.395 -2.457 HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 1 -16213109 NM_014424 1p36.23-p34.3 Hs.502612 7

response to unfolded protein

regulation of heart contraction

protein C-terminus binding

response to heat

 
226230_at 0.418 6.581 2.618 1.922e-02 0.489 -3.108 SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 2 -55629017 AA541716 2p16.1 Hs.516182 16

protein binding

nucleus

cytoplasm

centrosome

 
207717_s_at PKP2 plakophilin 2 12 -32834946 NM_004572 12p11 Hs.164384 29

protein binding

nucleus

cytoskeleton

plasma membrane

integral to membrane

cell-cell adhesion

desmosome

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

229459_at 0.718 2.636 5.134 1.171e-04 0.162 1.183 FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 22 47263951, 47350781 AV723914 22q13.32 Hs.436854 Hs.632788 8

extracellular region

membrane

integral to membrane

 
224879_at -0.538 10.010 -2.671 1.728e-02 0.471 -3.019 C9orf123 chromosome 9 open reading frame 123 9 -7786490 BF315994 9p24.1 Hs.7517 4

membrane

integral to membrane

 
212539_at CHD1L chromodomain helicase DNA binding protein 1-like 1 145180914 AI422099 1q12 Hs.191164 12

nucleotide binding

DNA binding

helicase activity

ATP binding

nucleus

ATP-dependent helicase activity

hydrolase activity

 
200962_at -0.880 5.997 -3.634 2.399e-03 0.284 -1.342 RPL31 ribosomal protein L31 2 100985122, 100985122 AI348010 2q11.2 Hs.469473 21

RNA binding

structural constituent of ribosome

protein binding

intracellular

cytosol

ribosome

translational elongation

cytosolic large ribosomal subunit

Ribosome

211808_s_at -0.217 5.027 -2.511 2.379e-02 0.509 -3.288 CREBBP CREB binding protein 16 -3715056 U85962 16p13.3 Hs.459759 399

histone acetyltransferase complex

response to hypoxia

p53 binding

transcription factor activity

transcription coactivator activity

transcription coactivator activity

histone acetyltransferase activity

signal transducer activity

nucleus

cytoplasm

regulation of transcription, DNA-dependent

protein complex assembly

signal transduction

zinc ion binding

acetyltransferase activity

histone acetylation

transferase activity

N-terminal peptidyl-lysine acetylation

homeostatic process

interspecies interaction between organisms

positive regulation of transcription

positive regulation of transcription

metal ion binding

MyoD binding

Cell cycle

Wnt signaling pathway

Notch signaling pathway

TGF-beta signaling pathway

Adherens junction

Jak-STAT signaling pathway

Long-term potentiation

Melanogenesis

Huntington's disease

Pathways in cancer

Renal cell carcinoma

Prostate cancer

204407_at 0.764 3.787 2.894 1.101e-02 0.424 -2.638 TTF2 transcription termination factor, RNA polymerase II 1 117404471 AF080255 1p22 Hs.486818 12

nucleotide binding

DNA binding

RNA polymerase II transcription termination factor activity

helicase activity

ATP binding

nucleus

spliceosomal complex

cytoplasm

transcription termination

mRNA processing

transcription elongation factor complex

ATP-dependent helicase activity

DNA-dependent ATPase activity

zinc ion binding

RNA splicing

hydrolase activity

regulation of transcription

 
1552701_a_at CARD16 caspase recruitment domain family, member 16 11 -104417262 NM_052889   Hs.348365 8

cysteine-type endopeptidase activity

cysteine-type endopeptidase inhibitor activity

protein binding

intracellular

proteolysis

peptidase inhibitor activity

regulation of apoptosis

 
226066_at 0.370 8.536 2.625 1.894e-02 0.488 -3.096 MITF microphthalmia-associated transcription factor 3 69871322, 69895651, 69998131, 70010945, 70068442 AL117653 3p14.2-p14.1 Hs.166017 Hs.618266 93

DNA binding

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

transcription activator activity

transcription activator activity

melanocyte differentiation

Melanogenesis

Pathways in cancer

Melanoma

225108_at 0.545 5.444 2.676 1.709e-02 0.470 -3.010 AGPS alkylglycerone phosphate synthase 2 177965716 BF111719 2q31.2 Hs.516543 19

peroxisome

peroxisomal membrane

cytosol

alkylglycerone-phosphate synthase activity

lipid biosynthetic process

membrane

oxidoreductase activity

transferase activity

FAD binding

Ether lipid metabolism

Metabolic pathways

1552649_a_at 0.405 4.033 2.862 1.175e-02 0.426 -2.693 RFFL ring finger and FYVE-like domain containing 1 17 -30360243, -30360243 NM_057178 17q12 Hs.13680 11

protein binding

cytoplasm

intracellular protein transport

apoptosis

zinc ion binding

membrane

cytoplasmic membrane-bounded vesicle

ligase activity

modification-dependent protein catabolic process

metal ion binding

 
217722_s_at 0.280 11.404 2.660 1.767e-02 0.473 -3.038 NGRN neugrin, neurite outgrowth associated 15 88609898 NM_016645 15q26.1 Hs.715556 Hs.716378 2

molecular_function

nucleus

multicellular organismal development

nervous system development

neuron differentiation

 
235093_at PEX13 peroxisomal biogenesis factor 13 2 61098315 BE564430 2p14-p16 Hs.161377 21

fatty acid alpha-oxidation

neuron migration

suckling behavior

protein binding

membrane fraction

peroxisome

peroxisomal membrane

integral to peroxisomal membrane

locomotory behavior

protein transport

membrane

integral to membrane

protein import into peroxisome matrix, docking

protein import into peroxisome matrix, docking

cerebral cortex cell migration

microtubule-based peroxisome localization

 
217717_s_at 0.360 8.101 2.659 1.771e-02 0.473 -3.040 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 20 42947757 BF246499 20q13.1 Hs.643544 109

cytoplasm

cytosol

protein targeting

Ras protein signal transduction

activation of pro-apoptotic gene products

enzyme binding

protein domain specific binding

negative regulation of protein amino acid dephosphorylation

melanosome

positive regulation of catalytic activity

perinuclear region of cytoplasm

Cell cycle

Neurotrophin signaling pathway

201806_s_at ATXN2L ataxin 2-like 16 28741914, 28741914 NM_007245 16p11 Hs.460499 14

molecular_function

cellular_component

biological_process

membrane

 
200998_s_at 0.266 6.621 2.224 4.167e-02 0.573 -3.754 CKAP4 cytoskeleton-associated protein 4 12 -105155789 AW029619 12q23.3 Hs.714862 Hs.74368 22

membrane fraction

endoplasmic reticulum

membrane

integral to membrane

 
1564383_s_at -0.214 3.139 -2.565 2.139e-02 0.497 -3.199 FLJ35934 FLJ35934 protein 17   AK093253 17p11.2 Hs.375092 2    
209613_s_at -0.938 6.961 -2.459 2.635e-02 0.521 -3.373 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 4 -100446549 M21692 4q21-q23 Hs.4 193

alcohol dehydrogenase (NAD) activity

binding

cytoplasm

ethanol oxidation

zinc ion binding

oxidoreductase activity

metal ion binding

oxidation reduction

Glycolysis / Gluconeogenesis

Fatty acid metabolism

Tyrosine metabolism

1- and 2-Methylnaphthalene degradation

3-Chloroacrylic acid degradation

Retinol metabolism

Metabolism of xenobiotics by cytochrome P450

Drug metabolism - cytochrome P450

Metabolic pathways

235348_at 0.476 4.294 2.812 1.300e-02 0.432 -2.779 ABHD13 abhydrolase domain containing 13 13 107668763 AA404347 13q33.3 Hs.183528 6

membrane

integral to membrane

hydrolase activity

 
213065_at 0.367 6.431 2.972 9.375e-03 0.401 -2.501 ZFC3H1 zinc finger, C3H1-type containing 12 -70289648 AB011118 12q21.1 Hs.527874 4

binding

intracellular

RNA processing

zinc ion binding

metal ion binding

 
203909_at SLC9A6 solute carrier family 9 (sodium/hydrogen exchanger), member 6 X 134895251 NM_006359 Xq26.3 Hs.62185 11

mitochondrion

endosome

endoplasmic reticulum membrane

microsome

plasma membrane

cation transport

sodium ion transport

regulation of pH

antiporter activity

solute:hydrogen antiporter activity

sodium:hydrogen antiporter activity

integral to membrane

sodium ion binding

early endosome membrane

recycling endosome membrane

Cardiac muscle contraction

202753_at 0.284 9.889 3.209 5.774e-03 0.357 -2.089 PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 3 -63971270 NM_014814 3p14.1 Hs.152536 35

proteasome complex

protein binding

cytosol

proteolysis

ATPase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

209681_at -1.283 8.790 -2.848 1.209e-02 0.426 -2.717 SLC19A2 solute carrier family 19 (thiamine transporter), member 2 1 -167699772 AF153330 1q23.3 Hs.30246 32

folic acid binding

cytoplasm

plasma membrane

transport

folic acid transporter activity

reduced folate carrier activity

thiamin transmembrane transporter activity

thiamin transport

integral to membrane

thiamin and derivative metabolic process

 
203820_s_at IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 7 -23316352 NM_006547 7p11 Hs.700696 37

nucleotide binding

RNA binding

nucleus

cytoplasm

anatomical structure morphogenesis

negative regulation of translation

regulation of cytokine biosynthetic process

translation regulator activity

mRNA 5'-UTR binding

 
207169_x_at 1.084 6.635 4.211 7.349e-04 0.211 -0.341 DDR1 discoidin domain receptor tyrosine kinase 1 6 30959839, 30960305, 30964443, 2300465, 2300931, 2305069, 2098794, 2099260, 2103398 NM_001954 6p21.3 Hs.631988 60

nucleotide binding

transmembrane receptor protein tyrosine kinase activity

receptor activity

protein binding

ATP binding

extracellular region

integral to plasma membrane

protein amino acid phosphorylation

cell adhesion

transmembrane receptor protein tyrosine kinase signaling pathway

membrane

transferase activity

 
211045_s_at KCNH6 potassium voltage-gated channel, subfamily H (eag-related), member 6 17 58954426, 58954426 BC006334 17q23.3 Hs.591177 6

voltage-gated ion channel activity

voltage-gated potassium channel activity

regulation of transcription, DNA-dependent

ion transport

potassium ion transport

signal transduction

membrane

integral to membrane

potassium ion binding

 
215932_at -0.223 3.175 -2.234 4.087e-02 0.570 -3.738 MAGEC2 melanoma antigen family C, 2 X -141117795 AL031073 Xq27 Hs.123536 14

nucleus

cytoplasm

 
1552309_a_at 0.317 12.027 2.361 3.199e-02 0.545 -3.535 NEXN nexilin (F actin binding protein) 1 78126787 NM_144573 1p31.1 Hs.612385 6

cytoplasm

cytoskeleton

cell-substrate adherens junction

cell junction

regulation of cell migration

actin filament binding

regulation of cytoskeleton organization

 
214297_at 0.806 4.260 3.878 1.453e-03 0.250 -0.916 CSPG4 chondroitin sulfate proteoglycan 4 15 -73753717 BE857703 15q24.2 Hs.513044 34

angiogenesis

signal transducer activity

receptor signaling protein tyrosine phosphatase signaling protein activity

protein binding

plasma membrane

integral to plasma membrane

signal transduction

multicellular organismal development

receptor signaling protein tyrosine kinase signaling protein activity

cell surface

cell differentiation

cell projection

tissue remodeling

 
212446_s_at LASS6 LAG1 homolog, ceramide synthase 6 2 169021080 AI658534 2q24.3 Hs.506829 Hs.718403 5

transcription factor activity

nucleus

endoplasmic reticulum

regulation of transcription, DNA-dependent

lipid biosynthetic process

membrane

integral to membrane

sphingolipid biosynthetic process

sequence-specific DNA binding

ceramide biosynthetic process

sphingosine N-acyltransferase activity

 
225145_at 0.273 5.687 2.332 3.381e-02 0.552 -3.581 NCOA5 nuclear receptor coactivator 5 20 -44123032 AB046857 20q12-q13.12 Hs.654991 8

aminoacyl-tRNA ligase activity

ATP binding

nucleus

translation

regulation of transcription

 
224832_at DUSP16 dual specificity phosphatase 16 12 -12520097 AB051487 12p13 Hs.536535 12

inactivation of MAPK activity

protein tyrosine phosphatase activity

protein binding

nucleus

cytoplasm

protein amino acid dephosphorylation

hydrolase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

MAPK export from nucleus

MAPK phosphatase export from nucleus, leptomycin B sensitive

MAPK signaling pathway

227766_at LIG4 ligase IV, DNA, ATP-dependent 13 -107657792, -107657792, -107657792 AI829314 13q33-q34 Hs.166091 82

single strand break repair

nucleotide binding

magnesium ion binding

condensed chromosome

in utero embryonic development

pro-B cell differentiation

DNA binding

DNA ligase (ATP) activity

ATP binding

intracellular

nucleus

cytoplasm

plasma membrane

focal adhesion

DNA-dependent protein kinase-DNA ligase 4 complex

DNA replication

nucleotide-excision repair, DNA gap filling

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

response to DNA damage stimulus

cell cycle

central nervous system development

protein C-terminus binding

cell proliferation

response to X-ray

response to gamma radiation

ligase activity

provirus integration

initiation of viral infection

DNA ligase IV complex

DNA ligase IV complex

T cell differentiation in the thymus

immunoglobulin V(D)J recombination

T cell receptor V(D)J recombination

somatic stem cell maintenance

negative regulation of neuron apoptosis

isotype switching

positive regulation of fibroblast proliferation

positive regulation of neurogenesis

DNA ligation during DNA recombination

DNA ligation during DNA repair

DNA ligation during DNA repair

chromosome organization

cell division

Non-homologous end-joining

209508_x_at 0.516 7.396 3.600 2.576e-03 0.287 -1.402 CFLAR CASP8 and FADD-like apoptosis regulator 2 201689060, 201689134, 201691631 AF005774 2q33-q34 Hs.390736 163

cysteine-type endopeptidase activity

protein binding

proteolysis

anti-apoptosis

induction of apoptosis by extracellular signals

regulation of apoptosis

positive regulation of I-kappaB kinase/NF-kappaB cascade

interspecies interaction between organisms

Apoptosis

208865_at 0.275 9.179 2.138 4.910e-02 0.590 -3.889 CSNK1A1 casein kinase 1, alpha 1 5 -148855037 BG534245 5q32 Hs.529862 Hs.712555 53

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

cytosol

protein amino acid phosphorylation

Wnt receptor signaling pathway

transferase activity

Wnt signaling pathway

Hedgehog signaling pathway

213546_at 0.552 6.584 2.407 2.925e-02 0.535 -3.460 DKFZP586I1420 hypothetical protein DKFZp586I1420 7 30376190 AL050378 7p14.3 Hs.112423 2    
202222_s_at 0.273 11.468 2.285 3.705e-02 0.562 -3.657 DES desmin 2 219991342 NM_001927 2q35 Hs.594952 57

structural constituent of cytoskeleton

protein binding

intracellular

insoluble fraction

cytoplasm

cytoskeleton

muscle contraction

cytoskeleton organization

regulation of heart contraction

Z disc

sarcolemma

contractile fiber

type III intermediate filament

synapse

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

202590_s_at -0.355 8.502 -2.421 2.842e-02 0.532 -3.436 PDK2 pyruvate dehydrogenase kinase, isozyme 2 17 45527694 AL574319 17q21.33 Hs.256667 28

two-component sensor activity

nucleotide binding

pyruvate dehydrogenase (acetyl-transferring) kinase activity

protein binding

ATP binding

nucleus

nucleolus

mitochondrion

mitochondrial matrix

carbohydrate metabolic process

glucose metabolic process

signal transduction

transferase activity

peptidyl-histidine phosphorylation

 
219882_at 0.447 5.188 2.770 1.417e-02 0.445 -2.851 TTLL7 tubulin tyrosine ligase-like family, member 7 1 -84107644 NM_024686 1p31.1 Hs.445826 7

tubulin-tyrosine ligase activity

cilium

microtubule basal body

protein modification process

multicellular organismal development

nervous system development

ligase activity

cell differentiation

dendrite

perikaryon

 
204745_x_at 0.877 8.513 4.749 2.490e-04 0.172 0.563 MT1G metallothionein 1G 16 -55258153 NM_005950 16q13 Hs.433391 17

copper ion binding

protein binding

zinc ion binding

cadmium ion binding

metal ion binding

 
206662_at 0.901 9.632 4.386 5.156e-04 0.204 -0.043 GLRX glutaredoxin (thioltransferase) 5 -95175308 NM_002064 5q14 Hs.28988 Hs.712696 47

cytoplasm

cytosol

transport

electron carrier activity

protein disulfide oxidoreductase activity

glutathione disulfide oxidoreductase activity

electron transport chain

cell redox homeostasis

protein N-terminus binding

 
209841_s_at 1.195 4.453 3.052 7.965e-03 0.384 -2.363 LRRN3 leucine rich repeat neuronal 3 7 110518297 AL442092 7q31.1 Hs.3781 6

protein binding

membrane

integral to membrane

 
1563743_at -0.335 3.552 -3.315 4.637e-03 0.335 -1.903 C1orf180 chromosome 1 open reading frame 180 1 -84866500 AK092806 1p22.3 Hs.407054 2    
37170_at 0.410 3.934 2.954 9.734e-03 0.407 -2.533 BMP2K BMP2 inducible kinase 4 79916555, 79916555 AB015331 4q21.21 Hs.146551 11

nucleotide binding

protein serine/threonine kinase activity

ATP binding

nucleus

protein amino acid phosphorylation

transferase activity

 
1552301_a_at 0.519 10.094 2.927 1.028e-02 0.417 -2.579 CORO6 coronin 6 17 -24965899 NM_032854 17q11.2 Hs.143046 7    
208818_s_at 0.431 8.197 2.238 4.055e-02 0.570 -3.732 COMT catechol-O-methyltransferase 22 18309262, 18318459, 18319044, 18330069 BC000419 22q11.21 22q11.21-q11.23 Hs.370408 Hs.704514 Hs.713616 742

magnesium ion binding

protein binding

soluble fraction

cytoplasm

microsome

cytosol

plasma membrane

catecholamine metabolic process

integral to membrane

catechol O-methyltransferase activity

catechol O-methyltransferase activity

transferase activity

neurotransmitter catabolic process

dopamine catabolic process

Tyrosine metabolism

Betalain biosynthesis

Metabolic pathways

214948_s_at 0.432 6.648 2.680 1.697e-02 0.469 -3.004 TMF1 TATA element modulatory factor 1 3 -69151667 AL050136 3p21-p12 Hs.267632 15

Golgi membrane

DNA binding

RNA polymerase II transcription factor activity

transcription cofactor activity

protein binding

nucleus

cytoplasm

Golgi apparatus

regulation of transcription, DNA-dependent

transcription from RNA polymerase II promoter

membrane

 
224735_at 0.284 6.439 2.236 4.078e-02 0.570 -3.736 CYBASC3 cytochrome b, ascorbate dependent 3 11 -60872797, -60872797 AA683481 11q12.2 Hs.22546 8

iron ion binding

lysosome

endosome

transport

membrane

integral to membrane

oxidoreductase activity

electron transport chain

metal ion binding

 
237094_at 0.661 2.970 5.046 1.389e-04 0.169 1.043 FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 22 47263951, 47350781 AI953086 22q13.32 Hs.436854 Hs.632788 8

extracellular region

membrane

integral to membrane

 
232051_at CCDC102A coiled-coil domain containing 102A 16 -56103592 BC004307 16q21 Hs.644611 2    
223145_s_at 0.599 8.565 3.759 1.856e-03 0.271 -1.124 AKIRIN2 akirin 2 6 -88441298 BC000764 6q15 Hs.485915 10

protein binding

nucleus

embryonic development

transcriptional repressor complex

response to lipopolysaccharide

positive regulation of interleukin-6 production

innate immune response

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

 
228306_at CNIH4 cornichon homolog 4 (Drosophila) 1 222611217 T87074 1q42.11 Hs.195403 Hs.445890 11

protein binding

endoplasmic reticulum

intracellular signaling cascade

membrane

integral to membrane

 
225029_at 0.824 6.807 4.238 6.960e-04 0.211 -0.295 LOC550643 hypothetical LOC550643 X 56772442 BE621082 Xp11.1 Hs.355559 1    
222222_s_at 0.780 6.876 3.691 2.134e-03 0.276 -1.242 HOMER3 homer homolog 3 (Drosophila) 19 -18901009, -18901009, -18901009, -18901009, -18901009 AC002985 19p13.11 Hs.10326 16

protein binding

cytoplasm

plasma membrane

protein targeting

metabotropic glutamate receptor signaling pathway

postsynaptic density

cell junction

synapse

postsynaptic membrane

 
208840_s_at G3BP2 GTPase activating protein (SH3 domain) binding protein 2 4 -76786976, -76786976 AU149503 4q21.1 Hs.303676 15

nucleotide binding

RNA binding

protein binding

intracellular

cytoplasm

transport

cytoplasmic sequestering of NF-kappaB

Ras protein signal transduction

receptor signaling complex scaffold activity

mRNA transport

 
202179_at 0.485 6.492 4.817 2.175e-04 0.172 0.675 BLMH bleomycin hydrolase 17 -25599348 NM_000386 17q11.2 Hs.371914 27

aminopeptidase activity

carboxypeptidase activity

cysteine-type endopeptidase activity

soluble fraction

nucleus

cytoplasm

proteolysis

peptidase activity

response to toxin

response to drug

 
242274_x_at -0.579 4.133 -3.537 2.932e-03 0.298 -1.512 SLC25A42 solute carrier family 25, member 42 19 19035807 AI057363 19p13.11 Hs.303669 3

binding

mitochondrion

mitochondrial inner membrane

transport

membrane

integral to membrane

 
222576_s_at EIF2C1 eukaryotic translation initiation factor 2C, 1 1 36121396 AW071829 1p35-p34 Hs.22867 26

cytoplasmic mRNA processing body

nuclear-transcribed mRNA catabolic process

RNA binding

protein binding

cytoplasm

regulation of translation

gene silencing by RNA

gene silencing by miRNA, negative regulation of translation

regulation of transcription

 
223063_at 0.408 7.243 2.990 9.053e-03 0.396 -2.472 C1orf198 chromosome 1 open reading frame 198 1 -229039487, -229039487, -229039487 BC004870 1q42.13-q43 Hs.520494 6    
223165_s_at 0.670 6.905 2.580 2.074e-02 0.497 -3.173 IP6K2 inositol hexakisphosphate kinase 2 3 -48705886, -48700439 BC004469 3p21.31 Hs.595983 18

nucleotide binding

inositol or phosphatidylinositol kinase activity

ATP binding

nucleus

cytoskeleton

inositol trisphosphate 3-kinase activity

transferase activity

negative regulation of cell growth

positive regulation of apoptosis

phosphoinositide phosphorylation

 
209283_at 0.345 12.678 2.538 2.256e-02 0.501 -3.243 CRYAB crystallin, alpha B 11 -111284559 AF007162 11q22.3-q23.1 Hs.408767 143

structural constituent of eye lens

soluble fraction

insoluble fraction

cytoplasm

plasma membrane

protein folding

anti-apoptosis

muscle contraction

muscle organ development

response to heat

Z disc

negative regulation of intracellular transport

camera-type eye development

contractile fiber

unfolded protein binding

protein homooligomerization

 
213387_at ATAD2B ATPase family, AAA domain containing 2B 2 -23825037 AB033066 2p24.1-p23.3 Hs.467862 5

nucleotide binding

ATP binding

nucleoside-triphosphatase activity

 
228670_at TEP1 telomerase-associated protein 1 14 -19903666 BF197089 14q11.2 Hs.508835 19

nucleotide binding

telomere maintenance via recombination

chromosome, telomeric region

telomerase activity

RNA binding

ATP binding

soluble fraction

nucleus

chromosome

telomerase holoenzyme complex

cytoplasm

nuclear matrix

 
212202_s_at 0.414 7.231 2.846 1.215e-02 0.426 -2.721 TMEM87A transmembrane protein 87A 15 -40337427, -40290017 BG493972 15q15.1 Hs.511138 Hs.719196 6

membrane

integral to membrane

 
223228_at 0.559 7.426 3.333 4.465e-03 0.331 -1.870 LDOC1L leucine zipper, down-regulated in cancer 1-like 22 -43267113 AL136553 22q13.31 Hs.715637 6    
203884_s_at 0.302 6.039 3.257 5.227e-03 0.348 -2.005 RAB11FIP2 RAB11 family interacting protein 2 (class I) 10 -119754418 NM_014904 10q26.11 Hs.173656 20

protein binding

endosome

plasma membrane

protein transport

Endocytosis

218076_s_at 0.350 7.620 2.467 2.597e-02 0.518 -3.361 ARHGAP17 Rho GTPase activating protein 17 16 -24838212 NM_018054 16p12.1 Hs.373793 8

GTPase activator activity

protein binding

intracellular

cytoplasm

tight junction

signal transduction

membrane

SH3 domain binding

cell junction

 
238799_at 0.306 3.277 2.527 2.306e-02 0.505 -3.262 ATP5S ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) 14 49848796, 49848796 BE968806 14q21.3 Hs.438489 12

mitochondrion

mitochondrial inner membrane

ATP biosynthetic process

ion transport

hydrogen ion transmembrane transporter activity

proton transport

membrane

proton-transporting ATP synthase complex, coupling factor F(o)

 
1562017_at LOC100130654 hypothetical protein LOC100130654 17   AK095243 17q21.2 Hs.636509 1    
223654_s_at BRUNOL4 bruno-like 4, RNA binding protein (Drosophila) 18 -33077005 BC004167 18q12 Hs.435976 Hs.600908 12

nucleotide binding

regulation of alternative nuclear mRNA splicing, via spliceosome

translation repressor activity, nucleic acid binding

nucleus

cytoplasm

germ cell development

embryonic development

BRE binding

 
225033_at 0.449 6.709 3.037 8.212e-03 0.387 -2.389 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 8 -134536272 AV721528 8q24.22 Hs.374257 20

beta-galactoside alpha-2,3-sialyltransferase activity

extracellular region

Golgi apparatus

protein amino acid glycosylation

membrane

integral to membrane

integral to Golgi membrane

O-Glycan biosynthesis

Keratan sulfate biosynthesis

Glycosphingolipid biosynthesis - globo series

Glycosphingolipid biosynthesis - ganglio series

Metabolic pathways

202756_s_at 0.497 7.856 3.172 6.230e-03 0.362 -2.154 GPC1 glypican 1 2 241023787 NM_002081 2q35-q37 Hs.328232 29

extracellular region

proteinaceous extracellular matrix

extracellular space

plasma membrane

integral to plasma membrane

anchored to membrane

heparan sulfate proteoglycan binding

 
236250_at 0.389 5.927 3.697 2.106e-03 0.276 -1.231 AFG3L1 AFG3 ATPase family gene 3-like 1 (S. cerevisiae) 16 88566488, 88566488 AI859065 16q24.3 Hs.534773 6    
214541_s_at 0.671 5.840 3.709 2.058e-03 0.274 -1.211 QKI quaking homolog, KH domain RNA binding (mouse) 6 163755664, 163755664 AF142418 6q26 6q26-q27 Hs.510324 Hs.593520 23

RNA binding

protein binding

nucleus

nucleolus

cytoplasm

plasma membrane

mRNA processing

regulation of translation

transport

multicellular organismal development

RNA splicing

SH3 domain binding

cell differentiation

mRNA transport

 
223402_at DUSP23 dual specificity phosphatase 23 1 158017382 BC001140 1q23.2 Hs.425801 7

protein tyrosine phosphatase activity

nucleus

cytoplasm

cytosol

protein amino acid dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

hydrolase activity

 
235549_at 0.644 4.321 2.494 2.462e-02 0.513 -3.317 RNF144B ring finger protein 144B 6 18495572 AL575512 6p22.3 Hs.148741 6

ubiquitin ligase complex

ubiquitin-protein ligase activity

protein binding

apoptosis

zinc ion binding

membrane

integral to membrane

ligase activity

modification-dependent protein catabolic process

protein ubiquitination during ubiquitin-dependent protein catabolic process

metal ion binding

 
212062_at 0.512 7.052 2.958 9.660e-03 0.406 -2.527 ATP9A ATPase, class II, type 9A 20 -49646720 AB014511 20q13.2 Hs.719117 6

nucleotide binding

magnesium ion binding

phospholipid-translocating ATPase activity

ATP binding

ATP biosynthetic process

metabolic process

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

phospholipid transport

membrane

integral to membrane

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

 
225365_at 0.316 5.561 2.305 3.566e-02 0.556 -3.625 ZDHHC20 zinc finger, DHHC-type containing 20 13 -20848507 BG249221 13q12.11 Hs.564611 Hs.693749 4

zinc ion binding

acyltransferase activity

membrane

integral to membrane

transferase activity

metal ion binding

 
233328_x_at -0.339 5.249 -3.460 3.440e-03 0.308 -1.648 SLC17A9 solute carrier family 17, member 9 20 61054443 AL121673 20q13.33 Hs.512686 7

transporter activity

transport

exocytosis

membrane

integral to membrane

 
202157_s_at 0.315 8.230 2.225 4.161e-02 0.573 -3.753 CUGBP2 CUG triplet repeat, RNA binding protein 2 10 11087264, 11099898, 11246998 U69546 10p13 Hs.309288 25

nucleotide binding

RNA binding

protein binding

nucleus

cytoplasm

mRNA processing

regulation of heart contraction

 
225996_at 0.376 7.455 2.278 3.758e-02 0.564 -3.669 LONRF2 LON peptidase N-terminal domain and ring finger 2 2 -100256184 AV709727 2q11.2 Hs.21380 4

ATP-dependent peptidase activity

protein binding

proteolysis

zinc ion binding

metal ion binding

 
235103_at 0.551 6.297 2.413 2.886e-02 0.534 -3.449 MAN2A1 mannosidase, alpha, class 2A, member 1 5 109053054 AA029155 5q21-q22 Hs.432822 29

Golgi membrane

in utero embryonic development

liver development

alpha-mannosidase activity

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

Golgi apparatus

carbohydrate metabolic process

mannose metabolic process

N-glycan processing

mitochondrion organization

vacuole organization

respiratory gaseous exchange

metabolic process

zinc ion binding

membrane

integral to membrane

hydrolase activity, hydrolyzing N-glycosyl compounds

carbohydrate binding

metal ion binding

lung alveolus development

N-Glycan biosynthesis

Metabolic pathways

228194_s_at SORCS1 sortilin-related VPS10 domain containing receptor 1 10 -108323410 AI675836 10q23-q25 Hs.591915 8

protein binding

protein binding

neuropeptide signaling pathway

neuropeptide receptor activity

membrane

integral to membrane

 
223422_s_at 1.254 6.120 3.737 1.940e-03 0.273 -1.162 ARHGAP24 Rho GTPase activating protein 24 4 86615307, 86918874, 87070449 AI743534 4q21.23-q21.3 Hs.444229 14

angiogenesis

GTPase activator activity

protein binding

intracellular

cytoplasm

cytoskeleton

adherens junction

focal adhesion

signal transduction

multicellular organismal development

cell junction

cell differentiation

cell projection

 
242917_at RASGEF1A RasGEF domain family, member 1A 10 -43009989 AI884701 10q11.21 Hs.125293 4

guanyl-nucleotide exchange factor activity

intracellular

regulation of small GTPase mediated signal transduction

 
201387_s_at 0.888 7.216 2.272 3.803e-02 0.565 -3.678 UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 4 40953654 NM_004181 4p14 Hs.518731 94

cysteine-type endopeptidase activity

ubiquitin thiolesterase activity

protein binding

intracellular

nucleus

nucleolus

cytoplasm

cytoplasm

cytosol

ubiquitin-dependent protein catabolic process

response to stress

axon target recognition

adult walking behavior

peptidase activity

omega peptidase activity

cell proliferation

protein deubiquitination

ligase activity

axon transport of mitochondrion

axon

eating behavior

cell soma

ubiquitin binding

neuromuscular process

Parkinson's disease

243_g_at 0.453 9.788 2.412 2.893e-02 0.534 -3.451 MAP4 microtubule-associated protein 4 3 -47989573, -47867183, -47867183 M64571 3p21 Hs.517949 40

structural molecule activity

protein binding

microtubule

microtubule associated complex

negative regulation of microtubule depolymerization

 
203098_at CDYL chromodomain protein, Y-like 6 4651391, 4721678, 4781330, 4835224 AL050164 6p25.1 Hs.269092 8

chromatin

chromatin binding

histone acetyltransferase activity

nucleus

chromatin assembly or disassembly

spermatogenesis

metabolic process

acyltransferase activity

transferase activity

regulation of transcription

 
211036_x_at 0.316 9.183 2.408 2.917e-02 0.535 -3.458 ANAPC5 anaphase promoting complex subunit 5 12 -120230432, -120230432 BC006301 12q24.31 Hs.7101 28

G2/M transition of mitotic cell cycle

mitotic anaphase

ubiquitin-protein ligase activity

binding

nucleoplasm

anaphase-promoting complex

cytosol

ubiquitin-dependent protein catabolic process

cell cycle

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

cell division

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Cell cycle

Ubiquitin mediated proteolysis

226317_at PPP4R2 protein phosphatase 4, regulatory subunit 2 3 73128808 AI983837 3p13 Hs.431092 7

protein binding

centrosome

mRNA processing

protein modification process

RNA splicing

 
235593_at 0.906 3.420 3.402 3.876e-03 0.319 -1.750 ZEB2 zinc finger E-box binding homeobox 2 2 -144862052 AL546529 2q22.3 Hs.34871 49

transcription factor activity

intracellular

nucleus

regulation of transcription, DNA-dependent

nervous system development

zinc ion binding

negative regulation of transcription

phosphatase regulator activity

sequence-specific DNA binding

SMAD binding

metal ion binding

 
227394_at 0.769 5.756 3.458 3.450e-03 0.308 -1.651 NCAM1 neural cell adhesion molecule 1 11 112337204, 112337204 W94001 11q23.1 Hs.503878 120

protein binding

extracellular region

plasma membrane

cell adhesion

integral to membrane

anchored to membrane

Cell adhesion molecules (CAMs)

Prion diseases

206289_at -0.450 6.561 -2.876 1.142e-02 0.426 -2.669 HOXA4 homeobox A4 7 -27134650 NM_002141 7p15-p14 Hs.533357 Hs.714774 22

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

anatomical structure morphogenesis

anterior/posterior pattern formation

sequence-specific DNA binding

embryonic skeletal system morphogenesis

 
223852_s_at 0.603 7.293 4.025 1.074e-03 0.227 -0.661 STK40 serine/threonine kinase 40 1 -36577811 BC005169 1p34.3 Hs.471768 11

nucleotide binding

protein serine/threonine kinase activity

ATP binding

nucleus

cytoplasm

protein amino acid phosphorylation

transferase activity

 
219390_at FKBP14 FK506 binding protein 14, 22 kDa 7 -30019408 NM_017946 7p14.3 Hs.571333 7

peptidyl-prolyl cis-trans isomerase activity

calcium ion binding

endoplasmic reticulum

endoplasmic reticulum lumen

protein folding

isomerase activity

 
226127_at 0.321 7.177 2.253 3.947e-02 0.567 -3.709 ALKBH3 alkB, alkylation repair homolog 3 (E. coli) 11 43858932 BF062547 11p11.2 Hs.368920 11

damaged DNA binding

iron ion binding

nucleus

nucleoplasm

cytoplasm

mitochondrion

DNA repair

response to DNA damage stimulus

oxidoreductase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

L-ascorbic acid binding

metal ion binding

oxidation reduction

 
224788_at ARF6 ADP-ribosylation factor 6 14 49429485 AV700721 14q21.3 Hs.525330 Hs.682124 86

nucleotide binding

ruffle

liver development

GTPase activity

protein binding

GTP binding

intracellular

membrane fraction

cytoplasm

endosome

Golgi apparatus

plasma membrane

cell cortex

apoptosis

cell motion

cell adhesion

small GTPase mediated signal transduction

protein transport

vesicle-mediated transport

positive regulation of actin filament polymerization

cortical actin cytoskeleton organization

ruffle organization

regulation of Rac protein signal transduction

negative regulation of receptor-mediated endocytosis

Endocytosis

Fc gamma R-mediated phagocytosis

210622_x_at CDK10 cyclin-dependent kinase 10 16 88280576 AF153430 16q24 Hs.699177 16

nucleotide binding

cyclin-dependent protein kinase activity

protein binding

ATP binding

protein amino acid phosphorylation

traversing start control point of mitotic cell cycle

negative regulation of cell proliferation

transferase activity

 
218464_s_at C17orf63 chromosome 17 open reading frame 63 17 -24107122 NM_018182 17q11.2 Hs.564533 4    
203359_s_at MYCBP c-myc binding protein 1 -39101222 AL525412 1p33-p32.2 Hs.591506 12

transcription coactivator activity

protein binding

nucleus

cytoplasm

mitochondrion

spermatogenesis

regulation of transcription

 
219024_at 0.550 6.599 2.761 1.442e-02 0.447 -2.866 PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 10 124124209, 124141832 NM_021622 10q26.13 Hs.643512 16

phospholipid binding

cellular_component

nucleus

cytoplasm

plasma membrane

biological_process

 
1553367_a_at -0.394 4.957 -3.385 4.016e-03 0.323 -1.780 COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) 19 -60552881 NM_144613 19q13.42 Hs.550544 5

cytochrome-c oxidase activity

mitochondrion

mitochondrial intermembrane space

mitochondrial crista

Oxidative phosphorylation

Metabolic pathways

Cardiac muscle contraction

Alzheimer's disease

Parkinson's disease

Huntington's disease

204681_s_at RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 7 -22124432 NM_012294 7p15.3 Hs.174768 Hs.713217 10

intracellular

nucleus

nervous system development

Rap guanyl-nucleotide exchange factor activity

GTP-dependent protein binding

regulation of small GTPase mediated signal transduction

 
222658_s_at 0.307 6.310 3.169 6.270e-03 0.363 -2.159 APTX aprataxin 9 -32962607, -32962607, -32962607, -32962607, -32962607 BC001628 9p13.3 Hs.20158 41

single strand break repair

chromatin

chromatin binding

damaged DNA binding

double-stranded DNA binding

double-stranded RNA binding

intracellular

nucleus

nucleoplasm

nucleolus

response to DNA damage stimulus

cell death

zinc ion binding

phosphoglycolate phosphatase activity

hydrolase activity

regulation of protein stability

DNA 5'-adenosine monophosphate hydrolase activity

response to hydrogen peroxide

metal ion binding

protein N-terminus binding

 
212978_at LRRC8B leucine rich repeat containing 8 family, member B 1 89762984, 89796859 AU146004 1p22.2 Hs.482017 Hs.632420 6

protein binding

membrane

integral to membrane

 
206208_at CA4 carbonic anhydrase IV 17 55582083 NM_000717 17q23 Hs.89485 30

carbonate dehydratase activity

membrane fraction

plasma membrane

one-carbon metabolic process

visual perception

zinc ion binding

lyase activity

anchored to membrane

metal ion binding

response to stimulus

Nitrogen metabolism

242268_at CUGBP2 CUG triplet repeat, RNA binding protein 2 10 11087264, 11099898, 11246998 BE157991 10p13 Hs.309288 25

nucleotide binding

RNA binding

protein binding

nucleus

cytoplasm

mRNA processing

regulation of heart contraction

 
203787_at 0.697 7.330 3.660 2.275e-03 0.279 -1.297 SSBP2 single-stranded DNA binding protein 2 5 -80751427 NM_012446 5q14.1 Hs.102735 14

DNA binding

single-stranded DNA binding

protein binding

nucleus

cytoplasm

transcription regulator activity

regulation of transcription

 
206703_at 0.882 6.822 4.199 7.535e-04 0.211 -0.362 CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 17 7289129 NM_000747 17p13.1 Hs.330386 20

postsynaptic membrane organization

nicotinic acetylcholine-activated cation-selective channel activity

extracellular ligand-gated ion channel activity

protein binding

plasma membrane

nicotinic acetylcholine-gated receptor-channel complex

cation transport

muscle contraction

signal transduction

synaptic transmission, cholinergic

neuromuscular synaptic transmission

channel activity

acetylcholine receptor activity

cell junction

behavioral response to nicotine

regulation of membrane potential

synapse

postsynaptic membrane

muscle fiber development

neurological system process

 
206263_at 0.583 4.371 4.841 2.075e-04 0.172 0.713 FMO4 flavin containing monooxygenase 4 1 169550109 NM_002022 1q23-q25 Hs.386502 11

monooxygenase activity

flavin-containing monooxygenase activity

endoplasmic reticulum

microsome

xenobiotic metabolic process

membrane

integral to membrane

intrinsic to endoplasmic reticulum membrane

FAD binding

NADP or NADPH binding

oxidation reduction

Drug metabolism - cytochrome P450

211039_at 1.969 4.739 3.130 6.786e-03 0.368 -2.227 CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2 -175320568 BC006314 2q24-q32 Hs.434479 43

skeletal muscle contraction

nicotinic acetylcholine-activated cation-selective channel activity

ion channel activity

extracellular ligand-gated ion channel activity

plasma membrane

nicotinic acetylcholine-gated receptor-channel complex

ion transport

signal transduction

neuromuscular synaptic transmission

neuromuscular junction development

cell surface

acetylcholine receptor activity

integral to membrane

regulation of action potential in neuron

cell junction

neuromuscular junction

regulation of membrane potential

postsynaptic membrane

muscle maintenance

skeletal muscle tissue growth

neuromuscular process

neuron maintenance

 
217944_at POMGNT1 protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase 1 -46426940, -46426940 NM_017739 1p34.1 Hs.525134 24

Golgi membrane

alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

microsome

Golgi apparatus

protein amino acid N-linked glycosylation

protein amino acid O-linked glycosylation

membrane

integral to membrane

transferase activity, transferring glycosyl groups

manganese ion binding

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity

O-Mannosyl glycan biosynthesis

230076_at 0.222 3.351 2.144 4.862e-02 0.590 -3.881 PITPNM3 PITPNM family member 3 17 -6295306 BF063164 17p13 Hs.183983 5

calcium ion binding

intracellular

transport

visual perception

lipid binding

phosphatidylinositol transporter activity

membrane

integral to membrane

phosphoinositide metabolic process

receptor tyrosine kinase binding

response to stimulus

 
208649_s_at 0.447 8.396 4.162 8.124e-04 0.214 -0.425 VCP valosin-containing protein 9 -35046064 AF100752 9p13.3 Hs.529782 97

nucleotide binding

ATP binding

nucleus

nucleus

nucleolus

cytoplasm

endoplasmic reticulum

microsome

cytosol

double-strand break repair

transport

activation of caspase activity

response to DNA damage stimulus

lipid binding

protein ubiquitination

hydrolase activity

ATPase activity

protein domain specific binding

modification-dependent protein catabolic process

ER-associated protein catabolic process

endoplasmic reticulum unfolded protein response

retrograde protein transport, ER to cytosol

regulation of apoptosis

establishment of protein localization

 
218071_s_at 0.432 7.148 4.355 5.481e-04 0.207 -0.095 MKRN2 makorin ring finger protein 2 3 12573593 NM_014160 3p25 Hs.591666 5

molecular_function

nucleic acid binding

protein binding

intracellular

biological_process

zinc ion binding

metal ion binding

 
224793_s_at TGFBR1 transforming growth factor, beta receptor 1 9 100907232, 100907232 AA604375 9q22 Hs.494622 202

nucleotide binding

activation of MAPKK activity

magnesium ion binding

in utero embryonic development

kidney development

protein serine/threonine kinase activity

receptor activity

transforming growth factor beta receptor activity, type I

type II transforming growth factor beta receptor binding

type II transforming growth factor beta receptor binding

ATP binding

signal transduction

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

heart development

positive regulation of cell proliferation

germ cell migration

anterior/posterior pattern formation

positive regulation of pathway-restricted SMAD protein phosphorylation

integral to membrane

transferase activity

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

manganese ion binding

collagen fibril organization

positive regulation of cell growth

positive regulation of survival gene product expression

positive regulation of transcription

SMAD binding

protein heterodimerization activity

thymus development

neuron fate commitment

embryonic cranial skeleton morphogenesis

skeletal system morphogenesis

artery morphogenesis

cell motility

transforming growth factor beta binding

positive regulation of cell motion

positive regulation of protein kinase B signaling cascade

parathyroid gland development

palate development

pharyngeal system development

positive regulation of SMAD protein nuclear translocation

transforming growth factor beta receptor complex

response to cholesterol

MAPK signaling pathway

Cytokine-cytokine receptor interaction

Endocytosis

TGF-beta signaling pathway

Adherens junction

Pathways in cancer

Colorectal cancer

Pancreatic cancer

Chronic myeloid leukemia

225735_at ANKRD50 ankyrin repeat domain 50 4 -125804915 AL110131 4q28.1 Hs.480694 3    
239660_at C20orf74 chromosome 20 open reading frame 74 20 -20321410 BF110518 20p11.22 Hs.472285 4

GTPase activator activity

intracellular

cytoplasm

regulation of small GTPase mediated signal transduction

 
202670_at MAP2K1 mitogen-activated protein kinase kinase 1 15 64466264 AI571419 15q22.1-q22.33 Hs.145442 171

nucleotide binding

protein serine/threonine kinase activity

MAP kinase kinase activity

protein tyrosine kinase activity

receptor signaling protein tyrosine phosphatase activity

protein binding

ATP binding

Golgi apparatus

cytosol

protein amino acid phosphorylation

cell motion

chemotaxis

response to oxidative stress

mitosis

Ras protein signal transduction

cell proliferation

transferase activity

neuron differentiation

keratinocyte differentiation

positive regulation of MAP kinase activity

positive regulation of cell differentiation

response to glucocorticoid stimulus

MAPK signaling pathway

ErbB signaling pathway

Chemokine signaling pathway

Vascular smooth muscle contraction

Dorso-ventral axis formation

VEGF signaling pathway

Focal adhesion

Gap junction

Toll-like receptor signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Fc gamma R-mediated phagocytosis

Long-term potentiation

Neurotrophin signaling pathway

Long-term depression

Regulation of actin cytoskeleton

Insulin signaling pathway

GnRH signaling pathway

Melanogenesis

Prion diseases

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Endometrial cancer

Glioma

Prostate cancer

Thyroid cancer

Melanoma

Bladder cancer

Chronic myeloid leukemia

Acute myeloid leukemia

Non-small cell lung cancer

235068_at ZDHHC21 zinc finger, DHHC-type containing 21 9 -14607032 AI807206 9p22.3 Hs.649522 4

zinc ion binding

acyltransferase activity

membrane

integral to membrane

transferase activity

metal ion binding

 
224149_x_at 0.571 6.677 2.623 1.905e-02 0.489 -3.101 SLMAP sarcolemma associated protein 3 57718213 AF304450 3p21.2-p14.3 Hs.476432 11

smooth endoplasmic reticulum

plasma membrane

integral to plasma membrane

protein folding

muscle contraction

prefoldin complex

unfolded protein binding

 
209645_s_at 0.790 5.820 3.229 5.534e-03 0.353 -2.053 ALDH1B1 aldehyde dehydrogenase 1 family, member B1 9 38382701 NM_000692 9p11.1 Hs.436219 15

aldehyde dehydrogenase (NAD) activity

mitochondrion

mitochondrial matrix

carbohydrate metabolic process

oxidoreductase activity

oxidation reduction

Glycolysis / Gluconeogenesis

Ascorbate and aldarate metabolism

Fatty acid metabolism

Valine, leucine and isoleucine degradation

Lysine degradation

Arginine and proline metabolism

Histidine metabolism

Tryptophan metabolism

beta-Alanine metabolism

Glycerolipid metabolism

Pyruvate metabolism

Propanoate metabolism

3-Chloroacrylic acid degradation

Butanoate metabolism

Limonene and pinene degradation

Metabolic pathways

213434_at 0.370 6.097 2.673 1.721e-02 0.471 -3.016 STX2 syntaxin 2 12 -129840099 H95263 12q24.33 Hs.437585 28

SNARE binding

cytokinesis

cell separation during cytokinesis

SNAP receptor activity

membrane fraction

soluble fraction

endosome

microsome

plasma membrane

intracellular protein transport

signal transduction

acrosome reaction

ectoderm development

organ morphogenesis

integral to membrane

vesicle-mediated transport

basolateral plasma membrane

apical plasma membrane

microvillus assembly

midbody

epithelial cell differentiation

plasma membrane fusion

calcium-dependent protein binding

gut morphogenesis

SNARE interactions in vesicular transport

205914_s_at GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 9 139153429 NM_007327 9q34.3 Hs.558334 119

magnesium ion binding

receptor activity

N-methyl-D-aspartate selective glutamate receptor activity

ion channel activity

extracellular-glutamate-gated ion channel activity

calcium channel activity

calcium ion binding

calmodulin binding

plasma membrane

integral to plasma membrane

cation transport

synaptic transmission

synaptic vesicle

visual learning

postsynaptic density

glycine binding

glycine binding

glutamate binding

N-methyl-D-aspartate selective glutamate receptor complex

synaptosome

cell junction

dendrite

ionotropic glutamate receptor signaling pathway

glutamate receptor binding

regulation of membrane potential

synapse

postsynaptic membrane

response to ethanol

positive regulation of transcription from RNA polymerase II promoter

calcium ion homeostasis

regulation of excitatory postsynaptic membrane potential

Calcium signaling pathway

Neuroactive ligand-receptor interaction

Long-term potentiation

Alzheimer's disease

Amyotrophic lateral sclerosis (ALS)

Huntington's disease

212055_at C18orf10 chromosome 18 open reading frame 10 18 -32630031 BF689173 18q12.2 Hs.695999 5

cytoplasm

cytoskeleton

microtubule

 
227038_at SGMS2 sphingomyelin synthase 2 4 108965169, 109033868 AI963083 4q25 Hs.595423 13

Golgi apparatus

plasma membrane

integral to plasma membrane

lipid metabolic process

sphingolipid metabolic process

sphingomyelin biosynthetic process

kinase activity

transferase activity

integral to Golgi membrane

sphingomyelin synthase activity

ceramide cholinephosphotransferase activity

Sphingolipid metabolism

Metabolic pathways

212002_at 0.287 7.210 2.853 1.195e-02 0.426 -2.707 C1orf144 chromosome 1 open reading frame 144 1 16566169 AL561657 1p36.13 Hs.252967 2    
225320_at 0.426 7.973 2.144 4.855e-02 0.590 -3.880 CCDC109A coiled-coil domain containing 109A 10 74121894 AA579630 10q22.1 Hs.591366 2

membrane

integral to membrane

 
217728_at 1.369 8.584 2.991 9.027e-03 0.396 -2.469 S100A6 S100 calcium binding protein A6 1 -151773699 NM_014624 1q21 Hs.275243 47

ruffle

calcium ion binding

nucleus

nuclear envelope

cytoplasm

cytoplasm

cell cycle

signal transduction

axonogenesis

growth factor activity

zinc ion binding

cell proliferation

protein homodimerization activity

positive regulation of fibroblast proliferation

S100 beta binding

calcium-dependent protein binding

 
202598_at 1.064 8.934 3.740 1.930e-03 0.273 -1.157 S100A13 S100 calcium binding protein A13 1 -151857899, -151857899, -151857899, -151857899, -151857899 NM_005979 1q21 Hs.516505 24

calcium ion binding

cellular_component

cell differentiation

 
200931_s_at 0.573 10.478 3.086 7.433e-03 0.376 -2.304 VCL vinculin 10 75427877 NM_014000 10q22.2 Hs.643896 78

actin binding

structural molecule activity

cytoplasm

plasma membrane

cell-cell junction

adherens junction

focal adhesion

cell motion

cell adhesion

actin cytoskeleton

oxidoreductase activity

lamellipodium assembly

cell-substrate junction

negative regulation of cell migration

costamere

protein complex

apical junction assembly

alpha-catenin binding

Focal adhesion

Adherens junction

Leukocyte transendothelial migration

Regulation of actin cytoskeleton

1556341_s_at 0.622 6.856 2.843 1.220e-02 0.426 -2.725 MAPK12 mitogen-activated protein kinase 12 22 -49033457 AK098058 22q13.33 Hs.432642 36

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

MAP kinase activity

protein binding

ATP binding

cytoplasm

mitochondrion

DNA damage induced protein phosphorylation

cell cycle

cell cycle arrest

intracellular signaling cascade

Ras protein signal transduction

muscle organ development

transferase activity

myoblast differentiation

MAPK signaling pathway

VEGF signaling pathway

Toll-like receptor signaling pathway

RIG-I-like receptor signaling pathway

T cell receptor signaling pathway

Fc epsilon RI signaling pathway

Leukocyte transendothelial migration

Neurotrophin signaling pathway

GnRH signaling pathway

Amyotrophic lateral sclerosis (ALS)

Epithelial cell signaling in Helicobacter pylori infection

212558_at SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 4 124537405, 124540132 BF508662 4q28.1 Hs.436944 15

ureteric bud development

induction of an organ

protein binding

cytoplasm

cytosol

plasma membrane

multicellular organismal development

regulation of signal transduction

lamellipodium

negative regulation of MAP kinase activity

Jak-STAT signaling pathway

204363_at F3 coagulation factor III (thromboplastin, tissue factor) 1 -94767319 NM_001993 1p22-p21 Hs.62192 257

positive regulation of endothelial cell proliferation

protease binding

activation of plasma proteins involved in acute inflammatory response

activation of blood coagulation via clotting cascade

phospholipid binding

extracellular space

plasma membrane

plasma membrane

anti-apoptosis

activation of caspase activity

blood coagulation, extrinsic pathway

positive regulation of platelet-derived growth factor receptor signaling pathway

integral to membrane

positive regulation of cell migration

extracellular matrix

intrinsic to external side of plasma membrane

cell surface binding

positive regulation of angiogenesis

positive regulation of positive chemotaxis

positive regulation of protein kinase B signaling cascade

Complement and coagulation cascades

232052_at 0.468 6.015 5.408 6.919e-05 0.162 1.609 LOC440944 hypothetical LOC440944 3 -9405536 AL110136 3p25.3 Hs.598958 Hs.652556 2    
203360_s_at 0.562 6.026 2.801 1.330e-02 0.435 -2.798 MYCBP c-myc binding protein 1 -39101222 D50692 1p33-p32.2 Hs.591506 12

transcription coactivator activity

protein binding

nucleus

cytoplasm

mitochondrion

spermatogenesis

regulation of transcription

 
1553600_at TMIE transmembrane inner ear 3 46717826 NM_147196 3p21 Hs.185777 10

sensory perception of sound

membrane

integral to membrane

inner ear morphogenesis

 
212146_at PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 1 15883413 AB020649 1p36.21 Hs.646775 3

cytoplasm

 
212899_at CDC2L6 cell division cycle 2-like 6 (CDK8-like) 6 -111037873 AB028951 6q21 Hs.719138 10

nucleotide binding

cyclin-dependent protein kinase activity

protein binding

ATP binding

protein amino acid phosphorylation

transferase activity

 
206383_s_at 0.561 5.206 3.197 5.908e-03 0.357 -2.109 G3BP2 GTPase activating protein (SH3 domain) binding protein 2 4 -76786976, -76786976 NM_012297 4q21.1 Hs.303676 15

nucleotide binding

RNA binding

protein binding

intracellular

cytoplasm

transport

cytoplasmic sequestering of NF-kappaB

Ras protein signal transduction

receptor signaling complex scaffold activity

mRNA transport

 
214985_at 0.339 3.113 3.040 8.158e-03 0.387 -2.383 EXT1 exostoses (multiple) 1 8 -118880782 AF070571 8q24.11-q24.13 Hs.492618 53

Golgi membrane

skeletal system development

ossification

protein binding

endoplasmic reticulum

Golgi apparatus

glycosaminoglycan biosynthetic process

signal transduction

gastrulation

endoderm development

mesoderm development

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

membrane

integral to membrane

integral to endoplasmic reticulum membrane

heparan sulfate N-acetylglucosaminyltransferase activity

protein homodimerization activity

protein heterodimerization activity

glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

Heparan sulfate biosynthesis

Metabolic pathways

213271_s_at DOPEY1 dopey family member 1 6 83834103 AB029040 6q15 Hs.520246 Hs.708998 6

protein transport

 
212188_at 0.990 7.397 3.822 1.629e-03 0.260 -1.013 KCTD12 potassium channel tetramerisation domain containing 12 13 -76352304 AA551075 13q22.3 Hs.644125 14

voltage-gated potassium channel activity

protein binding

potassium ion transport

voltage-gated potassium channel complex

membrane

 
1555575_a_at 0.241 9.171 2.876 1.142e-02 0.426 -2.669 KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 19 -53577638 BC008958 19q13.3 Hs.515515 14

receptor activity

KDEL sequence binding

protein binding

membrane fraction

endoplasmic reticulum

ER-Golgi intermediate compartment

protein retention in ER lumen

intracellular protein transport

membrane

integral to membrane

vesicle-mediated transport

Vibrio cholerae infection

1563471_at KIAA1632 KIAA1632 18 -41681571 AL833448 18q12.3-q21.1 Hs.514843 8    
225243_s_at 0.478 8.469 2.285 3.706e-02 0.562 -3.657 SLMAP sarcolemma associated protein 3 57718213 AB046821 3p21.2-p14.3 Hs.476432 11

smooth endoplasmic reticulum

plasma membrane

integral to plasma membrane

protein folding

muscle contraction

prefoldin complex

unfolded protein binding

 
242750_at MMAA methylmalonic aciduria (cobalamin deficiency) cblA type 4 146759989 AA678047 4q31.21 Hs.452864 10

nucleotide binding

ATP binding

mitochondrion

nucleoside-triphosphatase activity

 
233169_at ZNF350 zinc finger protein 350 19 -57159404 AU145915 19q13.41 Hs.407694 23

DNA binding

protein binding

intracellular

nucleus

nucleolus

cytoplasm

regulation of transcription, DNA-dependent

zinc ion binding

nuclear matrix

negative regulation of transcription

transcription repressor activity

transcriptional repressor complex

metal ion binding

 
222653_at 0.374 6.777 3.098 7.245e-03 0.375 -2.282 PNPO pyridoxamine 5'-phosphate oxidase 17 43373887 AA005137 17q21.32 Hs.631742 13

pyridoxamine-phosphate oxidase activity

pyridoxine biosynthetic process

FMN binding

oxidoreductase activity, acting on the CH-NH2 group of donors

oxidation reduction

Vitamin B6 metabolism

Metabolic pathways

227886_at CTSD cathepsin D 11 -1730560 AU147615 11p15.5 Hs.121575 Hs.654447 140

autophagic vacuole formation

aspartic-type endopeptidase activity

extracellular region

mitochondrion

lysosome

proteolysis

peptidase activity

melanosome

Lysosome

1553961_s_at 0.719 6.769 4.013 1.100e-03 0.227 -0.681 SNX21 sorting nexin family member 21 20 43895876 CA447177 20q13.12 Hs.472854 8

protein binding

cell communication

protein transport

phosphoinositide binding

 
225601_at 0.891 5.667 3.912 1.354e-03 0.245 -0.856 HMGB3 high-mobility group box 3 X 149902420 AI806853 Xq28 Hs.19114 11

nucleus

chromosome

multicellular organismal development

DNA bending activity

negative regulation of B cell differentiation

negative regulation of myeloid cell differentiation

 
228962_at PDE4D phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) 5 -58300622, -58300622 BF507941 5q12 Hs.117545 89

3',5'-cyclic-AMP phosphodiesterase activity

soluble fraction

insoluble fraction

cytoplasm

centrosome

cytoskeleton

signal transduction

membrane

hydrolase activity

metal ion binding

Purine metabolism

210749_x_at 0.742 7.205 3.400 3.890e-03 0.319 -1.753 DDR1 discoidin domain receptor tyrosine kinase 1 6 30959839, 30960305, 30964443, 2300465, 2300931, 2305069, 2098794, 2099260, 2103398 L11315 6p21.3 Hs.631988 60

nucleotide binding

transmembrane receptor protein tyrosine kinase activity

receptor activity

protein binding

ATP binding

extracellular region

integral to plasma membrane

protein amino acid phosphorylation

cell adhesion

transmembrane receptor protein tyrosine kinase signaling pathway

membrane

transferase activity

 
1554549_a_at 0.570 3.234 2.828 1.257e-02 0.429 -2.750 WDR20 WD repeat domain 20 14 101675964, 101675964, 101675964 BC030654 14q32.31 Hs.36859 7    
221606_s_at NSBP1 nucleosomal binding protein 1 X -80255855 BC005342 Xq13.3 Hs.282204 7

chromatin

DNA binding

chromatin binding

nucleus

nucleoplasm

nucleolus

regulation of transcription from RNA polymerase I promoter

transcription activator activity

 
210753_s_at -0.332 4.633 -2.136 4.931e-02 0.590 -3.892 EPHB1 EPH receptor B1 3 135996949 AF037334 3q21-q23 Hs.116092 41

nucleotide binding

receptor activity

ephrin receptor activity

protein binding

ATP binding

plasma membrane

integral to plasma membrane

protein amino acid phosphorylation

signal transduction

transmembrane receptor protein tyrosine kinase signaling pathway

nervous system development

transferase activity

Axon guidance

1564254_at -0.197 5.437 -2.371 3.135e-02 0.543 -3.518 KY kyphoscoliosis peptidase 3 -135801454 AK090526 3q22.2 Hs.146730 4

cytoplasm

cytoskeleton

peptidase activity

 
213868_s_at DHRS7 dehydrogenase/reductase (SDR family) member 7 14 -59681251 AW243128 14q23.1 Hs.59719 7

binding

oxidoreductase activity

oxidation reduction

 
203567_s_at 0.613 6.397 3.238 5.432e-03 0.352 -2.037 TRIM38 tripartite motif-containing 38 6 26071049 AU157590 6p21.3 Hs.584851 7

signal transducer activity

protein binding

cellular_component

intracellular

zinc ion binding

positive regulation of I-kappaB kinase/NF-kappaB cascade

metal ion binding

 
226180_at 0.646 6.777 3.001 8.840e-03 0.394 -2.451 WDR36 WD repeat domain 36 5 110455768 BF439595 5q22.1 Hs.533237 19

molecular_function

cellular_component

rRNA processing

visual perception

small-subunit processome

response to stimulus

 
222396_at 0.700 8.041 2.146 4.841e-02 0.589 -3.877 HN1 hematological and neurological expressed 1 17 -70642938, -70642938 AF060925 17q25.1 Hs.532803 Hs.713826 9

nucleus

 
226996_at LCLAT1 lysocardiolipin acyltransferase 1 2 30523626, 30523640 AV717041 2p23.1 Hs.468048 Hs.662770 8

1-acylglycerol-3-phosphate O-acyltransferase activity

endoplasmic reticulum

multicellular organismal development

metabolic process

acyltransferase activity

phospholipid biosynthetic process

membrane

integral to membrane

transferase activity

Tyrosine metabolism

Phenylalanine metabolism

Glycerolipid metabolism

Glycerophospholipid metabolism

Ether lipid metabolism

1- and 2-Methylnaphthalene degradation

Benzoate degradation via CoA ligation

Limonene and pinene degradation

Metabolic pathways

209155_s_at NT5C2 5'-nucleotidase, cytosolic II 10 -104835929 BC001595 10q24.32-q24.33 Hs.97439 12

nucleotide binding

magnesium ion binding

protein binding

cytoplasm

cytosol

5'-nucleotidase activity

5'-nucleotidase activity

nucleotide metabolic process

hydrolase activity

Purine metabolism

Pyrimidine metabolism

Nicotinate and nicotinamide metabolism

Biosynthesis of alkaloids derived from histidine and purine

Metabolic pathways

235440_at 0.356 4.024 3.073 7.634e-03 0.378 -2.327 SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 11 -18584523 BE780878 11p15.1 Hs.268668 Hs.719399 2    
202642_s_at 0.417 5.955 2.572 2.106e-02 0.497 -3.186 TRRAP transformation/transcription domain-associated protein 7 98314048 NM_003496 7q21.2-q22.1 Hs.203952 Hs.706926 40

PCAF complex

transcription cofactor activity

protein binding

nucleus

chromatin modification

histone deubiquitination

phosphotransferase activity, alcohol group as acceptor

STAGA complex

transcription factor TFTC complex

NuA4 histone acetyltransferase complex

histone H4 acetylation

histone H2A acetylation

regulation of transcription

 
211071_s_at 1.069 8.059 3.091 7.347e-03 0.376 -2.294 MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 1 149298774 BC006471 1q21 Hs.75823 9

molecular_function

cellular_component

 
225814_at XRN1 5'-3' exoribonuclease 1 3 -143508138 BG534738 3q23 Hs.435103 12

DNA binding

RNA binding

protein binding

intracellular

cytoplasm

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

5'-3' exonuclease activity

hydrolase activity

RNA degradation

202204_s_at AMFR autocrine motility factor receptor 16 -54952864 AF124145 16q21 Hs.295137 33

protein polyubiquitination

integral to membrane of membrane fraction

ubiquitin-protein ligase activity

ubiquitin-protein ligase activity

receptor activity

receptor activity

protein binding

endoplasmic reticulum

ubiquitin-dependent protein catabolic process

cell motion

signal transduction

zinc ion binding

membrane

integral to membrane

integral to membrane

ligase activity

integral to endoplasmic reticulum membrane

ER-associated protein catabolic process

ER-associated protein catabolic process

endoplasmic reticulum unfolded protein response

metal ion binding

protein oligomerization

 
225978_at 0.593 5.474 2.369 3.149e-02 0.543 -3.522 RIMKLB ribosomal modification protein rimK-like family member B 12 8741784 AW409794 12p13.31 Hs.504670 4

nucleotide binding

catalytic activity

ATP binding

protein modification process

manganese ion binding

metal ion binding

 
221649_s_at 0.346 6.484 3.988 1.159e-03 0.231 -0.725 PPAN peter pan homolog (Drosophila) 19 10077964 BC000535 19p13 Hs.14468 15

protein binding

nucleus

nucleolus

RNA splicing

 
205499_at 0.680 4.423 5.119 1.206e-04 0.162 1.159 SRPX2 sushi-repeat-containing protein, X-linked 2 X 99785818 NM_014467 Xq21.33-q23 Hs.306339 13

extracellular region

 
1557349_at RERE arginine-glutamic acid dipeptide (RE) repeats 1 -8335050, -8335050 AK096094 1p36.2-p36.1 Hs.463041 17

histone deacetylase complex

transcription factor activity

nucleus

chromatin remodeling

regulation of transcription, DNA-dependent

NLS-bearing substrate import into nucleus

multicellular organismal development

poly-glutamine tract binding

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
215942_s_at GTSE1 G-2 and S-phase expressed 1 22 45071301 BF973178 22q13.2-q13.3 Hs.386189 18

G2 phase of mitotic cell cycle

molecular_function

cytoplasm

cytoplasmic microtubule

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

microtubule-based process

p53 signaling pathway

215559_at ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 16 -16222544, -16150922 AI074459 16p13.1 Hs.442182 70

nucleotide binding

transporter activity

ATP binding

plasma membrane

transport

visual perception

integral to membrane

ATPase activity

response to drug

ATPase activity, coupled to transmembrane movement of substances

response to stimulus

ABC transporters

225160_x_at MDM2 Mdm2 p53 binding protein homolog (mouse) 12 67488237, 67489063 AI952357 12q14.3-q15 Hs.484551 555

negative regulation of transcription from RNA polymerase II promoter

negative regulation of transcription from RNA polymerase II promoter

p53 binding

ubiquitin-protein ligase activity

intracellular

insoluble fraction

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

cytosol

protein complex assembly

zinc ion binding

positive regulation of cell proliferation

ligase activity

basal transcription repressor activity

basal transcription repressor activity

enzyme binding

modification-dependent protein catabolic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process

protein ubiquitination during ubiquitin-dependent protein catabolic process

identical protein binding

interspecies interaction between organisms

metal ion binding

Cell cycle

p53 signaling pathway

Ubiquitin mediated proteolysis

Endocytosis

Pathways in cancer

Glioma

Prostate cancer

Melanoma

Bladder cancer

Chronic myeloid leukemia

202055_at KPNA1 karyopherin alpha 1 (importin alpha 5) 3 -123623437 AA652173 3q21 Hs.161008 92

regulation of DNA recombination

protein binding

nucleus

nuclear pore

nucleoplasm

cytoplasm

cytosol

NLS-bearing substrate import into nucleus

intracellular protein transport

nuclear localization sequence binding

protein transporter activity

interspecies interaction between organisms

 
217830_s_at NSFL1C NSFL1 (p97) cofactor (p47) 20 -1370810 AL109658 20p13 Hs.12865 20

protein binding

nucleus

Golgi apparatus

Golgi stack

lipid binding

 
223547_at JKAMP JNK1/MAPK8-associated membrane protein 14 59020913 AL038769 14q23.1 Hs.446850 12

plasma membrane

integral to membrane

 
225164_s_at 0.325 5.534 2.844 1.217e-02 0.426 -2.723 EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 15 38013638 AB037759 15q15.1 Hs.656673 10

nucleotide binding

eukaryotic translation initiation factor 2alpha kinase activity

aminoacyl-tRNA ligase activity

protein binding

ATP binding

intracellular

cytoplasm

tRNA aminoacylation for protein translation

regulation of translational initiation

protein amino acid phosphorylation

transferase activity

cytosolic ribosome

 
210211_s_at 0.355 11.097 2.519 2.344e-02 0.507 -3.275 HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 14 -101616827, -101616827 AF028832 14q32.33 Hs.525600 Hs.700831 275

nucleotide binding

ATP binding

cytoplasm

cytosol

cytosol

mitochondrial transport

response to unfolded protein

signal transduction

nitric-oxide synthase regulator activity

TPR domain binding

TPR domain binding

cellular chaperone-mediated protein complex assembly

protein refolding

melanosome

protein homodimerization activity

positive regulation of nitric oxide biosynthetic process

unfolded protein binding

mitochondrial outer membrane translocase complex assembly

Antigen processing and presentation

Pathways in cancer

Prostate cancer

244462_at 0.440 3.408 3.041 8.149e-03 0.387 -2.382 ZNF224 zinc finger protein 224 19 49290336 AA811983 19q13.2 Hs.585869 10

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
213571_s_at EIF4E2 eukaryotic translation initiation factor 4E family member 2 2 233123600 BF516289 2q37.1 Hs.292026 Hs.700929 15

RNA cap binding

translation initiation factor activity

protein binding

cytoplasm

translational initiation

regulation of translation

mTOR signaling pathway

Insulin signaling pathway

230285_at SVIP small VCP/p97-interacting protein 11 -22800173 BF447829 11p14.2 Hs.349096 4

endoplasmic reticulum

Golgi apparatus

plasma membrane

 
1559315_s_at -0.233 2.890 -2.494 2.462e-02 0.513 -3.317 LOC144481 hypothetical protein LOC144481 12   AK054607 12q22 Hs.602278 1    
232643_at -0.251 5.610 -2.488 2.491e-02 0.513 -3.326 POLR2F polymerase (RNA) II (DNA directed) polypeptide F 22 36679619 AK026327 22q13.1 Hs.436578 87

nuclear mRNA splicing, via spliceosome

DNA binding

DNA-directed RNA polymerase activity

nucleus

nucleoplasm

nucleolus

transcription initiation from RNA polymerase II promoter

RNA elongation from RNA polymerase II promoter

RNA polymerase complex

Purine metabolism

Pyrimidine metabolism

Metabolic pathways

RNA polymerase

Huntington's disease

1559061_at LOC253962 hypothetical protein LOC253962 17   BC041476 17q21.33 Hs.558704 1    
201122_x_at 0.738 9.062 3.703 2.080e-03 0.275 -1.221 EIF5A eukaryotic translation initiation factor 5A 17 7151041, 7151579, 7152011, 7152417 BC000751 17p13-p12 Hs.534314 52

RNA binding

translation initiation factor activity

translation elongation factor activity

nucleus

annulate lamellae

nuclear pore

cytoplasm

endoplasmic reticulum

cytosol

mRNA export from nucleus

translation

translational frameshifting

protein export from nucleus

nucleocytoplasmic transport

nucleocytoplasmic transport

induction of apoptosis

cell proliferation

peptidyl-lysine modification to hypusine

peptidyl-lysine modification to hypusine

protein transport

membrane

U6 snRNA binding

viral genome replication

ribosome binding

positive regulation of translational elongation

positive regulation of translational termination

positive regulation of translational initiation

protein N-terminus binding

intracellular protein transmembrane transport

 
200945_s_at SEC31A SEC31 homolog A (S. cerevisiae) 4 -83958837 NM_014933 4q21.22 Hs.370024 20

cytoplasm

endoplasmic reticulum

ER to Golgi vesicle-mediated transport

ER to Golgi vesicle-mediated transport

protein transport

membrane

membrane organization

vesicle-mediated transport

COPII vesicle coat

cytoplasmic vesicle

calcium-dependent protein binding

perinuclear region of cytoplasm

response to calcium ion

 
220552_at -0.317 2.509 -3.726 1.985e-03 0.273 -1.181 TRPC5 transient receptor potential cation channel, subfamily C, member 5 X -110904197 NM_012471 Xq23 Hs.657709 27

ion channel activity

calcium ion binding

protein binding

integral to plasma membrane

ion transport

calcium ion transport

nervous system development

store-operated calcium channel activity

membrane

 
205591_at OLFM1 olfactomedin 1 9 137106909, 137106923 NM_006334 9q34.3 Hs.522484 9

protein binding

endoplasmic reticulum

endoplasmic reticulum lumen

multicellular organismal development

nervous system development

membrane

 
223355_at 0.320 4.114 3.546 2.878e-03 0.297 -1.497 ALG1 asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae) 16 5061810 BC004402 16p13.3 Hs.592086 9

chitobiosyldiphosphodolichol beta-mannosyltransferase activity

endoplasmic reticulum

protein amino acid glycosylation

biosynthetic process

lipopolysaccharide biosynthetic process

membrane

integral to membrane

transferase activity, transferring glycosyl groups

N-Glycan biosynthesis

Metabolic pathways

226648_at 0.448 6.811 2.981 9.221e-03 0.400 -2.487 HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 10 102285630 AI769745 10q24 Hs.500788 30

peptide-aspartate beta-dioxygenase activity

iron ion binding

protein binding

nucleus

oxidoreductase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

regulation of transcription

metal ion binding

oxidation reduction

 
201765_s_at 0.354 7.537 3.913 1.350e-03 0.245 -0.854 HEXA hexosaminidase A (alpha polypeptide) 15 -70422831 AL523158 15q23-q24 Hs.604479 Hs.709495 93

skeletal system development

hydrolase activity, hydrolyzing O-glycosyl compounds

beta-N-acetylhexosaminidase activity

protein binding

lysosome

carbohydrate metabolic process

ganglioside catabolic process

lysosome organization

sensory perception of sound

locomotory behavior

adult walking behavior

metabolic process

membrane

lipid storage

sexual reproduction

glycosaminoglycan metabolic process

myelination

cation binding

protein heterodimerization activity

neuromuscular process controlling posture

neuromuscular process controlling balance

Other glycan degradation

Amino sugar and nucleotide sugar metabolism

Glycosaminoglycan degradation

Glycosphingolipid biosynthesis - globo series

Glycosphingolipid biosynthesis - ganglio series

Metabolic pathways

Lysosome

1556667_at 0.789 5.469 2.229 4.128e-02 0.571 -3.746 LOC348751 hypothetical protein LOC348751 2   BC039445 2q33.1 Hs.471039 1    
209824_s_at ARNTL aryl hydrocarbon receptor nuclear translocator-like 11 13255900 AB000812 11p15 Hs.65734 37

transcription factor activity

signal transducer activity

nucleus

transcription factor complex

regulation of transcription, DNA-dependent

signal transduction

circadian rhythm

aryl hydrocarbon receptor binding

positive regulation of transcription from RNA polymerase II promoter

Hsp90 protein binding

Circadian rhythm - mammal

216199_s_at MAP3K4 mitogen-activated protein kinase kinase kinase 4 6 161332811 AL109942 6q26 Hs.390428 20

nucleotide binding

activation of MAPKK activity

magnesium ion binding

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

ATP binding

response to stress

JNK cascade

transferase activity

MAPK signaling pathway

GnRH signaling pathway

218024_at -0.374 10.668 -2.178 4.551e-02 0.581 -3.827 BRP44L brain protein 44-like 6 -166698399 NM_016098 6q27 Hs.172755 7

molecular_function

cellular_component

mitochondrion

biological_process

 
1553715_s_at C16orf14 chromosome 16 open reading frame 14 16 631849 NM_032371 16p13.3 Hs.417710 5

protein binding

 
231132_at -0.354 5.284 -3.508 3.112e-03 0.303 -1.563 LOC348120 hypothetical protein LOC348120 15   AW002496 15q11.2 Hs.116287 1    
217841_s_at PPME1 protein phosphatase methylesterase 1 11 73560015 NM_016147 11q13.4 Hs.503251 10

carboxylesterase activity

phosphoprotein phosphatase inhibitor activity

protein amino acid demethylation

protein phosphatase type 2A regulator activity

hydrolase activity

protein phosphatase 2A binding

protein C-terminal methylesterase activity

Tropane, piperidine and pyridine alkaloid biosynthesis

225433_at GTF2A1 general transcription factor IIA, 1, 19/37kDa 14 -80716146, -80716146 AU144104 14q31.1 Hs.592334 Hs.593630 45

DNA binding

transcription coactivator activity

nucleus

nucleoplasm

transcription factor TFIIA complex

nucleolus

cytoplasm

transcription initiation from RNA polymerase II promoter

transcription initiation from RNA polymerase II promoter

RNA elongation from RNA polymerase II promoter

transcription factor binding

general RNA polymerase II transcription factor activity

TATA-binding protein binding

general transcription from RNA polymerase II promoter

regulation of transcription

protein heterodimerization activity

Basal transcription factors

213245_at -0.569 5.967 -2.919 1.047e-02 0.418 -2.595 ADCY1 adenylate cyclase 1 (brain) 7 45580649 AL120173 7p13-p12 Hs.192215 24

nucleotide binding

magnesium ion binding

calmodulin binding

ATP binding

cAMP biosynthetic process

long-term memory

calcium- and calmodulin-responsive adenylate cyclase activity

hormone-mediated signaling

membrane

integral to membrane

Purine metabolism

Calcium signaling pathway

Chemokine signaling pathway

Vascular smooth muscle contraction

Gap junction

Long-term potentiation

GnRH signaling pathway

Melanogenesis

218152_at HMG20A high-mobility group 20A 15 75500297 NM_018200 15q24 Hs.69594 9

transcription factor activity

protein binding

nucleus

nucleolus

regulation of transcription, DNA-dependent

chromatin modification

 
222156_x_at 0.392 6.792 2.246 3.995e-02 0.568 -3.719 CCPG1 cell cycle progression 1 15 -53434729, -53434729 AK022459 15q21.1 Hs.285051 5

cell cycle

membrane

integral to membrane

 
201935_s_at EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 1 -21005560 AI768122 1p36.12 Hs.467084 19

RNA cap binding

translation initiation factor activity

protein binding

regulation of translational initiation

RNA metabolic process

eukaryotic translation initiation factor 4F complex

interspecies interaction between organisms

 
1553956_at ALS2CR4 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4 2 -202193151, -202193151 BG194770   Hs.12319 5

membrane

integral to membrane

 
1552418_at TTLL10 tubulin tyrosine ligase-like family, member 10 1 1099148, 1104939 NM_153254 1p36.33 Hs.454835 4

tubulin-tyrosine ligase activity

cytoplasm

cytoskeleton

microtubule

protein modification process

ligase activity

protein polyglycylation

protein-glycine ligase activity

 
219981_x_at ZNF587 zinc finger protein 587 19 63053080 NM_017961 19q13.43 Hs.642598 Hs.715493 6

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
243738_at NMNAT3 nicotinamide nucleotide adenylyltransferase 3 3 -140761722 AW172570 3q23 Hs.208673 6

nucleotide binding

magnesium ion binding

nicotinamide-nucleotide adenylyltransferase activity

nicotinate-nucleotide adenylyltransferase activity

ATP binding

mitochondrion

biosynthetic process

NAD biosynthetic process

transferase activity

nucleotidyltransferase activity

pyridine nucleotide biosynthetic process

Nicotinate and nicotinamide metabolism

Metabolic pathways

212271_at 0.354 7.929 2.683 1.688e-02 0.467 -2.999 MAPK1 mitogen-activated protein kinase 1 22 -20453318, -20443946 AA195999 22q11.2 22q11.21 Hs.431850 822

MAPKKK cascade

nucleotide binding

phosphotyrosine binding

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

cytosol

cytoskeleton

protein amino acid phosphorylation

induction of apoptosis

chemotaxis

response to DNA damage stimulus

cell cycle

Ras protein signal transduction

synaptic transmission

organ morphogenesis

transferase activity

MAP kinase 2 activity

cytosine metabolic process

lipopolysaccharide-mediated signaling pathway

response to lipopolysaccharide

response to exogenous dsRNA

interspecies interaction between organisms

negative regulation of cell differentiation

T cell receptor signaling pathway

B cell receptor signaling pathway

MAPK signaling pathway

ErbB signaling pathway

Chemokine signaling pathway

mTOR signaling pathway

Vascular smooth muscle contraction

Dorso-ventral axis formation

TGF-beta signaling pathway

Axon guidance

VEGF signaling pathway

Focal adhesion

Adherens junction

Gap junction

Toll-like receptor signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Fc gamma R-mediated phagocytosis

Long-term potentiation

Neurotrophin signaling pathway

Long-term depression

Regulation of actin cytoskeleton

Insulin signaling pathway

GnRH signaling pathway

Melanogenesis

Type II diabetes mellitus

Alzheimer's disease

Prion diseases

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Endometrial cancer

Glioma

Prostate cancer

Thyroid cancer

Melanoma

Bladder cancer

Chronic myeloid leukemia

Acute myeloid leukemia

Non-small cell lung cancer

219440_at RAI2 retinoic acid induced 2 X -17728089 NM_021785 Xp22 Hs.446680 8

molecular_function

cellular_component

embryonic development

 
213581_at 0.857 5.606 4.051 1.019e-03 0.225 -0.616 PDCD2 programmed cell death 2 6 -170732759, -170728374 BF446180 6q27 Hs.367900 14

DNA binding

protein binding

nucleus

cytoplasm

apoptosis

zinc ion binding

metal ion binding

 
202778_s_at ZMYM2 zinc finger, MYM-type 2 13 19430809 NM_003453 13q11-q12 Hs.644041 29

protein binding

cellular_component

nucleus

biological_process

zinc ion binding

PML body

ubiquitin conjugating enzyme binding

regulation of transcription

metal ion binding

 
212248_at MTDH metadherin 8 98725582 AI886796 8q22.1 Hs.377155 23

negative regulation of transcription from RNA polymerase II promoter

protein binding

nucleus

nucleolus

cytoplasm

endoplasmic reticulum

tight junction

membrane

integral to membrane

cell junction

nuclear membrane

perinuclear region of cytoplasm

NF-kappaB binding

positive regulation of NF-kappaB transcription factor activity

 
218527_at 0.202 6.301 2.197 4.390e-02 0.579 -3.797 APTX aprataxin 9 -32962607, -32962607, -32962607, -32962607, -32962607 NM_017692 9p13.3 Hs.20158 41

single strand break repair

chromatin

chromatin binding

damaged DNA binding

double-stranded DNA binding

double-stranded RNA binding

intracellular

nucleus

nucleoplasm

nucleolus

response to DNA damage stimulus

cell death

zinc ion binding

phosphoglycolate phosphatase activity

hydrolase activity

regulation of protein stability

DNA 5'-adenosine monophosphate hydrolase activity

response to hydrogen peroxide

metal ion binding

protein N-terminus binding

 
209448_at 0.529 6.969 2.723 1.557e-02 0.459 -2.931 HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 11 20341806, 20341822, 20341864, 20341978, 20342262 BC002439 11p15.1 Hs.90753 31

RNA polymerase II transcription factor activity

transcription coactivator activity

protein binding

nucleus

nuclear envelope

cytoplasm

regulation of transcription from RNA polymerase II promoter

anti-apoptosis

induction of apoptosis

multicellular organismal development

oxidoreductase activity

cell differentiation

regulation of apoptosis

interspecies interaction between organisms

regulation of angiogenesis

nuclear import

oxidation reduction

 
221903_s_at 0.952 6.645 3.030 8.337e-03 0.387 -2.402 CYLD cylindromatosis (turban tumor syndrome) 16 49333461, 49333529 BE046443 16q12.1 Hs.578973 54

structural constituent of ribosome

ubiquitin thiolesterase activity

intracellular

cytoplasm

ribosome

cytoskeleton

translation

ubiquitin-dependent protein catabolic process

cell cycle

peptidase activity

cysteine-type peptidase activity

perinuclear region of cytoplasm

RIG-I-like receptor signaling pathway

226822_at 0.444 5.658 2.857 1.186e-02 0.426 -2.701 STOX2 storkhead box 2 4 185063502 AL512713 4q35.1 Hs.21958 Hs.696657 3    
200918_s_at SRPR signal recognition particle receptor (docking protein) 11 -125638043 NM_003139 11q24.3 Hs.368376 7

nucleotide binding

GTPase activity

receptor activity

signal recognition particle binding

protein binding

GTP binding

endoplasmic reticulum

signal recognition particle receptor complex

SRP-dependent cotranslational protein targeting to membrane

intracellular protein transport

membrane

integral to membrane

Protein export

227334_at 0.631 9.327 2.252 3.953e-02 0.568 -3.710 USP54 ubiquitin specific peptidase 54 10 -74927301 AW242125 10q22.2 Hs.657355 6

ubiquitin thiolesterase activity

protein binding

ubiquitin-dependent protein catabolic process

 
222800_at -0.244 5.112 -3.020 8.514e-03 0.389 -2.419 TRNAU1AP tRNA selenocysteine 1 associated protein 1 1 28752115 BC000680 1p35.3 Hs.533626 5

nucleotide binding

selenocysteine incorporation

RNA binding

nucleus

cytoplasm

translation

 
228871_at -0.275 4.140 -3.384 4.017e-03 0.323 -1.780 ALG14 asparagine-linked glycosylation 14 homolog (S. cerevisiae) 1 -95220866 AI652839 1p21.3 Hs.408927 5

endoplasmic reticulum

membrane

integral to membrane

N-Glycan biosynthesis

Metabolic pathways

226723_at CCDC23 coiled-coil domain containing 23 1 -43045309 AI581511 1p34.2 Hs.113919 4    
1554600_s_at 0.477 7.290 3.564 2.775e-03 0.292 -1.466 LMNA lamin A/C 1 154351084, 154351084 BC033088 1q21.2-q21.3 Hs.594444 279

structural molecule activity

protein binding

nucleus

cytoplasm

intermediate filament

plasma membrane

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

223316_at 0.677 7.140 3.144 6.588e-03 0.366 -2.201 CCDC3 coiled-coil domain containing 3 10 -12978630 AL136562 10p13 Hs.498720 8

endoplasmic reticulum

 
223206_s_at 0.613 4.955 3.742 1.919e-03 0.273 -1.152 NMRAL1 NmrA-like family domain containing 1 16 -4451695 BC002927 16p13.3 Hs.288969 8

binding

regulation of nitrogen utilization

oxidoreductase activity

transcription repressor activity

oxidation reduction

 
207233_s_at MITF microphthalmia-associated transcription factor 3 69871322, 69895651, 69998131, 70010945, 70068442 NM_000248 3p14.2-p14.1 Hs.166017 Hs.618266 93

DNA binding

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

transcription activator activity

transcription activator activity

melanocyte differentiation

Melanogenesis

Pathways in cancer

Melanoma

1554352_s_at 0.257 5.320 2.283 3.720e-02 0.562 -3.660 DENND4A DENN/MADD domain containing 4A 15 -63740012 BC041706 15q22.31 Hs.654567 8

DNA binding

protein binding

nucleus

regulation of transcription, DNA-dependent

 
224843_at 0.291 4.779 2.299 3.607e-02 0.558 -3.635 SLAIN2 SLAIN motif family, member 2 4 48038369 AB040891 4p11 Hs.479677 5    
1553146_at -0.301 4.228 -2.796 1.344e-02 0.437 -2.806 C3orf30 chromosome 3 open reading frame 30 3 120347686 NM_152539 3q13.32 Hs.632574 1    
213988_s_at 0.408 5.980 2.428 2.806e-02 0.529 -3.426 SAT1 spermidine/spermine N1-acetyltransferase 1 X 23711195 BE971383 Xp22.1 Hs.28491 46

diamine N-acetyltransferase activity

protein binding

intracellular

cytoplasm

metabolic process

acyltransferase activity

transferase activity

Arginine and proline metabolism

Metabolic pathways

202780_at 1.282 7.181 2.607 1.964e-02 0.491 -3.127 OXCT1 3-oxoacid CoA transferase 1 5 -41765923 NM_000436 5p13.1 Hs.278277 15

mitochondrion

mitochondrion

mitochondrial matrix

mitochondrial matrix

metabolic process

3-oxoacid CoA-transferase activity

3-oxoacid CoA-transferase activity

transferase activity

protein homodimerization activity

ketone body catabolic process

Synthesis and degradation of ketone bodies

Valine, leucine and isoleucine degradation

Butanoate metabolism

223429_x_at 0.255 6.937 2.336 3.359e-02 0.552 -3.576 ISY1 ISY1 splicing factor homolog (S. cerevisiae) 3 -130330924 BC004122 3q21.3 Hs.512661 7

nucleus

spliceosomal complex

nucleolus

cytoplasm

mRNA processing

RNA splicing

 
225010_at CCDC6 coiled-coil domain containing 6 10 -61218526 AK024913 10q21 Hs.591360 20

structural constituent of cytoskeleton

protein binding

cellular_component

cytoplasm

cytoskeleton

biological_process

SH3 domain binding

Pathways in cancer

Thyroid cancer

235867_at GSTM3 glutathione S-transferase mu 3 (brain) 1 -110078076 AI459140 1p13.3 Hs.2006 96

glutathione transferase activity

cytoplasm

establishment of blood-nerve barrier

metabolic process

transferase activity

identical protein binding

response to estrogen stimulus

Glutathione metabolism

Metabolism of xenobiotics by cytochrome P450

Drug metabolism - cytochrome P450

234698_at -0.322 4.887 -3.235 5.465e-03 0.352 -2.042 N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) 21 -29166383 AK021678 21q21.3 Hs.163846 6

nucleic acid binding

protein binding

protein methyltransferase activity

transferase activity

positive regulation of cell growth

methylation

protein complex

 
203285_s_at 0.516 4.425 2.987 9.109e-03 0.398 -2.477 HS2ST1 heparan sulfate 2-O-sulfotransferase 1 1 87152922, 87152922 NM_012262 1p31.1-p22.1 Hs.719144 9

Golgi apparatus

membrane

integral to membrane

transferase activity

Heparan sulfate biosynthesis

206587_at 0.553 5.253 3.582 2.673e-03 0.290 -1.434 CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 17 -30279050 NM_006584 17q12 Hs.73072 9

nucleotide binding

ATP binding

cytoplasm

protein folding

spermatogenesis

protein transporter activity

unfolded protein binding

chaperone-mediated protein complex assembly

 
201671_x_at USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 18 148482 BC003556 18p11.32 Hs.464416 Hs.707058 15

cysteine-type endopeptidase activity

ubiquitin thiolesterase activity

ubiquitin-specific protease activity

cytoplasm

ubiquitin-dependent protein catabolic process

tRNA guanylyltransferase activity

peptidase activity

 
209741_x_at SCAPER S-phase cyclin A-associated protein in the ER 15 -74427583, -74427583 AF119814 15q24 Hs.458986 7

intracellular

nucleus

endoplasmic reticulum

zinc ion binding

metal ion binding

 
204408_at -0.297 5.554 -2.927 1.029e-02 0.418 -2.581 APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 X 55043504 NM_014481 Xp11.21 Hs.659558 8

DNA binding

DNA-(apurinic or apyrimidinic site) lyase activity

endonuclease activity

intracellular

nucleus

mitochondrion

DNA repair

response to DNA damage stimulus

zinc ion binding

lyase activity

Base excision repair

209018_s_at 0.332 9.533 2.690 1.665e-02 0.465 -2.988 PINK1 PTEN induced putative kinase 1 1 20832534 BF432478 1p36 Hs.389171 105

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

ATP binding

mitochondrion

mitochondrial outer membrane

protein amino acid phosphorylation

response to stress

protein kinase cascade

membrane

integral to membrane

transferase activity

positive regulation of synaptic transmission, dopaminergic

positive regulation of dopamine secretion

Parkinson's disease

202156_s_at CUGBP2 CUG triplet repeat, RNA binding protein 2 10 11087264, 11099898, 11246998 N36839 10p13 Hs.309288 25

nucleotide binding

RNA binding

protein binding

nucleus

cytoplasm

mRNA processing

regulation of heart contraction

 
218876_at 1.299 6.526 3.204 5.832e-03 0.357 -2.098 TPPP3 tubulin polymerization-promoting protein family member 3 16 -65981212 NM_016140 16q22.1 Hs.534458 8    
208485_x_at 0.677 7.301 3.981 1.175e-03 0.231 -0.736 CFLAR CASP8 and FADD-like apoptosis regulator 2 201689060, 201689134, 201691631 NM_003879 2q33-q34 Hs.390736 163

cysteine-type endopeptidase activity

protein binding

proteolysis

anti-apoptosis

induction of apoptosis by extracellular signals

regulation of apoptosis

positive regulation of I-kappaB kinase/NF-kappaB cascade

interspecies interaction between organisms

Apoptosis

208815_x_at 0.397 7.873 2.932 1.019e-02 0.417 -2.572 HSPA4 heat shock 70kDa protein 4 5 132415560 AB023420 5q31.1-q31.2 Hs.90093 108

nucleotide binding

ATP binding

nucleus

cytoplasm

response to unfolded protein

cellular chaperone-mediated protein complex assembly

mitochondrial outer membrane translocase complex assembly

Antigen processing and presentation

236192_at HOOK3 hook homolog 3 (Drosophila) 8 42871189 BF447112 8p11.21 Hs.162852 13

cytoplasm

Golgi apparatus

cis-Golgi network

cytoskeleton

microtubule

endosome organization

lysosome organization

microtubule binding

endosome to lysosome transport

protein transport

HOPS complex

cytoplasmic microtubule organization

identical protein binding

early endosome to late endosome transport

Golgi localization

FHF complex

 
214552_s_at 0.714 5.461 2.711 1.596e-02 0.459 -2.952 RABEP1 rabaptin, RAB GTPase binding effector protein 1 17 5126281 AF098638 17p13.2 Hs.584784 Hs.592121 19

GTPase activator activity

protein binding

cytoplasm

early endosome

endocytosis

apoptosis

membrane fusion

growth factor activity

protein transport

recycling endosome

Endocytosis

204417_at GALC galactosylceramidase 14 -87499410, -87469110 NM_000153 14q31 Hs.513439 27

galactosylceramidase activity

lysosome

carbohydrate metabolic process

galactosylceramide catabolic process

metabolic process

hydrolase activity, acting on glycosyl bonds

cation binding

Sphingolipid metabolism

Metabolic pathways

Lysosome

209840_s_at 1.116 5.365 3.488 3.245e-03 0.306 -1.599 LRRN3 leucine rich repeat neuronal 3 7 110518297 AI221950 7q31.1 Hs.3781 6

protein binding

membrane

integral to membrane

 
227970_at -0.808 8.917 -4.064 9.921e-04 0.223 -0.594 GPR157 G protein-coupled receptor 157 1 -9087062 AK026883 1p36.23 Hs.632367 5

G-protein coupled receptor activity

plasma membrane

G-protein coupled receptor protein signaling pathway

integral to membrane

 
211954_s_at 0.237 9.184 2.338 3.346e-02 0.552 -3.572 IPO5 importin 5 13 97403929 BC000947 13q32.2 Hs.712598 53

protein import into nucleus, docking

GTPase inhibitor activity

protein binding

nucleus

nuclear pore

nucleolus

cytoplasm

NLS-bearing substrate import into nucleus

intracellular protein transport

Ran GTPase binding

protein transporter activity

interspecies interaction between organisms

 
228728_at -0.494 9.498 -3.456 3.463e-03 0.308 -1.654 C7orf58 chromosome 7 open reading frame 58 7 120415986, 120416680 BF724137 7q31.31 Hs.189652 13

endoplasmic reticulum

 
206625_at 0.849 6.668 2.336 3.354e-02 0.552 -3.574 PRPH2 peripherin 2 (retinal degeneration, slow) 6 -42772310 NM_000322 6p21.2-p12.3 Hs.654489 57

protein binding

cell adhesion

visual perception

membrane

integral to membrane

response to stimulus

retina development in camera-type eye

Amyotrophic lateral sclerosis (ALS)

213224_s_at 0.268 6.000 2.161 4.706e-02 0.584 -3.854 NCRNA00081 non-protein coding RNA 81 10 -112648478, -112648478 AK025724 10q25.2 Hs.232543 Hs.651480 4

cytoplasm

cilium

 
235798_at TMEM170B transmembrane protein 170B 6 11646496 BE671123 6p24.2 Hs.146317 1

membrane

integral to membrane

 
35254_at TRAFD1 TRAF-type zinc finger domain containing 1 12 111047731 AB007447 12q Hs.5148 10

protein binding

intracellular

zinc ion binding

metal ion binding

 
231875_at 0.798 4.875 3.636 2.390e-03 0.284 -1.339 KIF21A kinesin family member 21A 12 -37973296 AF155117 12q12 Hs.374201 25

nucleotide binding

microtubule motor activity

ATP binding

microtubule

microtubule-based movement

 
219760_at LIN7B lin-7 homolog B (C. elegans) 19 54309429 NM_022165 19q13.3 Hs.221737 15

protein binding

plasma membrane

tight junction

exocytosis

neurotransmitter secretion

protein transport

synaptosome

cell junction

synapse

postsynaptic membrane

 
242287_at 0.711 6.343 3.245 5.351e-03 0.351 -2.024 CLIP1 CAP-GLY domain containing linker protein 1 12 -121321933 AI090487 12q24.3 Hs.524809 37

kinetochore

nucleic acid binding

protein binding

cytoplasm

endosome

microtubule

intermediate filament

mitosis

microtubule binding

zinc ion binding

protein homodimerization activity

metal ion binding

 
234325_at C2orf65 chromosome 2 open reading frame 65 2 -74638517 Y12839 2p13.1 Hs.348645 3    
242757_at MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 6 -37708261 BE730067 6p21 Hs.437993 6

neuron migration

molecular_function

plasma membrane

multicellular organismal development

nervous system development

brain development

spinal cord association neuron differentiation

cell differentiation

anchored to plasma membrane

 
224164_at 1.150 5.235 2.659 1.770e-02 0.473 -3.039 TPM3 tropomyosin 3 1 -152400913, -152394403 AY004867 1q21.2 Hs.535581 Hs.644306 Hs.654421 66

molecular_function

actin binding

protein binding

cytoplasm

cytoskeleton

cytoskeleton

muscle thin filament tropomyosin

cell motion

regulation of muscle contraction

Cardiac muscle contraction

Pathways in cancer

Thyroid cancer

Hypertrophic cardiomyopathy (HCM)

210829_s_at 0.646 6.766 3.619 2.473e-03 0.287 -1.368 SSBP2 single-stranded DNA binding protein 2 5 -80751427 AF077048 5q14.1 Hs.102735 14

DNA binding

single-stranded DNA binding

protein binding

nucleus

cytoplasm

transcription regulator activity

regulation of transcription

 
219872_at C4orf18 chromosome 4 open reading frame 18 4 -159265181, -159265181 NM_016613 4q32.1 Hs.567498 9

Golgi apparatus

membrane

integral to membrane

 
218364_at LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 3 -37069120 NM_017724 3p22.2 Hs.719246 7

protein binding

cellular_component

biological_process

Wnt receptor signaling pathway

LRR domain binding

 
213400_s_at 0.429 6.514 2.525 2.316e-02 0.506 -3.265 TBL1X transducin (beta)-like 1X-linked X 9391334, 9393200 AV753028 Xp22.3 Hs.495656 16

nucleus

signal transduction

visual perception

sensory perception of sound

modification-dependent protein catabolic process

regulation of transcription

Wnt signaling pathway

1552616_a_at -0.355 5.767 -3.316 4.622e-03 0.334 -1.900 ACACB acetyl-Coenzyme A carboxylase beta 12 108061584 NM_001093 12q24.11 Hs.234898 22

nucleotide binding

acetyl-CoA carboxylase activity

biotin carboxylase activity

ATP binding

cytoplasm

Golgi apparatus

cytosol

fatty acid biosynthetic process

metabolic process

biotin binding

membrane

ligase activity

manganese ion binding

regulation of fatty acid oxidation

metal ion binding

Fatty acid biosynthesis

Pyruvate metabolism

Propanoate metabolism

Metabolic pathways

Insulin signaling pathway

Adipocytokine signaling pathway

243026_x_at 0.231 7.068 2.442 2.730e-02 0.526 -3.403 XIAP X-linked inhibitor of apoptosis X 122821728 BE380045 Xq25 Hs.356076 170

protein binding

intracellular

cytoplasm

cytosol

cytosol

apoptosis

anti-apoptosis

zinc ion binding

ligase activity

modification-dependent protein catabolic process

peptidase inhibitor activity

caspase inhibitor activity

metal ion binding

Ubiquitin mediated proteolysis

Apoptosis

Focal adhesion

Pathways in cancer

Small cell lung cancer

200721_s_at 0.280 7.848 2.419 2.852e-02 0.532 -3.439 ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 10 -104228976 NM_005736 10q24.32 Hs.153961 26

nucleotide binding

protein binding

ATP binding

cytoplasm

centrosome

cytoskeleton

dynactin complex

vesicle-mediated transport

 
226211_at MEG3 maternally expressed 3 (non-protein coding) 14 100362197, 100362215 AI291123 14q32 Hs.525589 Hs.593706 Hs.654863 Hs.655127 11    
200836_s_at 0.461 8.420 3.076 7.582e-03 0.378 -2.321 MAP4 microtubule-associated protein 4 3 -47989573, -47867183, -47867183 NM_002375 3p21 Hs.517949 40

structural molecule activity

protein binding

microtubule

microtubule associated complex

negative regulation of microtubule depolymerization

 
203002_at 0.981 6.784 4.048 1.024e-03 0.225 -0.620 AMOTL2 angiomotin like 2 3 -135556879 NM_016201 3q21-q22 Hs.426312 Hs.713601 9

tight junction

identical protein binding

 
203666_at CXCL12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 10 -44192515, -44191370, -44185610 NM_000609 10q11.1 Hs.522891 435

signal transducer activity

extracellular region

extracellular space

cellular calcium ion homeostasis

chemotaxis

immune response

cell adhesion

signal transduction

G-protein coupled receptor protein signaling pathway

chemokine activity

blood circulation

regulation of actin polymerization or depolymerization

growth factor activity

response to virus

Cytokine-cytokine receptor interaction

Chemokine signaling pathway

Axon guidance

Leukocyte transendothelial migration

1555814_a_at 0.619 9.327 3.608 2.534e-03 0.287 -1.388 RHOA ras homolog gene family, member A 3 -49371582 AF498970 3p21.3 Hs.247077 Hs.709788 348

nucleotide binding

magnesium ion binding

cell morphogenesis

GTPase activity

protein binding

GTP binding

intracellular

nucleus

cytoplasm

cytoskeleton

plasma membrane

regulation of transcription from RNA polymerase II promoter

cell adhesion

cell-matrix adhesion

small GTPase mediated signal transduction

Rho protein signal transduction

skeletal muscle tissue development

myosin binding

actin cytoskeleton organization

cell differentiation

positive regulation of NF-kappaB import into nucleus

positive regulation of I-kappaB kinase/NF-kappaB cascade

negative regulation of neuron apoptosis

interspecies interaction between organisms

negative regulation of neuron differentiation

positive regulation of neuron differentiation

positive regulation of stress fiber formation

Chemokine signaling pathway

Vascular smooth muscle contraction

Wnt signaling pathway

TGF-beta signaling pathway

Axon guidance

Focal adhesion

Adherens junction

Tight junction

T cell receptor signaling pathway

Leukocyte transendothelial migration

Neurotrophin signaling pathway

Regulation of actin cytoskeleton

Pathogenic Escherichia coli infection - EHEC

Pathways in cancer

226782_at -0.849 9.912 -3.393 3.945e-03 0.321 -1.765 SLC25A30 solute carrier family 25, member 30 13 -44865455 BF001919 13q14.13 Hs.591230 3

binding

mitochondrion

mitochondrial inner membrane

transport

mitochondrial transport

membrane

integral to membrane

 
1555600_s_at -0.175 4.705 -2.244 4.012e-02 0.569 -3.723 APOL4 apolipoprotein L, 4 22 -34915121 AF305226 22q11.2-q13.2 Hs.115099 9

molecular_function

extracellular region

lipid metabolic process

lipid transport

lipid binding

lipoprotein metabolic process

 
225643_at MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 14 54588114 AI261542 14q22.3 Hs.594338 Hs.619374 8    
213982_s_at 0.738 4.676 3.063 7.780e-03 0.381 -2.343 RABGAP1L RAB GTPase activating protein 1-like 1 172395256, 173111306 BG107203 1q24 Hs.585378 9

GTPase activator activity

Rab GTPase activator activity

intracellular

regulation of Rab GTPase activity

 
242905_at PNO1 partner of NOB1 homolog (S. cerevisiae) 2 68238508 AV733347 2p14 Hs.262858 8

RNA binding

nucleus

nucleolus

 
222657_s_at 0.562 6.919 2.940 1.001e-02 0.414 -2.557 UBE2W ubiquitin-conjugating enzyme E2W (putative) 8 -74865393 AK024050 8q21.11 Hs.597486 7

nucleotide binding

ubiquitin-protein ligase activity

ATP binding

ligase activity

modification-dependent protein catabolic process

post-translational protein modification

regulation of protein metabolic process

Ubiquitin mediated proteolysis

224461_s_at 0.605 5.674 4.077 9.658e-04 0.223 -0.571 AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 10 -71542035 BC006121 10q22.1 Hs.655377 13

DNA binding

electron-transferring-flavoprotein dehydrogenase activity

electron-transferring-flavoprotein dehydrogenase activity

cytoplasm

mitochondrion

mitochondrial outer membrane

cytosol

induction of apoptosis

apoptotic mitochondrial changes

membrane

integral to membrane

oxidoreductase activity

chromosome condensation

FAD binding

oxidation reduction

 
221217_s_at 0.537 9.440 3.502 3.150e-03 0.304 -1.573 A2BP1 ataxin 2-binding protein 1 16 6009132, 6763810, 7322751 NM_018723 16p13.3 Hs.459842 22

nucleotide binding

RNA binding

nucleus

cytoplasm

trans-Golgi network

mRNA processing

protein C-terminus binding

RNA splicing

RNA transport

 
1565786_x_at FLJ45482 hypothetical LOC645566 7   BQ953917   Hs.644332 1    
225418_at -0.273 6.457 -2.791 1.357e-02 0.438 -2.815 PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 19 50041232, 50041232 AI520949 19q13.2 Hs.655455 38

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

positive regulation of immunoglobulin mediated immune response

plasma membrane

cell-cell junction

zonula adherens

cell adhesion

homophilic cell adhesion

spermatid development

cell surface

coreceptor activity

integral to membrane

viral envelope fusion with host membrane

positive regulation of mast cell activation

susceptibility to natural killer cell mediated cytotoxicity

virion attachment, binding of host cell surface coreceptor

cell adhesion molecule binding

adhesion to symbiont

susceptibility to T cell mediated cytotoxicity

Cell adhesion molecules (CAMs)

Adherens junction

230943_at -0.494 3.688 -2.574 2.098e-02 0.497 -3.182 SOX17 SRY (sex determining region Y)-box 17 8 55533047 AI821669 8q11.23 Hs.98367 15

angiogenesis

vasculogenesis

DNA binding

nucleus

beta-catenin binding

transcription factor binding

negative regulation of Wnt receptor signaling pathway

protein destabilization

regulation of transcription

protein stabilization

Wnt signaling pathway

224314_s_at 0.495 5.655 2.509 2.391e-02 0.509 -3.292 EGLN1 egl nine homolog 1 (C. elegans) 1 -229566120 AF277174 1q42.1 Hs.444450 Hs.710300 42

response to hypoxia

embryonic placenta development

iron ion binding

protein binding

cytosol

heart development

zinc ion binding

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

L-ascorbic acid binding

peptidyl-proline dioxygenase activity

oxygen homeostasis

negative regulation of transcription factor activity

metal ion binding

oxidation reduction

Pathways in cancer

Renal cell carcinoma

218517_at PHF17 PHD finger protein 17 4 129950228, 129950228 NM_024900 4q26-q27 Hs.12420 14

histone acetyltransferase complex

protein binding

nucleus

cytoplasm

apoptosis

response to stress

zinc ion binding

negative regulation of cell growth

histone H3 acetylation

histone H4-K5 acetylation

histone H4-K8 acetylation

histone H4-K12 acetylation

histone H4-K16 acetylation

regulation of transcription

metal ion binding

 
227279_at 0.616 7.300 2.729 1.537e-02 0.457 -2.920 TCEAL3 transcription elongation factor A (SII)-like 3 X 102749489 AA847654 Xq22.2 Hs.311776 6

nucleus

regulation of transcription

 
222989_s_at UBQLN1 ubiquilin 1 9 -85464697 NM_013438 9q21.2-q21.3 9q22 Hs.9589 46

nucleus

cytoplasm

cytosol

kinase binding

protein complex

perinuclear region of cytoplasm

 
206461_x_at 1.062 10.334 4.843 2.067e-04 0.172 0.717 MT1H metallothionein 1H 16 55261226 NM_005951 16q13 Hs.438462 16

copper ion binding

protein binding

zinc ion binding

cadmium ion binding

metal ion binding

 
200098_s_at ANAPC5 anaphase promoting complex subunit 5 12 -120230432, -120230432 T33068 12q24.31 Hs.7101 28

G2/M transition of mitotic cell cycle

mitotic anaphase

ubiquitin-protein ligase activity

binding

nucleoplasm

anaphase-promoting complex

cytosol

ubiquitin-dependent protein catabolic process

cell cycle

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

cell division

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Cell cycle

Ubiquitin mediated proteolysis

238613_at ZAK sterile alpha motif and leucine zipper containing kinase AZK 2 173648810, 173648810 AI475164 2q24.2 Hs.444451 24

cell cycle checkpoint

DNA damage checkpoint

nucleotide binding

activation of MAPKK activity

magnesium ion binding

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

protein tyrosine kinase activity

ATP binding

nucleus

cytoplasm

response to stress

cell cycle

cell cycle arrest

protein kinase cascade

activation of JUN kinase activity

cell death

cell proliferation

response to radiation

transferase activity

cell differentiation

identical protein binding

positive regulation of apoptosis

MAPK signaling pathway

Tight junction

221497_x_at 0.444 7.147 2.292 3.660e-02 0.560 -3.647 EGLN1 egl nine homolog 1 (C. elegans) 1 -229566120 BC005369 1q42.1 Hs.444450 Hs.710300 42

response to hypoxia

embryonic placenta development

iron ion binding

protein binding

cytosol

heart development

zinc ion binding

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

L-ascorbic acid binding

peptidyl-proline dioxygenase activity

oxygen homeostasis

negative regulation of transcription factor activity

metal ion binding

oxidation reduction

Pathways in cancer

Renal cell carcinoma

207154_at DIO3 deiodinase, iodothyronine, type III 14 101097440 NM_001362 14q32 Hs.49322 19

thyroxine 5'-deiodinase activity

cellular_component

endosome

plasma membrane

biological_process

selenium binding

integral to membrane

thyroxine 5-deiodinase activity

positive regulation of multicellular organism growth

thyroid hormone catabolic process

hormone biosynthetic process

oxidation reduction

 
217997_at 0.476 3.562 3.074 7.608e-03 0.378 -2.324 PHLDA1 pleckstrin homology-like domain, family A, member 1 12 -74705493 AI795908 12q15 Hs.602085 15

protein binding

nucleus

nucleolus

cytoplasm

apoptosis

membrane

cytoplasmic vesicle membrane

cytoplasmic vesicle

FasL biosynthetic process

 
217681_at WNT7B wingless-type MMTV integration site family, member 7B 22 -44694913 BE736994 22q13 Hs.512714 10

signal transducer activity

extracellular matrix structural constituent

extracellular region

proteinaceous extracellular matrix

Wnt receptor signaling pathway, calcium modulating pathway

cell-cell signaling

multicellular organismal development

organ morphogenesis

positive regulation of osteoblast differentiation

synapse organization

Wnt signaling pathway

Hedgehog signaling pathway

Melanogenesis

Pathways in cancer

Basal cell carcinoma

40687_at -0.352 6.474 -2.953 9.763e-03 0.408 -2.536 GJA4 gap junction protein, alpha 4, 37kDa 1 35031185 M96789 1p35.1 Hs.296310 47

blood vessel development

plasma membrane

integral to plasma membrane

connexon complex

transport

cell-cell junction assembly

cell communication

cell junction

 
218984_at 0.351 6.570 2.486 2.499e-02 0.513 -3.329 PUS7 pseudouridylate synthase 7 homolog (S. cerevisiae) 7 -104884195 NM_019042 7q22.3 Hs.520619 5

pseudouridine synthesis

RNA binding

tRNA processing

pseudouridine synthase activity

isomerase activity

 
209503_s_at 0.285 9.753 2.442 2.726e-02 0.526 -3.402 PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 17 59258541 AF035309 17q23-q25 Hs.79387 71

nucleotide binding

proteasome complex

transcription cofactor activity

ATP binding

nucleus

nucleolus

cytoplasm

cytosol

transcription from RNA polymerase II promoter

hydrolase activity

ATPase activity

protein catabolic process

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

thyrotropin-releasing hormone receptor binding

negative regulation of programmed cell death

positive regulation of gene-specific transcription

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

210330_at 0.365 4.597 2.224 4.169e-02 0.573 -3.754 SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 5 155686344, 155686344 U58331 5q33-q34 Hs.387207 Hs.644733 29

protein binding

cytoplasm

cytoskeleton

plasma membrane

cytoskeleton organization

muscle organ development

sarcoglycan complex

integral to membrane

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

218883_s_at MLF1IP MLF1 interacting protein 4 -185852213 NM_024629 4q35.1 Hs.575032 16

condensed chromosome kinetochore

protein binding

nucleus

chromosome

cytoplasm

interspecies interaction between organisms

regulation of transcription

 
226466_s_at 0.332 7.202 2.511 2.379e-02 0.509 -3.288 FAM58A family with sequence similarity 58, member A X -152506576 AL544688 Xq28 Hs.496943 Hs.659433 6    
220539_at 0.509 6.761 2.584 2.059e-02 0.497 -3.166 C10orf92 chromosome 10 open reading frame 92 10 -134471886 NM_017609 10q26.3 Hs.298038 6    
91703_at EHBP1L1 EH domain binding protein 1-like 1 11 65100084 AA149545 11q13.1 Hs.502867 4    
200749_at RAN RAN, member RAS oncogene family 12 129922569 BF112006 12q24.3 Hs.10842 132

nucleotide binding

chromatin

chromatin binding

transcription coactivator activity

GTPase activity

GTPase activity

protein binding

GTP binding

nucleus

nuclear pore

nucleoplasm

cytoplasm

cytosol

DNA metabolic process

RNA export from nucleus

protein export from nucleus

intracellular protein transport

nucleocytoplasmic transport

mitotic spindle organization

mitosis

signal transduction

androgen receptor signaling pathway

melanosome

interspecies interaction between organisms

positive regulation of transcription, DNA-dependent

androgen receptor binding

 
202500_at 0.246 8.154 2.332 3.386e-02 0.552 -3.582 DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2 219852283 NM_006736 2q32-q34 Hs.77768 17

protein folding

response to unfolded protein

heat shock protein binding

unfolded protein binding

 
201955_at 0.517 7.090 4.042 1.037e-03 0.225 -0.631 CCNC cyclin C 6 -100096983 AL137784 6q21 Hs.430646 Hs.633351 31

protein binding

nucleus

regulation of transcription

 
205417_s_at 0.274 9.122 2.493 2.466e-02 0.513 -3.318 DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 3 49482568 NM_004393 3p21 Hs.707131 Hs.76111 56

morphogenesis of an epithelial sheet

calcium ion binding

protein binding

extracellular region

basement membrane

extracellular space

membrane fraction

cytoplasm

integral to plasma membrane

protein complex assembly

muscle contraction

actin cytoskeleton

dystroglycan complex

sarcolemma

membrane raft

ECM-receptor interaction

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

228363_at XIAP X-linked inhibitor of apoptosis X 122821728 BF109251 Xq25 Hs.356076 170

protein binding

intracellular

cytoplasm

cytosol

cytosol

apoptosis

anti-apoptosis

zinc ion binding

ligase activity

modification-dependent protein catabolic process

peptidase inhibitor activity

caspase inhibitor activity

metal ion binding

Ubiquitin mediated proteolysis

Apoptosis

Focal adhesion

Pathways in cancer

Small cell lung cancer

233403_x_at TM6SF2 transmembrane 6 superfamily member 2 19 -19236173 AK026307 19p13.3-p12 Hs.531624 6

molecular_function

biological_process

membrane

integral to membrane

 
202861_at PER1 period homolog 1 (Drosophila) 17 -7984512 NM_002616 17p13.1-p12 Hs.445534 54

signal transducer activity

nucleus

cytoplasm

regulation of transcription, DNA-dependent

signal transduction

circadian rhythm

entrainment of circadian clock

negative regulation of transcription

Circadian rhythm - mammal

34471_at MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 17 -10234366 M36769 17p13.1 Hs.700484 10

nucleotide binding

motor activity

actin binding

calmodulin binding

ATP binding

cytoplasm

striated muscle thick filament

striated muscle contraction

structural constituent of muscle

myosin complex

myofibril

Tight junction

202009_at TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila) 3 -52237665 NM_007284 3p21.1 Hs.436439 9

actin binding

protein binding

ATP binding

intracellular

cytoplasm

cytoskeleton

perinuclear region of cytoplasm

 
204204_at SLC31A2 solute carrier family 31 (copper transporters), member 2 9 114953058 NM_001860 9q31-q32 Hs.24030 7

copper ion transmembrane transporter activity

copper ion binding

integral to plasma membrane

ion transport

copper ion transport

membrane

 
223013_at 0.301 9.210 2.544 2.228e-02 0.500 -3.233 TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 3 -178221235 AF267864 3q26.32 Hs.715537 14

nucleus

chromatin modification

modification-dependent protein catabolic process

regulation of transcription

Wnt signaling pathway

224177_s_at CXorf26 chromosome X open reading frame 26 X 75309172 AF151079 Xq13.3 Hs.370100 6

molecular_function

cellular_component

biological_process

 
214093_s_at FUBP1 far upstream element (FUSE) binding protein 1 1 -78186178 AA156865 1p31.1 Hs.567380 28

single-stranded DNA binding

transcription factor activity

RNA binding

protein binding

nucleus

nucleolus

transcription from RNA polymerase II promoter

regulation of transcription

 
239213_at -0.270 4.754 -2.398 2.972e-02 0.536 -3.474 SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 6 -2778732 W52010 6p25 Hs.381167 18

serine-type endopeptidase inhibitor activity

cytoplasm

peptidase inhibitor activity

 
1562264_at -0.268 3.463 -2.965 9.525e-03 0.403 -2.515 LOC339685 hypothetical protein LOC339685 22   BC043000 22q13.31 Hs.434351 1    
218631_at 0.381 5.876 3.029 8.350e-03 0.388 -2.403 AVPI1 arginine vasopressin-induced 1 10 -99427170 NM_021732 10q24.2 Hs.23918 9

cell cycle

 
1554565_x_at -0.289 6.547 -2.761 1.441e-02 0.447 -2.866 UNQ1887 signal peptide peptidase 3 12 -119685417 BC011943 12q24.31 Hs.507087 Hs.683964 12

aspartic-type endopeptidase activity

peptidase activity

membrane

integral to membrane

 
202211_at ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 22 -41522475 BC005122 22q13.2-q13.3 Hs.162877 15

cytoplasm

Golgi apparatus

cytosol

intracellular protein transport

ARF GTPase activator activity

zinc ion binding

protein transporter activity

protein secretion

membrane

vesicle-mediated transport

regulation of ARF GTPase activity

metal ion binding

Endocytosis

208722_s_at 0.443 7.308 2.902 1.084e-02 0.421 -2.624 ANAPC5 anaphase promoting complex subunit 5 12 -120230432, -120230432 BC001081 12q24.31 Hs.7101 28

G2/M transition of mitotic cell cycle

mitotic anaphase

ubiquitin-protein ligase activity

binding

nucleoplasm

anaphase-promoting complex

cytosol

ubiquitin-dependent protein catabolic process

cell cycle

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

cell division

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Cell cycle

Ubiquitin mediated proteolysis

205150_s_at 0.765 5.425 3.974 1.191e-03 0.233 -0.748 KIAA0644 KIAA0644 gene product 7 -28959498 AV724192 7p14.3 Hs.719240 4

protein binding

membrane

integral to membrane

 
200835_s_at MAP4 microtubule-associated protein 4 3 -47989573, -47867183, -47867183 AI553791 3p21 Hs.517949 40

structural molecule activity

protein binding

microtubule

microtubule associated complex

negative regulation of microtubule depolymerization

 
209750_at -1.553 6.636 -3.274 5.044e-03 0.345 -1.974 NR1D2 nuclear receptor subfamily 1, group D, member 2 3 23961754, 23962615 N32859 3p24.2 Hs.37288 13

transcription factor activity

steroid hormone receptor activity

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
235539_at NUMA1 nuclear mitotic apparatus protein 1 11 -71391558 AW964431 11q13 Hs.325978 47

mitotic anaphase

spindle pole

structural molecule activity

protein binding

nucleus

spindle microtubule

nucleus organization

microtubule binding

nuclear matrix

dendrite

cell soma

meiotic cell cycle

 
221252_s_at GSG1 germ cell associated 1 12 -13128308, -13128308 NM_031289 12p13.1 Hs.240053 7

endoplasmic reticulum

membrane

integral to membrane

 
227418_at KIAA1826 KIAA1826 11 -105383838 AI808746 11q22 Hs.266782 8

nucleus

 
1553267_a_at -0.208 2.281 -2.482 2.522e-02 0.514 -3.337 CNOT6L CCR4-NOT transcription complex, subunit 6-like 4 -78853564 NM_144571 4q13.3 Hs.592519 5

exonuclease activity

protein binding

cytoplasm

mRNA processing

hydrolase activity

RNA degradation

229026_at CDC42SE2 CDC42 small effector 2 5 130627600 BE675995 5q23.3-q31.1 Hs.508829 Hs.713870 8

structural molecule activity

protein binding

cytoplasm

cytoskeleton

plasma membrane

phagocytosis

regulation of cell shape

regulation of signal transduction

 
203977_at TAZ tafazzin X 153293070 NM_000116 Xq28 Hs.409911 35

cytoplasm

mitochondrion

mitochondrion

muscle contraction

skeletal muscle tissue development

metabolic process

acyltransferase activity

membrane

integral to membrane

hemopoiesis

cardiolipin biosynthetic process

mitochondrial respiratory chain complex I assembly

cristae formation

mitochondrial ATP synthesis coupled electron transport

1-acylglycerophosphocholine O-acyltransferase activity

cardiac muscle tissue development

cardiac muscle contraction

 
222693_at 0.320 3.374 2.711 1.593e-02 0.459 -2.950 FNDC3B fibronectin type III domain containing 3B 3 173240111, 173241037 BF444916 3q26.31 Hs.159430 9

endoplasmic reticulum

membrane

integral to membrane

 
1553895_at C11orf42 chromosome 11 open reading frame 42 11 6183373 NM_173525 11p15.4 Hs.278221 2    
217870_s_at CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 1 47572055 NM_016308 1p32 Hs.714325 16

nucleotide binding

cytidylate kinase activity

uridine kinase activity

ATP binding

nucleus

cytoplasm

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

pyrimidine ribonucleotide biosynthetic process

transferase activity

phosphotransferase activity, phosphate group as acceptor

Pyrimidine metabolism

Metabolic pathways

201198_s_at 0.452 8.426 2.905 1.075e-02 0.420 -2.618 PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 2 231629852 AI860431 2q37.1 Hs.3887 43

proteasome complex

protein binding

cytosol

proteasome regulatory particle

enzyme regulator activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

212717_at 0.285 6.963 2.710 1.599e-02 0.459 -2.954 PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 17 -40869048 AB002354 17q21.31 Hs.514242 7

cytoplasm

intracellular signaling cascade

zinc ion binding

diacylglycerol binding

metal ion binding

 
202154_x_at TUBB3 tubulin, beta 3 16 88517245 NM_006086 16q24.3 Hs.511743 41

nucleotide binding

GTPase activity

structural molecule activity

GTP binding

intracellular

microtubule

microtubule-based movement

mitosis

neuron differentiation

axon

protein complex

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

226089_at RABL3 RAB, member of RAS oncogene family-like 3 3 -121888217 AI742028 3q13.33 Hs.444360 1

nucleotide binding

GTP binding

intracellular

small GTPase mediated signal transduction

 
226164_x_at 0.560 5.187 2.970 9.419e-03 0.401 -2.505 RIMKLB ribosomal modification protein rimK-like family member B 12 8741784 AI760919 12p13.31 Hs.504670 4

nucleotide binding

catalytic activity

ATP binding

protein modification process

manganese ion binding

metal ion binding

 
222154_s_at 0.421 9.172 2.412 2.894e-02 0.534 -3.452 SPATS2L spermatogenesis associated, serine-rich 2-like 2 200878848, 200879229, 200879600 AK002064 2q33.1 Hs.120323 9    
211969_at HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 14 -101616827, -101616827 BG420237 14q32.33 Hs.525600 Hs.700831 275

nucleotide binding

ATP binding

cytoplasm

cytosol

cytosol

mitochondrial transport

response to unfolded protein

signal transduction

nitric-oxide synthase regulator activity

TPR domain binding

TPR domain binding

cellular chaperone-mediated protein complex assembly

protein refolding

melanosome

protein homodimerization activity

positive regulation of nitric oxide biosynthetic process

unfolded protein binding

mitochondrial outer membrane translocase complex assembly

Antigen processing and presentation

Pathways in cancer

Prostate cancer

230284_at 0.709 6.234 2.826 1.264e-02 0.429 -2.755 MYOM3 myomesin family, member 3 1 -24255117 BF108688 1p36.11 Hs.523413 4    
1552879_a_at -0.354 3.964 -3.471 3.360e-03 0.308 -1.628 ATOH7 atonal homolog 7 (Drosophila) 10 -69660387 BC032621 10q21.3 10q21.3-q22.1 Hs.175396 4

DNA binding

nucleus

multicellular organismal development

nervous system development

circadian rhythm

entrainment of circadian clock

cell differentiation

transcription regulator activity

regulation of transcription

 
41037_at TEAD4 TEA domain family member 4 12 2938756, 2939222 U63824 12p13.3-p13.2 Hs.94865 16

skeletal system development

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

regulation of transcription from RNA polymerase II promoter

muscle organ development

 
205402_x_at PRSS2 protease, serine, 2 (trypsin 2) 7 142178777 NM_002770 7q34 Hs.622865 39

serine-type endopeptidase activity

calcium ion binding

protein binding

extracellular region

extracellular space

proteolysis

digestion

peptidase activity

positive regulation of cell growth

collagen catabolic process

collagen catabolic process

extracellular matrix

positive regulation of cell adhesion

Neuroactive ligand-receptor interaction

212338_at 0.716 2.782 3.770 1.814e-03 0.270 -1.104 MYO1D myosin ID 17 -27843740 AA621962 17q11-q12 Hs.658000 7

nucleotide binding

motor activity

actin binding

calmodulin binding

ATP binding

myosin complex

 
212712_at CAMSAP1 calmodulin regulated spectrin-associated protein 1 9 -137840153 BE222901 9q34.3 Hs.522493 2    
211758_x_at TXNDC9 thioredoxin domain containing 9 2 -99301918 BC005968 2q11.2 Hs.536122 8

protein binding

cellular_component

biological_process

 
214473_x_at 0.287 6.323 2.308 3.543e-02 0.556 -3.620 PMS2L3 postmeiotic segregation increased 2-like 3 7 -74975005, -74975004 NM_005395 7q11.23 Hs.406395 Hs.659871 Hs.661055 4

molecular_function

nucleic acid binding

ATP binding

cellular_component

intracellular

regulation of transcription, DNA-dependent

biological_process

 
222918_at 0.419 7.490 2.282 3.726e-02 0.562 -3.662 RAB9B RAB9B, member RAS oncogene family X -102966606 AL139228 Xq22.1-q22.3 Hs.522736 Hs.679046 5

nucleotide binding

protein binding

GTP binding

cellular_component

plasma membrane

Golgi to endosome transport

small GTPase mediated signal transduction

protein transport

 
227277_at MTDH metadherin 8 98725582 BG530089 8q22.1 Hs.377155 23

negative regulation of transcription from RNA polymerase II promoter

protein binding

nucleus

nucleolus

cytoplasm

endoplasmic reticulum

tight junction

membrane

integral to membrane

cell junction

nuclear membrane

perinuclear region of cytoplasm

NF-kappaB binding

positive regulation of NF-kappaB transcription factor activity

 
235653_s_at 0.884 5.193 4.015 1.095e-03 0.227 -0.677 THAP6 THAP domain containing 6 4 76658677 BF685315 4q21.1 Hs.479971 10

DNA binding

zinc ion binding

microtubule cytoskeleton

metal ion binding

 
219603_s_at 0.370 4.885 2.579 2.078e-02 0.497 -3.174 ZNF226 zinc finger protein 226 19 49361088, 49361088, 49361096, 49361156 NM_015919 19q13.2 Hs.145956 6

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
1554574_a_at 0.549 5.646 3.857 1.517e-03 0.253 -0.953 CYB5R3 cytochrome b5 reductase 3 22 -41344757, -41344757 AF361370 22q13.2-q13.31 22q13.31-qter Hs.700572 49

cytochrome-b5 reductase activity

cytoplasm

mitochondrion

mitochondrial outer membrane

mitochondrial inner membrane

endoplasmic reticulum

endoplasmic reticulum membrane

hemoglobin complex

cholesterol biosynthetic process

blood circulation

electron carrier activity

membrane

oxidoreductase activity

oxidation reduction

Amino sugar and nucleotide sugar metabolism

225756_at -0.301 5.821 -2.981 9.210e-03 0.400 -2.486 CSNK1E casein kinase 1, epsilon 22 -37016642, -37016642 AV762065 22q13.1 Hs.474833 65

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

cytoplasm

DNA repair

protein amino acid phosphorylation

signal transduction

transferase activity

Wnt signaling pathway

Hedgehog signaling pathway

Circadian rhythm - mammal

214987_at -0.326 5.482 -3.195 5.940e-03 0.357 -2.113 GAB1 GRB2-associated binding protein 1 4 144477432 AL049449 4q31.21 Hs.618456 Hs.80720 69

SH3/SH2 adaptor activity

protein binding

cytosol

epidermal growth factor receptor signaling pathway

cell proliferation

insulin receptor signaling pathway

ErbB signaling pathway

Neurotrophin signaling pathway

Renal cell carcinoma

220606_s_at C17orf48 chromosome 17 open reading frame 48 17 10541651 NM_020233 17p13.1 Hs.47668 Hs.708369 2

zinc ion binding

hydrolase activity

metal ion binding

ADP-ribose diphosphatase activity

CDP-glycerol diphosphatase activity

 
200840_at -0.815 11.286 -4.192 7.628e-04 0.211 -0.372 KARS lysyl-tRNA synthetase 16 -74219122 NM_005548 16q23-q24 Hs.3100 30

nucleotide binding

nucleic acid binding

lysine-tRNA ligase activity

ATP binding

soluble fraction

cytoplasm

lysyl-tRNA aminoacylation

ligase activity

Aminoacyl-tRNA biosynthesis

209276_s_at 1.021 9.119 3.914 1.349e-03 0.245 -0.853 GLRX glutaredoxin (thioltransferase) 5 -95175308 AF162769 5q14 Hs.28988 Hs.712696 47

cytoplasm

cytosol

transport

electron carrier activity

protein disulfide oxidoreductase activity

glutathione disulfide oxidoreductase activity

electron transport chain

cell redox homeostasis

protein N-terminus binding

 
203115_at 0.816 5.892 3.555 2.823e-03 0.294 -1.480 FECH ferrochelatase (protoporphyria) 18 -53363070 AU152635 18q21.3 Hs.365365 61

ferrochelatase activity

ferrochelatase activity

protein binding

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

generation of precursor metabolites and energy

heme biosynthetic process

ferrous iron binding

response to light stimulus

detection of UV

membrane

protoporphyrinogen IX metabolic process

metal ion binding

2 iron, 2 sulfur cluster binding

Porphyrin and chlorophyll metabolism

Metabolic pathways

210290_at 0.541 4.178 4.857 2.010e-04 0.172 0.739 ZNF174 zinc finger protein 174 16 3391190, 3391190 BC001161 16p13.3 Hs.155204 9

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

protein binding

intracellular

nucleus

nucleolus

cytoplasm

cytoskeleton

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
214113_s_at RBM8A RNA binding motif protein 8A 1 144218994 AI738479 1q12 Hs.356873 43

nucleotide binding

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nuclear mRNA splicing, via spliceosome

mRNA binding

protein binding

nucleus

spliceosomal complex

cytoplasm

transport

biological_process

RNA splicing

nuclear speck

exon-exon junction complex

mRNA transport

 
227421_at 0.619 6.392 2.264 3.861e-02 0.567 -3.691 C21orf57 chromosome 21 open reading frame 57 21 46530694, 46530694 BF026326 21q22.3 Hs.474066 4

peptidase activity

metallopeptidase activity

zinc ion binding

metal ion binding

 
223853_at 0.601 4.122 3.132 6.759e-03 0.368 -2.223 BVES blood vessel epicardial substance 6 -105651391, -105651391 AF204172 6q21 Hs.221660 6

muscle organ development

membrane

integral to membrane

 
221810_at RAB15 RAB15, member RAS onocogene family 14 -64482284 AA631242 14q23.3 Hs.512492 11

nucleotide binding

GTP binding

plasma membrane

small GTPase mediated signal transduction

protein transport

 
212435_at TRIM33 tripartite motif-containing 33 1 -114736921 AA205593 1p13.1 Hs.26837 12

DNA binding

protein binding

intracellular

nucleus

zinc ion binding

negative regulation of transcription

protein ubiquitination

ligase activity

regulation of transforming growth factor beta receptor signaling pathway

modification-dependent protein catabolic process

negative regulation of BMP signaling pathway

metal ion binding

co-SMAD binding

R-SMAD binding

 
211593_s_at 0.249 7.952 2.322 3.451e-02 0.553 -3.598 MAST2 microtubule associated serine/threonine kinase 2 1 46041871 AB047005 1p34.1 Hs.319481 19

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

cytoskeleton

plasma membrane

protein amino acid phosphorylation

transferase activity

phosphatase binding

regulation of interleukin-12 biosynthetic process

spermatid differentiation

 
33778_at TBC1D22A TBC1 domain family, member 22A 22 45537212 AL096779 22q13.3 Hs.435044 9

GTPase activator activity

Rab GTPase activator activity

intracellular

regulation of Rab GTPase activity

 
225658_at SPOPL speckle-type POZ protein-like 2 138975819 BF034206 2q22.1 Hs.333297 6

protein binding

nucleus

modification-dependent protein catabolic process

 
229889_at C17orf76 chromosome 17 open reading frame 76 17 -16286052 AW137009 17p11.2 Hs.25425 1    
1562337_at 0.503 4.318 2.500 2.430e-02 0.512 -3.306 OR7D2 olfactory receptor, family 7, subfamily D, member 2 19 9157269 AK095468 19p13.2 Hs.531755 4

receptor activity

olfactory receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

sensory perception of smell

integral to membrane

response to stimulus

Olfactory transduction

203742_s_at 0.381 5.727 2.775 1.402e-02 0.443 -2.843 TDG thymine-DNA glycosylase 12 102883722 BF674842 12q24.1 Hs.584809 47

damaged DNA binding

protein binding

nucleus

nucleoplasm

nucleoplasm

base-excision repair

mismatch repair

response to DNA damage stimulus

metabolic process

pyrimidine-specific mismatch base pair DNA N-glycosylase activity

DNA N-glycosylase activity

mismatched DNA binding

depyrimidination

Base excision repair

206443_at -0.349 3.757 -2.826 1.264e-02 0.429 -2.755 RORB RAR-related orphan receptor B 9 76302071 NM_006914 9q22 Hs.494178 16

transcription factor activity

steroid hormone receptor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

visual perception

zinc ion binding

eye photoreceptor cell development

positive regulation of gene-specific transcription

sequence-specific DNA binding

metal ion binding

response to stimulus

 
46665_at SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 2 -96889199 AI949392 2q11.2 Hs.516220 9

receptor activity

protein binding

multicellular organismal development

nervous system development

membrane

integral to membrane

cell differentiation

Axon guidance

203837_at -0.663 6.437 -2.423 2.829e-02 0.531 -3.433 MAP3K5 mitogen-activated protein kinase kinase kinase 5 6 -136919879 NM_005923 6q22.33 Hs.186486 108

MAPKKK cascade

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

ATP binding

protein amino acid phosphorylation

apoptosis

activation of JUN kinase activity

induction of apoptosis by extracellular signals

caspase activator activity

transferase activity

protein homodimerization activity

interspecies interaction between organisms

MAPK signaling pathway

Neurotrophin signaling pathway

Amyotrophic lateral sclerosis (ALS)

218184_at TULP4 tubby like protein 4 6 158653679 NM_020245 6q25-q26 Hs.486993 7

transcription factor activity

protein binding

cellular_component

cytoplasm

regulation of transcription, DNA-dependent

intracellular signaling cascade

response to nutrient

modification-dependent protein catabolic process

 
203008_x_at 0.316 7.997 2.148 4.818e-02 0.588 -3.873 TXNDC9 thioredoxin domain containing 9 2 -99301918 NM_005783 2q11.2 Hs.536122 8

protein binding

cellular_component

biological_process

 
204446_s_at 0.810 3.702 5.503 5.770e-05 0.162 1.755 ALOX5 arachidonate 5-lipoxygenase 10 45189634 NM_000698 10q11.2 Hs.89499 141

arachidonate 5-lipoxygenase activity

iron ion binding

calcium ion binding

protein binding

nucleus

nuclear envelope lumen

cytoplasm

cytosol

inflammatory response

membrane

lipoxygenase activity

nuclear matrix

oxidoreductase activity

leukotriene biosynthetic process

nuclear membrane

oxidation reduction

Arachidonic acid metabolism

Linoleic acid metabolism

Metabolic pathways

225216_at CXorf39 chromosome X open reading frame 39 X 103297956 AI590719 Xq22.2 Hs.496535 Hs.592223 5    
238664_s_at -0.193 4.773 -2.426 2.813e-02 0.529 -3.428 MGC12916 hypothetical protein MGC12916 17 14147781 BF205828 17p12 Hs.597458      
222510_s_at 0.670 6.259 4.426 4.748e-04 0.193 0.026 MKRN2 makorin ring finger protein 2 3 12573593 AI809203 3p25 Hs.591666 5

molecular_function

nucleic acid binding

protein binding

intracellular

biological_process

zinc ion binding

metal ion binding

 
201646_at 0.573 7.181 2.697 1.639e-02 0.464 -2.975 SCARB2 scavenger receptor class B, member 2 4 -77298917 AA885297 4q21.1 Hs.349656 Hs.714206 24

receptor activity

protein binding

membrane fraction

lysosome

integral to plasma membrane

cell adhesion

membrane

Lysosome

203282_at 0.628 10.895 3.736 1.946e-03 0.273 -1.164 GBE1 glucan (1,4-alpha-), branching enzyme 1 3 -81621539 NM_000158 3p12.3 Hs.436062 20

1,4-alpha-glucan branching enzyme activity

1,4-alpha-glucan branching enzyme activity

hydrolase activity, hydrolyzing O-glycosyl compounds

cytosol

carbohydrate metabolic process

glycogen biosynthetic process

generation of precursor metabolites and energy

transferase activity, transferring glycosyl groups

cation binding

Starch and sucrose metabolism

Metabolic pathways

200983_x_at CD59 CD59 molecule, complement regulatory protein 11 -33681131, -33681131, -33681131 BF983379 11p13 Hs.278573 Hs.709466 Hs.710641 107

protein binding

extracellular region

membrane fraction

plasma membrane

cell surface receptor linked signal transduction

blood coagulation

anchored to membrane

anchored to external side of plasma membrane

Complement and coagulation cascades

Hematopoietic cell lineage

222612_at PSPC1 paraspeckle component 1 13 -19175008, -19146895 N32583 13q12.11 Hs.213198 9

nucleotide binding

RNA binding

protein binding

nucleus

nucleolus

cytoplasm

nuclear matrix

regulation of transcription

 
205174_s_at 2.051 4.526 4.379 5.229e-04 0.206 -0.055 QPCT glutaminyl-peptide cyclotransferase 2 37425256 NM_012413 2p22.2 Hs.79033 15

protein modification process

proteolysis

peptidase activity

zinc ion binding

acyltransferase activity

glutaminyl-peptide cyclotransferase activity

transferase activity

metal ion binding

 
221234_s_at 0.741 4.931 3.255 5.250e-03 0.348 -2.008 BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 6 -90692968 NM_021813 6q15 Hs.269764 Hs.716609 Hs.716710 23

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

sequence-specific DNA binding

protein dimerization activity

 
228121_at 0.864 6.720 2.730 1.534e-02 0.457 -2.919 TGFB2 transforming growth factor, beta 2 1 216586013 AU145950 1q41 Hs.133379 112

cell morphogenesis

skeletal system development

cartilage condensation

angiogenesis

beta-amyloid binding

blood vessel development

eye development

response to hypoxia

blood vessel remodeling

receptor signaling protein serine/threonine kinase activity

type II transforming growth factor beta receptor binding

type II transforming growth factor beta receptor binding

cytokine activity

extracellular region

extracellular region

extracellular region

extracellular space

induction of apoptosis

activation-induced cell death of T cells

cell cycle arrest

transforming growth factor beta receptor signaling pathway

SMAD protein nuclear translocation

cell-cell signaling

axon guidance

salivary gland morphogenesis

growth factor activity

cell death

positive regulation of cell proliferation

glial cell migration

embryonic development

positive regulation of epithelial cell migration

negative regulation of alkaline phosphatase activity

positive regulation of epithelial to mesenchymal transition

positive regulation of phosphoinositide 3-kinase cascade

menstrual cycle phase

hemopoiesis

collagen fibril organization

positive regulation of cell growth

negative regulation of cell growth

axon

neutrophil chemotaxis

neutrophil chemotaxis

extracellular matrix

hair follicle morphogenesis

platelet alpha granule lumen

activation of protein kinase activity

response to progesterone stimulus

positive regulation of stress-activated MAPK cascade

regulation of transforming growth factor-beta2 production

positive regulation of cell adhesion mediated by integrin

wound healing

dopamine biosynthetic process

odontogenesis

protein homodimerization activity

cell soma

positive regulation of neuron apoptosis

cell-cell junction organization

positive regulation of integrin biosynthetic process

positive regulation of ossification

positive regulation of cell cycle

positive regulation of heart contraction

protein heterodimerization activity

somatic stem cell division

neuron fate commitment

neuron development

generation of neurons

negative regulation of epithelial cell proliferation

negative regulation of epithelial cell proliferation

positive regulation of protein secretion

negative regulation of immune response

positive regulation of immune response

positive regulation of catagen

positive regulation of cardioblast differentiation

cardiac muscle cell proliferation

cardiac epithelial to mesenchymal transition

pathway-restricted SMAD protein phosphorylation

MAPK signaling pathway

Cytokine-cytokine receptor interaction

Cell cycle

TGF-beta signaling pathway

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Chronic myeloid leukemia

Hypertrophic cardiomyopathy (HCM)

206718_at -0.458 8.041 -2.484 2.508e-02 0.513 -3.332 LMO1 LIM domain only 1 (rhombotin 1) 11 -8202432 NM_002315 11p15 Hs.654426 21

transcription factor activity

nucleus

multicellular organismal development

zinc ion binding

cell proliferation

metal ion binding

 
215818_at -0.257 4.591 -2.774 1.405e-02 0.444 -2.844 NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7 16 76313911, 76313911 AK026469 16q23.1 Hs.719356 2

magnesium ion binding

peroxisome

nucleoside diphosphate metabolic process

hydrolase activity

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

manganese ion binding

 
219058_x_at TINAGL1 tubulointerstitial nephritis antigen-like 1 1 31814672 NM_022164 1p35.2 Hs.199368 14

cysteine-type endopeptidase activity

extracellular matrix structural constituent

extracellular region

proteolysis

endosome transport

 
219805_at -0.514 6.465 -3.469 3.372e-03 0.308 -1.631 CXorf56 chromosome X open reading frame 56 X -118557528 NM_022101 Xq23 Hs.248572 3

protein binding

 
209360_s_at 1.082 6.890 3.189 6.012e-03 0.358 -2.124 RUNX1 runt-related transcription factor 1 21 -35115443, -35081967, -35081967 D43968 21q22.3 Hs.149261 Hs.612648 256

transcription factor activity

protein binding

ATP binding

nucleus

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

transcription activator activity

positive regulation of granulocyte differentiation

chloride ion binding

positive regulation of angiogenesis

positive regulation of transcription from RNA polymerase II promoter

Pathways in cancer

Chronic myeloid leukemia

Acute myeloid leukemia

227642_at 0.937 4.545 3.418 3.751e-03 0.317 -1.722 TFCP2L1 transcription factor CP2-like 1 2 -121690635 AI928242 2q14 Hs.156471 8

negative regulation of transcription from RNA polymerase II promoter

cell morphogenesis

epithelial cell maturation

transcription factor activity

transcription corepressor activity

nucleus

cytoplasm

steroid biosynthetic process

cytoplasm organization

salivary gland development

female pregnancy

determination of adult lifespan

membrane

general transcriptional repressor activity

regulation of transcription

positive regulation of growth

 
216627_s_at B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 9 -33100638 U10473 9p13 Hs.272011 41

Golgi trans cisterna

epithelial cell development

acute inflammatory response

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity

N-acetyllactosamine synthase activity

lactose synthase activity

extracellular region

Golgi apparatus

plasma membrane

carbohydrate metabolic process

lactose biosynthetic process

galactose metabolic process

protein amino acid terminal N-glycosylation

cell adhesion

binding of sperm to zona pellucida

penetration of zona pellucida

cytoskeletal protein binding

negative regulation of cell proliferation

glycoprotein biosynthetic process

oligosaccharide biosynthetic process

oligosaccharide biosynthetic process

external side of plasma membrane

integral to membrane

basolateral plasma membrane

transferase activity, transferring glycosyl groups

desmosome

glycocalyx

manganese ion binding

extracellular matrix organization

mammary gland development

brush border membrane

development of secondary sexual characteristics

metal ion binding

branching morphogenesis of a tube

leukocyte migration

regulation of cell motion

regulation of acrosome reaction

positive regulation of epithelial cell proliferation involved in wound healing

angiogenesis involved in wound healing

positive regulation of apoptosis involved in mammary gland involution

Galactose metabolism

N-Glycan biosynthesis

Keratan sulfate biosynthesis

Glycosphingolipid biosynthesis - lacto and neolacto series

Metabolic pathways

59697_at RAB15 RAB15, member RAS onocogene family 14 -64482284 AA582932 14q23.3 Hs.512492 11

nucleotide binding

GTP binding

plasma membrane

small GTPase mediated signal transduction

protein transport

 
206863_x_at -0.343 4.521 -2.379 3.084e-02 0.542 -3.505 HRK harakiri, BCL2 interacting protein (contains only BH3 domain) 12 -115783409 U76376 12q24.22 Hs.87247 18

protein binding

induction of apoptosis

negative regulation of survival gene product expression

regulation of apoptosis

 
219036_at 0.373 6.139 3.195 5.941e-03 0.357 -2.113 CEP70 centrosomal protein 70kDa 3 -139695876 NM_024491 3q22-q23 Hs.531962 9

protein binding

centrosome

 
212590_at 0.627 7.834 3.111 7.051e-03 0.372 -2.259 RRAS2 related RAS viral (r-ras) oncogene homolog 2 11 -14256041, -14256041 AI431643 11p15.2 Hs.502004 25

nucleotide binding

GTPase activity

protein binding

GTP binding

intracellular

endoplasmic reticulum

plasma membrane

Ras protein signal transduction

cellular process

positive regulation of cell migration

MAPK signaling pathway

Tight junction

Regulation of actin cytoskeleton

200837_at 0.393 8.040 2.746 1.487e-02 0.453 -2.892 BCAP31 B-cell receptor-associated protein 31 X -152619140, -152619140, -152619140, -152619140 NM_005745 Xq28 Hs.522817 35

Golgi membrane

receptor binding

endoplasmic reticulum

plasma membrane

integral to plasma membrane

intracellular protein transport

apoptosis

immune response

vesicle-mediated transport

 
211456_x_at 1.064 10.327 5.008 1.496e-04 0.171 0.982 MT1P2 metallothionein 1 pseudogene 2 1   AF333388 1q43 Hs.632513 1    
209207_s_at 0.512 6.153 3.450 3.509e-03 0.309 -1.665 SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) 1 143807763 BC001364 1q21.1 Hs.632438 Hs.715002 13

protein binding

endoplasmic reticulum

ER-Golgi intermediate compartment

Golgi apparatus

ER to Golgi vesicle-mediated transport

protein transport

membrane

integral to membrane

vesicle-mediated transport

melanosome

SNARE interactions in vesicular transport

214960_at 0.360 5.476 2.547 2.216e-02 0.499 -3.228 API5 apoptosis inhibitor 5 11 43290080 AF229253 11p11.2 Hs.435771 15

binding

nucleus

spliceosomal complex

cytoplasm

apoptosis

anti-apoptosis

anti-apoptosis

anti-apoptosis

fibroblast growth factor binding

 
221536_s_at LSG1 large subunit GTPase 1 homolog (S. cerevisiae) 3 -195842806 AL136897 3q29 Hs.518505 12

nucleotide binding

GTP binding

intracellular

nucleus

cytoplasm

endoplasmic reticulum

Cajal body

protein transport

hydrolase activity

nuclear export

 
237145_at 0.514 2.934 4.561 3.621e-04 0.183 0.252 EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 15 38013638 AI953362 15q15.1 Hs.656673 10

nucleotide binding

eukaryotic translation initiation factor 2alpha kinase activity

aminoacyl-tRNA ligase activity

protein binding

ATP binding

intracellular

cytoplasm

tRNA aminoacylation for protein translation

regulation of translational initiation

protein amino acid phosphorylation

transferase activity

cytosolic ribosome

 
219929_s_at ZFYVE21 zinc finger, FYVE domain containing 21 14 103251897 NM_024071 14q32.33 Hs.592322 4

zinc ion binding

metal ion binding

 
223028_s_at SNX9 sorting nexin 9 6 158164281 BC005022 6q25.1-q26 Hs.191213 24

protein binding

cell communication

protein transport

phosphoinositide binding

 
242738_s_at ZFHX3 zinc finger homeobox 3 16 -71374286 BG402859 16q22.3-q23.1 Hs.598297 26

negative regulation of transcription from RNA polymerase II promoter

RNA polymerase II transcription factor activity, enhancer binding

intracellular

nucleus

transcription factor complex

mitochondrion

regulation of transcription, DNA-dependent

zinc ion binding

transcription repressor activity

sequence-specific DNA binding

metal ion binding

 
213744_at 0.325 4.784 2.162 4.694e-02 0.583 -3.852 ATRNL1 attractin-like 1 10 116843113 AI817331 10q26 Hs.501127 3

binding

sugar binding

membrane

integral to membrane

 
201736_s_at 0.329 6.603 2.796 1.344e-02 0.437 -2.807 MARCH6 membrane-associated ring finger (C3HC4) 6 5 10406827 BF000409 5p15.2 Hs.432862 8

endoplasmic reticulum

zinc ion binding

membrane

integral to membrane

ligase activity

modification-dependent protein catabolic process

metal ion binding

 
1558486_at ZNF493 zinc finger protein 493 19 21371760, 21371760 BC022394 19p12 Hs.656558 3

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
215931_s_at 0.272 3.413 2.180 4.539e-02 0.581 -3.824 ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 20 46971681 AV657604 20q13.13 Hs.62578 23

Golgi membrane

ARF guanyl-nucleotide exchange factor activity

binding

intracellular

cytosol

exocytosis

intracellular signaling cascade

membrane

myosin binding

regulation of ARF protein signal transduction

 
212266_s_at 0.564 8.004 4.759 2.444e-04 0.172 0.578 SFRS5 splicing factor, arginine/serine-rich 5 14 69303581, 69303586 AW084582 14q24 Hs.632326 28

nucleotide binding

nuclear mRNA splicing, via spliceosome

RNA binding

protein binding

nucleus

mRNA splice site selection

RNA splicing

RS domain binding

 
214370_at 0.490 2.682 2.769 1.419e-02 0.446 -2.853 S100A8 S100 calcium binding protein A8 1 -151629131 AW238654 1q21 Hs.416073 91

calcium ion binding

protein binding

inflammatory response

 
228899_at 0.499 5.092 3.098 7.246e-03 0.375 -2.282 LOC100132884 hypothetical protein LOC100132884 7   AI870903 7q36.1 Hs.535040      
1554579_a_at MYO18B myosin XVIIIB 22 24468119 AB042648 22q11.2-q12.1 Hs.417959 11

nucleotide binding

motor activity

actin binding

protein binding

ATP binding

nucleus

cytoplasm

unconventional myosin complex

sarcomere

 
40255_at 0.351 6.337 3.428 3.669e-03 0.314 -1.703 DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 16 -66612674 AC004531 16q22.1 Hs.458313 9

nucleotide binding

RNA binding

helicase activity

ATP binding

nucleus

mitochondrion

ATP-dependent helicase activity

hydrolase activity

mitochondrial nucleoid

 
202815_s_at HEXIM1 hexamethylene bis-acetamide inducible 1 17 40580466 NM_006460 17q21.31 Hs.586945 Hs.634944 Hs.716487 28

negative regulation of transcription from RNA polymerase II promoter

cyclin-dependent protein kinase inhibitor activity

protein binding

nucleus

cytoplasm

heart development

specific transcriptional repressor activity

snRNA binding

regulation of transcription

negative regulation of cyclin-dependent protein kinase activity

 
1553585_a_at MAGEA5 melanoma antigen family A, 5 X -151033181 NM_021049 Xq28 Hs.668021 7

molecular_function

cellular_component

biological_process

 
225861_at C16orf14 chromosome 16 open reading frame 14 16 631849 AW001250 16p13.3 Hs.417710 5

protein binding

 
1564224_x_at -0.312 4.679 -2.653 1.791e-02 0.475 -3.049 UNQ2963 hypothetical LOC283314 12 7152179 AK091792 12p13.31 Hs.715709 2    
236846_at -0.549 3.810 -2.620 1.913e-02 0.489 -3.105 LOC284757 hypothetical protein LOC284757 20   AI808031 20q13.33 Hs.656468 1    
242565_x_at C21orf57 chromosome 21 open reading frame 57 21 46530694, 46530694 AI146751 21q22.3 Hs.474066 4

peptidase activity

metallopeptidase activity

zinc ion binding

metal ion binding

 
221235_s_at 0.243 6.044 2.473 2.565e-02 0.517 -3.351 LOC644617 hypothetical LOC644617 2   NM_030825 2q12.1 Hs.592796 1    
229292_at 0.288 4.599 2.700 1.630e-02 0.463 -2.970 EPB41L5 erythrocyte membrane protein band 4.1 like 5 2 120487138 AI652872 2q14.2 Hs.654802 5

binding

cytoplasm

cytoskeleton

adherens junction

cytoskeletal protein binding

extrinsic to membrane

cell junction

 
1553587_a_at 0.412 7.607 2.207 4.306e-02 0.577 -3.781 POLE4 polymerase (DNA-directed), epsilon 4 (p12 subunit) 2 75039282 NM_019896 2p12 Hs.469060 5

DNA-directed DNA polymerase activity

protein binding

intracellular

nucleus

transferase activity

nucleotidyltransferase activity

sequence-specific DNA binding

Purine metabolism

Pyrimidine metabolism

Metabolic pathways

DNA replication

Base excision repair

Nucleotide excision repair

225974_at 1.014 6.270 2.698 1.638e-02 0.464 -2.974 TMEM64 transmembrane protein 64 8 -91703398 BF732480 8q21.3 Hs.567759 2

membrane

integral to membrane

 
209717_at EVI5 ecotropic viral integration site 5 1 -92746840 AF008915 1p22.1 Hs.594434 11

Rab GTPase activator activity

protein binding

intracellular

nucleus

centrosome

cell cycle

multicellular organismal development

cell proliferation

regulation of Rab GTPase activity

cell division

 
214556_at -0.334 5.077 -2.579 2.077e-02 0.497 -3.174 SSTR4 somatostatin receptor 4 20 22964056 NM_001052 20p11.2 Hs.673846 29

receptor activity

G-protein coupled receptor activity

somatostatin receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein signaling, coupled to cyclic nucleotide second messenger

negative regulation of cell proliferation

Neuroactive ligand-receptor interaction

239218_at PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 7 -31795771 AI800515 7p14.3 Hs.655694 10

calmodulin-dependent cyclic-nucleotide phosphodiesterase activity

calmodulin binding

signal transduction

hydrolase activity

Purine metabolism

Calcium signaling pathway

Olfactory transduction

1553535_a_at 0.302 5.713 2.337 3.351e-02 0.552 -3.574 RANGAP1 Ran GTPase activating protein 1 22 -39971560 NM_002883 22q13 Hs.183800 34

condensed chromosome kinetochore

GTPase activator activity

Ran GTPase activator activity

protein binding

soluble fraction

nucleus

nuclear pore

cytoplasm

signal transduction

membrane

perinuclear region of cytoplasm

 
233353_at -0.239 4.397 -2.131 4.979e-02 0.591 -3.900 FER1L5 fer-1-like 5 (C. elegans) 2 96672300, 96724920 AL133022 2q11.2 Hs.534025 2

membrane

integral to membrane

 
239012_at 0.818 7.441 2.679 1.701e-02 0.469 -3.006 RNF144B ring finger protein 144B 6 18495572 R83905 6p22.3 Hs.148741 6

ubiquitin ligase complex

ubiquitin-protein ligase activity

protein binding

apoptosis

zinc ion binding

membrane

integral to membrane

ligase activity

modification-dependent protein catabolic process

protein ubiquitination during ubiquitin-dependent protein catabolic process

metal ion binding

 
209791_at 0.750 10.070 3.501 3.160e-03 0.304 -1.576 PADI2 peptidyl arginine deiminase, type II 1 -17265842 AL049569 1p36.13 Hs.33455 20

protein-arginine deiminase activity

calcium ion binding

cytoplasm

protein modification process

hydrolase activity

peptidyl-citrulline biosynthetic process from peptidyl-arginine

 
218678_at 1.166 7.924 3.477 3.318e-03 0.308 -1.618 NES nestin 1 -154905179 NM_024609 1q23.1 Hs.527971 87

structural molecule activity

cytoskeleton

intermediate filament

central nervous system development

 
1569129_s_at C3orf38 chromosome 3 open reading frame 38 3 88281582 BC016013 3p11.1 Hs.476944 Hs.518099 2

apoptosis

 
214771_x_at MPRIP myosin phosphatase Rho interacting protein 17 16886831, 16886831 AK025604 17p11.2 Hs.462341 16

actin binding

protein binding

cytoplasm

cytoskeleton

 
208072_s_at 0.368 8.209 2.237 4.069e-02 0.570 -3.734 DGKD diacylglycerol kinase, delta 130kDa 2 233927891, 233961538 NM_003648 2q37.1 Hs.471675 14

nucleotide binding

diacylglycerol kinase activity

ATP binding

cytoplasm

plasma membrane

epidermal growth factor receptor signaling pathway

activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway

multicellular organismal development

zinc ion binding

response to organic substance

cytoplasmic membrane-bounded vesicle

cell growth

transferase activity

second-messenger-mediated signaling

diacylglycerol binding

protein homodimerization activity

diacylglycerol metabolic process

metal ion binding

protein heterodimerization activity

protein homooligomerization

Glycerolipid metabolism

Glycerophospholipid metabolism

Metabolic pathways

Phosphatidylinositol signaling system

208743_s_at YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 20 42947757 BC001359 20q13.1 Hs.643544 109

cytoplasm

cytosol

protein targeting

Ras protein signal transduction

activation of pro-apoptotic gene products

enzyme binding

protein domain specific binding

negative regulation of protein amino acid dephosphorylation

melanosome

positive regulation of catalytic activity

perinuclear region of cytoplasm

Cell cycle

Neurotrophin signaling pathway

226673_at SH2D3C SH2 domain containing 3C 9 -129540416, -129540416, -129540416, -129540416, -129540416, -129540416 AW665063 9q34.11 Hs.306412 16

SH3/SH2 adaptor activity

guanyl-nucleotide exchange factor activity

protein binding

intracellular

cytoplasm

JNK cascade

small GTPase mediated signal transduction

membrane

 
210971_s_at ARNTL aryl hydrocarbon receptor nuclear translocator-like 11 13255900 AB000815 11p15 Hs.65734 37

transcription factor activity

signal transducer activity

nucleus

transcription factor complex

regulation of transcription, DNA-dependent

signal transduction

circadian rhythm

aryl hydrocarbon receptor binding

positive regulation of transcription from RNA polymerase II promoter

Hsp90 protein binding

Circadian rhythm - mammal

207382_at 0.772 8.137 3.692 2.131e-03 0.276 -1.241 TP63 tumor protein p63 3 190831909, 190831909, 190990142, 190990142 NM_003722 3q28 Hs.137569 238

response to tumor cell

transcription factor activity

nucleus

nucleus

cytoplasm

apoptosis

induction of apoptosis

multicellular organismal development

zinc ion binding

transcription activator activity

transcription activator activity

transcription repressor activity

negative regulation of cell growth

identical protein binding

positive regulation of Notch signaling pathway

negative regulation of transcription, DNA-dependent

positive regulation of transcription, DNA-dependent

metal ion binding

protein homotetramerization

 
241634_at -0.402 4.202 -3.045 8.073e-03 0.387 -2.374 LOC100132345 hypothetical LOC100132345 3   BE669595 3p24.3        
1569879_a_at -0.327 6.234 -3.608 2.534e-03 0.287 -1.388 MEGF11 multiple EGF-like-domains 11 15 -63974687 BC029999 15q22.31 Hs.712886 6

plasma membrane

integral to membrane

 
211197_s_at -0.288 5.329 -3.362 4.208e-03 0.325 -1.820 ICOSLG inducible T-cell co-stimulator ligand 21 -44471149 AL355690 21q22.3 Hs.14155 29

receptor binding

defense response

immune response

hyperosmotic response

signal transduction

membrane

integral to membrane

positive regulation of activated T cell proliferation

T cell activation

B cell activation

Cell adhesion molecules (CAMs)

225677_at BCAP29 B-cell receptor-associated protein 29 7 107007657, 107008439 AW152589 7q22-q31 Hs.303787 12

endoplasmic reticulum

intracellular protein transport

apoptosis

membrane

integral to membrane

vesicle-mediated transport

 
1569034_a_at -0.217 2.968 -2.386 3.047e-02 0.541 -3.495 LOC440864 hypothetical gene supported by BC040724 2   BC019620 2p16.3 Hs.388171 1    
212616_at CHD9 chromodomain helicase DNA binding protein 9 16 51646445 BF668950 16q12.2 Hs.59159 Hs.622347 10

nucleotide binding

chromatin

DNA binding

chromatin binding

helicase activity

protein binding

ATP binding

nucleus

cytoplasm

chromatin assembly or disassembly

chromatin modification

hydrolase activity

regulation of transcription

 
235033_at NPEPL1 aminopeptidase-like 1 20 56701267 AL577823 20q13.32 Hs.554211 Hs.654868 7

aminopeptidase activity

intracellular

proteolysis

peptidase activity

zinc ion binding

manganese ion binding

metal ion binding

 
224445_s_at ZFYVE21 zinc finger, FYVE domain containing 21 14 103251897 BC005999 14q32.33 Hs.592322 4

zinc ion binding

metal ion binding

 
220944_at PGLYRP4 peptidoglycan recognition protein 4 1 -151569220 NM_020393 1q21 Hs.58356 5

protein binding

intracellular

N-acetylmuramoyl-L-alanine amidase activity

peptidoglycan catabolic process

peptidoglycan receptor activity

membrane

detection of bacterium

innate immune response

defense response to Gram-positive bacterium

 
226678_at UNC13D unc-13 homolog D (C. elegans) 17 -71334901 BG054744 17q25.1 Hs.41045 21

granuloma formation

germinal center formation

cytoplasm

exocytosis

phagocytosis

membrane

natural killer cell degranulation

defense response to virus

 
205113_at 0.731 2.959 3.871 1.474e-03 0.250 -0.928 NEFM neurofilament, medium polypeptide 8 24827178, 24828359 NM_005382 8p21 Hs.458657 Hs.615287 24

microtubule cytoskeleton organization

structural constituent of cytoskeleton

cytoskeleton

neurofilament

axon cargo transport

axon

regulation of axon diameter

neuromuscular junction

intermediate filament bundle assembly

neurofilament cytoskeleton organization

Amyotrophic lateral sclerosis (ALS)

222633_at 0.394 8.550 3.499 3.173e-03 0.305 -1.580 TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 3 -178221235 AF268193 3q26.32 Hs.715537 14

nucleus

chromatin modification

modification-dependent protein catabolic process

regulation of transcription

Wnt signaling pathway

204723_at 1.046 5.615 3.216 5.687e-03 0.356 -2.076 SCN3B sodium channel, voltage-gated, type III, beta 11 -123005104 AB032984 11q23.3 Hs.4865 19

voltage-gated ion channel activity

voltage-gated sodium channel activity

plasma membrane

ion transport

sodium ion transport

integral to membrane

sodium ion binding

 
210206_s_at DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) 12 31118045 U33833 12p11 Hs.443960 13

mitotic sister chromatid segregation

S phase of mitotic cell cycle

G2/M transition of mitotic cell cycle

nucleotide binding

DNA binding

RNA binding

ATP-dependent DNA helicase activity

ATP binding

nucleus

nucleolus

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

cell cycle

positive regulation of cell proliferation

hydrolase activity

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

 
237252_at THBD thrombomodulin 20 -22974269 AW119113 20p11.2 Hs.2030 133

transmembrane receptor activity

calcium ion binding

protein binding

extracellular space

plasma membrane

plasma membrane

integral to plasma membrane

female pregnancy

blood coagulation

embryonic development

response to X-ray

response to lipopolysaccharide

response to cAMP

Complement and coagulation cascades

216841_s_at SOD2 superoxide dismutase 2, mitochondrial 6 -160022744, -160020138 X15132 6q25.3 Hs.487046 354

response to superoxide

age-dependent response to oxidative stress

age-dependent response to reactive oxygen species

release of cytochrome c from mitochondria

liver development

detection of oxygen

vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure

superoxide dismutase activity

protein binding

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

double-strand break repair

regulation of transcription from RNA polymerase II promoter

glutathione metabolic process

mitochondrion organization

heart development

locomotory behavior

regulation of blood pressure

post-embryonic development

organ senescence

response to gamma radiation

response to activity

oxidoreductase activity

removal of superoxide radicals

respiratory electron transport chain

hemopoiesis

manganese ion binding

oxygen homeostasis

response to hydrogen peroxide

superoxide anion generation

negative regulation of neuron apoptosis

positive regulation of nitric oxide biosynthetic process

negative regulation of fat cell differentiation

metal ion binding

negative regulation of fibroblast proliferation

neuron development

response to axon injury

erythrophore differentiation

regulation of catalytic activity

protein homotetramerization

regulation of mitochondrial membrane potential

iron ion homeostasis

response to hyperoxia

oxidation reduction

Huntington's disease

211744_s_at CD58 CD58 molecule 1 -116862845, -116858679 BC005930 1p13 Hs.34341 38

protein binding

plasma membrane

integral to plasma membrane

cell-cell adhesion

anchored to membrane

Cell adhesion molecules (CAMs)

217817_at 0.340 7.266 3.927 1.313e-03 0.243 -0.831 ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 3 9809226 BE891920 3p25.3 Hs.323342 16

cytoplasm

cytoskeleton

Arp2/3 protein complex

actin filament polymerization

protein binding, bridging

cell projection

actin nucleation

actin filament binding

Fc gamma R-mediated phagocytosis

Regulation of actin cytoskeleton

204759_at 0.703 6.766 2.891 1.106e-02 0.425 -2.642 RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 13 -47961099 NM_001268 13q14.3 Hs.657385 8

Ran guanyl-nucleotide exchange factor activity

protein binding

 
221207_s_at -0.417 6.864 -2.488 2.489e-02 0.513 -3.326 NBEA neurobeachin 13 34414455 NM_015678 13q13 Hs.491172 11

protein binding

cytoplasm

trans-Golgi network

cytosol

plasma membrane

protein localization

endomembrane system

protein kinase binding

 
238889_at 0.411 2.954 3.506 3.125e-03 0.304 -1.567 AGBL5 ATP/GTP binding protein-like 5 2 27127994, 27127994 AA045527 2p23.3 Hs.138207 4

metallocarboxypeptidase activity

nucleus

cytoplasm

proteolysis

zinc ion binding

 
202606_s_at 0.380 7.210 2.854 1.194e-02 0.426 -2.706 TLK1 tousled-like kinase 1 2 -171555578, -171555578, -171555578 NM_012290 2q31.1 Hs.719163 23

nucleotide binding

regulation of chromatin assembly or disassembly

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

protein amino acid phosphorylation

intracellular protein transport

response to DNA damage stimulus

cell cycle

intracellular signaling cascade

chromatin modification

transferase activity

 
211549_s_at 0.468 3.008 4.075 9.691e-04 0.223 -0.574 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 4 -175647902, -175647902 U63296 4q34-q35 Hs.596913 47

prostaglandin E receptor activity

binding

nucleus

nucleolus

cytoplasm

cytosol

lipid metabolic process

fatty acid metabolic process

prostaglandin metabolic process

transforming growth factor beta receptor signaling pathway

female pregnancy

parturition

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

oxidoreductase activity

lipoxygenase pathway

protein homodimerization activity

negative regulation of cell cycle

NAD or NADH binding

oxidation reduction

 
214792_x_at -0.534 5.584 -3.400 3.892e-03 0.319 -1.753 VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 17 -8003189 AI955119 17p13.1 Hs.25348 66

protein binding

integral to plasma membrane

membrane

vesicle-mediated transport

synaptosome

cell junction

cytoplasmic vesicle

synapse

SNARE interactions in vesicular transport

224739_at -0.481 7.857 -2.272 3.799e-02 0.565 -3.678 PIM3 pim-3 oncogene 22 48740146 BE778706 22q13 Hs.530381 10

nucleotide binding

protein serine/threonine kinase activity

ATP binding

protein amino acid phosphorylation

transferase activity

 
228930_at 0.445 6.512 2.443 2.725e-02 0.526 -3.401 SCARNA15 small Cajal body-specific RNA 15 15 81221750 AI679611 15q25.2 Hs.513091 1    
223538_at 0.419 7.560 2.147 4.828e-02 0.589 -3.875 SERF1A small EDRK-rich factor 1A (telomeric) 5 69356827, 69356827, 70232245, 70232245, -510079, -499652 AF073518 5q12.2-q13.3 Hs.559428 7    
233314_at PTEN phosphatase and tensin homolog 10 89613174 AK021487 10q23.3 Hs.500466 557

regulation of cyclin-dependent protein kinase activity

magnesium ion binding

angiogenesis

phosphatidylinositol-3-phosphatase activity

protein serine/threonine phosphatase activity

protein tyrosine phosphatase activity

platelet-derived growth factor receptor binding

protein binding

nucleus

cytoplasm

cytoplasm

cytosol

protein amino acid dephosphorylation

protein amino acid dephosphorylation

lipid metabolic process

induction of apoptosis

central nervous system development

protein tyrosine/serine/threonine phosphatase activity

negative regulation of cell proliferation

lipid binding

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

hydrolase activity

PDZ domain binding

negative regulation of cell migration

neuron projection development

regulation of protein stability

negative regulation of apoptosis

endothelial cell migration

inositol phosphate dephosphorylation

phosphoinositide dephosphorylation

platelet-derived growth factor receptor signaling pathway

cardiac muscle tissue development

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

negative regulation of focal adhesion formation

negative regulation of protein kinase B signaling cascade

Inositol phosphate metabolism

Phosphatidylinositol signaling system

p53 signaling pathway

Focal adhesion

Tight junction

Pathways in cancer

Endometrial cancer

Glioma

Prostate cancer

Melanoma

Small cell lung cancer

201796_s_at VARS valyl-tRNA synthetase 6 -31853275, -3191374, -3006978 BE790854 6p21.3 Hs.520026 15

nucleotide binding

valine-tRNA ligase activity

protein binding

ATP binding

intracellular

cytoplasm

mitochondrion

cytosol

translational elongation

valyl-tRNA aminoacylation

defense response

response to unfolded protein

response to nutrient

ligase activity

protein complex

NF-kappaB binding

Valine, leucine and isoleucine biosynthesis

Aminoacyl-tRNA biosynthesis

232395_x_at 0.465 2.682 4.039 1.043e-03 0.225 -0.636 AGBL3 ATP/GTP binding protein-like 3 7 134321798 AI674787 7q33 Hs.648616 4

metallocarboxypeptidase activity

cytoplasm

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

metal ion binding

 
223466_x_at COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 5 -74702683, -74702683 BC000102 5q13.3 Hs.270437 26

protein kinase activity

protein binding

cellular_component

cytoplasm

endoplasmic reticulum

Golgi apparatus

protein amino acid phosphorylation

lipid transport

immune response

 
1564063_a_at -0.376 5.207 -3.741 1.924e-03 0.273 -1.154 ATP11B ATPase, class VI, type 11B 3 183993984 AK093727 3q27 Hs.478429 8

nucleotide binding

magnesium ion binding

phospholipid-translocating ATPase activity

ATP binding

nuclear inner membrane

ATP biosynthetic process

ion transport

metabolic process

ion transmembrane transporter activity

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

phospholipid transport

aminophospholipid transport

membrane

integral to membrane

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

 
212667_at 0.604 9.178 3.151 6.500e-03 0.364 -2.190 SPARC secreted protein, acidic, cysteine-rich (osteonectin) 5 -151021201 AL575922 5q31.3-q32 Hs.111779 Hs.708558 115

ossification

copper ion binding

calcium ion binding

collagen binding

extracellular region

extracellular region

basement membrane

signal transduction

platelet alpha granule lumen

regulation of cell proliferation

extracellular matrix binding

 
218077_s_at 0.353 5.205 2.374 3.118e-02 0.543 -3.514 ZDHHC3 zinc finger, DHHC-type containing 3 3 -44931757 BE542551 3p21.31 Hs.61430 8

Golgi apparatus

zinc ion binding

acyltransferase activity

membrane

integral to membrane

transferase activity

metal ion binding

 
218906_x_at KLC2 kinesin light chain 2 11 65781340, 65781666, 65781749, 65781749 NM_022822 11q13.2 Hs.280792 22

microtubule motor activity

protein binding

cytosol

kinesin complex

microtubule

protein complex

 
1560974_s_at NOS1 nitric oxide synthase 1 (neuronal) 12 -116135361 BF447723 12q24.2-q24.31 Hs.654410 188

response to hypoxia

photoreceptor inner segment

nitric-oxide synthase activity

calmodulin binding

cytoplasm

cytoskeleton

arginine catabolic process

nitric oxide biosynthetic process

myoblast fusion

electron carrier activity

response to heat

FMN binding

negative regulation of calcium ion transport into cytosol

oxidoreductase activity

sarcoplasmic reticulum

heme binding

multicellular organismal response to stress

tetrahydrobiopterin binding

arginine binding

neurotransmitter biosynthetic process

sarcolemma

cell projection

dendritic spine

positive regulation of vasodilation

positive regulation of vasodilation

cadmium ion binding

metal ion binding

perinuclear region of cytoplasm

FAD binding

NADP or NADPH binding

oxidation reduction

regulation of cardiac muscle contraction

Arginine and proline metabolism

Metabolic pathways

Calcium signaling pathway

Long-term depression

Alzheimer's disease

Amyotrophic lateral sclerosis (ALS)

Pathways in cancer

Small cell lung cancer

201245_s_at 0.382 7.079 2.852 1.199e-02 0.426 -2.710 OTUB1 OTU domain, ubiquitin aldehyde binding 1 11 63509900 AL523776 11q13.1 Hs.473788 15

immune response

peptidase activity

cysteine-type peptidase activity

modification-dependent protein catabolic process

 
223294_at 0.352 7.370 2.209 4.289e-02 0.576 -3.778 CXorf26 chromosome X open reading frame 26 X 75309172 BC001220 Xq13.3 Hs.370100 6

molecular_function

cellular_component

biological_process

 
213875_x_at 0.446 6.283 2.515 2.362e-02 0.508 -3.282 C6orf62 chromosome 6 open reading frame 62 6 -24813069 BG252842 6p22.3 Hs.519930 6

molecular_function

cellular_component

intracellular

biological_process

 
1552651_a_at 0.413 3.771 3.477 3.316e-03 0.308 -1.617 RFFL ring finger and FYVE-like domain containing 1 17 -30360243, -30360243 AK093112 17q12 Hs.13680 11

protein binding

cytoplasm

intracellular protein transport

apoptosis

zinc ion binding

membrane

cytoplasmic membrane-bounded vesicle

ligase activity

modification-dependent protein catabolic process

metal ion binding

 
201573_s_at ETF1 eukaryotic translation termination factor 1 5 -137869682 M75715 5q31.1 Hs.483494 32

RNA binding

protein binding

cytoplasm

regulation of translational termination

protein amino acid methylation

translation release factor activity, codon specific

ribosome binding

 
204394_at SLC43A1 solute carrier family 43, member 1 11 -57008582 NM_003627 11p11.2-p11.1 Hs.591952 8

integral to plasma membrane

transport

neutral amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity

neutral amino acid transport

L-amino acid transport

membrane

 
232355_at SNORD114-3 small nucleolar RNA, C/D box 114-3 14 100489438 AU146318 14q32 Hs.613596 2    
216779_at -0.173 3.685 -2.327 3.417e-02 0.553 -3.590 CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 X 83002825 Z22780 Xq21.1 Hs.444230 6

structural molecule activity

cytoplasm

cytoskeleton

multicellular organismal development

spermatogenesis

cell differentiation

cytoskeletal calyx

acrosomal matrix

 
228375_at 1.315 5.406 4.604 3.321e-04 0.179 0.324 IGSF11 immunoglobulin superfamily, member 11 3 -120102168, -120102168 BE221674 3q13.32 Hs.112873 7

receptor activity

protein binding

plasma membrane

cell adhesion

integral to membrane

regulation of growth

 
224454_at ETNK1 ethanolamine kinase 1 12 22669342, 22669342 BC006111 12p12.1 Hs.29464 4

nucleotide binding

ethanolamine kinase activity

ATP binding

cytoplasm

phosphatidylethanolamine biosynthetic process

transferase activity

Glycerophospholipid metabolism

Metabolic pathways

202638_s_at ICAM1 intercellular adhesion molecule 1 19 10242516 NM_000201 19p13.3-p13.2 Hs.643447 541

immunological synapse

regulation of leukocyte mediated cytotoxicity

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell antigen processing and presentation

positive regulation of cellular extravasation

transmembrane receptor activity

integrin binding

protein binding

extracellular space

cytoplasm

plasma membrane

plasma membrane

integral to plasma membrane

heterophilic cell adhesion

leukocyte adhesion

external side of plasma membrane

membrane to membrane docking

regulation of cell adhesion

cell adhesion mediated by integrin

interspecies interaction between organisms

virion attachment, binding of host cell surface receptor

leukocyte migration

adhesion to symbiont

Cell adhesion molecules (CAMs)

Natural killer cell mediated cytotoxicity

Leukocyte transendothelial migration

235104_at 0.714 4.216 3.158 6.402e-03 0.364 -2.177 ERAP2 endoplasmic reticulum aminopeptidase 2 5 96237399 BG292389 5q15 Hs.482910 14

aminopeptidase activity

endoplasmic reticulum

endoplasmic reticulum lumen

proteolysis

immune response

regulation of blood pressure

peptidase activity

metallopeptidase activity

zinc ion binding

membrane

integral to membrane

antigen processing and presentation of endogenous peptide antigen via MHC class I

metal ion binding

 
228403_at -0.268 5.692 -2.235 4.084e-02 0.570 -3.737 ENHO energy homeostasis associated 9 -34511039 AL541276 9p13.3 Hs.522085 3

extracellular region

 
219269_at -1.917 6.784 -4.524 3.898e-04 0.192 0.190 HMBOX1 homeobox containing 1 8 28803829, 28804143 NM_024567 8p21.1 Hs.591836 5

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

sequence-specific DNA binding

 
212197_x_at 0.289 8.775 2.447 2.699e-02 0.525 -3.393 MPRIP myosin phosphatase Rho interacting protein 17 16886831, 16886831 AB020671 17p11.2 Hs.462341 16

actin binding

protein binding

cytoplasm

cytoskeleton

 
202122_s_at PLIN3 perilipin 3 19 -4789345 NM_005817 19p13.3 Hs.140452 35

protein binding

cytoplasm

endosome

Golgi apparatus

lipid particle

membrane

vesicle-mediated transport

 
226342_at SPTBN1 spectrin, beta, non-erythrocytic 1 2 54536957, 54639034 AW593244 2p21 Hs.503178 Hs.705692 46

actin binding

structural constituent of cytoskeleton

calmodulin binding

nucleus

nucleolus

cytoplasm

plasma membrane

common-partner SMAD protein phosphorylation

SMAD protein nuclear translocation

spectrin

cortical cytoskeleton

M band

actin filament capping

 
205289_at BMP2 bone morphogenetic protein 2 20 6696744 AA583044 20p12 Hs.73853 195

branching involved in ureteric bud morphogenesis

cytokine activity

extracellular region

extracellular region

extracellular space

inflammatory response

cell-cell signaling

growth factor activity

negative regulation of cell proliferation

embryonic development

organ morphogenesis

positive regulation of pathway-restricted SMAD protein phosphorylation

specific transcriptional repressor activity

positive regulation of bone mineralization

BMP signaling pathway

BMP signaling pathway

negative regulation of gene-specific transcription

cardiac cell differentiation

growth

odontogenesis of dentine-containing tooth

cell fate commitment

positive regulation of osteoblast differentiation

negative regulation of cell cycle

positive regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

SMAD binding

positive regulation of astrocyte differentiation

cartilage development

cardiac epithelial to mesenchymal transition

Cytokine-cytokine receptor interaction

Hedgehog signaling pathway

TGF-beta signaling pathway

Pathways in cancer

Basal cell carcinoma

1554631_at -0.288 5.793 -2.759 1.448e-02 0.447 -2.869 ATM ataxia telangiectasia mutated 11 107598768, 107663328 BC007023 11q22-q23 Hs.367437 504

nucleotide binding

DNA binding

protein serine/threonine kinase activity

ATP binding

nucleus

nucleoplasm

DNA repair

response to DNA damage stimulus

cell cycle

mitotic cell cycle spindle assembly checkpoint

reciprocal meiotic recombination

signal transduction

cell death

response to ionizing radiation

1-phosphatidylinositol-3-kinase activity

transferase activity

cytoplasmic vesicle

protein N-terminus binding

Cell cycle

p53 signaling pathway

Apoptosis

208741_at SAP18 Sin3A-associated protein, 18kDa 13 20612652 AW274856 13q12.11 Hs.524899 17

histone deacetylase complex

transcription corepressor activity

protein binding

nucleus

cytoplasm

regulation of transcription from RNA polymerase II promoter

regulation of transcription

 
228941_at ALG10B asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast) 12 36996823 AW295395 12q12 Hs.259305 5

plasma membrane

integral to membrane

transferase activity, transferring hexosyl groups

N-Glycan biosynthesis

Metabolic pathways

218368_s_at 0.873 7.033 3.102 7.193e-03 0.374 -2.276 TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 16 3010313 NM_016639 16p13.3 Hs.355899 25

angiogenesis

ruffle

receptor activity

protein binding

plasma membrane

apoptosis

cell motion

substrate-bound cell migration, cell attachment to substrate

cell adhesion

multicellular organismal development

cell death

cell surface

integral to membrane

cell differentiation

positive regulation of axon extension

Cytokine-cytokine receptor interaction

1564029_at -0.368 2.763 -3.700 2.092e-03 0.276 -1.226 USP49 ubiquitin specific peptidase 49 6 -41873360 AL049937 6p21 Hs.665742 5

ubiquitin thiolesterase activity

ubiquitin-dependent protein catabolic process

peptidase activity

cysteine-type peptidase activity

zinc ion binding

metal ion binding

 
212882_at KLHL18 kelch-like 18 (Drosophila) 3 47299333 AB018338 3p21.31 Hs.517946 8

protein binding

 
221905_at CYLD cylindromatosis (turban tumor syndrome) 16 49333461, 49333529 BF516433 16q12.1 Hs.578973 54

structural constituent of ribosome

ubiquitin thiolesterase activity

intracellular

cytoplasm

ribosome

cytoskeleton

translation

ubiquitin-dependent protein catabolic process

cell cycle

peptidase activity

cysteine-type peptidase activity

perinuclear region of cytoplasm

RIG-I-like receptor signaling pathway

1553447_at AGBL1 ATP/GTP binding protein-like 1 15 84486245 NM_152336 15q25.3 Hs.679833 5

metallocarboxypeptidase activity

binding

cytoplasm

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

metal ion binding

 
228126_x_at -0.218 4.605 -2.375 3.111e-02 0.543 -3.512 CTXN1 cortexin 1 19 -7895380 BF982289 19p13.2 Hs.657978 3

membrane

integral to membrane

 
238738_at PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 16 72888181 AW361702 16q23-q24 Hs.440604 47

proteasome complex

protein binding

cytosol

proteasome regulatory particle

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

224088_at NMUR2 neuromedin U receptor 2 5 -151751294 AF272363 5q33.1 Hs.283093 10

neuromedin U receptor activity

reduction of food intake in response to dietary excess

receptor activity

G-protein coupled receptor activity

intracellular calcium activated chloride channel activity

GTP binding

plasma membrane

calcium ion transport

regulation of smooth muscle contraction

signal transduction

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

elevation of cytosolic calcium ion concentration

neuropeptide signaling pathway

cell-cell signaling

central nervous system development

grooming behavior

feeding behavior

integral to membrane

transmission of nerve impulse

activation of phospholipase A2 activity by calcium-mediated signaling

inositol phosphate-mediated signaling

response to pain

arachidonic acid secretion

response to protein stimulus

Neuroactive ligand-receptor interaction

220610_s_at LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 3 -37069120 NM_006309 3p22.2 Hs.719246 7

protein binding

cellular_component

biological_process

Wnt receptor signaling pathway

LRR domain binding

 
222443_s_at 0.547 7.690 3.838 1.576e-03 0.257 -0.985 RBM8A RNA binding motif protein 8A 1 144218994 AF182415 1q12 Hs.356873 43

nucleotide binding

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nuclear mRNA splicing, via spliceosome

mRNA binding

protein binding

nucleus

spliceosomal complex

cytoplasm

transport

biological_process

RNA splicing

nuclear speck

exon-exon junction complex

mRNA transport

 
214853_s_at 0.325 8.396 3.113 7.033e-03 0.372 -2.257 SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1 -153201397, -153201397 AI091079 1q21 Hs.433795 255

activation of MAPK activity

transmembrane receptor protein tyrosine kinase adaptor protein activity

epidermal growth factor receptor binding

insulin receptor binding

insulin-like growth factor receptor binding

protein binding

phospholipid binding

cytoplasm

mitochondrion

cytosol

plasma membrane

epidermal growth factor receptor signaling pathway

regulation of epidermal growth factor receptor activity

intracellular signaling cascade

Ras protein signal transduction

positive regulation of cell proliferation

insulin receptor signaling pathway

regulation of growth

positive regulation of DNA replication

Shc-EGFR complex

ErbB signaling pathway

Chemokine signaling pathway

Focal adhesion

Natural killer cell mediated cytotoxicity

Neurotrophin signaling pathway

Insulin signaling pathway

Glioma

Chronic myeloid leukemia

227702_at CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 1 47261826 AA557324 1p33 Hs.439760 7

monooxygenase activity

endoplasmic reticulum

microsome

electron carrier activity

membrane

heme binding

metal ion binding

oxidation reduction

aromatase activity

 
230700_at RTN4RL1 reticulon 4 receptor-like 1 17 -1784720 H06251 17p13.3 Hs.22917 5

receptor activity

protein binding

plasma membrane

axon regeneration

anchored to plasma membrane

 
205503_at PTPN14 protein tyrosine phosphatase, non-receptor type 14 1 -212597633 NM_005401 1q32.2 Hs.696573 13

protein tyrosine phosphatase activity

binding

cytoplasm

cytoskeleton

protein amino acid dephosphorylation

hydrolase activity

 
214636_at 1.922 2.674 3.123 6.888e-03 0.370 -2.239 CALCB calcitonin-related polypeptide beta 11 15051721 AA747379 11p15.2-p15.1 Hs.534305 15

neuropeptide hormone activity

extracellular region

soluble fraction

cellular calcium ion homeostasis

signal transduction

vasodilation

 
1555870_at RNF207 ring finger protein 207 1 6188775 AK056658 1p36.31 Hs.716549 7

protein binding

intracellular

zinc ion binding

metal ion binding

 
204647_at 0.684 8.045 2.436 2.757e-02 0.526 -3.411 HOMER3 homer homolog 3 (Drosophila) 19 -18901009, -18901009, -18901009, -18901009, -18901009 NM_004838 19p13.11 Hs.10326 16

protein binding

cytoplasm

plasma membrane

protein targeting

metabotropic glutamate receptor signaling pathway

postsynaptic density

cell junction

synapse

postsynaptic membrane

 
225341_at 0.549 6.223 3.631 2.416e-03 0.284 -1.348 MTERFD3 MTERF domain containing 3 12 -105895198 BF697312 12q24.1 Hs.5009 6

mitochondrion

transcription termination

regulation of transcription

 
223698_at SLC25A36 solute carrier family 25, member 36 3 142143351 AL136803 3q23 Hs.144130 7

transporter activity

binding

mitochondrion

mitochondrial inner membrane

transport

membrane

integral to membrane

response to estradiol stimulus

 
226360_at ZNRF3 zinc and ring finger 3 22 27609889 AK022809 22q12.1 Hs.655242 8

protein binding

zinc ion binding

membrane

integral to membrane

metal ion binding

 
1564658_at C7orf52 chromosome 7 open reading frame 52 7 -100600497 BC037583 7q22.1 Hs.213044 2

N-acetyltransferase activity

metabolic process

acyltransferase activity

transferase activity

 
210764_s_at 1.706 5.000 3.236 5.453e-03 0.352 -2.041 CYR61 cysteine-rich, angiogenic inducer, 61 1 85819031 AF003114 1p31-p22 Hs.8867 82

regulation of cell growth

patterning of blood vessels

insulin-like growth factor binding

extracellular region

chemotaxis

cell adhesion

heparin binding

cell proliferation

anatomical structure morphogenesis

positive regulation of cell-substrate adhesion

extracellular matrix organization

extracellular matrix binding

 
210896_s_at 0.542 5.196 3.535 2.945e-03 0.298 -1.516 ASPH aspartate beta-hydroxylase 8 -62739837, -62699648, -62699648, -62575669 AF306765 8q12.1 Hs.591874 24

peptide-aspartate beta-dioxygenase activity

binding

iron ion binding

calcium ion binding

endoplasmic reticulum

endoplasmic reticulum membrane

muscle contraction

pattern specification process

negative regulation of cell proliferation

structural constituent of muscle

electron carrier activity

membrane

integral to membrane

oxidoreductase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

peptidyl-amino acid modification

integral to endoplasmic reticulum membrane

limb morphogenesis

peptidyl-aspartic acid hydroxylation

oxidation reduction

palate development

face morphogenesis

 
215826_x_at ZNF835 zinc finger protein 835 19 -61866764 AK023017 19q13.43 Hs.458438 1

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
228178_s_at CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 16 -67709413, -67709413 AI739514 16q22.1 Hs.85962 9

DNA binding

nucleus

DNA replication

cell cycle

 
208866_at CSNK1A1 casein kinase 1, alpha 1 5 -148855037 BF510713 5q32 Hs.529862 Hs.712555 53

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

cytosol

protein amino acid phosphorylation

Wnt receptor signaling pathway

transferase activity

Wnt signaling pathway

Hedgehog signaling pathway

235463_s_at LASS6 LAG1 homolog, ceramide synthase 6 2 169021080 AI081356 2q24.3 Hs.506829 Hs.718403 5

transcription factor activity

nucleus

endoplasmic reticulum

regulation of transcription, DNA-dependent

lipid biosynthetic process

membrane

integral to membrane

sphingolipid biosynthetic process

sequence-specific DNA binding

ceramide biosynthetic process

sphingosine N-acyltransferase activity

 
239084_at SNAP29 synaptosomal-associated protein, 29kDa 22 19543291 BE896490 22q11.21 Hs.108002 Hs.701035 19

SNAP receptor activity

cytoplasm

plasma membrane

exocytosis

vesicle targeting

membrane fusion

protein transport

synaptosome

cell junction

synapse

SNARE interactions in vesicular transport

1552610_a_at JAK1 Janus kinase 1 1 -65071493 NM_002227 1p32.3-p31.3 Hs.207538 118

nucleotide binding

non-membrane spanning protein tyrosine kinase activity

Janus kinase activity

growth hormone receptor binding

protein binding

ATP binding

nucleus

cytoplasm

cytoskeleton

enzyme linked receptor protein signaling pathway

protein kinase cascade

membrane

transferase activity

peptidyl-tyrosine phosphorylation

cytokine-mediated signaling pathway

response to antibiotic

Jak-STAT signaling pathway

Pathways in cancer

Pancreatic cancer

212567_s_at MAP4 microtubule-associated protein 4 3 -47989573, -47867183, -47867183 AL523310 3p21 Hs.517949 40

structural molecule activity

protein binding

microtubule

microtubule associated complex

negative regulation of microtubule depolymerization

 
210540_s_at 0.493 3.874 2.567 2.129e-02 0.497 -3.195 B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 3 -120413278 BC004523 3q13.3 Hs.13225 14

N-acetyllactosamine synthase activity

Golgi apparatus

carbohydrate metabolic process

membrane lipid metabolic process

galactosyltransferase activity

membrane

integral to membrane

transferase activity, transferring glycosyl groups

manganese ion binding

metal ion binding

Keratan sulfate biosynthesis

Glycosphingolipid biosynthesis - lacto and neolacto series

Metabolic pathways

232636_at 1.981 4.987 3.038 8.194e-03 0.387 -2.387 SLITRK4 SLIT and NTRK-like family, member 4 X -142543607 AL080239 Xq27.3 Hs.272284 4

protein binding

axonogenesis

membrane

integral to membrane

 
209226_s_at 0.353 7.806 3.137 6.684e-03 0.367 -2.214 TNPO1 transportin 1 5 72148173, 72179685 U72069 5q13.2 Hs.482497 58

protein import into nucleus, docking

protein import into nucleus, translocation

protein binding

nucleus

nuclear pore

cytoplasm

nuclear localization sequence binding

protein transporter activity

interspecies interaction between organisms

 
215265_at EMX1 empty spiracles homeobox 1 2 72998111 BF515060 2p14-p13 Hs.516090 9

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

brain development

post-embryonic development

cerebral cortex development

neuron differentiation

response to drug

sequence-specific DNA binding

 
208322_s_at 0.480 7.144 3.258 5.218e-03 0.348 -2.003 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 8 -134536272 NM_003033 8q24.22 Hs.374257 20

beta-galactoside alpha-2,3-sialyltransferase activity

extracellular region

Golgi apparatus

protein amino acid glycosylation

membrane

integral to membrane

integral to Golgi membrane

O-Glycan biosynthesis

Keratan sulfate biosynthesis

Glycosphingolipid biosynthesis - globo series

Glycosphingolipid biosynthesis - ganglio series

Metabolic pathways

236657_at LOC100130506 hypothetical protein LOC100130506 2   AW014647          
207005_s_at BCL2 B-cell CLL/lymphoma 2 18 -59136166, -58941558 NM_000657 18q21.3 18q21.33 Hs.150749 705

G1/S transition of mitotic cell cycle

protein phosphatase type 2A complex

cell morphogenesis

response to acid

ovarian follicle development

ureteric bud development

branching involved in ureteric bud morphogenesis

behavioral fear response

response to hypoxia

B cell homeostasis

release of cytochrome c from mitochondria

regulation of cell-matrix adhesion

protease binding

lymphoid progenitor cell differentiation

B cell lineage commitment

T cell lineage commitment

immune system development

renal system process

intracellular

membrane fraction

nucleus

cytoplasm

mitochondrion

mitochondrial outer membrane

mitochondrial outer membrane

mitochondrial outer membrane

endoplasmic reticulum

endoplasmic reticulum membrane

microsome

cytosol

calcineurin complex

protein amino acid dephosphorylation

melanin metabolic process

oxygen and reactive oxygen species metabolic process

regulation of nitrogen utilization

anti-apoptosis

humoral immune response

response to oxidative stress

actin filament organization

female pregnancy

cell aging

response to nutrient

transcription factor binding

cell death

positive regulation of cell proliferation

male gonad development

activation of pro-apoptotic gene products

response to radiation

response to heat

response to external stimulus

response to toxin

post-embryonic development

organ morphogenesis

response to inorganic substance

response to iron ion

response to UV-B

response to gamma radiation

regulation of gene expression

negative regulation of calcium ion transport into cytosol

regulation of glycoprotein biosynthetic process

mesenchymal cell development

positive regulation of neuron maturation

positive regulation of smooth muscle cell migration

membrane

integral to membrane

cell-cell adhesion

transcription activator activity

peptidyl-threonine phosphorylation

cochlear nucleus development

gland morphogenesis

hemopoiesis

negative regulation of ossification

negative regulation of cell growth

negative regulation of cell migration

response to caffeine

hair follicle morphogenesis

axon regeneration

regulation of protein stability

nuclear membrane

endoplasmic reticulum calcium ion homeostasis

glomerulus development

negative regulation of cellular pH reduction

regulation of protein localization

negative regulation of myeloid cell apoptosis

T cell differentiation in the thymus

positive regulation of peptidyl-serine phosphorylation

negative regulation of osteoblast proliferation

response to cytokine stimulus

response to nicotine

organ growth

positive regulation of multicellular organism growth

B cell proliferation

response to drug

response to hydrogen peroxide

protein homodimerization activity

T cell homeostasis

positive regulation of catalytic activity

myelin sheath

CD8-positive, alpha-beta T cell lineage commitment

response to peptide hormone stimulus

regulation of protein homodimerization activity

regulation of protein heterodimerization activity

negative regulation of neuron apoptosis

ear development

response to estrogen stimulus

regulation of viral genome replication

response to ethanol

positive regulation of melanocyte differentiation

negative regulation of mitotic cell cycle

negative regulation of retinal cell programmed cell death

regulation of mitochondrial membrane permeability

protein heterodimerization activity

focal adhesion formation

positive regulation of pigmentation during development

spleen development

thymus development

gut morphogenesis

developmental growth

oocyte development

positive regulation of skeletal muscle fiber development

pigment granule organization

homeostasis of number of cells within a tissue

response to glucocorticoid stimulus

BH3 domain binding

defense response to virus

regulation of cell cycle

response to protein stimulus

regulation of mitochondrial membrane potential

negative regulation of mitochondrial depolarization

regulation of calcium ion transport

apoptosis in response to endoplasmic reticulum stress

Apoptosis

Focal adhesion

Neurotrophin signaling pathway

Amyotrophic lateral sclerosis (ALS)

Pathways in cancer

Colorectal cancer

Prostate cancer

Small cell lung cancer

226606_s_at -1.072 6.176 -4.016 1.094e-03 0.227 -0.676 GTPBP5 GTP binding protein 5 (putative) 20 60191475 AI860690 20q13.33 Hs.340636 6

nucleotide binding

GTP binding

intracellular

mitochondrion

ribosome biogenesis

 
212711_at CAMSAP1 calmodulin regulated spectrin-associated protein 1 9 -137840153 AA019977 9q34.3 Hs.522493 2    
213753_x_at 0.615 8.952 3.444 3.556e-03 0.312 -1.676 EIF5A eukaryotic translation initiation factor 5A 17 7151041, 7151579, 7152011, 7152417 BF541557 17p13-p12 Hs.534314 52

RNA binding

translation initiation factor activity

translation elongation factor activity

nucleus

annulate lamellae

nuclear pore

cytoplasm

endoplasmic reticulum

cytosol

mRNA export from nucleus

translation

translational frameshifting

protein export from nucleus

nucleocytoplasmic transport

nucleocytoplasmic transport

induction of apoptosis

cell proliferation

peptidyl-lysine modification to hypusine

peptidyl-lysine modification to hypusine

protein transport

membrane

U6 snRNA binding

viral genome replication

ribosome binding

positive regulation of translational elongation

positive regulation of translational termination

positive regulation of translational initiation

protein N-terminus binding

intracellular protein transmembrane transport

 
238171_at -0.349 4.024 -3.115 6.998e-03 0.371 -2.253 SLC25A30 solute carrier family 25, member 30 13 -44865455 AI128486 13q14.13 Hs.591230 3

binding

mitochondrion

mitochondrial inner membrane

transport

mitochondrial transport

membrane

integral to membrane

 
224621_at MAPK1 mitogen-activated protein kinase 1 22 -20453318, -20443946 AA129773 22q11.2 22q11.21 Hs.431850 822

MAPKKK cascade

nucleotide binding

phosphotyrosine binding

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

cytosol

cytoskeleton

protein amino acid phosphorylation

induction of apoptosis

chemotaxis

response to DNA damage stimulus

cell cycle

Ras protein signal transduction

synaptic transmission

organ morphogenesis

transferase activity

MAP kinase 2 activity

cytosine metabolic process

lipopolysaccharide-mediated signaling pathway

response to lipopolysaccharide

response to exogenous dsRNA

interspecies interaction between organisms

negative regulation of cell differentiation

T cell receptor signaling pathway

B cell receptor signaling pathway

MAPK signaling pathway

ErbB signaling pathway

Chemokine signaling pathway

mTOR signaling pathway

Vascular smooth muscle contraction

Dorso-ventral axis formation

TGF-beta signaling pathway

Axon guidance

VEGF signaling pathway

Focal adhesion

Adherens junction

Gap junction

Toll-like receptor signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Fc gamma R-mediated phagocytosis

Long-term potentiation

Neurotrophin signaling pathway

Long-term depression

Regulation of actin cytoskeleton

Insulin signaling pathway

GnRH signaling pathway

Melanogenesis

Type II diabetes mellitus

Alzheimer's disease

Prion diseases

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Endometrial cancer

Glioma

Prostate cancer

Thyroid cancer

Melanoma

Bladder cancer

Chronic myeloid leukemia

Acute myeloid leukemia

Non-small cell lung cancer

237005_at LOC442075 hypothetical LOC442075 3   AI923935 3p25.3 Hs.666816 2    
225363_at 0.483 8.593 5.248 9.395e-05 0.162 1.362 PTEN phosphatase and tensin homolog 10 89613174 AK024986 10q23.3 Hs.500466 557

regulation of cyclin-dependent protein kinase activity

magnesium ion binding

angiogenesis

phosphatidylinositol-3-phosphatase activity

protein serine/threonine phosphatase activity

protein tyrosine phosphatase activity

platelet-derived growth factor receptor binding

protein binding

nucleus

cytoplasm

cytoplasm

cytosol

protein amino acid dephosphorylation

protein amino acid dephosphorylation

lipid metabolic process

induction of apoptosis

central nervous system development

protein tyrosine/serine/threonine phosphatase activity

negative regulation of cell proliferation

lipid binding

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

hydrolase activity

PDZ domain binding

negative regulation of cell migration

neuron projection development

regulation of protein stability

negative regulation of apoptosis

endothelial cell migration

inositol phosphate dephosphorylation

phosphoinositide dephosphorylation

platelet-derived growth factor receptor signaling pathway

cardiac muscle tissue development

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

negative regulation of focal adhesion formation

negative regulation of protein kinase B signaling cascade

Inositol phosphate metabolism

Phosphatidylinositol signaling system

p53 signaling pathway

Focal adhesion

Tight junction

Pathways in cancer

Endometrial cancer

Glioma

Prostate cancer

Melanoma

Small cell lung cancer

239208_s_at C21orf57 chromosome 21 open reading frame 57 21 46530694, 46530694 AW945538 21q22.3 Hs.474066 4

peptidase activity

metallopeptidase activity

zinc ion binding

metal ion binding

 
217071_s_at MTHFR 5,10-methylenetetrahydrofolate reductase (NADPH) 1 -11768373 AJ249275 1p36.3 Hs.214142 1776

methylenetetrahydrofolate reductase (NADPH) activity

methylenetetrahydrofolate reductase (NADPH) activity

protein binding

cytosol

cellular amino acid metabolic process

methionine metabolic process

blood circulation

oxidoreductase activity

oxidation reduction

One carbon pool by folate

Methane metabolism

Metabolic pathways

234464_s_at 0.475 4.366 3.790 1.739e-03 0.267 -1.069 EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) 17 45805588 AK021607 17q21.33 Hs.514330 15

magnesium ion binding

DNA binding

endonuclease activity

protein binding

nucleus

nucleolus

DNA repair

DNA recombination

response to DNA damage stimulus

hydrolase activity

Homologous recombination

218091_at AGFG1 ArfGAP with FG repeats 1 2 228045131 AI989512 2q36.3 Hs.352962 29

DNA binding

RNA binding

protein binding

nucleus

nuclear pore

Golgi apparatus

mRNA export from nucleus

transport

multicellular organismal development

spermatogenesis

ARF GTPase activator activity

zinc ion binding

cell differentiation

cytoplasmic vesicle

regulation of ARF GTPase activity

metal ion binding

 
205112_at 0.844 4.586 3.261 5.180e-03 0.347 -1.997 PLCE1 phospholipase C, epsilon 1 10 95743735 NM_016341 10q23 Hs.655033 35

Golgi membrane

activation of MAPK activity

regulation of cell growth

phosphoinositide phospholipase C activity

receptor signaling protein activity

guanyl-nucleotide exchange factor activity

calcium ion binding

intracellular

membrane fraction

cytoplasm

Golgi apparatus

cytosol

plasma membrane

phospholipid metabolic process

diacylglycerol biosynthetic process

regulation of smooth muscle contraction

cytoskeleton organization

epidermal growth factor receptor signaling pathway

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

elevation of cytosolic calcium ion concentration

activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway

heart development

regulation of G-protein coupled receptor protein signaling pathway

cell proliferation

lipid catabolic process

hydrolase activity

Ras GTPase binding

calcium-mediated signaling

calcium-mediated signaling

enzyme binding

glomerulus development

regulation of protein kinase activity

regulation of Ras protein signal transduction

inositol phosphate-mediated signaling

Inositol phosphate metabolism

Metabolic pathways

Calcium signaling pathway

Phosphatidylinositol signaling system

223309_x_at 0.333 7.849 2.547 2.216e-02 0.499 -3.228 PNPLA8 patatin-like phospholipase domain containing 8 7 -107899306 BG025248 7q31 Hs.617340 13

lysophospholipase activity

binding

ATP binding

intracellular

intracellular

membrane fraction

membrane fraction

cytoplasm

peroxisomal membrane

peroxisomal membrane

endoplasmic reticulum

Golgi apparatus

fatty acid metabolic process

fatty acid metabolic process

metabolic process

membrane

integral to membrane

lipid catabolic process

hydrolase activity

calcium-independent phospholipase A2 activity

calcium-independent phospholipase A2 activity

perinuclear region of cytoplasm

 
237354_at -0.257 3.038 -2.572 2.109e-02 0.497 -3.187 PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 16 14976333 N70298 16p13.11 Hs.370781 6

protein binding

lyase activity

carboxy-lyase activity

carboxylic acid metabolic process

pyridoxal phosphate binding

 
230098_at PHF20L1 PHD finger protein 20-like 1 8 133856785, 133856785, 133856785 AW612407 8q24.22 Hs.304362 4

nucleic acid binding

protein binding

zinc ion binding

metal ion binding

 
1562511_at LYST lysosomal trafficking regulator 1 -233890968 AL833100 1q42.1-q42.2 Hs.532411 23

protein binding

cytoplasm

protein transport

microtubule cytoskeleton

leukocyte chemotaxis

melanosome organization

endosome to lysosome transport via multivesicular body sorting pathway

mast cell secretory granule organization

natural killer cell mediated cytotoxicity

defense response to bacterium

defense response to protozoan

pigmentation

defense response to virus

 
210228_at CSF2 colony stimulating factor 2 (granulocyte-macrophage) 5 131437383 M11734 5q31.1 Hs.1349 172

cytokine activity

granulocyte macrophage colony-stimulating factor receptor binding

protein binding

extracellular region

extracellular space

immune response

positive regulation of cell proliferation

positive regulation of foam cell differentiation

positive regulation of tyrosine phosphorylation of Stat5 protein

myeloid dendritic cell differentiation

negative regulation of apoptosis

positive regulation of DNA replication

positive regulation of survival gene product expression

negative regulation of cytolysis

Cytokine-cytokine receptor interaction

Jak-STAT signaling pathway

Hematopoietic cell lineage

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

Fc epsilon RI signaling pathway

202722_s_at 0.724 6.119 3.103 7.171e-03 0.374 -2.274 GFPT1 glutamine-fructose-6-phosphate transaminase 1 2 -69400408 NM_002056 2p13 Hs.580300 29

glutamine-fructose-6-phosphate transaminase (isomerizing) activity

sugar binding

cytoplasm

fructose 6-phosphate metabolic process

energy reserve metabolic process

glutamine metabolic process

metabolic process

carbohydrate biosynthetic process

transferase activity

Alanine, aspartate and glutamate metabolism

Amino sugar and nucleotide sugar metabolism

Metabolic pathways

200740_s_at 0.257 9.325 2.452 2.672e-02 0.523 -3.385 SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 21 -45049959 NM_006936 21q22.3 Hs.474005 40

kinetochore

protein binding

cytoplasm

protein sumoylation

modification-dependent protein catabolic process

 
240570_at 0.569 2.731 2.563 2.145e-02 0.497 -3.201 INADL InaD-like (Drosophila) 1 61980736 AW006782 1p31.3 Hs.478125 24

protein binding

cellular_component

plasma membrane

tight junction

intracellular signaling cascade

apical plasma membrane

cell junction

Tight junction

236656_s_at LOC100130506 hypothetical protein LOC100130506 2   AW014647          
233916_at 0.481 3.388 3.481 3.293e-03 0.308 -1.611 KIAA1486 KIAA1486 2 225973845 AB040919 2q36.3 Hs.224409 4    
1564713_a_at -0.215 5.384 -2.248 3.981e-02 0.568 -3.716 FOXN4 forkhead box N4 12 -108200165 AF425597 12q24.11 Hs.528316 6

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

sequence-specific DNA binding

 
223982_s_at 0.275 8.445 2.363 3.186e-02 0.544 -3.532 PNPLA8 patatin-like phospholipase domain containing 8 7 -107899306 AB041261 7q31 Hs.617340 13

lysophospholipase activity

binding

ATP binding

intracellular

intracellular

membrane fraction

membrane fraction

cytoplasm

peroxisomal membrane

peroxisomal membrane

endoplasmic reticulum

Golgi apparatus

fatty acid metabolic process

fatty acid metabolic process

metabolic process

membrane

integral to membrane

lipid catabolic process

hydrolase activity

calcium-independent phospholipase A2 activity

calcium-independent phospholipase A2 activity

perinuclear region of cytoplasm

 
202948_at 0.419 5.509 2.262 3.879e-02 0.567 -3.695 IL1R1 interleukin 1 receptor, type I 2 102136833 NM_000877 2q12 Hs.701982 160

transmembrane receptor activity

interleukin-1, Type I, activating receptor activity

platelet-derived growth factor receptor binding

protein binding

integral to plasma membrane

cell surface receptor linked signal transduction

membrane

innate immune response

interleukin-1-mediated signaling pathway

response to interleukin-1

MAPK signaling pathway

Cytokine-cytokine receptor interaction

Apoptosis

Hematopoietic cell lineage

202644_s_at TNFAIP3 tumor necrosis factor, alpha-induced protein 3 6 138230273 NM_006290 6q23 Hs.211600 80

DNA binding

protein binding

nucleus

cytoplasm

centrosome

apoptosis

anti-apoptosis

peptidase activity

cysteine-type peptidase activity

zinc ion binding

modification-dependent protein catabolic process

negative regulation of I-kappaB kinase/NF-kappaB cascade

metal ion binding

 
1556209_at 0.880 4.095 2.595 2.012e-02 0.491 -3.147 CLEC2B C-type lectin domain family 2, member B 12 -9896234 CA447397 12p13-p12 Hs.85201 10

binding

sugar binding

integral to plasma membrane

membrane

 
204089_x_at MAP3K4 mitogen-activated protein kinase kinase kinase 4 6 161332811 NM_006724 6q26 Hs.390428 20

nucleotide binding

activation of MAPKK activity

magnesium ion binding

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

ATP binding

response to stress

JNK cascade

transferase activity

MAPK signaling pathway

GnRH signaling pathway

213519_s_at 0.768 6.327 5.259 9.203e-05 0.162 1.379 LAMA2 laminin, alpha 2 6 129245978 AI078169 6q22-q23 Hs.200841 40

receptor binding

structural molecule activity

extracellular region

basal lamina

laminin-1 complex

muscle organ development

regulation of cell adhesion

regulation of cell migration

positive regulation of synaptic transmission, cholinergic

sarcolemma

regulation of embryonic development

Focal adhesion

ECM-receptor interaction

Pathways in cancer

Small cell lung cancer

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

209512_at HSDL2 hydroxysteroid dehydrogenase like 2 9 114182171 BC004331 9q32 Hs.59486 6

binding

sterol carrier activity

oxidoreductase activity

oxidation reduction

 
204791_at NR2C1 nuclear receptor subfamily 2, group C, member 1 12 -93948315, -93938188 NM_003297 12q22 Hs.108301 Hs.707524 17

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

steroid hormone receptor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

transcription repressor activity

protein homodimerization activity

histone deacetylase binding

sequence-specific DNA binding

metal ion binding

 
214732_at -0.269 3.587 -2.132 4.969e-02 0.591 -3.899 SP1 Sp1 transcription factor 12 52060245, 52060694 AU121035 12q13.1 Hs.620754 Hs.649191 477

ossification

trophectodermal cell differentiation

liver development

embryonic placenta development

double-stranded DNA binding

transcription factor activity

RNA polymerase II transcription factor activity

intracellular

nucleus

nucleolus

cytoplasm

protein C-terminus binding

zinc ion binding

transcription activator activity

megakaryocyte differentiation

lung development

protein homodimerization activity

histone deacetylase binding

enucleate erythrocyte differentiation

sequence-specific DNA binding

interspecies interaction between organisms

positive regulation of transcription from RNA polymerase II promoter, global

metal ion binding

embryonic camera-type eye morphogenesis

embryonic skeletal system development

embryonic process involved in female pregnancy

definitive hemopoiesis

TGF-beta signaling pathway

Huntington's disease

214005_at 0.397 7.333 2.933 1.015e-02 0.416 -2.569 GGCX gamma-glutamyl carboxylase 2 -85629703 BE326952 2p12 Hs.77719 53

membrane fraction

endoplasmic reticulum

protein modification process

blood coagulation

gamma-glutamyl carboxylase activity

membrane

integral to membrane

ligase activity

peptidyl-glutamic acid carboxylation

 
242835_s_at 0.340 5.308 2.269 3.824e-02 0.565 -3.683 LOC728730 hypothetical LOC728730 2   AW772084 2p22.1        
239147_at -0.266 5.756 -2.488 2.489e-02 0.513 -3.326 ARSK arylsulfatase family, member K 5 94916580 AI243677 5q15 Hs.585051 5

arylsulfatase activity

calcium ion binding

extracellular region

metabolic process

hydrolase activity

 
228921_at -0.355 4.254 -2.786 1.370e-02 0.440 -2.823 SLC25A42 solute carrier family 25, member 42 19 19035807 AW170609 19p13.11 Hs.303669 3

binding

mitochondrion

mitochondrial inner membrane

transport

membrane

integral to membrane

 
217234_s_at 0.375 4.581 2.661 1.764e-02 0.473 -3.036 EZR ezrin 6 -159106760, -159106760 AF199015 6q25.2-q26 Hs.487027 158

ruffle

cytoplasm

cytosol

actin filament

plasma membrane

microvillus

cell cortex

cytoskeletal anchoring at plasma membrane

leukocyte adhesion

cytoskeletal protein binding

regulation of cell shape

extrinsic to membrane

membrane to membrane docking

filopodium

cortical cytoskeleton

apical part of cell

cell adhesion molecule binding

actin filament binding

actin filament bundle formation

Leukocyte transendothelial migration

Regulation of actin cytoskeleton

Pathogenic Escherichia coli infection - EHEC

202352_s_at 0.391 8.329 3.437 3.603e-03 0.314 -1.688 PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 17 -62767081, -62767080 AI446530 17q24.2 Hs.646575 39

protein binding

cytosol

proteasome regulatory particle

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

219343_at 0.795 8.355 2.780 1.386e-02 0.442 -2.833 CDC37L1 cell division cycle 37 homolog (S. cerevisiae)-like 1 9 4669565 NM_017913 9p24.1 Hs.561954 6

protein binding

cytoplasm

 
224961_at SCYL2 SCY1-like 2 (S. cerevisiae) 12 99185679 AB037781 12q23.1 Hs.506481 8

protein kinase activity

binding

ATP binding

cytoplasm

endosome

Golgi apparatus

protein amino acid phosphorylation

endosome membrane

membrane

clathrin-coated vesicle

cytoplasmic vesicle

perinuclear region of cytoplasm

 
218103_at 0.325 7.369 2.625 1.897e-02 0.488 -3.098 FTSJ3 FtsJ homolog 3 (E. coli) 17 -59250524 NM_017647 17q23.3 Hs.463785 10

nucleic acid binding

nucleus

nucleolus

rRNA processing

methyltransferase activity

transferase activity

rRNA methylation

methylation

 
210175_at C2orf3 chromosome 2 open reading frame 3 2 -75742801 BC000853 2p11.2-p11.1 Hs.303808 Hs.662279 13

transcription factor activity

protein binding

nucleus

regulation of transcription

 
226268_at RAB21 RAB21, member RAS oncogene family 12 70434924 AI309554 12q21.1 Hs.524590 12

Golgi membrane

nucleotide binding

protein binding

GTP binding

endosome

endoplasmic reticulum

Golgi apparatus

small GTPase mediated signal transduction

protein transport

membrane

cytoplasmic vesicle membrane

cytoplasmic vesicle

early endosome membrane

 
226183_at 0.244 6.525 2.136 4.934e-02 0.590 -3.893 GSK3B glycogen synthase kinase 3 beta 3 -121023493 AW139538 3q13.3 Hs.445733 Hs.593022 373

nucleotide binding

re-entry into mitotic cell cycle

p53 binding

glycogen synthase kinase 3 activity

ATP binding

nucleus

cytoplasm

cytosol

cytosol

glycogen metabolic process

anti-apoptosis

response to stress

ER overload response

intracellular signaling cascade

beta-catenin binding

organ morphogenesis

transferase activity

peptidyl-serine phosphorylation

growth cone

beta-catenin destruction complex

positive regulation of protein complex assembly

protein kinase A catalytic subunit binding

Axin-APC-beta-catenin-GSK3B complex

cell soma

dendritic shaft

membrane-bounded organelle

fat cell differentiation

positive regulation of protein export from nucleus

tau-protein kinase activity

NF-kappaB binding

Wnt receptor signaling pathway through beta-catenin

ErbB signaling pathway

Chemokine signaling pathway

Cell cycle

Wnt signaling pathway

Hedgehog signaling pathway

Axon guidance

Focal adhesion

T cell receptor signaling pathway

B cell receptor signaling pathway

Neurotrophin signaling pathway

Insulin signaling pathway

Melanogenesis

Alzheimer's disease

Pathways in cancer

Colorectal cancer

Endometrial cancer

Prostate cancer

Basal cell carcinoma

226528_at 0.498 7.599 2.843 1.222e-02 0.427 -2.726 MTX3 metaxin 3 5 -79308294 AI743044 5q14.1 Hs.531418 3

mitochondrion

mitochondrial outer membrane

protein targeting to mitochondrion

protein transport

membrane

 
1556182_x_at hCG_20426 hypothetical protein LOC441869 1 -1343664 BC018095 1p36.33 Hs.381222 3    
236728_at 1.198 4.987 4.272 6.491e-04 0.211 -0.236 LNPEP leucyl/cystinyl aminopeptidase 5 96297101, 96319911 AW070437 5q15 Hs.527199 Hs.656905 44

aminopeptidase activity

extracellular region

intracellular

plasma membrane

integral to plasma membrane

proteolysis

cell-cell signaling

female pregnancy

peptidase activity

metallopeptidase activity

zinc ion binding

metal ion binding

Renin-angiotensin system

228986_at 0.924 3.773 3.717 2.021e-03 0.273 -1.196 OSBPL8 oxysterol binding protein-like 8 12 -75269708 AW978375 12q14 Hs.430849 13

lipid transport

steroid metabolic process

 
221284_s_at SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 20 35406501, 35407970 NM_005417 20q12-q13 Hs.195659 589

nucleotide binding

response to acid

non-membrane spanning protein tyrosine kinase activity

SH3/SH2 adaptor activity

ATP binding

cytosol

plasma membrane

plasma membrane

caveola

response to stress

signal complex assembly

epidermal growth factor receptor signaling pathway

protein kinase cascade

Ras protein signal transduction

protein C-terminus binding

cell proliferation

cell-cell adhesion

cell migration

transferase activity

peptidyl-tyrosine phosphorylation

forebrain development

SH2 domain binding

positive regulation of apoptosis

interspecies interaction between organisms

transcytosis

positive regulation of cell adhesion

positive regulation of insulin receptor signaling pathway

platelet-derived growth factor receptor signaling pathway

nerve growth factor receptor signaling pathway

response to mineralocorticoid stimulus

ErbB signaling pathway

Endocytosis

VEGF signaling pathway

Focal adhesion

Adherens junction

Tight junction

Gap junction

GnRH signaling pathway

Epithelial cell signaling in Helicobacter pylori infection

221468_at XCR1 chemokine (C motif) receptor 1 3 -46037294 NM_005283 3p21.3 3p21.3-p21.1 Hs.248116 13

receptor activity

G-protein coupled receptor activity

chemokine receptor activity

plasma membrane

integral to plasma membrane

chemotaxis

inflammatory response

signal transduction

G-protein signaling, coupled to cyclic nucleotide second messenger

elevation of cytosolic calcium ion concentration

response to cytokine stimulus

release of sequestered calcium ion into cytosol

Cytokine-cytokine receptor interaction

Chemokine signaling pathway

218869_at -0.646 8.408 -2.613 1.940e-02 0.489 -3.117 MLYCD malonyl-CoA decarboxylase 16 82490230 NM_012213 16q24 Hs.644610 16

methylmalonyl-CoA decarboxylase activity

cytoplasm

mitochondrion

peroxisome

cytosol

acetyl-CoA biosynthetic process

fatty acid biosynthetic process

acyl-CoA metabolic process

lyase activity

regulation of fatty acid beta-oxidation

malonyl-CoA decarboxylase activity

beta-Alanine metabolism

Propanoate metabolism

Metabolic pathways

200694_s_at DDX24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 14 -93587020 NM_020414 14q32 Hs.510328 20

nucleotide binding

RNA binding

ATP-dependent RNA helicase activity

ATP binding

cellular_component

nucleolus

cytoplasm

RNA metabolic process

hydrolase activity

 
226254_s_at 0.387 7.197 2.684 1.685e-02 0.467 -2.998 KIAA1430 KIAA1430 4 -186317812 AI912523 4q35.1 Hs.535734 3    
212003_at 0.216 6.891 2.146 4.842e-02 0.589 -3.877 C1orf144 chromosome 1 open reading frame 144 1 16566169 BG171020 1p36.13 Hs.252967 2    
211672_s_at 0.488 6.332 2.839 1.230e-02 0.427 -2.731 ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 3 9809226 AF019888 3p25.3 Hs.323342 16

cytoplasm

cytoskeleton

Arp2/3 protein complex

actin filament polymerization

protein binding, bridging

cell projection

actin nucleation

actin filament binding

Fc gamma R-mediated phagocytosis

Regulation of actin cytoskeleton

207188_at -0.255 5.404 -2.277 3.762e-02 0.564 -3.669 CDK3 cyclin-dependent kinase 3 17 71508581 NM_001258 17q22-qter Hs.706766 21

nucleotide binding

cyclin-dependent protein kinase activity

protein binding

ATP binding

protein amino acid phosphorylation

cell cycle

mitosis

cell proliferation

transferase activity

cell division

 
229092_at 0.313 5.750 2.284 3.715e-02 0.562 -3.659 NR2F2 nuclear receptor subfamily 2, group F, member 2 15 94670160, 94675114, 94676797, 94677572 AI420144 15q26 Hs.657455 27

transcription factor activity

ligand-regulated transcription factor activity

steroid hormone receptor activity

transcription corepressor activity

nucleus

regulation of transcription from RNA polymerase II promoter

lipid metabolic process

signal transduction

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
204560_at 1.179 4.975 4.831 2.118e-04 0.172 0.696 FKBP5 FK506 binding protein 5 6 -35656311, -35649339, -35649339, -35649339 NM_004117 6p21.3-p21.2 Hs.407190 50

peptidyl-prolyl cis-trans isomerase activity

FK506 binding

nucleus

cytoplasm

protein folding

isomerase activity

heat shock protein binding

 
211968_s_at 0.418 9.335 2.234 4.092e-02 0.570 -3.739 HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 14 -101616827, -101616827 AI962933 14q32.33 Hs.525600 Hs.700831 275

nucleotide binding

ATP binding

cytoplasm

cytosol

cytosol

mitochondrial transport

response to unfolded protein

signal transduction

nitric-oxide synthase regulator activity

TPR domain binding

TPR domain binding

cellular chaperone-mediated protein complex assembly

protein refolding

melanosome

protein homodimerization activity

positive regulation of nitric oxide biosynthetic process

unfolded protein binding

mitochondrial outer membrane translocase complex assembly

Antigen processing and presentation

Pathways in cancer

Prostate cancer

217542_at 0.315 4.898 2.768 1.421e-02 0.446 -2.854 MDM2 Mdm2 p53 binding protein homolog (mouse) 12 67488237, 67489063 BE930512 12q14.3-q15 Hs.484551 555

negative regulation of transcription from RNA polymerase II promoter

negative regulation of transcription from RNA polymerase II promoter

p53 binding

ubiquitin-protein ligase activity

intracellular

insoluble fraction

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

cytosol

protein complex assembly

zinc ion binding

positive regulation of cell proliferation

ligase activity

basal transcription repressor activity

basal transcription repressor activity

enzyme binding

modification-dependent protein catabolic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process

protein ubiquitination during ubiquitin-dependent protein catabolic process

identical protein binding

interspecies interaction between organisms

metal ion binding

Cell cycle

p53 signaling pathway

Ubiquitin mediated proteolysis

Endocytosis

Pathways in cancer

Glioma

Prostate cancer

Melanoma

Bladder cancer

Chronic myeloid leukemia

201032_at 0.511 9.957 3.080 7.523e-03 0.376 -2.314 BLCAP bladder cancer associated protein 20 -35579232 NM_006698 20q11.2-q12 Hs.472651 Hs.718404 9

membrane

integral to membrane

 
1552257_a_at 0.321 5.887 3.325 4.538e-03 0.332 -1.884 TTLL12 tubulin tyrosine ligase-like family, member 12 22 -41892571 NM_015140 22q13.31 Hs.517670 6

tubulin-tyrosine ligase activity

protein modification process

 
213100_at UNC5B unc-5 homolog B (C. elegans) 10 72642303 AA127885 10q22.1 Hs.522997 12

receptor activity

protein binding

apoptosis

signal transduction

multicellular organismal development

membrane

integral to membrane

Axon guidance

202012_s_at 0.452 6.047 3.176 6.172e-03 0.361 -2.146 EXT2 exostoses (multiple) 2 11 44073674 AA196245 11p12-p11 Hs.368404 55

ossification

mesoderm formation

protein binding

endoplasmic reticulum

Golgi apparatus

glycosaminoglycan biosynthetic process

signal transduction

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

membrane

integral to membrane

cell differentiation

intrinsic to endoplasmic reticulum membrane

heparan sulfate N-acetylglucosaminyltransferase activity

protein homodimerization activity

protein heterodimerization activity

glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

Heparan sulfate biosynthesis

Metabolic pathways

203000_at STMN2 stathmin-like 2 8 80685934 BF967657 8q21.13 Hs.521651 23

protein binding

membrane fraction

soluble fraction

cytoplasm

intracellular signaling cascade

membrane

neuron differentiation

axon

growth cone

cell projection

perinuclear region of cytoplasm

 
39582_at 0.584 6.985 2.730 1.536e-02 0.457 -2.920 CYLD cylindromatosis (turban tumor syndrome) 16 49333461, 49333529 AL050166 16q12.1 Hs.578973 54

structural constituent of ribosome

ubiquitin thiolesterase activity

intracellular

cytoplasm

ribosome

cytoskeleton

translation

ubiquitin-dependent protein catabolic process

cell cycle

peptidase activity

cysteine-type peptidase activity

perinuclear region of cytoplasm

RIG-I-like receptor signaling pathway

1555439_at GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa 2 -197337344 AF465407 2q33.1 Hs.470996 10

transcription factor TFIIIC complex

DNA binding

RNA polymerase III transcription factor activity

binding

nucleus

transcription, DNA-dependent

5S class rRNA transcription

tRNA transcription from RNA polymerase III promoter

 
229302_at TMEM178 transmembrane protein 178 2 39746596 AA058832 2p22.1 Hs.40808 3

membrane

integral to membrane

 
222815_at 0.389 4.330 2.403 2.946e-02 0.536 -3.466 RLIM ring finger protein, LIM domain interacting X -73719537 BE966018 Xq13-q21 Hs.653288 9

transcription corepressor activity

ubiquitin-protein ligase activity

protein binding

zinc ion binding

negative regulation of transcription

ligase activity

transcriptional repressor complex

modification-dependent protein catabolic process

metal ion binding

 
210427_x_at 1.098 9.499 4.440 4.615e-04 0.193 0.049 ANXA2 annexin A2 15 -58426642, -58426641 BC001388 15q21-q22 Hs.511605 137

skeletal system development

angiogenesis

phospholipase inhibitor activity

calcium ion binding

calcium-dependent phospholipid binding

phosphatidylinositol-4,5-bisphosphate binding

extracellular region

basement membrane

soluble fraction

cytoplasm

early endosome

cytoskeletal protein binding

collagen fibril organization

sarcolemma

melanosome

fibrinolysis

protein complex

perinuclear region of cytoplasm

 
241199_x_at DPPA4 developmental pluripotency associated 4 3 -110527677 AV756594 3q13.13 Hs.317659 8

protein binding

nucleus

 
243912_x_at APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 22 37766618, 37766618 BF511268 22q13.1 Hs.659809 51

positive regulation of defense response to virus by host

RNA binding

cytidine deaminase activity

transcription, RNA-dependent

zinc ion binding

base conversion or substitution editing

hydrolase activity

apolipoprotein B mRNA editing enzyme complex

innate immune response

negative regulation of retroviral genome replication

metal ion binding

negative regulation of viral reproduction

Atrazine degradation

225557_at CSRNP1 cysteine-serine-rich nuclear protein 1 3 -39158347 AI091372 3p22 Hs.370950 4

molecular_function

transcription factor activity

cellular_component

nucleus

apoptosis

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

 
201566_x_at ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2 8739563 D13891 2p25 Hs.180919 76

negative regulation of transcription from RNA polymerase II promoter

protein binding

nucleus

nucleus

cytoplasm

multicellular organismal development

heart development

negative regulation of transcription

transcription repressor activity

enucleate erythrocyte differentiation

negative regulation of transcription factor activity

positive regulation of macrophage differentiation

TGF-beta signaling pathway

209183_s_at C10orf10 chromosome 10 open reading frame 10 10 -44791714 AL136653 10q11.21 Hs.93675 14

mitochondrion

 
228113_at -0.256 3.387 -2.714 1.585e-02 0.459 -2.946 RAB37 RAB37, member RAS oncogene family 17 70178850, 70244553, 70244950 R62453 17q25.1 Hs.592097 11

nucleotide binding

GTP binding

ER-Golgi intermediate compartment

small GTPase mediated signal transduction

protein transport

cytoplasmic vesicle

 
225521_at 0.426 5.871 2.370 3.140e-02 0.543 -3.520 ANAPC7 anaphase promoting complex subunit 7 12 -109297656, -109295087 AL137586 12q24.11 Hs.524741 30

binding

nucleoplasm

cytosol

cell cycle

mitosis

modification-dependent protein catabolic process

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

cell division

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Cell cycle

Ubiquitin mediated proteolysis

202440_s_at 0.590 5.903 3.324 4.555e-03 0.332 -1.887 ST5 suppression of tumorigenicity 5 11 -8671474, -8671474, -8671474 NM_005418 11p15 Hs.117715 11

protein binding

 
226058_at B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 16 -65739505 AI651445 16q22.1 Hs.718517 2

Golgi apparatus

protein amino acid glycosylation

galactosyltransferase activity

membrane

integral to membrane

transferase activity, transferring glycosyl groups

 
205852_at CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2 219532641 R51311 2q35 Hs.158460 11

regulation of cyclin-dependent protein kinase activity

cyclin-dependent protein kinase 5 activator complex

cyclin-dependent protein kinase 5 activator activity

 
209513_s_at HSDL2 hydroxysteroid dehydrogenase like 2 9 114182171 BC004331 9q32 Hs.59486 6

binding

sterol carrier activity

oxidoreductase activity

oxidation reduction

 
208581_x_at 1.315 10.736 4.885 1.903e-04 0.172 0.784 MT1X metallothionein 1X 16 55273882 NM_005952 16q13 Hs.374950 18

copper ion binding

zinc ion binding

response to metal ion

cadmium ion binding

metal ion binding

 
224952_at 0.454 4.534 3.576 2.704e-03 0.290 -1.444 TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 17 58440629 BF115054 17q23.2-q23.3 Hs.410889 3

binding

 
212185_x_at 1.151 10.784 4.508 4.030e-04 0.192 0.163 MT2A metallothionein 2A 16 55199978 NM_005953 16q13 Hs.647371 53

protein binding

cellular copper ion homeostasis

zinc ion binding

metal ion binding

 
224674_at -0.262 6.640 -2.617 1.926e-02 0.489 -3.110 TTYH3 tweety homolog 3 (Drosophila) 7 2638128 AI934753 7p22 Hs.440899 5

ion channel activity

chloride channel activity

calcium ion binding

plasma membrane

ion transport

integral to membrane

chloride ion binding

chloride channel complex

 
209149_s_at TM9SF1 transmembrane 9 superfamily member 1 14 -23729083, -23728192 BE899402 14q11.2 Hs.91586 5

membrane

integral to membrane

 
1558675_s_at 0.452 6.888 2.869 1.157e-02 0.426 -2.680 SDCCAG1 serologically defined colon cancer antigen 1 14 -49320281 AV724508 14q22 Hs.655964 8

nucleus

cytoplasm

 
201037_at 0.853 6.504 3.482 3.285e-03 0.308 -1.609 PFKP phosphofructokinase, platelet 10 3099751 NM_002627 10p15.3-p15.2 Hs.26010 24

nucleotide binding

magnesium ion binding

6-phosphofructokinase activity

6-phosphofructokinase activity

protein binding

ATP binding

cytoplasm

cytosol

cytosol

6-phosphofructokinase complex

glycolysis

kinase activity

transferase activity

Glycolysis / Gluconeogenesis

Pentose phosphate pathway

Fructose and mannose metabolism

Galactose metabolism

Biosynthesis of phenylpropanoids

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from shikimate pathway

Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

242996_at 0.496 3.503 2.658 1.773e-02 0.473 -3.040 MTRF1 mitochondrial translational release factor 1 13 -40688515 AI341686 13q14.1-q14.3 Hs.382176 8

cytoplasm

mitochondrion

regulation of translational termination

translation release factor activity, codon specific

 
208675_s_at 0.305 8.268 2.463 2.617e-02 0.520 -3.368 DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase 1 -20850846 D29643 1p36.1 Hs.523145 12

dolichyl-diphosphooligosaccharide-protein glycotransferase activity

protein binding

endoplasmic reticulum

microsome

protein amino acid terminal N-glycosylation

oligosaccharyltransferase complex

membrane

integral to membrane

transferase activity

protein amino acid N-linked glycosylation via asparagine

response to cytokine stimulus

T cell activation

N-Glycan biosynthesis

Metabolic pathways

218648_at CRTC3 CREB regulated transcription coactivator 3 15 88874201 NM_022769 15q26.1 Hs.567572 10

nucleus

cytoplasm

interspecies interaction between organisms

regulation of transcription

 
212460_at C14orf147 chromosome 14 open reading frame 147 14 -33971894 BE738425 14q13.1 Hs.269909 5

serine C-palmitoyltransferase activity

protein binding

endoplasmic reticulum

membrane

integral to membrane

serine C-palmitoyltransferase complex

sphingolipid biosynthetic process

 
220611_at -0.240 4.182 -2.411 2.901e-02 0.534 -3.454 DAB1 disabled homolog 1 (Drosophila) 1 -57236166 NM_021080 1p32-p31 Hs.477370 37

multicellular organismal development

nervous system development

cell differentiation

 
236263_at SHH sonic hedgehog homolog (Drosophila) 7 -155288318 AI192528 7q36 Hs.164537 144

patterning of blood vessels

vasculogenesis

metanephros development

branching involved in ureteric bud morphogenesis

cell fate specification

neural crest cell migration

neural tube formation

positive regulation of neuroblast proliferation

positive regulation of mesenchymal cell proliferation

osteoblast development

patched binding

protein binding

extracellular region

extracellular space

plasma membrane

signal transduction

positive regulation of hh target transcription factor activity

cell-cell signaling

pattern specification process

axon guidance

ventral midline development

open tracheal system development

salivary gland morphogenesis

hindgut morphogenesis

heart development

blood coagulation

androgen metabolic process

peptidase activity

anterior/posterior pattern formation

cell surface

oligodendrocyte development

intein-mediated protein splicing

spinal cord dorsal/ventral patterning

dorsal/ventral neural tube patterning

smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation

positive regulation of granule cell precursor proliferation

telencephalon regionalization

regulation of proteolysis

lung development

negative regulation of cell migration

male genitalia development

prostate gland development

regulation of epithelial cell differentiation

forebrain development

midbrain development

hindbrain development

hair follicle morphogenesis

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of T cell proliferation

negative regulation of protein catabolic process

positive regulation of protein import into nucleus

odontogenesis of dentine-containing tooth

embryonic digit morphogenesis

camera-type eye development

laminin-1 binding

tongue morphogenesis

membrane raft

myoblast differentiation

regulation of transcription

negative regulation of cell differentiation

positive regulation of neuron differentiation

positive regulation of transcription from RNA polymerase II promoter

negative regulation of alpha-beta T cell differentiation

digestive tract morphogenesis

embryonic organ development

developmental growth

neuron fate commitment

response to axon injury

embryonic skeletal system development

formation of anatomical boundary

striated muscle cell differentiation

Bergmann glial cell differentiation

Hedgehog signaling pathway

Pathways in cancer

Basal cell carcinoma

221519_at 0.333 7.992 2.655 1.786e-02 0.475 -3.047 FBXW4 F-box and WD repeat domain containing 4 10 -103360410 AF281859 10q24 Hs.500822 16

ubiquitin ligase complex

molecular_function

ubiquitin-dependent protein catabolic process

multicellular organismal development

Wnt receptor signaling pathway

embryonic limb morphogenesis

limb development

 
210381_s_at CCKBR cholecystokinin B receptor 11 6237541 BC000740 11p15.4 Hs.203 74

phosphoinositide phospholipase C activity

receptor activity

G-protein coupled receptor activity

protein binding

membrane fraction

plasma membrane

integral to plasma membrane

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

elevation of cytosolic calcium ion concentration

digestion

sensory perception

feeding behavior

positive regulation of cell proliferation

gastrin receptor activity

1-phosphatidylinositol-3-kinase regulator activity

Calcium signaling pathway

Neuroactive ligand-receptor interaction

241817_at C3orf62 chromosome 3 open reading frame 62 3 -49281033 AA729235 3p21.31 Hs.403828 3    
222291_at 0.855 4.141 5.180 1.071e-04 0.162 1.255 FAM149A family with sequence similarity 149, member A 4 187302988, 187307320 AI478795 4q35.1 Hs.357025 3    
240607_at -0.323 6.006 -2.935 1.011e-02 0.415 -2.566 MIAT myocardial infarction associated transcript (non-protein coding) 22 25383483 AI692560 22q12.1 Hs.517502 3    
217718_s_at YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 20 42947757 NM_014052 20q13.1 Hs.643544 109

cytoplasm

cytosol

protein targeting

Ras protein signal transduction

activation of pro-apoptotic gene products

enzyme binding

protein domain specific binding

negative regulation of protein amino acid dephosphorylation

melanosome

positive regulation of catalytic activity

perinuclear region of cytoplasm

Cell cycle

Neurotrophin signaling pathway

234195_at -0.248 5.146 -2.861 1.176e-02 0.426 -2.694 TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 8 23016378 AK026079 8p22-p21 Hs.655801 43

transmembrane receptor activity

plasma membrane

integral to plasma membrane

apoptosis

signal transduction

anchored to membrane

Cytokine-cytokine receptor interaction

Apoptosis

Natural killer cell mediated cytotoxicity

226279_at PRSS23 protease, serine, 23 11 86189138 AW471145 11q14.1 Hs.25338 13

serine-type endopeptidase activity

extracellular region

nucleus

proteolysis

peptidase activity

 
208471_at 0.410 4.720 2.851 1.202e-02 0.426 -2.712 HPR haptoglobin-related protein 16 70654625 NM_020995 16q22.1 Hs.655361 17

catalytic activity

serine-type endopeptidase activity

extracellular region

proteolysis

hemoglobin binding

spherical high-density lipoprotein particle

 
211746_x_at 0.232 10.723 3.007 8.738e-03 0.394 -2.442 PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 11 -14492087, -14482998, -14482998 BC005932 11p15.1 Hs.102798 Hs.445711 52

RNA binding

threonine-type endopeptidase activity

protein binding

nucleus

cytoplasm

cytosol

proteasome core complex

polysome

ubiquitin-dependent protein catabolic process

peptidase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

proteolysis involved in cellular protein catabolic process

Proteasome

212296_at 0.317 10.020 2.570 2.116e-02 0.497 -3.189 PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 2 161873031 NM_005805 2q24.2 Hs.567410 15

proteasome complex

ubiquitin thiolesterase activity

protein binding

cytosol

ubiquitin-dependent protein catabolic process

peptidase activity

metallopeptidase activity

zinc ion binding

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

metal ion binding

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

protein K63-linked deubiquitination

Proteasome

210253_at 0.354 4.230 2.582 2.066e-02 0.497 -3.169 HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 11 20341806, 20341822, 20341864, 20341978, 20342262 AF092095 11p15.1 Hs.90753 31

RNA polymerase II transcription factor activity

transcription coactivator activity

protein binding

nucleus

nuclear envelope

cytoplasm

regulation of transcription from RNA polymerase II promoter

anti-apoptosis

induction of apoptosis

multicellular organismal development

oxidoreductase activity

cell differentiation

regulation of apoptosis

interspecies interaction between organisms

regulation of angiogenesis

nuclear import

oxidation reduction

 
1556228_a_at 0.289 5.248 2.314 3.502e-02 0.555 -3.610 VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 8 -67705041 AF088033 8q13 Hs.632066 16

ubiquitin-specific protease activity

cytoplasm

endoplasmic reticulum

Golgi apparatus

Golgi stack

peptidase activity

cysteine-type peptidase activity

protein ubiquitination

modification-dependent protein catabolic process

 
228244_at BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 19 50373842 BF062383 19q13.32 Hs.103902 Hs.719016 7

eye development

molecular_function

cytoplasm

cytosol

platelet activation

BLOC-1 complex

BLOC-1 complex

melanosome organization

positive regulation of natural killer cell activation

secretion of lysosomal enzymes

response to drug

identical protein binding

pigmentation during development

platelet dense granule organization

 
224513_s_at UBQLN4 ubiquilin 4 1 -154271715 BC006410 1q21 Hs.283739 9

nucleus

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

cytosol

biological_process

identical protein binding

 
220254_at LRP12 low density lipoprotein-related protein 12 8 -105570642 NM_013437 8q22.2-q23.1 Hs.600630 8

receptor activity

low-density lipoprotein receptor activity

protein binding

nucleolus

cytoplasm

plasma membrane

integral to plasma membrane

coated pit

endocytosis

signal transduction

regulation of growth

 
234329_at -0.252 3.485 -2.312 3.516e-02 0.555 -3.614 CLIC5 chloride intracellular channel 5 6 -45974165, -45974165 AL050336 6p21.1-p12.1 Hs.485489 15

voltage-gated ion channel activity

voltage-gated chloride channel activity

protein binding

insoluble fraction

cytoplasm

Golgi apparatus

centrosome

cell cortex

ion transport

chloride transport

female pregnancy

actin cytoskeleton

membrane

integral to membrane

chloride ion binding

chloride channel complex

 
220901_at -0.574 5.578 -2.767 1.423e-02 0.446 -2.855 GPR157 G protein-coupled receptor 157 1 -9087062 NM_024980 1p36.23 Hs.632367 5

G-protein coupled receptor activity

plasma membrane

G-protein coupled receptor protein signaling pathway

integral to membrane

 
235635_at ARHGAP5 Rho GTPase activating protein 5 14 31616245 N50119 14q12 Hs.592313 19

GTPase activity

GTPase activator activity

Rho GTPase activator activity

GTP binding

intracellular

cytoplasm

cell adhesion

signal transduction

small GTPase mediated signal transduction

Rho protein signal transduction

membrane

SH2 domain binding

Focal adhesion

Leukocyte transendothelial migration

1556121_at NAP1L1 nucleosome assembly protein 1-like 1 12 -74724938 AK021751 12q21.2 Hs.524599 Hs.695185 17

protein binding

nucleus

chromatin assembly complex

DNA replication

nucleosome assembly

positive regulation of cell proliferation

melanosome

 
226494_at KIAA1543 KIAA1543 19 7566787 AB040976 19p13.2 Hs.17686 9

molecular_function

protein binding

cellular_component

biological_process

 
222033_s_at -0.262 7.332 -2.231 4.117e-02 0.571 -3.744 FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 13 -27871181, -27857687, -27840233, -27772482 AA058828 13q12 Hs.654360 228

nucleotide binding

patterning of blood vessels

receptor activity

vascular endothelial growth factor receptor activity

ATP binding

extracellular region

extracellular space

cytoplasm

plasma membrane

plasma membrane

integral to plasma membrane

protein amino acid phosphorylation

transmembrane receptor protein tyrosine kinase signaling pathway

multicellular organismal development

female pregnancy

positive regulation of cell proliferation

cell migration

transferase activity

growth factor binding

cell differentiation

positive regulation of vascular endothelial growth factor receptor signaling pathway

identical protein binding

Cytokine-cytokine receptor interaction

Endocytosis

Focal adhesion

1554864_a_at SDC3 syndecan 3 1 -31114899 AF248634 1pter-p22.3 Hs.158287 35

cytoskeletal protein binding

membrane

integral to membrane

ECM-receptor interaction

Cell adhesion molecules (CAMs)

204336_s_at RGS19 regulator of G-protein signaling 19 20 -62174978, -62174978 NM_005873 20q13.33 Hs.422336 25

signal transducer activity

protein binding

membrane fraction

Golgi apparatus

heterotrimeric G-protein complex

autophagy

G-protein coupled receptor protein signaling pathway

small GTPase mediated signal transduction

negative regulation of signal transduction

membrane

 
207922_s_at 0.232 7.479 2.166 4.659e-02 0.582 -3.846 MAEA macrophage erythroblast attacher 4 1273671 NM_005882 4p16.3 Hs.139896 5

actin binding

membrane fraction

nucleus

cytoplasm

spindle

contractile ring

cytoskeleton

plasma membrane

integral to plasma membrane

cell cycle

cell adhesion

regulation of mitotic cell cycle

nuclear matrix

negative regulation of myeloid cell apoptosis

erythrocyte maturation

cell division

 
226247_at PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 10 124124209, 124141832 AI346026 10q26.13 Hs.643512 16

phospholipid binding

cellular_component

nucleus

cytoplasm

plasma membrane

biological_process

 
207257_at -0.192 4.767 -2.194 4.414e-02 0.579 -3.801 EPO erythropoietin 7 100156358 NM_000799 7q22 Hs.2303 177

response to hypoxia

erythropoietin receptor binding

hormone activity

protein binding

extracellular region

extracellular space

regulation of transcription from RNA polymerase II promoter

apoptosis

signal transduction

embryo implantation

blood circulation

positive regulation of cell proliferation

erythrocyte differentiation

positive regulation of tyrosine phosphorylation of Stat5 protein

hemoglobin biosynthetic process

positive regulation of gene-specific transcription

erythrocyte maturation

positive regulation of DNA replication

positive regulation of Ras protein signal transduction

Cytokine-cytokine receptor interaction

Jak-STAT signaling pathway

Hematopoietic cell lineage

201174_s_at 0.384 8.264 3.829 1.605e-03 0.259 -1.001 TERF2IP telomeric repeat binding factor 2, interacting protein 16 74239184 NM_018975 16q23.1 Hs.301419 25

nuclear chromosome

nuclear telomere cap complex

DNA binding

protein binding

nucleus

nucleoplasm

cytoplasm

telomere maintenance via telomerase

Mre11 complex

protection from non-homologous end joining at telomere

negative regulation of telomere maintenance

telomeric DNA binding

regulation of transcription

protein localization to telomere

 
201323_at EBNA1BP2 EBNA1 binding protein 2 1 -43402432, -43402432 NM_006824 1p35-p33 Hs.346868 20

protein binding

membrane fraction

nucleus

nucleolus

ribosome biogenesis

 
214328_s_at HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 14 -101616827, -101616827 R01140 14q32.33 Hs.525600 Hs.700831 275

nucleotide binding

ATP binding

cytoplasm

cytosol

cytosol

mitochondrial transport

response to unfolded protein

signal transduction

nitric-oxide synthase regulator activity

TPR domain binding

TPR domain binding

cellular chaperone-mediated protein complex assembly

protein refolding

melanosome

protein homodimerization activity

positive regulation of nitric oxide biosynthetic process

unfolded protein binding

mitochondrial outer membrane translocase complex assembly

Antigen processing and presentation

Pathways in cancer

Prostate cancer

222664_at 0.586 5.271 4.705 2.720e-04 0.175 0.489 KCTD15 potassium channel tetramerisation domain containing 15 19 38979590 AI808448 19q13.11 Hs.221873 Hs.606506 12

voltage-gated potassium channel activity

protein binding

potassium ion transport

voltage-gated potassium channel complex

membrane

 
242545_at 0.460 5.907 3.380 4.050e-03 0.323 -1.787 TTLL11 tubulin tyrosine ligase-like family, member 11 9 -123791010, -123624025 AA007347 9q33.2 Hs.640663 Hs.644262 5

tubulin-tyrosine ligase activity

cilium

microtubule basal body

protein modification process

ligase activity

 
204980_at CLOCK clock homolog (mouse) 4 -55993416 NM_004898 4q12 Hs.436975 72

transcription factor activity

histone acetyltransferase activity

signal transducer activity

protein binding

nucleus

transcription factor complex

nucleolus

cytoplasm

signal transduction

circadian rhythm

acyltransferase activity

photoperiodism

transferase activity

positive regulation of transcription from RNA polymerase II promoter

Circadian rhythm - mammal

224812_at HIBADH 3-hydroxyisobutyrate dehydrogenase 7 -27531585 AL577446 7p15.2 Hs.406758 9

phosphogluconate dehydrogenase (decarboxylating) activity

binding

mitochondrion

pentose-phosphate shunt

valine metabolic process

3-hydroxyisobutyrate dehydrogenase activity

oxidoreductase activity

NAD or NADH binding

oxidation reduction

Valine, leucine and isoleucine degradation

Metabolic pathways

229872_s_at 1.759 6.025 4.111 9.013e-04 0.220 -0.513 LOC100132999 hypothetical protein LOC100132999 1   AA532655 1q21.2 Hs.670106      
201123_s_at 1.022 9.932 3.405 3.854e-03 0.319 -1.745 EIF5A eukaryotic translation initiation factor 5A 17 7151041, 7151579, 7152011, 7152417 NM_001970 17p13-p12 Hs.534314 52

RNA binding

translation initiation factor activity

translation elongation factor activity

nucleus

annulate lamellae

nuclear pore

cytoplasm

endoplasmic reticulum

cytosol

mRNA export from nucleus

translation

translational frameshifting

protein export from nucleus

nucleocytoplasmic transport

nucleocytoplasmic transport

induction of apoptosis

cell proliferation

peptidyl-lysine modification to hypusine

peptidyl-lysine modification to hypusine

protein transport

membrane

U6 snRNA binding

viral genome replication

ribosome binding

positive regulation of translational elongation

positive regulation of translational termination

positive regulation of translational initiation

protein N-terminus binding

intracellular protein transmembrane transport

 
220027_s_at RASIP1 Ras interacting protein 1 19 -53915653 NM_017805 19q13.33 Hs.233955 4

cytoplasm

Golgi apparatus

Golgi stack

signal transduction

perinuclear region of cytoplasm

 
214789_x_at 0.279 7.334 2.274 3.786e-02 0.564 -3.675 SFRS2B splicing factor, arginine/serine-rich 2B 11 94439703 AA524274 11q22 Hs.476680 Hs.713908 6

nucleotide binding

RNA binding

nucleus

mRNA processing

RNA splicing

 
1560145_at MKLN1 muskelin 1, intracellular mediator containing kelch motifs 7 130445394, 130663134 BQ942131 7q32 Hs.44693 13

protein binding

cytoplasm

signal transduction

 
244409_at -0.319 6.286 -2.247 3.987e-02 0.568 -3.717 CCDC154 coiled-coil domain containing 154 16 -1424390 AW612232 16p13.3 Hs.355232 1    
226508_at 0.242 7.975 2.393 3.001e-02 0.539 -3.482 PHC3 polyhomeotic homolog 3 (Drosophila) 3 -171288061 AI042019 3q26.2 Hs.529592 Hs.694467 10

DNA binding

nucleus

multicellular organismal development

zinc ion binding

metal ion binding

 
224977_at C6orf89 chromosome 6 open reading frame 89 6 36961617 AL119182 6p21.2 Hs.433381 10

membrane

integral to membrane

 
222457_s_at 0.488 6.726 2.270 3.814e-02 0.565 -3.681 LIMA1 LIM domain and actin binding 1 12 -48855829, -48855829 BC001247 12q13 Hs.525419 23

stress fiber

actin monomer binding

cytoplasm

focal adhesion

zinc ion binding

actin cytoskeleton

cell junction

negative regulation of actin filament depolymerization

ruffle organization

metal ion binding

actin filament binding

actin filament bundle formation

 
200059_s_at 0.382 10.457 2.658 1.773e-02 0.473 -3.040 RHOA ras homolog gene family, member A 3 -49371582 BC001360 3p21.3 Hs.247077 Hs.709788 348

nucleotide binding

magnesium ion binding

cell morphogenesis

GTPase activity

protein binding

GTP binding

intracellular

nucleus

cytoplasm

cytoskeleton

plasma membrane

regulation of transcription from RNA polymerase II promoter

cell adhesion

cell-matrix adhesion

small GTPase mediated signal transduction

Rho protein signal transduction

skeletal muscle tissue development

myosin binding

actin cytoskeleton organization

cell differentiation

positive regulation of NF-kappaB import into nucleus

positive regulation of I-kappaB kinase/NF-kappaB cascade

negative regulation of neuron apoptosis

interspecies interaction between organisms

negative regulation of neuron differentiation

positive regulation of neuron differentiation

positive regulation of stress fiber formation

Chemokine signaling pathway

Vascular smooth muscle contraction

Wnt signaling pathway

TGF-beta signaling pathway

Axon guidance

Focal adhesion

Adherens junction

Tight junction

T cell receptor signaling pathway

Leukocyte transendothelial migration

Neurotrophin signaling pathway

Regulation of actin cytoskeleton

Pathogenic Escherichia coli infection - EHEC

Pathways in cancer

1554114_s_at SSH2 slingshot homolog 2 (Drosophila) 17 -24977090 AB072359 17q11.2 Hs.654754 11

actin binding

protein tyrosine phosphatase activity

cytoplasm

cytoskeleton

protein amino acid dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

hydrolase activity

actin cytoskeleton organization

Regulation of actin cytoskeleton

212219_at 0.482 8.217 4.445 4.572e-04 0.193 0.057 PSME4 proteasome (prosome, macropain) activator subunit 4 2 -53944707 D38521 2p16.2 Hs.413801 30

binding

nucleus

cytosol

multicellular organismal development

spermatogenesis

nuclear speck

cell differentiation

protein complex

Proteasome

206875_s_at SLK STE20-like kinase (yeast) 10 105717459 NM_014720 10q24.33 Hs.591922 16

nucleotide binding

DNA binding

nuclease activity

protein serine/threonine kinase activity

ATP binding

cytoplasm

plasma membrane

nucleotide-excision repair

protein amino acid phosphorylation

apoptosis

transferase activity

 
207991_x_at -0.319 3.844 -2.975 9.324e-03 0.401 -2.497 ACRV1 acrosomal vesicle protein 1 11 -125047438 NM_020113 11q23-q24 Hs.169222 Hs.596575 12

acrosomal vesicle

multicellular organismal development

 
204342_at SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 1 -108478969, -108478969 NM_013386 1p13.3 Hs.656870 4

binding

calcium ion binding

mitochondrion

mitochondrial inner membrane

transport

membrane

integral to membrane

 
225522_at 0.586 7.015 2.731 1.533e-02 0.457 -2.918 AAK1 AP2 associated kinase 1 2 -69538630 AW628987 2p14 Hs.468878 19

nucleotide binding

protein serine/threonine kinase activity

ATP binding

plasma membrane

coated pit

protein amino acid phosphorylation

transferase activity

 
216854_at GDF11 growth differentiation factor 11 12 54423330 AF028333 12q13.2 Hs.600883 10

skeletal system development

ureteric bud development

cytokine activity

protein binding

extracellular region

extracellular space

nervous system development

mesoderm development

growth factor activity

negative regulation of cell proliferation

organ morphogenesis

spinal cord anterior/posterior patterning

pancreas development

growth

negative regulation of cell differentiation

cell maturation

camera-type eye morphogenesis

 
217771_at 0.636 4.486 3.343 4.375e-03 0.328 -1.853 GOLM1 golgi membrane protein 1 9 -87830877, -87830877 NM_016548 9q21.33 Hs.494337 22

Golgi apparatus

integral to plasma membrane

membrane

 
243901_at ALDOB aldolase B, fructose-bisphosphate 9 -103222662 AV658701 9q21.3-q22.2 Hs.530274 40

fructose-bisphosphate aldolase activity

microtubule organizing center

glycolysis

NADH oxidation

cytoskeletal protein binding

metabolic process

lyase activity

fructose 1,6-bisphosphate metabolic process

positive regulation of ATPase activity

centriolar satellite

identical protein binding

ATPase binding

fructose binding

vacuolar proton-transporting V-type ATPase complex assembly

Glycolysis / Gluconeogenesis

Pentose phosphate pathway

Fructose and mannose metabolism

Carbon fixation in photosynthetic organisms

Biosynthesis of phenylpropanoids

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from shikimate pathway

Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

225125_at MMGT1 membrane magnesium transporter 1 X -134871896 BF978280 Xq26.3 Hs.110702 7

magnesium ion binding

cytoplasm

early endosome

endoplasmic reticulum

Golgi apparatus

plasma membrane

transport

cobalt ion transport

copper ion transport

cobalt ion transmembrane transporter activity

ferrous iron transmembrane transporter activity

magnesium ion transmembrane transporter activity

ferrous iron transport

magnesium ion transport

integral to membrane

 
206995_x_at -0.543 4.988 -4.096 9.285e-04 0.222 -0.538 SCARF1 scavenger receptor class F, member 1 17 -1483902, -1483901 NM_003693 17p13.3 Hs.647430 6

scavenger receptor activity

protein binding

cholesterol catabolic process

receptor-mediated endocytosis

cell adhesion

membrane

integral to membrane

low-density lipoprotein binding

 
227903_x_at 0.316 4.755 3.515 3.068e-03 0.301 -1.551 C19orf20 chromosome 19 open reading frame 20 19 458496 AI990682 19p13.3 Hs.369613 6

cytoplasm

centrosome

cytoskeleton

microtubule

cilium

microtubule basal body

multicellular organismal development

spermatogenesis

flagellum

cell differentiation

axon

dendrite

cilium axoneme

flagellar axoneme

 
238478_at 0.460 5.713 2.468 2.590e-02 0.518 -3.359 BNC2 basonuclin 2 9 -16399500 H97386 9p22.3-p22.2 Hs.656581 Hs.693437 10

intracellular

nucleus

cytoplasm

plasma membrane

zinc ion binding

regulation of transcription

metal ion binding

 
207877_s_at NVL nuclear VCP-like 1 -222481658 NM_002533 1q41-q42.2 Hs.497867 10

nucleotide binding

ATP binding

nucleus

nucleolus

nucleoside-triphosphatase activity

 
203643_at ERF Ets2 repressor factor 19 -47443556 NM_006494 19q13 Hs.655969 17

transcription factor activity

ligand-regulated transcription factor activity

transcription corepressor activity

nucleus

regulation of transcription from RNA polymerase II promoter

cell proliferation

sequence-specific DNA binding

 
223708_at C1QTNF4 C1q and tumor necrosis factor related protein 4 11 -47567791 AF329838 11q11 Hs.662633 3

extracellular region

 
209214_s_at EWSR1 Ewing sarcoma breakpoint region 1 22 27993997, 27993997 BC004817 22q12.2 Hs.374477 90

nucleotide binding

RNA binding

calmodulin binding

intracellular

nucleus

cytoplasm

plasma membrane

zinc ion binding

regulation of transcription

metal ion binding

 
218694_at ARMCX1 armadillo repeat containing, X-linked 1 X 100692169 NM_016608 Xq21.33-q22.2 Hs.9728 8

binding

membrane

integral to membrane

 
209398_at HIST1H1C histone cluster 1, H1c 6 -26163946 BC002649 6p21.3 Hs.7644 17

nucleosome

DNA binding

protein binding

nucleus

chromosome

nucleosome assembly

nucleosome positioning

 
1553429_at FLJ31713 hypothetical protein FLJ31713 9   NM_152575 9q32 Hs.350785 1    
229068_at CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 5 10303281 BF197357 5p15.2 Hs.1600 30

nucleotide binding

ATP binding

nucleus

nucleolus

cytoplasm

chaperonin-containing T-complex

protein folding

unfolded protein binding

 
46323_at -0.490 6.002 -4.124 8.764e-04 0.219 -0.489 CANT1 calcium activated nucleotidase 1 17 -74499392 AL120741 17q25.3 Hs.8859 13

signal transducer activity

calcium ion binding

endoplasmic reticulum

Golgi apparatus

membrane

integral to membrane

hydrolase activity

nucleoside-diphosphatase activity

positive regulation of I-kappaB kinase/NF-kappaB cascade

Purine metabolism

Pyrimidine metabolism

234870_at TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 2 159533391 AK000401 2q24.2 Hs.61590 6

binding

plasma membrane

postsynaptic density

cell junction

synapse

postsynaptic membrane

 
1556006_s_at CSNK1A1 casein kinase 1, alpha 1 5 -148855037 BQ025347 5q32 Hs.529862 Hs.712555 53

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

cytosol

protein amino acid phosphorylation

Wnt receptor signaling pathway

transferase activity

Wnt signaling pathway

Hedgehog signaling pathway

231480_at SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 5 1254709 AI636105 5p15.33 Hs.481478 10

neurotransmitter:sodium symporter activity

integral to plasma membrane

neurotransmitter transport

neutral amino acid transmembrane transporter activity

symporter activity

neutral amino acid transport

membrane

 
208776_at 0.485 7.169 2.853 1.195e-02 0.426 -2.707 PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 17 27795614 BF432873 17q11.2 Hs.655396 41

proteasome complex

protein binding

cytosol

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

231871_at 0.463 4.686 3.720 2.011e-03 0.273 -1.192 GPR180 G protein-coupled receptor 180 13 94052104 AU160685 13q32.1 Hs.657472 7

membrane

integral to membrane

 
219250_s_at FLRT3 fibronectin leucine rich transmembrane protein 3 20 -14252642, -14252642 NM_013281 20p11 Hs.41296 9

receptor signaling protein activity

proteinaceous extracellular matrix

integral to plasma membrane

cell adhesion

biological_process

membrane

protein binding, bridging

 
213464_at SHC2 SHC (Src homology 2 domain containing) transforming protein 2 19 -367582 AV705938 19p13.3 Hs.30965 11

protein binding

cellular_component

intracellular signaling cascade

Ras protein signal transduction

ErbB signaling pathway

Chemokine signaling pathway

VEGF signaling pathway

Focal adhesion

Natural killer cell mediated cytotoxicity

Neurotrophin signaling pathway

Insulin signaling pathway

Glioma

Chronic myeloid leukemia

212036_s_at 0.603 7.762 4.061 9.976e-04 0.224 -0.598 PNN pinin, desmosome associated protein 14 38714137 AW152664 14q21.1 Hs.409965 30

DNA binding

structural molecule activity

protein binding

nucleus

spliceosomal complex

nucleolus

cytoplasm

intermediate filament

plasma membrane

mRNA processing

cell adhesion

RNA splicing

nuclear speck

desmosome

regulation of transcription

 
210564_x_at 0.684 7.111 3.192 5.976e-03 0.357 -2.118 CFLAR CASP8 and FADD-like apoptosis regulator 2 201689060, 201689134, 201691631 AF009619 2q33-q34 Hs.390736 163

cysteine-type endopeptidase activity

protein binding

proteolysis

anti-apoptosis

induction of apoptosis by extracellular signals

regulation of apoptosis

positive regulation of I-kappaB kinase/NF-kappaB cascade

interspecies interaction between organisms

Apoptosis

204326_x_at 1.274 10.673 4.616 3.245e-04 0.179 0.343 MT1X metallothionein 1X 16 55273882 NM_002450 16q13 Hs.374950 18

copper ion binding

zinc ion binding

response to metal ion

cadmium ion binding

metal ion binding

 
226080_at SSH2 slingshot homolog 2 (Drosophila) 17 -24977090 BE676214 17q11.2 Hs.654754 11

actin binding

protein tyrosine phosphatase activity

cytoplasm

cytoskeleton

protein amino acid dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

hydrolase activity

actin cytoskeleton organization

Regulation of actin cytoskeleton

216512_s_at DCT dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) 13 -93889841 AL139318 13q32 Hs.301865 41

dopachrome isomerase activity

copper ion binding

microsome

cytosol

melanin biosynthetic process from tyrosine

metabolic process

zinc ion binding

epidermis development

membrane

integral to membrane

oxidoreductase activity

isomerase activity

melanosome

metal ion binding

pigmentation during development

cell development

Tyrosine metabolism

Metabolic pathways

Melanogenesis

201938_at 0.317 10.263 2.777 1.395e-02 0.442 -2.838 CDK2AP1 cyclin-dependent kinase 2 associated protein 1 12 -122311492 NM_004642 12q24.31 Hs.719107 15

S phase of mitotic cell cycle

DNA binding

protein binding

nucleus

cytoplasm

DNA-dependent DNA replication

protein amino acid phosphorylation

cell cycle

 
227343_at MYEOV myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas) 11 68818197 AK026148 11q13 Hs.523848 8    
231240_at 0.572 3.524 3.528 2.989e-03 0.300 -1.529 DIO2 deiodinase, iodothyronine, type II 14 -79733621, -79733621 AI038059 14q24.2-q24.3 Hs.202354 61

selenocysteine incorporation

thyroxine 5'-deiodinase activity

thyroid hormone generation

selenium binding

membrane

integral to membrane

thyroid hormone catabolic process

hormone biosynthetic process

oxidation reduction

 
208266_at C8orf17 chromosome 8 open reading frame 17 8   NM_020237 8q24.3 Hs.283098 2

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

microsome

membrane

 
240230_s_at LOC642826 hypothetical LOC642826 10 -46662697, 47805861 AW000942 10q11.22 Hs.463017 Hs.647204 Hs.711074 Hs.711898 Hs.718802 2    
223790_at KATNAL1 katanin p60 subunit A-like 1 13 -29674766, -29674766 BC000612 13q12.3 Hs.243596 7

nucleotide binding

ATP binding

microtubule

microtubule-severing ATPase activity

hydrolase activity

nucleoside-triphosphatase activity

 
1554217_a_at 0.466 2.834 2.925 1.034e-02 0.418 -2.584 CCDC132 coiled-coil domain containing 132 7 92699588, 92699588 BC017888 7q21.3 Hs.222282 5    
235602_at TP53INP1 tumor protein p53 inducible nuclear protein 1 8 -96007376 AI422387 8q22 Hs.492261 16

nucleus

apoptosis

 
225398_at RPUSD4 RNA pseudouridylate synthase domain containing 4 11 -125577199 AL580514 11q24.2 Hs.150458 5

pseudouridine synthesis

RNA binding

pseudouridine synthase activity

 
220937_s_at 0.509 6.770 3.064 7.775e-03 0.381 -2.342 ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 9 -129709985 NM_014403 9q34 Hs.3972 Hs.709827 13

soluble fraction

nucleus

Golgi apparatus

protein amino acid glycosylation

glycolipid metabolic process

membrane

integral to membrane

integral to Golgi membrane

(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity

Glycosphingolipid biosynthesis - ganglio series

Metabolic pathways

203403_s_at RNF6 ring finger protein (C3H2C3 type) 6 13 -25684904, -25684904, -25684904 NM_005977 13q12.2 Hs.136885 7

protein binding

cellular_component

biological_process

zinc ion binding

metal ion binding

 
215979_s_at SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 13 -28981551 AK022999 13q12-q14 Hs.14846 23

receptor activity

integral to plasma membrane

transport

amino acid transport

amino acid transmembrane transporter activity

arginine transmembrane transporter activity

arginine transport

membrane

 
221532_s_at WDR61 WD repeat domain 61 15 -76362632 AF309553 15q25.1 Hs.513055 6  

RNA degradation

205738_s_at FABP3 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) 1 -31610686 NM_004102 1p33-p32 Hs.657242 35

transporter activity

cytoplasm

phosphatidylcholine biosynthetic process

transport

negative regulation of cell proliferation

lipid binding

PPAR signaling pathway

244881_at 0.328 5.916 2.744 1.493e-02 0.453 -2.895 LMLN leishmanolysin-like (metallopeptidase M8 family) 3 199171467 AA629059 3q29 Hs.518540 2

metalloendopeptidase activity

cytoplasm

proteolysis

cell cycle

mitosis

cell adhesion

peptidase activity

zinc ion binding

membrane

metal ion binding

cell division

 
213503_x_at 1.052 9.477 4.119 8.858e-04 0.219 -0.498 ANXA2 annexin A2 15 -58426642, -58426641 BE908217 15q21-q22 Hs.511605 137

skeletal system development

angiogenesis

phospholipase inhibitor activity

calcium ion binding

calcium-dependent phospholipid binding

phosphatidylinositol-4,5-bisphosphate binding

extracellular region

basement membrane

soluble fraction

cytoplasm

early endosome

cytoskeletal protein binding

collagen fibril organization

sarcolemma

melanosome

fibrinolysis

protein complex

perinuclear region of cytoplasm

 
226736_at 1.721 7.588 2.839 1.232e-02 0.427 -2.733 CHURC1 churchill domain containing 1 14 64450892 BE568660 14q23.3 Hs.325531 5

multicellular organismal development

zinc ion binding

transcription activator activity

positive regulation of transcription

metal ion binding

 
230904_at FSD1L fibronectin type III and SPRY domain containing 1-like 9 107250135, 107250135, 107250145 W42665 9q31 Hs.136901 4

molecular_function

cellular_component

biological_process

 
200866_s_at 0.543 8.333 2.845 1.215e-02 0.426 -2.721 PSAP prosaposin 10 -73246060 M32221 10q21-q22 Hs.523004 Hs.705948 76

extracellular space

lysosome

Golgi apparatus

lipid metabolic process

glycosphingolipid metabolic process

lipid transport

enzyme activator activity

lipid binding

integral to membrane

Lysosome

212232_at FNBP4 formin binding protein 4 11 -47694644 AB023231 11p11.2 Hs.6834 11

protein binding

 
229702_at CSNK1G3 casein kinase 1, gamma 3 5 122875691 BF516404 5q23 Hs.129206 6

nucleotide binding

protein serine/threonine kinase activity

ATP binding

cytoplasm

protein modification process

protein amino acid phosphorylation

signal transduction

Wnt receptor signaling pathway

transferase activity

Hedgehog signaling pathway

209206_at SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) 1 143807763 AV701283 1q21.1 Hs.632438 Hs.715002 13

protein binding

endoplasmic reticulum

ER-Golgi intermediate compartment

Golgi apparatus

ER to Golgi vesicle-mediated transport

protein transport

membrane

integral to membrane

vesicle-mediated transport

melanosome

SNARE interactions in vesicular transport

201375_s_at 0.390 10.090 3.217 5.674e-03 0.356 -2.074 PPP2CB protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform 8 -30762667 NM_004156 8p12 Hs.491440 40

protein phosphatase type 2A complex

chromosome, centromeric region

protein serine/threonine phosphatase activity

iron ion binding

protein binding

nucleus

cytoplasm

spindle

protein amino acid dephosphorylation

regulation of gene expression

hydrolase activity

manganese ion binding

response to hydrogen peroxide

negative regulation of apoptosis

proteasomal ubiquitin-dependent protein catabolic process

response to antibiotic

metal ion binding

Wnt signaling pathway

TGF-beta signaling pathway

Tight junction

Long-term depression

221550_at COX15 COX15 homolog, cytochrome c oxidase assembly protein (yeast) 10 -101458494 BC002382 10q24 Hs.28326 9

catalytic activity

cytochrome-c oxidase activity

mitochondrial respiratory chain

mitochondrial electron transport, cytochrome c to oxygen

protein complex assembly

heme a biosynthetic process

respiratory gaseous exchange

respiratory chain complex IV assembly

membrane

integral to membrane

mitochondrial part

cellular respiration

oxidation reduction

Oxidative phosphorylation

Porphyrin and chlorophyll metabolism

Metabolic pathways

207980_s_at CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 6 -139735089 NM_006079 6q23.3 Hs.82071 21

negative regulation of transcription from RNA polymerase II promoter

nuclear chromatin

response to hypoxia

liver development

transcription factor activity

transcription coactivator activity

transcription corepressor activity

protein binding

nucleus

anti-apoptosis

determination of left/right symmetry

heart development

heart development

positive regulation of specific transcription from RNA polymerase II promoter

positive regulation of cell-cell adhesion

negative regulation of cell migration

positive regulation of transforming growth factor beta receptor signaling pathway

response to fluid shear stress

positive regulation of cell cycle

positive regulation of transcription, DNA-dependent

 
203475_at -0.246 4.197 -2.937 1.009e-02 0.415 -2.563 CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 15 -49287545 NM_000103 15q21.1 Hs.260074 375

membrane fraction

endoplasmic reticulum

steroid biosynthetic process

steroid biosynthetic process

electron carrier activity

membrane

oxygen binding

heme binding

metal ion binding

oxidation reduction

aromatase activity

Androgen and estrogen metabolism

Metabolic pathways

224630_at 0.324 7.942 3.121 6.918e-03 0.370 -2.243 ERLEC1 endoplasmic reticulum lectin 1 2 53867571 AK001913 2p16.2 Hs.438336 Hs.713845 10

protein binding

endoplasmic reticulum

endoplasmic reticulum lumen

 
211317_s_at 0.703 7.298 3.195 5.943e-03 0.357 -2.114 CFLAR CASP8 and FADD-like apoptosis regulator 2 201689060, 201689134, 201691631 AF041461 2q33-q34 Hs.390736 163

cysteine-type endopeptidase activity

protein binding

proteolysis

anti-apoptosis

induction of apoptosis by extracellular signals

regulation of apoptosis

positive regulation of I-kappaB kinase/NF-kappaB cascade

interspecies interaction between organisms

Apoptosis

232941_at TMPRSS6 transmembrane protease, serine 6 22 -35791424 AA609066 22q12.3 Hs.370885 16

angiogenesis

serine-type endopeptidase activity

plasma membrane

proteolysis

intracellular signaling cascade

peptidase activity

integral to membrane

extracellular matrix organization

fibrinolysis

 
207643_s_at 0.268 6.990 2.191 4.440e-02 0.580 -3.806 TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 12 -6308183 NM_001065 12p13.2 Hs.279594 Hs.713833 271

receptor activity

tumor necrosis factor receptor activity

protein binding

extracellular region

plasma membrane

plasma membrane

integral to plasma membrane

prostaglandin metabolic process

apoptosis

signal transduction

cytokine-mediated signaling pathway

positive regulation of I-kappaB kinase/NF-kappaB cascade

interspecies interaction between organisms

membrane raft

positive regulation of transcription from RNA polymerase II promoter

positive regulation of inflammatory response

MAPK signaling pathway

Cytokine-cytokine receptor interaction

Apoptosis

Adipocytokine signaling pathway

Alzheimer's disease

Amyotrophic lateral sclerosis (ALS)

222848_at 0.298 2.939 2.931 1.021e-02 0.417 -2.574 CENPK centromere protein K 5 -64849348 BC005400 5p15.2-q12.3 Hs.529778 9

chromosome, centromeric region

protein binding

nucleus

chromosome

positive regulation of transcription from RNA polymerase II promoter

 
1558533_at KRBA2 KRAB-A domain containing 2 17 -8212697 BC024723 17p13.1 Hs.304604 1

DNA binding

intracellular

regulation of transcription, DNA-dependent

DNA integration

 
205331_s_at REEP2 receptor accessory protein 2 5 137802674 NM_016606 5q31 Hs.416090 10

membrane

integral to membrane

 
218782_s_at 0.338 3.153 2.650 1.801e-02 0.476 -3.054 ATAD2 ATPase family, AAA domain containing 2 8 -124401271 NM_014109 8q24.13 Hs.370834 9

nucleotide binding

transcription factor activity

ATP binding

nucleus

hydrolase activity

nucleoside-triphosphatase activity

ATPase activity, uncoupled

regulation of transcription

 
216840_s_at 0.718 6.806 4.002 1.126e-03 0.229 -0.701 LAMA2 laminin, alpha 2 6 129245978 AK026829 6q22-q23 Hs.200841 40

receptor binding

structural molecule activity

extracellular region

basal lamina

laminin-1 complex

muscle organ development

regulation of cell adhesion

regulation of cell migration

positive regulation of synaptic transmission, cholinergic

sarcolemma

regulation of embryonic development

Focal adhesion

ECM-receptor interaction

Pathways in cancer

Small cell lung cancer

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

201235_s_at BTG2 BTG family, member 2 1 201541286 BG339064 1q32 Hs.519162 45

protein binding

DNA repair

protein amino acid methylation

response to DNA damage stimulus

negative regulation of cell proliferation

anterior/posterior pattern formation

neuron differentiation

negative regulation of apoptosis

regulation of transcription

 
226770_at MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 1 113734997, 113734997 AI692181 1p12-p11.2 Hs.486189 13

nucleotide binding

protein binding

ATP binding

nucleus

plasma membrane

tight junction

cell junction

interspecies interaction between organisms

Tight junction

238177_at SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 5 1254709 AA873542 5p15.33 Hs.481478 10

neurotransmitter:sodium symporter activity

integral to plasma membrane

neurotransmitter transport

neutral amino acid transmembrane transporter activity

symporter activity

neutral amino acid transport

membrane

 
219167_at -0.412 6.961 -2.571 2.112e-02 0.497 -3.188 RASL12 RAS-like, family 12 15 -63132727 NM_016563 15q11.2-q22.33 Hs.27018 3

nucleotide binding

GTP binding

small GTPase mediated signal transduction

 
208503_s_at GATAD1 GATA zinc finger domain containing 1 7 91914700 NM_021167 7q21-q22 Hs.21145 6

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
238560_at -0.380 6.005 -4.104 9.127e-04 0.220 -0.523 CALCOCO2 calcium binding and coiled-coil domain 2 17 44263370 AI684710 17q21.32 Hs.514920 11

protein binding

soluble fraction

nucleus

cytoplasm

Golgi apparatus

cytoskeleton

viral reproduction

response to interferon-gamma

protein homodimerization activity

perinuclear region of cytoplasm

 
222924_at SLMAP sarcolemma associated protein 3 57718213 BF526855 3p21.2-p14.3 Hs.476432 11

smooth endoplasmic reticulum

plasma membrane

integral to plasma membrane

protein folding

muscle contraction

prefoldin complex

unfolded protein binding

 
209368_at 0.755 5.544 3.428 3.672e-03 0.314 -1.704 EPHX2 epoxide hydrolase 2, cytoplasmic 8 27404561 AF233336 8p21-p12 Hs.212088 54

magnesium ion binding

prostaglandin production during acute inflammatory response

4-nitrophenylphosphatase activity

epoxide hydrolase activity

soluble fraction

cytoplasm

peroxisome

cytosol

oxygen and reactive oxygen species metabolic process

xenobiotic metabolic process

cellular calcium ion homeostasis

inflammatory response

metabolic process

response to toxin

hydrolase activity

drug metabolic process

sensory perception of pain

aromatic compound catabolic process

protein homodimerization activity

linoleic acid metabolic process

positive regulation of blood pressure

positive regulation of vasodilation

Arachidonic acid metabolism

Tetrachloroethene degradation

Metabolic pathways

1561041_at TNRC6C trinucleotide repeat containing 6C 17 73511912 BM459591 17q25.3 Hs.569831 Hs.584945 10

nucleotide binding

RNA binding

regulation of translation

gene silencing by RNA

 
221747_at 0.429 7.501 3.380 4.052e-03 0.323 -1.788 TNS1 tensin 1 2 -218372756 AL046979 2q35-q36 Hs.471381 16

actin binding

protein binding

cytoplasm

cytoskeleton

focal adhesion

cell junction

 
210672_s_at 0.324 6.099 2.894 1.100e-02 0.424 -2.637 C16orf35 chromosome 16 open reading frame 35 16 -75803, -75803 BC004185 16p13.3 Hs.19699 6

molecular_function

cellular_component

biological_process

 
217077_s_at GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 9 -100090186 AF095723 9q22.1-q22.3 Hs.198612 27

receptor activity

G-protein coupled receptor activity

GABA-B receptor activity

protein binding

cytoplasm

plasma membrane

integral to plasma membrane

signal transduction

negative regulation of adenylate cyclase activity

gamma-aminobutyric acid signaling pathway

synaptic transmission

cell junction

neuron projection

synapse

postsynaptic membrane

Neuroactive ligand-receptor interaction

229689_s_at DLG5 discs, large homolog 5 (Drosophila) 10 -79220554 AV721789 10q23 Hs.652690 49

protein binding

intracellular

cytoplasm

plasma membrane

cell-cell adherens junction

intracellular signaling cascade

negative regulation of cell proliferation

cell-cell adhesion

cell junction

receptor signaling complex scaffold activity

regulation of apoptosis

 
228433_at 0.319 5.286 3.022 8.477e-03 0.388 -2.416 NFYA nuclear transcription factor Y, alpha 6 41148684 AU157605 6p21.3 Hs.10441 55

transcription factor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

transcription from RNA polymerase II promoter

CCAAT-binding factor complex

Antigen processing and presentation

211060_x_at 0.310 8.053 2.717 1.574e-02 0.459 -2.940 GPAA1 glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) 8 145209511 BC006383 8q24.3 Hs.627962 16

GPI-anchor transamidase activity

protein binding

endoplasmic reticulum

protein complex assembly

protein retention in ER lumen

tubulin binding

membrane

integral to membrane

attachment of GPI anchor to protein

attachment of GPI anchor to protein

attachment of GPI anchor to protein

GPI anchor binding

GPI-anchor transamidase complex

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

Metabolic pathways

236814_at MDM4 Mdm4 p53 binding protein homolog (mouse) 1 202752133 AA745971 1q32 Hs.497492 68

negative regulation of transcription from RNA polymerase II promoter

protein binding

intracellular

nucleus

protein complex assembly

apoptosis

zinc ion binding

negative regulation of cell proliferation

negative regulation of protein catabolic process

G0 to G1 transition

metal ion binding

protein stabilization

p53 signaling pathway

203430_at 0.249 10.424 2.133 4.964e-02 0.591 -3.898 HEBP2 heme binding protein 2 6 138767028 NM_014320 6q24 Hs.486589 8

cytoplasm

 
231899_at ZC3H12C zinc finger CCCH-type containing 12C 11 109469296 AB051513 11q22.3 Hs.376289 3

magnesium ion binding

endonuclease activity

zinc ion binding

hydrolase activity

 
1558924_s_at 1.382 6.486 4.185 7.743e-04 0.211 -0.385 CLIP1 CAP-GLY domain containing linker protein 1 12 -121321933 BF673049 12q24.3 Hs.524809 37

kinetochore

nucleic acid binding

protein binding

cytoplasm

endosome

microtubule

intermediate filament

mitosis

microtubule binding

zinc ion binding

protein homodimerization activity

metal ion binding

 
1554553_s_at YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 19 -43486039, -43486039, -43486039 BC014974 19q13.2 Hs.280741 Hs.631544 4

membrane

integral to membrane

 
201027_s_at 0.296 7.408 2.198 4.383e-02 0.578 -3.796 EIF5B eukaryotic translation initiation factor 5B 2 99320265 NM_015904 2q11.2 Hs.158688 15

nucleotide binding

translation initiation factor activity

translation initiation factor activity

GTPase activity

protein binding

GTP binding

cytoplasm

translation

regulation of translational initiation

regulation of translational initiation

 
232913_at TMED8 transmembrane emp24 protein transport domain containing 8 14 -76877866 AC007954 14q24.3 Hs.200413 Hs.26403 6    
227357_at MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3 X -30755479 BF593914 Xp21.2 Hs.188256 10

protein binding

intracellular

zinc ion binding

metal ion binding

 
225534_at C8orf40 chromosome 8 open reading frame 40 8 42515454, 42515874, 42515921, 42516095 AV711345 8p11.21 Hs.655320 4

membrane

integral to membrane

 
231647_s_at FCRL5 Fc receptor-like 5 1 -155749790 AW241983 1q21 Hs.415950 15

receptor activity

plasma membrane

integral to membrane

 
202023_at EFNA1 ephrin-A1 1 153366972 NM_004428 1q21-q22 Hs.516664 44

plasma membrane

integral to plasma membrane

cell-cell signaling

anchored to membrane

ephrin receptor binding

Axon guidance

225537_at TRAPPC6B trafficking protein particle complex 6B 14 -38686765 AA936745 14q21.1 Hs.13303 5

endoplasmic reticulum

Golgi apparatus

vesicle-mediated transport

 
213489_at 0.504 7.624 2.372 3.128e-02 0.543 -3.516 MAPRE2 microtubule-associated protein, RP/EB family, member 2 18 30810889, 30812205, 30875321 BE671156 18q12.1-q12.2 Hs.532824 27

cytoplasm

microtubule

cell cycle

mitosis

signal transduction

microtubule binding

cell proliferation

cell division

 
226261_at 0.389 3.504 3.076 7.588e-03 0.378 -2.322 ZNRF2 zinc and ring finger 2 7 30290447 AI831561 7p14.3 Hs.487869 4

protein binding

lysosome

endosome

plasma membrane

zinc ion binding

ligase activity

modification-dependent protein catabolic process

cell junction

synapse

metal ion binding

 
200722_s_at CAPRIN1 cell cycle associated protein 1 11 34029805, 34029805 BG258784 11p13 Hs.471818 10

protein binding

cytoplasm

cytosol

integral to plasma membrane

dendrite

cell projection

 
204378_at BCAS1 breast carcinoma amplified sequence 1 20 -51993485 NM_003657 20q13.2 Hs.400556 12

protein binding

cytoplasm

 
203384_s_at GOLGA1 golgi autoantigen, golgin subfamily a, 1 9 -126680394 NM_002077 9q33.3 Hs.133469 Hs.59504 11

Golgi apparatus

membrane

 
227933_at LINGO1 leucine rich repeat and Ig domain containing 1 15 -75692423 AI193252 15q24.3 Hs.656765 14    
233470_at PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 11 -18706050 U27831 11p15.1 Hs.79092 10

protein tyrosine phosphatase activity

protein amino acid dephosphorylation

integral to membrane

hydrolase activity

MAPK signaling pathway

244783_at YAF2 YY1 associated factor 2 12 -40837173 R56794 12q12 Hs.708084 9

transcription coactivator activity

transcription corepressor activity

protein binding

intracellular

nucleus

zinc ion binding

negative regulation of transcription

positive regulation of transcription

metal ion binding

 
212878_s_at 0.496 7.919 3.094 7.313e-03 0.376 -2.290 KLC1 kinesin light chain 1 14 103165277, 103165277 AA284075 14q32.3 Hs.20107 Hs.657678 31

microtubule motor activity

protein binding

cytoplasm

cytosol

kinesin complex

microtubule

axon cargo transport

axon

cytoplasmic vesicle

ciliary rootlet

membrane-bounded organelle

 
205710_at LRP2 low density lipoprotein-related protein 2 2 -169691864 NM_004525 2q24-q31 Hs.657729 65

receptor activity

calcium ion binding

protein binding

membrane fraction

lysosome

endosome

endoplasmic reticulum

Golgi apparatus

brush border

coated pit

protein amino acid glycosylation

lipid metabolic process

vitamin metabolic process

receptor-mediated endocytosis

cell proliferation

membrane

integral to membrane

apical plasma membrane

SH3 domain binding

endocytic vesicle

forebrain development

Hedgehog signaling pathway

214787_at DENND4A DENN/MADD domain containing 4A 15 -63740012 BE268538 15q22.31 Hs.654567 8

DNA binding

protein binding

nucleus

regulation of transcription, DNA-dependent

 
208679_s_at ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 2 218790118, 218790364 AF279893 2q36.1 Hs.529303 23

actin binding

structural constituent of cytoskeleton

protein binding

cytoplasm

Golgi apparatus

Arp2/3 protein complex

focal adhesion

cell motion

positive regulation of actin filament polymerization

cell leading edge

cell projection

Fc gamma R-mediated phagocytosis

Regulation of actin cytoskeleton

242146_at SNRPA1 small nuclear ribonucleoprotein polypeptide A' 15 -99639237 AA872471 15q26.3 Hs.528763 22

nuclear mRNA splicing, via spliceosome

nuclear mRNA splicing, via spliceosome

RNA binding

protein binding

nucleus

spliceosomal complex

U2 snRNP

RNA splicing

 
213116_at 0.371 5.404 2.730 1.535e-02 0.457 -2.919 NEK3 NIMA (never in mitosis gene a)-related kinase 3 13 -51604780, -51604779, -51604779 AI191920 13q14.13 Hs.409989 12

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

protein amino acid phosphorylation

cell cycle

mitosis

transferase activity

cell division

 
222668_at 1.150 4.264 4.284 6.335e-04 0.211 -0.216 KCTD15 potassium channel tetramerisation domain containing 15 19 38979590 W73820 19q13.11 Hs.221873 Hs.606506 12

voltage-gated potassium channel activity

protein binding

potassium ion transport

voltage-gated potassium channel complex

membrane

 
223065_s_at 0.367 7.615 2.494 2.459e-02 0.513 -3.316 STARD3NL STARD3 N-terminal like 7 38184457 BC003074 7p14-p13 Hs.309753 13

endosome

membrane

integral to membrane

 
207956_x_at PDS5B PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 13 32058591 NM_015928 13q12.3 Hs.716441 15

chromatin

DNA binding

ATP binding

nucleus

cell cycle

mitotic sister chromatid cohesion

mitosis

negative regulation of cell proliferation

identical protein binding

cell division

 
222991_s_at UBQLN1 ubiquilin 1 9 -85464697 AL136643 9q21.2-q21.3 9q22 Hs.9589 46

nucleus

cytoplasm

cytosol

kinase binding

protein complex

perinuclear region of cytoplasm

 
232704_s_at 0.454 6.347 2.983 9.176e-03 0.400 -2.483 LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 3 -37069120 AK025207 3p22.2 Hs.719246 7

protein binding

cellular_component

biological_process

Wnt receptor signaling pathway

LRR domain binding

 
1568834_s_at CCDC90B coiled-coil domain containing 90B 11 -82650149 BC017771 11q14.1 Hs.368866 7

mitochondrion

membrane

integral to membrane

 
1560006_a_at LOC646762 hypothetical LOC646762 7 -29652063 BG501482 7p14.3 Hs.30579 2    
211063_s_at NCK1 NCK adaptor protein 1 3 138063762 BC006403 3q21 Hs.477693 110

receptor binding

cytoplasm

endoplasmic reticulum

regulation of translation

actin filament organization

signal complex assembly

cytoskeletal adaptor activity

vesicle membrane

cell migration

protein domain specific binding

lamellipodium assembly

receptor signaling complex scaffold activity

positive regulation of actin filament polymerization

positive regulation of T cell proliferation

T cell activation

ErbB signaling pathway

Axon guidance

T cell receptor signaling pathway

Pathogenic Escherichia coli infection - EHEC

216401_x_at LOC652493 similar to Ig kappa chain V-I region HK102 precursor Un   AJ408433          
217550_at ATF6 activating transcription factor 6 1 160002707 AA576497 1q22-q23 Hs.492740 43

transcription factor activity

RNA polymerase II transcription factor activity

transcription coactivator activity

nucleus

nuclear envelope

nucleoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

regulation of transcription from RNA polymerase II promoter

protein folding

response to unfolded protein

positive regulation of gene-specific transcription involved in unfolded protein response

signal transduction

membrane

integral to membrane

sequence-specific DNA binding

protein dimerization activity

Alzheimer's disease

239654_at CHD9 chromodomain helicase DNA binding protein 9 16 51646445 T98846 16q12.2 Hs.59159 Hs.622347 10

nucleotide binding

chromatin

DNA binding

chromatin binding

helicase activity

protein binding

ATP binding

nucleus

cytoplasm

chromatin assembly or disassembly

chromatin modification

hydrolase activity

regulation of transcription

 
236600_at SPG20 spastic paraplegia 20 (Troyer syndrome) 13 -35773776, -35773776, -35773776 AI651603 13q13.3 Hs.440414 19

cell death

 
225009_at CMTM4 CKLF-like MARVEL transmembrane domain containing 4 16 -65206153 AA191708 16q21-q22.1 Hs.643961 3

cytokine activity

extracellular space

chemotaxis

membrane

integral to membrane

 
201590_x_at 1.079 9.579 4.213 7.320e-04 0.211 -0.338 ANXA2 annexin A2 15 -58426642, -58426641 NM_004039 15q21-q22 Hs.511605 137

skeletal system development

angiogenesis

phospholipase inhibitor activity

calcium ion binding

calcium-dependent phospholipid binding

phosphatidylinositol-4,5-bisphosphate binding

extracellular region

basement membrane

soluble fraction

cytoplasm

early endosome

cytoskeletal protein binding

collagen fibril organization

sarcolemma

melanosome

fibrinolysis

protein complex

perinuclear region of cytoplasm

 
213427_at RPP40 ribonuclease P/MRP 40kDa subunit 6 -4940278 NM_006638 6p25.1 Hs.511756 4

ribonuclease P activity

protein binding

nucleus

nucleolar ribonuclease P complex

nucleolus

tRNA processing

hydrolase activity

 
225244_at SNAP47 synaptosomal-associated protein, 47kDa 1 225989319 AA019893 1q42.13 Hs.325081 3

cytoplasm

membrane

perinuclear region of cytoplasm

SNARE interactions in vesicular transport

203411_s_at 0.417 7.886 4.147 8.367e-04 0.216 -0.450 LMNA lamin A/C 1 154351084, 154351084 NM_005572 1q21.2-q21.3 Hs.594444 279

structural molecule activity

protein binding

nucleus

cytoplasm

intermediate filament

plasma membrane

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

1559946_s_at 0.466 8.615 2.858 1.185e-02 0.426 -2.700 RUVBL2 RuvB-like 2 (E. coli) 19 54188967 AI860098 19q13.3 Hs.515846 46

nucleotide binding

damaged DNA binding

ATP-dependent DNA helicase activity

ATP binding

intracellular

nucleus

nucleoplasm

cytoplasm

DNA repair

DNA recombination

protein folding

membrane

nuclear matrix

chromatin modification

hydrolase activity

ATPase activity

NuA4 histone acetyltransferase complex

regulation of growth

identical protein binding

histone H4 acetylation

histone H2A acetylation

regulation of transcription

unfolded protein binding

 
204366_s_at GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa 2 -27402224 NM_001521 2p23.3 Hs.75782 18

transcription factor TFIIIC complex

DNA binding

RNA polymerase III transcription factor activity

protein binding

nucleus

mitochondrion

peroxisome

transcription, DNA-dependent

oxygen and reactive oxygen species metabolic process

5S class rRNA transcription

tRNA transcription from RNA polymerase III promoter

 
203405_at PSMG1 proteasome (prosome, macropain) assembly chaperone 1 21 -39469253 NM_003720 21q22.3 Hs.473838 12

protein binding

cytoplasm

endoplasmic reticulum

proteasome assembly

 
228506_at NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 10 -123706592 AA009947 10q26.13 Hs.258798 8    
204392_at CAMK1 calcium/calmodulin-dependent protein kinase I 3 -9774030 NM_003656 3p25.3 Hs.434875 31

nucleotide binding

calmodulin-dependent protein kinase activity

calmodulin binding

ATP binding

nucleus

cytoplasm

protein amino acid phosphorylation

nucleocytoplasmic transport

signal transduction

multicellular organismal development

nervous system development

transferase activity

cell differentiation

 
227731_at CNBP CCHC-type zinc finger, nucleic acid binding protein 3 -130369347 BF063728 3q21 Hs.518249 24

transcription factor activity

protein binding

cytoplasm

endoplasmic reticulum

regulation of transcription, DNA-dependent

cholesterol biosynthetic process

zinc ion binding

metal ion binding

 
225049_at 0.415 9.138 2.939 1.004e-02 0.414 -2.559 BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2 10 -102023702, -102023702 BF382281 10q24.31 Hs.34906 12

gamma-tubulin complex

centrosome

BLOC-1 complex

melanosome organization

identical protein binding

regulation of apoptosis

gamma-tubulin binding

platelet dense granule organization

 
201565_s_at ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2 8739563 NM_002166 2p25 Hs.180919 76

negative regulation of transcription from RNA polymerase II promoter

protein binding

nucleus

nucleus

cytoplasm

multicellular organismal development

heart development

negative regulation of transcription

transcription repressor activity

enucleate erythrocyte differentiation

negative regulation of transcription factor activity

positive regulation of macrophage differentiation

TGF-beta signaling pathway

209107_x_at 0.254 7.573 2.295 3.638e-02 0.559 -3.642 NCOA1 nuclear receptor coactivator 1 2 24660849 U19179 2p23 Hs.596314 123

DNA binding

chromatin binding

transcription coactivator activity

histone acetyltransferase activity

signal transducer activity

nucleus

signal transduction

acyltransferase activity

transferase activity

androgen receptor signaling pathway

transcription regulator activity

nuclear hormone receptor binding

positive regulation of transcription from RNA polymerase II promoter

protein N-terminus binding

androgen receptor binding

 
215377_at CTBP2 C-terminal binding protein 2 10 -126666407, -126666407, -126666407 AK024129 10q26.13 Hs.501345 32

nucleus

negative regulation of cell proliferation

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

viral genome replication

cell junction

synapse

cofactor binding

NAD or NADH binding

oxidation reduction

Wnt signaling pathway

Notch signaling pathway

Pathways in cancer

Chronic myeloid leukemia

206284_x_at CLTB clathrin, light chain (Lcb) 5 -175752061 NM_001834 4q2-q3 5q35 Hs.484241 17

structural molecule activity

calcium ion binding

protein binding

intracellular protein transport

membrane

vesicle-mediated transport

clathrin coat of trans-Golgi network vesicle

clathrin coat of coated pit

cytoplasmic vesicle

Lysosome

Endocytosis

Huntington's disease

230049_at -0.272 4.975 -3.223 5.601e-03 0.354 -2.063 TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 11 62295450 AW303570 11q12.3 Hs.714400 13

histone deacetylase complex

DNA binding

RNA polymerase II transcription factor activity

transcription coactivator activity

histone acetyltransferase activity

protein binding

nucleus

chromatin remodeling

transcription initiation

regulation of transcription from RNA polymerase II promoter

transcription initiation factor activity

STAGA complex

histone H3 acetylation

regulation of transcription factor activity

Basal transcription factors

221535_at LSG1 large subunit GTPase 1 homolog (S. cerevisiae) 3 -195842806 AL136897 3q29 Hs.518505 12

nucleotide binding

GTP binding

intracellular

nucleus

cytoplasm

endoplasmic reticulum

Cajal body

protein transport

hydrolase activity

nuclear export

 
219500_at CLCF1 cardiotrophin-like cytokine factor 1 11 -66888214 NM_013246 11q13.3 Hs.502977 13

cytokine activity

extracellular region

extracellular space

JAK-STAT cascade

growth factor activity

cytokine-mediated signaling pathway

B cell differentiation

positive regulation of tyrosine phosphorylation of Stat3 protein

negative regulation of apoptosis

Cytokine-cytokine receptor interaction

Jak-STAT signaling pathway

224842_at SMG1 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) 16 -18723676 AK025794 16p12.3 Hs.460179 Hs.552700 23

nucleotide binding

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

cytoplasm

cytoplasm

DNA repair

mRNA export from nucleus

response to DNA damage stimulus

transferase activity

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

manganese ion binding

protein amino acid autophosphorylation

phosphoinositide phosphorylation

metal ion binding

 
227091_at -0.440 4.776 -4.009 1.110e-03 0.228 -0.689 CCDC146 coiled-coil domain containing 146 7 76589869 AB040938 7q11.23 Hs.113940 4    
223046_at EGLN1 egl nine homolog 1 (C. elegans) 1 -229566120 AL117352 1q42.1 Hs.444450 Hs.710300 42

response to hypoxia

embryonic placenta development

iron ion binding

protein binding

cytosol

heart development

zinc ion binding

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

L-ascorbic acid binding

peptidyl-proline dioxygenase activity

oxygen homeostasis

negative regulation of transcription factor activity

metal ion binding

oxidation reduction

Pathways in cancer

Renal cell carcinoma

208579_x_at 0.635 5.642 4.345 5.600e-04 0.210 -0.113 H2BFS H2B histone family, member S 21   NM_017445 21q22.3 Hs.473961 17

nucleosome

DNA binding

nucleus

chromosome

nucleosome assembly

defense response to bacterium

 
219083_at 0.397 7.144 2.841 1.226e-02 0.427 -2.729 SHQ1 SHQ1 homolog (S. cerevisiae) 3 -72881117 NM_018130 3p13 Hs.606584 2    
201199_s_at 0.417 9.140 3.103 7.174e-03 0.374 -2.274 PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 2 231629852 NM_002807 2q37.1 Hs.3887 43

proteasome complex

protein binding

cytosol

proteasome regulatory particle

enzyme regulator activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

203688_at 0.445 5.583 3.108 7.098e-03 0.372 -2.265 PKD2 polycystic kidney disease 2 (autosomal dominant) 4 89147843 NM_000297 4q21-q23 Hs.181272 82

kidney development

embryonic placenta development

polycystin complex

receptor binding

ion channel activity

voltage-gated chloride channel activity

voltage-gated sodium channel activity

potassium channel activity

calcium ion binding

plasma membrane

microtubule basal body

cation transport

calcium ion transport

cellular calcium ion homeostasis

cell cycle arrest

cell-matrix adhesion

JAK-STAT cascade

determination of left/right symmetry

heart development

protein C-terminus binding

cytoskeletal protein binding

organ morphogenesis

channel activity

actin cytoskeleton

integral to membrane

regulation of cAMP metabolic process

motile primary cilium

nonmotile primary cilium

detection of mechanical stimulus

ATPase binding

release of sequestered calcium ion into cytosol

negative regulation of ryanodine-sensitive calcium-release channel activity

 
210156_s_at PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 6 150112523 D25547 6q24-q25 Hs.279257 25

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

cellular_component

cytoplasm

endoplasmic reticulum

protein modification process

protein amino acid methylation

methyltransferase activity

transferase activity

protein repair

identical protein binding

 
207543_s_at P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 10 -74436987 NM_000917 10q21.3-q23.1 Hs.500047 Hs.593005 19

procollagen-proline 4-dioxygenase activity

binding

iron ion binding

mitochondrion

endoplasmic reticulum

endoplasmic reticulum lumen

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

L-ascorbic acid binding

metal ion binding

oxidation reduction

Arginine and proline metabolism

Metabolic pathways

211566_x_at 0.480 7.654 3.966 1.212e-03 0.234 -0.763 BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 2 27966985, 27967060 U19178 2p23.2 Hs.258314 20

nuclear ubiquitin ligase complex

peroxisome targeting sequence binding

tumor necrosis factor receptor binding

protein binding

nucleus

cytoplasm

double-strand break repair

apoptosis

response to DNA damage stimulus

signal transduction

response to ionizing radiation

chromatin modification

G2/M transition DNA damage checkpoint

polyubiquitin binding

positive regulation of DNA repair

positive regulation of anti-apoptosis

BRCA1-A complex

BRISC complex

 
232500_at C20orf74 chromosome 20 open reading frame 74 20 -20321410 AL121896 20p11.22 Hs.472285 4

GTPase activator activity

intracellular

cytoplasm

regulation of small GTPase mediated signal transduction

 
200847_s_at TMEM66 transmembrane protein 66 8 -30040172 NM_016127 8p12 Hs.521487 10

membrane

integral to membrane

 
233589_x_at C9orf167 chromosome 9 open reading frame 167 9 139292100 AK000392 9q34.3 Hs.495541 1

nucleotide binding

ATP binding

endoplasmic reticulum

membrane

integral to membrane

nucleoside-triphosphatase activity

chaperone mediated protein folding requiring cofactor

 
227027_at 0.481 6.038 2.398 2.972e-02 0.536 -3.474 GFPT1 glutamine-fructose-6-phosphate transaminase 1 2 -69400408 AI268315 2p13 Hs.580300 29

glutamine-fructose-6-phosphate transaminase (isomerizing) activity

sugar binding

cytoplasm

fructose 6-phosphate metabolic process

energy reserve metabolic process

glutamine metabolic process

metabolic process

carbohydrate biosynthetic process

transferase activity

Alanine, aspartate and glutamate metabolism

Amino sugar and nucleotide sugar metabolism

Metabolic pathways

201675_at -0.487 10.658 -3.058 7.876e-03 0.383 -2.353 AKAP1 A kinase (PRKA) anchor protein 1 17 52517551 NM_003488 17q21-q23 Hs.463506 27

RNA binding

protein binding

cytoplasm

mitochondrion

mitochondrial outer membrane

membrane

integral to membrane

 
238840_at LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 2 238200962, 238265545, 238265545 AW082668 2q37.3 Hs.471779 16

DNA binding

double-stranded RNA binding

protein binding

nucleus

cytoplasm

cytoskeleton

regulation of transcription from RNA polymerase II promoter

negative regulation of transcription

transcription repressor activity

 
204026_s_at 0.439 4.881 3.407 3.834e-03 0.319 -1.741 ZWINT ZW10 interactor 10 -57787204 NM_007057 10q21-q22 Hs.591363 17

mitotic sister chromatid segregation

condensed chromosome kinetochore

nucleus

cell cycle

spindle organization

mitotic cell cycle checkpoint

protein N-terminus binding

phosphoinositide-mediated signaling

cell division

establishment of localization in cell

 
218177_at 0.567 5.945 3.053 7.945e-03 0.384 -2.361 CHMP1B chromatin modifying protein 1B 18 11841388 AA293502 18p11.21 Hs.656244 16

cytoplasm

endosome

cytosol

cell cycle

protein transport

membrane

protein domain specific binding

cell division

Endocytosis

205111_s_at 0.831 4.732 3.408 3.828e-03 0.319 -1.739 PLCE1 phospholipase C, epsilon 1 10 95743735 NM_016341 10q23 Hs.655033 35

Golgi membrane

activation of MAPK activity

regulation of cell growth

phosphoinositide phospholipase C activity

receptor signaling protein activity

guanyl-nucleotide exchange factor activity

calcium ion binding

intracellular

membrane fraction

cytoplasm

Golgi apparatus

cytosol

plasma membrane

phospholipid metabolic process

diacylglycerol biosynthetic process

regulation of smooth muscle contraction

cytoskeleton organization

epidermal growth factor receptor signaling pathway

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

elevation of cytosolic calcium ion concentration

activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway

heart development

regulation of G-protein coupled receptor protein signaling pathway

cell proliferation

lipid catabolic process

hydrolase activity

Ras GTPase binding

calcium-mediated signaling

calcium-mediated signaling

enzyme binding

glomerulus development

regulation of protein kinase activity

regulation of Ras protein signal transduction

inositol phosphate-mediated signaling

Inositol phosphate metabolism

Metabolic pathways

Calcium signaling pathway

Phosphatidylinositol signaling system

237257_at -0.371 7.260 -2.655 1.784e-02 0.475 -3.046 RAB4B RAB4B, member RAS oncogene family 19 45976010 AI668580 19q13.2 Hs.631539 5

nucleotide binding

GTPase activity

GTP binding

intracellular

plasma membrane

small GTPase mediated signal transduction

protein transport

vesicle-mediated transport

 
216942_s_at 0.343 5.244 2.390 3.021e-02 0.540 -3.487 CD58 CD58 molecule 1 -116862845, -116858679 D28586 1p13 Hs.34341 38

protein binding

plasma membrane

integral to plasma membrane

cell-cell adhesion

anchored to membrane

Cell adhesion molecules (CAMs)

229969_at SEC63 SEC63 homolog (S. cerevisiae) 6 -108295652 AV723931 6q21 Hs.26904 14

receptor activity

endoplasmic reticulum

protein folding

protein targeting to membrane

protein transport

membrane

integral to membrane

heat shock protein binding

unfolded protein binding

 
209217_s_at WDR45 WD repeat domain 45 X -48819035, -48819035 BC000464 Xp11.23 Hs.632807 8    
241959_at ANAPC10 anaphase promoting complex subunit 10 4 -146135759 AW025455 4q31 Hs.480876 21

G2/M transition of mitotic cell cycle

mitotic anaphase

ubiquitin-protein ligase activity

protein binding

nucleoplasm

anaphase-promoting complex

cytosol

ubiquitin-dependent protein catabolic process

cell cycle

regulation of mitotic metaphase/anaphase transition

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

cell division

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Cell cycle

Ubiquitin mediated proteolysis

224720_at MIB1 mindbomb homolog 1 (Drosophila) 18 17575542 AW243097 18q11.2 Hs.140903 Hs.658808 15

blood vessel development

in utero embryonic development

somitogenesis

neural tube formation

heart looping

ubiquitin-protein ligase activity

protein binding

cytoplasm

plasma membrane

Notch signaling pathway

heart development

zinc ion binding

protein ubiquitination

ligase activity

modification-dependent protein catabolic process

cytoplasmic vesicle

negative regulation of neuron differentiation

positive regulation of endocytosis

metal ion binding

 
228845_at 0.255 6.076 2.842 1.222e-02 0.427 -2.726 PLBD2 phospholipase B domain containing 2 12 112280753 AW451356 12q24.13 Hs.115896 4

lipid catabolic process

hydrolase activity

lysosomal lumen

 
201449_at TIA1 TIA1 cytotoxic granule-associated RNA binding protein 2 -70290079 AL567227 2p13 Hs.413123 34

nucleotide binding

RNA binding

protein binding

apoptosis

induction of apoptosis

poly(A) RNA binding

 
226470_at GGT7 gamma-glutamyltransferase 7 20 -32896183 AL049709 20q11.22 Hs.433738 9

gamma-glutamyltransferase activity

glutathione biosynthetic process

acyltransferase activity

membrane

integral to membrane

transferase activity

Taurine and hypotaurine metabolism

Selenoamino acid metabolism

Cyanoamino acid metabolism

Glutathione metabolism

Arachidonic acid metabolism

Metabolic pathways

219377_at FAM59A family with sequence similarity 59, member A 18 -28101474 NM_022751 18q12.1 Hs.444314 7    
227511_at SAMD4B sterile alpha motif domain containing 4B 19 44524947 BE963280 19q13.2 Hs.612332 8

protein binding

 
231849_at 0.663 3.849 2.545 2.226e-02 0.500 -3.232 KRT80 keratin 80 12 -50849046 AL162069 12q13.13 Hs.140978 3

structural molecule activity

keratin filament

 
205309_at SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 1 28134090, 28134090 NM_014474 1p35.3 Hs.123659 3

sphingomyelin phosphodiesterase activity

extracellular region

extracellular space

sphingomyelin catabolic process

metabolic process

hydrolase activity, acting on glycosyl bonds

 
201471_s_at 0.264 9.615 2.190 4.452e-02 0.580 -3.809 SQSTM1 sequestosome 1 5 179165993, 179166608, 179180447 NM_003900 5q35 Hs.437277 100

protein kinase C binding

protein binding

nucleus

cytoplasm

late endosome

cytosol

cytosol

ubiquitin-dependent protein catabolic process

apoptosis

response to stress

immune response

intracellular signaling cascade

protein localization

zinc ion binding

endosome transport

cell differentiation

receptor tyrosine kinase binding

SH2 domain binding

SH2 domain binding

regulation of I-kappaB kinase/NF-kappaB cascade

regulation of I-kappaB kinase/NF-kappaB cascade

ubiquitin binding

ubiquitin binding

positive regulation of transcription from RNA polymerase II promoter

metal ion binding

 
1553874_a_at -0.263 4.069 -2.519 2.344e-02 0.507 -3.275 ZSCAN10 zinc finger and SCAN domain containing 10 16 -3078895 NM_032805 16p13.3 Hs.334515 4

transcription factor activity

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
206283_s_at TAL1 T-cell acute lymphocytic leukemia 1 1 -47454549 NM_003189 1p32 Hs.705618 Hs.709194 65

DNA binding

protein binding

nucleus

multicellular organismal development

cell proliferation

cell differentiation

transcription regulator activity

regulation of transcription

 
1567250_at OR10A3 olfactory receptor, family 10, subfamily A, member 3 11 -7916698 X64986 11p15.4 Hs.381322 5

receptor activity

olfactory receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

sensory perception of smell

integral to membrane

response to stimulus

Olfactory transduction

224616_at 0.309 9.374 3.063 7.793e-03 0.381 -2.344 DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 16 -65312299 BG110975 16q22.1 Hs.369068 10

nucleotide binding

motor activity

ATP binding

cytoplasmic dynein complex

microtubule

 
1555942_a_at LOC642587 NPC-A-5 1 207668790 AK091113 1q32.2 Hs.510543 2    
205902_at KCNN3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 1 -152946536, -152946536 AJ251016 1q21.3 Hs.490765 40

ion channel activity

calmodulin binding

ion transport

potassium ion transport

membrane

integral to membrane

small conductance calcium-activated potassium channel activity

 
1557165_s_at 0.579 8.697 2.415 2.879e-02 0.534 -3.447 KLHL18 kelch-like 18 (Drosophila) 3 47299333 BM141828 3p21.31 Hs.517946 8

protein binding

 
204633_s_at 0.600 6.956 2.289 3.682e-02 0.561 -3.652 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 14 -90430071, -90406922 AF074393 14q31-q32.1 Hs.510225 47

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

cytoplasm

regulation of transcription, DNA-dependent

response to stress

epidermal growth factor receptor signaling pathway

protein kinase cascade

response to external stimulus

histone phosphorylation

transferase activity

response to chemical stimulus

MAPK signaling pathway

Neurotrophin signaling pathway

Bladder cancer

201914_s_at SEC63 SEC63 homolog (S. cerevisiae) 6 -108295652 AK001465 6q21 Hs.26904 14

receptor activity

endoplasmic reticulum

protein folding

protein targeting to membrane

protein transport

membrane

integral to membrane

heat shock protein binding

unfolded protein binding

 
220248_x_at 0.278 9.150 2.764 1.432e-02 0.447 -2.861 NSFL1C NSFL1 (p97) cofactor (p47) 20 -1370810 NM_018839 20p13 Hs.12865 20

protein binding

nucleus

Golgi apparatus

Golgi stack

lipid binding

 
1552789_at SEC62 SEC62 homolog (S. cerevisiae) 3 171167273 NM_153039 3q26.2 Hs.622596 10

receptor activity

endoplasmic reticulum

cytoskeleton

cotranslational protein targeting to membrane

protein transporter activity

protein transport

membrane

integral to membrane

intracellular protein transmembrane transport

 
213860_x_at 0.373 8.864 2.251 3.960e-02 0.568 -3.712 CSNK1A1 casein kinase 1, alpha 1 5 -148855037 AW268585 5q32 Hs.529862 Hs.712555 53

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

cytosol

protein amino acid phosphorylation

Wnt receptor signaling pathway

transferase activity

Wnt signaling pathway

Hedgehog signaling pathway

228248_at RICTOR RPTOR independent companion of MTOR, complex 2 5 -38973779 W49629 5p13.1 Hs.407926 21

guanyl-nucleotide exchange factor activity

protein binding

intracellular

embryonic development

positive regulation of actin filament polymerization

actin cytoskeleton reorganization

TORC2 complex

positive regulation of TOR signaling pathway

regulation of Rac GTPase activity

regulation of actin cytoskeleton organization

positive regulation of peptidyl-tyrosine phosphorylation

regulation of small GTPase mediated signal transduction

regulation of protein kinase B signaling cascade

mTOR signaling pathway

208877_at PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 3 197951124 W74494 3q29 Hs.518530 80

nucleotide binding

protein serine/threonine kinase activity

ATP binding

nucleus

cytoplasm

cytosol

negative regulation of protein kinase activity

apoptosis

signal transduction

membrane

transferase activity

regulation of growth

identical protein binding

interspecies interaction between organisms

protein amino acid autophosphorylation

perinuclear region of cytoplasm

MAPK signaling pathway

ErbB signaling pathway

Axon guidance

Focal adhesion

T cell receptor signaling pathway

Regulation of actin cytoskeleton

Renal cell carcinoma

215554_at GPLD1 glycosylphosphatidylinositol specific phospholipase D1 6 -24581304, -24536383 AV699786 6p22.3-p22.2 Hs.533291 26

glycosylphosphatidylinositol phospholipase D activity

extracellular region

hydrolase activity

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

201867_s_at 0.350 3.416 3.040 8.165e-03 0.387 -2.384 TBL1X transducin (beta)-like 1X-linked X 9391334, 9393200 AW968555 Xp22.3 Hs.495656 16

nucleus

signal transduction

visual perception

sensory perception of sound

modification-dependent protein catabolic process

regulation of transcription

Wnt signaling pathway

201857_at ZFR zinc finger RNA binding protein 5 -32390212 NM_016107 5p13.3 Hs.435231 6

DNA binding

RNA binding

intracellular

nucleus

nucleolus

cytoplasm

multicellular organismal development

zinc ion binding

 
201862_s_at LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 2 238200962, 238265545, 238265545 NM_004735 2q37.3 Hs.471779 16

DNA binding

double-stranded RNA binding

protein binding

nucleus

cytoplasm

cytoskeleton

regulation of transcription from RNA polymerase II promoter

negative regulation of transcription

transcription repressor activity

 
202723_s_at 0.793 6.727 4.627 3.178e-04 0.179 0.360 FOXO1 forkhead box O1 13 -40027800 AW117498 13q14.1 Hs.370666 140

blood vessel development

transcription factor activity

protein binding

nucleus

cytoplasm

regulation of transcription, DNA-dependent

anti-apoptosis

insulin receptor signaling pathway

transcription activator activity

regulation of cell proliferation

sequence-specific DNA binding

positive regulation of transcription from RNA polymerase II promoter

Insulin signaling pathway

Pathways in cancer

Prostate cancer

208872_s_at 0.645 8.350 2.518 2.345e-02 0.507 -3.276 REEP5 receptor accessory protein 5 5 -112239979 AA814140 5q22-q23 Hs.429608 11

molecular_function

protein binding

biological_process

membrane

integral to membrane

 
205248_at -0.625 5.898 -2.409 2.910e-02 0.535 -3.456 DOPEY2 dopey family member 2 21 36458708 NM_005128 21q22.2 Hs.204575 12

Golgi membrane

molecular_function

Golgi to endosome transport

endoplasmic reticulum organization

multicellular organismal development

protein transport

 
1557170_at -0.277 5.687 -2.876 1.141e-02 0.426 -2.668 NEK8 NIMA (never in mitosis gene a)- related kinase 8 17 24079958 AI073943 17q11.1 Hs.448468 8

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

protein amino acid phosphorylation

transferase activity

 
232844_at IFT140 intraflagellar transport 140 homolog (Chlamydomonas) 16 -1500429 AU159127 16p13.3 Hs.389438 6    
203590_at 0.237 7.840 2.411 2.898e-02 0.534 -3.453 DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 16 -65312299 NM_006141 16q22.1 Hs.369068 10

nucleotide binding

motor activity

ATP binding

cytoplasmic dynein complex

microtubule

 
237284_at DNAJB8 DnaJ (Hsp40) homolog, subfamily B, member 8 3 -129663971 AI188219 3q21.3 Hs.518241 3

heat shock protein binding

 
1553935_at -0.224 2.672 -2.508 2.393e-02 0.509 -3.293 MGC2848 hypothetical protein MGC2848 3   NM_032917 3q22.1 Hs.435710 1    
227736_at C10orf99 chromosome 10 open reading frame 99 10 85923533 AA553959 10q23.1 Hs.298713 1

extracellular region

 
1554634_at PDS5B PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 13 32058591 BC039256 13q12.3 Hs.716441 15

chromatin

DNA binding

ATP binding

nucleus

cell cycle

mitotic sister chromatid cohesion

mitosis

negative regulation of cell proliferation

identical protein binding

cell division

 
235297_at CUGBP1 CUG triplet repeat, RNA binding protein 1 11 -47446520, -47446520, -47446520 BG286365 11p11 Hs.632137 34

nucleotide binding

translation repressor activity, nucleic acid binding

mRNA binding

nucleus

cytoplasm

mRNA splice site selection

mRNA processing

germ cell development

embryonic development

RNA interference

ribonucleoprotein complex

BRE binding

 
227714_s_at C9orf86 chromosome 9 open reading frame 86 9 138822201 AI971522 9q34.3 Hs.370555 11

nucleotide binding

protein binding

GTP binding

nucleus

cytoplasm

small GTPase mediated signal transduction

 
219237_s_at DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 4 -101039734 NM_024920 4q23 Hs.577426 6

protein folding

membrane

integral to membrane

heat shock protein binding

unfolded protein binding

 
225242_s_at 1.396 5.742 4.494 4.144e-04 0.192 0.139 CCDC80 coiled-coil domain containing 80 3 -113806098 AW303375 3q13.2 Hs.477128 10

fibronectin binding

extracellular region

basement membrane

interstitial matrix

heparin binding

positive regulation of cell-substrate adhesion

extracellular matrix organization

intracellular membrane-bounded organelle

 
220407_s_at 0.398 4.017 2.285 3.706e-02 0.562 -3.657 TGFB2 transforming growth factor, beta 2 1 216586013 NM_003238 1q41 Hs.133379 112

cell morphogenesis

skeletal system development

cartilage condensation

angiogenesis

beta-amyloid binding

blood vessel development

eye development

response to hypoxia

blood vessel remodeling

receptor signaling protein serine/threonine kinase activity

type II transforming growth factor beta receptor binding

type II transforming growth factor beta receptor binding

cytokine activity

extracellular region

extracellular region

extracellular region

extracellular space

induction of apoptosis

activation-induced cell death of T cells

cell cycle arrest

transforming growth factor beta receptor signaling pathway

SMAD protein nuclear translocation

cell-cell signaling

axon guidance

salivary gland morphogenesis

growth factor activity

cell death

positive regulation of cell proliferation

glial cell migration

embryonic development

positive regulation of epithelial cell migration

negative regulation of alkaline phosphatase activity

positive regulation of epithelial to mesenchymal transition

positive regulation of phosphoinositide 3-kinase cascade

menstrual cycle phase

hemopoiesis

collagen fibril organization

positive regulation of cell growth

negative regulation of cell growth

axon

neutrophil chemotaxis

neutrophil chemotaxis

extracellular matrix

hair follicle morphogenesis

platelet alpha granule lumen

activation of protein kinase activity

response to progesterone stimulus

positive regulation of stress-activated MAPK cascade

regulation of transforming growth factor-beta2 production

positive regulation of cell adhesion mediated by integrin

wound healing

dopamine biosynthetic process

odontogenesis

protein homodimerization activity

cell soma

positive regulation of neuron apoptosis

cell-cell junction organization

positive regulation of integrin biosynthetic process

positive regulation of ossification

positive regulation of cell cycle

positive regulation of heart contraction

protein heterodimerization activity

somatic stem cell division

neuron fate commitment

neuron development

generation of neurons

negative regulation of epithelial cell proliferation

negative regulation of epithelial cell proliferation

positive regulation of protein secretion

negative regulation of immune response

positive regulation of immune response

positive regulation of catagen

positive regulation of cardioblast differentiation

cardiac muscle cell proliferation

cardiac epithelial to mesenchymal transition

pathway-restricted SMAD protein phosphorylation

MAPK signaling pathway

Cytokine-cytokine receptor interaction

Cell cycle

TGF-beta signaling pathway

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Chronic myeloid leukemia

Hypertrophic cardiomyopathy (HCM)

233191_at RUFY2 RUN and FYVE domain containing 2 10 -69806955, -69773280 AB040970 10q21.3 Hs.653144 5

nucleus

zinc ion binding

metal ion binding

 
235343_at 0.766 3.146 2.495 2.456e-02 0.513 -3.314 VASH2 vasohibin 2 1 211190509 AI961235 1q32.3 Hs.96885 5    
210732_s_at 0.750 2.848 3.914 1.348e-03 0.245 -0.853 LGALS8 lectin, galactoside-binding, soluble, 8 1 234748187, 234753361, 234753699 AF342816 1q42-q43 Hs.4082 Hs.708114 29

sugar binding

extracellular space

cytoplasm

 
225674_at BCAP29 B-cell receptor-associated protein 29 7 107007657, 107008439 AW873330 7q22-q31 Hs.303787 12

endoplasmic reticulum

intracellular protein transport

apoptosis

membrane

integral to membrane

vesicle-mediated transport

 
204722_at 0.915 6.199 2.601 1.989e-02 0.491 -3.137 SCN3B sodium channel, voltage-gated, type III, beta 11 -123005104 AW007335 11q23.3 Hs.4865 19

voltage-gated ion channel activity

voltage-gated sodium channel activity

plasma membrane

ion transport

sodium ion transport

integral to membrane

sodium ion binding

 
41387_r_at -0.261 6.770 -2.168 4.644e-02 0.582 -3.843 KDM6B lysine (K)-specific demethylase 6B 17 7683959 AB002344 17p13.1 Hs.223678 8

negative regulation of transcription from RNA polymerase II promoter

binding

iron ion binding

nucleus

inflammatory response

oxidoreductase activity

chromatin modification

histone demethylation

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

sequence-specific DNA binding

metal ion binding

oxidation reduction

 
205389_s_at ANK1 ankyrin 1, erythrocytic 8 -41629901, -41629901, -41629900 AI659683 8p11.1 Hs.654438 Hs.667377 49

structural constituent of cytoskeleton

cytoplasm

plasma membrane

exocytosis

cytoskeleton organization

signal transduction

cytoskeletal adaptor activity

spectrin-associated cytoskeleton

basolateral plasma membrane

sarcoplasmic reticulum

enzyme binding

spectrin binding

M band

maintenance of epithelial cell apical/basal polarity

 
211780_x_at DCTN1 dynactin 1 (p150, glued homolog, Drosophila) 2 -74441789, -74441789 BC006163 2p13 Hs.516111 74

spindle pole

motor activity

protein binding

cytoplasm

cytoskeleton

microtubule

mitosis

nervous system development

cell death

dynein complex

Huntington's disease

203137_at WTAP Wilms tumor 1 associated protein 6 160068141, 160068141, 160068609 NM_004906 6q25-q27 Hs.446091 Hs.710715 16

nucleus

nucleolus

mRNA processing

cell cycle

RNA splicing

nuclear membrane

 
1552344_s_at CNOT7 CCR4-NOT transcription complex, subunit 7 8 -17133392, -17131110 NM_054026 8p22-p21.3 Hs.645009 Hs.719129 19

nucleic acid binding

transcription factor activity

signal transducer activity

protein binding

nucleus

carbohydrate metabolic process

signal transduction

transcription activator activity

CCR4-NOT complex

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

RNA degradation

213970_at RABL3 RAB, member of RAS oncogene family-like 3 3 -121888217 AA744682 3q13.33 Hs.444360 1

nucleotide binding

GTP binding

intracellular

small GTPase mediated signal transduction

 
208042_at AGGF1 angiogenic factor with G patch and FHA domains 1 5 76361987 NM_013303 5q13.3 Hs.634849 12

vasculogenesis

positive regulation of endothelial cell proliferation

nucleic acid binding

protein binding

extracellular region

intracellular

cytoplasm

RNA processing

cell adhesion

multicellular organismal development

eukaryotic cell surface binding

positive regulation of angiogenesis

perinuclear region of cytoplasm

 
225081_s_at -0.614 5.590 -2.254 3.935e-02 0.567 -3.707 CDCA7L cell division cycle associated 7-like 7 -21907042 AK022955 7p15.3 Hs.520245 Hs.655326 15

nucleus

cytoplasm

regulation of transcription

 
236813_at 0.619 5.600 4.206 7.419e-04 0.211 -0.349 MORN4 MORN repeat containing 4 10 -99364299, -99364299 N21659 10q24.2 Hs.217409 6    
213467_at RND2 Rho family GTPase 2 17 38430783 BF511718 17q21 Hs.603111 16

nucleotide binding

GTPase activity

protein binding

GTP binding

intracellular

plasma membrane

signal transduction

small GTPase mediated signal transduction

 
207851_s_at 0.289 4.924 2.184 4.499e-02 0.581 -3.817 INSR insulin receptor 19 -7063265 NM_000208 19p13.3-p13.2 Hs.465744 351

nucleotide binding

activation of MAPK activity

positive regulation of protein amino acid phosphorylation

heart morphogenesis

receptor signaling protein tyrosine kinase activity

receptor activity

insulin receptor activity

insulin-like growth factor receptor binding

ATP binding

GTP binding

endosome

microsome

cytosol

plasma membrane

plasma membrane

insulin receptor complex

caveola

carbohydrate metabolic process

G-protein coupled receptor protein signaling pathway

positive regulation of cell proliferation

positive regulation of cell proliferation

insulin receptor signaling pathway

endosome membrane

transferase activity

peptidyl-tyrosine phosphorylation

transformation of host cell by virus

protein phosphatase binding

male sex determination

positive regulation of cell migration

insulin-like growth factor I binding

insulin-like growth factor II binding

activation of protein kinase B activity

regulation of gene-specific transcription

SH2 domain binding

glucose homeostasis

positive regulation of MAPKKK cascade

3-phosphoinositide-dependent protein kinase binding

phosphoinositide 3-kinase binding

insulin binding

insulin receptor substrate binding

positive regulation of nitric oxide biosynthetic process

positive regulation of glycogen biosynthetic process

positive regulation of DNA replication

positive regulation of glycolysis

positive regulation of mitosis

regulation of embryonic development

positive regulation of glucose import

positive regulation of glucose import

protein amino acid autophosphorylation

positive regulation of developmental growth

protein heterotetramerization

PTB domain binding

positive regulation of protein kinase B signaling cascade

positive regulation of respiratory burst

Adherens junction

Insulin signaling pathway

Type II diabetes mellitus

212947_at SLC9A8 solute carrier family 9 (sodium/hydrogen exchanger), member 8 20 47862656 AL031685 20q13.13 Hs.444202 12

Golgi apparatus

cation transport

sodium ion transport

regulation of pH

antiporter activity

solute:hydrogen antiporter activity

sodium:hydrogen antiporter activity

membrane

integral to membrane

sodium ion binding

 
207148_x_at MYOZ2 myozenin 2 4 120276386 NM_016599 4q26-q27 Hs.381047 16

protein binding

cytoplasm

biological_process

actin cytoskeleton

sarcomere

Z disc

protein phosphatase 2B binding

 
219027_s_at MYO9A myosin IXA 15 -69905414 NM_006901 15q22-q23 Hs.546268 8

nucleotide binding

motor activity

actin binding

GTPase activator activity

protein binding

ATP binding

intracellular

intracellular signaling cascade

visual perception

zinc ion binding

membrane

integral to membrane

myosin complex

diacylglycerol binding

metal ion binding

 
227930_at EIF2C4 eukaryotic translation initiation factor 2C, 4 1 36046414 AI669957 1p34.3 Hs.471492 8

cytoplasmic mRNA processing body

RNA binding

protein binding

cytoplasm

mRNA catabolic process

regulation of translation

gene silencing by RNA

gene silencing by miRNA, negative regulation of translation

 
217969_at C11orf2 chromosome 11 open reading frame 2 11 64620258 NM_013265 11q13 Hs.277517 6

molecular_function

Golgi apparatus

lipid transport

biological_process

protein transport

integral to membrane

 
232194_at METTL4 methyltransferase like 4 18 -2527523 AA764787 18p11.32 Hs.126888 4

nucleic acid binding

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

methyltransferase activity

transferase activity

methylation

 
204545_at -1.236 5.578 -3.338 4.426e-03 0.330 -1.863 PEX6 peroxisomal biogenesis factor 6 6 -43039588 NM_000287 6p21.1 Hs.656425 20

nucleotide binding

ATP binding

cytoplasm

peroxisome

peroxisomal membrane

cytosol

protein targeting to peroxisome

protein C-terminus binding

membrane

protein import into peroxisome matrix, translocation

protein complex binding

ATPase activity, coupled

protein stabilization

 
232609_at CRB3 crumbs homolog 3 (Drosophila) 19 6415259 BC002652 19p13.3 Hs.150319 11

plasma membrane

tight junction

integral to membrane

cell junction

Tight junction

207457_s_at LY6G6D lymphocyte antigen 6 complex, locus G6D 6 31791111, 3129252, 2930718 NM_021246 6p21.3 Hs.591792 2

protein binding

cytosol

plasma membrane

defense response

response to unfolded protein

response to nutrient

anchored to membrane

protein complex

NF-kappaB binding

 
200789_at ECH1 enoyl Coenzyme A hydratase 1, peroxisomal 19 -43997901 NM_001398 19q13.1 Hs.196176 9

enoyl-CoA hydratase activity

protein binding

mitochondrion

peroxisome

generation of precursor metabolites and energy

lipid metabolic process

fatty acid metabolic process

fatty acid beta-oxidation

metabolic process

isomerase activity

Tyrosine metabolism

208997_s_at UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 11 -73363363 U82819 11q13 Hs.80658 153

response to superoxide

binding

mitochondrion

mitochondrial inner membrane

transport

mitochondrial transport

proton transport

membrane

integral to membrane

 
214890_s_at 2.248 5.468 6.943 4.362e-06 0.039 3.757 FAM149A family with sequence similarity 149, member A 4 187302988, 187307320 AL080065 4q35.1 Hs.357025 3    
201898_s_at UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog) X 118592526, 118598325 AI126625 Xq24-q25 Hs.379466 16

nucleotide binding

chromatin

ubiquitin-protein ligase activity

ATP binding

postreplication repair

ubiquitin-dependent protein catabolic process

response to DNA damage stimulus

positive regulation of cell proliferation

response to UV

ligase activity

ubiquitin protein ligase binding

histone H2A ubiquitination

post-translational protein modification

regulation of protein metabolic process

protein autoubiquitination

Ubiquitin mediated proteolysis

204066_s_at AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2 236067474 NM_014914 2q37 Hs.435039 11

nucleotide binding

GTP binding

intracellular

cytoplasm

small GTPase mediated signal transduction

ARF GTPase activator activity

zinc ion binding

protein transport

regulation of ARF GTPase activity

metal ion binding

Endocytosis

213251_at SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 4 144654065 AV712064 4q31.1-q31.2 Hs.558422 Hs.710623 37

nucleotide binding

condensed chromosome

DNA binding

RNA polymerase II transcription factor activity

helicase activity

ATP binding

nucleus

nucleoplasm

nucleolus

chromatin assembly or disassembly

nucleosome assembly

transcription initiation

regulation of transcription from RNA polymerase II promoter

embryonic development

transcription activator activity

nucleosome positioning

hydrolase activity

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ATPase activity

RSF complex

nucleosome binding

histone binding

ATP-dependent chromatin remodeling

 
222611_s_at 0.606 5.386 3.336 4.437e-03 0.330 -1.865 PSPC1 paraspeckle component 1 13 -19175008, -19146895 AA969958 13q12.11 Hs.213198 9

nucleotide binding

RNA binding

protein binding

nucleus

nucleolus

cytoplasm

nuclear matrix

regulation of transcription

 
204173_at MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 12 54832601 NM_002475 12q13.13 Hs.632731 8

motor activity

calcium ion binding

protein binding

muscle myosin complex

skeletal muscle tissue development

structural constituent of muscle

unconventional myosin complex

muscle filament sliding

 
228613_at RAB11FIP3 RAB11 family interacting protein 3 (class II) 16 415668, 464850 BF183535 16p13.3 Hs.531642 18

calcium ion binding

protein binding

protein transport

membrane

Rab GTPase binding

recycling endosome

Endocytosis

201096_s_at 0.329 7.868 2.841 1.227e-02 0.427 -2.729 ARF4 ADP-ribosylation factor 4 3 -57532129 AL537042 3p21.2-p21.1 Hs.695943 19

nucleotide binding

GTPase activity

GTP binding

intracellular

cytoplasm

Golgi apparatus

plasma membrane

small GTPase mediated signal transduction

protein transport

vesicle-mediated transport

 
202972_s_at FAM13A family with sequence similarity 13, member A 4 -89866128, -89866128 AW450403 4q22.1 Hs.97270 7    
214429_at MTMR6 myotubularin related protein 6 13 -24718340 U47635 13q12 Hs.643702 17

protein serine/threonine phosphatase activity

protein tyrosine phosphatase activity

cellular_component

nucleus

nuclear envelope

cytoplasm

protein amino acid dephosphorylation

calcium-activated potassium channel activity

hydrolase activity

phosphatase activity

Fructose and mannose metabolism

Thiamine metabolism

Riboflavin metabolism

Metabolic pathways

225421_at PM20D2 peptidase M20 domain containing 2 6 89912487 AI654133 6q15 Hs.709364 2

proteolysis

metallopeptidase activity

hydrolase activity

protein dimerization activity

 
204076_at ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 8 -23345516, -23345516 AB002390 8p21.3-p21.2 Hs.444389 8

magnesium ion binding

calcium ion binding

Golgi apparatus

UDP catabolic process

membrane

integral to membrane

hydrolase activity

integral to Golgi membrane

cytoplasmic vesicle

uridine-diphosphatase activity

Purine metabolism

Pyrimidine metabolism

Lysosome

218908_at 0.478 5.716 2.673 1.722e-02 0.471 -3.016 ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 17 77528714 NM_024083 17q25.3 Hs.298351 11

molecular_function

protein binding

cellular_component

biological_process

membrane

 
228947_x_at TMEM204 transmembrane protein 204 16 1524231 AW612362 16p13.3 Hs.459652 7

plasma membrane

adherens junction

response to stress

integral to membrane

cell junction

 
1553177_at SH2D1B SH2 domain containing 1B 1 -160631679 BC022407 1q23.3 Hs.350581 10

molecular_function

protein binding

cellular_component

biological_process

Natural killer cell mediated cytotoxicity

205383_s_at 0.344 8.745 2.843 1.220e-02 0.426 -2.725 ZBTB20 zinc finger and BTB domain containing 20 3 -115540212 NM_015642 3q13.2 Hs.655108 13

DNA binding

protein binding

intracellular

nucleus

nucleolus

zinc ion binding

regulation of transcription

metal ion binding

 
224937_at 0.874 4.284 3.442 3.567e-03 0.312 -1.679 PTGFRN prostaglandin F2 receptor negative regulator 1 117254211 BF311866 1p13.1 Hs.418093 14

protein binding

endoplasmic reticulum

Golgi apparatus

membrane

integral to membrane

 
224371_at -0.247 4.366 -3.206 5.806e-03 0.357 -2.094 ADAMTSL1 ADAMTS-like 1 9 18464103, 18464103 AF251058 9p22.2-p22.1 Hs.522019 10

extracellular region

proteinaceous extracellular matrix

peptidase activity

metallopeptidase activity

zinc ion binding

 
204306_s_at 0.570 7.177 3.618 2.480e-03 0.287 -1.370 CD151 CD151 molecule (Raph blood group) 11 822951 NM_004357 11p15.5 Hs.654379 55

protein binding

membrane fraction

plasma membrane

integral to plasma membrane

cell adhesion

 
217047_s_at FAM13A family with sequence similarity 13, member A 4 -89866128, -89866128 AK027138 4q22.1 Hs.97270 7    
223479_s_at CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 113058506 BC004498 2q13 Hs.375707 3    
212328_at LIMCH1 LIM and calponin homology domains 1 4 41057560, 41309675 AB029025 4p13 Hs.335163 10

actin binding

zinc ion binding

actomyosin structure organization

metal ion binding

 
203675_at NUCB2 nucleobindin 2 11 17254861 NM_005013 11p15.1-p14 Hs.654599 15

DNA binding

calcium ion binding

extracellular region

extracellular space

nucleus

nuclear outer membrane

cytoplasm

endoplasmic reticulum

ER-Golgi intermediate compartment

Golgi apparatus

cytosol

plasma membrane

 
215022_x_at 0.554 3.269 3.430 3.656e-03 0.314 -1.700 ZNF33B zinc finger protein 33B 10 -42404560 BG429214 10q11.2 Hs.499453 9

transcription factor activity

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
201419_at BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 3 -52410064 NM_004656 3p21.31-p21.2 Hs.106674 16

ubiquitin thiolesterase activity

protein binding

intracellular

nucleus

protein modification process

ubiquitin-dependent protein catabolic process

peptidase activity

cysteine-type peptidase activity

negative regulation of cell proliferation

 
48808_at 0.734 6.165 2.214 4.251e-02 0.575 -3.771 DHFR dihydrofolate reductase 5 -79957800 AI144299 5q11.2-q13.2 Hs.592364 Hs.648635 80

dihydrofolate reductase activity

cellular_component

glycine biosynthetic process

one-carbon metabolic process

nucleotide biosynthetic process

oxidoreductase activity

NADP or NADPH binding

oxidation reduction

One carbon pool by folate

Folate biosynthesis

Biosynthesis of phenylpropanoids

Metabolic pathways

207289_at MMP25 matrix metallopeptidase 25 16 3036682 NM_004142 16p13.3 Hs.654979 16

metalloendopeptidase activity

calcium ion binding

extracellular region

proteinaceous extracellular matrix

plasma membrane

proteolysis

inflammatory response

metabolic process

peptidase activity

zinc ion binding

cell surface

anchored to membrane

 
204595_s_at STC1 stanniocalcin 1 8 -23755378 AI300520 8p21-p11.2 Hs.25590 35

hormone activity

extracellular region

extracellular space

cellular calcium ion homeostasis

cell surface receptor linked signal transduction

cell-cell signaling

response to nutrient

 
226445_s_at 0.398 7.086 4.032 1.058e-03 0.226 -0.648 TRIM41 tripartite motif-containing 41 5 180582911 AI743109 5q35.3 Hs.441488 9

protein binding

intracellular

nucleus

cytoplasm

zinc ion binding

metal ion binding

 
202984_s_at BAG5 BCL2-associated athanogene 5 14 -103092641, -103092641, -103092641 AA457021 14q32.33 Hs.5443 10

protein binding

protein folding

apoptosis

 
221854_at PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 1 199519202 AI378979 1q32 Hs.497350 26

signal transducer activity

protein binding

nucleus

intermediate filament

cell adhesion

signal transduction

multicellular organismal development

intermediate filament binding

cell junction

desmosome

structural constituent of epidermis

 
209075_s_at -0.338 11.329 -2.840 1.227e-02 0.427 -2.730 ISCU iron-sulfur cluster scaffold homolog (E. coli) 12 107480423 AY009128 12q24.1 Hs.615131 14

iron ion binding

nucleus

cytoplasm

mitochondrion

cytosol

nitrogen fixation

iron-sulfur cluster assembly

protein complex scaffold

metal ion binding

iron-sulfur cluster binding

 
1558762_a_at -0.247 5.053 -2.447 2.702e-02 0.525 -3.394 ZNF789 zinc finger protein 789 7 98908450, 98908450 AK093141 7q22.1 Hs.440384 4

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
217187_at -0.395 6.696 -2.600 1.992e-02 0.491 -3.139 MUC5AC mucin 5AC, oligomeric mucus/gel-forming 11 1132473 Z34282 11p15.5 Hs.534332 Hs.558950 95

molecular_function

protein binding

extracellular region

apoptosis

induction of apoptosis

cell adhesion

digestion

biological_process

negative regulation of cell proliferation

extracellular matrix constituent, lubricant activity

negative regulation of cell migration

fibril

fibril organization

 
229711_s_at MDM2 Mdm2 p53 binding protein homolog (mouse) 12 67488237, 67489063 AA902480 12q14.3-q15 Hs.484551 555

negative regulation of transcription from RNA polymerase II promoter

negative regulation of transcription from RNA polymerase II promoter

p53 binding

ubiquitin-protein ligase activity

intracellular

insoluble fraction

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

cytosol

protein complex assembly

zinc ion binding

positive regulation of cell proliferation

ligase activity

basal transcription repressor activity

basal transcription repressor activity

enzyme binding

modification-dependent protein catabolic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process

protein ubiquitination during ubiquitin-dependent protein catabolic process

identical protein binding

interspecies interaction between organisms

metal ion binding

Cell cycle

p53 signaling pathway

Ubiquitin mediated proteolysis

Endocytosis

Pathways in cancer

Glioma

Prostate cancer

Melanoma

Bladder cancer

Chronic myeloid leukemia

231015_at KLF15 Kruppel-like factor 15 3 -127544167 AW014734 3q13-q21 Hs.272215 10

transcription factor activity

protein binding

intracellular

nucleus

zinc ion binding

glucose transport

regulation of transcription

positive regulation of transcription, DNA-dependent

metal ion binding

 
230683_at 0.425 3.848 3.680 2.184e-03 0.276 -1.262 ANKRD60 ankyrin repeat domain 60 20   W56760 20q13.32   1    
232035_at HIST1H4B histone cluster 1, H4b 6 -26135102 BE740761 6p21.3 Hs.143080 9  

Systemic lupus erythematosus

214264_s_at 0.521 4.440 2.408 2.919e-02 0.535 -3.459 C14orf143 chromosome 14 open reading frame 143 14 -89333221 AI656610 14q32.11 Hs.123232 2

calcium ion binding

 
1555522_s_at MEMO1 mediator of cell motility 1 2 -31946398, -31946397 BC036262 2p22-p21 Hs.444969 10

nucleus

cytosol

 
225747_at COQ10A coenzyme Q10 homolog A (S. cerevisiae) 12 54946908, 54947333 AL521634 12q13.3 Hs.4096 5

mitochondrion

 
235446_at XIST X (inactive)-specific transcript (non-protein coding) X -72957219 AW856618 Xq13.2 Hs.529901 21    
242586_at FSD1L fibronectin type III and SPRY domain containing 1-like 9 107250135, 107250135, 107250145 H07986 9q31 Hs.136901 4

molecular_function

cellular_component

biological_process

 
208804_s_at 0.322 8.152 2.297 3.623e-02 0.558 -3.638 SFRS6 splicing factor, arginine/serine-rich 6 20 41519917 AL031681 20q12-q13.1 Hs.6891 31

nucleotide binding

nuclear mRNA splicing, via spliceosome

RNA binding

protein binding

nucleus

mRNA splice site selection

RNA splicing

 
243916_x_at UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 5 158622666 H73636 5q33.3 Hs.591733 7

phosphoprotein phosphatase activity

nucleus

hydrolase activity

 
226629_at SLC43A2 solute carrier family 43, member 2 17 -1424445 AI742770 17p13.3 Hs.160550 3

plasma membrane

transport

L-amino acid transmembrane transporter activity

L-amino acid transport

integral to membrane

 
228559_at CENPN centromere protein N 16 79597603, 79597603, 79597603 BF111626 16q23.2 Hs.55028 9

chromosome, centromeric region

condensed chromosome kinetochore

nucleus

chromosome

 
200610_s_at NCL nucleolin 2 -232027702 NM_005381 2q12-qter Hs.79110 97

nucleotide binding

angiogenesis

DNA binding

RNA binding

nucleus

nucleolus

cell cortex

protein C-terminus binding

ribonucleoprotein complex

telomeric DNA binding

Pathogenic Escherichia coli infection - EHEC

228077_at 0.472 7.456 2.578 2.084e-02 0.497 -3.177 MRI1 methylthioribose-1-phosphate isomerase homolog (S. cerevisiae) 19 13736336 AK026666 19p13.2 Hs.439370 11

cellular amino acid biosynthetic process

methionine biosynthetic process

isomerase activity

identical protein binding

cellular biosynthetic process

S-methyl-5-thioribose-1-phosphate isomerase activity

 
214252_s_at 0.558 5.333 3.535 2.943e-03 0.298 -1.515 CLN5 ceroid-lipofuscinosis, neuronal 5 13 76464059 AV700514 13q21.1-q32 Hs.30213 19

protein binding

lysosomal membrane

vacuolar lumen

endoplasmic reticulum

Golgi apparatus

lysosomal lumen acidification

brain development

visual perception

integral to membrane

integral to membrane

neurogenesis

protein catabolic process

neuron maturation

perinuclear region of cytoplasm

Lysosome

223143_s_at 0.801 5.361 3.135 6.719e-03 0.367 -2.218 AKIRIN2 akirin 2 6 -88441298 AI742378 6q15 Hs.485915 10

protein binding

nucleus

embryonic development

transcriptional repressor complex

response to lipopolysaccharide

positive regulation of interleukin-6 production

innate immune response

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

 
209394_at 0.386 5.788 2.191 4.439e-02 0.580 -3.806 ASMTL acetylserotonin O-methyltransferase-like X, Y -1482031, -1482031 BC002508 Xp22.3 Yp11.3 Hs.533514 10

cellular_component

cytoplasm

acetylserotonin O-methyltransferase activity

melatonin biosynthetic process

 
226277_at COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 5 -74702683, -74702683 AA889952 5q13.3 Hs.270437 26

protein kinase activity

protein binding

cellular_component

cytoplasm

endoplasmic reticulum

Golgi apparatus

protein amino acid phosphorylation

lipid transport

immune response

 
1569629_x_at -0.254 4.124 -3.319 4.594e-03 0.333 -1.895 LOC389906 similar to Serine/threonine-protein kinase PRKX (Protein kinase PKX1) X   BC017231 Xp22.33 Hs.636199 Hs.684492 1    
242422_at 0.544 4.508 3.028 8.376e-03 0.388 -2.406 G3BP1 GTPase activating protein (SH3 domain) binding protein 1 5 151131668 AA180161 5q33.1 Hs.587054 27

nucleotide binding

DNA binding

RNA binding

ATP-dependent DNA helicase activity

ATP-dependent RNA helicase activity

helicase activity

endonuclease activity

protein binding

ATP binding

intracellular

nucleus

cytoplasm

cytosol

plasma membrane

transport

Ras protein signal transduction

hydrolase activity

 
214622_at -0.272 5.161 -2.253 3.944e-02 0.567 -3.709 CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 6 32114060, 3413239, 3221082 M17252 6p21.3 Hs.654479 185

monooxygenase activity

steroid 21-monooxygenase activity

steroid binding

endoplasmic reticulum

microsome

C21-steroid hormone biosynthetic process

electron carrier activity

membrane

heme binding

metal ion binding

oxidation reduction

C21-Steroid hormone metabolism

Metabolic pathways

230150_at 0.377 5.665 2.628 1.885e-02 0.488 -3.092 BCAP29 B-cell receptor-associated protein 29 7 107007657, 107008439 N57499 7q22-q31 Hs.303787 12

endoplasmic reticulum

intracellular protein transport

apoptosis

membrane

integral to membrane

vesicle-mediated transport

 
1569610_at IQCH IQ motif containing H 15 65334241, 65334247 BC039463 15q23 Hs.657894 5    
1569594_a_at SDCCAG1 serologically defined colon cancer antigen 1 14 -49320281 BC006001 14q22 Hs.655964 8

nucleus

cytoplasm

 
234727_at -0.250 3.198 -2.161 4.704e-02 0.584 -3.854 DNAH7 dynein, axonemal, heavy chain 7 2 -196310671 Z83801 2q32.3 Hs.97403 6

nucleotide binding

ciliary or flagellar motility

microtubule motor activity

ATP binding

axonemal dynein complex

microtubule

cilium

microtubule-based movement

ATPase activity

cilium axoneme

 
235174_s_at 0.415 8.397 2.438 2.749e-02 0.526 -3.409 LOC100128822 hypothetical LOC100128822 7 151792141 AW952781 7q36.1 Hs.647112 2    
239898_x_at -0.266 5.538 -2.343 3.311e-02 0.551 -3.564 ZNF286A zinc finger protein 286A 17 15543615 AI498484 17p11.2 Hs.585799 Hs.659318 7

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
244523_at 0.484 5.944 2.548 2.211e-02 0.499 -3.226 MMD monocyte to macrophage differentiation-associated 17 -50824972 AW104453 17q Hs.463483 Hs.656753 4

receptor activity

membrane fraction

lysosome

endosome

integral to plasma membrane

membrane

cytolysis

 
201641_at BST2 bone marrow stromal cell antigen 2 19 -17374754 NM_004335 19p13.2 Hs.118110 20

signal transducer activity

Golgi apparatus

plasma membrane

integral to plasma membrane

humoral immune response

cell-cell signaling

multicellular organismal development

cell proliferation

response to virus

anchored to membrane

B cell activation

positive regulation of I-kappaB kinase/NF-kappaB cascade

 
206692_at -0.301 2.995 -2.864 1.171e-02 0.426 -2.690 KCNJ10 potassium inwardly-rectifying channel, subfamily J, member 10 1 -158274656 NM_002241 1q22-q23 Hs.408960 25

nucleotide binding

voltage-gated ion channel activity

potassium channel activity

protein binding

ATP binding

integral to plasma membrane

ion transport

potassium ion transport

ATP-activated inward rectifier potassium channel activity

membrane

potassium ion binding

 
218025_s_at PECI peroxisomal D3,D2-enoyl-CoA isomerase 6 -4060925 NM_006117 6p24.3 Hs.15250 15

acyl-CoA binding

dodecenoyl-CoA delta-isomerase activity

binding

peroxisome

peroxisomal matrix

fatty acid metabolic process

metabolic process

isomerase activity

Fatty acid metabolism

211004_s_at ALDH3B1 aldehyde dehydrogenase 3 family, member B1 11 67532623, 67534365 BC002553 11q13 Hs.523841 10

3-chloroallyl aldehyde dehydrogenase activity

aldehyde dehydrogenase [NAD(P)+] activity

alcohol metabolic process

cellular aldehyde metabolic process

lipid metabolic process

oxidoreductase activity

oxidation reduction

Glycolysis / Gluconeogenesis

Histidine metabolism

Tyrosine metabolism

Phenylalanine metabolism

Metabolism of xenobiotics by cytochrome P450

Drug metabolism - cytochrome P450

Metabolic pathways

1553486_a_at -0.268 3.136 -2.806 1.317e-02 0.433 -2.789 C17orf78 chromosome 17 open reading frame 78 17 32807097 NM_173625 17q12 Hs.439154 2

membrane

integral to membrane

 
1564637_a_at FAM98B family with sequence similarity 98, member B 15 36533619, 36533619 BC035600 15q14 Hs.6799 5

protein binding

 
243256_at 0.408 5.437 3.938 1.284e-03 0.240 -0.812 MKNK1 MAP kinase interacting serine/threonine kinase 1 1 -46795677 AW796364 1p33 Hs.371594 28

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

cytoplasm

regulation of translation

protein amino acid phosphorylation

response to stress

protein kinase cascade

transferase activity

MAPK signaling pathway

Insulin signaling pathway

224840_at 0.979 10.230 3.255 5.248e-03 0.348 -2.008 FKBP5 FK506 binding protein 5 6 -35656311, -35649339, -35649339, -35649339 AI753747 6p21.3-p21.2 Hs.407190 50

peptidyl-prolyl cis-trans isomerase activity

FK506 binding

nucleus

cytoplasm

protein folding

isomerase activity

heat shock protein binding

 
236876_at H1FNT H1 histone family, member N, testis-specific 12 47009029 AW013835 12q13.11 Hs.155833 3

nucleotide binding

nuclear chromatin

DNA binding

ATP binding

nucleus

chromosome

multicellular organismal development

spermatogenesis

spermatid nucleus elongation

cell differentiation

chromosome condensation

sperm chromatin condensation

 
213435_at SATB2 SATB homeobox 2 2 -199842468 AB028957 2q33 Hs.516617 9

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

sequence-specific DNA binding

 
226595_at 0.348 6.249 3.573 2.720e-03 0.290 -1.448 SNX21 sorting nexin family member 21 20 43895876 AI935964 20q13.12 Hs.472854 8

protein binding

cell communication

protein transport

phosphoinositide binding

 
202779_s_at 0.841 5.832 3.171 6.241e-03 0.362 -2.155 UBE2S ubiquitin-conjugating enzyme E2S 19 -60604461 NM_014501 19q13.43 Hs.396393 6

nucleotide binding

ubiquitin-protein ligase activity

ATP binding

ligase activity

modification-dependent protein catabolic process

post-translational protein modification

regulation of protein metabolic process

Ubiquitin mediated proteolysis

236061_at PRDM15 PR domain containing 15 21 -42094393, -42091453 BF058757 21q22.3 Hs.473893 Hs.711654 6

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
221528_s_at ELMO2 engulfment and cell motility 2 20 -44428096 BC000143 20q13 Hs.210469 16

binding

cytoplasm

cytoskeleton

phagocytosis

apoptosis

SH3 domain binding

 
218181_s_at 0.318 6.902 2.290 3.673e-02 0.560 -3.650 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2 101680919 NM_017792 2q11.2-q12 Hs.719073 22

nucleotide binding

protein serine/threonine kinase activity

small GTPase regulator activity

ATP binding

cellular_component

protein amino acid phosphorylation

response to stress

protein kinase cascade

transferase activity

MAPK signaling pathway

212676_at NF1 neurofibromin 1 17 26446120, 26446120 AW293356 17q11.2 Hs.113577 204

osteoblast differentiation

metanephros development

response to hypoxia

liver development

negative regulation of endothelial cell proliferation

regulation of cell-matrix adhesion

Ras GTPase activator activity

protein binding

intracellular

nucleus

cytoplasm

signal transduction

Ras protein signal transduction

negative regulation of neuroblast proliferation

brain development

peripheral nervous system development

heart development

visual learning

phosphoinositide 3-kinase cascade

spinal cord development

forebrain astrocyte development

cerebral cortex development

myelination in the peripheral nervous system

actin cytoskeleton organization

collagen fibril organization

adrenal gland development

negative regulation of cell migration

axon

dendrite

positive regulation of Ras GTPase activity

wound healing

negative regulation of transcription factor import into nucleus

negative regulation of MAP kinase activity

negative regulation of MAPKKK cascade

pigmentation

positive regulation of neuron apoptosis

regulation of blood vessel endothelial cell migration

regulation of bone resorption

regulation of glial cell differentiation

positive regulation of adenylate cyclase activity

regulation of angiogenesis

sympathetic nervous system development

camera-type eye morphogenesis

negative regulation of oligodendrocyte differentiation

smooth muscle tissue development

artery morphogenesis

forebrain morphogenesis

cognition

regulation of small GTPase mediated signal transduction

MAPK signaling pathway

208920_at 0.444 5.198 2.860 1.180e-02 0.426 -2.697 SRI sorcin 7 -87672367, -87672367 AV752215 7q21.1 Hs.489040 28

regulation of action potential

receptor binding

calcium channel regulator activity

calcium ion binding

cytoplasm

transport

intracellular sequestering of iron ion

regulation of striated muscle contraction

signal transduction

heart development

muscle organ development

regulation of heart contraction

 
226395_at HOOK3 hook homolog 3 (Drosophila) 8 42871189 AI912618 8p11.21 Hs.162852 13

cytoplasm

Golgi apparatus

cis-Golgi network

cytoskeleton

microtubule

endosome organization

lysosome organization

microtubule binding

endosome to lysosome transport

protein transport

HOPS complex

cytoplasmic microtubule organization

identical protein binding

early endosome to late endosome transport

Golgi localization

FHF complex

 
223880_x_at C20orf24 chromosome 20 open reading frame 24 20 34667580, 34667605 BC004446 20q11.23 Hs.584985 7

molecular_function

protein binding

cellular_component

biological_process

 
208744_x_at 0.272 6.312 2.228 4.135e-02 0.571 -3.748 HSPH1 heat shock 105kDa/110kDa protein 1 13 -30608762 BG403660 13q12.3 Hs.36927 25

nucleotide binding

ATP binding

cytoplasm

response to unfolded protein

 
225579_at 0.651 6.230 3.870 1.474e-03 0.250 -0.929 PQLC3 PQ loop repeat containing 3 2 11212990 AL516202 2p25.1 Hs.274415 5

membrane

integral to membrane

 
1569097_at TP53BP1 tumor protein p53 binding protein 1 15 -41486705, -41486705 BU508386 15q15-q21 Hs.440968 80

condensed chromosome kinetochore

damaged DNA binding

protein binding

intracellular

nucleus

nucleoplasm

nucleoplasm

replication fork

cytoplasm

DNA repair

response to DNA damage stimulus

transcription activator activity

telomeric DNA binding

regulation of transcription

positive regulation of transcription, DNA-dependent

 
212061_at SR140 U2-associated SR140 protein 3 144203061 AB002330 3q23 Hs.596572 4

nucleotide binding

RNA binding

RNA processing

 
214526_x_at PMS2L1 postmeiotic segregation increased 2-like 1 pseudogene 7 -99756198 NM_005394 7q22.1 Hs.634244 Hs.661055 Hs.709266 7

molecular_function

ATP binding

cellular_component

mismatch repair

biological_process

kinase activity

transferase activity

mismatched DNA binding

 
231600_at -0.182 2.078 -2.157 4.744e-02 0.585 -3.861 CLEC12B C-type lectin domain family 12, member B 12 10054497, 10054497 AI657064 12p13.2 Hs.127937 3

receptor activity

binding

sugar binding

plasma membrane

integral to membrane

 
209001_s_at ANAPC13 anaphase promoting complex subunit 13 3 -135679236, -135679236, -135679236 BC005398 3q22.2 Hs.106909 6

nucleus

cell cycle

mitosis

modification-dependent protein catabolic process

cell division

Cell cycle

Ubiquitin mediated proteolysis

238615_at -0.271 2.866 -3.268 5.106e-03 0.346 -1.984 ERLIN2 ER lipid raft associated 2 8 37713254, 37713254, 37713356 AI817403 8p11.2 Hs.705490 13

molecular_function

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

biological_process

membrane

integral to membrane

 
1569677_a_at -0.312 2.454 -3.454 3.483e-03 0.309 -1.659 C8orf45 chromosome 8 open reading frame 45 8 67945537, 67945537, 67946290 BC034576 8q13.1 Hs.437006 2    
209939_x_at 0.583 8.223 2.530 2.291e-02 0.503 -3.256 CFLAR CASP8 and FADD-like apoptosis regulator 2 201689060, 201689134, 201691631 AF005775 2q33-q34 Hs.390736 163

cysteine-type endopeptidase activity

protein binding

proteolysis

anti-apoptosis

induction of apoptosis by extracellular signals

regulation of apoptosis

positive regulation of I-kappaB kinase/NF-kappaB cascade

interspecies interaction between organisms

Apoptosis

232518_at PRIC285 peroxisomal proliferator-activated receptor A interacting complex 285 20 -61659882, -61659882 AL121829 20q13.33 Hs.517180 9

nucleotide binding

DNA binding

transcription coactivator activity

RNA binding

helicase activity

ribonuclease activity

ATP binding

intracellular

nucleus

zinc ion binding

hydrolase activity

regulation of transcription

metal ion binding

 
214646_at -0.302 4.847 -3.333 4.471e-03 0.331 -1.872 HIST1H3J histone cluster 1, H3j 6 -27966071 AL522145 6p22-p21.3 Hs.484990 8  

Systemic lupus erythematosus

217487_x_at -0.250 5.313 -2.381 3.073e-02 0.542 -3.502 FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 11 -49124762 AF254357 11p11.2 Hs.654487 86

carboxypeptidase activity

membrane fraction

cytoplasm

plasma membrane

integral to plasma membrane

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

dipeptidase activity

metal ion binding

 
229439_s_at -0.260 5.334 -2.138 4.918e-02 0.590 -3.890 RBM47 RNA binding motif protein 47 4 -40120028, -40120028 AI830823 4p13-p12 Hs.518727 4

RNA binding

nucleus

 
205975_s_at -0.344 4.748 -2.533 2.278e-02 0.502 -3.251 HOXD1 homeobox D1 2 176761552 NM_024501 2q31.1 Hs.83465 14

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

sequence-specific DNA binding

 
215075_s_at GRB2 growth factor receptor-bound protein 2 17 -70825751, -70825751 L29511 17q24-q25 Hs.444356 Hs.708119 438

SH3/SH2 adaptor activity

epidermal growth factor receptor binding

Golgi apparatus

cytosol

cytosol

epidermal growth factor receptor signaling pathway

Ras protein signal transduction

Ras protein signal transduction

cell-cell signaling

insulin receptor signaling pathway

insulin receptor substrate binding

interspecies interaction between organisms

MAPK signaling pathway

ErbB signaling pathway

Chemokine signaling pathway

Dorso-ventral axis formation

Focal adhesion

Gap junction

Jak-STAT signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Neurotrophin signaling pathway

Insulin signaling pathway

GnRH signaling pathway

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Endometrial cancer

Glioma

Prostate cancer

Chronic myeloid leukemia

Acute myeloid leukemia

Non-small cell lung cancer

234947_s_at C10orf84 chromosome 10 open reading frame 84 10 -120058561 AK026630 10q26.11 Hs.372309 5    
225889_at 0.339 6.137 2.443 2.721e-02 0.526 -3.400 AEBP2 AE binding protein 2 12 19483874 BF475280 12p12.3 Hs.126497 5

DNA binding

transcription corepressor activity

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

chromatin modification

metal ion binding

 
207001_x_at 0.577 6.615 3.521 3.029e-03 0.300 -1.540 TSC22D3 TSC22 domain family, member 3 X -106843107, -106843107, -106843107 NM_004089 Xq22.3 Hs.716410 24

transcription factor activity

regulation of transcription, DNA-dependent

 
214074_s_at 0.302 5.140 2.192 4.432e-02 0.579 -3.805 CTTN cortactin 11 69922259, 69922291 BG475299 11q13 Hs.596164 106

ruffle

protein binding

soluble fraction

cytoplasm

cytoskeleton

cell cortex

lamellipodium

Tight junction

Pathogenic Escherichia coli infection - EHEC

235520_at 0.510 3.502 3.194 5.954e-03 0.357 -2.115 ZNF280C zinc finger protein 280C X -129164362 AA805654 Xq26.1 Hs.308418 4

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
227523_s_at 0.402 6.197 3.014 8.603e-03 0.391 -2.428 PHF20L1 PHD finger protein 20-like 1 8 133856785, 133856785, 133856785 AA192936 8q24.22 Hs.304362 4

nucleic acid binding

protein binding

zinc ion binding

metal ion binding

 
1553015_a_at -0.244 6.144 -2.142 4.878e-02 0.590 -3.883 RECQL4 RecQ protein-like 4 8 -145707478 NM_004260 8q24.3 Hs.31442 38

nucleotide binding

bubble DNA binding

DNA strand renaturation

DNA strand annealing activity

nucleic acid binding

DNA helicase activity

ATP binding

nucleus

cytoplasm

DNA repair

DNA recombination

multicellular organismal development

ATP-dependent helicase activity

zinc ion binding

hydrolase activity

DNA duplex unwinding

ATP-dependent 3'-5' DNA helicase activity

 
207403_at IRS4 insulin receptor substrate 4 X -107862382 NM_003604 Xq22.3 Hs.460872 21

SH3/SH2 adaptor activity

insulin receptor binding

protein binding

plasma membrane

signal transduction

Neurotrophin signaling pathway

Insulin signaling pathway

Adipocytokine signaling pathway

Type II diabetes mellitus

209339_at -0.304 5.908 -2.802 1.327e-02 0.435 -2.796 SIAH2 seven in absentia homolog 2 (Drosophila) 3 -151941599 U76248 3q25 Hs.477959 Hs.692394 34

transcription corepressor activity

ubiquitin-protein ligase activity

protein binding

nucleus

cytoplasm

ubiquitin-dependent protein catabolic process

apoptosis

cell cycle

small GTPase mediated signal transduction

multicellular organismal development

zinc ion binding

protein ubiquitination

ligase activity

metal ion binding

 
207797_s_at 0.424 4.932 3.371 4.130e-03 0.323 -1.804 LRP2BP LRP2 binding protein 4 -186522026 NM_018409 4q35.1 Hs.558513 4

protein binding

cytoplasm

 
241425_at NUPL1 nucleoporin like 1 13 24773665 AA769986 13q12.13 Hs.310453 Hs.719291 9

nucleus

nuclear pore

protein transport

membrane

mRNA transport

intracellular protein transmembrane transport

 
1560633_a_at D21S2089E D21S2089E 21   AY063453 21q21.1 Hs.473425 1    
220757_s_at UBXN6 UBX domain protein 6 19 -4396260 NM_025241 19p13 Hs.435255 Hs.661664 6

molecular_function

protein binding

cellular_component

nucleus

cytoplasm

centrosome

biological_process

modification-dependent protein catabolic process

 
224767_at 0.292 6.011 3.083 7.482e-03 0.376 -2.310 RPL37 ribosomal protein L37 5 -40867186 AL044126 5p13 Hs.558601 Hs.80545 12

structural constituent of ribosome

protein binding

intracellular

cytosol

ribosome

translational elongation

zinc ion binding

rRNA binding

cytosolic large ribosomal subunit

metal ion binding

Ribosome

1556588_at C15orf37 chromosome 15 open reading frame 37 15 78002167 AK091107 15q25.1 Hs.512015 2    
232591_s_at 0.285 3.859 2.313 3.507e-02 0.555 -3.612 TMEM30A transmembrane protein 30A 6 -76019357 AK022883 6q14.1 Hs.108530 7

membrane

integral to membrane

 
218595_s_at HEATR1 HEAT repeat containing 1 1 -234780593 NM_018072 1q43 Hs.708114 9

protein binding

nucleus

nucleolus

rRNA processing

ribonucleoprotein complex

 
205755_at ITIH3 inter-alpha (globulin) inhibitor H3 3 52803823 NM_002217 3p21.2-p21.1 Hs.76716 24

serine-type endopeptidase inhibitor activity

extracellular region

hyaluronan metabolic process

 
1552727_s_at ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 15 -98329165 AA022668 15q24 Hs.513200 5

metalloendopeptidase activity

extracellular region

proteinaceous extracellular matrix

proteolysis

peptidase activity

zinc ion binding

metal ion binding

 
206516_at -0.309 4.538 -2.531 2.288e-02 0.503 -3.255 AMH anti-Mullerian hormone 19 2200112 NM_000479 19p13.3 Hs.112432 75

urogenital system development

Mullerian duct regression

transforming growth factor beta receptor binding

hormone activity

extracellular region

extracellular space

cytoplasm

cell-cell signaling

gonadal mesoderm development

sex determination

sex differentiation

growth factor activity

cell differentiation

Cytokine-cytokine receptor interaction

TGF-beta signaling pathway

227476_at 0.342 6.861 2.230 4.124e-02 0.571 -3.745 LPGAT1 lysophosphatidylglycerol acyltransferase 1 1 -209983422 AW576195 1q32 Hs.497674 6

molecular_function

cytoplasm

endoplasmic reticulum

metabolic process

acyltransferase activity

phospholipid biosynthetic process

membrane

integral to membrane

transferase activity

 
1552362_a_at -0.439 6.237 -3.962 1.222e-03 0.234 -0.770 LEAP2 liver expressed antimicrobial peptide 2 5 132237256 NM_052971 5q31.1 Hs.337588 3

extracellular region

defense response to bacterium

 
212551_at CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 6 17501714 NM_006366 6p22.3 Hs.132902 7

actin binding

binding

plasma membrane

cytoskeleton organization

establishment or maintenance of cell polarity

signal transduction

activation of adenylate cyclase activity

 
201674_s_at -0.423 10.078 -2.629 1.882e-02 0.488 -3.091 AKAP1 A kinase (PRKA) anchor protein 1 17 52517551 BC000729 17q21-q23 Hs.463506 27

RNA binding

protein binding

cytoplasm

mitochondrion

mitochondrial outer membrane

membrane

integral to membrane

 
230082_at LOC100133660 hypothetical LOC100133660 3   AW137053          
209858_x_at 0.268 7.479 2.275 3.779e-02 0.564 -3.673 MPPE1 metallophosphoesterase 1 18 -11873471 BC002877 18p11.21 Hs.712666 8

membrane

integral to membrane

hydrolase activity

metal ion binding

 
242900_at ALG10B asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast) 12 36996823 BF244214 12q12 Hs.259305 5

plasma membrane

integral to membrane

transferase activity, transferring hexosyl groups

N-Glycan biosynthesis

Metabolic pathways

211282_x_at TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1 -6446757, -6443800 U94506 1p36.2 Hs.462529 30

receptor activity

tumor necrosis factor receptor activity

protein binding

extracellular region

cytosol

plasma membrane

integral to plasma membrane

cell surface receptor linked signal transduction

induction of apoptosis by extracellular signals

regulation of apoptosis

Cytokine-cytokine receptor interaction

202244_at PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 1 149638664 NM_002796 1q21 Hs.89545 46

threonine-type endopeptidase activity

nucleus

cytoplasm

centrosome

cytosol

proteasome core complex

cytoskeleton

peptidase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

proteolysis involved in cellular protein catabolic process

Proteasome

218820_at C14orf132 chromosome 14 open reading frame 132 14 95575414 NM_020215 14q32.2 Hs.6434 6

membrane

integral to membrane

 
212977_at CXCR7 chemokine (C-X-C motif) receptor 7 2 237143118 AI817041 2q37.3 Hs.471751 21

receptor activity

G-protein coupled receptor activity

protein binding

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

biological_process

integral to membrane

interspecies interaction between organisms

 
1562689_at -0.255 4.549 -2.448 2.695e-02 0.525 -3.392 LOC151484 hypothetical protein LOC151484 2   BC043555 2q37.1 Hs.559309 1    
213898_at -0.312 4.066 -2.879 1.134e-02 0.426 -2.663 RBM9 RNA binding motif protein 9 22 -34464728, -34464728 AW149379 22q13.1 Hs.282998 18

nucleotide binding

transcription corepressor activity

RNA binding

nucleus

cytoplasm

mRNA processing

transcription factor binding

RNA splicing

RNA metabolic process

negative regulation of transcription

estrogen receptor signaling pathway

regulation of cell proliferation

 
235754_at HFE hemochromatosis 6 26195487 AA088873 6p21.3 Hs.233325 592

antigen processing and presentation of peptide antigen via MHC class I

iron ion binding

protein binding

cytoplasm

early endosome

plasma membrane

integral to plasma membrane

protein complex assembly

ion transport

iron ion transport

cellular iron ion homeostasis

receptor-mediated endocytosis

immune response

antigen processing and presentation

cytoplasmic vesicle

MHC class I protein complex

apical part of cell

basal part of cell

perinuclear region of cytoplasm

recycling endosome

 
1554541_a_at -0.388 4.981 -3.730 1.968e-03 0.273 -1.174 GPRIN2 G protein regulated inducer of neurite outgrowth 2 10 46413551 BC011672 10q11.22 Hs.523375 7    
215035_at IGLV6-57 immunoglobulin lambda variable 6-57 22   AI952772 22q11.2 Hs.535668 6    
233093_s_at BIRC6 baculoviral IAP repeat-containing 6 2 32435599 AK023788 2p22-p21 Hs.150107 14

ubiquitin-protein ligase activity

cysteine-type endopeptidase inhibitor activity

protein binding

cellular_component

intracellular

membrane fraction

apoptosis

anti-apoptosis

positive regulation of cell proliferation

ligase activity

modification-dependent protein catabolic process

peptidase inhibitor activity

post-translational protein modification

regulation of protein metabolic process

Ubiquitin mediated proteolysis

1556134_a_at 1.511 7.294 5.367 7.471e-05 0.162 1.547 B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 3 184453725 BC013229 3q28 Hs.718506 7

intracellular

Golgi apparatus

protein amino acid glycosylation

multicellular organismal development

central nervous system development

galactosyltransferase activity

beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity

lipopolysaccharide N-acetylglucosaminyltransferase activity

glycolipid biosynthetic process

membrane

integral to membrane

transferase activity, transferring glycosyl groups

Glycosphingolipid biosynthesis - lacto and neolacto series

Metabolic pathways

210153_s_at 0.430 7.460 2.971 9.411e-03 0.401 -2.505 ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 18 46659432 M55905 18q21 6p25-p24 Hs.233119 24

malate dehydrogenase (decarboxylating) activity

binding

mitochondrion

mitochondrial matrix

malate metabolic process

electron carrier activity

oxidoreductase activity

malate dehydrogenase (oxaloacetate-decarboxylating) activity

metal ion binding

NAD or NADH binding

oxidation reduction

Pyruvate metabolism

Biosynthesis of phenylpropanoids

Biosynthesis of alkaloids derived from terpenoid and polyketide

229838_at 0.388 5.327 2.579 2.080e-02 0.497 -3.175 NUCB2 nucleobindin 2 11 17254861 AI377271 11p15.1-p14 Hs.654599 15

DNA binding

calcium ion binding

extracellular region

extracellular space

nucleus

nuclear outer membrane

cytoplasm

endoplasmic reticulum

ER-Golgi intermediate compartment

Golgi apparatus

cytosol

plasma membrane

 
240509_s_at 0.361 2.488 2.177 4.565e-02 0.581 -3.829 GREM2 gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis) 1 -238719495 BF064262 1q43 Hs.98206 9

cytokine activity

extracellular region

extracellular region

extracellular space

BMP signaling pathway

 
204725_s_at NCK1 NCK adaptor protein 1 3 138063762 NM_006153 3q21 Hs.477693 110

receptor binding

cytoplasm

endoplasmic reticulum

regulation of translation

actin filament organization

signal complex assembly

cytoskeletal adaptor activity

vesicle membrane

cell migration

protein domain specific binding

lamellipodium assembly

receptor signaling complex scaffold activity

positive regulation of actin filament polymerization

positive regulation of T cell proliferation

T cell activation

ErbB signaling pathway

Axon guidance

T cell receptor signaling pathway

Pathogenic Escherichia coli infection - EHEC

226050_at 0.906 6.706 2.600 1.991e-02 0.491 -3.138 TMCO3 transmembrane and coiled-coil domains 3 13 113193308 AL576117 13q34 Hs.317593 6

cation transport

antiporter activity

solute:hydrogen antiporter activity

membrane

integral to membrane

 
228891_at SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 9 -91181971, -91165525 N93399 9q22.2 Hs.494406 29

receptor activity

receptor binding

anti-apoptosis

immune response

cell adhesion

multicellular organismal development

nervous system development

membrane

integral to membrane

cell differentiation

positive regulation of axonogenesis

Axon guidance

220782_x_at -0.228 5.473 -2.295 3.633e-02 0.558 -3.641 KLK12 kallikrein-related peptidase 12 19 -56224159 NM_019598 19q13.3-q13.4 Hs.411572 13

serine-type endopeptidase activity

extracellular region

soluble fraction

proteolysis

peptidase activity

 
1554020_at 0.533 3.793 3.033 8.274e-03 0.387 -2.395 BICD1 bicaudal D homolog 1 (Drosophila) 12 32151451 BC010091 12p11.2-p11.1 Hs.505202 17

structural constituent of cytoskeleton

protein binding

Golgi apparatus

cytoskeleton

RNA processing

transport

intracellular mRNA localization

anatomical structure morphogenesis

 
232054_at 1.366 3.202 3.082 7.498e-03 0.376 -2.311 PCDH20 protocadherin 20 13 -60881819 AA040057 13q21 Hs.391781 9

calcium ion binding

protein binding

plasma membrane

cell adhesion

homophilic cell adhesion

integral to membrane

 
206435_at B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 12 -56305817 NM_001478 12q13.3 Hs.591019 11

ganglioside biosynthetic process

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity

membrane fraction

Golgi apparatus

carbohydrate metabolic process

glycosphingolipid metabolic process

spermatogenesis

membrane

integral to membrane

transferase activity, transferring hexosyl groups

lipid storage

integral to Golgi membrane

lipid glycosylation

Glycosphingolipid biosynthesis - ganglio series

Metabolic pathways

203574_at NFIL3 nuclear factor, interleukin 3 regulated 9 -93211147 NM_005384 9q22 Hs.79334 13

transcription factor activity

transcription corepressor activity

nucleus

regulation of transcription, DNA-dependent

transcription from RNA polymerase II promoter

immune response

sequence-specific DNA binding

protein dimerization activity

rhythmic process

 
203610_s_at 0.609 4.839 2.915 1.054e-02 0.418 -2.601 TRIM38 tripartite motif-containing 38 6 26071049 AI363270 6p21.3 Hs.584851 7

signal transducer activity

protein binding

cellular_component

intracellular

zinc ion binding

positive regulation of I-kappaB kinase/NF-kappaB cascade

metal ion binding

 
201936_s_at EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 1 -21005560 NM_003760 1p36.12 Hs.467084 19

RNA cap binding

translation initiation factor activity

protein binding

regulation of translational initiation

RNA metabolic process

eukaryotic translation initiation factor 4F complex

interspecies interaction between organisms

 
221766_s_at FAM46A family with sequence similarity 46, member A 6 -82512165 AW246673 6q14 Hs.10784 11    
212556_at -0.777 7.542 -3.367 4.164e-03 0.324 -1.811 SCRIB scribbled homolog (Drosophila) 8 -144945077 AI469403 8q24.3 Hs.436329 37

protein binding

cytoplasm

membrane

 
223321_s_at -0.270 6.496 -3.098 7.255e-03 0.375 -2.283 FGFRL1 fibroblast growth factor receptor-like 1 4 995609, 995759, 996251 AF312678 4p16 Hs.193326 15

regulation of cell growth

receptor activity

fibroblast growth factor receptor activity

protein binding

plasma membrane

negative regulation of cell proliferation

integral to membrane

 
210304_at -0.324 5.012 -3.205 5.812e-03 0.357 -2.095 PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 4 609362, 636965 BC000249 4p16.3 Hs.623810 Hs.654544 30

signal transduction

visual perception

phototransduction, visible light

detection of light stimulus

membrane

hydrolase activity

3',5'-cyclic-GMP phosphodiesterase activity

response to stimulus

 
1553007_a_at ODZ1 odz, odd Oz/ten-m homolog 1(Drosophila) X -123337436 NM_014253 Xq25 Hs.23796 Hs.537002 Hs.716649 13

extracellular region

integral to plasma membrane

immune response

signal transduction

nervous system development

heparin binding

negative regulation of cell proliferation

membrane

 
225651_at 0.373 7.266 2.247 3.987e-02 0.568 -3.717 UBE2E2 ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) 3 23219787 BF431962 3p24.2 Hs.475688 Hs.595802 14

nucleotide binding

ubiquitin-protein ligase activity

ATP binding

ligase activity

modification-dependent protein catabolic process

ISG15-protein conjugation

ISG15 ligase activity

regulation of protein metabolic process

Ubiquitin mediated proteolysis

206710_s_at 1.155 4.228 3.131 6.771e-03 0.368 -2.225 EPB41L3 erythrocyte membrane protein band 4.1-like 3 18 -5382387 NM_012307 18p11.32 Hs.213394 39

actin binding

structural molecule activity

cytoplasm

cytoskeleton

plasma membrane

cell-cell junction

biological_process

extrinsic to membrane

cortical actin cytoskeleton organization

Tight junction

218145_at TRIB3 tribbles homolog 3 (Drosophila) 20 309307 NM_021158 20p13-p12.2 Hs.516826 36

transcription corepressor activity

protein kinase activity

protein kinase inhibitor activity

protein binding

protein binding

ATP binding

nucleus

nucleolus

protein amino acid phosphorylation

negative regulation of protein kinase activity

apoptosis

response to stress

protein kinase binding

protein kinase binding

regulation of MAP kinase activity

regulation of transcription

 
235300_x_at RCHY1 ring finger and CHY zinc finger domain containing 1 4 -76623370 AW236209 4q21.1 Hs.48297 20

protein binding

nucleus

cytoplasm

zinc ion binding

metal ion binding

p53 signaling pathway

Ubiquitin mediated proteolysis

222532_at SRPRB signal recognition particle receptor, B subunit 3 135007366 BF983948 3q22.1 Hs.12152 10

nucleotide binding

receptor activity

protein binding

GTP binding

endoplasmic reticulum

membrane

integral to membrane

ribonucleoprotein complex

 
202390_s_at HTT huntingtin 4 3046205 NM_002111 4p16.3 Hs.518450 252

urea cycle

citrulline metabolic process

transcription corepressor activity

transporter activity

calcium channel regulator activity

protein binding

soluble fraction

nucleus

cytoplasm

Golgi apparatus

protein import into nucleus

ER to Golgi vesicle-mediated transport

anti-apoptosis

induction of apoptosis

mitochondrion organization

endoplasmic reticulum organization

dopamine receptor signaling pathway

spermatogenesis

gastrulation

brain development

cell aging

locomotory behavior

microtubule binding

axon cargo transport

associative learning

determination of adult lifespan

visual learning

pathogenesis

embryonic development

organ morphogenesis

anterior/posterior pattern formation

cytoplasmic membrane-bounded vesicle

endosome transport

inclusion body

lactate biosynthetic process from pyruvate

quinolinate biosynthetic process

striatum development

olfactory lobe development

neural plate formation

neurogenesis

insulin secretion

axon

social behavior

hormone metabolic process

negative regulation of neuron apoptosis

regulation of mitochondrial membrane permeability

vesicle transport along microtubule

regulation of synaptic plasticity

paraxial mesoderm formation

neuron development

diazepam binding

response to calcium ion

regulation of mitochondrial membrane potential

L-glutamate import

iron ion homeostasis

Huntington's disease

209654_at KIAA0947 KIAA0947 5 5475806 BC004902 5p15.32 Hs.449296 3    
211778_s_at OVOL2 ovo-like 2 (Drosophila) 20 -17952795 BC006148 20pter-q11.23 Hs.661013 Hs.710157 5

neural crest cell migration

neural fold formation

DNA binding

intracellular

nucleus

heart development

zinc ion binding

negative regulation of cell proliferation

dorsal/ventral pattern formation

regulation of transcription

negative regulation of transcription, DNA-dependent

positive regulation of transcription, DNA-dependent

metal ion binding

embryonic gut morphogenesis

 
1555399_a_at DUSP16 dual specificity phosphatase 16 12 -12520097 AY038927 12p13 Hs.536535 12

inactivation of MAPK activity

protein tyrosine phosphatase activity

protein binding

nucleus

cytoplasm

protein amino acid dephosphorylation

hydrolase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

MAPK export from nucleus

MAPK phosphatase export from nucleus, leptomycin B sensitive

MAPK signaling pathway

232652_x_at 0.356 7.547 2.570 2.116e-02 0.497 -3.189 SCAND1 SCAN domain containing 1 20 -34004959 AF207829 20q11.1-q11.23 Hs.584909 14

transcription factor activity

transcription coactivator activity

nucleus

regulation of transcription, DNA-dependent

identical protein binding

 
226856_at MUSTN1 musculoskeletal, embryonic nuclear protein 1 3 -52842176 BF793701 3p21.1 Hs.556077 1

nucleus

 
1557918_s_at -0.248 5.117 -2.348 3.279e-02 0.550 -3.556 SLC16A1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1) 1 -113255992 AU131482 1p12 Hs.75231 43

protein binding

membrane fraction

plasma membrane

transport

mevalonate transmembrane transporter activity

symporter activity

secondary active monocarboxylate transmembrane transporter activity

organic anion transport

mevalonate transport

integral to membrane

 
232922_s_at SLC17A9 solute carrier family 17, member 9 20 61054443 BG419965 20q13.33 Hs.512686 7

transporter activity

transport

exocytosis

membrane

integral to membrane

 
206605_at P11 26 serine protease 12 -46389794 NM_006025 12q13.1 Hs.997 7

scavenger receptor activity

extracellular region

extracellular space

cytoplasm

cytoplasm

plasma membrane

proteolysis

immune response

female pregnancy

growth factor activity

peptidase activity

serine-type peptidase activity

polysaccharide binding

 
232055_at SFXN1 sideroflexin 1 5 174838119 AA960991   Hs.369440 18

iron ion binding

protein binding

mitochondrion

mitochondrial inner membrane

cation transport

iron ion transport

cation transmembrane transporter activity

membrane

integral to membrane

erythrocyte differentiation

 
220349_s_at 0.436 7.377 3.024 8.437e-03 0.388 -2.412 ENGASE endo-beta-N-acetylglucosaminidase 17 74582613 NM_022759 17q25.3 Hs.29288 5

intracellular

cytoplasm

cytosol

metabolic process

hydrolase activity, acting on glycosyl bonds

mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity

Other glycan degradation

227002_at -0.385 8.112 -2.509 2.391e-02 0.509 -3.292 FAM78A family with sequence similarity 78, member A 9 -133123285 BF515132 9q34 Hs.143878 Hs.704076 5    
208718_at DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 22 -37209388, -37209388 Z97056 22q13.1 Hs.528305 Hs.665429 Hs.719084 28

nucleotide binding

RNA binding

RNA helicase activity

ATP binding

nucleus

RNA processing

ATP-dependent helicase activity

RNA-dependent ATPase activity

hydrolase activity

 
1563263_at PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 16 80370430 BC040927 16q24.1 Hs.413111 63

follicular B cell differentiation

phosphoinositide phospholipase C activity

signal transducer activity

calcium ion binding

protein binding

plasma membrane

intracellular signaling cascade

phospholipid catabolic process

regulation of gene expression

lipid catabolic process

hydrolase activity

activation of store-operated calcium channel activity

response to lipopolysaccharide

inositol trisphosphate biosynthetic process

negative regulation of programmed cell death

T cell receptor signaling pathway

Inositol phosphate metabolism

Metabolic pathways

ErbB signaling pathway

Calcium signaling pathway

Phosphatidylinositol signaling system

VEGF signaling pathway

Natural killer cell mediated cytotoxicity

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Fc gamma R-mediated phagocytosis

Leukocyte transendothelial migration

Neurotrophin signaling pathway

Vibrio cholerae infection

Epithelial cell signaling in Helicobacter pylori infection

Pathways in cancer

Glioma

Non-small cell lung cancer

208366_at -0.288 3.531 -2.256 3.919e-02 0.567 -3.703 PCDH11X protocadherin 11 X-linked X 90920959, 90976314, 90976314 NM_014522 Xq21.3 Hs.655673 16

calcium ion binding

protein binding

plasma membrane

integral to plasma membrane

cell adhesion

homophilic cell adhesion

 
219408_at 0.318 6.260 2.363 3.183e-02 0.544 -3.531 PRMT7 protein arginine methyltransferase 7 16 66902445 NM_019023 16q22.1 Hs.712584 9

spliceosomal snRNP biogenesis

nucleus

cytoplasm

cytosol

genetic imprinting

S-adenosylmethionine-dependent methyltransferase activity

[myelin basic protein]-arginine N-methyltransferase activity

chromatin modification

transferase activity

peptidyl-arginine methylation

cell differentiation

histone arginine methylation

protein-arginine omega-N monomethyltransferase activity

protein-arginine omega-N symmetric methyltransferase activity

protein-arginine omega-N symmetric methyltransferase activity

histone binding

ribonucleoprotein binding

DNA methylation during gametogenesis

regulation of protein binding

histone methyltransferase activity (H4-R3 specific)

regulation of transcription

 
213353_at ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 17 -64752170, -64752170 BF693921 17q24.3 Hs.421474 11

nucleotide binding

ATP binding

lysosome

endosome

Golgi apparatus

transport

membrane

integral to membrane

ATPase activity

ABC transporters

203192_at ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 2 -219782737 NM_005689 2q36 Hs.107911 15

nucleotide binding

ATP binding

mitochondrion

mitochondrial envelope

mitochondrial outer membrane

transport

cellular iron ion homeostasis

membrane

integral to membrane

ATPase activity

ATPase activity, coupled to transmembrane movement of substances

ATP-binding cassette (ABC) transporter complex

ABC transporters

226464_at C3orf58 chromosome 3 open reading frame 58 3 145173329, 145174856 BE348597 3q24 Hs.288954 5

extracellular region

 
206561_s_at AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 7 133862883 NM_020299 7q33 Hs.116724 30

aldo-keto reductase activity

protein binding

cellular_component

cytoplasm

cellular aldehyde metabolic process

digestion

steroid metabolic process

oxidoreductase activity

oxidation reduction

Fructose and mannose metabolism

Bisphenol A degradation

Linoleic acid metabolism

Tetrachloroethene degradation

Butanoate metabolism

Metabolic pathways

232599_at EXOC6 exocyst complex component 6 10 94584449, 94598204 AF220217 10q23.33 Hs.655657 8

exocyst

vesicle docking during exocytosis

protein transport

 
224697_at 0.285 5.988 2.479 2.537e-02 0.515 -3.342 DCAF5 DDB1 and CUL4 associated factor 5 14 -68587390 AI568478 14q23-q24.1 Hs.509780 6    
201556_s_at -0.510 5.130 -4.092 9.360e-04 0.222 -0.544 VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 17 -8003189 BC002737 17p13.1 Hs.25348 66

protein binding

integral to plasma membrane

membrane

vesicle-mediated transport

synaptosome

cell junction

cytoplasmic vesicle

synapse

SNARE interactions in vesicular transport

221597_s_at 0.381 6.834 2.579 2.079e-02 0.497 -3.175 TMEM208 transmembrane protein 208 16 65818516 BC003080 16q22.1 Hs.433203 2

membrane

integral to membrane

 
215268_at KIAA0754 KIAA0754 1 39647762 AW663712 1p34.3 Hs.658760 1    
202595_s_at 0.368 6.046 2.908 1.070e-02 0.420 -2.613 LEPROTL1 leptin receptor overlapping transcript-like 1 8 30072463, 30072463 AF161461 8p21.2-p21.1 Hs.146585 8

membrane

integral to membrane

 
218350_s_at -0.571 6.782 -3.460 3.434e-03 0.308 -1.647 GMNN geminin, DNA replication inhibitor 6 24883142 NM_015895 6p22.3 Hs.234896 40

protein binding

nucleoplasm

negative regulation of DNA replication

negative regulation of cell cycle

 
205395_s_at MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 11 -93790114 NM_005590 11q21 Hs.192649 107

single-stranded DNA specific endodeoxyribonuclease activity

regulation of mitotic recombination

DNA binding

double-stranded DNA binding

nucleus

nucleoplasm

nucleolus

double-strand break repair via nonhomologous end joining

response to DNA damage stimulus

telomere maintenance via telomerase

meiosis

reciprocal meiotic recombination

protein C-terminus binding

3'-5' exonuclease activity

hydrolase activity

manganese ion binding

Homologous recombination

Non-homologous end-joining

240342_at TRIM61 tripartite motif-containing 61 4 -166095049 BF508746 4q32.3 Hs.654633 4

protein binding

intracellular

zinc ion binding

metal ion binding

 
233632_s_at XRN1 5'-3' exoribonuclease 1 3 -143508138 AL117516 3q23 Hs.435103 12

DNA binding

RNA binding

protein binding

intracellular

cytoplasm

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

5'-3' exonuclease activity

hydrolase activity

RNA degradation

206235_at 0.509 4.536 3.181 6.110e-03 0.360 -2.137 LIG4 ligase IV, DNA, ATP-dependent 13 -107657792, -107657792, -107657792 NM_002312 13q33-q34 Hs.166091 82

single strand break repair

nucleotide binding

magnesium ion binding

condensed chromosome

in utero embryonic development

pro-B cell differentiation

DNA binding

DNA ligase (ATP) activity

ATP binding

intracellular

nucleus

cytoplasm

plasma membrane

focal adhesion

DNA-dependent protein kinase-DNA ligase 4 complex

DNA replication

nucleotide-excision repair, DNA gap filling

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

response to DNA damage stimulus

cell cycle

central nervous system development

protein C-terminus binding

cell proliferation

response to X-ray

response to gamma radiation

ligase activity

provirus integration

initiation of viral infection

DNA ligase IV complex

DNA ligase IV complex

T cell differentiation in the thymus

immunoglobulin V(D)J recombination

T cell receptor V(D)J recombination

somatic stem cell maintenance

negative regulation of neuron apoptosis

isotype switching

positive regulation of fibroblast proliferation

positive regulation of neurogenesis

DNA ligation during DNA recombination

DNA ligation during DNA repair

DNA ligation during DNA repair

chromosome organization

cell division

Non-homologous end-joining

218067_s_at ARGLU1 arginine and glutamate rich 1 13 -105993662 NM_018011 13q33.3 Hs.508644 Hs.701016 3    
1570025_at -1.128 5.639 -6.931 4.451e-06 0.039 3.742 TACC2 transforming, acidic coiled-coil containing protein 2 10 123738678, 123913094 BC010219 10q26 Hs.501252 Hs.713875 18

protein binding

nucleus

cytoplasm

centrosome

nuclear hormone receptor binding

 
200597_at EIF3A eukaryotic translation initiation factor 3, subunit A 10 -120784530 AI123320 10q26 Hs.523299 38

formation of translation initiation complex

translation initiation factor activity

translation initiation factor activity

structural molecule activity

protein binding

nucleus

cytoplasm

cytosol

eukaryotic translation initiation factor 3 complex

 
215649_s_at MVK mevalonate kinase 12 108495882 AF217536 12q24 Hs.130607 42

nucleotide binding

mevalonate kinase activity

ATP binding

cytoplasm

peroxisome

cholesterol biosynthetic process

metabolic process

isoprenoid biosynthetic process

phosphorylation

transferase activity

identical protein binding

Terpenoid backbone biosynthesis

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

208315_x_at TRAF3 TNF receptor-associated factor 3 14 102313568 NM_003300 14q32.32 Hs.510528 99

signal transducer activity

protein binding

cytoplasm

induction of apoptosis

signal transduction

zinc ion binding

regulation of apoptosis

metal ion binding

Toll-like receptor signaling pathway

RIG-I-like receptor signaling pathway

Pathways in cancer

Small cell lung cancer

201428_at CLDN4 claudin 4 7 72883128 NM_001305 7q11.23 Hs.647036 Hs.699253 Hs.718794 55

transmembrane receptor activity

structural molecule activity

plasma membrane

integral to plasma membrane

tight junction

pathogenesis

calcium-independent cell-cell adhesion

cell junction

identical protein binding

Cell adhesion molecules (CAMs)

Tight junction

Leukocyte transendothelial migration

206020_at SOCS6 suppressor of cytokine signaling 6 18 66107116 NM_016387 18q22.2 Hs.44439 13

protein binding

cytoplasm

defense response

intracellular signaling cascade

JAK-STAT cascade

negative regulation of signal transduction

modification-dependent protein catabolic process

regulation of growth

 
211359_s_at OPRM1 opioid receptor, mu 1 6 154373328, 154402135, 154402135, 154402135, 154402135, 154402135, 154402135, 154402135, 154402238, 154449334 U12569 6q24-q25 Hs.2353 192

receptor activity

G-protein coupled receptor activity

mu-opioid receptor activity

endoplasmic reticulum

Golgi apparatus

plasma membrane

integral to plasma membrane

signal transduction

G-protein signaling, coupled to cyclic nucleotide second messenger

sensory perception

behavior

negative regulation of cell proliferation

Neuroactive ligand-receptor interaction

1555736_a_at 0.794 6.524 2.293 3.650e-02 0.559 -3.644 AGTRAP angiotensin II receptor-associated protein 1 11718728 AF165187 1p36.22 Hs.464438 14

protein binding

endoplasmic reticulum

Golgi apparatus

membrane

integral to membrane

cytoplasmic vesicle

 
217227_x_at IGL@ immunoglobulin lambda locus 22   X93006 22q11.1-q11.2 Hs.449585 Hs.561078 20    
204376_at VPRBP Vpr (HIV-1) binding protein 3 -51408337 NM_014703 3p21.2 Hs.716623 14

binding

cytoplasm

modification-dependent protein catabolic process

interspecies interaction between organisms

 
214797_s_at PCTK3 PCTAIRE protein kinase 3 1 203740349 BC000281 1q31-q32 Hs.445402 13

nucleotide binding

cyclin-dependent protein kinase activity

signal transducer activity

protein binding

ATP binding

cellular_component

protein amino acid phosphorylation

signal transduction

transferase activity

 
225639_at SKAP2 src kinase associated phosphoprotein 2 7 -26673212 N21390 7p21-p15 Hs.200770 Hs.644804 19

SH3/SH2 adaptor activity

cytoplasm

plasma membrane

protein complex assembly

signal transduction

negative regulation of cell proliferation

B cell activation

 
219863_at -0.313 4.663 -2.275 3.776e-02 0.564 -3.673 HERC5 hect domain and RLD 5 4 89597290 NM_016323 4q22.1 Hs.26663 10

regulation of cyclin-dependent protein kinase activity

intracellular

cytoplasm

protein modification process

ligase activity

acid-amino acid ligase activity

modification-dependent protein catabolic process

perinuclear region of cytoplasm

 
236064_at SLC25A35 solute carrier family 25, member 35 17 -8131806 AW966184 17p13.1 Hs.118918 3

binding

mitochondrion

mitochondrial inner membrane

transport

membrane

integral to membrane

 
212429_s_at GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa 2 -27402224 AW194657 2p23.3 Hs.75782 18

transcription factor TFIIIC complex

DNA binding

RNA polymerase III transcription factor activity

protein binding

nucleus

mitochondrion

peroxisome

transcription, DNA-dependent

oxygen and reactive oxygen species metabolic process

5S class rRNA transcription

tRNA transcription from RNA polymerase III promoter

 
232810_at AIG1 androgen-induced 1 6 143423715 AK001347 6q24.2 Hs.567501 8

membrane

integral to membrane

 
203724_s_at RUFY3 RUN and FYVE domain containing 3 4 71789517, 71806559, 71806559 NM_014961 4q13.3 Hs.713172 8

multicellular organismal development

nervous system development

cell differentiation

filopodium

growth cone

negative regulation of axonogenesis

 
227123_at -0.266 3.818 -2.564 2.140e-02 0.497 -3.199 RAB3B RAB3B, member RAS oncogene family 1 -52157422 AU156710 1p32-p31 Hs.123072 15

nucleotide binding

GTPase activity

protein binding

GTP binding

plasma membrane

small GTPase mediated signal transduction

synaptic vesicle

protein transport

regulation of exocytosis

peptidyl-cysteine methylation

Tight junction

203785_s_at 0.568 6.058 3.735 1.948e-03 0.273 -1.165 DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 16 -66612674 NM_018380 16q22.1 Hs.458313 9

nucleotide binding

RNA binding

helicase activity

ATP binding

nucleus

mitochondrion

ATP-dependent helicase activity

hydrolase activity

mitochondrial nucleoid

 
212186_at 0.481 6.822 3.271 5.072e-03 0.345 -1.979 ACACA acetyl-Coenzyme A carboxylase alpha 17 -32516039, -32516039, -32516039 BE855983 17q21 Hs.160556 35

nucleotide binding

acetyl-CoA carboxylase activity

biotin carboxylase activity

protein binding

ATP binding

cytoplasm

fatty acid biosynthetic process

metabolic process

biotin binding

ligase activity

manganese ion binding

metal ion binding

Fatty acid biosynthesis

Pyruvate metabolism

Propanoate metabolism

Metabolic pathways

Insulin signaling pathway

1553960_at 0.696 7.328 3.290 4.881e-03 0.341 -1.946 SNX21 sorting nexin family member 21 20 43895876 CA447177 20q13.12 Hs.472854 8

protein binding

cell communication

protein transport

phosphoinositide binding

 
230363_s_at INPP5F inositol polyphosphate-5-phosphatase F 10 121475598, 121475598, 121568775 BE858808 10q26.11 Hs.369755 7

hydrolase activity

 
227322_s_at 0.349 8.389 2.838 1.234e-02 0.427 -2.734 BCCIP BRCA2 and CDKN1A interacting protein 10 127502093, 127502093, 127502093 BE464077 10q26.1 Hs.370292 Hs.715543 31

regulation of cyclin-dependent protein kinase activity

protein binding

nucleus

DNA repair

response to DNA damage stimulus

cell cycle

 
208674_x_at DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase 1 -20850846 BC002594 1p36.1 Hs.523145 12

dolichyl-diphosphooligosaccharide-protein glycotransferase activity

protein binding

endoplasmic reticulum

microsome

protein amino acid terminal N-glycosylation

oligosaccharyltransferase complex

membrane

integral to membrane

transferase activity

protein amino acid N-linked glycosylation via asparagine

response to cytokine stimulus

T cell activation

N-Glycan biosynthesis

Metabolic pathways

212845_at SAMD4A sterile alpha motif domain containing 4A 14 54104386, 54291255 AB028976 14q22.2 Hs.98259 4

cytoplasm

synaptosome

translation repressor activity

dendrite

positive regulation of translation

 
212010_s_at CDV3 CDV3 homolog (mouse) 3 134775123, 134775990 AK025647 3q22.1 Hs.518265 11

molecular_function

cellular_component

cytoplasm

cell proliferation

 
242722_at 0.471 6.194 2.836 1.239e-02 0.427 -2.737 LMO7 LIM domain 7 13 75092570, 75232797 AA100793 13q22.2 Hs.207631 18

ubiquitin ligase complex

ubiquitin-protein ligase activity

protein binding

nucleus

cytoplasm

zinc ion binding

protein ubiquitination

metal ion binding

Adherens junction

215690_x_at 0.263 8.023 2.201 4.358e-02 0.578 -3.791 GPAA1 glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) 8 145209511 AL157437 8q24.3 Hs.627962 16

GPI-anchor transamidase activity

protein binding

endoplasmic reticulum

protein complex assembly

protein retention in ER lumen

tubulin binding

membrane

integral to membrane

attachment of GPI anchor to protein

attachment of GPI anchor to protein

attachment of GPI anchor to protein

GPI anchor binding

GPI-anchor transamidase complex

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

Metabolic pathways

1568978_s_at C11orf21 chromosome 11 open reading frame 21 11 -2274082 BM547346 11p15.5 Hs.559181 2

cytoplasm

 
1563082_at LOC285045 hypothetical LOC285045 2 32904013, 32961269, 32961371 BC040883 2p22.3 Hs.434660 2    
226350_at CHML choroideremia-like (Rab escort protein 2) 1 -239858789 AU155565 1q42-qter Hs.654545 17

Rab geranylgeranyltransferase activity

GTPase activator activity

Rab-protein geranylgeranyltransferase complex

intracellular protein transport

visual perception

regulation of GTPase activity

 
233523_at -0.349 4.436 -3.027 8.388e-03 0.388 -2.407 C20orf186 chromosome 20 open reading frame 186 20 31132978 AL121756 20q11.21 Hs.38961 4

extracellular region

cytoplasm

lipid binding

 
225921_at NIN ninein (GSK3B interacting protein) 14 -50263700, -50262296, -50262296, -50256230 AL359571 14q22.1 Hs.310429 23

nucleotide binding

protein binding

GTP binding

centrosome

microtubule

centrosome localization

 
205116_at 0.726 6.684 4.849 2.044e-04 0.172 0.726 LAMA2 laminin, alpha 2 6 129245978 NM_000426 6q22-q23 Hs.200841 40

receptor binding

structural molecule activity

extracellular region

basal lamina

laminin-1 complex

muscle organ development

regulation of cell adhesion

regulation of cell migration

positive regulation of synaptic transmission, cholinergic

sarcolemma

regulation of embryonic development

Focal adhesion

ECM-receptor interaction

Pathways in cancer

Small cell lung cancer

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

206717_at MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 17 -10234366 NM_002472 17p13.1 Hs.700484 10

nucleotide binding

motor activity

actin binding

calmodulin binding

ATP binding

cytoplasm

striated muscle thick filament

striated muscle contraction

structural constituent of muscle

myosin complex

myofibril

Tight junction

1555865_at 0.622 5.315 2.978 9.264e-03 0.400 -2.491 LOC255512 hypothetical protein LOC255512 11   R67325 11p15.5 Hs.588291 1    
216083_s_at -0.315 5.442 -2.760 1.444e-02 0.447 -2.867 NEU3 sialidase 3 (membrane sialidase) 11 74377597 AK022450 11q13.5 Hs.191074 25

exo-alpha-sialidase activity

plasma membrane

integral to plasma membrane

carbohydrate metabolic process

ganglioside catabolic process

metabolic process

hydrolase activity, acting on glycosyl bonds

Other glycan degradation

Sphingolipid metabolism

1552611_a_at JAK1 Janus kinase 1 1 -65071493 AL555086 1p32.3-p31.3 Hs.207538 118

nucleotide binding

non-membrane spanning protein tyrosine kinase activity

Janus kinase activity

growth hormone receptor binding

protein binding

ATP binding

nucleus

cytoplasm

cytoskeleton

enzyme linked receptor protein signaling pathway

protein kinase cascade

membrane

transferase activity

peptidyl-tyrosine phosphorylation

cytokine-mediated signaling pathway

response to antibiotic

Jak-STAT signaling pathway

Pathways in cancer

Pancreatic cancer

241343_at RNASEH1 ribonuclease H1 2 -3570565 BF127479 2p25 Hs.568006 20

magnesium ion binding

RNA binding

endonuclease activity

ribonuclease H activity

ribonuclease activity

cytoplasm

mitochondrion

RNA catabolic process

hydrolase activity

DNA replication

217810_x_at LARS leucyl-tRNA synthetase 5 -145472781 NM_020117 5q32 Hs.432674 20

nucleotide binding

leucine-tRNA ligase activity

ATP binding

cytoplasm

leucyl-tRNA aminoacylation

ligase activity

Valine, leucine and isoleucine biosynthesis

Aminoacyl-tRNA biosynthesis

227285_at C1orf51 chromosome 1 open reading frame 51 1 148521852 AW080835 1q21.2 Hs.54680 4    
223636_at ZMYND12 zinc finger, MYND-type containing 12 1 -42668589 AL136858 1p34.2 Hs.294009 5

binding

intracellular

zinc ion binding

metal ion binding

 
215918_s_at SPTBN1 spectrin, beta, non-erythrocytic 1 2 54536957, 54639034 AA131826 2p21 Hs.503178 Hs.705692 46

actin binding

structural constituent of cytoskeleton

calmodulin binding

nucleus

nucleolus

cytoplasm

plasma membrane

common-partner SMAD protein phosphorylation

SMAD protein nuclear translocation

spectrin

cortical cytoskeleton

M band

actin filament capping

 
222142_at 0.457 3.687 2.435 2.765e-02 0.526 -3.413 CYLD cylindromatosis (turban tumor syndrome) 16 49333461, 49333529 AK024212 16q12.1 Hs.578973 54

structural constituent of ribosome

ubiquitin thiolesterase activity

intracellular

cytoplasm

ribosome

cytoskeleton

translation

ubiquitin-dependent protein catabolic process

cell cycle

peptidase activity

cysteine-type peptidase activity

perinuclear region of cytoplasm

RIG-I-like receptor signaling pathway

219625_s_at COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 5 -74702683, -74702683 NM_005713 5q13.3 Hs.270437 26

protein kinase activity

protein binding

cellular_component

cytoplasm

endoplasmic reticulum

Golgi apparatus

protein amino acid phosphorylation

lipid transport

immune response

 
207711_at C20orf117 chromosome 20 open reading frame 117 20 -34839258 NM_015377 20q11.23 Hs.460807 Hs.719179 8    
227707_at -0.407 5.074 -2.794 1.349e-02 0.437 -2.810 MYLIP myosin regulatory light chain interacting protein 6 16237295 AW027183 6p23-p22.3 Hs.484738 10

ubiquitin-protein ligase activity

intracellular

cytoplasm

cytoskeleton

cell motion

nervous system development

cytoskeletal protein binding

zinc ion binding

protein ubiquitination

ligase activity

extrinsic to membrane

modification-dependent protein catabolic process

metal ion binding

 
204022_at WWP2 WW domain containing E3 ubiquitin protein ligase 2 16 68353774, 68353774, 68516401 AI668780 16q22.1 Hs.408458 20

ubiquitin ligase complex

ubiquitin-protein ligase activity

protein binding

intracellular

protein modification process

negative regulation of gene expression

protein ubiquitination

ligase activity

acid-amino acid ligase activity

modification-dependent protein catabolic process

negative regulation of transporter activity

interspecies interaction between organisms

entry of virus into host cell

negative regulation of protein transport

Ubiquitin mediated proteolysis

206421_s_at -0.262 3.939 -3.042 8.125e-03 0.387 -2.380 SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 18 59571256, 59593591 NM_003784 18q21.33 Hs.138202 17

serine-type endopeptidase inhibitor activity

cytoplasm

peptidase inhibitor activity

 
202966_at 0.562 3.606 3.491 3.225e-03 0.306 -1.594 CAPN6 calpain 6 X -110374986 NM_014289 Xq23 Hs.496593 8

calcium-dependent cysteine-type endopeptidase activity

intracellular

proteolysis

 
208233_at PDPN podoplanin 1 13782838, 13784553 NM_013317 1p36.21 Hs.468675 48

cell morphogenesis

ruffle

lymphangiogenesis

plasma membrane

integral to plasma membrane

prostaglandin metabolic process

water transport

cell cycle

signal transduction

multicellular organismal development

cell proliferation

regulation of cell shape

folic acid transporter activity

amino acid transmembrane transporter activity

water channel activity

folic acid transport

cell-cell adhesion

lamellipodium

filopodium

positive regulation of cell migration

tube morphogenesis

lung alveolus development

 
207771_at -0.286 5.648 -3.287 4.908e-03 0.341 -1.951 SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 16 31401939 NM_003041 16p12-p11 Hs.709195 9

transporter activity

low-affinity glucose:sodium symporter activity

carbohydrate metabolic process

ion transport

sodium ion transport

carbohydrate transport

symporter activity

glucose transport

membrane

integral to membrane

sodium ion binding

brush border membrane

 
201648_at 0.362 9.116 2.295 3.637e-02 0.559 -3.642 JAK1 Janus kinase 1 1 -65071493 AL039831 1p32.3-p31.3 Hs.207538 118

nucleotide binding

non-membrane spanning protein tyrosine kinase activity

Janus kinase activity

growth hormone receptor binding

protein binding

ATP binding

nucleus

cytoplasm

cytoskeleton

enzyme linked receptor protein signaling pathway

protein kinase cascade

membrane

transferase activity

peptidyl-tyrosine phosphorylation

cytokine-mediated signaling pathway

response to antibiotic

Jak-STAT signaling pathway

Pathways in cancer

Pancreatic cancer

218371_s_at PSPC1 paraspeckle component 1 13 -19175008, -19146895 NM_018282 13q12.11 Hs.213198 9

nucleotide binding

RNA binding

protein binding

nucleus

nucleolus

cytoplasm

nuclear matrix

regulation of transcription

 
213369_at PCDH21 protocadherin 21 10 85944496 AI825832 10q22.1-q22.3 Hs.137556 3

receptor activity

calcium ion binding

protein binding

plasma membrane

integral to plasma membrane

cell adhesion

homophilic cell adhesion

photoreceptor cell maintenance

response to stimulus

 
226578_s_at -0.263 5.770 -2.175 4.583e-02 0.581 -3.832 DUSP1 dual specificity phosphatase 1 5 -172127706 AW024420 5q34 Hs.171695 73

non-membrane spanning protein tyrosine phosphatase activity

protein binding

protein amino acid dephosphorylation

response to oxidative stress

cell cycle

intracellular signaling cascade

hydrolase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

MAPK signaling pathway

226567_at USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 18 148482 BG283995 18p11.32 Hs.464416 Hs.707058 15

cysteine-type endopeptidase activity

ubiquitin thiolesterase activity

ubiquitin-specific protease activity

cytoplasm

ubiquitin-dependent protein catabolic process

tRNA guanylyltransferase activity

peptidase activity

 
206219_s_at -0.283 3.736 -2.711 1.596e-02 0.459 -2.952 VAV1 vav 1 guanine nucleotide exchange factor 19 6723721 NM_005428 19p13.2 Hs.116237 134

transcription factor activity

guanyl-nucleotide exchange factor activity

protein binding

intracellular

phagocytosis

immune response

integrin-mediated signaling pathway

intracellular signaling cascade

zinc ion binding

diacylglycerol binding

Rac guanyl-nucleotide exchange factor activity

regulation of Rho protein signal transduction

T cell activation

regulation of GTPase activity

positive regulation of cell adhesion

metal ion binding

Chemokine signaling pathway

Focal adhesion

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Fc gamma R-mediated phagocytosis

Leukocyte transendothelial migration

Regulation of actin cytoskeleton

218584_at 0.351 6.253 2.961 9.592e-03 0.405 -2.521 TCTN1 tectonic family member 1 12 109536262 NM_024549 12q24.11 Hs.211511 Hs.694390 5

extracellular region

multicellular organismal development

 
207180_s_at 0.319 7.429 2.725 1.549e-02 0.458 -2.927 HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 11 20341806, 20341822, 20341864, 20341978, 20342262 NM_006410 11p15.1 Hs.90753 31

RNA polymerase II transcription factor activity

transcription coactivator activity

protein binding

nucleus

nuclear envelope

cytoplasm

regulation of transcription from RNA polymerase II promoter

anti-apoptosis

induction of apoptosis

multicellular organismal development

oxidoreductase activity

cell differentiation

regulation of apoptosis

interspecies interaction between organisms

regulation of angiogenesis

nuclear import

oxidation reduction

 
214659_x_at 0.505 6.421 2.230 4.123e-02 0.571 -3.745 YLPM1 YLP motif containing 1 14 74299821 AC007956 14q24.3 Hs.531111 11

molecular_function

cellular_component

nucleus

biological_process

nuclear speck

 
235054_at 0.414 6.579 2.764 1.433e-02 0.447 -2.861 NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 3 132583396 BF941983 3q22.1 Hs.591313 5

magnesium ion binding

RNA binding

nucleus

nucleoplasm

nucleolus

hydrolase activity

manganese ion binding

 
236860_at NPY6R neuropeptide Y receptor Y6 (pseudogene) 5 137171360 BF968482 5q31 Hs.643466 Hs.713225 4

peptide YY receptor activity

receptor activity

G-protein coupled receptor activity

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

membrane

 
226828_s_at HEYL hairy/enhancer-of-split related with YRPW motif-like 1 -39861689 AL040198 1p34.3 Hs.472566 10

transcription factor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

Notch signaling pathway

multicellular organismal development

nervous system development

 
224614_at 0.355 6.007 2.488 2.492e-02 0.513 -3.327 DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 16 -65312299 AK024863 16q22.1 Hs.369068 10

nucleotide binding

motor activity

ATP binding

cytoplasmic dynein complex

microtubule

 
201662_s_at ACSL3 acyl-CoA synthetase long-chain family member 3 2 223433975 D89053 2q34-q35 Hs.655772 20

nucleotide binding

magnesium ion binding

fatty-acyl-CoA synthase activity

long-chain-fatty-acid-CoA ligase activity

protein binding

ATP binding

mitochondrion

mitochondrial outer membrane

peroxisome

endoplasmic reticulum

microsome

lipid metabolic process

fatty acid metabolic process

metabolic process

membrane

integral to membrane

ligase activity

Fatty acid metabolism

Metabolic pathways

PPAR signaling pathway

Adipocytokine signaling pathway

1560069_at PLEKHM3 pleckstrin homology domain containing, family M, member 3 2 -208394257 BC020812 2q33.3 Hs.159188 Hs.709906 3

intracellular signaling cascade

zinc ion binding

diacylglycerol binding

metal ion binding

 
212480_at 0.267 6.843 3.022 8.473e-03 0.388 -2.415 CYTSA cytospin A 22 22996785 AB002374 22q11.23 Hs.474384 6

cell cycle

cell division

 
221959_at 0.348 5.923 2.936 1.010e-02 0.415 -2.564 FAM110B family with sequence similarity 110, member B 8 59069666 BE672313 8q12.1 Hs.154652 7

cytoplasm

mitochondrion

centrosome

 
211670_x_at SSX3 synovial sarcoma, X breakpoint 3 X -48092637, -48090806 S82471 Xp11.23 Hs.558445 7

nucleic acid binding

intracellular

nucleus

regulation of transcription, DNA-dependent

 
233535_at -0.270 4.652 -2.404 2.937e-02 0.536 -3.464 ATP13A4 ATPase type 13A4 3 -194602559 AL512736 3q29 Hs.674423 4

nucleotide binding

magnesium ion binding

ATP binding

ATP biosynthetic process

cation transport

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

membrane

integral to membrane

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

ATPase activity

 
206993_at 0.769 7.515 2.981 9.221e-03 0.400 -2.487 ATP5S ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) 14 49848796, 49848796 NM_015684 14q21.3 Hs.438489 12

mitochondrion

mitochondrial inner membrane

ATP biosynthetic process

ion transport

hydrogen ion transmembrane transporter activity

proton transport

membrane

proton-transporting ATP synthase complex, coupling factor F(o)

 
225297_at 0.580 6.442 2.373 3.121e-02 0.543 -3.515 HAUS1 HAUS augmin-like complex, subunit 1 18 41938295 AV715391 18q21.1 Hs.436617 7

cytoplasm

centrosome

spindle

microtubule

cell cycle

mitosis

cell division

HAUS complex

 
203223_at RABEP1 rabaptin, RAB GTPase binding effector protein 1 17 5126281 NM_004703 17p13.2 Hs.584784 Hs.592121 19

GTPase activator activity

protein binding

cytoplasm

early endosome

endocytosis

apoptosis

membrane fusion

growth factor activity

protein transport

recycling endosome

Endocytosis

223652_at AS3MT arsenic (+3 oxidation state) methyltransferase 10 104619199 AF226730 10q24.32 Hs.34492 24

soluble fraction

cytoplasm

cytosol

metabolic process

methyltransferase activity

toxin metabolic process

transferase activity

arsonoacetate metabolic process

arsenite methyltransferase activity

methylarsonite methyltransferase activity

response to arsenic

 
217995_at 0.364 9.138 2.248 3.982e-02 0.568 -3.717 SQRDL sulfide quinone reductase-like (yeast) 15 43714547 NM_021199 15q15 Hs.511251 6

mitochondrion

mitochondrial inner membrane

oxidoreductase activity

oxidation reduction

 
204260_at 2.511 4.431 3.259 5.205e-03 0.348 -2.001 CHGB chromogranin B (secretogranin 1) 20 5839973 NM_001819 20pter-p12 Hs.516874 35

hormone activity

protein binding

extracellular region

 
205249_at EGR2 early growth response 2 10 -64241765, -64241765 NM_000399 10q21.1 Hs.1395 41

transcription factor activity

protein binding

intracellular

nucleus

regulation of transcription, DNA-dependent

learning or memory

rhythmic behavior

motor axon guidance

zinc ion binding

Schwann cell differentiation

rhombomere 3 development

facial nerve structural organization

rhombomere 3 formation

rhombomere 5 formation

regulation of ossification

response to insulin stimulus

brain segmentation

myelination

positive regulation of transcription from RNA polymerase II promoter

metal ion binding

regulation of neuronal synaptic plasticity

 
237785_at ASB14 ankyrin repeat and SOCS box-containing 14 3 -57277418, -57277418 AI806707 3p21.1 Hs.665154 Hs.703052 4

intracellular signaling cascade

 
232432_s_at 0.491 4.678 2.979 9.253e-03 0.400 -2.490 SLC30A5 solute carrier family 30 (zinc transporter), member 5 5 68425573, 68425637 AK022818 5q12.1 Hs.631975 10

zinc ion transmembrane transporter activity

membrane fraction

Golgi apparatus

integral to plasma membrane

cation transport

cobalt ion transport

zinc ion transport

cellular zinc ion homeostasis

zinc ion binding

cation transmembrane transporter activity

response to zinc ion

regulation of proton transport

membrane

apical plasma membrane

secretory granule

 
238088_at -0.400 3.827 -3.084 7.460e-03 0.376 -2.307 LOC100129194 hypothetical LOC100129194 3   BF511954 3p22.3        
228076_s_at NOL6 nucleolar protein family 6 (RNA-associated) 9 -33451350 BE780892 9p13.3 Hs.493709 10

condensed nuclear chromosome

RNA binding

nucleus

nucleolus

small nucleolar ribonucleoprotein complex

 
239126_at C19orf23 chromosome 19 open reading frame 23 19 -1218470 AA012950 19p13.3 Hs.438829 2    
218107_at 0.571 7.763 3.744 1.911e-03 0.273 -1.149 WDR26 WD repeat domain 26 1 -222639467 NM_025160 1q42.11-q42.12 Hs.497873 8

cytoplasm

 
224053_s_at SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 5 139719970 AF336237 5q31 Hs.550313 3

transporter activity

inorganic anion exchanger activity

anion transport

anion transmembrane transporter activity

antiporter activity

membrane

integral to membrane

apical part of cell

 
230789_at 0.464 4.521 2.234 4.087e-02 0.570 -3.738 ZNF280B zinc finger protein 280B 22 -21168771 AI015954 22q11.22 Hs.43834 6

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
204000_at GNB5 guanine nucleotide binding protein (G protein), beta 5 15 -50200414, -50200414 NM_016194 15q21.2 Hs.155090 26

GTPase activity

signal transducer activity

protein binding

nucleus

heterotrimeric G-protein complex

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

Chemokine signaling pathway

220816_at LPAR3 lysophosphatidic acid receptor 3 1 -85051673 NM_012152 1p22.3 Hs.674915 19

activation of MAPK activity

lysosphingolipid and lysophosphatidic acid receptor activity

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein signaling, coupled to cyclic nucleotide second messenger

elevation of cytosolic calcium ion concentration

synaptic transmission

lipid binding

bleb formation

positive regulation of MAPKKK cascade

Neuroactive ligand-receptor interaction

219050_s_at ZNHIT2 zinc finger, HIT type 2 11 -64640450 NM_014205 11q13 Hs.121025 7

zinc ion binding

metal ion binding

 
213547_at CAND2 cullin-associated and neddylation-dissociated 2 (putative) 3 12813170 AB014567 3p25.2 Hs.343664 7

intracellular

nucleus

transcription activator activity

TATA-binding protein binding

modification-dependent protein catabolic process

regulation of transcription

 
236262_at MMRN2 multimerin 2 10 -88685279 AA025351 10q23.2 Hs.524479 Hs.719260 7

extracellular region

basement membrane

extracellular space

 
226792_s_at KIFC2 kinesin family member C2 8 145662545 BF515031 8q24.3 Hs.528713 7

nucleotide binding

microtubule motor activity

protein binding

ATP binding

microtubule

microtubule-based movement

 
230908_at TACR1 tachykinin receptor 1 2 -75131671, -75127097 AA461490 2p12 Hs.633301 86

receptor activity

G-protein coupled receptor activity

tachykinin receptor activity

protein binding

plasma membrane

integral to plasma membrane

inflammatory response

signal transduction

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

tachykinin receptor signaling pathway

mechanosensory behavior

detection of abiotic stimulus

Calcium signaling pathway

Neuroactive ligand-receptor interaction

235198_at OSTM1 osteopetrosis associated transmembrane protein 1 6 -108469305 AV713913 6q21 Hs.226780 Hs.706947 Hs.719130 16

protein binding

cytosol

membrane

integral to membrane

osteoclast differentiation

 
203395_s_at HES1 hairy and enhancer of split 1, (Drosophila) 3 195336627 NM_005524 3q28-q29 Hs.250666 44

in utero embryonic development

liver development

DNA binding

nucleus

cytoplasm

regulation of transcription, DNA-dependent

cell adhesion

positive regulation of cell proliferation

positive regulation of specific transcription from RNA polymerase II promoter

negative regulation of specific transcription from RNA polymerase II promoter

transcription repressor activity

midbrain-hindbrain boundary morphogenesis

oculomotor nerve development

trochlear nerve development

hindbrain morphogenesis

neural tube development

pituitary gland development

lung development

midbrain development

auditory receptor cell fate determination

cell fate commitment

negative regulation of auditory receptor cell differentiation

negative regulation of neuron differentiation

cell maturation

cell morphogenesis involved in neuron differentiation

regulation of neurogenesis

regulation of timing of neuron differentiation

Notch signaling pathway

Maturity onset diabetes of the young

224677_x_at 0.272 8.682 2.593 2.020e-02 0.493 -3.151 C11orf31 chromosome 11 open reading frame 31 11 57265297 AV729234 11q12.1 Hs.655373 Hs.719147 6

selenium binding

cell redox homeostasis

 
200977_s_at 0.426 9.292 2.536 2.264e-02 0.501 -3.246 TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 7 27746262 AF090891 7p15 Hs.34576 21

intracellular

apoptosis

anti-apoptosis

zinc ion binding

identical protein binding

 
222234_s_at 0.594 5.614 3.017 8.565e-03 0.390 -2.425 DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 16 -88598779, -88598779 AK022644 16q24.3 Hs.301394 5

protein binding

cytoplasm

 
209406_at BAG2 BCL2-associated athanogene 2 6 57145062 AF095192 6p12.1-p11.2 Hs.719303 16

protein binding

protein folding

apoptosis

protein metabolic process

 
235779_at LOC284408 hypothetical protein LOC284408 19   AW467077 19q13.13 Hs.570010 1    
212310_at MIA3 melanoma inhibitory activity family, member 3 1 220858066 D87742 1q41 Hs.118474 13

positive regulation of leukocyte migration

protein binding

endoplasmic reticulum

endoplasmic reticulum membrane

exocytosis

negative regulation of cell adhesion

protein transport

membrane

integral to membrane

negative regulation of cell migration

wound healing

 
242492_at CLNS1A chloride channel, nucleotide-sensitive, 1A 11 -77004844 AA412065 11q13.5-q14 Hs.430733 Hs.598033 24

spliceosomal snRNP biogenesis

nucleus

cytoplasm

cytosol

cytoskeleton

plasma membrane

transport

chloride transport

cell volume homeostasis

blood circulation

 
236008_at LOC100128909 similar to hCG1817494 9   BF510209 9q22.2-q22.31 Hs.535950      
204067_at -0.255 7.561 -2.240 4.040e-02 0.569 -3.729 SUOX sulfite oxidase 12 54677309 AA129776 12q13.2 Hs.558403 23

mitochondrion

mitochondrial intermembrane space

cytosol

response to nutrient

sulfite oxidase activity

electron carrier activity

oxidoreductase activity

heme binding

molybdenum ion binding

molybdopterin cofactor binding

metal ion binding

oxidation reduction

Sulfur metabolism

227718_at PURB purine-rich element binding protein B 7 -44882416 BF337790 7p13 Hs.349150 Hs.596321 13

translation repressor activity, nucleic acid binding

double-stranded DNA binding

single-stranded DNA binding

transcription factor activity

mRNA binding

nucleus

DNA replication factor A complex

transcription factor binding

specific transcriptional repressor activity

purine-rich negative regulatory element binding

regulation of transcription

regulation of myeloid cell differentiation

negative regulation of transcription, DNA-dependent

SMAD binding

 
211866_x_at -0.272 5.244 -2.418 2.860e-02 0.532 -3.442 HFE hemochromatosis 6 26195487 AF079409 6p21.3 Hs.233325 592

antigen processing and presentation of peptide antigen via MHC class I

iron ion binding

protein binding

cytoplasm

early endosome

plasma membrane

integral to plasma membrane

protein complex assembly

ion transport

iron ion transport

cellular iron ion homeostasis

receptor-mediated endocytosis

immune response

antigen processing and presentation

cytoplasmic vesicle

MHC class I protein complex

apical part of cell

basal part of cell

perinuclear region of cytoplasm

recycling endosome

 
201704_at 0.234 7.271 2.322 3.451e-02 0.553 -3.598 ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative function) 20 25124338 NM_001247 20p11.2-p11.22 Hs.500375 15

magnesium ion binding

calcium ion binding

extracellular region

Golgi apparatus

membrane

integral to membrane

hydrolase activity

nucleoside-diphosphatase activity

Purine metabolism

Pyrimidine metabolism

204168_at MGST2 microsomal glutathione S-transferase 2 4 140806371 NM_002413 4q28.3 Hs.81874 11

glutathione transferase activity

membrane fraction

endoplasmic reticulum

microsome

signal transduction

cell-cell signaling

enzyme activator activity

membrane

integral to membrane

transferase activity

leukotriene biosynthetic process

Glutathione metabolism

Metabolism of xenobiotics by cytochrome P450

Drug metabolism - cytochrome P450

228764_s_at MDP1 magnesium-dependent phosphatase 1 14 -23752997 AI813313 14q12 Hs.220963 5

magnesium ion binding

protein tyrosine phosphatase activity

hydrolase activity

 
241937_s_at 0.521 4.444 2.472 2.569e-02 0.517 -3.352 WDR4 WD repeat domain 4 21 -43142404, -43136272 AA577678 21q22.3 Hs.248815 10

protein binding

nucleus

nucleoplasm

cytoplasm

tRNA modification

tRNA (guanine-N7-)-methyltransferase activity

 
206245_s_at 0.720 6.814 2.742 1.498e-02 0.453 -2.898 IVNS1ABP influenza virus NS1A binding protein 1 -183532144 NM_006469 1q25.1-q31.1 Hs.497183 9

protein binding

nucleus

nucleoplasm

transcription factor complex

spliceosomal complex

cytoplasm

cytoskeleton

transcription from RNA polymerase III promoter

RNA splicing

response to virus

interspecies interaction between organisms

 
224090_s_at TNFRSF19 tumor necrosis factor receptor superfamily, member 19 13 23042722, 23051638 AB040434 13q12.11-q12.3 Hs.149168 14

receptor activity

tumor necrosis factor receptor activity

protein binding

mitochondrion

apoptosis

induction of apoptosis

JNK cascade

membrane

integral to membrane

Cytokine-cytokine receptor interaction

218029_at FAM65A family with sequence similarity 65, member A 16 66120254 NM_024519 16q22.1 Hs.152717 5

binding

 
213578_at BMPR1A bone morphogenetic protein receptor, type IA 10 88506375 AI678679 10q22.3 Hs.524477 70

nucleotide binding

magnesium ion binding

mesoderm formation

Mullerian duct regression

positive regulation of mesenchymal cell proliferation

protein serine/threonine kinase activity

receptor activity

transforming growth factor beta receptor activity

ATP binding

plasma membrane

plasma membrane

caveola

protein amino acid phosphorylation

immune response

transforming growth factor beta receptor signaling pathway

pattern specification process

ectoderm development

heart development

dorsal/ventral axis specification

anterior/posterior pattern formation

positive regulation of pathway-restricted SMAD protein phosphorylation

integral to membrane

transferase activity

stem cell maintenance

manganese ion binding

cell differentiation

lung development

positive regulation of bone mineralization

BMP signaling pathway

BMP signaling pathway

hindlimb morphogenesis

odontogenesis of dentine-containing tooth

protein homodimerization activity

positive regulation of osteoblast differentiation

SMAD binding

mesendoderm development

embryonic morphogenesis

positive regulation of epithelial cell proliferation

negative regulation of neurogenesis

cartilage development

palate development

positive regulation of SMAD protein nuclear translocation

Cytokine-cytokine receptor interaction

TGF-beta signaling pathway

200096_s_at 0.264 9.746 2.936 1.010e-02 0.415 -2.564 ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 5 172343368 AI862255 5q35.1 Hs.484188 18

transporter activity

membrane fraction

ion transport

vacuolar acidification

ATP synthesis coupled proton transport

ATP hydrolysis coupled proton transport

proton transport

membrane

integral to membrane

cell growth

hydrolase activity

proton-transporting V-type ATPase, V0 domain

ATPase activity, coupled to transmembrane movement of ions

proton-transporting ATPase activity, rotational mechanism

Oxidative phosphorylation

Metabolic pathways

Vibrio cholerae infection

Epithelial cell signaling in Helicobacter pylori infection

210295_at -0.186 4.509 -2.381 3.076e-02 0.542 -3.502 MAGEA10 melanoma antigen family A, 10 X -151053563 BC004105 Xq28 Hs.18048 6    
213742_at SFRS11 splicing factor, arginine/serine-rich 11 1 70443952 AW241752 1p31 Hs.479693 13

nucleotide binding

nuclear mRNA splicing, via spliceosome

RNA binding

protein binding

nucleus

nucleolus

RNA splicing

 
208331_at -0.341 2.663 -3.286 4.919e-03 0.341 -1.953 BPY2 basic charge, Y-linked, 2 Y -25586437, 23539797, 25173538 NM_004678 Yq11 Hs.664724 7    
218847_at -0.392 5.262 -2.922 1.040e-02 0.418 -2.590 IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3 -186844220 NM_006548 3q27.2 Hs.35354 55

nucleotide binding

RNA binding

protein binding

nucleus

cytoplasm

biological_process

anatomical structure morphogenesis

negative regulation of translation

regulation of cytokine biosynthetic process

cytoskeletal part

translation regulator activity

mRNA 5'-UTR binding

 
210960_at ADRA1D adrenergic, alpha-1D-, receptor 20 -4149277 M76446 20p13 Hs.557 30

negative regulation of the force of heart contraction during baroreceptor response to increased systemic arterial blood pressure

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

receptor activity

G-protein coupled receptor activity

adrenoceptor activity

alpha1-adrenergic receptor activity

plasma membrane

integral to plasma membrane

DNA metabolic process

signal transduction

G-protein coupled receptor protein signaling pathway

G-protein signaling, coupled to cAMP nucleotide second messenger

cell-cell signaling

multicellular organismal development

positive regulation of cell proliferation

Calcium signaling pathway

Neuroactive ligand-receptor interaction

Vascular smooth muscle contraction

211760_s_at -0.497 4.136 -3.072 7.638e-03 0.378 -2.327 VAMP4 vesicle-associated membrane protein 4 1 -169938782 BC005974 1q24-q25 Hs.6651 15

Golgi membrane

lysosome

endosome

Golgi apparatus

membrane

integral to membrane

vesicle-mediated transport

SNARE interactions in vesicular transport

226640_at DAGLB diacylglycerol lipase, beta 7 -6415272 AA015606 7p22.1 Hs.487498 9

triacylglycerol lipase activity

calcium ion binding

plasma membrane

integral to membrane

lipid catabolic process

hydrolase activity

 
216718_at C1orf46 chromosome 1 open reading frame 46 1   AF005082 1q21.3 Hs.516420 1    
1567358_at NAV2 neuron navigator 2 11 19328846, 19691456, 20001211 AJ488204 11p15.1 Hs.502116 Hs.551898 Hs.639427 Hs.639428 18

nucleotide binding

helicase activity

ATP binding

nucleus

nucleolus

cytoplasm

hydrolase activity

 
210767_at NF2 neurofibromin 2 (merlin) 22 28329544, 28329544 BC003112 22q12.2 Hs.187898 131

mesoderm formation

ruffle

negative regulation of cell-matrix adhesion

nucleus

nucleolus

cytoplasm

early endosome

cytoskeleton

plasma membrane

adherens junction

negative regulation of protein kinase activity

ectoderm development

cytoskeletal protein binding

negative regulation of DNA replication

negative regulation of cell proliferation

negative regulation of cell proliferation

Schwann cell proliferation

extrinsic to membrane

negative regulation of cell-cell adhesion

lamellipodium

actin cytoskeleton organization

filopodium

negative regulation of cell migration

cleavage furrow

odontogenesis of dentine-containing tooth

negative regulation of tyrosine phosphorylation of Stat3 protein

negative regulation of tyrosine phosphorylation of Stat5 protein

negative regulation of MAPKKK cascade

cell-cell junction organization

negative regulation of JAK-STAT cascade

perinuclear region of cytoplasm

positive regulation of stress fiber formation

 
226018_at 0.535 7.080 2.262 3.873e-02 0.567 -3.694 C7orf41 chromosome 7 open reading frame 41 7 30141076 W73230 7p14.3 Hs.200100 4    
212615_at CHD9 chromodomain helicase DNA binding protein 9 16 51646445 AI742305 16q12.2 Hs.59159 Hs.622347 10

nucleotide binding

chromatin

DNA binding

chromatin binding

helicase activity

protein binding

ATP binding

nucleus

cytoplasm

chromatin assembly or disassembly

chromatin modification

hydrolase activity

regulation of transcription

 
240862_at RASGRP4 RAS guanyl releasing protein 4 19 -43591537 AA923524 19q13.1 Hs.130434 7

Ras guanyl-nucleotide exchange factor activity

Ras guanyl-nucleotide exchange factor activity

calcium ion binding

intracellular

membrane fraction

membrane fraction

soluble fraction

soluble fraction

cytoplasm

plasma membrane

transmembrane receptor protein tyrosine kinase signaling pathway

activation of phospholipase C activity

zinc ion binding

regulation of G-protein coupled receptor protein signaling pathway

cell proliferation

cell proliferation

response to extracellular stimulus

response to extracellular stimulus

cell growth

cell growth

diacylglycerol binding

myeloid cell differentiation

GTP-dependent protein binding

positive regulation of Ras protein signal transduction

positive regulation of Ras protein signal transduction

regulation of small GTPase mediated signal transduction

MAPK signaling pathway

219879_s_at C17orf53 chromosome 17 open reading frame 53 17 39574851 NM_024032 17q21.31 Hs.437059 3    
225797_at MRPL54 mitochondrial ribosomal protein L54 19 3713664 AV707568 19p13.3 Hs.356578 5

mitochondrion

ribosome

 
1555781_at PQLC2 PQ loop repeat containing 2 1 19511326 BC015324 1p36.13 Hs.647620 5

membrane

integral to membrane

 
202341_s_at 0.333 5.699 2.863 1.172e-02 0.426 -2.691 TRIM2 tripartite motif-containing 2 4 154293719, 154345047 AA149745 4q31.3 Hs.435711 6

protein binding

intracellular

cytoplasm

biological_process

zinc ion binding

metal ion binding

 
223286_at C17orf81 chromosome 17 open reading frame 81 17 7096095, 7096274 BC002762 17p13.1 Hs.417029 8

protein binding

cytoplasm

regulation of transcription

 
238076_at GATAD2B GATA zinc finger domain containing 2B 1 -152043826 AI818098 1q21.3 Hs.4779 Hs.596854 14

transcription factor activity

protein binding

nucleus

nucleolus

regulation of transcription, DNA-dependent

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
218196_at OSTM1 osteopetrosis associated transmembrane protein 1 6 -108469305 NM_014028 6q21 Hs.226780 Hs.706947 Hs.719130 16

protein binding

cytosol

membrane

integral to membrane

osteoclast differentiation

 
209103_s_at UFD1L ubiquitin fusion degradation 1 like (yeast) 22 -17817463 BC001049 22q11.21 Hs.474213 22

skeletal system development

ubiquitin-specific protease activity

protein binding

nucleus

cytoplasm

cytosol

ubiquitin-dependent protein catabolic process

 
221045_s_at -0.797 7.315 -2.459 2.637e-02 0.521 -3.374 PER3 period homolog 3 (Drosophila) 1 7767349 NM_016831 1p36.23 Hs.162200 35

signal transducer activity

nucleus

cytoplasm

regulation of transcription, DNA-dependent

signal transduction

rhythmic process

Circadian rhythm - mammal

224736_at 0.334 7.832 2.129 4.994e-02 0.591 -3.903 CCAR1 cell division cycle and apoptosis regulator 1 10 70150976 BE617899 10q21.3 Hs.49853 18

nuclear mRNA splicing, via spliceosome

nucleic acid binding

nucleus

cytoplasm

Golgi apparatus

apoptosis

cell cycle

perinuclear region of cytoplasm

 
229266_at 0.470 3.200 3.256 5.241e-03 0.348 -2.007 LOC284033 hypothetical LOC284033 17   AI138603 17p12 Hs.592124 2    
230002_at 0.465 5.799 2.902 1.083e-02 0.421 -2.624 CLCC1 chloride channel CLIC-like 1 1 -109273652 AA406603 1p13.3 Hs.658489 6

nucleus

endoplasmic reticulum

Golgi apparatus

membrane

integral to membrane

 
210805_x_at RUNX1 runt-related transcription factor 1 21 -35115443, -35081967, -35081967 U19601 21q22.3 Hs.149261 Hs.612648 256

transcription factor activity

protein binding

ATP binding

nucleus

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

transcription activator activity

positive regulation of granulocyte differentiation

chloride ion binding

positive regulation of angiogenesis

positive regulation of transcription from RNA polymerase II promoter

Pathways in cancer

Chronic myeloid leukemia

Acute myeloid leukemia

236223_s_at RIT1 Ras-like without CAAX 1 1 -154134224 AL037450 1q22 Hs.491234 17

nucleotide binding

calmodulin binding

GTP binding

intracellular

plasma membrane

signal transduction

small GTPase mediated signal transduction

small GTPase mediated signal transduction

 
239136_at hCG_1818231 hCG1818231 10   AI871120 10q22.1   1    
222437_s_at 0.297 9.163 2.270 3.818e-02 0.565 -3.682 VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae) 2 -86584063 BC004419 2p24.3-p24.1 Hs.591582 25

protein binding

cytoplasm

endosome

cytosol

cell cycle

protein transport

membrane

late endosome membrane

cell division

Endocytosis

208826_x_at 0.308 10.976 3.204 5.826e-03 0.357 -2.097 HINT1 histidine triad nucleotide binding protein 1 5 -130522773, -130522773 U27143 5q31.2 Hs.483305 26

protein kinase C binding

nucleus

cytoplasm

cytoskeleton

signal transduction

hydrolase activity

 
212245_at MCFD2 multiple coagulation factor deficiency 2 2 -46982518 AL567779 2p21 Hs.293689 19

calcium ion binding

extracellular region

endoplasmic reticulum

ER-Golgi intermediate compartment

Golgi apparatus

protein transport

vesicle-mediated transport

carboxylic acid metabolic process

 
217835_x_at C20orf24 chromosome 20 open reading frame 24 20 34667580, 34667605 NM_018840 20q11.23 Hs.584985 7

molecular_function

protein binding

cellular_component

biological_process

 
219804_at SYNPO2L synaptopodin 2-like 10 -75074649, -75074649 NM_024875 10q22.2 Hs.645273 4

actin binding

protein binding

cytoplasm

cytoskeleton

 
226267_at 0.723 6.423 4.162 8.111e-04 0.214 -0.424 JDP2 Jun dimerization protein 2 14 74964261, 74964672, 74964812, 74968589 AA716425 14q24.3 Hs.196482 15

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

transcription repressor activity

sequence-specific DNA binding

protein dimerization activity

 
202978_s_at 0.482 5.295 3.052 7.963e-03 0.384 -2.363 CREBZF CREB/ATF bZIP transcription factor 11 -85046257 AW204564 11q14 Hs.535319 Hs.595940 Hs.714910 12

transcription factor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

response to virus

negative regulation of transcription

specific transcriptional repressor activity

sequence-specific DNA binding

negative regulation of gene expression, epigenetic

regulation of transcription factor activity

 
209842_at SOX10 SRY (sex determining region Y)-box 10 22 -36698264 AI367319 22q13.1 Hs.376984 46

in utero embryonic development

DNA binding

chromatin binding

RNA polymerase II transcription factor activity, enhancer binding

transcription coactivator activity

nucleus

cytoplasm

peripheral nervous system development

cell differentiation

melanocyte differentiation

identical protein binding

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

cell maturation

enteric nervous system development

gut morphogenesis

developmental growth

oligodendrocyte differentiation

 
204829_s_at FOLR2 folate receptor 2 (fetal) 11 71605466 NM_000803 11q13.3-q13.5 Hs.433159 24

receptor activity

folic acid binding

extracellular region

membrane fraction

plasma membrane

folic acid transport

anchored to membrane

 
211075_s_at 0.351 7.112 2.172 4.608e-02 0.582 -3.837 CD47 CD47 molecule 3 -109244630 Z25521 3q13.1-q13.2 Hs.446414 68

protein binding

plasma membrane

plasma membrane

integral to plasma membrane

cell adhesion

integrin-mediated signaling pathway

positive regulation of cell proliferation

positive regulation of cell-cell adhesion

positive regulation of T cell activation

thrombospondin receptor activity

ECM-receptor interaction

203528_at SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 9 -91181971, -91165525 NM_006378 9q22.2 Hs.494406 29

receptor activity

receptor binding

anti-apoptosis

immune response

cell adhesion

multicellular organismal development

nervous system development

membrane

integral to membrane

cell differentiation

positive regulation of axonogenesis

Axon guidance

220391_at ZBTB3 zinc finger and BTB domain containing 3 11 -62275012 NM_024784 11q12.3 Hs.147554 5

DNA binding

protein binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
204219_s_at 0.273 10.248 2.446 2.707e-02 0.525 -3.396 PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 14 89792646 NM_002802 14q32.11 Hs.356654 51

nucleotide binding

proteasome complex

protein binding

ATP binding

nucleus

nucleolus

cytoplasm

cytosol

hydrolase activity

ATPase activity

protein catabolic process

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

209311_at 0.279 6.931 2.305 3.569e-02 0.556 -3.626 BCL2L2 BCL2-like 2 14 22845851 D87461 14q11.2-q12 Hs.410026 31

protein binding

mitochondrion

cytosol

anti-apoptosis

spermatogenesis

membrane

mitochondrial membrane

regulation of apoptosis

Sertoli cell proliferation

 
238805_at 0.756 5.372 4.038 1.045e-03 0.225 -0.637 C11orf52 chromosome 11 open reading frame 52 11 111294810 AA991551 11q23.1 Hs.97013 3    
234257_at TNS3 tensin 3 7 -47281276 AL137468 7p12.3 Hs.520814 12

protein binding

nucleus

nucleolus

cytoplasm

plasma membrane

focal adhesion

positive regulation of cell proliferation

cell migration

cell junction

lung alveolus development

 
1556420_s_at YPEL2 yippee-like 2 (Drosophila) 17 54763834 AK097253 17q22 Hs.463613 5

nucleus

nucleolus

 
206976_s_at HSPH1 heat shock 105kDa/110kDa protein 1 13 -30608762 NM_006644 13q12.3 Hs.36927 25

nucleotide binding

ATP binding

cytoplasm

response to unfolded protein

 
206974_at CXCR6 chemokine (C-X-C motif) receptor 6 3 45959976 NM_006564 3p21 Hs.34526 37

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

coreceptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity

viral genome replication

Cytokine-cytokine receptor interaction

Chemokine signaling pathway

208799_at 0.217 10.104 2.284 3.717e-02 0.562 -3.660 PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 14 -22564900, -22564900 BC004146 14q11.2 Hs.422990 53

threonine-type endopeptidase activity

protein binding

nucleus

cytoplasm

cytosol

proteasome core complex

peptidase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

proteolysis involved in cellular protein catabolic process

Proteasome

202748_at GBP2 guanylate binding protein 2, interferon-inducible 1 -89345897 NM_004120 1p22.2 Hs.386567 13

nucleotide binding

GTPase activity

GTP binding

plasma membrane

immune response

 
1565337_at DNAH6 dynein, axonemal, heavy chain 6 2 84597089 AJ132086 2p11.2 Hs.249972 7

nucleotide binding

microtubule motor activity

ATP binding

microtubule

microtubule-based movement

ATPase activity

dynein complex

 
213999_at YIPF4 Yip1 domain family, member 4 2 32356461 BE999993 2p22.3 Hs.468099 11

endoplasmic reticulum

membrane

integral to membrane

 
231571_at LOC285827 hypothetical protein LOC285827 6   AA939337 6p21.33 Hs.99161 1    
203735_x_at -0.361 8.597 -2.196 4.401e-02 0.579 -3.799 PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 12 27568311, 27568311 N35896 12p11.23-p11.22 Hs.172445 11

protein binding

plasma membrane

cell adhesion

 
211462_s_at 0.213 4.373 2.228 4.141e-02 0.572 -3.749 TBL1Y transducin (beta)-like 1Y-linked Y 6838726 AF332222 Yp11.2 Hs.664560 5

chromatin binding

protein binding

nucleus

transcription factor complex

regulation of transcription from RNA polymerase II promoter

modification-dependent protein catabolic process

regulation of transcription

Wnt signaling pathway

227798_at 0.396 7.699 2.185 4.493e-02 0.581 -3.816 SMAD1 SMAD family member 1 4 146622400, 146623406 AU146891 4q31 Hs.604588 118

MAPKKK cascade

mesodermal cell fate commitment

osteoblast fate commitment

transcription factor activity

RNA polymerase II transcription factor activity

receptor signaling protein activity

intracellular

nucleus

nucleoplasm

transcription factor complex

cytoplasm

cytosol

inflammatory response

signal transduction

transforming growth factor beta receptor signaling pathway

SMAD protein complex assembly

gamete generation

negative regulation of cell proliferation

embryonic pattern specification

positive regulation of gene expression

integral to membrane

transcription activator activity

BMP signaling pathway

BMP signaling pathway

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

midbrain development

hindbrain development

primary microRNA processing

homeostatic process

identical protein binding

positive regulation of osteoblast differentiation

positive regulation of transcription from RNA polymerase II promoter

co-SMAD binding

TGF-beta signaling pathway

236939_at PTPLAD2 protein tyrosine phosphatase-like A domain containing 2 9 -20996364 AA687316 9p21.3 Hs.716678 1

membrane

integral to membrane

 
207215_at GSTTP1 glutathione S-transferase theta pseudogene 1 22 -22670594 NM_015371 22q12 Hs.652490 1    
214395_x_at EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 8 -144733040, -144733040 AI335509 8q24.3 Hs.333388 Hs.686554 42

translation elongation factor activity

signal transducer activity

protein binding

cytosol

eukaryotic translation elongation factor 1 complex

translational elongation

translational elongation

positive regulation of I-kappaB kinase/NF-kappaB cascade

 
207826_s_at ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1 -23756995 NM_002167 1p36.13-p36.12 Hs.76884 41

negative regulation of transcription from RNA polymerase II promoter

transcription corepressor activity

nucleus

nucleus

regulation of DNA replication

multicellular organismal development

heart development

transcription factor binding

response to wounding

negative regulation of transcription

protein domain specific binding

neuron differentiation

epithelial cell differentiation

positive regulation of apoptosis

negative regulation of transcription factor activity

TGF-beta signaling pathway

218171_at VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 18 -59207404 AF195514 18q21.32-q21.33 Hs.126550 27

nucleotide binding

ATP binding

nucleus

cytoplasm

lysosome

early endosome

late endosome

vacuolar membrane

cytosol

ATP catabolic process

potassium ion transport

endosome organization

cell cycle

protein C-terminus binding

endosome membrane

protein transport

membrane

endosome transport

intracellular cholesterol transport

endosome to lysosome transport via multivesicular body sorting pathway

response to lipid

ATPase activity, coupled

cell division

Endocytosis

237256_at -0.246 4.427 -2.446 2.706e-02 0.525 -3.396 FBXL12 F-box and leucine-rich repeat protein 12 19 -9781942 AI479104 19p13.2 Hs.12439 7

ubiquitin ligase complex

cytoplasm

ubiquitin-dependent protein catabolic process

 
222212_s_at LASS2 LAG1 homolog, ceramide synthase 2 1 -149204272 AK001105 1q21.3 Hs.713103 10

transcription factor activity

protein binding

nucleus

endoplasmic reticulum

regulation of transcription, DNA-dependent

lipid biosynthetic process

membrane

integral to membrane

sequence-specific DNA binding

 
1562005_at RIN3 Ras and Rab interactor 3 14 92049877 BC034153 14q32.12 Hs.326822 8

GTPase activator activity

protein binding

cellular_component

cytoplasm

early endosome

endocytosis

signal transduction

Ras GTPase binding

cytoplasmic vesicle

 
239999_at C21orf34 chromosome 21 open reading frame 34 21 16364712, 16488569 N66393 21q21.1 Hs.719301 5    
213295_at 0.654 7.041 2.596 2.008e-02 0.491 -3.145 CYLD cylindromatosis (turban tumor syndrome) 16 49333461, 49333529 AA555096 16q12.1 Hs.578973 54

structural constituent of ribosome

ubiquitin thiolesterase activity

intracellular

cytoplasm

ribosome

cytoskeleton

translation

ubiquitin-dependent protein catabolic process

cell cycle

peptidase activity

cysteine-type peptidase activity

perinuclear region of cytoplasm

RIG-I-like receptor signaling pathway

215606_s_at ERC1 ELKS/RAB6-interacting/CAST family member 1 12 970664 AB029004 12p13.3 Hs.655744 Hs.658200 19

protein binding

cytoplasm

Golgi apparatus

regulation of transcription, DNA-dependent

I-kappaB phosphorylation

multicellular organismal development

IkappaB kinase complex

protein transport

Rab GTPase binding

retrograde transport, endosome to Golgi

presynaptic membrane

leucine zipper domain binding

positive regulation of anti-apoptosis

positive regulation of NF-kappaB transcription factor activity

 
1559244_at -0.311 3.914 -3.132 6.753e-03 0.368 -2.222 FMN2 formin 2 1 238321807 AF218941 1q43 Hs.24889 7

molecular_function

actin binding

cellular_component

meiotic metaphase I

multicellular organismal development

cellular component organization

meiotic chromosome movement towards spindle pole

actin cytoskeleton organization

polar body extrusion after meiotic divisions

oogenesis

establishment of meiotic spindle localization

Dorso-ventral axis formation

220918_at 0.936 5.060 2.860 1.180e-02 0.426 -2.697 C21orf96 chromosome 21 open reading frame 96 21 -35332104 NM_025143 21q22.12 Hs.672131 4

cytosol

 
203568_s_at 0.601 6.390 3.584 2.663e-03 0.290 -1.430 TRIM38 tripartite motif-containing 38 6 26071049 NM_006355 6p21.3 Hs.584851 7

signal transducer activity

protein binding

cellular_component

intracellular

zinc ion binding

positive regulation of I-kappaB kinase/NF-kappaB cascade

metal ion binding

 
202651_at LPGAT1 lysophosphatidylglycerol acyltransferase 1 1 -209983422 NM_014873 1q32 Hs.497674 6

molecular_function

cytoplasm

endoplasmic reticulum

metabolic process

acyltransferase activity

phospholipid biosynthetic process

membrane

integral to membrane

transferase activity

 
1554168_a_at SH3KBP1 SH3-domain kinase binding protein 1 X -19462003, -19462003 AF542051 Xp22.1-p21.3 Hs.719268 58

molecular_function

protein binding

nucleus

nucleolus

cytoplasm

cytosol

cytoskeleton

plasma membrane

focal adhesion

endocytosis

apoptosis

cell-cell signaling

SH3 domain binding

synaptosome

cell junction

cytoplasmic vesicle

synapse

Endocytosis

203122_at TTC15 tetratricopeptide repeat domain 15 2 3362452 NM_016030 2p25.3 Hs.252713 4

binding

 
232173_at CLEC2L C-type lectin domain family 2, member L 7 138859213 W60866 7q34 Hs.57806 3

binding

sugar binding

membrane

integral to membrane

 
202059_s_at KPNA1 karyopherin alpha 1 (importin alpha 5) 3 -123623437 NM_002264 3q21 Hs.161008 92

regulation of DNA recombination

protein binding

nucleus

nuclear pore

nucleoplasm

cytoplasm

cytosol

NLS-bearing substrate import into nucleus

intracellular protein transport

nuclear localization sequence binding

protein transporter activity

interspecies interaction between organisms

 
219925_at -0.199 3.493 -2.136 4.935e-02 0.590 -3.893 ZMYM6 zinc finger, MYM-type 6 1 -35224353 NM_007167 1p34.2 Hs.533986 Hs.623978 Hs.675613 8

DNA binding

nucleus

nucleolus

multicellular organismal development

zinc ion binding

metal ion binding

 
209710_at GATA2 GATA binding protein 2 3 -129680954, -129680954, -129680954 AL563460 3q21.3 Hs.367725 60

cell fate determination

embryonic placenta development

transcription factor activity

nucleus

nucleolus

regulation of transcription, DNA-dependent

transcription factor binding

zinc ion binding

positive regulation of specific transcription from RNA polymerase II promoter

pituitary gland development

neuron differentiation

sequence-specific DNA binding

positive regulation of angiogenesis

metal ion binding

cell maturation

positive regulation of phagocytosis

 
205796_at 0.287 3.406 2.178 4.552e-02 0.581 -3.827 TCP11L1 t-complex 11 (mouse)-like 1 11 33017538, 33018136 NM_018393 11p13 Hs.655341 4    
210024_s_at UBE2E3 ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast) 2 181553356, 181553586 AB017644 2q32.1 Hs.470804 20

nucleotide binding

ubiquitin-protein ligase activity

protein binding

ATP binding

nucleus

cytoplasm

ligase activity

modification-dependent protein catabolic process

regulation of growth

post-translational protein modification

regulation of protein metabolic process

Ubiquitin mediated proteolysis

240363_at ANK1 ankyrin 1, erythrocytic 8 -41629901, -41629901, -41629900 AW044553 8p11.1 Hs.654438 Hs.667377 49

structural constituent of cytoskeleton

cytoplasm

plasma membrane

exocytosis

cytoskeleton organization

signal transduction

cytoskeletal adaptor activity

spectrin-associated cytoskeleton

basolateral plasma membrane

sarcoplasmic reticulum

enzyme binding

spectrin binding

M band

maintenance of epithelial cell apical/basal polarity

 
229676_at 0.444 6.728 2.846 1.214e-02 0.426 -2.721 MTPAP mitochondrial poly(A) polymerase 10 -30638735 AA400998 10p11.23 Hs.173946 13

nucleotide binding

RNA binding

polynucleotide adenylyltransferase activity

ATP binding

mitochondrion

transcription

mRNA processing

transferase activity

 
1569351_at -0.194 4.829 -2.199 4.374e-02 0.578 -3.794 SOBP sine oculis binding protein homolog (Drosophila) 6 107918009 BC014859 6q21 Hs.445244 4

zinc ion binding

metal ion binding

 
201079_at SYNGR2 synaptogyrin 2 17 73676265 NM_004710 17q25.3 Hs.464210 Hs.708616 5

integral to plasma membrane

membrane

 
213992_at 0.638 4.831 2.506 2.403e-02 0.509 -3.296 COL4A6 collagen, type IV, alpha 6 X -107285492, -107285492 AI889941 Xq22 Hs.145586 35

extracellular matrix structural constituent

protein binding

extracellular region

collagen

collagen type IV

cell adhesion

extracellular matrix organization

Focal adhesion

ECM-receptor interaction

Pathways in cancer

Small cell lung cancer

210384_at PRMT2 protein arginine methyltransferase 2 21 46879954 U79286 21q22.3 Hs.154163 17

signal transducer activity

nucleus

protein amino acid methylation

signal transduction

methyltransferase activity

transferase activity

identical protein binding

 
225186_at RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 -204014436, -204006783 BF114947 2q33 Hs.471162 13

nucleus

cytoplasm

cytoskeleton

plasma membrane

cell-matrix adhesion

signal transduction

lamellipodium

filopodium

 
217834_s_at SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 6 -86380411, -86380411, -86374221, -86374221, -86374221, -86374221 NM_006372 6q14-q15 Hs.571177 33

nucleotide binding

RNA binding

protein binding

nucleus

nucleoplasm

spliceosomal complex

cytoplasm

endoplasmic reticulum

microsome

mRNA processing

poly(A) RNA binding

RNA splicing

interspecies interaction between organisms

 
220589_s_at ITFG2 integrin alpha FG-GAP repeat containing 2 12 2792123 NM_018463 12p13.33 Hs.446098 Hs.448720 2    
206759_at FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 19 -7659643 NM_002002 19p13.3 Hs.465778 71

receptor activity

integrin binding

binding

sugar binding

extracellular region

plasma membrane

integral to plasma membrane

IgE binding

positive regulation of nitric-oxide synthase activity

positive regulation of killing of cells of another organism

positive regulation of nitric-oxide synthase 2 biosynthetic process

Hematopoietic cell lineage

226938_at 0.326 5.916 2.229 4.128e-02 0.571 -3.746 DCAF4 DDB1 and CUL4 associated factor 4 14 72462792 AA160604 14q24.3 Hs.331491 4    
215255_at IGSF9B immunoglobulin superfamily, member 9B 11 -133290394 AB028953 11q25 Hs.204121 3    
227542_at SOCS6 suppressor of cytokine signaling 6 18 66107116 AU157543 18q22.2 Hs.44439 13

protein binding

cytoplasm

defense response

intracellular signaling cascade

JAK-STAT cascade

negative regulation of signal transduction

modification-dependent protein catabolic process

regulation of growth

 
224827_at 0.403 6.243 2.141 4.885e-02 0.590 -3.885 UBTD2 ubiquitin domain containing 2 5 -171569254 AK022894 5q35.1 Hs.131570 Hs.716824 7

cytoplasm

 
200033_at DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 17 -59924835 NM_004396 17q21 Hs.279806 50

nucleotide binding

RNA binding

RNA helicase activity

protein binding

ATP binding

nucleus

spliceosomal complex

nucleolus

mRNA processing

ATP-dependent helicase activity

RNA splicing

cell growth

hydrolase activity

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

 
1553422_s_at 0.496 9.039 3.643 2.355e-03 0.284 -1.326 A2BP1 ataxin 2-binding protein 1 16 6009132, 6763810, 7322751 NM_145892 16p13.3 Hs.459842 22

nucleotide binding

RNA binding

nucleus

cytoplasm

trans-Golgi network

mRNA processing

protein C-terminus binding

RNA splicing

RNA transport

 
219827_at -0.837 8.156 -2.244 4.015e-02 0.569 -3.723 UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 11 -73391459, -73388975 NM_003356 11q13 Hs.101337 Hs.621879 108

response to superoxide

response to hypoxia

transporter activity

binding

mitochondrion

mitochondrial inner membrane

lipid metabolic process

fatty acid metabolic process

transport

mitochondrial transport

respiratory gaseous exchange

proton transport

membrane

integral to membrane

oxidative phosphorylation uncoupler activity

 
218208_at PQLC1 PQ loop repeat containing 1 18 -75763408 NM_025078 18q23 Hs.288284 3

membrane

integral to membrane

 
213782_s_at MYOZ2 myozenin 2 4 120276386 BF939176 4q26-q27 Hs.381047 16

protein binding

cytoplasm

biological_process

actin cytoskeleton

sarcomere

Z disc

protein phosphatase 2B binding

 
202973_x_at FAM13A family with sequence similarity 13, member A 4 -89866128, -89866128 NM_014883 4q22.1 Hs.97270 7    
202272_s_at FBXO28 F-box protein 28 1 222368413 NM_015176 1q42.11 Hs.64691 Hs.713992 10

modification-dependent protein catabolic process

 
226065_at -0.397 6.761 -2.582 2.065e-02 0.497 -3.169 PRICKLE1 prickle homolog 1 (Drosophila) 12 -41138407, -41138407, -41138407 N98595 12q12 Hs.524348 Hs.639400 14

nucleus

cytoplasm

cytosol

zinc ion binding

membrane

nuclear membrane

metal ion binding

Wnt signaling pathway

1564204_at FAM91A2 family with sequence similarity 91, member A2 1   AK090660 1q21.1 Hs.710717 3    
1559926_at -0.464 5.115 -2.411 2.900e-02 0.534 -3.453 LOC728353 hypothetical protein LOC728353 14   BC031683 14q11.2 Hs.621210      
1558174_at FAM43A family with sequence similarity 43, member A 3 195887910 BM050463 3q29 Hs.708232 5    
218092_s_at AGFG1 ArfGAP with FG repeats 1 2 228045131 NM_004504 2q36.3 Hs.352962 29

DNA binding

RNA binding

protein binding

nucleus

nuclear pore

Golgi apparatus

mRNA export from nucleus

transport

multicellular organismal development

spermatogenesis

ARF GTPase activator activity

zinc ion binding

cell differentiation

cytoplasmic vesicle

regulation of ARF GTPase activity

metal ion binding

 
201459_at 0.470 8.232 2.701 1.626e-02 0.462 -2.968 RUVBL2 RuvB-like 2 (E. coli) 19 54188967 NM_006666 19q13.3 Hs.515846 46

nucleotide binding

damaged DNA binding

ATP-dependent DNA helicase activity

ATP binding

intracellular

nucleus

nucleoplasm

cytoplasm

DNA repair

DNA recombination

protein folding

membrane

nuclear matrix

chromatin modification

hydrolase activity

ATPase activity

NuA4 histone acetyltransferase complex

regulation of growth

identical protein binding

histone H4 acetylation

histone H2A acetylation

regulation of transcription

unfolded protein binding

 
224755_at 0.257 7.152 2.301 3.597e-02 0.557 -3.632 TM9SF3 transmembrane 9 superfamily member 3 10 -98267856 BE621524 10q24.1 Hs.500674 5

binding

membrane

integral to membrane

 
212733_at KIAA0226 KIAA0226 3 -198882710, -198882655 AI798908 3q29 Hs.478868 6    
204696_s_at -0.235 5.147 -2.487 2.495e-02 0.513 -3.328 CDC25A cell division cycle 25 homolog A (S. pombe) 3 -48173671 NM_001789 3p21 Hs.437705 89

regulation of cyclin-dependent protein kinase activity

protein tyrosine phosphatase activity

protein binding

cellular_component

intracellular

nucleoplasm

DNA replication

protein amino acid dephosphorylation

cell cycle

mitosis

cell proliferation

hydrolase activity

cell division

Cell cycle

1553515_at MYEOV2 myeloma overexpressed 2 2 -240718914, -240714652 NM_138336 2q37.3 Hs.293884 2    
222980_at RAB10 RAB10, member RAS oncogene family 2 26110477 AL136650 2p23.3 Hs.467960 Hs.643072 14

nucleotide binding

protein binding

GTP binding

Golgi apparatus

plasma membrane

small GTPase mediated signal transduction

protein transport

 
204919_at PRR4 proline rich 4 (lacrimal) 12 -10889714, -10889714 NM_007244 12p13 Hs.408153 7

extracellular region

extracellular space

visual perception

 
207364_at -0.341 5.050 -2.716 1.579e-02 0.459 -2.943 TEX28 testis expressed 28 X -153152125 NM_001586 Xq28 Hs.672606 7

molecular_function

biological_process

membrane

integral to membrane

 
212375_at EP400 E1A binding protein p400 12 131000460 AL563727 12q24.33 Hs.699245 19

nucleotide binding

DNA binding

helicase activity

ATP binding

nucleus

nucleolus

chromatin modification

hydrolase activity

NuA4 histone acetyltransferase complex

histone H4 acetylation

histone H2A acetylation

 
218730_s_at OGN osteoglycin 9 -94186069 NM_014057 9q22 Hs.109439 24

molecular_function

protein binding

extracellular region

proteinaceous extracellular matrix

endoplasmic reticulum

growth factor activity

biological_process

 
1567214_a_at 0.548 6.760 3.630 2.419e-03 0.284 -1.349 PNN pinin, desmosome associated protein 14 38714137 U59479 14q21.1 Hs.409965 30

DNA binding

structural molecule activity

protein binding

nucleus

spliceosomal complex

nucleolus

cytoplasm

intermediate filament

plasma membrane

mRNA processing

cell adhesion

RNA splicing

nuclear speck

desmosome

regulation of transcription

 
204990_s_at ITGB4 integrin, beta 4 17 71229110, 71232370 NM_000213 17q25 Hs.632226 120

receptor activity

protein binding

cell communication

cell adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

integrin complex

membrane

integral to membrane

Focal adhesion

ECM-receptor interaction

Regulation of actin cytoskeleton

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

204268_at 0.544 4.842 2.401 2.954e-02 0.536 -3.469 S100A2 S100 calcium binding protein A2 1 -151800208 NM_005978 1q21 Hs.516484 45

calcium ion binding

cellular_component

endothelial cell migration

 
243954_at -0.303 3.946 -2.324 3.438e-02 0.553 -3.595 LOC285286 hypothetical protein LOC285286 3   AI149729 3p14.2 Hs.559386 1    
205172_x_at CLTB clathrin, light chain (Lcb) 5 -175752061 NM_007097 4q2-q3 5q35 Hs.484241 17

structural molecule activity

calcium ion binding

protein binding

intracellular protein transport

membrane

vesicle-mediated transport

clathrin coat of trans-Golgi network vesicle

clathrin coat of coated pit

cytoplasmic vesicle

Lysosome

Endocytosis

Huntington's disease

230915_at DHRS7C dehydrogenase/reductase (SDR family) member 7C 17 -9615479 AI741629 17p13.1 Hs.61684 1

binding

extracellular region

oxidoreductase activity

oxidation reduction

 
221829_s_at TNPO1 transportin 1 5 72148173, 72179685 AI307759 5q13.2 Hs.482497 58

protein import into nucleus, docking

protein import into nucleus, translocation

protein binding

nucleus

nuclear pore

cytoplasm

nuclear localization sequence binding

protein transporter activity

interspecies interaction between organisms

 
207468_s_at SFRP5 secreted frizzled-related protein 5 10 -99516497 NM_003015 10q24.1 Hs.279565 14

protein binding

extracellular region

extracellular space

apoptosis

establishment or maintenance of cell polarity

signal transduction

multicellular organismal development

visual perception

anatomical structure morphogenesis

Wnt receptor signaling pathway

cell differentiation

Wnt signaling pathway

216992_s_at GRM8 glutamate receptor, metabotropic 8 7 -125865887, -125865887 AJ236922 7q31.3-q32.1 Hs.449625 22

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

negative regulation of adenylate cyclase activity

visual perception

sensory perception of smell

glutamate receptor activity

negative regulation of cAMP biosynthetic process

response to stimulus

Neuroactive ligand-receptor interaction

40225_at GAK cyclin G associated kinase 4 -833064 D88435 4p16 Hs.369607 19

nucleotide binding

protein serine/threonine kinase activity

ATP binding

cytoplasm

Golgi apparatus

focal adhesion

protein amino acid phosphorylation

cell cycle

transferase activity

cell junction

heat shock protein binding

perinuclear region of cytoplasm

 
210170_at PDLIM3 PDZ and LIM domain 3 4 -186659844 BC001017 4q35 Hs.85862 12

nucleus

nucleolus

cytoplasm

actin filament organization

heart development

cytoskeletal protein binding

zinc ion binding

structural constituent of muscle

actin cytoskeleton

Z disc

metal ion binding

 
219268_at ETNK2 ethanolamine kinase 2 1 -202366812 NM_018208 1q32.1 Hs.497469 8

nucleotide binding

in utero embryonic development

placenta development

choline kinase activity

ethanolamine kinase activity

ATP binding

cellular_component

phosphatidylethanolamine biosynthetic process

biological_process

post-embryonic development

transferase activity

multicellular organism growth

Glycerophospholipid metabolism

Metabolic pathways

209896_s_at 0.835 6.546 2.301 3.595e-02 0.557 -3.632 PTPN11 protein tyrosine phosphatase, non-receptor type 11 12 111340918 AF119855 12q24 Hs.506852 Hs.646231 326

non-membrane spanning protein tyrosine phosphatase activity

non-membrane spanning protein tyrosine phosphatase activity

protein binding

cytoplasm

cytosol

protein amino acid dephosphorylation

signal transduction

hydrolase activity

Jak-STAT signaling pathway

Natural killer cell mediated cytotoxicity

Leukocyte transendothelial migration

Neurotrophin signaling pathway

Adipocytokine signaling pathway

Epithelial cell signaling in Helicobacter pylori infection

Renal cell carcinoma

Chronic myeloid leukemia

242902_at CYMP chymosin pseudogene 1 110824910 AI479358 1p13.3 Hs.532720 4    
222830_at 0.362 3.912 2.384 3.056e-02 0.541 -3.497 GRHL1 grainyhead-like 1 (Drosophila) 2 10009242 BE566136 2p25.1 Hs.418493 10

DNA binding

nucleus

nucleolus

cytoplasm

Golgi apparatus

multicellular organismal development

regulation of transcription

 
219371_s_at KLF2 Kruppel-like factor 2 (lung) 19 16296650 NM_016270 19p13.13-p13.11 Hs.715677 38

transcription factor activity

protein binding

intracellular

nucleus

zinc ion binding

transcription activator activity

positive regulation of transcription

metal ion binding

 
1555741_at -0.270 3.722 -2.495 2.455e-02 0.513 -3.314 MRAP melanocortin 2 receptor accessory protein 21 32585994, 32585994 AF483549 21q22.1 Hs.584940 12

cytoplasm

endoplasmic reticulum

plasma membrane

integral to membrane

perinuclear region of cytoplasm

 
225429_at PPP6C protein phosphatase 6, catalytic subunit 9 -126948672 BF437011 9q33.3 Hs.715605 16

G1/S transition of mitotic cell cycle

protein serine/threonine phosphatase activity

iron ion binding

protein binding

cytoplasm

cytosol

protein amino acid dephosphorylation

cell cycle

hydrolase activity

manganese ion binding

metal ion binding

 
218295_s_at NUP50 nucleoporin 50kDa 22 43938389, 43939215 NM_007172 22q13.31 Hs.715672 15

protein binding

nucleus

nuclear pore

nucleoplasm

protein transport

membrane

intracellular transport

mRNA transport

intracellular protein transmembrane transport

 
212470_at SPAG9 sperm associated antigen 9 17 -46394534 AB011088 17q21.33 Hs.463439 22

acrosomal vesicle

protein binding

cytoplasm

spermatogenesis

integral to membrane

positive regulation of cell migration

perinuclear region of cytoplasm

 
207315_at CD226 CD226 molecule 18 -65681172 NM_006566 18q22.3 Hs.660130 28

cytokine production

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

positive regulation of immunoglobulin mediated immune response

receptor activity

integrin binding

integral to plasma membrane

cell adhesion

signal transduction

cell recognition

cell surface

membrane

protein kinase binding

positive regulation of mast cell activation

membrane raft

cell adhesion molecule binding

positive regulation of Fc receptor mediated stimulatory signaling pathway

Cell adhesion molecules (CAMs)

242499_at U2AF1 U2 small nuclear RNA auxiliary factor 1 21 -43386134 AA448694 21q22.3 Hs.365116 47

nucleotide binding

nuclear mRNA splicing, via spliceosome

nuclear mRNA splicing, via spliceosome

RNA binding

protein binding

nucleus

spliceosomal complex

zinc ion binding

RNA splicing

Cajal body

metal ion binding

RS domain binding

 
209785_s_at PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 19 -53242912 AF065214 19q13.3 Hs.631562 22

phospholipid binding

cytosol

inflammatory response

intracellular signaling cascade

parturition

metabolic process

membrane

lipid catabolic process

hydrolase activity

arachidonic acid metabolic process

glycerophospholipid catabolic process

calcium-independent phospholipase A2 activity

 
219751_at SETD6 SET domain containing 6 16 57106883 NM_024860 16q21 Hs.592060 5    
200880_at 0.536 7.305 2.868 1.161e-02 0.426 -2.683 DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 9 33015208 AL534104 9p13-p12 Hs.445203 Hs.707338 27

protein folding

response to unfolded protein

spermatogenesis

zinc ion binding

membrane

sperm motility

androgen receptor signaling pathway

heat shock protein binding

metal ion binding

low-density lipoprotein receptor binding

unfolded protein binding

 
206854_s_at MAP3K7 mitogen-activated protein kinase kinase kinase 7 6 -91282073, -91282073 NM_003188 6q16.1-q16.3 Hs.719192 114

nucleotide binding

magnesium ion binding

positive regulation of T cell cytokine production

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

protein tyrosine kinase activity

protein binding

ATP binding

cytosol

protein amino acid phosphorylation

signal transduction

transforming growth factor beta receptor signaling pathway

activation of NF-kappaB-inducing kinase activity

transferase activity

positive regulation of interleukin-2 production

T cell receptor signaling pathway

positive regulation of T cell activation

MAPK signaling pathway

Wnt signaling pathway

Adherens junction

Toll-like receptor signaling pathway

RIG-I-like receptor signaling pathway

T cell receptor signaling pathway

203455_s_at SAT1 spermidine/spermine N1-acetyltransferase 1 X 23711195 NM_002970 Xp22.1 Hs.28491 46

diamine N-acetyltransferase activity

protein binding

intracellular

cytoplasm

metabolic process

acyltransferase activity

transferase activity

Arginine and proline metabolism

Metabolic pathways

209799_at 0.619 3.757 3.598 2.587e-03 0.287 -1.406 PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 5 -40795237 AF100763 5p12 Hs.43322 68

nucleotide binding

activation of MAPK activity

magnesium ion binding

response to hypoxia

protein serine/threonine kinase activity

cAMP-dependent protein kinase activity

protein binding

ATP binding

intracellular

glucose metabolic process

fatty acid biosynthetic process

signal transduction

transferase activity

fatty acid oxidation

positive regulation of cholesterol biosynthetic process

positive regulation of anti-apoptosis

negative regulation of glucosylceramide biosynthetic process

Regulation of autophagy

mTOR signaling pathway

Insulin signaling pathway

Adipocytokine signaling pathway

Hypertrophic cardiomyopathy (HCM)

201417_at SOX4 SRY (sex determining region Y)-box 4 6 21701950 AL136179 6p22.3 Hs.643910 35

pro-B cell differentiation

transcription factor activity

protein binding

nucleus

cytoplasm

heart development

positive regulation of cell proliferation

positive regulation of Wnt receptor signaling pathway

T cell differentiation

exocrine pancreas development

positive regulation of apoptosis

negative regulation of apoptosis

positive regulation of transcription, DNA-dependent

protein stabilization

Wnt receptor signaling pathway through beta-catenin

 
214404_x_at SPDEF SAM pointed domain containing ets transcription factor 6 -34613557 AI435670 6p21.3 Hs.485158 21

transcription factor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

sequence-specific DNA binding

 
205976_at FASTKD2 FAST kinase domains 2 2 207338356 NM_014929 2q33.3 Hs.5930 8

protein kinase activity

ATP binding

apoptosis

 
219317_at 0.475 4.457 2.591 2.028e-02 0.494 -3.154 POLI polymerase (DNA directed) iota 18 50049846 NM_007195 18q21.1 Hs.438533 58

magnesium ion binding

damaged DNA binding

DNA-directed DNA polymerase activity

protein binding

intracellular

nucleus

nucleoplasm

DNA replication

DNA repair

response to DNA damage stimulus

transferase activity

nucleotidyltransferase activity

 
1554949_at -0.248 5.454 -2.351 3.259e-02 0.548 -3.551 LOC554174 hypothetical LOC554174 22   BC009388 22q13.31 Hs.660824 1    
225662_at ZAK sterile alpha motif and leucine zipper containing kinase AZK 2 173648810, 173648810 H28667 2q24.2 Hs.444451 24

cell cycle checkpoint

DNA damage checkpoint

nucleotide binding

activation of MAPKK activity

magnesium ion binding

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

protein tyrosine kinase activity

ATP binding

nucleus

cytoplasm

response to stress

cell cycle

cell cycle arrest

protein kinase cascade

activation of JUN kinase activity

cell death

cell proliferation

response to radiation

transferase activity

cell differentiation

identical protein binding

positive regulation of apoptosis

MAPK signaling pathway

Tight junction

227396_at 0.562 5.515 2.478 2.543e-02 0.515 -3.344 PTPRJ protein tyrosine phosphatase, receptor type, J 11 47958685, 47958685 AI631833 11p11.2 Hs.318547 36

transmembrane receptor protein tyrosine phosphatase activity

protein binding

nucleus

plasma membrane

integral to plasma membrane

protein amino acid dephosphorylation

transmembrane receptor protein tyrosine kinase signaling pathway

cell-cell signaling

hydrolase activity

cell junction

Adherens junction

229122_x_at C16orf35 chromosome 16 open reading frame 35 16 -75803, -75803 AI669063 16p13.3 Hs.19699 6

molecular_function

cellular_component

biological_process

 
227142_at PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 1 -6448738, -6448738, -6448738, -6448738, -6448738 AW274379 1p36.31 Hs.284232 Hs.619982 7

signal transducer activity

Rho guanyl-nucleotide exchange factor activity

intracellular

cytoplasm

cell death

regulation of Rho protein signal transduction

positive regulation of I-kappaB kinase/NF-kappaB cascade

perinuclear region of cytoplasm

 
231478_at -1.251 4.573 -2.647 1.816e-02 0.479 -3.061 PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) 19 -18179770, -18179770, -18179770 AI051127 19p13.11 Hs.132584 13

3',5'-cyclic-AMP phosphodiesterase activity

signal transduction

hydrolase activity

Purine metabolism

227072_at RTTN rotatin 18 -65822020 BG167480 18q22.2 Hs.654809 3

binding

multicellular organismal development

determination of left/right symmetry

 
201808_s_at ENG endoglin 9 -129617111 BE732652 9q33-q34.1 Hs.76753 164

chronological cell aging

patterning of blood vessels

heart looping

transmembrane receptor activity

transforming growth factor beta receptor, cytoplasmic mediator activity

type II transforming growth factor beta receptor binding

type II transforming growth factor beta receptor binding

protein binding

galactose binding

glycosaminoglycan binding

glycosaminoglycan binding

extracellular space

membrane fraction

cell adhesion

heart development

external side of plasma membrane

positive regulation of pathway-restricted SMAD protein phosphorylation

membrane

integral to membrane

regulation of transforming growth factor beta receptor signaling pathway

central nervous system vasculogenesis

positive regulation of BMP signaling pathway

negative regulation of protein amino acid autophosphorylation

type I transforming growth factor beta receptor binding

type I transforming growth factor beta receptor binding

protein homodimerization activity

regulation of transcription

activin binding

smooth muscle tissue development

artery morphogenesis

venous blood vessel morphogenesis

transforming growth factor beta binding

transforming growth factor beta receptor complex

 
204212_at ACOT8 acyl-CoA thioesterase 8 20 -43903767 NM_005469 20q13.12 Hs.444776 18

carboxylesterase activity

protein binding

peroxisome

lipid metabolic process

acyl-CoA metabolic process

peroxisome organization

acyl-CoA thioesterase activity

hydrolase activity

choloyl-CoA hydrolase activity

interspecies interaction between organisms

 
219706_at 0.380 6.858 2.587 2.045e-02 0.495 -3.161 C20orf29 chromosome 20 open reading frame 29 20 3749202 NM_018347 20p13 Hs.104806 4    
218206_x_at SCAND1 SCAN domain containing 1 20 -34004959 NM_016558 20q11.1-q11.23 Hs.584909 14

transcription factor activity

transcription coactivator activity

nucleus

regulation of transcription, DNA-dependent

identical protein binding

 
237142_at PPARA peroxisome proliferator-activated receptor alpha 22 44925162 AI939604 22q12-q13.1 22q13.31 Hs.103110 Hs.710044 260

response to hypoxia

transcription factor activity

steroid hormone receptor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

lipid metabolic process

drug binding

zinc ion binding

epidermis development

negative regulation of specific transcription from RNA polymerase II promoter

negative regulation of foam cell differentiation

negative regulation of foam cell differentiation

negative regulation of receptor biosynthetic process

negative regulation of cholesterol storage

negative regulation of sequestering of triglyceride

fatty acid transport

transcription activator activity

regulation of fatty acid metabolic process

positive regulation of fatty acid beta-oxidation

wound healing

sequence-specific DNA binding

positive regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

metal ion binding

PPAR signaling pathway

Adipocytokine signaling pathway

212881_at -0.340 5.743 -2.920 1.044e-02 0.418 -2.593 PIAS4 protein inhibitor of activated STAT, 4 19 3958748 AK022481 19p13.3 Hs.105779 39

negative regulation of transcription from RNA polymerase II promoter

DNA binding

transcription corepressor activity

protein binding

nucleus

nucleus

zinc ion binding

Wnt receptor signaling pathway

nuclear matrix

negative regulation of transcription

negative regulation of transcription

SUMO ligase activity

modification-dependent protein catabolic process

positive regulation of protein sumoylation

metal ion binding

Ubiquitin mediated proteolysis

Jak-STAT signaling pathway

Pathways in cancer

Small cell lung cancer

219232_s_at 0.410 3.685 2.401 2.955e-02 0.536 -3.469 EGLN3 egl nine homolog 3 (C. elegans) 14 -33463171 NM_022073 14q13.1 Hs.135507 26

iron ion binding

protein binding

nucleus

cytoplasm

apoptosis

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

L-ascorbic acid binding

metal ion binding

oxidation reduction

Pathways in cancer

Renal cell carcinoma

233339_s_at -0.283 4.975 -2.907 1.071e-02 0.420 -2.615 ARID1B AT rich interactive domain 1B (SWI1-like) 6 157140777 AW024272 6q25.1 Hs.291587 Hs.714899 22

DNA binding

DNA binding

transcription coactivator activity

protein binding

intracellular

nucleus

nucleolus

cytoplasm

SWI/SNF complex

chromatin modification

regulation of transcription

chromatin-mediated maintenance of transcription

 
212006_at 0.351 8.019 2.729 1.539e-02 0.458 -2.921 UBXN4 UBX domain protein 4 2 136215658 AU149908 2q21.3 Hs.591242 12

protein binding

nucleus

nuclear envelope

endoplasmic reticulum

response to unfolded protein

membrane

integral to membrane

 
223082_at SH3KBP1 SH3-domain kinase binding protein 1 X -19462003, -19462003 AF230904 Xp22.1-p21.3 Hs.719268 58

molecular_function

protein binding

nucleus

nucleolus

cytoplasm

cytosol

cytoskeleton

plasma membrane

focal adhesion

endocytosis

apoptosis

cell-cell signaling

SH3 domain binding

synaptosome

cell junction

cytoplasmic vesicle

synapse

Endocytosis

1565797_at -0.204 4.239 -2.163 4.690e-02 0.583 -3.851 DUOX1 dual oxidase 1 15 43209483 BC030522 15q15.3 Hs.272813 28

peroxidase activity

calcium ion binding

plasma membrane

response to oxidative stress

electron carrier activity

integral to membrane

NAD(P)H oxidase activity

apical plasma membrane

oxidoreductase activity

cytokine-mediated signaling pathway

heme binding

cuticle development

hormone biosynthetic process

superoxide anion generation

hydrogen peroxide catabolic process

FAD binding

NADP or NADPH binding

hydrogen peroxide biosynthetic process

response to cAMP

response to cAMP

oxidation reduction

 
204843_s_at PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 3 -48763096 NM_004157 3p21.3-p21.2 Hs.631923 81

nucleotide binding

regulation of protein amino acid phosphorylation

membrane fraction

cytoplasm

plasma membrane

cAMP-dependent protein kinase complex

cAMP-dependent protein kinase regulator activity

hormone-mediated signaling

cAMP binding

Apoptosis

Insulin signaling pathway

201133_s_at PJA2 praja ring finger 2 5 -108698308 AA142966 5q21.3 Hs.483036 Hs.592564 10

protein binding

cytoplasm

endoplasmic reticulum

Golgi apparatus

plasma membrane

zinc ion binding

postsynaptic density

ligase activity

modification-dependent protein catabolic process

cell junction

synapse

postsynaptic membrane

metal ion binding

 
227144_at C22orf9 chromosome 22 open reading frame 9 22 -43966786, -43966786 AA476916 22q13.31 Hs.592207 10

protein binding

 
223919_at TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 11 -128310479 AB045831 11q24 Hs.160953 Hs.711194 11

molecular_function

mitochondrion

apoptosis

p53 signaling pathway

229341_at 0.240 4.825 2.758 1.449e-02 0.447 -2.870 TFCP2L1 transcription factor CP2-like 1 2 -121690635 AW195353 2q14 Hs.156471 8

negative regulation of transcription from RNA polymerase II promoter

cell morphogenesis

epithelial cell maturation

transcription factor activity

transcription corepressor activity

nucleus

cytoplasm

steroid biosynthetic process

cytoplasm organization

salivary gland development

female pregnancy

determination of adult lifespan

membrane

general transcriptional repressor activity

regulation of transcription

positive regulation of growth

 
241221_at -0.282 4.792 -2.668 1.741e-02 0.471 -3.025 SEC14L3 SEC14-like 3 (S. cerevisiae) 22 -29185216 BE644691 22q12.2 Hs.505601 6

transporter activity

intracellular

transport

lipid binding

 
226616_s_at NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa 21 43186446 NM_021075 21q22.3 Hs.473937 16

mitochondrion

mitochondrial inner membrane

mitochondrial respiratory chain complex I

mitochondrial electron transport, NADH to ubiquinone

transport

NADH dehydrogenase (ubiquinone) activity

membrane

electron transport chain

respiratory chain

Oxidative phosphorylation

Metabolic pathways

Alzheimer's disease

Parkinson's disease

Huntington's disease

210154_at 0.562 6.228 2.613 1.941e-02 0.489 -3.117 ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 18 46659432 M55905 18q21 6p25-p24 Hs.233119 24

malate dehydrogenase (decarboxylating) activity

binding

mitochondrion

mitochondrial matrix

malate metabolic process

electron carrier activity

oxidoreductase activity

malate dehydrogenase (oxaloacetate-decarboxylating) activity

metal ion binding

NAD or NADH binding

oxidation reduction

Pyruvate metabolism

Biosynthesis of phenylpropanoids

Biosynthesis of alkaloids derived from terpenoid and polyketide

200984_s_at CD59 CD59 molecule, complement regulatory protein 11 -33681131, -33681131, -33681131 X16447 11p13 Hs.278573 Hs.709466 Hs.710641 107

protein binding

extracellular region

membrane fraction

plasma membrane

cell surface receptor linked signal transduction

blood coagulation

anchored to membrane

anchored to external side of plasma membrane

Complement and coagulation cascades

Hematopoietic cell lineage

221530_s_at -0.877 9.452 -3.123 6.883e-03 0.370 -2.239 BHLHE41 basic helix-loop-helix family, member e41 12 -26164227 BE857425 12p11.23-p12.1 Hs.177841 15

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

cell proliferation

organ morphogenesis

cell differentiation

Circadian rhythm - mammal

216167_at LRRN2 leucine rich repeat neuronal 2 1 -202852925, -202852925 AK024867 1q32.1 Hs.26312 7

receptor activity

protein binding

cell adhesion

signal transduction

membrane

integral to membrane

 
230394_at TCP10L t-complex 10 (mouse)-like 21 -32869022 AI336920 21q22.11 Hs.42034 11    
214270_s_at 0.435 4.051 2.813 1.299e-02 0.432 -2.778 MAPRE3 microtubule-associated protein, RP/EB family, member 3 2 27047028 AI885178 2p23.3-p23.1 Hs.515860 13

small GTPase regulator activity

cytoplasm

microtubule

cell cycle

mitosis

microtubule binding

midbody

positive regulation of gene-specific transcription

cell division

 
210349_at -0.245 3.436 -2.278 3.760e-02 0.564 -3.669 CAMK4 calcium/calmodulin-dependent protein kinase IV 5 110587980 L24959 5q21.3 Hs.591269 46

nucleotide binding

calmodulin-dependent protein kinase activity

calcium ion binding

calmodulin binding

ATP binding

nucleus

nucleolus

cytoplasm

protein amino acid phosphorylation

signal transduction

transferase activity

Calcium signaling pathway

Long-term potentiation

Neurotrophin signaling pathway

210335_at 0.328 2.782 2.460 2.630e-02 0.521 -3.372 RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 12 -84722461 AF056209 12q21.31 Hs.527881 4

transporter activity

protein binding

endosome

cytosol

protein targeting

signal transduction

trans-Golgi network transport vesicle membrane

endosome transport

 
205926_at IL27RA interleukin 27 receptor, alpha 19 14003261 NM_004843 19p13.11 Hs.132781 12

positive regulation of T-helper 1 type immune response

negative regulation of T-helper 2 type immune response

transmembrane receptor activity

protein binding

integral to plasma membrane

immune response

cell surface receptor linked signal transduction

membrane

positive regulation of interferon-gamma production

interleukin-27 receptor activity

regulation of isotype switching to IgG isotypes

defense response to Gram-positive bacterium

 
205189_s_at FANCC Fanconi anemia, complementation group C 9 -96901156 NM_000136 9q22.3 Hs.494529 77

protein binding

nucleus

cytoplasm

cytosol

DNA repair

protein complex assembly

response to DNA damage stimulus

 
215355_at -0.257 2.647 -2.361 3.198e-02 0.545 -3.535 POU2F3 POU class 2 homeobox 3 11 119616160 AI686582 11q23.3 Hs.227115 13

transcription factor activity

nucleus

transcription factor complex

epidermis development

keratinocyte differentiation

wound healing

sequence-specific DNA binding

positive regulation of transcription from RNA polymerase II promoter

protein dimerization activity

 
218360_at 0.458 6.059 3.739 1.933e-03 0.273 -1.158 RAB22A RAB22A, member RAS oncogene family 20 56318176 NM_020673 20q13.32 Hs.529044 14

nucleotide binding

GTPase activity

protein binding

protein binding

GTP binding

early endosome

plasma membrane

endocytosis

endosome organization

small GTPase mediated signal transduction

protein transport

Endocytosis

221499_s_at STX16 syntaxin 16 20 56659733, 56659733 AK026970 20q13.32 Hs.307913 14

SNAP receptor activity

cytoplasm

microsome

Golgi apparatus

intracellular protein transport

intra-Golgi vesicle-mediated transport

membrane

integral to membrane

vesicle-mediated transport

SNARE complex

retrograde transport, endosome to Golgi

SNARE interactions in vesicular transport

215777_at -0.196 4.405 -2.134 4.950e-02 0.590 -3.895 IGLV4-60 immunoglobulin lambda variable 4-60 22   AW405975 22q11.2   5    
224714_at 0.413 7.692 2.483 2.516e-02 0.514 -3.334 MKI67IP MKI67 (FHA domain) interacting nucleolar phosphoprotein 2 -122200991 AL542544 2q14.3 Hs.367842 8

nucleotide binding

condensed nuclear chromosome

condensed nuclear chromosome

RNA binding

RNA binding

protein binding

protein binding

nucleus

nucleoplasm

nucleoplasm

nucleolus

nucleolus

cytoplasm

cytoplasm

protein complex assembly

rRNA transcription

rRNA metabolic process

 
208723_at USP11 ubiquitin specific peptidase 11 X 46977257 BC000350 Xp11.23 Hs.171501 18

cysteine-type endopeptidase activity

ubiquitin thiolesterase activity

ubiquitin-specific protease activity

protein binding

nucleus

ubiquitin-dependent protein catabolic process

peptidase activity

 
209531_at 0.283 7.331 2.130 4.991e-02 0.591 -3.902 GSTZ1 glutathione transferase zeta 1 14 76856982, 76857458 BC001453 14q24.3 Hs.655292 31

glutathione transferase activity

glutathione peroxidase activity

protein binding

cytoplasm

mitochondrion

cytosol

L-phenylalanine catabolic process

tyrosine catabolic process

aromatic amino acid family metabolic process

maleylacetoacetate isomerase activity

maleylacetoacetate isomerase activity

transferase activity

isomerase activity

Tyrosine metabolism

Glutathione metabolism

Styrene degradation

Metabolism of xenobiotics by cytochrome P450

Drug metabolism - cytochrome P450

Metabolic pathways

241512_at SPATC1 spermatogenesis and centriole associated 1 8 145158569 AI026805 8q24.3 Hs.97726 3

cytoplasm

centrosome

 
212189_s_at COG4 component of oligomeric golgi complex 4 16 -69071972 AK022874 16q22.1 Hs.208680 11

protein binding

Golgi apparatus

protein transport

membrane

Golgi transport complex

 
220761_s_at 0.323 6.337 2.437 2.755e-02 0.526 -3.410 TAOK3 TAO kinase 3 12 -117071988 NM_016281 12q Hs.644420 10

nucleotide binding

protein serine/threonine kinase activity

protein kinase inhibitor activity

ATP binding

cytoplasm

mitochondrion

plasma membrane

transferase activity

negative regulation of JNK cascade

positive regulation of JNK cascade

protein amino acid autophosphorylation

MAPK signaling pathway

206571_s_at 0.468 6.053 2.854 1.194e-02 0.426 -2.706 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2 101680919 NM_004834 2q11.2-q12 Hs.719073 22

nucleotide binding

protein serine/threonine kinase activity

small GTPase regulator activity

ATP binding

cellular_component

protein amino acid phosphorylation

response to stress

protein kinase cascade

transferase activity

MAPK signaling pathway

204648_at NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) 1 151917787 NM_000906 1q21-q22 Hs.490330 50

nucleotide binding

guanylate cyclase activity

protein tyrosine kinase activity

receptor activity

ATP binding

GTP binding

integral to plasma membrane

cGMP biosynthetic process

protein amino acid phosphorylation

cell surface receptor linked signal transduction

intracellular signaling cascade

regulation of blood pressure

peptide receptor activity, G-protein coupled

membrane

negative regulation of angiogenesis

diuresis

natriuresis

negative regulation of cell growth

chloride ion binding

regulation of vasodilation

hormone binding

regulation of vascular permeability

Purine metabolism

Vascular smooth muscle contraction

227649_s_at SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 1 204582822, 204582822 AU144000 1q32.1 Hs.497575 7

GTPase activator activity

intracellular

signal transduction

Axon guidance

223255_at G2E3 G2/M-phase specific E3 ubiquitin ligase 14 30098079 AA642341 14q12 Hs.509008 Hs.605081 13

protein polyubiquitination

blastocyst development

ubiquitin-protein ligase activity

protein binding

intracellular

nucleus

nucleolus

cytoplasm

Golgi apparatus

protein modification process

multicellular organismal development

zinc ion binding

ligase activity

acid-amino acid ligase activity

modification-dependent protein catabolic process

negative regulation of apoptosis

metal ion binding

 
243645_at NFASC neurofascin homolog (chicken) 1 203064404, 203064404, 203179976 AW102637 1q32.1 Hs.13349 28

protein binding

plasma membrane

cell adhesion

integral to membrane

Cell adhesion molecules (CAMs)

238885_at 0.244 4.757 2.851 1.200e-02 0.426 -2.711 KIAA1549 KIAA1549 7 -138166666 AV704797 7q34 Hs.605380 5

membrane

integral to membrane

 
203797_at VSNL1 visinin-like 1 2 17585287 AF039555 2p24.3 Hs.444212 29

calcium ion binding

 
213376_at 0.379 6.831 2.442 2.728e-02 0.526 -3.402 ZBTB1 zinc finger and BTB domain containing 1 14 64041044, 64041044 AI656706 14q23.3 Hs.655536 6

DNA binding

protein binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
203556_at ZHX2 zinc fingers and homeoboxes 2 8 123863081 NM_014943 8q24.13 Hs.658443 Hs.719079 12

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

protein binding

intracellular

nucleus

mRNA catabolic process

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
201090_x_at 0.585 10.198 2.734 1.522e-02 0.457 -2.912 TUBA1B tubulin, alpha 1b 12 -47807832 NM_006082 12q13.12 Hs.524390 Hs.719075 42

nucleotide binding

microtubule cytoskeleton organization

GTPase activity

structural constituent of cytoskeleton

protein binding

GTP binding

microtubule

microtubule-based movement

protein complex

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

213646_x_at 0.621 10.324 2.839 1.231e-02 0.427 -2.732 TUBA1B tubulin, alpha 1b 12 -47807832 BE300252 12q13.12 Hs.524390 Hs.719075 42

nucleotide binding

microtubule cytoskeleton organization

GTPase activity

structural constituent of cytoskeleton

protein binding

GTP binding

microtubule

microtubule-based movement

protein complex

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

213225_at PPM1B protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform 2 44249503, 44249503, 44249503 AJ271832 2p21 Hs.416769 17

magnesium ion binding

protein serine/threonine phosphatase activity

protein binding

protein amino acid dephosphorylation

protein serine/threonine phosphatase complex

hydrolase activity

manganese ion binding

MAPK signaling pathway

216470_x_at -0.239 4.000 -2.644 1.827e-02 0.480 -3.066 PRSS1 protease, serine, 1 (trypsin 1) 7 142136892 AF009664 7q32-qter 7q34 Hs.622865 Hs.654498 100

serine-type endopeptidase activity

calcium ion binding

protein binding

extracellular region

extracellular space

proteolysis

digestion

peptidase activity

Neuroactive ligand-receptor interaction

202503_s_at 0.761 3.502 2.401 2.956e-02 0.536 -3.469 KIAA0101 KIAA0101 15 -62444263 NM_014736 15q22.31 Hs.81892 11

nucleus

mitochondrion

 
201832_s_at USO1 USO1 homolog, vesicle docking protein (yeast) 4 76868852 NM_003715 4q21.1 Hs.292689 34

Golgi membrane

protein binding

cytoplasm

microsome

Golgi apparatus

cytosol

intracellular protein transport

protein transporter activity

membrane

vesicle-mediated transport

vesicle fusion with Golgi apparatus

perinuclear region of cytoplasm

 
215767_at ZNF804A zinc finger protein 804A 2 185171337 AF052145 2q32.1 Hs.159528 8

intracellular

zinc ion binding

metal ion binding

 
215509_s_at BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 2 -111111882 AL137654 2q14 Hs.469649 55

nucleotide binding

condensed chromosome kinetochore

condensed nuclear chromosome, centromeric region

protein serine/threonine kinase activity

ATP binding

nucleus

spindle pole body

protein amino acid phosphorylation

cell cycle

mitosis

mitotic cell cycle spindle assembly checkpoint

cell proliferation

transferase activity

cell division

Cell cycle

224905_at 0.463 6.667 3.030 8.339e-03 0.387 -2.402 WDR26 WD repeat domain 26 1 -222639467 AA482548 1q42.11-q42.12 Hs.497873 8

cytoplasm

 
233842_x_at C20orf43 chromosome 20 open reading frame 43 20 54477053 AK000586 20q13.31 Hs.517134 10

molecular_function

cellular_component

biological_process

 
225003_at 0.326 8.568 2.518 2.347e-02 0.507 -3.276 TMEM205 transmembrane protein 205 19 -11314451 BF343862 19p13.2 Hs.8036 2

membrane

integral to membrane

 
225993_at 0.262 5.505 2.162 4.694e-02 0.583 -3.852 EARS2 glutamyl-tRNA synthetase 2, mitochondrial (putative) 16 -23440834 AL520723 16p12.2 Hs.620541 6

nucleotide binding

RNA binding

glutamate-tRNA ligase activity

ATP binding

cytoplasm

mitochondrion

mitochondrial matrix

glutamyl-tRNA aminoacylation

ligase activity

Porphyrin and chlorophyll metabolism

Aminoacyl-tRNA biosynthesis

Metabolic pathways

201829_at NET1 neuroepithelial cell transforming 1 10 5444517, 5478545 AW263232 10p15 Hs.25155 19

regulation of cell growth

guanyl-nucleotide exchange factor activity

Rho guanyl-nucleotide exchange factor activity

cellular_component

intracellular

nucleus

cytoplasm

intracellular signaling cascade

regulation of Rho protein signal transduction

 
219824_at -0.213 5.833 -2.237 4.066e-02 0.570 -3.734 SLC13A4 solute carrier family 13 (sodium/sulfate symporters), member 4 7 -135016526 NM_012450 7q33 Hs.200022 Hs.490241 5

transporter activity

integral to plasma membrane

ion transport

sodium ion transport

sulfate transport

symporter activity

sodium:sulfate symporter activity

membrane

sodium ion binding

 
1566108_at -0.242 3.203 -2.615 1.933e-02 0.489 -3.113 MYNN myoneurin 3 170973546 AK056483 3q26.2 Hs.507025 6

transcription factor activity

protein binding

intracellular

nucleus

transcription, DNA-dependent

zinc ion binding

regulation of transcription

metal ion binding

 
208977_x_at 0.507 8.862 2.198 4.381e-02 0.578 -3.795 TUBB2C tubulin, beta 2C 9 139255531 BC004188 9q34 Hs.433615 25

nucleotide binding

GTPase activity

structural molecule activity

GTP binding

cytoskeleton

microtubule

cell motion

microtubule-based movement

natural killer cell mediated cytotoxicity

MHC class I protein binding

protein complex

unfolded protein binding

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

211750_x_at 0.599 9.757 2.576 2.090e-02 0.497 -3.179 TUBA1C tubulin, alpha 1c 12 47945131 BC005946 12q12-q14 Hs.719091 19

nucleotide binding

GTPase activity

structural molecule activity

protein binding

GTP binding

microtubule

microtubule-based movement

protein complex

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

227127_at TMEM110 transmembrane protein 110 3 -52848937 BF222855 3p21.1 Hs.705605 2

molecular_function

cellular_component

biological_process

membrane

integral to membrane

 
221023_s_at KCNH6 potassium voltage-gated channel, subfamily H (eag-related), member 6 17 58954426, 58954426 NM_030779 17q23.3 Hs.591177 6

voltage-gated ion channel activity

voltage-gated potassium channel activity

regulation of transcription, DNA-dependent

ion transport

potassium ion transport

signal transduction

membrane

integral to membrane

potassium ion binding

 
212222_at 0.504 8.865 3.310 4.685e-03 0.336 -1.911 PSME4 proteasome (prosome, macropain) activator subunit 4 2 -53944707 AU143855 2p16.2 Hs.413801 30

binding

nucleus

cytosol

multicellular organismal development

spermatogenesis

nuclear speck

cell differentiation

protein complex

Proteasome

206882_at SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 19 -14921990 NM_005071 19p13.12 Hs.515217 11

L-glutamate transmembrane transporter activity

membrane fraction

integral to plasma membrane

transport

dicarboxylic acid transport

synaptic transmission

anion transmembrane transporter activity

L-aspartate transmembrane transporter activity

symporter activity

aspartate transport

L-glutamate transport

membrane

sodium:dicarboxylate symporter activity

regulation of membrane potential

 
219748_at TREML2 triggering receptor expressed on myeloid cells-like 2 6 -41265529 NM_024807 6p21.1 Hs.164797 6

receptor activity

protein binding

plasma membrane

cell surface

integral to membrane

T cell activation

 
218578_at CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 1 191357710 NM_024529 1q25 Hs.378996 Hs.576497 59

protein binding

nucleus

transcription

cell cycle

histone monoubiquitination

Cdc73/Paf1 complex

histone H2B ubiquitination

 
210809_s_at 2.145 4.870 2.796 1.344e-02 0.437 -2.806 POSTN periostin, osteoblast specific factor 13 -37034719 D13665 13q13.3 Hs.136348 38

skeletal system development

protein binding

extracellular region

proteinaceous extracellular matrix

cell adhesion

heparin binding

 
201362_at 0.635 6.719 2.935 1.012e-02 0.415 -2.566 IVNS1ABP influenza virus NS1A binding protein 1 -183532144 AF205218 1q25.1-q31.1 Hs.497183 9

protein binding

nucleus

nucleoplasm

transcription factor complex

spliceosomal complex

cytoplasm

cytoskeleton

transcription from RNA polymerase III promoter

RNA splicing

response to virus

interspecies interaction between organisms

 
219958_at C20orf46 chromosome 20 open reading frame 46 20 -1109214 NM_018354 20p13 Hs.516834 4

protein binding

membrane

integral to membrane

 
213996_at YPEL1 yippee-like 1 (Drosophila) 22 -20381825 NM_013313 22q11.2 Hs.517436 7

nucleus

 
222568_at 0.360 6.088 3.301 4.776e-03 0.338 -1.928 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 128565223, 128565251 AI672492 2q14.3 Hs.598715 Hs.719174 10

UDP-glucose:glycoprotein glucosyltransferase activity

endoplasmic reticulum

endoplasmic reticulum lumen

ER-Golgi intermediate compartment

protein amino acid glycosylation

transferase activity, transferring glycosyl groups

unfolded protein binding

'de novo' posttranslational protein folding

 
226926_at DMKN dermokine 19 -40686045, -40679961, -40679961, -40679961 AA706316 19q13.12 Hs.417795 7

extracellular region

extracellular space

 
200811_at 0.422 9.328 2.492 2.473e-02 0.513 -3.320 CIRBP cold inducible RNA binding protein 19 1220266, 1220266 NM_001280 19p13.3 Hs.634522 Hs.664127 17

nucleotide binding

RNA binding

protein binding

nucleus

nucleoplasm

response to cold

 
232235_at 0.625 2.882 2.815 1.291e-02 0.432 -2.773 DSEL dermatan sulfate epimerase-like 18 -63324798 AK021539 18q22.1 Hs.124673 6

membrane

integral to membrane

 
209251_x_at 0.586 9.843 2.532 2.283e-02 0.503 -3.253 TUBA1C tubulin, alpha 1c 12 47945131 BC004949 12q12-q14 Hs.719091 19

nucleotide binding

GTPase activity

structural molecule activity

protein binding

GTP binding

microtubule

microtubule-based movement

protein complex

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

219594_at NINJ2 ninjurin 2 12 -543722 NM_016533 12p13 Hs.656450 5

protein binding

integral to plasma membrane

cell adhesion

neuron adhesion

nervous system development

membrane

tissue regeneration

 
218637_at IMPACT Impact homolog (mouse) 18 20260606 NM_018439 18q11.2-q12.1 Hs.515317 6

molecular_function

cellular_component

regulation of translation

biological_process

 
232185_at C20orf132 chromosome 20 open reading frame 132 20 -35190637, -35163042 AL136172 20q11.22 Hs.349125 9    
209231_s_at DCTN5 dynactin 5 (p25) 16 23560307 AI038068 16p12.2 Hs.435941 7

cytoplasm

cytoskeleton

transferase activity

 
225369_at ESAM endothelial cell adhesion molecule 11 -124128228 AL573851 11q24.2 Hs.173840 11

protein binding

plasma membrane

adherens junction

tight junction

homophilic cell adhesion

integral to membrane

cell junction

Cell adhesion molecules (CAMs)

Leukocyte transendothelial migration

209834_at 0.315 5.962 2.271 3.807e-02 0.565 -3.679 CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 10 73394125 AB017915 10q22.1 Hs.158304 15

Golgi membrane

Golgi apparatus

carbohydrate metabolic process

sulfur metabolic process

sulfotransferase activity

chondroitin 6-sulfotransferase activity

membrane

integral to membrane

transferase activity

chondroitin sulfate biosynthetic process

Chondroitin sulfate biosynthesis

203775_at SLC25A13 solute carrier family 25, member 13 (citrin) 7 -95587468, -95587467 NM_014251 7q21.3 Hs.489190 31

transporter activity

L-glutamate transmembrane transporter activity

binding

calcium ion binding

mitochondrion

mitochondrial inner membrane

integral to plasma membrane

ATP biosynthetic process

transport

L-aspartate transmembrane transporter activity

aspartate transport

L-glutamate transport

membrane

malate-aspartate shuttle

cellular respiration

response to calcium ion

 
226336_at PPIA peptidylprolyl isomerase A (cyclophilin A) 7 44802765 T62044 7p13 Hs.356331 Hs.598115 164

peptidyl-prolyl cis-trans isomerase activity

extracellular region

nucleus

cytoplasm

cytosol

cytosol

protein folding

isomerase activity

provirus integration

initiation of viral infection

peptide binding

interspecies interaction between organisms

regulation of viral genome replication

regulation of viral genome replication

virion binding

unfolded protein binding

 
204218_at 0.220 7.419 2.140 4.891e-02 0.590 -3.886 C11orf51 chromosome 11 open reading frame 51 11 -71498280 NM_014042 11q13.4 Hs.38044 7

intracellular

 
203404_at 0.320 6.255 2.186 4.489e-02 0.581 -3.815 ARMCX2 armadillo repeat containing, X-linked 2 X -100796925 NM_014782 Xq21.33-q22.2 Hs.48924 7

binding

membrane

integral to membrane

 
210592_s_at 0.515 7.644 3.312 4.664e-03 0.336 -1.907 SAT1 spermidine/spermine N1-acetyltransferase 1 X 23711195 M55580 Xp22.1 Hs.28491 46

diamine N-acetyltransferase activity

protein binding

intracellular

cytoplasm

metabolic process

acyltransferase activity

transferase activity

Arginine and proline metabolism

Metabolic pathways

227118_s_at -0.285 4.432 -2.822 1.274e-02 0.431 -2.762 MRPS26 mitochondrial ribosomal protein S26 20 2974674 AA594308 20p13 Hs.18946 10

mitochondrion

mitochondrial small ribosomal subunit

ribosome

DNA damage response, detection of DNA damage

peptide biosynthetic process

 
214440_at NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 8 18072250, 18111897, 18123456 NM_000662 8p23.1-p21.3 Hs.591847 163

arylamine N-acetyltransferase activity

cytoplasm

cytosol

metabolic process

acetyltransferase activity

transferase activity

Caffeine metabolism

Drug metabolism - other enzymes

Metabolic pathways

208267_at TRPV5 transient receptor potential cation channel, subfamily V, member 5 7 -142315769 NM_019841 7q35 Hs.283369 34

ion channel activity

calcium channel activity

calcium ion binding

protein binding

plasma membrane

integral to plasma membrane

ion transport

calcium ion transport

calcium ion transport

apical plasma membrane

protein tetramerization

 
201305_x_at 0.596 8.368 3.247 5.339e-03 0.351 -2.023 ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 9 99785309 AV712577 9q22.32 Hs.715547 16

protein binding

nucleus

 
213086_s_at 0.433 8.418 2.295 3.638e-02 0.559 -3.642 CSNK1A1 casein kinase 1, alpha 1 5 -148855037 BF341845 5q32 Hs.529862 Hs.712555 53

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

cytosol

protein amino acid phosphorylation

Wnt receptor signaling pathway

transferase activity

Wnt signaling pathway

Hedgehog signaling pathway

229863_s_at 0.235 6.248 2.263 3.869e-02 0.567 -3.693 C3orf75 chromosome 3 open reading frame 75 3 -47512133 BE503382 3p21.31 Hs.311100 4

molecular_function

cellular_component

biological_process

 
235760_at 0.381 5.317 2.378 3.092e-02 0.542 -3.507 NSD1 nuclear receptor binding SET domain protein 1 5 176492685, 176493438 AI421972 5q35.2-q35.3 Hs.106861 36

negative regulation of transcription from RNA polymerase II promoter

chromatin binding

transcription corepressor activity

protein binding

nucleus

methyltransferase activity

zinc ion binding

chromatin modification

histone methylation

transferase activity

ligand-dependent nuclear receptor binding

estrogen receptor binding

histone methyltransferase activity (H4-K20 specific)

regulation of transcription

positive regulation of transcription, DNA-dependent

metal ion binding

retinoid X receptor binding

thyroid hormone receptor binding

histone methyltransferase activity (H3-K36 specific)

androgen receptor binding

Lysine degradation

201964_at SETX senataxin 9 -134126647 N64643 9q34.13 Hs.460317 24

nucleotide binding

DNA binding

DNA helicase activity

ATP binding

nucleus

nucleoplasm

nucleolus

cytoplasm

double-strand break repair

RNA processing

response to DNA damage stimulus

cell death

hydrolase activity

 
213027_at 0.334 6.765 2.386 3.046e-02 0.541 -3.494 TROVE2 TROVE domain family, member 2 1 191295375, 191295579, 191295579 AU146655 1q31 Hs.288178 24

RNA binding

protein binding

cytoplasm

transcription from RNA polymerase III promoter

ribonucleoprotein complex

Systemic lupus erythematosus

1554015_a_at 0.387 4.832 2.705 1.614e-02 0.461 -2.962 CHD2 chromodomain helicase DNA binding protein 2 15 91244554, 91244554 BC007347 15q26 Hs.220864 9

nucleotide binding

chromatin

DNA binding

chromatin binding

ATP-dependent DNA helicase activity

helicase activity

ATP binding

nucleus

chromatin assembly or disassembly

regulation of transcription from RNA polymerase II promoter

hydrolase activity

 
214613_at GPR3 G protein-coupled receptor 3 1 27591738 AW024085 1p36.1-p35 Hs.66542 10

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

activation of adenylate cyclase activity by G-protein signaling pathway

regulation of meiosis

 
1556907_at ZNF474 zinc finger protein 474 5 121493113 BM979960 5q23.2 Hs.646680 3

intracellular

zinc ion binding

metal ion binding

 
237639_at TMEM207 transmembrane protein 207 3 -191629139 AI913600 3q28 Hs.335321 2

membrane

integral to membrane

 
207702_s_at 0.550 4.869 3.828 1.609e-03 0.259 -1.003 MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 7 -77484309 NM_012301 7q21 Hs.603842 22

protein binding

plasma membrane

synaptosome

phosphatase binding

cell junction

synapse

Tight junction

1554386_at CST9 cystatin 9 (testatin) 20 -23531048 AF494536 20p11.21 Hs.698020 3

cysteine-type endopeptidase inhibitor activity

extracellular region

peptidase inhibitor activity

 
201635_s_at FXR1 fragile X mental retardation, autosomal homolog 1 3 182113145 AI990766 3q28 Hs.478407 30

RNA binding

nucleolus

cytoplasm

polysome

apoptosis

multicellular organismal development

muscle organ development

cell differentiation

 
213476_x_at TUBB3 tubulin, beta 3 16 88517245 AL565749 16q24.3 Hs.511743 41

nucleotide binding

GTPase activity

structural molecule activity

GTP binding

intracellular

microtubule

microtubule-based movement

mitosis

neuron differentiation

axon

protein complex

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

223928_s_at GUCA1C guanylate cyclase activator 1C 3 -110109331 AF110002 3q13.1 Hs.233363 4

calcium ion binding

signal transduction

visual perception

calcium sensitive guanylate cyclase activator activity

Olfactory transduction

225765_at 0.345 6.870 3.309 4.691e-03 0.336 -1.912 TNPO1 transportin 1 5 72148173, 72179685 AA527296 5q13.2 Hs.482497 58

protein import into nucleus, docking

protein import into nucleus, translocation

protein binding

nucleus

nuclear pore

cytoplasm

nuclear localization sequence binding

protein transporter activity

interspecies interaction between organisms

 
235106_at -0.321 3.272 -2.249 3.976e-02 0.568 -3.715 MAML2 mastermind-like 2 (Drosophila) 11 -95351087 AW847318 11q21 Hs.428214 17

transcription coactivator activity

nucleus

Notch signaling pathway

nuclear speck

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

Notch signaling pathway

239265_at 0.532 4.832 2.547 2.216e-02 0.499 -3.228 TMEM20 transmembrane protein 20 10 95643719 R56424 10q23.33 Hs.632085 4

membrane

integral to membrane

 
204587_at SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 X 129301727 NM_003951 Xq24 Hs.194686 13

binding

mitochondrion

mitochondrial inner membrane

integral to plasma membrane

transport

mitochondrial transport

aerobic respiration

membrane

 
227557_at SCARF2 scavenger receptor class F, member 2 22 -19108874 AI127800 22q11.21 Hs.474251 4

receptor activity

scavenger receptor activity

protein binding

cell adhesion

heterophilic cell adhesion

membrane

integral to membrane

 
205324_s_at FTSJ1 FtsJ homolog 1 (E. coli) X 48219492, 48221323 NM_012280 Xp11.23 Hs.23170 15

nucleic acid binding

rRNA processing

methyltransferase activity

transferase activity

rRNA methylation

methylation

 
1563947_a_at ERC1 ELKS/RAB6-interacting/CAST family member 1 12 970664 AK097177 12p13.3 Hs.655744 Hs.658200 19

protein binding

cytoplasm

Golgi apparatus

regulation of transcription, DNA-dependent

I-kappaB phosphorylation

multicellular organismal development

IkappaB kinase complex

protein transport

Rab GTPase binding

retrograde transport, endosome to Golgi

presynaptic membrane

leucine zipper domain binding

positive regulation of anti-apoptosis

positive regulation of NF-kappaB transcription factor activity

 
218311_at MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 2 -39329925 NM_003618 2p22.1 Hs.655750 7

nucleotide binding

protein serine/threonine kinase activity

small GTPase regulator activity

protein binding

ATP binding

protein amino acid phosphorylation

response to stress

protein kinase cascade

JNK cascade

transferase activity

MAPK signaling pathway

227684_at S1PR2 sphingosine-1-phosphate receptor 2 19 -10193108 AI032786 19p13.2 Hs.655405 25

activation of MAPK activity

lysosphingolipid and lysophosphatidic acid receptor activity

receptor activity

G-protein coupled receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

behavior

positive regulation of cell proliferation

lipid binding

integral to membrane

Neuroactive ligand-receptor interaction

230718_at HSF5 heat shock transcription factor family member 5 17 -53852527 AL137385 17q22 Hs.380061 1

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

sequence-specific DNA binding

 
204357_s_at 0.392 6.282 4.225 7.136e-04 0.211 -0.316 LIMK1 LIM domain kinase 1 7 73136091 NM_002314 7q11.23 Hs.647035 54

nucleotide binding

protein serine/threonine kinase activity

protein tyrosine kinase activity

protein binding

ATP binding

nucleus

cytoplasm

focal adhesion

protein amino acid phosphorylation

signal transduction

Rho protein signal transduction

nervous system development

zinc ion binding

transferase activity

actin cytoskeleton organization

positive regulation of axon extension

metal ion binding

protein heterodimerization activity

Axon guidance

Fc gamma R-mediated phagocytosis

Regulation of actin cytoskeleton

205641_s_at TRADD TNFRSF1A-associated via death domain 16 -65745589 NM_003789 16q22 Hs.460996 68

signal transducer activity

cytoplasm

cytosol

cytoskeleton

induction of apoptosis

signal transduction

activation of pro-apoptotic gene products

intermediate filament binding

kinase binding

tumor necrosis factor-mediated signaling pathway

identical protein binding

positive regulation of I-kappaB kinase/NF-kappaB cascade

receptor complex

positive regulation of hair follicle development

molecular adaptor activity

death domain binding

Apoptosis

RIG-I-like receptor signaling pathway

Adipocytokine signaling pathway

226300_at 0.377 6.938 2.919 1.046e-02 0.418 -2.595 MED19 mediator complex subunit 19 11 -57227762 BF109807 11q12.1 Hs.43619 9

protein binding

nucleus

regulation of transcription from RNA polymerase II promoter

RNA polymerase II transcription mediator activity

regulation of transcription

 
234485_at -0.340 4.785 -2.527 2.307e-02 0.505 -3.262 LOC340947 similar to eukaryotic translation initiation factor 3 subunit 6 interacting protein 10   AL117339 10p11.1 Hs.164084      
228345_at CHIC1 cysteine-rich hydrophobic domain 1 X 72699708 AI745136 Xq13-q21 Hs.496323 5

plasma membrane

cytoplasmic vesicle

 
244682_at -0.278 2.545 -2.951 9.806e-03 0.409 -2.539 CAMSAP1 calmodulin regulated spectrin-associated protein 1 9 -137840153 H11471 9q34.3 Hs.522493 2    
227416_s_at ZCRB1 zinc finger CCHC-type and RNA binding motif 1 12 -40992154 BE265803 12q12 Hs.496279 5

nucleotide binding

RNA binding

nucleus

nucleoplasm

U12-type spliceosomal complex

mRNA processing

zinc ion binding

RNA splicing

metal ion binding

 
225212_at -1.093 7.631 -2.581 2.068e-02 0.497 -3.170 SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 9 129870299, 129893948, 129900637, 129900656 BC005163 9q34.11 Hs.5476 6

binding

calcium ion binding

mitochondrion

mitochondrial inner membrane

transport

membrane

integral to membrane

 
219042_at LZTS1 leucine zipper, putative tumor suppressor 1 8 -20147956 NM_021020 8p22 Hs.521432 11

transcription factor activity

protein binding

nucleus

cytoplasm

Golgi apparatus

plasma membrane

transcription

regulation of transcription, DNA-dependent

cell cycle

postsynaptic density

cell junction

cell projection

dendritic spine

synapse

postsynaptic membrane

 
214334_x_at DAZAP2 DAZ associated protein 2 12 49918774, 49918774 N34846 12q12 Hs.369761 15

protein binding

WW domain binding

 
228865_at C1orf116 chromosome 1 open reading frame 116 1 -205258488 AA622392 1q32.1-q32.2 Hs.32417 6

receptor activity

cytoplasm

 
225229_at 0.429 7.612 2.188 4.467e-02 0.580 -3.811 AFF4 AF4/FMR2 family, member 4 5 -132238969 AL044396 5q31 Hs.519313 Hs.664840 10

transcription factor activity

nucleus

transcription from RNA polymerase II promoter

regulation of transcription

 
208752_x_at 0.351 9.727 2.194 4.413e-02 0.579 -3.801 NAP1L1 nucleosome assembly protein 1-like 1 12 -74724938 AI888672 12q21.2 Hs.524599 Hs.695185 17

protein binding

nucleus

chromatin assembly complex

DNA replication

nucleosome assembly

positive regulation of cell proliferation

melanosome

 
242931_at LONRF3 LON peptidase N-terminal domain and ring finger 3 X 117992740 AI218358 Xq24 Hs.144266 6

ATP-dependent peptidase activity

protein binding

proteolysis

zinc ion binding

metal ion binding

 
203244_at PEX5 peroxisomal biogenesis factor 5 12 7233025, 7233548, 7234224 NM_000319 12p13.31 Hs.567327 45

protein binding

cytoplasm

peroxisome

protein transport

membrane

 
206444_at PDE1B phosphodiesterase 1B, calmodulin-dependent 12 53229670 NM_000924 12q13 Hs.530871 11

calmodulin-dependent cyclic-nucleotide phosphodiesterase activity

calmodulin binding

cytoplasm

apoptosis

signal transduction

locomotory behavior

visual learning

hydrolase activity

Purine metabolism

Calcium signaling pathway

206168_at -0.179 4.861 -2.426 2.812e-02 0.529 -3.428 ZC3H7B zinc finger CCCH-type containing 7B 22 40027512 NM_025013 22q13.2 Hs.592188 12

nucleic acid binding

protein binding

intracellular

nucleus

zinc ion binding

interspecies interaction between organisms

metal ion binding

 
1553425_at -0.267 4.901 -2.852 1.199e-02 0.426 -2.710 WDR65 WD repeat domain 65 1 43410612 NM_152498 1p34.2 Hs.647644 6

membrane

integral to membrane

 
224856_at 1.283 8.312 3.432 3.644e-03 0.314 -1.697 FKBP5 FK506 binding protein 5 6 -35656311, -35649339, -35649339, -35649339 W86302 6p21.3-p21.2 Hs.407190 50

peptidyl-prolyl cis-trans isomerase activity

FK506 binding

nucleus

cytoplasm

protein folding

isomerase activity

heat shock protein binding

 
203003_at -0.301 6.833 -2.437 2.755e-02 0.526 -3.411 MEF2D myocyte enhancer factor 2D 1 -154700142 AL530331 1q12-q23 Hs.314327 35

transcription factor activity

nucleus

nucleolus

cytoplasm

regulation of transcription, DNA-dependent

apoptosis

multicellular organismal development

nervous system development

muscle organ development

cell differentiation

sequence-specific DNA binding

 
202646_s_at CSDE1 cold shock domain containing E1, RNA-binding 1 -115061060, -115061060, -115061059 AA167775 1p22 Hs.69855 25

DNA binding

RNA binding

protein binding

cytoplasm

regulation of transcription, DNA-dependent

male gonad development

 
214705_at INADL InaD-like (Drosophila) 1 61980736 AJ001306 1p31.3 Hs.478125 24

protein binding

cellular_component

plasma membrane

tight junction

intracellular signaling cascade

apical plasma membrane

cell junction

Tight junction

59644_at 0.353 3.638 2.404 2.942e-02 0.536 -3.465 BMP2K BMP2 inducible kinase 4 79916555, 79916555 AI735391 4q21.21 Hs.146551 11

nucleotide binding

protein serine/threonine kinase activity

ATP binding

nucleus

protein amino acid phosphorylation

transferase activity

 
202733_at 0.540 6.211 3.371 4.129e-03 0.323 -1.804 P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 5 -131556204, -131556202, -131556202 NM_004199 5q31 Hs.519568 14

procollagen-proline 4-dioxygenase activity

iron ion binding

protein binding

endoplasmic reticulum

endoplasmic reticulum lumen

electron carrier activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

L-ascorbic acid binding

metal ion binding

oxidation reduction

Arginine and proline metabolism

Metabolic pathways

220090_at -0.249 5.486 -2.205 4.322e-02 0.577 -3.784 CRNN cornulin 1 -150648342 NM_016190 1q21 Hs.242057 12

calcium ion binding

cytoplasm

response to unfolded protein

metabolic process

response to heat

membrane

membrane

cell-cell adhesion

 
223018_at 0.228 6.731 2.566 2.132e-02 0.497 -3.196 NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 16 -68333274 BC000050 16q22.3 Hs.271695 Hs.606475 8

protein binding

nucleus

zinc ion binding

metal ion binding

 
225528_at 0.244 7.653 2.186 4.484e-02 0.581 -3.814 IPO8 importin 8 12 -30673188 AU149465 12p11.21 Hs.505136 9

protein import into nucleus, docking

protein binding

nucleus

nuclear pore

cytoplasm

intracellular protein transport

signal transduction

Ran GTPase binding

protein transporter activity

 
205155_s_at SPTBN2 spectrin, beta, non-erythrocytic 2 11 -66209296 NM_006946 11q13 Hs.26915 18

actin binding

structural constituent of cytoskeleton

cytoplasm

cytoskeleton

cell cortex

spectrin

cell death

vesicle-mediated transport

actin filament capping

 
235014_at 0.511 7.048 3.523 3.020e-03 0.300 -1.538 LOC147727 hypothetical LOC147727 19 -10623538 BF345728 19p13.2 Hs.631616 2    
224779_s_at FAM96A family with sequence similarity 96, member A 15 -62151813 AI193090 15q22.31 Hs.439548 6

molecular_function

cellular_component

biological_process

 
212116_at 0.429 5.761 3.790 1.739e-03 0.267 -1.069 TRIM27 tripartite motif-containing 27 6 -28978757, -330309, -128126 NM_006510 6p22 Hs.440382 27

negative regulation of transcription from RNA polymerase II promoter

DNA binding

transmembrane receptor protein tyrosine kinase activity

protein binding

intracellular

membrane fraction

nucleus

nucleoplasm

cytoplasm

integral to plasma membrane

spermatogenesis

zinc ion binding

cell proliferation

nuclear membrane

regulation of transcription

negative regulation of gene expression, epigenetic

metal ion binding

protein trimerization

 
229772_at -0.252 5.237 -2.372 3.129e-02 0.543 -3.517 DEFB123 defensin, beta 123 20 29492071 AA789269 20q11.1 Hs.122509 4

extracellular region

defense response to bacterium

 
214207_s_at CARD10 caspase recruitment domain family, member 10 22 -36216345 AW024347 22q13.1 Hs.57973 15

protein binding

intracellular

cytoplasm

protein complex assembly

activation of NF-kappaB-inducing kinase activity

receptor signaling complex scaffold activity

CBM complex

regulation of apoptosis

 
1569033_at -0.233 4.240 -2.484 2.509e-02 0.513 -3.332 IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 7 -23316352 BC019258 7p11 Hs.700696 37

nucleotide binding

RNA binding

nucleus

cytoplasm

anatomical structure morphogenesis

negative regulation of translation

regulation of cytokine biosynthetic process

translation regulator activity

mRNA 5'-UTR binding

 
209914_s_at NRXN1 neurexin 1 2 -49999147, -49999147 AW149405 2p16.3 Hs.637685 36

receptor activity

calcium ion binding

protein binding

protein binding

integral to plasma membrane

cell adhesion

axon guidance

membrane

integral to membrane

Cell adhesion molecules (CAMs)

206567_s_at PHF20 PHD finger protein 20 20 33823336 NM_016436 20q11.22-q11.23 Hs.517044 11

DNA binding

protein binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
211058_x_at 0.575 10.584 2.715 1.581e-02 0.459 -2.944 TUBA1B tubulin, alpha 1b 12 -47807832 BC006379 12q13.12 Hs.524390 Hs.719075 42

nucleotide binding

microtubule cytoskeleton organization

GTPase activity

structural constituent of cytoskeleton

protein binding

GTP binding

microtubule

microtubule-based movement

protein complex

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

226285_at CAPRIN1 cell cycle associated protein 1 11 34029805, 34029805 AI808634 11p13 Hs.471818 10

protein binding

cytoplasm

cytosol

integral to plasma membrane

dendrite

cell projection

 
206723_s_at LPAR2 lysophosphatidic acid receptor 2 19 -19595465 AF011466 19p12 Hs.122575 34

activation of MAPK activity

lysosphingolipid and lysophosphatidic acid receptor activity

receptor activity

G-protein coupled receptor activity

protein binding

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

activation of phospholipase C activity

elevation of cytosolic calcium ion concentration

lipid binding

PDZ domain binding

LIM domain binding

positive regulation of Rho protein signal transduction

positive regulation of MAPKKK cascade

Neuroactive ligand-receptor interaction

218210_at FN3KRP fructosamine 3 kinase related protein 17 78267870 NM_024619 17q25.3 Hs.31431 12

kinase activity

transferase activity

 
211125_x_at GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 9 139153429 AF015730 9q34.3 Hs.558334 119

magnesium ion binding

receptor activity

N-methyl-D-aspartate selective glutamate receptor activity

ion channel activity

extracellular-glutamate-gated ion channel activity

calcium channel activity

calcium ion binding

calmodulin binding

plasma membrane

integral to plasma membrane

cation transport

synaptic transmission

synaptic vesicle

visual learning

postsynaptic density

glycine binding

glycine binding

glutamate binding

N-methyl-D-aspartate selective glutamate receptor complex

synaptosome

cell junction

dendrite

ionotropic glutamate receptor signaling pathway

glutamate receptor binding

regulation of membrane potential

synapse

postsynaptic membrane

response to ethanol

positive regulation of transcription from RNA polymerase II promoter

calcium ion homeostasis

regulation of excitatory postsynaptic membrane potential

Calcium signaling pathway

Neuroactive ligand-receptor interaction

Long-term potentiation

Alzheimer's disease

Amyotrophic lateral sclerosis (ALS)

Huntington's disease

1562403_a_at SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 14 -69580686, -69580686, -69580686 AK096553 14q24.1 Hs.337696 16

calcium:sodium antiporter activity

calcium ion binding

calmodulin binding

ion transport

sodium ion transport

calcium ion transport

cell communication

antiporter activity

membrane

integral to membrane

sodium ion binding

Calcium signaling pathway

227366_at RILP Rab interacting lysosomal protein 17 -1496194 AI084782 17p13.3 Hs.534497 20

lysosomal membrane

protein transport

membrane

Rab GTPase binding

phagocytic vesicle membrane

cytoplasmic vesicle

late endosome membrane

 
225073_at PPHLN1 periphilin 1 12 41006213, 41006213, 41006213, 41006213 NM_016488 12q12 Hs.444157 13

nucleus

cytoplasm

keratinization

 
219341_at 0.496 5.041 3.814 1.656e-03 0.263 -1.027 CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) 8 1699276 NM_018941 8p23 Hs.127675 15

age-dependent response to oxidative stress

endoplasmic reticulum

ER-Golgi intermediate compartment

phospholipid metabolic process

lipid transport

mitochondrial membrane organization

lysosome organization

nervous system development

adult walking behavior

cholesterol metabolic process

associative learning

regulation of cell size

lipid biosynthetic process

membrane

integral to membrane

spinal cord motor neuron differentiation

social behavior

negative regulation of apoptosis

cellular protein catabolic process

cellular macromolecule catabolic process

photoreceptor cell maintenance

negative regulation of proteolysis

ceramide biosynthetic process

musculoskeletal movement

neuromuscular process controlling posture

neuromuscular process controlling balance

negative regulation of transferase activity

glutamate uptake during transmission of nerve impulse

retina development in camera-type eye

neurofilament cytoskeleton organization

 
205270_s_at LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 5 -169607665 NM_005565 5q33.1-qter Hs.304475 72

protein binding

cytoplasm

cytosol

immune response

transmembrane receptor protein tyrosine kinase signaling pathway

mast cell activation

cytokine secretion

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

Fc epsilon RI signaling pathway

212280_x_at 0.254 6.641 2.285 3.708e-02 0.562 -3.657 ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) 2 242225699, 54821 AA532726 2q37.3 Hs.283610 19

protein binding

cytoplasm

microtubule associated complex

proteolysis

autophagy

peptidase activity

cysteine-type peptidase activity

protein transport

modification-dependent protein catabolic process

Regulation of autophagy

220793_at SAGE1 sarcoma antigen 1 X 134803450 NM_018666 Xq26 Hs.195292 4    
232464_at TRIMP1 tripartite motif-containing pseudogene 1 11 5620987 AF230412 11p15 Hs.709401 1    
212367_at FEM1B fem-1 homolog b (C. elegans) 15 66357194 AI799061 15q22 Hs.362733 9

ubiquitin-protein ligase activity

death receptor binding

death receptor binding

cellular_component

cytoplasm

induction of apoptosis

modification-dependent protein catabolic process

regulation of apoptosis

regulation of ubiquitin-protein ligase activity

 
1556262_at -0.384 5.895 -3.377 4.078e-03 0.323 -1.793 PWRN1 Prader-Willi region non-protein coding RNA 1 15 22354396 AK058147 15q11.2 Hs.456065 2    
202558_s_at 0.375 4.897 2.863 1.171e-02 0.426 -2.690 HSPA13 heat shock protein 70kDa family, member 13 21 -14665307 NM_006948 21q11 21q11.1 Hs.352341 16

nucleotide binding

ATP binding

endoplasmic reticulum

microsome

 
208753_s_at NAP1L1 nucleosome assembly protein 1-like 1 12 -74724938 BC002387 12q21.2 Hs.524599 Hs.695185 17

protein binding

nucleus

chromatin assembly complex

DNA replication

nucleosome assembly

positive regulation of cell proliferation

melanosome

 
1558186_s_at 0.382 2.952 3.432 3.645e-03 0.314 -1.698 CLLU1 chronic lymphocytic leukemia up-regulated 1 12 91339437, 91341865 BC014496 12q22 Hs.339918 5    
218534_s_at AGGF1 angiogenic factor with G patch and FHA domains 1 5 76361987 NM_018046 5q13.3 Hs.634849 12

vasculogenesis

positive regulation of endothelial cell proliferation

nucleic acid binding

protein binding

extracellular region

intracellular

cytoplasm

RNA processing

cell adhesion

multicellular organismal development

eukaryotic cell surface binding

positive regulation of angiogenesis

perinuclear region of cytoplasm

 
1568746_a_at hCG_1654703 hCG1654703 1   BC029599 1q23.1 Hs.506902 1    
217473_x_at SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 2 218954995 AF229163 2q35 Hs.591607 106

transporter activity

iron ion binding

vacuole

plasma membrane

integral to plasma membrane

ion transport

iron ion transport

cellular cadmium ion homeostasis

cellular iron ion homeostasis

response to bacterium

phagocytic vesicle membrane

protein homodimerization activity

transition metal ion transmembrane transporter activity

metal ion:hydrogen antiporter activity

cadmium ion transmembrane transport

Lysosome

202931_x_at BIN1 bridging integrator 1 2 -127522077, -127522076 NM_004305 2q14 Hs.193163 69

protein binding

nucleus

cytoplasm

multicellular organismal development

cell proliferation

actin cytoskeleton

regulation of endocytosis

cell differentiation

interspecies interaction between organisms

 
212380_at FTSJD2 FtsJ methyltransferase domain containing 2 6 37508884 D43949 6p21.2 Hs.520102 7

nucleic acid binding

protein binding

intracellular

methyltransferase activity

transferase activity

methylation

 
220238_s_at 0.275 3.260 2.270 3.814e-02 0.565 -3.681 KLHL7 kelch-like 7 (Drosophila) 7 23111877 NM_018846 7p15.3 Hs.654817 9

protein binding

nucleus

nucleolus

 
214073_at CTTN cortactin 11 69922259, 69922291 BG475299 11q13 Hs.596164 106

ruffle

protein binding

soluble fraction

cytoplasm

cytoskeleton

cell cortex

lamellipodium

Tight junction

Pathogenic Escherichia coli infection - EHEC

210513_s_at -0.325 6.267 -2.141 4.889e-02 0.590 -3.885 VEGFA vascular endothelial growth factor A 6 43845930 AF091352 6p12 Hs.73793 1447

angiogenesis

vasculogenesis

response to hypoxia

positive regulation of endothelial cell proliferation

positive regulation of endothelial cell proliferation

fibronectin binding

positive regulation of leukocyte migration

cytokine activity

platelet-derived growth factor receptor binding

extracellular region

extracellular region

proteinaceous extracellular matrix

extracellular space

multicellular organismal development

nervous system development

growth factor activity

heparin binding

regulation of cell shape

cell surface

membrane

positive regulation of vascular endothelial growth factor receptor signaling pathway

platelet alpha granule lumen

protein homodimerization activity

negative regulation of apoptosis

vascular endothelial growth factor receptor 1 binding

vascular endothelial growth factor receptor 2 binding

cell surface binding

positive regulation of blood vessel endothelial cell migration

platelet-derived growth factor receptor signaling pathway

extracellular matrix binding

induction of positive chemotaxis

Cytokine-cytokine receptor interaction

mTOR signaling pathway

VEGF signaling pathway

Focal adhesion

Pathways in cancer

Renal cell carcinoma

Pancreatic cancer

Bladder cancer

226120_at TTC8 tetratricopeptide repeat domain 8 14 88360730 AW293939 14q31.3 Hs.303055 7

binding

cytoplasm

centrosome

plasma membrane

cilium

visual perception

cell projection organization

BBSome

response to stimulus

cilium membrane

 
208696_at 0.353 8.894 2.564 2.143e-02 0.497 -3.200 CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 5 10303281 AF275798 5p15.2 Hs.1600 30

nucleotide binding

ATP binding

nucleus

nucleolus

cytoplasm

chaperonin-containing T-complex

protein folding

unfolded protein binding

 
205072_s_at XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 5 82409072 NM_022406 5q13-q14 Hs.567359 93

condensed chromosome

in utero embryonic development

pro-B cell differentiation

DNA binding

nucleus

nucleus

cytosol

DNA-dependent protein kinase-DNA ligase 4 complex

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

response to DNA damage stimulus

central nervous system development

protein C-terminus binding

response to X-ray

response to gamma radiation

ligase activity

provirus integration

initiation of viral infection

DNA ligase IV complex

T cell differentiation in the thymus

immunoglobulin V(D)J recombination

negative regulation of neuron apoptosis

isotype switching

positive regulation of fibroblast proliferation

positive regulation of neurogenesis

DNA ligation during DNA repair

positive regulation of ligase activity

Non-homologous end-joining

220044_x_at LUC7L3 LUC7-like 3 (S. cerevisiae) 17 46151975 NM_016424 17q21.33 Hs.130293 15

DNA binding

mRNA binding

protein binding

nucleus

mRNA processing

apoptosis

response to stress

RNA splicing

nuclear speck

 
228698_at SOX7 SRY (sex determining region Y)-box 7 8 -10618687 AI808807 8p22 Hs.709543 11

transcription factor activity

nucleus

regulation of transcription from RNA polymerase II promoter

regulation of transcription

 
235492_at 0.311 5.412 2.257 3.909e-02 0.567 -3.701 RNF217 ring finger protein 217 6 125346212 AI888256 6q22.31 Hs.368639 5

ubiquitin-protein ligase activity

protein binding

zinc ion binding

membrane

integral to membrane

ligase activity

modification-dependent protein catabolic process

protein ubiquitination during ubiquitin-dependent protein catabolic process

metal ion binding

 
1559901_s_at 0.411 4.715 3.152 6.487e-03 0.364 -2.188 C21orf34 chromosome 21 open reading frame 34 21 16364712, 16488569 BM194465 21q21.1 Hs.719301 5    
219297_at WDR44 WD repeat domain 44 X 117364069 NM_019045 Xq24 Hs.98510 16

cytoplasm

endosome

Golgi apparatus

cytosol

endosome membrane

membrane

perinuclear region of cytoplasm

 
228368_at ARHGAP20 Rho GTPase activating protein 20 11 -109952975 AI936560 11q23.1 Hs.6136 7

GTPase activator activity

intracellular

signal transduction

 
202724_s_at 0.644 7.398 3.323 4.561e-03 0.332 -1.888 FOXO1 forkhead box O1 13 -40027800 NM_002015 13q14.1 Hs.370666 140

blood vessel development

transcription factor activity

protein binding

nucleus

cytoplasm

regulation of transcription, DNA-dependent

anti-apoptosis

insulin receptor signaling pathway

transcription activator activity

regulation of cell proliferation

sequence-specific DNA binding

positive regulation of transcription from RNA polymerase II promoter

Insulin signaling pathway

Pathways in cancer

Prostate cancer

213789_at -0.223 5.459 -2.314 3.505e-02 0.555 -3.611 EBP emopamil binding protein (sterol isomerase) X 48265107 N58493 Xp11.23-p11.22 Hs.30619 19

C-8 sterol isomerase activity

skeletal system development

steroid delta-isomerase activity

transmembrane receptor activity

endoplasmic reticulum

microsome

integral to plasma membrane

cholesterol biosynthetic process

drug transporter activity

membrane

isomerase activity

hemopoiesis

cholestenol delta-isomerase activity

Steroid biosynthesis

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

222498_at 0.283 6.641 2.282 3.730e-02 0.562 -3.662 AZI2 5-azacytidine induced 2 3 -28348183, -28338850 AI809206 3p24.1 Hs.706676 12

cytoplasm

RIG-I-like receptor signaling pathway

207055_at GPR37L1 G protein-coupled receptor 37 like 1 1 200358651 NM_004767 1q32.1 Hs.132049 5

receptor activity

G-protein coupled receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

biological_process

integral to membrane

 
224744_at IMPAD1 inositol monophosphatase domain containing 1 8 -58033041 AW628838 8q12.1 Hs.716471 4

magnesium ion binding

inositol-1(or 4)-monophosphatase activity

membrane

integral to membrane

hydrolase activity

 
202950_at CRYZ crystallin, zeta (quinone reductase) 1 -74943762, -74943759 NM_001889 1p31-p22 Hs.83114 14

NADPH:quinone reductase activity

binding

cytoplasm

visual perception

zinc ion binding

oxidoreductase activity

oxidation reduction

 
222743_s_at 0.374 7.073 3.727 1.979e-03 0.273 -1.178 C11orf71 chromosome 11 open reading frame 71 11 -113767379 AV721563 11q14.2-q14.3 Hs.715083 3    
207864_at SCN7A sodium channel, voltage-gated, type VII, alpha 2 -166969784 NM_002976 2q21-q23 Hs.695947 11

voltage-gated sodium channel complex

voltage-gated ion channel activity

voltage-gated sodium channel activity

ion transport

sodium ion transport

muscle contraction

membrane

integral to membrane

sodium ion binding

 
202313_at PPP2R2A protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform 8 26204950 NM_002717 8p21.2 Hs.146339 44

protein phosphatase type 2A complex

protein serine/threonine phosphatase activity

protein binding

protein amino acid dephosphorylation

signal transduction

protein phosphatase type 2A regulator activity

response to morphine

Tight junction

228358_at SOX12 SRY (sex determining region Y)-box 12 20 254238 AI161357 20p13 Hs.43627 Hs.712815 9

DNA binding

RNA polymerase II transcription factor activity

nucleus

regulation of transcription from RNA polymerase II promoter

regulation of transcription

 
217892_s_at LIMA1 LIM domain and actin binding 1 12 -48855829, -48855829 NM_016357 12q13 Hs.525419 23

stress fiber

actin monomer binding

cytoplasm

focal adhesion

zinc ion binding

actin cytoskeleton

cell junction

negative regulation of actin filament depolymerization

ruffle organization

metal ion binding

actin filament binding

actin filament bundle formation

 
220554_at SLC22A7 solute carrier family 22 (organic anion transporter), member 7 6 43373975 NM_006672 6p21.2-p21.1 Hs.485438 10

membrane fraction

plasma membrane

integral to plasma membrane

ion transport

ion transmembrane transporter activity

sodium-independent organic anion transmembrane transporter activity

organic anion transport

 
1554500_a_at RGS7 regulator of G-protein signaling 7 1 -239005439 AF493931 1q23.1 1q43 Hs.655739 23

signal transducer activity

protein binding

cellular_component

heterotrimeric G-protein complex

intracellular signaling cascade

regulation of G-protein coupled receptor protein signaling pathway

negative regulation of signal transduction

 
218859_s_at ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 20 -13642968 NM_016649 20p12.1 Hs.369284 10

nucleus

nucleoplasm

nucleolus

regulation of transcription

 
228024_at VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 8 17148771 AW028100 8p22 Hs.343873 Hs.512464 8

nucleus

endosome

protein transport

membrane

Endocytosis

226581_at ZFYVE20 zinc finger, FYVE domain containing 20 3 -15086583 AA524034 3p25.1 Hs.475565 Hs.706478 9

intracellular

endosome

plasma membrane

zinc ion binding

protein transport

endosome transport

metal ion binding

Endocytosis

1555704_at -0.273 3.831 -2.305 3.569e-02 0.556 -3.626 CMTM3 CKLF-like MARVEL transmembrane domain containing 3 16 65195702, 65195713, 65196067 AY166714 16q21 Hs.298198 7

cytokine activity

extracellular space

chemotaxis

membrane

integral to membrane

 
210818_s_at -0.214 2.702 -2.628 1.886e-02 0.488 -3.093 BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 21 29593090, 29593607, 29599430 AF026199 21q22.11 Hs.154276 30

transcription factor activity

nucleus

nucleolus

cytosol

regulation of transcription, DNA-dependent

sequence-specific DNA binding

protein dimerization activity

 
214764_at RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) 1 216525251 AW029169 1q41 Hs.660109 8

protein binding

 
242844_at 0.333 5.604 2.276 3.771e-02 0.564 -3.672 PGGT1B protein geranylgeranyltransferase type I, beta subunit 5 -114574425 AA989220 5q22.3 Hs.254006 8

prenyltransferase activity

CAAX-protein geranylgeranyltransferase activity

CAAX-protein geranylgeranyltransferase complex

zinc ion binding

transferase activity

protein amino acid geranylgeranylation

metal ion binding

 
227371_at BAIAP2L1 BAI1-associated protein 2-like 1 7 -97758903 AA496034 7q21.3-q22.1 Hs.656063 Hs.710371 13

molecular_function

actin binding

cellular_component

signal transduction

cytoskeletal adaptor activity

biological_process

SH3 domain binding

filopodium assembly

 
229959_at KLKB1 kallikrein B, plasma (Fletcher factor) 1 4 187385665 BE670622 4q34-q35 Hs.237642 46

Factor XII activation

serine-type endopeptidase activity

extracellular region

extracellular space

cytoplasm

proteolysis

inflammatory response

blood coagulation

peptidase activity

plasminogen activation

positive regulation of fibrinolysis

Complement and coagulation cascades

227689_at 0.749 4.749 3.872 1.469e-03 0.250 -0.926 ZNF227 zinc finger protein 227 19 49408530 BF739795   Hs.371335 6

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
1569737_a_at CASKIN1 CASK interacting protein 1 16 -2167184 BC042011 16p13.3 Hs.643537 3

protein binding

cytoplasm

signal transduction

 
203652_at -0.204 6.164 -2.209 4.295e-02 0.576 -3.779 MAP3K11 mitogen-activated protein kinase kinase kinase 11 11 -65121801 NM_002419 11q13.1-q13.3 Hs.502872 44

G1 phase of mitotic cell cycle

nucleotide binding

protein serine/threonine kinase activity

JUN kinase kinase kinase activity

protein tyrosine kinase activity

protein binding

ATP binding

centrosome

microtubule

microtubule-based process

activation of JUN kinase activity

cell proliferation

transferase activity

protein homodimerization activity

regulation of JNK cascade

protein amino acid autophosphorylation

protein oligomerization

MAPK signaling pathway

203523_at LSP1 lymphocyte-specific protein 1 11 1830775, 1846478, 1848674, 1848729 NM_002339 11p15.5 Hs.56729 30

actin binding

signal transducer activity

plasma membrane

cell motion

cellular defense response

signal transduction

actin cytoskeleton

 
203303_at 0.455 7.416 2.613 1.942e-02 0.489 -3.117 DYNLT3 dynein, light chain, Tctex-type 3 X -37583033 NM_006520 Xp21 Hs.446392 13

molecular_function

motor activity

protein binding

cellular_component

microtubule

biological_process

dynein complex

 
201712_s_at RANBP2 RAN binding protein 2 2 108702368 NM_006267 2q12.3 Hs.199561 Hs.715056 61

peptidyl-prolyl cis-trans isomerase activity

protein binding

intracellular

nucleus

nuclear pore

cytosol

protein folding

protein import into nucleus

zinc ion binding

Ran GTPase binding

protein transport

isomerase activity

modification-dependent protein catabolic process

metal ion binding

intracellular transport

mRNA transport

intracellular protein transmembrane transport

 
211043_s_at CLTB clathrin, light chain (Lcb) 5 -175752061 BC006332 4q2-q3 5q35 Hs.484241 17

structural molecule activity

calcium ion binding

protein binding

intracellular protein transport

membrane

vesicle-mediated transport

clathrin coat of trans-Golgi network vesicle

clathrin coat of coated pit

cytoplasmic vesicle

Lysosome

Endocytosis

Huntington's disease

240396_at IL20RA interleukin 20 receptor, alpha 6 -137362800 AI686661 6q22.33-q23.1 Hs.445868 15

receptor activity

cytokine receptor activity

membrane

integral to membrane

Cytokine-cytokine receptor interaction

Jak-STAT signaling pathway

211982_x_at XPO6 exportin 6 16 -28016816 AL546600 16p11.2 Hs.460468 11

protein import into nucleus, docking

protein binding

nucleus

nuclear pore

cytoplasm

protein export from nucleus

intracellular protein transport

protein transporter activity

 
214464_at 0.532 7.215 2.811 1.304e-02 0.433 -2.781 CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 1 -225244188 NM_003607 1q42.11 Hs.35433 20

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

small GTPase regulator activity

ATP binding

cytoplasm

cell-cell junction

protein amino acid phosphorylation

intracellular signaling cascade

zinc ion binding

transferase activity

diacylglycerol binding

cell leading edge

actin cytoskeleton reorganization

identical protein binding

 
205073_at CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 1 -60131567 NM_000775 1p31.3-p31.2 Hs.152096 50

endoplasmic reticulum

microsome

fatty acid metabolic process

icosanoid metabolic process

regulation of heart contraction

arachidonic acid epoxygenase activity

electron carrier activity

membrane

heme binding

metal ion binding

oxidation reduction

aromatase activity

Arachidonic acid metabolism

Linoleic acid metabolism

Metabolic pathways

207489_at RPS2P45 ribosomal protein S2 pseudogene 45 16   NM_024986 16q22.1 Hs.661121 3    
210011_s_at 0.306 6.699 4.259 6.660e-04 0.211 -0.258 EWSR1 Ewing sarcoma breakpoint region 1 22 27993997, 27993997 BC000527 22q12.2 Hs.374477 90

nucleotide binding

RNA binding

calmodulin binding

intracellular

nucleus

cytoplasm

plasma membrane

zinc ion binding

regulation of transcription

metal ion binding

 
213067_at 0.613 4.812 2.721 1.562e-02 0.459 -2.934 MYH10 myosin, heavy chain 10, non-muscle 17 -8318254 AI382123 17p13 Hs.16355 37

microfilament motor activity

nucleotide binding

cytokinesis after mitosis

in utero embryonic development

stress fiber

neuron migration

plasma membrane repair

calmodulin binding

ATP binding

cytoplasm

spindle

plasma membrane

cell cortex

exocytosis

substrate-bound cell migration, cell extension

nuclear migration

axon guidance

brain development

adult heart development

biological_process

cell proliferation

regulation of cell shape

myosin complex

fourth ventricle development

lateral ventricle development

third ventricle development

cerebellar Purkinje cell layer development

actin cytoskeleton organization

actin filament-based movement

axon

growth cone

midbody

actin-dependent ATPase activity

neuron projection development

neuromuscular junction

cleavage furrow

cell soma

dendritic spine

ADP binding

neuromuscular process controlling balance

actin filament binding

cardiac myofibril assembly

ventricular cardiac muscle cell development

retina development in camera-type eye

Tight junction

Regulation of actin cytoskeleton

208058_s_at MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 22 38183270, 38213174 NM_002409 22q13.1 Hs.276808 17

beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

Golgi apparatus

protein amino acid N-linked glycosylation

membrane

integral to membrane

transferase activity, transferring glycosyl groups

N-Glycan biosynthesis

Metabolic pathways

223140_s_at 0.381 7.950 2.976 9.301e-03 0.401 -2.495 DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 3 -155476150 AF217190 3p13-q23 Hs.446270 13

nucleotide binding

nucleic acid binding

helicase activity

protein binding

ATP binding

nucleus

cytoplasm

ATP-dependent helicase activity

hydrolase activity

 
205032_at ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 5 52320912 NM_002203 5q23-q31 Hs.482077 235

magnesium ion binding

receptor activity

calcium ion binding

collagen binding

plasma membrane

plasma membrane

cell adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

blood coagulation

integrin complex

organ morphogenesis

external side of plasma membrane

integral to membrane

identical protein binding

interspecies interaction between organisms

Focal adhesion

ECM-receptor interaction

Hematopoietic cell lineage

Regulation of actin cytoskeleton

Pathways in cancer

Small cell lung cancer

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

225346_at 0.535 6.759 3.047 8.046e-03 0.386 -2.371 MTERFD3 MTERF domain containing 3 12 -105895198 NM_025198 12q24.1 Hs.5009 6

mitochondrion

transcription termination

regulation of transcription

 
232149_s_at 0.351 5.613 2.137 4.920e-02 0.590 -3.890 NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 8 -59658619, -59658619 BF056507 8q12-q13 Hs.372000 8

receptor signaling protein activity

soluble fraction

cytoplasm

ceramide metabolic process

signal transduction

 
220311_at 0.461 4.626 3.037 8.218e-03 0.387 -2.389 N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) 21 -29166383 NM_013240 21q21.3 Hs.163846 6

nucleic acid binding

protein binding

protein methyltransferase activity

transferase activity

positive regulation of cell growth

methylation

protein complex

 
202261_at VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 1 -149415557 NM_005997 1q21 Hs.2430 10

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

chromatin modification

protein complex

regulation of transcription

 
240282_at WDR1 WD repeat domain 1 4 -9685060 AW770902 4p16.1 Hs.128548 Hs.713658 15

actin binding

protein binding

cytoplasm

cytoskeleton

sensory perception of sound

 
202381_at 0.343 7.704 2.345 3.299e-02 0.550 -3.561 ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma) 8 38973661, 38973661 NM_003816 8p11.22 Hs.591852 36

activation of MAPKK activity

metalloendopeptidase activity

protein kinase C binding

integrin binding

integrin binding

integrin binding

collagen binding

extracellular region

extracellular space

cytoplasm

plasma membrane

proteolysis

response to oxidative stress

cell-matrix adhesion

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

peptidase activity

zinc ion binding

cell surface

response to manganese ion

integral to membrane

SH3 domain binding

SH3 domain binding

keratinocyte differentiation

intrinsic to external side of plasma membrane

positive regulation of cell adhesion mediated by integrin

cell-cell adhesion mediated by integrin

positive regulation of macrophage fusion

response to tumor necrosis factor

monocyte activation

response to hydrogen peroxide

laminin binding

metal ion binding

positive regulation of protein secretion

positive regulation of membrane protein ectodomain proteolysis

PMA-inducible membrane protein ectodomain proteolysis

response to glucocorticoid stimulus

positive regulation of keratinocyte migration

response to calcium ion

 
201860_s_at 0.366 5.248 2.434 2.771e-02 0.527 -3.415 PLAT plasminogen activator, tissue 8 -42151392 NM_000930 8p12 Hs.491582 209

serine-type endopeptidase activity

extracellular region

extracellular region

extracellular space

protein modification process

proteolysis

blood coagulation

peptidase activity

Complement and coagulation cascades

222975_s_at 0.325 10.872 2.156 4.752e-02 0.585 -3.862 CSDE1 cold shock domain containing E1, RNA-binding 1 -115061060, -115061060, -115061059 AI423180 1p22 Hs.69855 25

DNA binding

RNA binding

protein binding

cytoplasm

regulation of transcription, DNA-dependent

male gonad development

 
228716_at THRB thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) 3 -24133648, -24133648 BG494007 3p24.2 Hs.187861 130

double-stranded DNA binding

transcription factor activity

steroid hormone receptor activity

transcription corepressor activity

thyroid hormone receptor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

sensory perception of sound

regulation of heart contraction

zinc ion binding

organ morphogenesis

negative regulation of transcription

regulation of lipid metabolic process

positive regulation of chondrocyte differentiation

protein homodimerization activity

sequence-specific DNA binding

positive regulation of ossification

positive regulation of transcription from RNA polymerase II promoter

metal ion binding

Neuroactive ligand-receptor interaction

229238_at -0.860 5.077 -2.759 1.447e-02 0.447 -2.869 C17orf97 chromosome 17 open reading frame 97 17 260433 BE552331 17p13.3 Hs.499607 1    
238935_at RPS27L ribosomal protein S27-like 15 -61232591 AW958475 15q22.2 Hs.108957 6

structural constituent of ribosome

intracellular

nucleus

ribosome

DNA repair

translation

response to DNA damage stimulus

zinc ion binding

translation activator activity

caspase activator activity

G1 DNA damage checkpoint

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

positive regulation of anti-apoptosis

metal ion binding

 
236070_at -0.181 5.882 -2.573 2.103e-02 0.497 -3.184 C2orf81 chromosome 2 open reading frame 81 2 -74494810 AA720997 2p13.1 Hs.445377 1    
236225_at GGT6 gamma-glutamyltransferase 6 17 -4406970 AI697028 17p13.2 Hs.130749 5

gamma-glutamyltransferase activity

glutathione biosynthetic process

acyltransferase activity

membrane

integral to membrane

transferase activity

Taurine and hypotaurine metabolism

Selenoamino acid metabolism

Cyanoamino acid metabolism

Glutathione metabolism

Arachidonic acid metabolism

Metabolic pathways

207990_x_at -0.341 4.089 -2.919 1.045e-02 0.418 -2.593 ACRV1 acrosomal vesicle protein 1 11 -125047438 NM_020114 11q23-q24 Hs.169222 Hs.596575 12

acrosomal vesicle

multicellular organismal development

 
219355_at CXorf57 chromosome X open reading frame 57 X 105741815 NM_018015 Xq22.3 Hs.274267 5    
201306_s_at 0.420 9.127 2.627 1.890e-02 0.488 -3.094 ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 9 99785309 NM_006401 9q22.32 Hs.715547 16

protein binding

nucleus

 
225162_at SH3D19 SH3 domain containing 19 4 -152260882, -152260882 BG285417 4q31.3 Hs.567725 12

nucleus

nucleolus

cytoplasm

Golgi apparatus

plasma membrane

positive regulation of membrane protein ectodomain proteolysis

 
220664_at SPRR2C small proline-rich protein 2C (pseudogene) 1 -151379217 NM_006518 1q21-q22 Hs.2421 5    
225378_at 0.487 6.877 2.160 4.710e-02 0.584 -3.855 VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 8 17148771 AI866426 8p22 Hs.343873 Hs.512464 8

nucleus

endosome

protein transport

membrane

Endocytosis

205246_at PEX13 peroxisomal biogenesis factor 13 2 61098315 NM_002618 2p14-p16 Hs.161377 21

fatty acid alpha-oxidation

neuron migration

suckling behavior

protein binding

membrane fraction

peroxisome

peroxisomal membrane

integral to peroxisomal membrane

locomotory behavior

protein transport

membrane

integral to membrane

protein import into peroxisome matrix, docking

protein import into peroxisome matrix, docking

cerebral cortex cell migration

microtubule-based peroxisome localization

 
206021_at -0.283 4.693 -2.140 4.892e-02 0.590 -3.886 SCAND2 SCAN domain containing 2 pseudogene 15 82975694 NM_022050 15q25-q26 Hs.658114 7

molecular_function

transcription factor activity

cellular_component

nucleus

regulation of transcription, DNA-dependent

biological_process

 
221665_s_at EPS8L1 EPS8-like 1 19 60279032, 60283571 BC004907 19q13.42 Hs.438862 8

molecular_function

cellular_component

cytoplasm

biological_process

 
1570173_at INTS7 integrator complex subunit 7 1 -210181320 BC036009 1p36.13-q42.3 Hs.369285 8

protein binding

nucleus

snRNA processing

integrator complex

 
207657_x_at 0.276 8.286 2.628 1.885e-02 0.488 -3.092 TNPO1 transportin 1 5 72148173, 72179685 NM_002270 5q13.2 Hs.482497 58

protein import into nucleus, docking

protein import into nucleus, translocation

protein binding

nucleus

nuclear pore

cytoplasm

nuclear localization sequence binding

protein transporter activity

interspecies interaction between organisms

 
226221_at KIAA1432 KIAA1432 9 5619326, 5646582 AL138104 9p24.1 Hs.211520 5

membrane

integral to membrane

 
203261_at 0.289 8.809 3.288 4.899e-03 0.341 -1.949 DCTN6 dynactin 6 8 30133354 NM_006571 8p12-p11 Hs.146585 6

cytoplasm

cytoskeleton

dynactin complex

transferase activity

dynein binding

 
211489_at ADRA1A adrenergic, alpha-1A-, receptor 8 -26683138, -26679287, -26669829, -26661583 D32201 8p21-p11.2 Hs.709175 67

receptor activity

G-protein coupled receptor activity

adrenoceptor activity

alpha1-adrenergic receptor activity

alpha1-adrenergic receptor activity

plasma membrane

integral to plasma membrane

apoptosis

smooth muscle contraction

signal transduction

G-protein coupled receptor protein signaling pathway

protein kinase cascade

cell-cell signaling

negative regulation of cell proliferation

Calcium signaling pathway

Neuroactive ligand-receptor interaction

Vascular smooth muscle contraction

222855_s_at -0.313 4.377 -2.851 1.202e-02 0.426 -2.712 TRPV2 transient receptor potential cation channel, subfamily V, member 2 17 16259612 BF058747 17p11.2 Hs.279746 18

calcium channel activity

calcium ion binding

intracellular

cytoplasm

plasma membrane

integral to plasma membrane

ion transport

calcium ion transport

sensory perception

response to temperature stimulus

melanosome

 
1561908_a_at HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 17 14145230 AL832823 17p12-p11.2 Hs.48384 10

Golgi apparatus

integral to plasma membrane

sulfotransferase activity

[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

membrane

transferase activity

[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity

Glycosaminoglycan degradation

Heparan sulfate biosynthesis

200969_at 0.437 6.095 2.883 1.125e-02 0.426 -2.656 SERP1 stress-associated endoplasmic reticulum protein 1 3 -151742469 BG107676 3q25.1 Hs.518326 Hs.709270 10

skeletal system development

endoplasmic reticulum

ribosome

glucose metabolic process

protein amino acid glycosylation

response to stress

plasma membrane organization

post-embryonic development

multicellular organismal aging

protein transport

membrane

integral to membrane

endoplasmic reticulum unfolded protein response

positive regulation of insulin secretion

positive regulation of translation

positive regulation of organ growth

muscle organ morphogenesis

positive regulation of growth hormone secretion

intracellular protein transmembrane transport

 
1568680_s_at YTHDC2 YTH domain containing 2 5 112877308 BC019100 5q22.2 Hs.231942 6

nucleotide binding

nucleic acid binding

helicase activity

ATP binding

hydrolase activity

 
209250_at 0.472 7.134 3.596 2.596e-03 0.287 -1.409 DEGS1 degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) 1 222437550 BC000961 1q42.11 Hs.299878 5

protein binding

membrane fraction

endoplasmic reticulum

integral to plasma membrane

unsaturated fatty acid biosynthetic process

electron carrier activity

membrane

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

oxidation reduction

Sphingolipid metabolism

Metabolic pathways

213146_at -0.254 4.838 -2.281 3.738e-02 0.562 -3.664 KDM6B lysine (K)-specific demethylase 6B 17 7683959 AA521267 17p13.1 Hs.223678 8

negative regulation of transcription from RNA polymerase II promoter

binding

iron ion binding

nucleus

inflammatory response

oxidoreductase activity

chromatin modification

histone demethylation

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

sequence-specific DNA binding

metal ion binding

oxidation reduction

 
219029_at 0.443 4.733 2.198 4.382e-02 0.578 -3.795 C5orf28 chromosome 5 open reading frame 28 5 -43480110 NM_022483 5p12 Hs.558531 5

membrane

integral to membrane

 
207309_at NOS1 nitric oxide synthase 1 (neuronal) 12 -116135361 NM_000620 12q24.2-q24.31 Hs.654410 188

response to hypoxia

photoreceptor inner segment

nitric-oxide synthase activity

calmodulin binding

cytoplasm

cytoskeleton

arginine catabolic process

nitric oxide biosynthetic process

myoblast fusion

electron carrier activity

response to heat

FMN binding

negative regulation of calcium ion transport into cytosol

oxidoreductase activity

sarcoplasmic reticulum

heme binding

multicellular organismal response to stress

tetrahydrobiopterin binding

arginine binding

neurotransmitter biosynthetic process

sarcolemma

cell projection

dendritic spine

positive regulation of vasodilation

positive regulation of vasodilation

cadmium ion binding

metal ion binding

perinuclear region of cytoplasm

FAD binding

NADP or NADPH binding

oxidation reduction

regulation of cardiac muscle contraction

Arginine and proline metabolism

Metabolic pathways

Calcium signaling pathway

Long-term depression

Alzheimer's disease

Amyotrophic lateral sclerosis (ALS)

Pathways in cancer

Small cell lung cancer

203841_x_at 0.375 4.718 2.722 1.559e-02 0.459 -2.932 MAPRE3 microtubule-associated protein, RP/EB family, member 3 2 27047028 BG222594 2p23.3-p23.1 Hs.515860 13

small GTPase regulator activity

cytoplasm

microtubule

cell cycle

mitosis

microtubule binding

midbody

positive regulation of gene-specific transcription

cell division

 
213899_at METAP2 methionyl aminopeptidase 2 12 94391952 AI743685 12q22 Hs.444986 35

aminopeptidase activity

cytoplasm

proteolysis

peptidase activity

metalloexopeptidase activity

cellular process

protein processing

peptidyl-methionine modification

N-terminal protein amino acid modification

metal ion binding

cobalt ion binding

 
224694_at 0.860 7.193 3.428 3.674e-03 0.314 -1.704 ANTXR1 anthrax toxin receptor 1 2 69093779, 69093779, 69093779 AF279145 2p13.1 Hs.165859 24

transmembrane receptor activity

collagen binding

membrane

integral to membrane

lamellipodium membrane

filopodium membrane

actin cytoskeleton reorganization

substrate adhesion-dependent cell spreading

metal ion binding

actin filament binding

 
237536_at LOC100128977 hypothetical LOC100128977 17 -41276503 AW450849 17q21.31 Hs.666302 2    
244084_at AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 22 19649417, 19651446 AA468769 22q11.21 Hs.163543 9

iron ion binding

nucleus

cytoplasm

mitochondrion

mitochondrial inner membrane

endoplasmic reticulum

cytosol

plasma membrane

transport

apoptosis

induction of apoptosis

activation of caspase activity by cytochrome c

caspase activator activity

electron carrier activity

oxidoreductase activity

electron transport chain

cell redox homeostasis

metal ion binding

FAD binding

2 iron, 2 sulfur cluster binding

mitochondrial depolarization

 
228263_at GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 12 50687014 AI190755 12q13.13 Hs.407202 7

protein binding

cytoplasm

plasma membrane

signal transduction

cell junction

synapse

postsynaptic membrane

perinuclear region of cytoplasm

 
1556960_a_at hCG_2007354 hCG2007354 12   AK057223 12q24.33 Hs.703008 2    
224822_at DLC1 deleted in liver cancer 1 8 -13116452, -12985242, -12985242 AA524250 8p22 Hs.134296 48

neural tube closure

heart morphogenesis

GTPase activator activity

protein binding

intracellular

nucleus

cytoplasm

caveola

focal adhesion

induction of apoptosis

activation of caspase activity

signal transduction

negative regulation of cell proliferation

negative regulation of cell proliferation

regulation of cell shape

hindbrain morphogenesis

negative regulation of cell migration

negative regulation of cell migration

Rac GTPase activator activity

forebrain development

regulation of actin cytoskeleton organization

negative regulation of Rho protein signal transduction

positive regulation of protein amino acid dephosphorylation

SH2 domain binding

focal adhesion formation

negative regulation of stress fiber formation

 
204127_at RFC3 replication factor C (activator 1) 3, 38kDa 13 33290205, 33290205 BC000149 13q12.3-q13 Hs.115474 29

nucleotide binding

DNA synthesis during DNA repair

DNA clamp loader activity

protein binding

nucleus

nucleoplasm

DNA replication factor C complex

DNA replication factor C complex

DNA strand elongation during DNA replication

nucleotide-excision repair, DNA gap filling

ATPase activity

response to organophosphorus

DNA replication

Nucleotide excision repair

Mismatch repair

228801_at ORMDL1 ORM1-like 1 (S. cerevisiae) 2 -190343237 AI809749 2q32 Hs.709387 7

endoplasmic reticulum

endoplasmic reticulum membrane

membrane

integral to membrane

 
212260_at GIGYF2 GRB10 interacting GYF protein 2 2 233270258 AL045800 2q37.1 Hs.565319 23

protein binding

 
230686_s_at SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 20 -44619869, -44619869 AI634662 20q12-q13.1 Hs.655498 12

transporter activity

centrosome

plasma membrane

ion transport

sodium ion transport

symporter activity

integral to membrane

cell junction

sodium ion binding

 
223600_s_at KIAA1683 KIAA1683 19 -18228906 AL136867 19p13.1 Hs.313471 12

mitochondrion

 
209400_at SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4 16 -66534877, -66534877, -66534877 U55054 16q22.1 Hs.10094 16

transporter activity

membrane fraction

integral to plasma membrane

ion transport

potassium ion transport

sodium ion transport

chloride transport

cell volume homeostasis

symporter activity

potassium:chloride symporter activity

membrane

potassium ion binding

 
238231_at NFYC nuclear transcription factor Y, gamma 1 40929828, 40930266 AV700263 1p32 Hs.233458 Hs.713051 24

transcription factor activity

RNA polymerase II transcription factor activity

transcription coactivator activity

protein binding

intracellular

nucleus

regulation of transcription from RNA polymerase II promoter

protein folding

CCAAT-binding factor complex

sequence-specific DNA binding

Antigen processing and presentation

214285_at FABP3 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) 1 -31610686 AI041520 1p33-p32 Hs.657242 35

transporter activity

cytoplasm

phosphatidylcholine biosynthetic process

transport

negative regulation of cell proliferation

lipid binding

PPAR signaling pathway

225116_at HIPK2 homeodomain interacting protein kinase 2 7 -138896855 AW300045 7q32-q34 Hs.397465 Hs.632033 66

nucleotide binding

transcription corepressor activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

cytoplasm

centrosome

protein amino acid phosphorylation

apoptosis

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

induction of apoptosis by intracellular signals

PML body

transferase activity

virus-host interaction

positive regulation of transforming growth factor beta receptor signaling pathway

nuclear membrane

regulation of transcription

positive regulation of transcription, DNA-dependent

positive regulation of JNK cascade

virion binding

 
1553978_at 0.314 7.048 2.532 2.281e-02 0.503 -3.252 LOC729991 hypothetical protein LOC729991 19 -19153684, -19148713 BC010931 19p13.11 Hs.153629 6

protein binding

 
232631_at -0.330 4.685 -2.367 3.162e-02 0.544 -3.525 CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 5 31229552 AU150574 5p15.1-p14 Hs.171054 14

calcium ion binding

protein binding

nucleus

cytoplasm

plasma membrane

cell adhesion

homophilic cell adhesion

female gonad development

integral to membrane

 
205168_at DDR2 discoidin domain receptor tyrosine kinase 2 1 160868851 NM_006182 1q23.3 Hs.275757 Hs.593833 26

nucleotide binding

transmembrane receptor protein tyrosine kinase activity

receptor activity

ATP binding

integral to plasma membrane

protein amino acid phosphorylation

cell adhesion

signal transduction

transmembrane receptor protein tyrosine kinase signaling pathway

positive regulation of cell proliferation

membrane

transferase activity

 
203076_s_at 0.318 7.236 2.214 4.247e-02 0.575 -3.770 SMAD2 SMAD family member 2 18 -43613464, -43613463, -43613463 U65019 18q21.1 Hs.12253 Hs.705764 206

mesoderm formation

double-stranded DNA binding

transcription factor activity

intracellular

nucleus

nucleoplasm

cytoplasm

cytosol

SMAD protein complex assembly

intracellular signaling cascade

zygotic determination of dorsal/ventral axis

gastrulation

transcription factor binding

anterior/posterior pattern formation

positive regulation of epithelial to mesenchymal transition

promoter binding

transcription activator activity

regulation of transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

primary microRNA processing

ubiquitin protein ligase binding

activin responsive factor complex

type I transforming growth factor beta receptor binding

positive regulation of gene-specific transcription

cell fate commitment

negative regulation of transcription, DNA-dependent

positive regulation of transcription from RNA polymerase II promoter

paraxial mesoderm morphogenesis

regulation of binding

palate development

co-SMAD binding

R-SMAD binding

response to cholesterol

Cell cycle

Wnt signaling pathway

TGF-beta signaling pathway

Adherens junction

Pathways in cancer

Colorectal cancer

Pancreatic cancer

223519_at ZAK sterile alpha motif and leucine zipper containing kinase AZK 2 173648810, 173648810 AW069181 2q24.2 Hs.444451 24

cell cycle checkpoint

DNA damage checkpoint

nucleotide binding

activation of MAPKK activity

magnesium ion binding

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

protein tyrosine kinase activity

ATP binding

nucleus

cytoplasm

response to stress

cell cycle

cell cycle arrest

protein kinase cascade

activation of JUN kinase activity

cell death

cell proliferation

response to radiation

transferase activity

cell differentiation

identical protein binding

positive regulation of apoptosis

MAPK signaling pathway

Tight junction

209026_x_at 0.680 9.366 2.634 1.861e-02 0.486 -3.082 TUBB tubulin, beta 6 30796135, 2136731, 1935034 AF141349 6p21.33 Hs.636480 Hs.706187 Hs.714425 39

nucleotide binding

GTPase activity

structural constituent of cytoskeleton

GTP binding

cytoskeleton

microtubule

cell motion

microtubule-based movement

flotillin complex

natural killer cell mediated cytotoxicity

MHC class I protein binding

spindle assembly

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

216419_at CROCC ciliary rootlet coiled-coil, rootletin 1 17121031 AK026910 1pter-p36.11 Hs.309403 10

structural molecule activity

protein binding

centriole

cell cycle

protein localization

kinesin binding

cell projection organization

ciliary rootlet

centrosome organization

 
206899_at -0.462 4.901 -3.715 2.029e-03 0.273 -1.199 NTSR2 neurotensin receptor 2 2 -11715754 NM_012344 2p25.1 Hs.131138 14

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

sensory perception

neurotensin receptor activity, G-protein coupled

regulation of membrane potential

Neuroactive ligand-receptor interaction

230906_at 0.246 5.108 2.807 1.313e-02 0.433 -2.787 GALNT10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) 5 153550487, 153763529 AK024931 5q33.2 Hs.651323 Hs.655011 6

polypeptide N-acetylgalactosaminyltransferase activity

calcium ion binding

sugar binding

Golgi apparatus

protein amino acid O-linked glycosylation

membrane

integral to membrane

transferase activity, transferring glycosyl groups

manganese ion binding

O-Glycan biosynthesis

Metabolic pathways

228878_s_at CFC1B cripto, FRL-1, cryptic family 1B 2 -131066822, 130995136 BE550131 2q21.1 Hs.503733 1    
220358_at -0.216 5.589 -2.537 2.259e-02 0.501 -3.244 BATF3 basic leucine zipper transcription factor, ATF-like 3 1 -210926381 NM_018664 1q32.3 Hs.62919 7

transcription factor activity

transcription corepressor activity

nucleus

regulation of transcription, DNA-dependent

transcription from RNA polymerase II promoter

sequence-specific DNA binding

protein dimerization activity

 
1555562_a_at ZCCHC7 zinc finger, CCHC domain containing 7 9 37110468 BC022434 9p13.2 Hs.654700 6

nucleic acid binding

zinc ion binding

metal ion binding

RNA degradation

238711_s_at ZNF148 zinc finger protein 148 3 -126427202 AI669304 3q21 Hs.592591 34

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

specific RNA polymerase II transcription factor activity

intracellular

nucleus

DNA-directed RNA polymerase II, core complex

nucleolus

Golgi apparatus

cellular defense response

gamete generation

zinc ion binding

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

metal ion binding

 
212535_at 0.230 8.997 2.185 4.493e-02 0.581 -3.816 MEF2A myocyte enhancer factor 2A 15 97923655, 97990705 AA142929 15q26 Hs.268675 77

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

apoptosis

multicellular organismal development

nervous system development

muscle organ development

cell differentiation

sequence-specific DNA binding

 
207024_at 0.501 6.034 3.548 2.864e-03 0.297 -1.492 CHRND cholinergic receptor, nicotinic, delta 2 233099165 NM_000751 2q33-q34 Hs.156289 21

nicotinic acetylcholine-activated cation-selective channel activity

ion channel activity

extracellular ligand-gated ion channel activity

protein binding

plasma membrane

nicotinic acetylcholine-gated receptor-channel complex

ion transport

muscle contraction

signal transduction

integral to membrane

cell junction

neurotransmitter receptor activity

acetylcholine binding

regulation of membrane potential

synapse

postsynaptic membrane

skeletal muscle tissue growth

musculoskeletal movement

neuromuscular process

 
217766_s_at 0.451 6.749 2.742 1.497e-02 0.453 -2.898 TMEM50A transmembrane protein 50A 1 25537397 NM_014313 1p36.11 Hs.523054 13

cytoplasm

endoplasmic reticulum

membrane

integral to membrane

 
240329_at -0.323 4.539 -2.913 1.058e-02 0.418 -2.604 LOC727916 hypothetical protein LOC727916 6   AW136267 6q12 Hs.706850 1    
1554476_x_at ZNF808 zinc finger protein 808 19 57722720 BC033230 19q13.41 Hs.235167 2

DNA binding

intracellular

nucleus

transcription

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
201991_s_at KIF5B kinesin family member 5B 10 -32337943 BF223224 10pter-q22.1 Hs.644646 36

nucleotide binding

microtubule motor activity

protein binding

ATP binding

cytoplasm

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

cytoplasm organization

microtubule binding

ciliary rootlet

neuron projection

membrane-bounded organelle

vesicle transport along microtubule

perinuclear region of cytoplasm

 
212263_at QKI quaking homolog, KH domain RNA binding (mouse) 6 163755664, 163755664 AI114716 6q26 6q26-q27 Hs.510324 Hs.593520 23

RNA binding

protein binding

nucleus

nucleolus

cytoplasm

plasma membrane

mRNA processing

regulation of translation

transport

multicellular organismal development

RNA splicing

SH3 domain binding

cell differentiation

mRNA transport

 
234027_at CCDC129 coiled-coil domain containing 129 7 31523502 AI184130 7p14.3 Hs.224269 2    
222231_s_at 0.468 6.555 3.203 5.839e-03 0.357 -2.099 LRRC59 leucine rich repeat containing 59 17 -45813597 AK025328 17q21.33 Hs.370927 6

protein binding

endoplasmic reticulum

microsome

membrane

integral to membrane

mitochondrial nucleoid

 
205841_at JAK2 Janus kinase 2 9 4975244 NM_004972 9p24 Hs.656213 588

nucleotide binding

non-membrane spanning protein tyrosine kinase activity

Janus kinase activity

receptor binding

growth hormone receptor binding

interleukin-12 receptor binding

ATP binding

nucleus

cytoplasm

cytoskeleton

caveola

apoptosis

cell motion

enzyme linked receptor protein signaling pathway

tyrosine phosphorylation of STAT protein

STAT protein nuclear translocation

mesoderm development

negative regulation of cell proliferation

positive regulation of phosphoinositide 3-kinase cascade

membrane

transferase activity

myeloid cell differentiation

SH2 domain binding

positive regulation of tyrosine phosphorylation of Stat3 protein

positive regulation of tyrosine phosphorylation of Stat5 protein

negative regulation of DNA binding

response to antibiotic

positive regulation of peptidyl-tyrosine phosphorylation

JAK-STAT cascade involved in growth hormone signaling pathway

positive regulation of growth hormone receptor signaling pathway

Chemokine signaling pathway

Jak-STAT signaling pathway

Adipocytokine signaling pathway

229344_x_at RIMKLB ribosomal modification protein rimK-like family member B 12 8741784 AW135012 12p13.31 Hs.504670 4

nucleotide binding

catalytic activity

ATP binding

protein modification process

manganese ion binding

metal ion binding

 
207236_at ZNF345 zinc finger protein 345 19 42033106 NM_003419 19q13.12 Hs.362324 5

negative regulation of transcription from RNA polymerase II promoter

DNA binding

specific RNA polymerase II transcription factor activity

RNA polymerase III transcription factor activity

intracellular

nucleus

regulation of transcription from RNA polymerase III promoter

zinc ion binding

regulation of transcription

metal ion binding

 
202383_at KDM5C lysine (K)-specific demethylase 5C X -53237228 NM_004187 Xp11.22-p11.21 Hs.631768 17

molecular_function

DNA binding

iron ion binding

protein binding

cellular_component

intracellular

nucleus

biological_process

zinc ion binding

oxidoreductase activity

chromatin modification

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

regulation of transcription

metal ion binding

oxidation reduction

 
215590_x_at -0.431 6.356 -2.655 1.784e-02 0.475 -3.046 LOC100128640 hypothetical protein LOC100128640 3   AK025619 3p22.2        
216924_s_at DRD2 dopamine receptor D2 11 -112785526 S62137 11q23 Hs.73893 519

temperature homeostasis

dopamine D2 receptor activity

response to amphetamine

neurological system process involved in regulation of systemic arterial blood pressure

regulation of heart rate

regulation of sodium ion transport

positive regulation of neuroblast proliferation

receptor activity

G-protein coupled receptor activity

dopamine receptor activity

protein binding

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

nerve-nerve synaptic transmission

axonogenesis

synaptogenesis

sensory perception of smell

locomotory behavior

adult walking behavior

protein localization

drug binding

negative regulation of cell proliferation

associative learning

visual learning

response to light stimulus

cerebral cortex GABAergic interneuron migration

adenohypophysis development

diuresis

natriuresis

negative regulation of cell migration

phosphoinositide metabolic process

axon

dendrite

peristalsis

regulation of cAMP metabolic process

regulation of synaptic transmission, GABAergic

circadian regulation of gene expression

response to histamine

dopamine metabolic process

response to drug

regulation of potassium ion transport

response to morphine

negative regulation of blood pressure

behavioral response to cocaine

behavioral response to ethanol

regulation of long-term neuronal synaptic plasticity

branching morphogenesis of a nerve

arachidonic acid secretion

negative regulation of protein secretion

release of sequestered calcium ion into cytosol

positive regulation of dopamine uptake

negative regulation of protein kinase B signaling cascade

negative regulation of synaptic transmission, glutamatergic

positive regulation of growth hormone secretion

prepulse inhibition

activation of phospholipase C activity by dopamine receptor signaling pathway

negative regulation of dopamine receptor signaling pathway

Neuroactive ligand-receptor interaction

Gap junction

1554033_at FRMD4A FERM domain containing 4A 10 -13725711 BC018891 10p13 Hs.330463 Hs.656573 3

binding

cytoplasm

cytoskeleton

 
221474_at 0.472 10.442 3.486 3.256e-03 0.306 -1.602 MYL12B myosin, light chain 12B, regulatory 18 3252110, 3252610, 3252716 U26162 18p11.31 Hs.190086 Hs.464472 7

motor activity

calcium ion binding

myosin complex

apical part of cell

Focal adhesion

Tight junction

Leukocyte transendothelial migration

Regulation of actin cytoskeleton

216480_x_at MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 10 21863107, 21863579 AF060927 10p12 Hs.30385 19

transcription factor activity

protein binding

nucleus

cytoplasm

zinc ion binding

metal ion binding

 
237565_at GCC2 GRIP and coiled-coil domain containing 2 2 108432008, 108432067 AI651345 2q12.3 Hs.436505 Hs.469630 19

cytoplasm

Golgi apparatus

membrane

identical protein binding

 
209304_x_at GADD45B growth arrest and DNA-damage-inducible, beta 19 2427134 AF087853 19p13.3 Hs.110571 33

activation of MAPKKK activity

activation of MAPKK activity

protein binding

negative regulation of protein kinase activity

apoptosis

response to stress

multicellular organismal development

cell differentiation

regulation of cell cycle

MAPK signaling pathway

Cell cycle

p53 signaling pathway

227456_s_at C6orf136 chromosome 6 open reading frame 136 6 30722794, 2063373, 1861669 BF224092 6p21.33 Hs.591787 7    
229596_at -0.539 3.961 -2.782 1.382e-02 0.441 -2.830 AMDHD1 amidohydrolase domain containing 1 12 94861201 AW271617 12q23.1 Hs.424907 4

iron ion binding

cytoplasm

cytosol

histidine metabolic process

zinc ion binding

histidine catabolic process to glutamate and formamide

metal ion binding

imidazolonepropionase activity

Histidine metabolism

Metabolic pathways

225766_s_at TNPO1 transportin 1 5 72148173, 72179685 AA527296 5q13.2 Hs.482497 58

protein import into nucleus, docking

protein import into nucleus, translocation

protein binding

nucleus

nuclear pore

cytoplasm

nuclear localization sequence binding

protein transporter activity

interspecies interaction between organisms

 
228163_at ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 9 -129709985 BE858453 9q34 Hs.3972 Hs.709827 13

soluble fraction

nucleus

Golgi apparatus

protein amino acid glycosylation

glycolipid metabolic process

membrane

integral to membrane

integral to Golgi membrane

(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity

Glycosphingolipid biosynthesis - ganglio series

Metabolic pathways

228696_at SLC45A3 solute carrier family 45, member 3 1 -203893603 AA631143 1q32.1 Hs.278695 9

transport

membrane

integral to membrane

 
209476_at TMX1 thioredoxin-related transmembrane protein 1 14 50776635 AL080080 14q22.1 Hs.125221 10

membrane fraction

nucleus

endoplasmic reticulum

endoplasmic reticulum membrane

DNA replication

transport

ER to Golgi vesicle-mediated transport

anti-apoptosis

response to stress

signal transduction

cell proliferation

disulfide oxidoreductase activity

membrane

integral to membrane

electron transport chain

arsenate reductase (thioredoxin) activity

leukocyte activation

cell redox homeostasis

positive regulation of transcription, DNA-dependent

positive regulation of growth

 
225855_at EPB41L5 erythrocyte membrane protein band 4.1 like 5 2 120487138 AB046768 2q14.2 Hs.654802 5

binding

cytoplasm

cytoskeleton

adherens junction

cytoskeletal protein binding

extrinsic to membrane

cell junction

 
239317_at CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 19 46774370 BG484601 19q13.2 Hs.655885 3

membrane

integral to membrane

 
202515_at DLG1 discs, large homolog 1 (Drosophila) 3 -198253827 BG251175 3q29 Hs.292549 95

endothelial cell proliferation

guanylate kinase activity

phosphoprotein phosphatase activity

endoplasmic reticulum

endoplasmic reticulum membrane

cell-cell junction

actin filament organization

establishment or maintenance of cell polarity

protein C-terminus binding

cytoskeletal protein binding

postsynaptic density

potassium channel regulator activity

basolateral plasma membrane

cell-cell adhesion

protein kinase binding

phosphatase binding

cortical actin cytoskeleton organization

G1/S transition checkpoint

sarcolemma

interspecies interaction between organisms

synapse

postsynaptic membrane

negative regulation of mitotic cell cycle

T cell receptor signaling pathway

225008_at ASPH aspartate beta-hydroxylase 8 -62739837, -62699648, -62699648, -62575669 AW469351 8q12.1 Hs.591874 24

peptide-aspartate beta-dioxygenase activity

binding

iron ion binding

calcium ion binding

endoplasmic reticulum

endoplasmic reticulum membrane

muscle contraction

pattern specification process

negative regulation of cell proliferation

structural constituent of muscle

electron carrier activity

membrane

integral to membrane

oxidoreductase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

peptidyl-amino acid modification

integral to endoplasmic reticulum membrane

limb morphogenesis

peptidyl-aspartic acid hydroxylation

oxidation reduction

palate development

face morphogenesis

 
238987_at B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 9 -33100638 AL574435 9p13 Hs.272011 41

Golgi trans cisterna

epithelial cell development

acute inflammatory response

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity

N-acetyllactosamine synthase activity

lactose synthase activity

extracellular region

Golgi apparatus

plasma membrane

carbohydrate metabolic process

lactose biosynthetic process

galactose metabolic process

protein amino acid terminal N-glycosylation

cell adhesion

binding of sperm to zona pellucida

penetration of zona pellucida

cytoskeletal protein binding

negative regulation of cell proliferation

glycoprotein biosynthetic process

oligosaccharide biosynthetic process

oligosaccharide biosynthetic process

external side of plasma membrane

integral to membrane

basolateral plasma membrane

transferase activity, transferring glycosyl groups

desmosome

glycocalyx

manganese ion binding

extracellular matrix organization

mammary gland development

brush border membrane

development of secondary sexual characteristics

metal ion binding

branching morphogenesis of a tube

leukocyte migration

regulation of cell motion

regulation of acrosome reaction

positive regulation of epithelial cell proliferation involved in wound healing

angiogenesis involved in wound healing

positive regulation of apoptosis involved in mammary gland involution

Galactose metabolism

N-Glycan biosynthesis

Keratan sulfate biosynthesis

Glycosphingolipid biosynthesis - lacto and neolacto series

Metabolic pathways

219839_x_at -0.268 4.571 -2.884 1.123e-02 0.426 -2.655 TCL6 T-cell leukemia/lymphoma 6 14 95187267, 95187267, 95199345, 95199345, 95199345 NM_012468 14q32.1 Hs.510368 4

molecular_function

cellular_component

biological_process

 
229435_at 0.558 3.363 3.545 2.885e-03 0.297 -1.499 GLIS3 GLIS family zinc finger 3 9 -3814127, -3814127 AW025602 9p24.2 Hs.162125 Hs.644570 8

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

specific RNA polymerase II transcription factor activity

intracellular

zinc ion binding

nuclear part

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

metal ion binding

 
227137_at -0.287 3.105 -2.236 4.076e-02 0.570 -3.736 C10orf46 chromosome 10 open reading frame 46 10 -120430483 N25937 10q26.11 Hs.719193 4

ubiquitin-dependent protein catabolic process

cullin-RING ubiquitin ligase complex

ubiquitin protein ligase binding

 
211466_at NFIB nuclear factor I/B 9 -14071846 U70862 9p24.1 Hs.644095 13

transcription factor activity

intracellular

nucleus

nucleolus

DNA replication

regulation of transcription, DNA-dependent

 
209194_at CETN2 centrin, EF-hand protein, 2 X -151746526 BC005334 Xq28 Hs.82794 34

calcium ion binding

protein binding

intracellular

centriole

microtubule basal body

cell cycle

mitosis

centriole replication

G-protein beta/gamma-subunit binding

photoreceptor connecting cilium

regulation of cytokinesis

cell division

Nucleotide excision repair

202907_s_at NBN nibrin 8 -91014739 NM_002485 8q21 Hs.492208 222

DNA damage checkpoint

telomere maintenance

nuclear chromosome, telomeric region

in utero embryonic development

blastocyst growth

damaged DNA binding

intracellular

nucleus

nucleoplasm

replication fork

chromosome

nucleolus

Golgi apparatus

double-strand break repair

response to DNA damage stimulus

cell cycle

cell cycle arrest

mitotic cell cycle G2/M transition DNA damage checkpoint

meiosis

transcription factor binding

cell proliferation

regulation of DNA replication initiation

DNA damage response, signal transduction by p53 class mediator

Mre11 complex

G1/S transition checkpoint

nuclear inclusion body

isotype switching

protein N-terminus binding

regulation of fibroblast proliferation

neuromuscular process controlling balance

Homologous recombination

202939_at ZMPSTE24 zinc metallopeptidase (STE24 homolog, S. cerevisiae) 1 40496319 NM_005857 1p34 Hs.132642 Hs.591501 22

metalloendopeptidase activity

cytoplasm

endoplasmic reticulum

Golgi apparatus

proteolysis

peptidase activity

metalloexopeptidase activity

zinc ion binding

membrane

integral to membrane

metal ion binding

 
235222_x_at XIAP X-linked inhibitor of apoptosis X 122821728 AW675725 Xq25 Hs.356076 170

protein binding

intracellular

cytoplasm

cytosol

cytosol

apoptosis

anti-apoptosis

zinc ion binding

ligase activity

modification-dependent protein catabolic process

peptidase inhibitor activity

caspase inhibitor activity

metal ion binding

Ubiquitin mediated proteolysis

Apoptosis

Focal adhesion

Pathways in cancer

Small cell lung cancer

228480_at VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 18 9903954 AW296039 18p11.22 Hs.699980 18

signal transducer activity

structural molecule activity

protein binding

membrane fraction

endoplasmic reticulum

microtubule

plasma membrane

tight junction

membrane fusion

integral to membrane

vesicle

positive regulation of I-kappaB kinase/NF-kappaB cascade

protein heterodimerization activity

perinuclear region of cytoplasm

Tight junction

209397_at 0.514 8.992 2.775 1.403e-02 0.443 -2.843 ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 18 46659432 BC000147 18q21 6p25-p24 Hs.233119 24

malate dehydrogenase (decarboxylating) activity

binding

mitochondrion

mitochondrial matrix

malate metabolic process

electron carrier activity

oxidoreductase activity

malate dehydrogenase (oxaloacetate-decarboxylating) activity

metal ion binding

NAD or NADH binding

oxidation reduction

Pyruvate metabolism

Biosynthesis of phenylpropanoids

Biosynthesis of alkaloids derived from terpenoid and polyketide

206776_x_at -0.186 3.178 -2.140 4.895e-02 0.590 -3.886 ACRV1 acrosomal vesicle protein 1 11 -125047438 NM_001612 11q23-q24 Hs.169222 Hs.596575 12

acrosomal vesicle

multicellular organismal development

 
217315_s_at KLK13 kallikrein-related peptidase 13 19 -56251274 AL050220 19q13.3-q13.4 Hs.165296 18

serine-type endopeptidase activity

protein binding

extracellular region

cytoplasm

proteolysis

peptidase activity

 
226597_at REEP6 receptor accessory protein 6 19 1442164 AI348159 19p13.3 Hs.76277 6

membrane

integral to membrane

 
214719_at 0.284 6.682 2.871 1.154e-02 0.426 -2.677 SLC46A3 solute carrier family 46, member 3 13 -28172219 AK026720 13q12.3 Hs.117167 5

membrane

integral to membrane

 
1558027_s_at PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 1 -145093308 AL552001 1q21.1 Hs.50732 21

protein binding

nucleoplasm

cytosol

cAMP-dependent protein kinase complex

fatty acid biosynthetic process

signal transduction

protein kinase binding

AMP-activated protein kinase complex

regulation of fatty acid oxidation

Insulin signaling pathway

Adipocytokine signaling pathway

Hypertrophic cardiomyopathy (HCM)

228578_at RBM45 RNA binding motif protein 45 2 178685427 AI471723 2q31.2 Hs.377257 3

nucleotide binding

RNA binding

nucleus

cytoplasm

multicellular organismal development

nervous system development

cell differentiation

 
225851_at FNTB farnesyltransferase, CAAX box, beta 14 64523259 BF131248 14q23-q24 Hs.632345 26

farnesyltranstransferase activity

protein farnesyltransferase activity

protein binding

zinc ion binding

negative regulation of cell proliferation

transferase activity

protein amino acid farnesylation

wound healing

metal ion binding

positive regulation of fibroblast proliferation

 
216845_x_at -0.277 6.675 -3.235 5.465e-03 0.352 -2.042 MLL2 myeloid/lymphoid or mixed-lineage leukemia 2 12 -47699024 U80756 12q12-q14 Hs.120228 16

in utero embryonic development

DNA binding

protein binding

nucleus

regulation of transcription, DNA-dependent

methyltransferase activity

zinc ion binding

chromatin modification

transferase activity

histone-lysine N-methyltransferase activity

histone methyltransferase complex

metal ion binding

 
203321_s_at ADNP2 ADNP homeobox 2 18 75967902 AK022688 18q23 Hs.131915 5

transcription factor activity

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
201916_s_at SEC63 SEC63 homolog (S. cerevisiae) 6 -108295652 NM_007214 6q21 Hs.26904 14

receptor activity

endoplasmic reticulum

protein folding

protein targeting to membrane

protein transport

membrane

integral to membrane

heat shock protein binding

unfolded protein binding

 
219368_at NAP1L2 nucleosome assembly protein 1-like 2 X -72348878 NM_021963 Xq13 Hs.66180 Hs.719281 4

nucleus

chromatin assembly complex

nucleosome assembly

 
209991_x_at GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 9 -100090186 AF069755 9q22.1-q22.3 Hs.198612 27

receptor activity

G-protein coupled receptor activity

GABA-B receptor activity

protein binding

cytoplasm

plasma membrane

integral to plasma membrane

signal transduction

negative regulation of adenylate cyclase activity

gamma-aminobutyric acid signaling pathway

synaptic transmission

cell junction

neuron projection

synapse

postsynaptic membrane

Neuroactive ligand-receptor interaction

223391_at SGPP1 sphingosine-1-phosphate phosphatase 1 14 -63220687 BE880703 14q23.2 Hs.24678 11

membrane fraction

endoplasmic reticulum

sphingolipid metabolic process

sphinganine-1-phosphate metabolic process

sphingosine metabolic process

apoptosis

membrane

integral to membrane

hydrolase activity

sphingosine-1-phosphate phosphatase activity

Sphingolipid metabolism

214643_x_at BIN1 bridging integrator 1 2 -127522077, -127522076 BG034080 2q14 Hs.193163 69

protein binding

nucleus

cytoplasm

multicellular organismal development

cell proliferation

actin cytoskeleton

regulation of endocytosis

cell differentiation

interspecies interaction between organisms

 
226784_at 0.302 5.732 2.691 1.659e-02 0.465 -2.985 TWISTNB TWIST neighbor 7 -19701609 AA121481 7p21.1 Hs.353035 5

DNA-directed RNA polymerase activity

nucleus

nucleolus

transcription

 
226234_at 0.504 3.807 4.680 2.854e-04 0.175 0.450 GDF11 growth differentiation factor 11 12 54423330 D80983 12q13.2 Hs.600883 10

skeletal system development

ureteric bud development

cytokine activity

protein binding

extracellular region

extracellular space

nervous system development

mesoderm development

growth factor activity

negative regulation of cell proliferation

organ morphogenesis

spinal cord anterior/posterior patterning

pancreas development

growth

negative regulation of cell differentiation

cell maturation

camera-type eye morphogenesis

 
204012_s_at LCMT2 leucine carboxyl methyltransferase 2 15 -41407265 AL529189 15q15.3 Hs.200596 10

protein binding

tRNA processing

methyltransferase activity

transferase activity

Androgen and estrogen metabolism

Histidine metabolism

Tyrosine metabolism

Aminophosphonate metabolism

Selenoamino acid metabolism

213098_at -0.217 5.416 -2.522 2.329e-02 0.507 -3.270 RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe) 2 219141921 AI567462 2q35 Hs.148767 6

protein binding

nucleus

sex differentiation

cytokine-mediated signaling pathway

regulation of transcription

RNA degradation

230033_at 0.464 4.647 3.411 3.805e-03 0.319 -1.734 C19orf51 chromosome 19 open reading frame 51 19 -60361842 BF436398 19q13.4 Hs.351582 2    
218496_at RNASEH1 ribonuclease H1 2 -3570565 BG534527 2p25 Hs.568006 20

magnesium ion binding

RNA binding

endonuclease activity

ribonuclease H activity

ribonuclease activity

cytoplasm

mitochondrion

RNA catabolic process

hydrolase activity

DNA replication

215960_at SLC5A4 solute carrier family 5 (low affinity glucose cotransporter), member 4 22 -30944464 AJ133127 22q12.2-q12.3 Hs.130101 8

transporter activity

ion transport

sodium ion transport

carbohydrate transport

symporter activity

membrane

integral to membrane

sodium ion binding

 
231741_at S1PR3 sphingosine-1-phosphate receptor 3 9 90796181 NM_005226 9q22.1-q22.2 Hs.585118 31

lysosphingolipid and lysophosphatidic acid receptor activity

cytokine production

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

inflammatory response

signal transduction

G-protein coupled receptor protein signaling pathway

inhibition of adenylate cyclase activity by G-protein signaling

elevation of cytosolic calcium ion concentration

positive regulation of cell proliferation

lipid binding

anatomical structure morphogenesis

regulation of interleukin-1 beta production

Neuroactive ligand-receptor interaction

1558034_s_at CP ceruloplasmin (ferroxidase) 3 -150372979 AL556703 3q23-q25 Hs.558314 95

ferroxidase activity

copper ion binding

extracellular region

extracellular space

ion transport

copper ion transport

cellular iron ion homeostasis

aging

response to nutrient

oxidoreductase activity

anchored to plasma membrane

metal ion binding

oxidation reduction

Porphyrin and chlorophyll metabolism

241280_at ALDOB aldolase B, fructose-bisphosphate 9 -103222662 AV650426 9q21.3-q22.2 Hs.530274 40

fructose-bisphosphate aldolase activity

microtubule organizing center

glycolysis

NADH oxidation

cytoskeletal protein binding

metabolic process

lyase activity

fructose 1,6-bisphosphate metabolic process

positive regulation of ATPase activity

centriolar satellite

identical protein binding

ATPase binding

fructose binding

vacuolar proton-transporting V-type ATPase complex assembly

Glycolysis / Gluconeogenesis

Pentose phosphate pathway

Fructose and mannose metabolism

Carbon fixation in photosynthetic organisms

Biosynthesis of phenylpropanoids

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from shikimate pathway

Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

201243_s_at 0.414 11.157 2.732 1.528e-02 0.457 -2.915 ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 1 167342570 NM_001677 1q24 Hs.291196 34

response to hypoxia

sodium:potassium-exchanging ATPase activity

protein binding

plasma membrane

sodium:potassium-exchanging ATPase complex

ATP biosynthetic process

ion transport

potassium ion transport

sodium ion transport

integral to membrane

basolateral plasma membrane

potassium ion binding

sodium ion binding

Cardiac muscle contraction

226804_at 0.328 4.386 2.476 2.549e-02 0.516 -3.345 FAM20A family with sequence similarity 20, member A 17 -64042852, -64042852 AI632223 17q24.2 Hs.268874 5

extracellular region

 
227444_at ARMCX4 armadillo repeat containing, X-linked 4 X   AW519141 Xq22.1 Hs.709762 4

membrane

integral to membrane

 
213966_at HMG20B high-mobility group 20B 19 3523942 N25429 19p13.3 Hs.406534 18

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

cell cycle

chromatin modification

 
243508_at 0.281 4.338 2.520 2.337e-02 0.507 -3.273 C20orf196 chromosome 20 open reading frame 196 20 5679042 AV715251 20p12.3 Hs.529340 1    
200596_s_at EIF3A eukaryotic translation initiation factor 3, subunit A 10 -120784530 BE614908 10q26 Hs.523299 38

formation of translation initiation complex

translation initiation factor activity

translation initiation factor activity

structural molecule activity

protein binding

nucleus

cytoplasm

cytosol

eukaryotic translation initiation factor 3 complex

 
235777_at ANKRD44 ankyrin repeat domain 44 2 -197567494 AI985590 2q33.1 Hs.654819 6

protein binding

 
230722_at 0.407 5.563 2.333 3.375e-02 0.552 -3.580 BNC2 basonuclin 2 9 -16399500 AI377043 9p22.3-p22.2 Hs.656581 Hs.693437 10

intracellular

nucleus

cytoplasm

plasma membrane

zinc ion binding

regulation of transcription

metal ion binding

 
226208_at 0.705 6.233 2.809 1.308e-02 0.433 -2.784 ZSWIM6 zinc finger, SWIM-type containing 6 5 60663856 AI692595 5q12.1 Hs.650537 5

zinc ion binding

metal ion binding

 
1553265_at -0.268 3.185 -2.662 1.761e-02 0.473 -3.035 SLC23A3 solute carrier family 23 (nucleobase transporters), member 3 2 -219734426 NM_144712 2q35 Hs.124565 5

transporter activity

transport

membrane

integral to membrane

 
223084_s_at CCNDBP1 cyclin D-type binding-protein 1 15 41264757, 41265429 AF246144 15q14-q15 Hs.36794 Hs.368642 Hs.688009 19

protein binding

nucleus

cytoplasm

cell cycle

 
234305_s_at GSDMC gasdermin C 8 -130829623 AJ245876 8q24.1-q24.2 Hs.133244 7

molecular_function

cytoplasm

biological_process

 
216080_s_at 1.087 5.863 3.741 1.923e-03 0.273 -1.154 FADS3 fatty acid desaturase 3 11 -61397573 AC004770 11q12-q13.1 Hs.21765 6

molecular_function

membrane fraction

endoplasmic reticulum

unsaturated fatty acid biosynthetic process

transport

membrane

integral to membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

heme binding

electron transport chain

 
209029_at 0.341 7.786 2.770 1.415e-02 0.445 -2.850 COPS7A COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 12 6703410, 6703440, 6703505, 6703709 AF193844 12p13.31 Hs.530823 16

nucleus

cytoplasm

signalosome

 
210044_s_at LYL1 lymphoblastic leukemia derived sequence 1 19 -13070846 BC002796 19p13.2 Hs.46446 15

DNA binding

nucleus

transcription regulator activity

regulation of transcription

 
208203_x_at -0.357 5.783 -4.003 1.124e-03 0.229 -0.699 KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 19 240800 NM_014513 19q13.4 Hs.714920 48

receptor activity

plasma membrane

integral to plasma membrane

immune response

HLA-C specific inhibitory MHC class I receptor activity

Antigen processing and presentation

Natural killer cell mediated cytotoxicity

213119_at 0.593 6.281 2.465 2.607e-02 0.518 -3.364 SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 5 150807355 AW058600 5q33.1 Hs.269004 19

hydrogen:amino acid symporter activity

lysosome

endoplasmic reticulum

plasma membrane

transport

amino acid transport

hydrogen ion transmembrane transporter activity

L-alanine transmembrane transporter activity

glycine transmembrane transporter activity

L-proline transmembrane transporter activity

symporter activity

L-alanine transport

glycine transport

proline transport

proton transport

integral to membrane

 
200991_s_at 0.548 7.593 3.005 8.771e-03 0.394 -2.445 SNX17 sorting nexin 17 2 27446892 NM_014748 2p23-p22 Hs.278569 18

receptor binding

cytoplasm

early endosome

Golgi apparatus

cholesterol catabolic process

intracellular protein transport

receptor-mediated endocytosis

signal transduction

protein C-terminus binding

membrane

endosome transport

regulation of endocytosis

phosphoinositide binding

low-density lipoprotein receptor binding

 
209732_at 0.812 7.902 2.462 2.619e-02 0.520 -3.368 CLEC2B C-type lectin domain family 2, member B 12 -9896234 BC005254 12p13-p12 Hs.85201 10

binding

sugar binding

integral to plasma membrane

membrane

 
207327_at 0.270 5.525 2.347 3.288e-02 0.550 -3.558 EYA4 eyes absent homolog 4 (Drosophila) 6 133604187 NM_004100 6q23 Hs.596680 15

magnesium ion binding

protein tyrosine phosphatase activity

nucleus

cytoplasm

DNA repair

response to DNA damage stimulus

multicellular organismal development

visual perception

metabolic process

anatomical structure morphogenesis

chromatin modification

hydrolase activity

regulation of transcription

 
227627_at SGK3 serum/glucocorticoid regulated kinase family, member 3 8 67787444, 67850015 AV690866 8q12.3-q13.1 Hs.613417 30

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

early endosome

protein amino acid phosphorylation

response to stress

cell communication

transferase activity

cytoplasmic vesicle

phosphoinositide binding

 
218241_at GOLGA5 golgi autoantigen, golgin subfamily a, 5 14 92330402 NM_005113 14q32.12-q32.13 Hs.104320 14

Golgi membrane

protein tyrosine kinase activity

protein binding

ATP binding

Golgi apparatus

cis-Golgi network

protein amino acid phosphorylation

Golgi organization

membrane

integral to membrane

Rab GTPase binding

Golgi cisterna

protein homodimerization activity

Golgi vesicle transport

 
1559731_x_at -0.353 5.544 -2.982 9.192e-03 0.400 -2.485 MACROD1 MACRO domain containing 1 11 -63522606 AL833017 11q11 Hs.602898 12

mitochondrion

 
203256_at -0.354 5.599 -2.638 1.848e-02 0.484 -3.076 CDH3 cadherin 3, type 1, P-cadherin (placental) 16 67235651 NM_001793 16q22.1 Hs.191842 56

calcium ion binding

protein binding

plasma membrane

cell-cell adherens junction

homophilic cell adhesion

visual perception

integral to membrane

response to stimulus

Cell adhesion molecules (CAMs)

1565554_at LOC127841 hypothetical protein LOC127841 1 -202604180 BC015457 1q32.1 Hs.213144 1    
222220_s_at TSNAXIP1 translin-associated factor X interacting protein 1 16 66398510 AK027245 16q22.1 Hs.632212 3

cytoplasm

multicellular organismal development

spermatogenesis

cell differentiation

perinuclear region of cytoplasm

 
209216_at WDR45 WD repeat domain 45 X -48819035, -48819035 BC000464 Xp11.23 Hs.632807 8    
235692_at SH3KBP1 SH3-domain kinase binding protein 1 X -19462003, -19462003 AW024527 Xp22.1-p21.3 Hs.719268 58

molecular_function

protein binding

nucleus

nucleolus

cytoplasm

cytosol

cytoskeleton

plasma membrane

focal adhesion

endocytosis

apoptosis

cell-cell signaling

SH3 domain binding

synaptosome

cell junction

cytoplasmic vesicle

synapse

Endocytosis

228204_at 0.355 6.514 2.156 4.750e-02 0.585 -3.862 PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 1 149638664 AA630330 1q21 Hs.89545 46

threonine-type endopeptidase activity

nucleus

cytoplasm

centrosome

cytosol

proteasome core complex

cytoskeleton

peptidase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

proteolysis involved in cellular protein catabolic process

Proteasome

227055_at 1.201 6.216 3.352 4.296e-03 0.328 -1.838 METTL7B methyltransferase like 7B 12 54361596 AI827972 12q13.2 Hs.51483 3

metabolic process

methyltransferase activity

transferase activity

 
222908_at FAM38B family with sequence similarity 38, member B 18 -10660859 AW269818 18p11.22 Hs.585839 1

membrane

integral to membrane

 
220579_at -0.323 4.036 -2.779 1.389e-02 0.442 -2.834 FLJ14100 hypothetical protein FLJ14100 1   NM_025025 1p36.33 Hs.711221 1    
236703_at NT5C2 5'-nucleotidase, cytosolic II 10 -104835929 BF114733 10q24.32-q24.33 Hs.97439 12

nucleotide binding

magnesium ion binding

protein binding

cytoplasm

cytosol

5'-nucleotidase activity

5'-nucleotidase activity

nucleotide metabolic process

hydrolase activity

Purine metabolism

Pyrimidine metabolism

Nicotinate and nicotinamide metabolism

Biosynthesis of alkaloids derived from histidine and purine

Metabolic pathways

222868_s_at IL18BP interleukin 18 binding protein 11 71387605, 71387756, 71388310, 71388620 AI521549 11q13 Hs.591967 22

extracellular region

interleukin-18 binding

T-helper 1 type immune response

receptor antagonist activity

 
218583_s_at DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 3 -184143252 NM_020640 3q26.3 Hs.715661 16

molecular_function

cellular_component

biological_process

modification-dependent protein catabolic process

 
200938_s_at RERE arginine-glutamic acid dipeptide (RE) repeats 1 -8335050, -8335050 AI920976 1p36.2-p36.1 Hs.463041 17

histone deacetylase complex

transcription factor activity

nucleus

chromatin remodeling

regulation of transcription, DNA-dependent

NLS-bearing substrate import into nucleus

multicellular organismal development

poly-glutamine tract binding

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
1555154_a_at QKI quaking homolog, KH domain RNA binding (mouse) 6 163755664, 163755664 AF142421 6q26 6q26-q27 Hs.510324 Hs.593520 23

RNA binding

protein binding

nucleus

nucleolus

cytoplasm

plasma membrane

mRNA processing

regulation of translation

transport

multicellular organismal development

RNA splicing

SH3 domain binding

cell differentiation

mRNA transport

 
229805_at -0.231 5.187 -2.233 4.096e-02 0.571 -3.740 ZDHHC22 zinc finger, DHHC-type containing 22 14 -76667365 AI363193 14q24.3 Hs.525485 5

zinc ion binding

acyltransferase activity

membrane

integral to membrane

transferase activity

metal ion binding

 
210759_s_at 0.331 9.928 3.464 3.407e-03 0.308 -1.640 PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 11 -14492087, -14482998, -14482998 M64992 11p15.1 Hs.102798 Hs.445711 52

RNA binding

threonine-type endopeptidase activity

protein binding

nucleus

cytoplasm

cytosol

proteasome core complex

polysome

ubiquitin-dependent protein catabolic process

peptidase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

proteolysis involved in cellular protein catabolic process

Proteasome

225379_at 0.291 8.104 2.180 4.536e-02 0.581 -3.824 MAPT microtubule-associated protein tau 17 41327543 AA199717 17q21.1 Hs.101174 545

microtubule cytoskeleton organization

microtubule cytoskeleton organization

structural constituent of cytoskeleton

cytoplasm

cytosol

cytoskeleton

microtubule

microtubule associated complex

plasma membrane

plasma membrane

negative regulation of microtubule depolymerization

microtubule binding

microtubule binding

lipoprotein binding

SH3 domain binding

enzyme binding

axon

axon

growth cone

growth cone

positive regulation of microtubule polymerization

positive regulation of microtubule polymerization

apolipoprotein E binding

identical protein binding

cell projection

tubulin complex

tubulin complex

positive regulation of axon extension

positive regulation of axon extension

generation of neurons

MAPK signaling pathway

Alzheimer's disease

203739_at ZNF217 zinc finger protein 217 20 -51617016 NM_006526 20q13.2 Hs.155040 Hs.711564 18

transcription factor activity

intracellular

nucleus

transcription, DNA-dependent

zinc ion binding

regulation of transcription

metal ion binding

 
222960_at CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 16 1143241 AF175522 16p13.3 Hs.459642 44

voltage-gated ion channel activity

calcium ion binding

voltage-gated calcium channel complex

ion transport

calcium ion transport

muscle contraction

muscle organ development

myoblast fusion

regulation of heart contraction

low voltage-gated calcium channel activity

membrane

integral to membrane

MAPK signaling pathway

Calcium signaling pathway

211002_s_at TRIM29 tripartite motif-containing 29 11 -119487203 AF230389 11q22-q23 Hs.504115 20

transcription factor activity

protein binding

intracellular

cytoplasm

transcription from RNA polymerase II promoter

zinc ion binding

metal ion binding

 
234598_at DKFZp564H213 hypothetical gene supported by AL049275 17   AL049275 17q12 Hs.302051 1    
1557821_at -0.191 3.139 -2.433 2.776e-02 0.527 -3.417 LOC283547 hypothetical protein LOC283547 14   BC035119 14q21.1 Hs.675941 1    
227888_at RRBP1 ribosome binding protein 1 homolog 180kDa (dog) 20 -17542322 AA534989 20p12 Hs.472213 19

receptor activity

endoplasmic reticulum

ribosome

translation

signal transduction

protein transport

membrane

integral to membrane

integral to endoplasmic reticulum membrane

intracellular protein transmembrane transport

 
230721_at -0.272 5.654 -2.255 3.930e-02 0.567 -3.706 C16orf52 chromosome 16 open reading frame 52 16 21927030 BF436957 16p12.2 Hs.498890 3    
203687_at CX3CL1 chemokine (C-X3-C motif) ligand 1 16 55963914 NM_002996 16q13 Hs.531668 100

extracellular region

extracellular space

plasma membrane

chemotaxis

defense response

immune response

cell adhesion

chemokine activity

cell surface

integral to membrane

cytokine-mediated signaling pathway

leukocyte chemotaxis

positive regulation of inflammatory response

leukocyte adhesive activation

positive regulation of calcium-independent cell-cell adhesion

Cytokine-cytokine receptor interaction

Chemokine signaling pathway

232046_at 0.452 6.432 2.898 1.092e-02 0.423 -2.631 KIAA1217 KIAA1217 10 24023680, 24537725 AU148164 10p12.2-p12.1 Hs.445885 5

molecular_function

cytoplasm

multicellular organismal development

embryonic skeletal system development

 
207064_s_at -0.261 4.253 -2.338 3.342e-02 0.552 -3.571 AOC2 amine oxidase, copper containing 2 (retina-specific) 17 38250134 NM_009590 17q21 Hs.143102 5

copper ion binding

calcium ion binding

catecholamine metabolic process

visual perception

amine oxidase activity

electron carrier activity

amine metabolic process

oxidoreductase activity

quinone binding

oxidation reduction

Glycine, serine and threonine metabolism

Tyrosine metabolism

Phenylalanine metabolism

beta-Alanine metabolism

Isoquinoline alkaloid biosynthesis

Tropane, piperidine and pyridine alkaloid biosynthesis

Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid

Metabolic pathways

203069_at SV2A synaptic vesicle glycoprotein 2A 1 -148141499 NM_014849 1q21.2 Hs.516153 24

transporter activity

cytoplasm

endoplasmic reticulum

neurotransmitter transport

membrane

integral to membrane

cell junction

cytoplasmic vesicle

synapse

ECM-receptor interaction

208244_at -0.219 3.691 -2.345 3.299e-02 0.550 -3.561 BMP3 bone morphogenetic protein 3 4 82171142 NM_001201 4q21 Hs.387411 17

ossification

cytokine activity

extracellular region

extracellular space

cell-cell signaling

multicellular organismal development

growth factor activity

cell differentiation

positive regulation of transcription from RNA polymerase II promoter

cartilage development

 
226103_at NEXN nexilin (F actin binding protein) 1 78126787 AF114264 1p31.1 Hs.612385 6

cytoplasm

cytoskeleton

cell-substrate adherens junction

cell junction

regulation of cell migration

actin filament binding

regulation of cytoskeleton organization

 
239144_at 0.253 3.106 2.305 3.566e-02 0.556 -3.625 B3GAT2 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) 6 -71627789 AA835648 6q13 Hs.713609 9

Golgi apparatus

galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity

membrane

integral to membrane

carbohydrate biosynthetic process

transferase activity

manganese ion binding

metal ion binding

Chondroitin sulfate biosynthesis

Heparan sulfate biosynthesis

Metabolic pathways

1554067_at C12orf66 chromosome 12 open reading frame 66 12 -62872685 BC036246 12q14.2 Hs.505871 3    
211764_s_at -0.693 10.232 -2.451 2.679e-02 0.524 -3.387 UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 10 59764744 BC005980 10q11.2-q21 Hs.129683 54

nucleotide binding

protein polyubiquitination

ubiquitin-protein ligase activity

protein binding

ATP binding

nucleoplasm

cytosol

ubiquitin-dependent protein catabolic process

ligase activity

BMP signaling pathway

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein ubiquitination

post-translational protein modification

regulation of protein metabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Ubiquitin mediated proteolysis

239792_at LOC440288 similar to FLJ16518 protein 15   N75594 15q24.1 Hs.655532 1    
228463_at FOXA3 forkhead box A3 19 51059357 R99562 19q13.2-q13.4 Hs.36137 14

cellular glucose homeostasis

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

cellular response to starvation

sequence-specific DNA binding

Maturity onset diabetes of the young

225945_at 0.329 7.628 2.560 2.159e-02 0.497 -3.206 ZNF655 zinc finger protein 655 7 98993980, 98993980, 98994383, 98994383 BF219240 7q22.1 Hs.696221 12

DNA binding

protein binding

intracellular

nucleus

nucleolus

cytoplasm

regulation of mitotic cell cycle

zinc ion binding

regulation of transcription

metal ion binding

G1 phase

 
203487_s_at ARMC8 armadillo repeat containing 8 3 139388837, 139388837 NM_015396 3q22.3 Hs.719108 4

binding

 
218721_s_at C1orf27 chromosome 1 open reading frame 27 1 184611623 NM_017847 1q25 Hs.371210 6

zinc ion binding

membrane

integral to membrane

oxidoreductase activity

 
205148_s_at CLCN4 chloride channel 4 X 10084984 AA071195 Xp22.3 Hs.495674 17

nucleotide binding

ion channel activity

voltage-gated chloride channel activity

ATP binding

endosome

ion transport

chloride transport

antiporter activity

membrane

integral to membrane

chloride ion binding

 
204027_s_at 0.320 6.365 2.746 1.487e-02 0.453 -2.892 METTL1 methyltransferase like 1 12 -56448617 NM_005371 12q13 Hs.42957 10

tRNA binding

protein binding

nucleus

tRNA modification

methyltransferase activity

tRNA (guanine-N7-)-methyltransferase activity

transferase activity

 
225785_at REEP3 receptor accessory protein 3 10 64951128 BG112359 10q21.3 Hs.499833 7

membrane

integral to membrane

 
210538_s_at -0.363 3.460 -2.240 4.043e-02 0.570 -3.729 BIRC3 baculoviral IAP repeat-containing 3 11 101693403 U37546 11q22 Hs.127799 92

ubiquitin-protein ligase activity

protein binding

intracellular

nucleus

cytoplasm

anti-apoptosis

cell surface receptor linked signal transduction

zinc ion binding

regulation of apoptosis

metal ion binding

Ubiquitin mediated proteolysis

Apoptosis

Focal adhesion

Pathways in cancer

Small cell lung cancer

208853_s_at CANX calnexin 5 179058535 L18887 5q35 Hs.699155 90

calcium ion binding

sugar binding

endoplasmic reticulum

protein folding

protein secretion

membrane

integral to membrane

melanosome

unfolded protein binding

Antigen processing and presentation

234029_at PCDHGB8P protocadherin gamma subfamily B, 8 pseudogene 5 140786036 AF152529 5q31 Hs.672506 5    
221030_s_at ARHGAP24 Rho GTPase activating protein 24 4 86615307, 86918874, 87070449 NM_031305 4q21.23-q21.3 Hs.444229 14

angiogenesis

GTPase activator activity

protein binding

intracellular

cytoplasm

cytoskeleton

adherens junction

focal adhesion

signal transduction

multicellular organismal development

cell junction

cell differentiation

cell projection

 
212771_at 0.933 6.405 3.810 1.671e-03 0.263 -1.035 FAM171A1 family with sequence similarity 171, member A1 10 -15293649 AU150943 10p13 Hs.66762 4

membrane

integral to membrane

 
204042_at WASF3 WAS protein family, member 3 13 26029839 AB020707 13q12 Hs.635221 19

actin binding

cytoplasm

cytoskeleton

protein complex assembly

actin filament polymerization

Adherens junction

Fc gamma R-mediated phagocytosis

219196_at SCG3 secretogranin III 15 49760841 NM_013243 15q21 Hs.232618 16

extracellular region

 
241957_x_at LIN7B lin-7 homolog B (C. elegans) 19 54309429 AI686521 19q13.3 Hs.221737 15

protein binding

plasma membrane

tight junction

exocytosis

neurotransmitter secretion

protein transport

synaptosome

cell junction

synapse

postsynaptic membrane

 
226055_at ARRDC2 arrestin domain containing 2 19 17972943, 17979976 AK000689 19p13.11 Hs.515249 6    
232267_at 0.564 5.050 3.257 5.227e-03 0.348 -2.004 GPR133 G protein-coupled receptor 133 12 130004404 AL162032 12q24.33 Hs.719239 7

G-protein coupled receptor activity

G-protein coupled receptor activity

plasma membrane

neuropeptide signaling pathway

integral to membrane

integral to membrane

 
234035_at HNRNPM heterogeneous nuclear ribonucleoprotein M 19 8415802 AK022050 19p13.3-p13.2 Hs.465808 Hs.666214 28

nucleotide binding

nuclear mRNA splicing, via spliceosome

nuclear mRNA splicing, via spliceosome

RNA binding

nucleus

spliceosomal complex

nucleolus

integral to plasma membrane

RNA splicing

protein domain specific binding

 
212787_at YLPM1 YLP motif containing 1 14 74299821 AI952986 14q24.3 Hs.531111 11

molecular_function

cellular_component

nucleus

biological_process

nuclear speck

 
218677_at S100A14 S100 calcium binding protein A14 1 -151853355 NM_020672 1q21.3 Hs.288998 7

calcium ion binding

cytoplasm

 
208779_x_at 0.654 6.380 2.539 2.250e-02 0.500 -3.241 DDR1 discoidin domain receptor tyrosine kinase 1 6 30959839, 30960305, 30964443, 2300465, 2300931, 2305069, 2098794, 2099260, 2103398 L20817 6p21.3 Hs.631988 60

nucleotide binding

transmembrane receptor protein tyrosine kinase activity

receptor activity

protein binding

ATP binding

extracellular region

integral to plasma membrane

protein amino acid phosphorylation

cell adhesion

transmembrane receptor protein tyrosine kinase signaling pathway

membrane

transferase activity

 
201266_at TXNRD1 thioredoxin reductase 1 12 103133688, 103204856 NM_003330 12q23-q24.1 Hs.708065 60

thioredoxin-disulfide reductase activity

thioredoxin-disulfide reductase activity

nucleus

cytoplasm

cytosol

transport

signal transduction

selenium binding

electron carrier activity

protein disulfide oxidoreductase activity

oxidoreductase activity

electron transport chain

cell redox homeostasis

FAD binding

NADP or NADPH binding

Pyrimidine metabolism

1568877_a_at ACBD5 acyl-Coenzyme A binding domain containing 5 10 -27524149, -27524149 BC025309 10p12.1 Hs.530597 4

acyl-CoA binding

transport

lipid binding

membrane

integral to membrane

 
210418_s_at IDH3B isocitrate dehydrogenase 3 (NAD+) beta 20 -2587040 AF023265 20p13 Hs.436405 14

magnesium ion binding

isocitrate dehydrogenase (NAD+) activity

mitochondrion

mitochondrial matrix

tricarboxylic acid cycle

isocitrate metabolic process

visual perception

electron carrier activity

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

manganese ion binding

response to stimulus

NAD or NADH binding

oxidation reduction

Citrate cycle (TCA cycle)

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from shikimate pathway

Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

223615_at -0.295 6.230 -2.731 1.532e-02 0.457 -2.917 ABI3 ABI family, member 3 17 44642587 AL136709 17q21.3 Hs.130719 12

protein binding

intracellular

cytoplasm

cell motion

peptidyl-tyrosine phosphorylation

lamellipodium

regulation of cell migration

 
228490_at 0.518 3.485 2.773 1.408e-02 0.444 -2.846 ABHD2 abhydrolase domain containing 2 15 87432384 AW292816 15q26.1 Hs.122337 Hs.705984 10

molecular_function

carboxylesterase activity

biological_process

response to wounding

membrane

integral to membrane

hydrolase activity

negative regulation of cell migration

 
210605_s_at 0.424 6.486 3.792 1.733e-03 0.267 -1.066 MFGE8 milk fat globule-EGF factor 8 protein 15 -87242917 BC003610 15q25 Hs.3745 36

phosphatidylserine binding

integrin binding

protein binding

extracellular space

cytoplasm

phagocytosis, recognition

phagocytosis, engulfment

cell adhesion

single fertilization

phosphatidylethanolamine binding

external side of plasma membrane

membrane

extrinsic to plasma membrane

interspecies interaction between organisms

positive regulation of phagocytosis

 
1563632_at LOC220980 hypothetical protein LOC220980 10   AK056518 10q11.21 Hs.645270 1    
205541_s_at 0.573 6.321 2.472 2.572e-02 0.517 -3.353 GSPT2 G1 to S phase transition 2 X 51503236 NM_018094 Xp11.22 Hs.59523 10

nucleotide binding

translation release factor activity

GTPase activity

protein binding

protein binding

GTP binding

cytoplasm

translation

cell cycle

 
823_at CX3CL1 chemokine (C-X3-C motif) ligand 1 16 55963914 U84487 16q13 Hs.531668 100

extracellular region

extracellular space

plasma membrane

chemotaxis

defense response

immune response

cell adhesion

chemokine activity

cell surface

integral to membrane

cytokine-mediated signaling pathway

leukocyte chemotaxis

positive regulation of inflammatory response

leukocyte adhesive activation

positive regulation of calcium-independent cell-cell adhesion

Cytokine-cytokine receptor interaction

Chemokine signaling pathway

211136_s_at 0.249 5.855 2.785 1.372e-02 0.440 -2.824 CLPTM1 cleft lip and palate associated transmembrane protein 1 19 50150477 BC004865 19q13.2-q13.3 Hs.444441 12

integral to plasma membrane

multicellular organismal development

external side of plasma membrane

membrane

cell differentiation

regulation of T cell differentiation in the thymus

 
228725_x_at 0.510 6.179 4.440 4.623e-04 0.193 0.048 PRMT2 protein arginine methyltransferase 2 21 46879954 BF003112 21q22.3 Hs.154163 17

signal transducer activity

nucleus

protein amino acid methylation

signal transduction

methyltransferase activity

transferase activity

identical protein binding

 
217976_s_at 0.360 7.682 2.348 3.277e-02 0.550 -3.555 DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 3 -32542470 NM_016141 3p22.3 Hs.529495 11

nucleotide binding

motor activity

ATP binding

microtubule

dynein complex

 
201885_s_at CYB5R3 cytochrome b5 reductase 3 22 -41344757, -41344757 NM_000398 22q13.2-q13.31 22q13.31-qter Hs.700572 49

cytochrome-b5 reductase activity

cytoplasm

mitochondrion

mitochondrial outer membrane

mitochondrial inner membrane

endoplasmic reticulum

endoplasmic reticulum membrane

hemoglobin complex

cholesterol biosynthetic process

blood circulation

electron carrier activity

membrane

oxidoreductase activity

oxidation reduction

Amino sugar and nucleotide sugar metabolism

223212_at 0.462 7.546 3.583 2.669e-03 0.290 -1.432 ZDHHC16 zinc finger, DHHC-type containing 16 10 99195919, 99195936 BC004535 10q24.1 Hs.76662 6

endoplasmic reticulum

apoptosis

zinc ion binding

acyltransferase activity

membrane

integral to membrane

transferase activity

metal ion binding

 
232936_at KCNA7 potassium voltage-gated channel, shaker-related subfamily, member 7 19 -54262486 AJ310479 19q13.3 Hs.306973 5

voltage-gated ion channel activity

voltage-gated potassium channel activity

protein binding

ion transport

potassium ion transport

voltage-gated potassium channel complex

membrane

integral to membrane

potassium ion binding

 
221724_s_at CLEC4A C-type lectin domain family 4, member A 12 8167494 AF200738 12p13 Hs.504657 15

transmembrane receptor activity

binding

sugar binding

integral to plasma membrane

immune response

cell adhesion

cell surface receptor linked signal transduction

membrane

 
227512_at MEX3A mex-3 homolog A (C. elegans) 1 -154308427 AW248508 1q22 Hs.591496 3

cytoplasmic mRNA processing body

RNA binding

protein binding

nucleus

cytoplasm

zinc ion binding

metal ion binding

 
229770_at 0.709 6.353 4.134 8.595e-04 0.217 -0.473 GLT1D1 glycosyltransferase 1 domain containing 1 12 127904033 AI041543 12q24.33 Hs.655668 6

extracellular region

biosynthetic process

transferase activity, transferring glycosyl groups

 
1562903_at -0.655 4.554 -3.997 1.138e-03 0.230 -0.709 hCG_1990547 family with sequence similarity 86, member A pseudogene 8 8123501, 8123501, 8123501 BC035792 8p23.1 Hs.656318 2    
221082_s_at NDRG3 NDRG family member 3 20 -34713582 NM_022477 20q11.21-q11.23 Hs.437338 9

molecular_function

cytoplasm

spermatogenesis

cell differentiation

negative regulation of cell growth

 
219874_at -0.300 4.129 -2.697 1.641e-02 0.464 -2.975 SLC12A8 solute carrier family 12 (potassium/chloride transporters), member 8 3 -126284169 NM_024628 3q21.2 Hs.658514 7

ion transport

potassium ion transport

symporter activity

membrane

integral to membrane

potassium ion binding

chloride ion binding

 
225059_at AGTRAP angiotensin II receptor-associated protein 1 11718728 BE875567 1p36.22 Hs.464438 14

protein binding

endoplasmic reticulum

Golgi apparatus

membrane

integral to membrane

cytoplasmic vesicle

 
223347_at MUM1 melanoma associated antigen (mutated) 1 19 1305975, 1307322 AL360266 19p13.3 Hs.515016 6    
206734_at JRKL jerky homolog-like (mouse) 11 95762805 NM_003772 11q21 Hs.105940 4

DNA binding

nucleus

central nervous system development

regulation of transcription

 
237765_at C14orf68 chromosome 14 open reading frame 68 14 99859431 AA677293 14q32.2 Hs.108268 4

transporter activity

binding

mitochondrion

mitochondrial inner membrane

transport

membrane

integral to membrane

 
1556377_s_at 0.688 5.956 3.675 2.205e-03 0.276 -1.270 LMO7 LIM domain 7 13 75092570, 75232797 AF174600 13q22.2 Hs.207631 18

ubiquitin ligase complex

ubiquitin-protein ligase activity

protein binding

nucleus

cytoplasm

zinc ion binding

protein ubiquitination

metal ion binding

Adherens junction

208414_s_at HOXB3 homeobox B3 17 -43981230 NM_002146 17q21.3 Hs.654560 21

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

anterior/posterior pattern formation

glossopharyngeal nerve morphogenesis

thyroid gland development

sequence-specific DNA binding

embryonic skeletal system morphogenesis

cartilage development

definitive hemopoiesis

 
211447_s_at PDE4A phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) 19 10392332, 10402520, 10404110, 10424632 U18088 19p13.2 Hs.89901 32

3',5'-cyclic-AMP phosphodiesterase activity

membrane fraction

soluble fraction

signal transduction

membrane

hydrolase activity

Purine metabolism

204496_at STRN3 striatin, calmodulin binding protein 3 14 -30432755 NM_014574 14q13-q21 Hs.21016 Hs.401843 13

calmodulin binding

membrane fraction

nucleus

cytoplasm

cytosol

cell cycle

membrane

 
203396_at PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 15 76619801 NM_002789 15q25.1 Hs.251531 47

threonine-type endopeptidase activity

nucleus

cytoplasm

cytosol

proteasome core complex

ubiquitin-dependent protein catabolic process

peptidase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

identical protein binding

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

proteolysis involved in cellular protein catabolic process

Proteasome

241481_at FAM81A family with sequence similarity 81, member A 15 57517663 BF448365 15q22.2 Hs.659778 2    
205332_at RCE1 RCE1 homolog, prenyl protein peptidase (S. cerevisiae) 11 66367458 AF121951 11q13 Hs.654972 9

metalloendopeptidase activity

endoplasmic reticulum

integral to plasma membrane

proteolysis

membrane

hydrolase activity

 
201087_at PXN paxillin 12 -119132632, -119132632 NM_002859 12q24.31 Hs.446336 140

protein binding

cytoplasm

cytoskeleton

microtubule associated complex

plasma membrane

focal adhesion

cell adhesion

cell-matrix adhesion

signal transduction

signal complex assembly

zinc ion binding

vinculin binding

lamellipodium

cell junction

cellular response to reactive oxygen species

metal ion binding

Chemokine signaling pathway

VEGF signaling pathway

Focal adhesion

Leukocyte transendothelial migration

Regulation of actin cytoskeleton

226713_at 0.376 6.527 3.509 3.109e-03 0.303 -1.562 CCDC50 coiled-coil domain containing 50 3 192529567 AI247881 3q28 Hs.478682 12

protein binding

cytoplasm

 
1556474_a_at 0.257 2.496 2.360 3.206e-02 0.545 -3.537 FLJ38379 hypothetical FLJ38379 2   AK095698 2q37.3 Hs.653239 1    
201416_at SOX4 SRY (sex determining region Y)-box 4 6 21701950 BG528420 6p22.3 Hs.643910 35

pro-B cell differentiation

transcription factor activity

protein binding

nucleus

cytoplasm

heart development

positive regulation of cell proliferation

positive regulation of Wnt receptor signaling pathway

T cell differentiation

exocrine pancreas development

positive regulation of apoptosis

negative regulation of apoptosis

positive regulation of transcription, DNA-dependent

protein stabilization

Wnt receptor signaling pathway through beta-catenin

 
218239_s_at GTPBP4 GTP binding protein 4 10 1024348 NM_012341 10p15-p14 Hs.215766 10

regulation of cyclin-dependent protein kinase activity

nucleotide binding

GTPase activity

protein binding

GTP binding

nucleus

nucleolus

cytoplasm

negative regulation of DNA replication

negative regulation of cell proliferation

negative regulation of cell-cell adhesion

negative regulation of cell migration

negative regulation of protein ubiquitination

negative regulation of collagen binding

ribosome biogenesis

perinuclear region of cytoplasm

protein stabilization

 
228628_at -0.373 6.516 -2.608 1.960e-02 0.491 -3.125 SRGAP2P1 SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1 1   AI478268 1p11.2 Hs.523529 Hs.698027 2    
226327_at ZNF507 zinc finger protein 507 19 37528353 N64593 19q13.11 Hs.205392 5

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
240486_at -0.263 4.261 -3.159 6.388e-03 0.364 -2.175 HELZ helicase with zinc finger 17 -62497015 AA761673 17q24.2 Hs.370140 Hs.569824 Hs.596366 8

nucleotide binding

nucleic acid binding

helicase activity

ATP binding

nucleus

zinc ion binding

hydrolase activity

metal ion binding

 
1554188_at -0.240 5.927 -2.568 2.122e-02 0.497 -3.192 C11orf53 chromosome 11 open reading frame 53 11 110631916 BC039669 11q23.1 Hs.298685 3    
225738_at RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 9 -133441977, -133441977 AA761259 9q34.3 Hs.127897 46

guanyl-nucleotide exchange factor activity

protein binding

intracellular

endosome

cytosol

transmembrane receptor protein tyrosine kinase signaling pathway

SH3 domain binding

regulation of small GTPase mediated signal transduction

Focal adhesion

Neurotrophin signaling pathway

Insulin signaling pathway

Renal cell carcinoma

225339_at SPAG9 sperm associated antigen 9 17 -46394534 BG290577 17q21.33 Hs.463439 22

acrosomal vesicle

protein binding

cytoplasm

spermatogenesis

integral to membrane

positive regulation of cell migration

perinuclear region of cytoplasm

 
204607_at HMGCS2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) 1 -120092525 NM_005518 1p13-p12 Hs.59889 13

hydroxymethylglutaryl-CoA synthase activity

hydroxymethylglutaryl-CoA synthase activity

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

cholesterol biosynthetic process

response to nutrient

metabolic process

isoprenoid biosynthetic process

transferase activity

response to drug

response to peptide hormone stimulus

Synthesis and degradation of ketone bodies

Valine, leucine and isoleucine degradation

Butanoate metabolism

Terpenoid backbone biosynthesis

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

PPAR signaling pathway

205846_at PTPRB protein tyrosine phosphatase, receptor type, B 12 -69196898, -69196898 NM_002837 12q15-q21 Hs.434375 29

transmembrane receptor protein tyrosine phosphatase activity

protein binding

integral to plasma membrane

protein amino acid dephosphorylation

membrane

hydrolase activity

Adherens junction

224654_at 0.252 8.166 2.206 4.320e-02 0.577 -3.784 DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 10 70385897 BG164358 10q21 Hs.223141 Hs.576875 18

nucleotide binding

RNA binding

ATP-dependent RNA helicase activity

helicase activity

protein binding

ATP binding

nucleus

nucleolus

hydrolase activity

 
1552853_at VWA5B1 von Willebrand factor A domain containing 5B1 1 20489998 NM_144623 1p36.12 Hs.205178 3

extracellular region

 
217912_at 0.294 8.380 2.476 2.551e-02 0.516 -3.346 DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 17 -77609039 NM_022156 17q25.3 Hs.514599 2

tRNA processing

oxidoreductase activity

tRNA dihydrouridine synthase activity

FAD binding

oxidation reduction

 
205931_s_at CREB5 cAMP responsive element binding protein 5 7 28305464, 28418668, 28441758, 28692245 NM_004904 7p15.1 Hs.437075 10

transcription factor activity

intracellular

nucleus

transcription from RNA polymerase II promoter

zinc ion binding

sequence-specific DNA binding

positive regulation of transcription, DNA-dependent

metal ion binding

protein dimerization activity

Huntington's disease

Prostate cancer

218143_s_at SCAMP2 secretory carrier membrane protein 2 15 -72924249 NM_005697 15q23-q25 Hs.458917 12

protein binding

endosome

Golgi apparatus

post-Golgi vesicle-mediated transport

protein transport

membrane

integral to membrane

trans-Golgi network membrane

recycling endosome membrane

 
226734_at EIF4E2 eukaryotic translation initiation factor 4E family member 2 2 233123600 AW242220 2q37.1 Hs.292026 Hs.700929 15

RNA cap binding

translation initiation factor activity

protein binding

cytoplasm

translational initiation

regulation of translation

mTOR signaling pathway

Insulin signaling pathway

211174_s_at -0.291 4.438 -2.147 4.835e-02 0.589 -3.876 CCKAR cholecystokinin A receptor 4 -26092115 L13605 4p15.1-p15.2 Hs.129 50

neuron migration

receptor activity

G-protein coupled receptor activity

cholecystokinin receptor activity

plasma membrane

integral to plasma membrane

signal transduction

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

elevation of cytosolic calcium ion concentration

axonogenesis

response to nutrient

digestion

feeding behavior

forebrain development

Calcium signaling pathway

Neuroactive ligand-receptor interaction

224818_at SORT1 sortilin 1 1 -109653714 BE622952 1p21.3-p13.1 Hs.485195 Hs.703487 47

ossification

receptor activity

nucleus

lysosome

early endosome

endoplasmic reticulum

microsome

Golgi apparatus

plasma membrane

coated pit

transport

Golgi to endosome transport

endocytosis

neuropeptide signaling pathway

multicellular organismal development

endosome to lysosome transport

induction of apoptosis by extracellular signals

cell surface

nerve growth factor receptor activity

regulation of gene expression

myotube differentiation

integral to membrane

cytoplasmic membrane-bounded vesicle

vesicle organization

enzyme binding

clathrin-coated vesicle

cell differentiation

neurotensin receptor activity, non-G-protein coupled

endosome transport via multivesicular body sorting pathway

response to insulin stimulus

negative regulation of apoptosis

glucose import

nerve growth factor receptor signaling pathway

plasma membrane to endosome transport

nerve growth factor binding

perinuclear region of cytoplasm

negative regulation of lipoprotein lipase activity

Lysosome

Neurotrophin signaling pathway

217946_s_at 0.490 7.029 2.709 1.602e-02 0.459 -2.955 SAE1 SUMO1 activating enzyme subunit 1 19 52325919, 52325954, 52325971 NM_016402 19q13.32 Hs.515500 20

ubiquitin activating enzyme activity

nucleus

protein modification process

protein C-terminus binding

protein C-terminus binding

enzyme activator activity

metabolic process

protein ubiquitination

ligase activity

modification-dependent protein catabolic process

ATP-dependent protein binding

protein heterodimerization activity

Ubiquitin mediated proteolysis

219918_s_at ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 1 -195319879 NM_018123 1q31 Hs.121028 35

calmodulin binding

nucleus

cytoplasm

cell cycle

mitosis

cell division

 
211839_s_at CSF1 colony stimulating factor 1 (macrophage) 1 110254755, 110254755, 110254755 U22386 1p21-p13 Hs.591402 123

positive regulation of cell-matrix adhesion

reproductive developmental process

cytokine activity

macrophage colony stimulating factor receptor binding

extracellular region

extracellular space

plasma membrane

positive regulation of cell proliferation

positive regulation of gene expression

positive regulation of foam cell differentiation

integral to membrane

hemopoiesis

cell differentiation

positive regulation of cell migration

positive regulation of cellular protein metabolic process

positive regulation of mononuclear cell proliferation

monocyte activation

protein homodimerization activity

receptor complex

positive regulation of monocyte differentiation

positive regulation of protein kinase activity

perinuclear region of cytoplasm

Cytokine-cytokine receptor interaction

Hematopoietic cell lineage

213859_x_at SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 4 144654065 AI652586 4q31.1-q31.2 Hs.558422 Hs.710623 37

nucleotide binding

condensed chromosome

DNA binding

RNA polymerase II transcription factor activity

helicase activity

ATP binding

nucleus

nucleoplasm

nucleolus

chromatin assembly or disassembly

nucleosome assembly

transcription initiation

regulation of transcription from RNA polymerase II promoter

embryonic development

transcription activator activity

nucleosome positioning

hydrolase activity

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ATPase activity

RSF complex

nucleosome binding

histone binding

ATP-dependent chromatin remodeling

 
1555620_a_at -0.304 6.581 -3.539 2.919e-03 0.298 -1.509 PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 19 -51815564 BC017857 19q13.3 Hs.458324 55

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein signaling, coupled to cyclic nucleotide second messenger

cell-cell signaling

Neuroactive ligand-receptor interaction

Vascular smooth muscle contraction

223831_x_at ISY1 ISY1 splicing factor homolog (S. cerevisiae) 3 -130330924 BC004442 3q21.3 Hs.512661 7

nucleus

spliceosomal complex

nucleolus

cytoplasm

mRNA processing

RNA splicing

 
215695_s_at GYG2 glycogenin 2 X 2756862 U94357 Xp22.3 Hs.567381 Hs.701629 13

soluble fraction

cytosol

glycogen biosynthetic process

glycogenin glucosyltransferase activity

glycogenin glucosyltransferase activity

transferase activity, transferring glycosyl groups

 
206319_s_at SPINLW1 serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin) 20 -43602678, -43602678 AF286368 20q12-q13.2 Hs.121084 10

serine-type endopeptidase inhibitor activity

extracellular region

peptidase inhibitor activity

 
219737_s_at PCDH9 protocadherin 9 13 -65774967 AI524125 13q14.3-q21.1 Hs.654709 Hs.719302 8

calcium ion binding

protein binding

plasma membrane

cell adhesion

homophilic cell adhesion

integral to membrane

 
220545_s_at TSKS testis-specific serine kinase substrate 19 -54934822 NM_021733 19q13.3 Hs.515858 6

protein binding

 
208374_s_at CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 1 112963597 NM_006135 1p13.2 Hs.514934 21

actin binding

protein binding

protein complex assembly

cell motion

F-actin capping protein complex

actin cytoskeleton organization

actin filament capping

 
203804_s_at LUC7L3 LUC7-like 3 (S. cerevisiae) 17 46151975 NM_006107 17q21.33 Hs.130293 15

DNA binding

mRNA binding

protein binding

nucleus

mRNA processing

apoptosis

response to stress

RNA splicing

nuclear speck

 
225001_at RAB3D RAB3D, member RAS oncogene family 19 -11296092 AI744658 19p13.2 Hs.655274 13

nucleotide binding

GTPase activity

protein binding

GTP binding

plasma membrane

exocytosis

small GTPase mediated signal transduction

protein transport

 
209944_at ZNF410 zinc finger protein 410 14 73423338 BC000330 14q24.3 Hs.270869 9

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
209405_s_at FAM3A family with sequence similarity 3, member A X -153387699 BC002934 Xq28 Hs.289108 7

molecular_function

extracellular region

biological_process

 
212992_at 0.323 3.712 2.570 2.117e-02 0.497 -3.190 AHNAK2 AHNAK nucleoprotein 2 14 -104474635 AI935123 14q32.33 Hs.441783 3

protein binding

nucleus

cytoplasm

keratinization

 
212846_at RRP1B ribosomal RNA processing 1 homolog B (S. cerevisiae) 21 43903859 AA811192 21q22.3 Hs.654727 14

protein binding

nucleus

nucleolus

cytosol

rRNA processing

preribosome, small subunit precursor

 
221931_s_at SEH1L SEH1-like (S. cerevisiae) 18 12937982 AV701173 18p11.21 Hs.301048 9

kinetochore

nucleus

nuclear pore organization

mitotic metaphase plate congression

protein transport

Nup107-160 complex

Nup107-160 complex

mRNA transport

attachment of spindle microtubules to kinetochore during mitosis

intracellular protein transmembrane transport

 
211803_at CDK2 cyclin-dependent kinase 2 12 54646822 AB012305 12q13 Hs.19192 Hs.689624 306

G2/M transition of mitotic cell cycle

nucleotide binding

cyclin-dependent protein kinase holoenzyme complex

cyclin-dependent protein kinase activity

cyclin-dependent protein kinase activity

ATP binding

nucleus

nucleoplasm

cytoplasm

cytosol

regulation of DNA replication

protein amino acid phosphorylation

cell cycle

mitosis

traversing start control point of mitotic cell cycle

positive regulation of cell proliferation

transferase activity

histone kinase activity

identical protein binding

cell division

Cell cycle

p53 signaling pathway

Pathways in cancer

Prostate cancer

Small cell lung cancer

220935_s_at 0.317 6.696 2.825 1.266e-02 0.429 -2.756 CDK5RAP2 CDK5 regulatory subunit associated protein 2 9 -122190967 NM_018249 9q33.2 Hs.269560 18

centrosome

cytoskeleton

brain development

microtubule binding

neuronal Cdc2-like kinase binding

regulation of neuron differentiation

 
212275_s_at SRCAP Snf2-related CREBBP activator protein 16 30617962 NM_006662 16p11.2 Hs.647334 16

nucleotide binding

DNA binding

transcription coactivator activity

helicase activity

histone acetyltransferase activity

ATP binding

nucleus

regulation of transcription from RNA polymerase II promoter

chromatin modification

hydrolase activity

protein complex

interspecies interaction between organisms

regulation of transcription

 
213421_x_at -0.306 5.154 -2.896 1.096e-02 0.424 -2.634 PRSS3 protease, serine, 3 9 33740514, 33785558 AW007273 9p11.2 Hs.654513 22

serine-type endopeptidase activity

calcium ion binding

protein binding

extracellular region

extracellular space

proteolysis

proteolysis

digestion

peptidase activity

zymogen activation

endothelial cell migration

Neuroactive ligand-receptor interaction

206277_at P2RY2 purinergic receptor P2Y, G-protein coupled, 2 11 72606991, 72607149 NM_002564 11q13.5-q14.1 Hs.339 43

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

cellular ion homeostasis

signal transduction

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

purinergic nucleotide receptor activity, G-protein coupled

Neuroactive ligand-receptor interaction

1562299_at -0.236 3.018 -2.795 1.346e-02 0.437 -2.808 C14orf25 chromosome 14 open reading frame 25 14   BC038110 14q21.1 Hs.659936 2    
1560874_at EFCAB4B EF-hand calcium binding domain 4B 12 -3627369, -3619818, -3594754 AK057608 12p13.32 Hs.504534 Hs.719531 6

calcium ion binding

 
228409_at -0.343 8.084 -2.135 4.939e-02 0.590 -3.894 PLIN4 perilipin 4 19 -4453191 T62068 19p13.3 Hs.591387 4

cytoplasm

plasma membrane

monolayer-surrounded lipid storage body

 
212814_at AHCYL2 adenosylhomocysteinase-like 2 7 128652099, 128795217 AB020635 7q32.1 Hs.600789 5

adenosylhomocysteinase activity

binding

one-carbon metabolic process

metabolic process

hydrolase activity

Cysteine and methionine metabolism

Selenoamino acid metabolism

Metabolic pathways

211603_s_at ETV4 ets variant 4 17 -38960736, -38960736 U35622 17q21 Hs.434059 48

transcription factor activity

nucleus

nucleolus

regulation of transcription, DNA-dependent

motor axon guidance

organ morphogenesis

transcription activator activity

sequence-specific DNA binding

positive regulation of transcription

 
218579_s_at 0.269 4.886 2.330 3.396e-02 0.552 -3.585 DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 20 37024413 NM_021931 20q11.22-q12 Hs.444520 5

nucleotide binding

nucleic acid binding

helicase activity

ATP binding

spliceosomal complex

mRNA processing

ATP-dependent helicase activity

RNA splicing

hydrolase activity

 
232803_at FLJ31958 hypothetical LOC143153 10   H09470 10q11.23 Hs.706372 1    
210014_x_at IDH3B isocitrate dehydrogenase 3 (NAD+) beta 20 -2587040 AF023266 20p13 Hs.436405 14

magnesium ion binding

isocitrate dehydrogenase (NAD+) activity

mitochondrion

mitochondrial matrix

tricarboxylic acid cycle

isocitrate metabolic process

visual perception

electron carrier activity

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

manganese ion binding

response to stimulus

NAD or NADH binding

oxidation reduction

Citrate cycle (TCA cycle)

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from shikimate pathway

Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

218488_at 0.177 9.280 2.218 4.218e-02 0.575 -3.764 EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 1 -45089036 NM_020365 1p34.1 Hs.533549 25

translation initiation factor activity

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

protein binding

cytoplasm

eukaryotic translation initiation factor 2B complex

translational initiation

biosynthetic process

response to heat

response to heat

response to glucose stimulus

oligodendrocyte development

transferase activity

nucleotidyltransferase activity

negative regulation of translational initiation in response to stress

response to peptide hormone stimulus

cellular response to stimulus

 
217485_x_at PMS2L1 postmeiotic segregation increased 2-like 1 pseudogene 7 -99756198 D38435 7q22.1 Hs.634244 Hs.661055 Hs.709266 7

molecular_function

ATP binding

cellular_component

mismatch repair

biological_process

kinase activity

transferase activity

mismatched DNA binding

 
217856_at 0.446 5.399 2.142 4.873e-02 0.590 -3.883 RBM8A RNA binding motif protein 8A 1 144218994 AF182415 1q12 Hs.356873 43

nucleotide binding

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nuclear mRNA splicing, via spliceosome

mRNA binding

protein binding

nucleus

spliceosomal complex

cytoplasm

transport

biological_process

RNA splicing

nuclear speck

exon-exon junction complex

mRNA transport

 
214934_at ATP9B ATPase, class II, type 9B 18 74930384 AW411030 18q23 Hs.465475 6

nucleotide binding

magnesium ion binding

phospholipid-translocating ATPase activity

ATP binding

ATP biosynthetic process

metabolic process

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

phospholipid transport

aminophospholipid transport

membrane

integral to membrane

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

cation-transporting ATPase activity

 
200682_s_at UBE2L3 ubiquitin-conjugating enzyme E2L 3 22 20251956 BG531983 22q11.21 Hs.108104 Hs.603229 Hs.715088 38

ubiquitin ligase complex

nucleotide binding

ubiquitin-protein ligase activity

ATP binding

cytoplasm

ubiquitin-dependent protein catabolic process

protein ubiquitination

ligase activity

enzyme binding

regulation of protein metabolic process

Ubiquitin mediated proteolysis

Parkinson's disease

224337_s_at FZD4 frizzled homolog 4 (Drosophila) 11 -86334368 AB054881 11q14.2 Hs.591968 25

non-G-protein coupled 7TM receptor activity

G-protein coupled receptor activity

protein binding

G-protein coupled receptor protein signaling pathway

multicellular organismal development

membrane

integral to membrane

Wnt receptor signaling pathway

Wnt receptor activity

Wnt signaling pathway

Melanogenesis

Pathways in cancer

Colorectal cancer

Basal cell carcinoma

235188_at C14orf135 chromosome 14 open reading frame 135 14 59628381 AI479328 14q23.1 Hs.509499 7

membrane

integral to membrane

 
224001_at -0.353 5.706 -2.912 1.061e-02 0.418 -2.607 FAM135B family with sequence similarity 135, member B 8 -139211447 AF131744 8q24.23 Hs.126024 5    
212820_at DMXL2 Dmx-like 2 15 -49527230 AB020663 15q21.2 Hs.511386 9

synaptic vesicle

membrane

Rab GTPase binding

cell junction

cytoplasmic vesicle

synapse

 
214439_x_at BIN1 bridging integrator 1 2 -127522077, -127522076 AF043899 2q14 Hs.193163 69

protein binding

nucleus

cytoplasm

multicellular organismal development

cell proliferation

actin cytoskeleton

regulation of endocytosis

cell differentiation

interspecies interaction between organisms

 
226015_at 0.359 6.752 3.504 3.141e-03 0.304 -1.571 ZNF12 zinc finger protein 12 7 -6694588 AI865669 7p22.1 Hs.431471 6

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
205745_x_at ADAM17 ADAM metallopeptidase domain 17 2 -9546861 NM_003183 2p25 Hs.404914 121

response to hypoxia

positive regulation of protein amino acid phosphorylation

neutrophil mediated immunity

germinal center formation

metalloendopeptidase activity

interleukin-6 receptor binding

integrin binding

protein binding

cytoplasm

integral to plasma membrane

cell-cell junction

focal adhesion

proteolysis

epidermal growth factor receptor signaling pathway

Notch signaling pathway

peptidase activity

zinc ion binding

positive regulation of cell proliferation

response to bacterium

cell surface

positive regulation of T cell chemotaxis

actin cytoskeleton

membrane

apical plasma membrane

SH3 domain binding

PDZ domain binding

B cell differentiation

positive regulation of cell growth

positive regulation of cell migration

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cyclin-dependent protein kinase activity during G1/S

response to lipopolysaccharide

ruffle membrane

negative regulation of interleukin-8 production

positive regulation of chemokine production

regulation of mast cell apoptosis

T cell differentiation in the thymus

cell adhesion mediated by integrin

wound healing, spreading of epidermal cells

response to drug

membrane raft

positive regulation of epidermal growth factor receptor activity

metal ion binding

spleen development

cell motility

PMA-inducible membrane protein ectodomain proteolysis

response to high density lipoprotein stimulus

Notch signaling pathway

Alzheimer's disease

Epithelial cell signaling in Helicobacter pylori infection

230486_at -0.310 5.833 -3.242 5.394e-03 0.352 -2.031 PCBP3 poly(rC) binding protein 3 21 46094302 BG025371 21q22.3 Hs.474049 11

DNA binding

RNA binding

nucleus

cytoplasm

cytosol

mRNA metabolic process

ribonucleoprotein complex

 
206029_at ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 10 -92661836 NM_014391 10q23.31 Hs.448589 19

DNA binding

transcription corepressor activity

protein binding

nucleus

transcription factor complex

cytoplasm

regulation of transcription from RNA polymerase II promoter

defense response

signal transduction

I band

 
216454_at TRMT1 TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae) 19 -13076713, -13076713 AL390133 19p13.2 Hs.515169 7

RNA binding

tRNA (guanine-N2-)-methyltransferase activity

tRNA processing

methyltransferase activity

zinc ion binding

transferase activity

metal ion binding

 
216348_at -0.279 7.452 -2.801 1.330e-02 0.435 -2.798 RPS17P5 ribosomal protein S17 pseudogene 5 6   AL049693 6p12.3   2    
226650_at 0.819 6.071 4.624 3.196e-04 0.179 0.356 ZFAND2A zinc finger, AN1-type domain 2A 7 -1159069 AI984061 7p22.3 Hs.648111 2

nucleus

cytoplasm

zinc ion binding

metal ion binding

 
222519_s_at IFT57 intraflagellar transport 57 homolog (Chlamydomonas) 3 -109362348 AW243004 3q13.12-q13.13 Hs.412196 13

DNA binding

protein binding

Golgi apparatus

cilium

microtubule basal body

activation of caspase activity

regulation of apoptosis

regulation of transcription

Huntington's disease

225519_at 0.359 7.838 2.241 4.039e-02 0.569 -3.728 PPP4R2 protein phosphatase 4, regulatory subunit 2 3 73128808 AA206408 3p13 Hs.431092 7

protein binding

centrosome

mRNA processing

protein modification process

RNA splicing

 
33850_at MAP4 microtubule-associated protein 4 3 -47989573, -47867183, -47867183 W28892 3p21 Hs.517949 40

structural molecule activity

protein binding

microtubule

microtubule associated complex

negative regulation of microtubule depolymerization

 
211769_x_at 0.468 7.546 2.144 4.859e-02 0.590 -3.880 SERINC3 serine incorporator 3 20 -42561314, -42558277 BC006088 20q13.1-q13.3 Hs.272168 Hs.696043 10

protein binding

Golgi apparatus

plasma membrane

induction of apoptosis

integral to membrane

 
211120_x_at ESR2 estrogen receptor 2 (ER beta) 14 -63769499, -63763503, -63763503 AB006590 14q23.2 Hs.525392 Hs.660607 488

transcription factor activity

transcription coactivator activity

steroid binding

protein binding

nucleus

mitochondrion

regulation of transcription, DNA-dependent

signal transduction

cell-cell signaling

zinc ion binding

estrogen receptor activity

negative regulation of cell growth

estrogen receptor signaling pathway

sequence-specific DNA binding

metal ion binding

receptor antagonist activity

 
235590_at FAM178A family with sequence similarity 178, member A 10 102662315, 102662315, 102662315 BF112155 10q24.31 Hs.447458 5    
206791_s_at PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) 19 -18179770, -18179770, -18179770 BF511742 19p13.11 Hs.132584 13

3',5'-cyclic-AMP phosphodiesterase activity

signal transduction

hydrolase activity

Purine metabolism

216347_s_at 0.272 6.265 2.567 2.131e-02 0.497 -3.195 PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B 14 -103269840 AK023188 14q32.33 Hs.709297 13

protein binding

nucleus

cytoplasm

apoptosis

induction of apoptosis

negative regulation of cell cycle

 
220239_at 0.468 4.141 2.343 3.312e-02 0.551 -3.564 KLHL7 kelch-like 7 (Drosophila) 7 23111877 NM_018846 7p15.3 Hs.654817 9

protein binding

nucleus

nucleolus

 
204958_at PLK3 polo-like kinase 3 (Drosophila) 1 45038622 NM_004073 1p34.1 Hs.632415 33

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

protein amino acid phosphorylation

cell cycle

membrane

transferase activity

dendrite

polo kinase kinase activity

 
208751_at NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 19 -52682702 BC001165 19q13.32-q13.33 Hs.126938 Hs.719083 27

protein binding

endoplasmic reticulum

Golgi apparatus

intracellular protein transport

intra-Golgi vesicle-mediated transport

membrane fusion

brain development

membrane

vesicle-mediated transport

syntaxin binding

neuron differentiation

apical protein localization

 
217943_s_at MAP7D1 MAP7 domain containing 1 1 36394389 NM_018067 1p34.3 Hs.700595 7

spindle

 
204001_at SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 9 15412781 NM_003084 9p22.3 Hs.546299 12

DNA binding

protein binding

nucleus

transcription from RNA polymerase II promoter

transcription from RNA polymerase III promoter

snRNA transcription

regulation of transcription

 
222617_s_at 0.431 7.394 2.336 3.359e-02 0.552 -3.576 C10orf84 chromosome 10 open reading frame 84 10 -120058561 AI147026 10q26.11 Hs.372309 5    
1552848_a_at -0.444 4.164 -3.403 3.869e-03 0.319 -1.748 PTCHD1 patched domain containing 1 X 23262905 NM_173495 Xp22.11 Hs.319503 2

hedgehog receptor activity

membrane

integral to membrane

 
206146_s_at RHAG Rh-associated glycoprotein 6 -49680848 AF178841 6p21.1-p11 Hs.120950 35

plasma membrane

plasma membrane

integral to plasma membrane

transport

cellular ion homeostasis

ammonium transmembrane transporter activity

ammonium transmembrane transporter activity

carbon dioxide transport

ammonium transport

ammonium transport

ankyrin binding

ammonia transporter activity

 
221325_at -0.250 4.524 -3.467 3.386e-03 0.308 -1.635 KCNK13 potassium channel, subfamily K, member 13 14 89597860 NM_022054 14q31-q32 Hs.510191 8

voltage-gated ion channel activity

potassium channel activity

ion transport

potassium ion transport

membrane

integral to membrane

potassium ion binding

 
1555083_at -0.204 6.198 -2.280 3.744e-02 0.563 -3.666 RPL13AP17 ribosomal protein L13a pseudogene 17 7 77814494 BC027852 7q21.11 Hs.568045 3    
1562495_at ANKFY1 ankyrin repeat and FYVE domain containing 1 17 -4044521, -4013413 BM970179 17p13.3 Hs.696087 11

protein binding

cytoplasm

endosome

zinc ion binding

endosome membrane

membrane

metal ion binding

 
220166_at CNNM1 cyclin M1 10 101078845 NM_020348 10q24.2 Hs.274579 5

plasma membrane

ion transport

integral to membrane

 
217011_at -0.314 5.787 -2.662 1.760e-02 0.473 -3.034 GBX1 gastrulation brain homeobox 1 7 -150476608 L11239 7q36 Hs.647114 4

nuclear chromosome

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

sequence-specific DNA binding

 
235918_x_at CEP97 centrosomal protein 97kDa 3 102926183 AL559474 3q12.3 Hs.444135 9

protein binding

cytoplasm

centrosome

 
201212_at LGMN legumain 14 -92239907 D55696 14q32.1 Hs.719135 17

cysteine-type endopeptidase activity

protein serine/threonine kinase activity

cytoplasm

lysosome

late endosome

proteolysis

peptidase activity

negative regulation of multicellular organism growth

intracellular membrane-bounded organelle

apical part of cell

Lysosome

Antigen processing and presentation

219281_at 0.461 7.662 2.725 1.550e-02 0.458 -2.927 MSRA methionine sulfoxide reductase A 8 9949239, 9990475 NM_012331 8p23.1 Hs.490981 22

protein modification process

methionine metabolic process

response to oxidative stress

peptide-methionine-(S)-S-oxide reductase activity

oxidoreductase activity

protein metabolic process

oxidation reduction

 
214553_s_at ARPP19 cAMP-regulated phosphoprotein, 19kDa 15 -50626723 NM_006628 15q21.2 Hs.512908 10

receptor binding

cytoplasm

potassium channel regulator activity

positive regulation of gluconeogenesis

positive regulation of glucose import

 
201986_at MED13 mediator complex subunit 13 17 -57374747 AB011165 17q22-q23 Hs.282678 26

receptor activity

nucleus

transcription initiation from RNA polymerase II promoter

RNA polymerase II transcription mediator activity

ligand-dependent nuclear receptor transcription coactivator activity

androgen receptor signaling pathway

vitamin D receptor binding

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

thyroid hormone receptor binding

 
202582_s_at RANBP9 RAN binding protein 9 6 -13729708 AF306510 6p23 Hs.708182 37

nucleus

cytoplasm

microtubule associated complex

protein complex assembly

microtubule nucleation

Ran GTPase binding

enzyme binding

 
235684_s_at SESN3 sestrin 3 11 -94545780 BF685808 11q21 Hs.659934 4

nucleus

cell cycle arrest

p53 signaling pathway

232977_x_at MYH14 myosin, heavy chain 14 19 55398696 BC004396 19q13.33 Hs.467142 19

nucleotide binding

motor activity

actin binding

calmodulin binding

ATP binding

regulation of cell shape

myosin complex

Tight junction

Regulation of actin cytoskeleton

207093_s_at -0.244 5.278 -2.180 4.541e-02 0.581 -3.825 OMG oligodendrocyte myelin glycoprotein 17 -26645794 NM_002544 17q11.2 Hs.113874 16

protein binding

plasma membrane

cell adhesion

anchored to membrane

 
60815_at POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene 7 -43947018 AA601208 7p13 Hs.657028 5    
238528_at UBR1 ubiquitin protein ligase E3 component n-recognin 1 15 -41022389 AI361043 15q13 Hs.591121 21

ubiquitin ligase complex

proteasome complex

ubiquitin-protein ligase activity

protein binding

cytoplasm

cytosol

ubiquitin-dependent protein catabolic process

zinc ion binding

ligase activity

protein catabolic process

metal ion binding

 
214369_s_at RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 11 -64250958, -64250958, -64250958 AI688812 11q13 Hs.99491 11

regulation of cell growth

guanyl-nucleotide exchange factor activity

calcium ion binding

calcium ion binding

intracellular

cytoplasm

cytosol

plasma membrane

Ras protein signal transduction

zinc ion binding

synaptosome

diacylglycerol binding

cell junction

cell projection

synapse

regulation of small GTPase mediated signal transduction

MAPK signaling pathway

Chemokine signaling pathway

209682_at 0.576 6.375 3.812 1.663e-03 0.263 -1.031 CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 3 -106859798 U26710 3q13.11 Hs.430589 44

signal transducer activity

calcium ion binding

protein binding

nucleus

cytoplasm

NLS-bearing substrate import into nucleus

immune response

cell surface receptor linked signal transduction

zinc ion binding

ligase activity

modification-dependent protein catabolic process

ErbB signaling pathway

Ubiquitin mediated proteolysis

Endocytosis

Jak-STAT signaling pathway

T cell receptor signaling pathway

Insulin signaling pathway

Pathways in cancer

Chronic myeloid leukemia

204209_at PCYT1A phosphate cytidylyltransferase 1, choline, alpha 3 -197449649 AI638771 3q29 Hs.435767 15

choline-phosphate cytidylyltransferase activity

soluble fraction

cytoplasm

endoplasmic reticulum membrane

cytosol

phosphatidylcholine biosynthetic process

phospholipid biosynthetic process

biosynthetic process

response to abiotic stimulus

membrane

transferase activity

nucleotidyltransferase activity

glycogen granule

Aminophosphonate metabolism

Glycerophospholipid metabolism

Metabolic pathways

1555971_s_at FBXO28 F-box protein 28 1 222368413 AU154086 1q42.11 Hs.64691 Hs.713992 10

modification-dependent protein catabolic process

 
240409_at SUGT1L1 SGT1, suppressor of G2 allele of SKP1 like 1 (S. cerevisiae) 13 -40269126 AI203405 13q14.11 Hs.442781 Hs.709973 2    
1561892_at ZMYM6 zinc finger, MYM-type 6 1 -35224353 BC043174 1p34.2 Hs.533986 Hs.623978 Hs.675613 8

DNA binding

nucleus

nucleolus

multicellular organismal development

zinc ion binding

metal ion binding

 
217730_at TMBIM1 transmembrane BAX inhibitor motif containing 1 2 -218847160 NM_022152 2p24.3-p24.1 Hs.591605 9

membrane

integral to membrane

 
224574_at C17orf49 chromosome 17 open reading frame 49 17 6858796 AV759602 17p13.1 Hs.511801 7

DNA binding

nucleus

 
91684_g_at 0.347 6.190 2.487 2.494e-02 0.513 -3.327 EXOSC4 exosome component 4 8 145205509 AI571298 8q24.3 Hs.632041 16

3'-5'-exoribonuclease activity

exosome (RNase complex)

RNA binding

exonuclease activity

protein binding

nucleus

nucleolus

cytoplasm

rRNA processing

RNA processing

hydrolase activity

RNA degradation

203004_s_at MEF2D myocyte enhancer factor 2D 1 -154700142 NM_005920 1q12-q23 Hs.314327 35

transcription factor activity

nucleus

nucleolus

cytoplasm

regulation of transcription, DNA-dependent

apoptosis

multicellular organismal development

nervous system development

muscle organ development

cell differentiation

sequence-specific DNA binding

 
201841_s_at HSPB1 heat shock 27kDa protein 1 7 75769810 NM_001540 7q11.23 Hs.520973 153

nucleus

cytoplasm

spindle

cytoskeleton

regulation of translational initiation

anti-apoptosis

cell motion

response to unfolded protein

cell death

response to heat

cell surface

identical protein binding

MAPK signaling pathway

VEGF signaling pathway

225843_at ZFYVE19 zinc finger, FYVE domain containing 19 15 38886565 AW015263 15q15.1 Hs.121676 8

protein binding

zinc ion binding

metal ion binding

 
208652_at 0.362 9.460 2.529 2.297e-02 0.503 -3.258 PPP2CA protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 5 -133560046 BC000400 5q31.1 Hs.105818 105

protein phosphatase type 2A complex

inactivation of MAPK activity

chromosome, centromeric region

phosphoprotein phosphatase activity

iron ion binding

protein binding

soluble fraction

nucleus

cytoplasm

mitochondrion

spindle

cytosol

plasma membrane

regulation of DNA replication

protein amino acid dephosphorylation

ceramide metabolic process

induction of apoptosis

mesoderm development

RNA splicing

response to organic substance

hydrolase activity

second-messenger-mediated signaling

regulation of Wnt receptor signaling pathway

manganese ion binding

regulation of cell adhesion

negative regulation of cell growth

regulation of growth

negative regulation of tyrosine phosphorylation of Stat3 protein

regulation of transcription

regulation of cell differentiation

metal ion binding

protein heterodimerization activity

Wnt signaling pathway

TGF-beta signaling pathway

Tight junction

Long-term depression

211684_s_at 0.341 8.353 2.836 1.239e-02 0.427 -2.738 DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2 172252227 AF250307 2q31.1 Hs.546250 17

microtubule motor activity

protein binding

cytoplasm

microtubule

microtubule-based movement

dynein complex

 
213092_x_at DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 10 -74672587 AW241779 10q22.2 Hs.654694 4

heat shock protein binding

 
201156_s_at RAB5C RAB5C, member RAS oncogene family 17 -37530522 AF141304 17q21.2 Hs.650382 11

nucleotide binding

GTPase activity

protein binding

GTP binding

endosome

plasma membrane

endosome organization

small GTPase mediated signal transduction

protein transport

regulation of endocytosis

endocytic vesicle

melanosome

Endocytosis

205219_s_at GALK2 galactokinase 2 15 47235267, 47249713 NM_002044 15q21.1-q21.2 Hs.122006 Hs.712959 8

nucleotide binding

galactokinase activity

ATP binding

cytoplasm

carbohydrate metabolic process

galactose metabolic process

metabolic process

kinase activity

transferase activity

N-acetylgalactosamine kinase activity

carbohydrate phosphorylation

Galactose metabolism

Amino sugar and nucleotide sugar metabolism

Metabolic pathways

204009_s_at 0.387 7.833 2.238 4.062e-02 0.570 -3.733 KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 12 -25249446 W80678 12p12.1 Hs.505033 430

nucleotide binding

protein binding

GTP binding

intracellular

membrane fraction

plasma membrane

plasma membrane

endocytosis

Ras protein signal transduction

cell aging

positive regulation of cell proliferation

visual learning

actin cytoskeleton organization

regulation of synaptic transmission, GABAergic

positive regulation of Rac protein signal transduction

negative regulation of neuron apoptosis

regulation of long-term neuronal synaptic plasticity

striated muscle cell differentiation

MAPK signaling pathway

ErbB signaling pathway

Chemokine signaling pathway

Dorso-ventral axis formation

Axon guidance

VEGF signaling pathway

Tight junction

Gap junction

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Long-term potentiation

Neurotrophin signaling pathway

Long-term depression

Regulation of actin cytoskeleton

Insulin signaling pathway

GnRH signaling pathway

Melanogenesis

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Endometrial cancer

Glioma

Prostate cancer

Thyroid cancer

Melanoma

Bladder cancer

Chronic myeloid leukemia

Acute myeloid leukemia

Non-small cell lung cancer

209384_at PROSC proline synthetase co-transcribed homolog (bacterial) 8 37739258 AA176833 8p11.2 Hs.304792 Hs.608177 8

intracellular

cytoplasm

 
230280_at 0.392 2.830 2.318 3.475e-02 0.555 -3.604 TRIM9 tripartite motif-containing 9 14 -50532534, -50511730 BF057241 14q22.1 Hs.654750 11

protein binding

intracellular

cytoplasm

zinc ion binding

protein homodimerization activity

metal ion binding

 
217885_at 0.249 7.351 2.334 3.373e-02 0.552 -3.579 IPO9 importin 9 1 200064910 NM_018085 1q32.1 Hs.596014 12

protein import into nucleus, docking

nucleus

nuclear pore

cytoplasm

intracellular protein transport

Ran GTPase binding

protein transporter activity

histone binding

 
244789_at C10orf122 chromosome 10 open reading frame 122 10 -127334252 AW082215 10q26.13 Hs.148259 3    
1554351_a_at 0.552 6.182 2.222 4.184e-02 0.574 -3.757 TIPRL TIP41, TOR signaling pathway regulator-like (S. cerevisiae) 1 166414794, 166414794 BC009506 1q23.2 Hs.209431 7

protein binding

 
223138_s_at DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 3 -155476150 AI937206 3p13-q23 Hs.446270 13

nucleotide binding

nucleic acid binding

helicase activity

protein binding

ATP binding

nucleus

cytoplasm

ATP-dependent helicase activity

hydrolase activity

 
212426_s_at YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 2 -9641556 BF033313 2p25.1 Hs.74405 93

cytoplasm

protein targeting

small GTPase mediated signal transduction

protein domain specific binding

negative regulation of transcription, DNA-dependent

protein N-terminus binding

Cell cycle

Neurotrophin signaling pathway

Pathogenic Escherichia coli infection - EHEC

222671_s_at 0.267 5.483 2.154 4.768e-02 0.586 -3.865 JMJD4 jumonji domain containing 4 1 -225985513 AA582199 1q42.13 Hs.325081 Hs.555974 2    
231158_x_at PTBP1 polypyrimidine tract binding protein 1 19 748391 AI380289 19p13.3 Hs.172550 65

nucleotide binding

nuclear mRNA splicing, via spliceosome

RNA binding

protein binding

nucleus

nucleoplasm

nucleolus

poly-pyrimidine tract binding

RNA splicing

heterogeneous nuclear ribonucleoprotein complex

 
202947_s_at GYPC glycophorin C (Gerbich blood group) 2 127130153 NM_002101 2q14-q21 Hs.59138 31

protein binding

plasma membrane

integral to plasma membrane

protein amino acid N-linked glycosylation

protein amino acid O-linked glycosylation

organ morphogenesis

cortical cytoskeleton

 
1558217_at SLFN13 schlafen family member 13 17 -30786227 AK074465 17q12 Hs.462833 8

nucleotide binding

ATP binding

intracellular

 
212972_x_at APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 4 -40506801 AL080130 4p14-p13 Hs.479602 12

beta-amyloid binding

nucleus

cell cycle arrest

intracellular signaling cascade

transcription factor binding

membrane

lamellipodium

negative regulation of cell growth

growth cone

synapse

regulation of transcription

negative regulation of S phase of mitotic cell cycle

 
212355_at KIAA0323 KIAA0323 14 23968980 AI075450 14q12 Hs.713590 5    
203743_s_at TDG thymine-DNA glycosylase 12 102883722 NM_003211 12q24.1 Hs.584809 47

damaged DNA binding

protein binding

nucleus

nucleoplasm

nucleoplasm

base-excision repair

mismatch repair

response to DNA damage stimulus

metabolic process

pyrimidine-specific mismatch base pair DNA N-glycosylase activity

DNA N-glycosylase activity

mismatched DNA binding

depyrimidination

Base excision repair

220955_x_at RAB23 RAB23, member RAS oncogene family 6 -57161540, -57161540 NM_016277 6p11 Hs.555016 11

nucleotide binding

GTP binding

plasma membrane

signal transduction

small GTPase mediated signal transduction

nervous system development

regulation of smoothened signaling pathway

protein transport

spinal cord dorsal/ventral patterning

embryonic digit morphogenesis

negative regulation of proteolysis

Hedgehog signaling pathway

220077_at CCDC134 coiled-coil domain containing 134 22 40526623 NM_024821 22q13.2 Hs.474991 7

extracellular region

 
220805_at HRH2 histamine receptor H2 5 175017645, 175041069 NM_022304 5q35.2 Hs.247885 Hs.716212 41

receptor activity

G-protein coupled receptor activity

histamine receptor activity

plasma membrane

integral to plasma membrane

immune response

signal transduction

G-protein signaling, coupled to cyclic nucleotide second messenger

Calcium signaling pathway

Neuroactive ligand-receptor interaction

204686_at -0.957 8.297 -3.063 7.791e-03 0.381 -2.344 IRS1 insulin receptor substrate 1 2 -227304276 NM_005544 2q36 Hs.471508 290

positive regulation of mesenchymal cell proliferation

signal transducer activity

transmembrane receptor protein tyrosine kinase docking protein activity

protein kinase C binding

insulin receptor binding

insulin-like growth factor receptor binding

protein binding

nucleus

cytoplasm

microsome

plasma membrane

insulin receptor complex

caveola

signal transduction

positive regulation of glucose metabolic process

phosphoinositide 3-kinase cascade

positive regulation of cell migration

mammary gland development

positive regulation of fatty acid beta-oxidation

SH2 domain binding

glucose homeostasis

response to peptide hormone stimulus

protein kinase B signaling cascade

phosphoinositide 3-kinase binding

phosphoinositide 3-kinase binding

positive regulation of phosphoinositide 3-kinase activity

positive regulation of glycogen biosynthetic process

positive regulation of glycogen biosynthetic process

positive regulation of glucose import

negative regulation of insulin receptor signaling pathway

positive regulation of insulin receptor signaling pathway

insulin-like growth factor receptor signaling pathway

Neurotrophin signaling pathway

Insulin signaling pathway

Adipocytokine signaling pathway

Type II diabetes mellitus

202125_s_at 0.422 7.220 2.446 2.707e-02 0.525 -3.396 TRAK2 trafficking protein, kinesin binding 2 2 -201950174 NM_015049 2q33 Hs.152774 16

cytoplasm

plasma membrane

GABA receptor binding

 
216051_x_at PRINS psoriasis associated RNA induced by stress (non-protein coding) 10 24576059 AK022045 10p12.1 Hs.655386 2    
225844_at POLE4 polymerase (DNA-directed), epsilon 4 (p12 subunit) 2 75039282 NM_019896 2p12 Hs.469060 5

DNA-directed DNA polymerase activity

protein binding

intracellular

nucleus

transferase activity

nucleotidyltransferase activity

sequence-specific DNA binding

Purine metabolism

Pyrimidine metabolism

Metabolic pathways

DNA replication

Base excision repair

Nucleotide excision repair

1562617_at -0.238 4.110 -2.324 3.437e-02 0.553 -3.595 LOC340074 hypothetical LOC340074 5 -135012272 BC040891 5q31.1 Hs.434633 1    
1557719_at 0.228 5.131 2.365 3.175e-02 0.544 -3.529 PIKFYVE phosphoinositide kinase, FYVE finger containing 2 208839235, 208839235 BC017736 2q34 Hs.173939 25

nucleotide binding

protein binding

ATP binding

endosome

receptor-mediated endocytosis

intracellular signaling cascade

zinc ion binding

membrane

kinase activity

1-phosphatidylinositol-4-phosphate 5-kinase activity

transferase activity

early endosome membrane

protein localization in nucleus

retrograde transport, endosome to Golgi

cellular protein metabolic process

membrane raft

phosphatidylinositol metabolic process

metal ion binding

Inositol phosphate metabolism

Metabolic pathways

Phosphatidylinositol signaling system

Endocytosis

Fc gamma R-mediated phagocytosis

Regulation of actin cytoskeleton

209158_s_at 0.307 7.138 2.612 1.945e-02 0.489 -3.119 CYTH2 cytohesin 2 19 53664276 BC004361 19q13.33 Hs.144011 34

ARF guanyl-nucleotide exchange factor activity

protein binding

intracellular

membrane fraction

plasma membrane

endocytosis

actin cytoskeleton organization

regulation of ARF protein signal transduction

 
212815_at ASCC3 activating signal cointegrator 1 complex subunit 3 6 -101410899, -101063328 AA156961 6q16.1-q16.3 Hs.486031 10

nucleotide binding

nucleic acid binding

helicase activity

ATP binding

intracellular

cytoplasm

ATP-dependent helicase activity

hydrolase activity

regulation of transcription

 
229433_at RBM26 RNA binding motif protein 26 13 -78792099 AU144571 13q31.1 Hs.558528 8

nucleotide binding

RNA binding

zinc ion binding

metal ion binding

 
221667_s_at 0.438 11.262 2.195 4.409e-02 0.579 -3.800 HSPB8 heat shock 22kDa protein 8 12 118100977 AF133207 12q24.23 Hs.400095 48

protein serine/threonine kinase activity

cellular_component

intracellular

biological_process

cell death

response to heat

identical protein binding

 
229287_at PCNX pecanex homolog (Drosophila) 14 70443874 BE326214 14q24.2 Hs.446559 10

membrane

integral to membrane

 
202879_s_at CYTH1 cytohesin 1 17 -74181724 AI798823 17q25 Hs.191215 28

ARF guanyl-nucleotide exchange factor activity

protein binding

intracellular

cytoplasm

plasma membrane

vesicle-mediated transport

regulation of cell adhesion

regulation of ARF protein signal transduction

 
221979_at 0.405 7.309 3.222 5.617e-03 0.354 -2.066 LOC100129250 similar to hCG1811779 9   AI150117 9p21.1 Hs.664395      
200765_x_at CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 5 138117005 NM_001903 5q31 Hs.534797 Hs.656653 70

structural molecule activity

protein binding

cytoplasm

plasma membrane

adherens junction

cell adhesion

actin cytoskeleton

vinculin binding

cell junction

apical junction assembly

cadherin binding

Adherens junction

Tight junction

Leukocyte transendothelial migration

Pathways in cancer

Endometrial cancer

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

234290_x_at MYH14 myosin, heavy chain 14 19 55398696 BC000676 19q13.33 Hs.467142 19

nucleotide binding

motor activity

actin binding

calmodulin binding

ATP binding

regulation of cell shape

myosin complex

Tight junction

Regulation of actin cytoskeleton

229105_at GPR39 G protein-coupled receptor 39 2 132890616 AV717094 2q21-q22 Hs.432395 Hs.719231 14

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

zinc ion binding

metal ion binding

 
218187_s_at 0.258 6.176 2.813 1.296e-02 0.432 -2.776 C8orf33 chromosome 8 open reading frame 33 8 146248627 NM_023080 8q24.3 Hs.169615 3    
233954_at -0.425 3.409 -3.878 1.452e-03 0.250 -0.916 HIATL1 hippocampus abundant transcript-like 1 9 96176653 AL110135 9q22.32 Hs.555996 Hs.715500 7

transporter activity

protein binding

transport

tetracycline:hydrogen antiporter activity

tetracycline transport

membrane

integral to membrane

response to antibiotic

 
205736_at -0.956 11.227 -3.283 4.949e-03 0.343 -1.958 PGAM2 phosphoglycerate mutase 2 (muscle) 7 -44068850 NM_000290 7p13-p12 Hs.632642 9

bisphosphoglycerate mutase activity

2,3-bisphospho-D-glycerate 2-phosphohydrolase activity

phosphoglycerate mutase activity

cellular_component

glycolysis

striated muscle contraction

metabolic process

hydrolase activity

isomerase activity

Glycolysis / Gluconeogenesis

Biosynthesis of phenylpropanoids

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from shikimate pathway

Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

211306_s_at FCAR Fc fragment of IgA, receptor for 19 60077360, 60077360 U56237 19q13.2-q13.4 Hs.659872 52

receptor activity

extracellular region

plasma membrane

integral to plasma membrane

immune response

IgA binding

 
222875_at 0.462 6.775 3.572 2.729e-03 0.290 -1.451 DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 17 -5286314 AI720923 17p13.2 Hs.250456 4

nucleotide binding

nucleic acid binding

helicase activity

ATP binding

nucleus

nucleolus

ATP-dependent helicase activity

hydrolase activity

 
200685_at SFRS11 splicing factor, arginine/serine-rich 11 1 70443952 AU146237 1p31 Hs.479693 13

nucleotide binding

nuclear mRNA splicing, via spliceosome

RNA binding

protein binding

nucleus

nucleolus

RNA splicing

 
229927_at LEMD1 LEM domain containing 1 1 -203617135 BE222220 1q32.1 Hs.655520 2

nuclear envelope

membrane

integral to membrane

 
208135_at HNF1B HNF1 homeobox B 17 -33120546 NM_006481 17cen-q21.3 Hs.191144 87

kidney development

transcription factor activity

nucleus

nucleolus

transcription activator activity

sequence-specific DNA binding

positive regulation of transcription, DNA-dependent

Maturity onset diabetes of the young

207498_s_at CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 22 -40852444 NM_000106 22q13.1 Hs.648256 524

endoplasmic reticulum

microsome

electron carrier activity

membrane

drug metabolic process

heme binding

metal ion binding

oxidation reduction

aromatase activity

Drug metabolism - cytochrome P450

Biosynthesis of alkaloids derived from shikimate pathway

211820_x_at -0.265 3.783 -2.987 9.092e-03 0.398 -2.475 GYPA glycophorin A (MNS blood group) 4 -145249905 U00179 4q28.2-q31.1 Hs.434973 60

membrane fraction

plasma membrane

integral to membrane

identical protein binding

Hematopoietic cell lineage

227028_s_at DGCR2 DiGeorge syndrome critical region gene 2 22 -17403794 AA534295 22q11.21 Hs.517357 14

receptor activity

protein binding

sugar binding

microsome

cell adhesion

organ morphogenesis

membrane

integral to membrane

response to drug

 
222418_s_at 1.023 7.610 3.207 5.797e-03 0.357 -2.093 TMEM43 transmembrane protein 43 3 14141440 AA115485 3p25.1 Hs.517817 18

nucleus

endoplasmic reticulum

Golgi apparatus

membrane

integral to membrane

 
224801_at NDFIP2 Nedd4 family interacting protein 2 13 78953259 AI655642 13q31.1 Hs.525093 12

signal transducer activity

protein binding

cytoplasm

mitochondrion

endosome

endoplasmic reticulum

Golgi apparatus

negative regulation of gene expression

membrane

integral to membrane

positive regulation of protein ubiquitination

negative regulation of transporter activity

positive regulation of I-kappaB kinase/NF-kappaB cascade

perinuclear region of cytoplasm

WW domain binding

negative regulation of protein transport

 
1559571_a_at ATP13A4 ATPase type 13A4 3 -194602559 AK095277 3q29 Hs.674423 4

nucleotide binding

magnesium ion binding

ATP binding

ATP biosynthetic process

cation transport

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

membrane

integral to membrane

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

ATPase activity

 
1559942_at 0.398 4.414 2.287 3.693e-02 0.562 -3.654 MDFIC MyoD family inhibitor domain containing 7 114349444 BC040713 7q31.1-q31.2 Hs.427236 7

nucleus

nucleolus

cytoplasm

activation of JUN kinase activity

regulation of Wnt receptor signaling pathway

cyclin binding

Tat protein binding

interspecies interaction between organisms

regulation of transcription

positive regulation of viral transcription

 
228079_at C3orf58 chromosome 3 open reading frame 58 3 145173329, 145174856 AI343351 3q24 Hs.288954 5

extracellular region

 
225026_at CHD6 chromodomain helicase DNA binding protein 6 20 -39464583 BF572029 20q12 Hs.371979 12

nucleotide binding

chromatin

DNA binding

chromatin binding

helicase activity

ATP binding

nucleus

chromatin assembly or disassembly

chromatin remodeling

regulation of transcription, DNA-dependent

nervous system development

ATP-dependent helicase activity

hydrolase activity

 
225700_at -0.294 3.837 -2.442 2.725e-02 0.526 -3.401 GLCCI1 glucocorticoid induced transcript 1 7 7974947 AC006042 7p21.3 Hs.131673 9    
201944_at 0.474 7.742 3.280 4.987e-03 0.343 -1.964 HEXB hexosaminidase B (beta polypeptide) 5 74016724 NM_000521 5q13 Hs.69293 66

skeletal system development

acrosomal vesicle

hydrolase activity, hydrolyzing O-glycosyl compounds

beta-N-acetylhexosaminidase activity

lysosome

carbohydrate metabolic process

glycosphingolipid metabolic process

ganglioside catabolic process

cellular calcium ion homeostasis

lysosome organization

penetration of zona pellucida

sensory perception of sound

locomotory behavior

male courtship behavior

metabolic process

phospholipid biosynthetic process

oligosaccharide catabolic process

membrane

lipid storage

sexual reproduction

glycosaminoglycan metabolic process

regulation of cellular metabolic process

myelination

protein homodimerization activity

cation binding

cellular protein metabolic process

protein heterodimerization activity

oogenesis

neuromuscular process controlling balance

Other glycan degradation

Amino sugar and nucleotide sugar metabolism

Glycosaminoglycan degradation

Glycosphingolipid biosynthesis - globo series

Glycosphingolipid biosynthesis - ganglio series

Metabolic pathways

Lysosome

1563728_at NCRNA00032 non-protein coding RNA 32 9 -27235683 AF418573 9p21 Hs.201554 1    
208029_s_at LAPTM4B lysosomal protein transmembrane 4 beta 8 98856984 NM_018407 8q22.1 Hs.492314 17

transport

endomembrane system

membrane

integral to membrane

Lysosome

1557981_at -0.272 4.118 -2.938 1.006e-02 0.415 -2.561 RPS9 ribosomal protein S9 19 59396537 AK095055 19q13.4 Hs.467284 Hs.546288 20

structural constituent of ribosome

protein binding

intracellular

nucleolus

cytoplasm

cytosol

ribosome

translational elongation

positive regulation of cell proliferation

rRNA binding

cytosolic small ribosomal subunit

translation regulator activity

Ribosome

203535_at 0.479 4.123 2.663 1.758e-02 0.473 -3.033 S100A9 S100 calcium binding protein A9 1 151596953 NM_002965 1q21 Hs.112405 102

signal transducer activity

calcium ion binding

protein binding

nucleus

nucleolus

cytoplasm

inflammatory response

cell-cell signaling

leukocyte chemotaxis

actin cytoskeleton reorganization

regulation of integrin biosynthetic process

 
1563228_x_at SLC38A10 solute carrier family 38, member 10 17 -76839265, -76833393 BC020925 17q25.3 Hs.352240 2

ion transport

sodium ion transport

amino acid transport

membrane

integral to membrane

sodium ion binding

 
201574_at 0.375 8.905 2.683 1.689e-02 0.467 -3.000 ETF1 eukaryotic translation termination factor 1 5 -137869682 NM_004730 5q31.1 Hs.483494 32

RNA binding

protein binding

cytoplasm

regulation of translational termination

protein amino acid methylation

translation release factor activity, codon specific

ribosome binding

 
204605_at CGRRF1 cell growth regulator with ring finger domain 1 14 54046336 NM_006568 14q22.2 Hs.59106 5

protein binding

response to stress

cell cycle

cell cycle arrest

zinc ion binding

negative regulation of cell proliferation

negative regulation of cell growth

metal ion binding

 
201274_at 0.242 8.803 2.553 2.190e-02 0.499 -3.218 PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 1 -109745994 NM_002790 1p13 Hs.712557 45

threonine-type endopeptidase activity

protein binding

nucleus

cytoplasm

cytosol

proteasome core complex

ubiquitin-dependent protein catabolic process

peptidase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

proteolysis involved in cellular protein catabolic process

Proteasome

228459_at FAM84A family with sequence similarity 84, member A 2 14690306 BF063776 2p24.3 Hs.260855 6    
212017_at 0.226 8.302 2.251 3.955e-02 0.568 -3.711 FAM168B family with sequence similarity 168, member B 2 -131521918 BF677404 2q21.1 Hs.534679 2    
1558119_at -0.222 4.851 -2.182 4.520e-02 0.581 -3.821 TSPAN17 tetraspanin 17 5 176006993 BG769410 5q35.3 Hs.532129 6

ubiquitin ligase complex

ubiquitin-protein ligase activity

protein binding

membrane

integral to membrane

protein ubiquitination

 
1558459_s_at LOC401320 hypothetical LOC401320 7   BC041636 7p15.1 Hs.561708 2    
234130_at LDB3 LIM domain binding 3 10 88418300, 88418405, 88418405 AL359621 10q22.3-q23.2 Hs.657271 15

protein binding

cytoplasm

cytoskeleton

zinc ion binding

Z disc

pseudopodium

metal ion binding

perinuclear region of cytoplasm

 
215673_at -0.212 2.075 -2.660 1.765e-02 0.473 -3.037 TEF thyrotrophic embryonic factor 22 40093337, 40107908 AB051442 22q13 22q13.2 Hs.181159 14

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

regulation of transcription from RNA polymerase II promoter

sequence-specific DNA binding

protein dimerization activity

rhythmic process

 
226090_x_at RABL3 RAB, member of RAS oncogene family-like 3 3 -121888217 AK025772 3q13.33 Hs.444360 1

nucleotide binding

GTP binding

intracellular

small GTPase mediated signal transduction

 
218789_s_at 0.558 7.206 3.676 2.203e-03 0.276 -1.269 C11orf71 chromosome 11 open reading frame 71 11 -113767379 NM_019021 11q14.2-q14.3 Hs.715083 3    
238772_at ZNF207 zinc finger protein 207 17 27701269 BF055042 17q11.2 Hs.500775 7

transcription factor activity

intracellular

nucleus

nucleolus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
1562303_at ZKSCAN3 zinc finger with KRAB and SCAN domains 3 6 28425669 AK091225 6p22.1 Hs.485004 11

transcription factor activity

protein binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
242215_at GRIK4 glutamate receptor, ionotropic, kainate 4 11 120036237 AI699933 11q22.3 Hs.568901 14

receptor activity

ion channel activity

extracellular-glutamate-gated ion channel activity

protein binding

membrane fraction

plasma membrane

integral to plasma membrane

ion transport

glutamate signaling pathway

synaptic transmission

kainate selective glutamate receptor activity

cell junction

kainate selective glutamate receptor complex

presynaptic membrane

synapse

postsynaptic membrane

Neuroactive ligand-receptor interaction

218159_at DDRGK1 DDRGK domain containing 1 20 -3119011 NM_023935 20p13 Hs.471975 4

protein binding

extracellular region

 
239325_at LOC729723 hypothetical LOC729723 2   AW291033 2p23.3 Hs.436366      
238856_s_at PANK2 pantothenate kinase 2 20 3817485, 3817741, 3818462 BG108346 20p13 Hs.516859 33

nucleotide binding

pantothenate kinase activity

protein binding

ATP binding

cytoplasm

mitochondrion

coenzyme A biosynthetic process

transferase activity

Pantothenate and CoA biosynthesis

Metabolic pathways

201545_s_at 0.317 6.402 2.400 2.961e-02 0.536 -3.471 PABPN1 poly(A) binding protein, nuclear 1 14 22859236 NM_004643 14q11.2-q13 Hs.707712 42

nucleotide binding

nuclear mRNA splicing, via spliceosome

RNA binding

protein binding

nucleus

nucleoplasm

nucleolus

cytoplasm

muscle contraction

poly(A)+ mRNA export from nucleus

 
228236_at C20orf54 chromosome 20 open reading frame 54 20 -688723 AA903862 20p13 Hs.283865 6

membrane

integral to membrane

 
202792_s_at SAPS2 SAPS domain family, member 2 22 49128625 NM_014678 22q13.33 Hs.449098 Hs.710221 8

protein binding

cytoplasm

 
1560001_at LOC100131581 hypothetical LOC100131581 8   AK092544 8p23.1 Hs.638992 1    
1555559_s_at USP25 ubiquitin specific peptidase 25 21 16024366 AF419247 21q11.2 Hs.473370 11

ubiquitin thiolesterase activity

ubiquitin-specific protease activity

protein modification process

proteolysis

ubiquitin-dependent protein catabolic process

peptidase activity

cysteine-type peptidase activity

 
204747_at IFIT3 interferon-induced protein with tetratricopeptide repeats 3 10 91077581, 91082218 NM_001549 10q24 Hs.714337 14

binding

cellular_component

biological_process

 
228573_at 0.895 5.054 3.763 1.839e-03 0.270 -1.116 ANTXR2 anthrax toxin receptor 2 4 -81117685, -81041796 BE673665 4q21.21 Hs.162963 22

receptor activity

protein binding

extracellular region

endoplasmic reticulum

plasma membrane

integral to membrane

metal ion binding

 
209860_s_at 0.359 9.710 2.140 4.896e-02 0.590 -3.886 ANXA7 annexin A7 10 -74805194 J04543 10q21.1-q21.2 Hs.631827 24

calcium ion binding

calcium-dependent phospholipid binding

calcium-dependent protein binding

 
237247_at USP51 ubiquitin specific peptidase 51 X -55529686 AI341140 Xp11.21 Hs.134289 9

ubiquitin thiolesterase activity

ubiquitin-dependent protein catabolic process

peptidase activity

cysteine-type peptidase activity

zinc ion binding

metal ion binding

 
209672_s_at MIOS missing oocyte, meiosis regulator, homolog (Drosophila) 7 7573140 AL136892 7p22-p21 Hs.520215 4    
211181_x_at RUNX1 runt-related transcription factor 1 21 -35115443, -35081967, -35081967 AF312386 21q22.3 Hs.149261 Hs.612648 256

transcription factor activity

protein binding

ATP binding

nucleus

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

transcription activator activity

positive regulation of granulocyte differentiation

chloride ion binding

positive regulation of angiogenesis

positive regulation of transcription from RNA polymerase II promoter

Pathways in cancer

Chronic myeloid leukemia

Acute myeloid leukemia

1552626_a_at TMEM163 transmembrane protein 163 2 -134929800 NM_030923 2q21.3 Hs.369471 Hs.595089 5

membrane

integral to membrane

 
224079_at IL17C interleukin 17C 16 87232501 AF152099 16q24 Hs.278911 5

cytokine activity

extracellular region

extracellular space

soluble fraction

inflammatory response

cell surface receptor linked signal transduction

cell-cell signaling

neutrophil differentiation

 
227413_at UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 5 158622666 BF965546 5q33.3 Hs.591733 7

phosphoprotein phosphatase activity

nucleus

hydrolase activity

 
227408_s_at SNX25 sorting nexin 25 4 186368277 AW008976 4q35.1 Hs.369091 4

signal transducer activity

protein binding

cell communication

protein transport

phosphoinositide binding

 
224303_x_at NIN ninein (GSK3B interacting protein) 14 -50263700, -50262296, -50262296, -50256230 AF223938 14q22.1 Hs.310429 23

nucleotide binding

protein binding

GTP binding

centrosome

microtubule

centrosome localization

 
209909_s_at 0.890 2.853 2.622 1.907e-02 0.489 -3.102 TGFB2 transforming growth factor, beta 2 1 216586013 M19154 1q41 Hs.133379 112

cell morphogenesis

skeletal system development

cartilage condensation

angiogenesis

beta-amyloid binding

blood vessel development

eye development

response to hypoxia

blood vessel remodeling

receptor signaling protein serine/threonine kinase activity

type II transforming growth factor beta receptor binding

type II transforming growth factor beta receptor binding

cytokine activity

extracellular region

extracellular region

extracellular region

extracellular space

induction of apoptosis

activation-induced cell death of T cells

cell cycle arrest

transforming growth factor beta receptor signaling pathway

SMAD protein nuclear translocation

cell-cell signaling

axon guidance

salivary gland morphogenesis

growth factor activity

cell death

positive regulation of cell proliferation

glial cell migration

embryonic development

positive regulation of epithelial cell migration

negative regulation of alkaline phosphatase activity

positive regulation of epithelial to mesenchymal transition

positive regulation of phosphoinositide 3-kinase cascade

menstrual cycle phase

hemopoiesis

collagen fibril organization

positive regulation of cell growth

negative regulation of cell growth

axon

neutrophil chemotaxis

neutrophil chemotaxis

extracellular matrix

hair follicle morphogenesis

platelet alpha granule lumen

activation of protein kinase activity

response to progesterone stimulus

positive regulation of stress-activated MAPK cascade

regulation of transforming growth factor-beta2 production

positive regulation of cell adhesion mediated by integrin

wound healing

dopamine biosynthetic process

odontogenesis

protein homodimerization activity

cell soma

positive regulation of neuron apoptosis

cell-cell junction organization

positive regulation of integrin biosynthetic process

positive regulation of ossification

positive regulation of cell cycle

positive regulation of heart contraction

protein heterodimerization activity

somatic stem cell division

neuron fate commitment

neuron development

generation of neurons

negative regulation of epithelial cell proliferation

negative regulation of epithelial cell proliferation

positive regulation of protein secretion

negative regulation of immune response

positive regulation of immune response

positive regulation of catagen

positive regulation of cardioblast differentiation

cardiac muscle cell proliferation

cardiac epithelial to mesenchymal transition

pathway-restricted SMAD protein phosphorylation

MAPK signaling pathway

Cytokine-cytokine receptor interaction

Cell cycle

TGF-beta signaling pathway

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Chronic myeloid leukemia

Hypertrophic cardiomyopathy (HCM)

208373_s_at -0.321 5.275 -3.197 5.917e-03 0.357 -2.110 P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 11 72653217, 72658586, 72660894 NM_004154 11q13.5 Hs.16362 23

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

signal transduction

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

transepithelial chloride transport

purinergic nucleotide receptor activity, G-protein coupled

UDP-activated nucleotide receptor activity

Neuroactive ligand-receptor interaction

214906_x_at N4BP2L1 NEDD4 binding protein 2-like 1 13 -31872859 AL049786 13q12-q13 Hs.161220 2    
237044_s_at C10orf41 chromosome 10 open reading frame 41 10 76831291, 76833519 AI480142 10q22.2 Hs.534598 Hs.599628 4    
211818_s_at -0.307 5.992 -2.504 2.413e-02 0.510 -3.300 PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) 19 -18179770, -18179770, -18179770 U88712 19p13.11 Hs.132584 13

3',5'-cyclic-AMP phosphodiesterase activity

signal transduction

hydrolase activity

Purine metabolism

1557211_a_at 0.402 3.385 2.374 3.116e-02 0.543 -3.513 C14orf86 chromosome 14 open reading frame 86 14 -93440828 BC037859 14q32.12 Hs.585649 1    
231454_at PLAC4 placenta-specific 4 21 -41469027 R31094 21q22.2 Hs.472492 3    
220634_at TBX4 T-box 4 17 56888588 NM_018488 17q21-q22 Hs.143907 7

angiogenesis

morphogenesis of an epithelium

transcription factor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

lung development

embryonic limb morphogenesis

leg morphogenesis

skeletal system morphogenesis

 
233078_at API5 apoptosis inhibitor 5 11 43290080 AK021649 11p11.2 Hs.435771 15

binding

nucleus

spliceosomal complex

cytoplasm

apoptosis

anti-apoptosis

anti-apoptosis

anti-apoptosis

fibroblast growth factor binding

 
205656_at PCDH17 protocadherin 17 13 57103789 NM_014459 13q21.1 Hs.106511 11

calcium ion binding

protein binding

plasma membrane

cell adhesion

homophilic cell adhesion

integral to membrane

 
214718_at GATAD1 GATA zinc finger domain containing 1 7 91914700 AK026142 7q21-q22 Hs.21145 6

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
212922_s_at SMYD2 SET and MYND domain containing 2 1 212521187 AI809870 1q32.3-q41 Hs.66170 11

protein binding

zinc ion binding

metal ion binding

 
212967_x_at NAP1L1 nucleosome assembly protein 1-like 1 12 -74724938 AW148801 12q21.2 Hs.524599 Hs.695185 17

protein binding

nucleus

chromatin assembly complex

DNA replication

nucleosome assembly

positive regulation of cell proliferation

melanosome

 
225288_at COL27A1 collagen, type XXVII, alpha 1 9 115958051 AI949136 9q32 Hs.494892 8

extracellular matrix structural constituent

extracellular region

collagen

cell adhesion

 
211072_x_at 0.483 10.538 2.337 3.354e-02 0.552 -3.574 TUBA1B tubulin, alpha 1b 12 -47807832 BC006481 12q13.12 Hs.524390 Hs.719075 42

nucleotide binding

microtubule cytoskeleton organization

GTPase activity

structural constituent of cytoskeleton

protein binding

GTP binding

microtubule

microtubule-based movement

protein complex

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

235695_at INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 2 98427752, 98427752 AI051236 2q11.2 Hs.469386 16

signal transduction

phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity

hydrolase activity

phosphatidyl-inositol-4,5-bisphosphate 4-phosphatase activity

Inositol phosphate metabolism

Metabolic pathways

Phosphatidylinositol signaling system

217924_at C6orf106 chromosome 6 open reading frame 106 6 -34663047 AL523965 6p21.31 Hs.643498 10    
208809_s_at 0.353 8.603 2.496 2.451e-02 0.513 -3.313 C6orf62 chromosome 6 open reading frame 62 6 -24813069 AL136632 6p22.3 Hs.519930 6

molecular_function

cellular_component

intracellular

biological_process

 
204807_at TMEM5 transmembrane protein 5 12 62459903 BF224146 12q14.2 Hs.216386 3

integral to plasma membrane

membrane

 
219939_s_at CSDE1 cold shock domain containing E1, RNA-binding 1 -115061060, -115061060, -115061059 NM_007158 1p22 Hs.69855 25

DNA binding

RNA binding

protein binding

cytoplasm

regulation of transcription, DNA-dependent

male gonad development

 
201533_at CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 3 41215945 NM_001904 3p21 Hs.476018 680

negative regulation of transcription from RNA polymerase II promoter

skeletal system development

patterning of blood vessels

gastrulation with mouth forming second

endoderm formation

cell fate specification

endodermal cell fate commitment

epithelial to mesenchymal transition

chromatin binding

double-stranded DNA binding

transcription factor activity

transcription coactivator activity

signal transducer activity

membrane fraction

nucleus

transcription factor complex

cytoplasm

centrosome

cytosol

cytoskeleton

plasma membrane

fascia adherens

apoptosis

cell-matrix adhesion

synaptic transmission

ectoderm development

glial cell fate determination

heart development

protein C-terminus binding

transcription factor binding

anterior/posterior axis specification

dorsal/ventral axis specification

proximal/distal pattern formation

positive regulation of specific transcription from RNA polymerase II promoter

positive regulation of heparan sulfate proteoglycan biosynthetic process

basolateral plasma membrane

lateral plasma membrane

morphogenesis of embryonic epithelium

cell-cell adhesion

catenin complex

kinase binding

protein phosphatase binding

Z disc

lamellipodium

hemopoiesis

lung development

androgen receptor signaling pathway

positive regulation of epithelial cell differentiation

beta-catenin destruction complex

forebrain development

regulation of centriole-centriole cohesion

pancreas development

microvillus membrane

negative regulation of chondrocyte differentiation

T cell differentiation in the thymus

cellular protein localization

Axin-APC-beta-catenin-GSK3B complex

embryonic hindlimb morphogenesis

embryonic arm morphogenesis

regulation of cell proliferation

odontogenesis of dentine-containing tooth

embryonic digit morphogenesis

apical junction complex

positive regulation of MAPKKK cascade

apical part of cell

alpha-catenin binding

cadherin binding

bone resorption

positive regulation of osteoblast differentiation

negative regulation of osteoclast differentiation

cell maturation

synaptic vesicle transport

thymus development

camera-type eye morphogenesis

androgen receptor binding

synapse organization

Wnt receptor signaling pathway through beta-catenin

beta-catenin-TCF7L2 complex

I-SMAD binding

Wnt signaling pathway

Focal adhesion

Adherens junction

Tight junction

Leukocyte transendothelial migration

Melanogenesis

Pathogenic Escherichia coli infection - EHEC

Pathways in cancer

Colorectal cancer

Endometrial cancer

Prostate cancer

Thyroid cancer

Basal cell carcinoma

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

1552491_at IDI2 isopentenyl-diphosphate delta isomerase 2 10 -1054846 NM_033261 10p15.3 Hs.591325 Hs.9270 6

magnesium ion binding

isopentenyl-diphosphate delta-isomerase activity

peroxisome

cytosol

cholesterol biosynthetic process

isoprenoid biosynthetic process

carotenoid biosynthetic process

hydrolase activity

isomerase activity

Terpenoid backbone biosynthesis

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

232265_at -0.276 4.381 -2.174 4.591e-02 0.581 -3.834 ATXN7L1 ataxin 7-like 1 7 -105187871, -105032456, -105032456 BC003517 7q22.3 Hs.489603 8    
228187_at GAS1 growth arrest-specific 1 9 -88749096 AI161237 9q21.3-q22 Hs.65029 17

positive regulation of mesenchymal cell proliferation

molecular_function

protein binding

plasma membrane

cell cycle

cell cycle arrest

axon guidance

programmed cell death

cerebellum morphogenesis

dorsal/ventral neural tube patterning

outer ear morphogenesis

middle ear morphogenesis

embryonic digit morphogenesis

regulation of apoptosis

camera-type eye development

cell fate commitment

negative regulation of S phase of mitotic cell cycle

negative regulation of smoothened signaling pathway

positive regulation of smoothened signaling pathway

anchored to plasma membrane

developmental growth

eye morphogenesis

embryonic cranial skeleton morphogenesis

embryonic skeletal system development

positive regulation of epithelial cell proliferation

negative regulation of epithelial cell proliferation

palate development

Hedgehog signaling pathway

204177_s_at KLHL20 kelch-like 20 (Drosophila) 1 171950702 NM_014458 1q24.1-q24.3 Hs.495035 10

actin binding

protein binding

cytoskeleton organization

cell surface

actin cytoskeleton

modification-dependent protein catabolic process

 
225492_at 0.527 7.533 2.653 1.792e-02 0.475 -3.050 TMEM33 transmembrane protein 33 4 41631893 BG500396 4p13 Hs.31082 5

protein binding

biological_process

membrane

integral to membrane

melanosome

 
203612_at BYSL bystin-like 6 41996942 NM_004053 6p21.1 Hs.106880 10

nucleus

nucleolus

cytoplasm

cell adhesion

female pregnancy

ribosome biogenesis

 
213172_at 0.430 3.701 2.136 4.937e-02 0.590 -3.893 TTC9 tetratricopeptide repeat domain 9 14 70178256 AW235608 14q24.2 Hs.79170 5

binding

protein folding

 
201068_s_at PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 7 102775324 NM_002803 7q22.1-q22.3 Hs.437366 56

nucleotide binding

proteasome complex

protein binding

ATP binding

nucleus

cytoplasm

cytosol

ubiquitin-dependent protein catabolic process

hydrolase activity

ATPase activity

protein catabolic process

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

interspecies interaction between organisms

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

222401_s_at 0.477 8.202 3.359 4.237e-03 0.326 -1.826 TMEM50A transmembrane protein 50A 1 25537397 AL550722 1p36.11 Hs.523054 13

cytoplasm

endoplasmic reticulum

membrane

integral to membrane

 
226452_at PDK1 pyruvate dehydrogenase kinase, isozyme 1 2 173129024 AU146532 2q31.1 Hs.470633 52

two-component sensor activity

nucleotide binding

pyruvate dehydrogenase (acetyl-transferring) kinase activity

ATP binding

mitochondrion

mitochondrial matrix

carbohydrate metabolic process

glucose metabolic process

signal transduction

small GTPase mediated signal transduction

transferase activity

peptidyl-histidine phosphorylation

T cell receptor signaling pathway

Fc epsilon RI signaling pathway

Neurotrophin signaling pathway

212764_at ZEB1 zinc finger E-box binding homeobox 1 10 31647429, 31647717, 31647752, 31648106, 31650069 AI806174 10p11.2 Hs.124503 52

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

transcription coactivator activity

transcription corepressor activity

intracellular

nucleus

immune response

zinc ion binding

cell proliferation

sequence-specific DNA binding

metal ion binding

 
223104_at JAGN1 jagunal homolog 1 (Drosophila) 3 9907270 AF212230 3p25.2 Hs.24054 6

endoplasmic reticulum

membrane

integral to membrane

 
214088_s_at -0.186 5.204 -2.270 3.816e-02 0.565 -3.681 FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 19 -5793898 AW080549 19p13.3 Hs.169238 55

membrane fraction

Golgi apparatus

carbohydrate metabolic process

protein amino acid glycosylation

membrane

integral to membrane

transferase activity, transferring glycosyl groups

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity

Glycosphingolipid biosynthesis - lacto and neolacto series

Metabolic pathways

218095_s_at TMEM165 transmembrane protein 165 4 55956846 NM_018475 4q12 Hs.479766 6

membrane

integral to membrane

 
218835_at SFTPA2 surfactant protein A2 10 -81305558, -80985613 NM_006926 10q22.3 Hs.523084 Hs.719155 17

binding

calcium ion binding

sugar binding

extracellular region

proteinaceous extracellular matrix

extracellular space

respiratory gaseous exchange

regulation of liquid surface tension

 
232902_s_at 0.404 5.887 2.822 1.273e-02 0.431 -2.761 RARS2 arginyl-tRNA synthetase 2, mitochondrial 6 -88280815 BG165118 6q16.1 Hs.485910 8

nucleotide binding

arginine-tRNA ligase activity

protein binding

ATP binding

cytoplasm

mitochondrion

mitochondrial matrix

arginyl-tRNA aminoacylation

ligase activity

Aminoacyl-tRNA biosynthesis

203912_s_at DNASE1L1 deoxyribonuclease I-like 1 X -153282772, -153282772 NM_006730 Xq28 Hs.401929 14

DNA binding

endonuclease activity

deoxyribonuclease activity

endoplasmic reticulum

DNA catabolic process

hydrolase activity

 
220372_at 0.498 4.325 2.786 1.371e-02 0.440 -2.823 DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 21 -33782107, -33782107 NM_017833 21q22.11 Hs.458308 8

heat shock protein binding

 
202708_s_at HIST2H2BE histone cluster 2, H2be 1 -148122633 NM_003528 1q21-q23 Hs.2178 50

nucleosome

DNA binding

protein binding

nucleus

chromosome

nucleosome assembly

defense response to bacterium

Systemic lupus erythematosus

228935_at SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 12 50104860, 50104860 AI570494 12q13.13 Hs.370636 13

transporter activity

inorganic anion exchanger activity

sodium ion transport

anion transport

anion transmembrane transporter activity

antiporter activity

membrane

integral to membrane

sodium ion binding

 
205406_s_at SPA17 sperm autoantigenic protein 17 11 124048949 NM_017425 11q24.2 Hs.286233 19

signal transduction

spermatogenesis

single fertilization

binding of sperm to zona pellucida

cAMP-dependent protein kinase regulator activity

membrane

 
232836_at -0.301 5.423 -2.494 2.459e-02 0.513 -3.316 C20orf61 chromosome 20 open reading frame 61 20   AL080274 20p12.2   2    
232910_at -0.342 4.339 -3.200 5.881e-03 0.357 -2.105 NCRNA00081 non-protein coding RNA 81 10 -112648478, -112648478 AK021501 10q25.2 Hs.232543 Hs.651480 4

cytoplasm

cilium

 
205746_s_at 0.315 4.163 2.460 2.632e-02 0.521 -3.372 ADAM17 ADAM metallopeptidase domain 17 2 -9546861 U86755 2p25 Hs.404914 121

response to hypoxia

positive regulation of protein amino acid phosphorylation

neutrophil mediated immunity

germinal center formation

metalloendopeptidase activity

interleukin-6 receptor binding

integrin binding

protein binding

cytoplasm

integral to plasma membrane

cell-cell junction

focal adhesion

proteolysis

epidermal growth factor receptor signaling pathway

Notch signaling pathway

peptidase activity

zinc ion binding

positive regulation of cell proliferation

response to bacterium

cell surface

positive regulation of T cell chemotaxis

actin cytoskeleton

membrane

apical plasma membrane

SH3 domain binding

PDZ domain binding

B cell differentiation

positive regulation of cell growth

positive regulation of cell migration

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cyclin-dependent protein kinase activity during G1/S

response to lipopolysaccharide

ruffle membrane

negative regulation of interleukin-8 production

positive regulation of chemokine production

regulation of mast cell apoptosis

T cell differentiation in the thymus

cell adhesion mediated by integrin

wound healing, spreading of epidermal cells

response to drug

membrane raft

positive regulation of epidermal growth factor receptor activity

metal ion binding

spleen development

cell motility

PMA-inducible membrane protein ectodomain proteolysis

response to high density lipoprotein stimulus

Notch signaling pathway

Alzheimer's disease

Epithelial cell signaling in Helicobacter pylori infection

201069_at 0.733 6.784 3.668 2.237e-03 0.276 -1.282 MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 16 54070581, 54072974 NM_004530 16q13-q21 Hs.513617 587

response to hypoxia

blood vessel maturation

intramembranous ossification

metalloendopeptidase activity

calcium ion binding

protein binding

extracellular region

proteinaceous extracellular matrix

extracellular space

plasma membrane

proteolysis

metabolic process

peptidase activity

zinc ion binding

sarcomere

collagen catabolic process

intracellular membrane-bounded organelle

face morphogenesis

bone trabecula formation

Leukocyte transendothelial migration

GnRH signaling pathway

Pathways in cancer

Bladder cancer

226168_at 0.273 6.754 2.464 2.609e-02 0.519 -3.365 ZFAND2B zinc finger, AN1-type domain 2B 2 219779781 AA524690 2q35 Hs.534540 6

protein binding

zinc ion binding

metal ion binding

 
237227_at NEK10 NIMA (never in mitosis gene a)- related kinase 10 3 -27232101 AI652681 3p24.1 Hs.506115 4

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

ATP binding

kinase activity

transferase activity

 
236073_at -0.209 5.254 -2.220 4.204e-02 0.575 -3.761 EPHA10 EPH receptor A10 1 -37998531, -37954232 AA789266 1p34.3 Hs.129435 5

nucleotide binding

receptor activity

ephrin receptor activity

ATP binding

extracellular region

plasma membrane

protein amino acid phosphorylation

transmembrane receptor protein tyrosine kinase signaling pathway

integral to membrane

transferase activity

 
206752_s_at DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 1 3763704 NM_004402 1p36.3 Hs.133089 40

DNA binding

nicotinate phosphoribosyltransferase activity

nuclease activity

caspase-activated deoxyribonuclease activity

intracellular

nucleus

nucleoplasm

cytoplasm

cytosol

DNA fragmentation involved in apoptosis

apoptosis

intracellular signaling cascade

hydrolase activity

enzyme binding

apoptotic chromosome condensation

Apoptosis

203798_s_at VSNL1 visinin-like 1 2 17585287 NM_003385 2p24.3 Hs.444212 29

calcium ion binding

 
211950_at UBR4 ubiquitin protein ligase E3 component n-recognin 4 1 -19273586 AB007931 1p36.13 Hs.148078 Hs.649405 11

ubiquitin-protein ligase activity

calmodulin binding

nucleus

cytoplasm

cytoskeleton

zinc ion binding

membrane

integral to membrane

ligase activity

modification-dependent protein catabolic process

interspecies interaction between organisms

metal ion binding

 
202816_s_at SS18 synovial sarcoma translocation, chromosome 18 18 -21850214 AW292882 18q11.2 Hs.404263 32

nucleus

 
219828_at C9orf86 chromosome 9 open reading frame 86 9 138822201 NM_024718 9q34.3 Hs.370555 11

nucleotide binding

protein binding

GTP binding

nucleus

cytoplasm

small GTPase mediated signal transduction

 
224996_at 0.546 5.867 2.616 1.932e-02 0.489 -3.113 ASPH aspartate beta-hydroxylase 8 -62739837, -62699648, -62699648, -62575669 N30209 8q12.1 Hs.591874 24

peptide-aspartate beta-dioxygenase activity

binding

iron ion binding

calcium ion binding

endoplasmic reticulum

endoplasmic reticulum membrane

muscle contraction

pattern specification process

negative regulation of cell proliferation

structural constituent of muscle

electron carrier activity

membrane

integral to membrane

oxidoreductase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

peptidyl-amino acid modification

integral to endoplasmic reticulum membrane

limb morphogenesis

peptidyl-aspartic acid hydroxylation

oxidation reduction

palate development

face morphogenesis

 
204881_s_at UGCG UDP-glucose ceramide glucosyltransferase 9 113699026 NM_003358 9q31 Hs.304249 Hs.593014 20

membrane fraction

endoplasmic reticulum

sphingolipid metabolic process

glucosylceramide biosynthetic process

ceramide glucosyltransferase activity

epidermis development

lipid biosynthetic process

membrane

integral to membrane

transferase activity, transferring glycosyl groups

Sphingolipid metabolism

Metabolic pathways

203757_s_at CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 19 46951237 BC005008 19q13.2 Hs.466814 45

plasma membrane

plasma membrane

integral to plasma membrane

signal transduction

cell-cell signaling

anchored to membrane

 
215999_at CDRT1 CMT1A duplicated region transcript 1 17 -15432701 U43383 17p12 Hs.548021 Hs.632233 7

molecular_function

cellular_component

biological_process

 
214050_at CGGBP1 CGG triplet repeat binding protein 1 3 -88183789 AI694317 3p12-p11.1 Hs.444818 14

DNA binding

double-stranded DNA binding

nucleus

regulation of transcription

 
203349_s_at 1.015 5.794 4.041 1.039e-03 0.225 -0.632 ETV5 ets variant 5 3 -187246799 NM_004454 3q28 Hs.43697 21

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

sequence-specific DNA binding

 
223126_s_at C1orf21 chromosome 1 open reading frame 21 1 182622772 AI159874 1q25 Hs.497159 Hs.719188 8    
235882_at VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 17 -382282, -361479 BF115777 17p13.3 Hs.461819 11

endosome

Golgi apparatus

protein transport

membrane

 
215910_s_at -0.255 3.823 -2.769 1.420e-02 0.446 -2.853 FNDC3A fibronectin type III domain containing 3A 13 48448048, 48582449 AL137000 13q14.2 Hs.508010 10

acrosomal vesicle

Golgi apparatus

cytosol

spermatid development

fertilization

vesicle membrane

cell-cell adhesion

cytoplasmic vesicle

vesicular fraction

Sertoli cell development

 
221568_s_at LIN7C lin-7 homolog C (C. elegans) 11 -27472546 AF090900 11p14 Hs.693840 Hs.91393 16

protein binding

plasma membrane

tight junction

exocytosis

neurotransmitter secretion

protein transport

synaptosome

cell junction

synapse

postsynaptic membrane

 
202484_s_at 0.435 7.103 3.202 5.858e-03 0.357 -2.101 MBD2 methyl-CpG binding domain protein 2 18 -49983044, -49934572 AF072242 18q21 Hs.25674 50

histone deacetylase complex

negative regulation of transcription from RNA polymerase II promoter

heterochromatin

DNA binding

chromatin binding

satellite DNA binding

mRNA binding

nucleus

nucleus

cytoplasm

methyl-CpG binding

negative regulation of transcription

transcription repressor activity

positive regulation of Wnt receptor signaling pathway

siRNA binding

regulation of cell proliferation

maternal behavior

cellular protein complex assembly

C2H2 zinc finger domain binding

 
224851_at CDK6 cyclin-dependent kinase 6 7 -92072172, -92072172 AW274756 7q21-q22 Hs.119882 95

G1 phase of mitotic cell cycle

nucleotide binding

cyclin-dependent protein kinase holoenzyme complex

ruffle

positive regulation of cell-matrix adhesion

cyclin-dependent protein kinase activity

ATP binding

nucleus

cytoplasm

protein amino acid phosphorylation

regulation of gene expression

regulation of gene expression

transferase activity

hemopoiesis

cyclin binding

gliogenesis

cell dedifferentiation

regulation of erythrocyte differentiation

negative regulation of osteoblast differentiation

negative regulation of cell cycle

positive regulation of fibroblast proliferation

negative regulation of epithelial cell proliferation

cell division

Cell cycle

p53 signaling pathway

Pathways in cancer

Pancreatic cancer

Glioma

Melanoma

Chronic myeloid leukemia

Small cell lung cancer

Non-small cell lung cancer

38691_s_at SFTPC surfactant protein C 8 22075128 J03553 8p21 Hs.1074 68

extracellular region

extracellular space

respiratory gaseous exchange

regulation of liquid surface tension

 
219812_at PVRIG poliovirus receptor related immunoglobulin domain containing 7 99654806 NM_024070 7q22.1 Hs.521075 4

membrane

integral to membrane

 
243547_at FLJ39639 hypothetical protein FLJ39639 16   BE176531 16p13.3 Hs.592092 2    
221748_s_at 0.353 10.280 2.317 3.485e-02 0.555 -3.606 TNS1 tensin 1 2 -218372756 AL046979 2q35-q36 Hs.471381 16

actin binding

protein binding

cytoplasm

cytoskeleton

focal adhesion

cell junction

 
232366_at KIAA0232 KIAA0232 4 6835359 AF143884 4p16.1 Hs.79276 7

nucleotide binding

ATP binding

 
220048_at EDAR ectodysplasin A receptor 2 -108877358 NM_022336 2q11-q13 Hs.171971 23

hair follicle development

transmembrane receptor activity

protein binding

plasma membrane

apoptosis

signal transduction

multicellular organismal development

salivary gland development

integral to membrane

cell differentiation

positive regulation of NF-kappaB import into nucleus

odontogenesis of dentine-containing tooth

pigmentation

apical part of cell

Cytokine-cytokine receptor interaction

221489_s_at SPRY4 sprouty homolog 4 (Drosophila) 5 -141670175 W48843 5q31.3 Hs.323308 14

protein binding

cytoplasm

plasma membrane

multicellular organismal development

regulation of signal transduction

cell projection

negative regulation of MAP kinase activity

Jak-STAT signaling pathway

1554129_a_at ADIG adipogenin 20 36643251 BC029594 20q11.23 Hs.368028 3

nucleus

cytoplasm

membrane

integral to membrane

positive regulation of fat cell differentiation

white fat cell differentiation

brown fat cell differentiation

 
201258_at -0.401 11.844 -2.344 3.308e-02 0.551 -3.563 RPS16 ribosomal protein S16 19 -44615686 NM_001020 19q13.1 Hs.397609 24

RNA binding

structural constituent of ribosome

protein binding

intracellular

cytosol

ribosome

rRNA processing

translational elongation

cytosolic small ribosomal subunit

cytosolic small ribosomal subunit

ribosomal small subunit biogenesis

Ribosome

212780_at SOS1 son of sevenless homolog 1 (Drosophila) 2 -39062193 AA700167 2p22-p21 Hs.709893 107

DNA binding

Rho guanyl-nucleotide exchange factor activity

Rho GTPase activator activity

protein binding

intracellular

cytosol

plasma membrane

signal transduction

Ras protein signal transduction

Ras protein signal transduction

postsynaptic density

SH3 domain binding

regulation of Rho protein signal transduction

cell soma

positive regulation of epidermal growth factor receptor signaling pathway

nerve growth factor receptor signaling pathway

regulation of small GTPase mediated signal transduction

MAPK signaling pathway

ErbB signaling pathway

Chemokine signaling pathway

Dorso-ventral axis formation

Focal adhesion

Gap junction

Jak-STAT signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Neurotrophin signaling pathway

Regulation of actin cytoskeleton

Insulin signaling pathway

GnRH signaling pathway

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Endometrial cancer

Glioma

Prostate cancer

Chronic myeloid leukemia

Acute myeloid leukemia

Non-small cell lung cancer

236924_at GLMN glomulin, FKBP associated protein 1 -92484542 AA814383 1p22.1 Hs.49105 14

vasculogenesis

hepatocyte growth factor receptor binding

protein binding

protein binding

intracellular

regulation of gene expression, epigenetic

negative regulation of T cell proliferation

positive regulation of phosphorylation

muscle cell differentiation

positive regulation of interleukin-2 biosynthetic process

positive regulation of cytokine secretion

 
224520_s_at 1.600 6.695 4.280 6.389e-04 0.211 -0.223 BEST3 bestrophin 3 12 -68333655, -68333655 BC006440 12q14.2-q15 Hs.280782 7

molecular_function

ion channel activity

chloride channel activity

calcium ion binding

plasma membrane

ion transport

biological_process

integral to membrane

chloride ion binding

chloride channel complex

 
213145_at FBXL14 F-box and leucine-rich repeat protein 14 12 -1545420 BF001666 12p13.33 Hs.367956 3

modification-dependent protein catabolic process

 
235086_at -0.263 3.228 -2.291 3.664e-02 0.560 -3.648 THBS1 thrombospondin 1 15 37660571 AW956580 15q15 Hs.164226 211

activation of MAPK activity

response to hypoxia

negative regulation of endothelial cell proliferation

negative regulation of endothelial cell proliferation

fibronectin binding

sprouting angiogenesis

chronic inflammatory response

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

negative regulation of dendritic cell antigen processing and presentation

integrin binding

structural molecule activity

calcium ion binding

extracellular region

extracellular region

fibrinogen complex

anti-apoptosis

immune response

cell cycle arrest

cell adhesion

heparin binding

response to glucose stimulus

external side of plasma membrane

positive regulation of oxygen and reactive oxygen species metabolic process

negative regulation of plasma membrane long-chain fatty acid transport

negative regulation of nitric oxide mediated signal transduction

negative regulation of cGMP-mediated signaling

negative regulation of plasminogen activation

positive regulation of macrophage chemotaxis

positive regulation of fibroblast migration

negative regulation of angiogenesis

peptide cross-linking

low-density lipoprotein binding

positive regulation of blood coagulation

positive regulation of transforming growth factor beta receptor signaling pathway

extracellular matrix

platelet alpha granule lumen

response to magnesium ion

response to progesterone stimulus

negative regulation of interleukin-12 production

positive regulation of transforming growth factor-beta1 production

cellular response to heat

negative regulation of fibroblast growth factor receptor signaling pathway

positive regulation of phosphorylation

identical protein binding

positive regulation of macrophage activation

laminin binding

proteoglycan binding

eukaryotic cell surface binding

positive regulation of blood vessel endothelial cell migration

negative regulation of blood vessel endothelial cell migration

engulfment of apoptotic cell

positive regulation of translation

positive regulation of angiogenesis

fibroblast growth factor 2 binding

transforming growth factor beta binding

transforming growth factor beta binding

positive regulation of chemotaxis

response to calcium ion

negative regulation of focal adhesion formation

negative regulation of fibrinolysis

fibrinogen binding

collagen V binding

p53 signaling pathway

TGF-beta signaling pathway

Focal adhesion

ECM-receptor interaction

Bladder cancer

200878_at EPAS1 endothelial PAS domain protein 1 2 46378066 AF052094 2p21-p16 Hs.468410 101

angiogenesis

response to hypoxia

embryonic placenta development

blood vessel remodeling

regulation of heart rate

RNA polymerase II transcription factor activity, enhancer binding

transcription coactivator activity

signal transducer activity

nucleus

transcription factor complex

transcription factor complex

cytoplasm

regulation of transcription, DNA-dependent

response to oxidative stress

mitochondrion organization

signal transduction

multicellular organismal development

visual perception

transcription factor binding

hemopoiesis

cell differentiation

erythrocyte differentiation

lung development

histone acetyltransferase binding

norepinephrine metabolic process

surfactant homeostasis

sequence-specific DNA binding

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

positive regulation of transcription from RNA polymerase II promoter

protein heterodimerization activity

cell maturation

Pathways in cancer

Renal cell carcinoma

31846_at -0.314 8.470 -2.980 9.223e-03 0.400 -2.487 RHOD ras homolog gene family, member D 11 66580864 AW003733 11q14.3 Hs.15114 22

nucleotide binding

GTPase activity

GTP binding

intracellular

plasma membrane

small GTPase mediated signal transduction

Rho protein signal transduction

Axon guidance

204903_x_at 0.328 7.200 3.269 5.097e-03 0.346 -1.983 ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) 2 242225699, 54821 AL080168 2q37.3 Hs.283610 19

protein binding

cytoplasm

microtubule associated complex

proteolysis

autophagy

peptidase activity

cysteine-type peptidase activity

protein transport

modification-dependent protein catabolic process

Regulation of autophagy

228311_at BCL6B B-cell CLL/lymphoma 6, member B (zinc finger protein) 17 6867092 AI827455 17p13.1 Hs.22575 8

negative regulation of transcription from RNA polymerase II promoter

DNA binding

protein binding

intracellular

nucleus

zinc ion binding

transcription repressor activity

metal ion binding

 
202695_s_at 0.667 3.819 3.356 4.257e-03 0.327 -1.830 STK17A serine/threonine kinase 17a 7 43589216 NM_004760 7p12-p14 Hs.709489 6

nucleotide binding

protein serine/threonine kinase activity

ATP binding

nucleus

protein amino acid phosphorylation

apoptosis

induction of apoptosis

protein kinase cascade

transferase activity

 
222478_at VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) 13 -51884737 AL576924 13q14.3 Hs.109520 11

nucleus

cytoplasm

lysosome

late endosome

lipid binding

protein transport

ubiquitin binding

regulation of transcription

Endocytosis

234381_at IGLV4-3 immunoglobulin lambda variable 4-3 22   D87024 22q11.2 Hs.449585 5    
201551_s_at LAMP1 lysosomal-associated membrane protein 1 13 112999469 J03263 13q34 Hs.494419 38

membrane fraction

lysosome

multivesicular body

integral to plasma membrane

external side of plasma membrane

sarcolemma

melanosome

Lysosome

235521_at -0.516 6.453 -3.323 4.560e-03 0.332 -1.888 HOXA3 homeobox A3 7 -27112333, -27112333, -27112333 AW137982 7p15-p14 Hs.659337 18

blood vessel remodeling

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

positive regulation of cell proliferation

anterior/posterior pattern formation

specification of organ position

glossopharyngeal nerve morphogenesis

thyroid gland development

sequence-specific DNA binding

thymus development

organ formation

embryonic skeletal system morphogenesis

cartilage development

parathyroid gland development

 
215951_at TBC1D2B TBC1 domain family, member 2B 15 -76074381 AL137303 15q24.3-q25.1 Hs.719242 2

GTPase activator activity

Rab GTPase activator activity

intracellular

regulation of Rab GTPase activity

 
212918_at RECQL RecQ protein-like (DNA helicase Q1-like) 12 -21513111 AI962943 12p12 Hs.235069 29

nucleotide binding

DNA strand renaturation

DNA strand annealing activity

DNA binding

ATP-dependent DNA helicase activity

protein binding

ATP binding

nucleus

DNA repair

DNA recombination

hydrolase activity

 
1559500_at -0.888 5.971 -4.067 9.853e-04 0.223 -0.588 VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 3 186012624 BC036005 3q27.2 Hs.269263 6

protein binding

zinc ion binding

metal ion binding

 
243186_at FAM117B family with sequence similarity 117, member B 2 203208145 AI523857 2q33.2 Hs.471130 5    
214545_s_at PROSC proline synthetase co-transcribed homolog (bacterial) 8 37739258 NM_007198 8p11.2 Hs.304792 Hs.608177 8

intracellular

cytoplasm

 
226704_at UBE2J2 ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) 1 -1179154 R76659 1p36.33 Hs.191987 6

nucleotide binding

ubiquitin-protein ligase activity

ATP binding

endoplasmic reticulum

membrane

integral to membrane

ligase activity

modification-dependent protein catabolic process

post-translational protein modification

regulation of protein metabolic process

Ubiquitin mediated proteolysis

Parkinson's disease

242442_x_at RG9MTD2 RNA (guanine-9-) methyltransferase domain containing 2 4 -100686894, -100686894 AL515269 4q23 Hs.380412 1

methyltransferase activity

transferase activity

 
210448_s_at P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5 17 -3540328, -3523270 U49396 17p13.3 Hs.408615 15

purinergic nucleotide receptor activity

transmembrane receptor activity

ATP-gated cation channel activity

ion channel activity

ATP binding

integral to plasma membrane

ion transport

signal transduction

nervous system development

positive regulation of calcium ion transport into cytosol

membrane

protein homodimerization activity

protein heterodimerization activity

positive regulation of calcium-mediated signaling

Calcium signaling pathway

Neuroactive ligand-receptor interaction

214696_at C17orf91 chromosome 17 open reading frame 91 17 -1561552, -1561552 AF070569 17p13.3 Hs.597755 3    
223716_s_at ZRANB2 zinc finger, RAN-binding domain containing 2 1 -71301561 AF065391 1p31 Hs.194718 18

transcription factor activity

RNA binding

protein binding

intracellular

nucleus

mRNA processing

zinc ion binding

RNA splicing

metal ion binding

 
214517_at KRTAP5-9 keratin associated protein 5-9 11 70937113 NM_005553 11q13.5 Hs.709220 7

epidermis development

keratin filament

 
207693_at CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2 -152397533, -152397533, -152397533 NM_000726 2q22-q23 Hs.120725 25

voltage-gated ion channel activity

voltage-gated calcium channel activity

calcium ion binding

protein binding

cytosol

voltage-gated calcium channel complex

ion transport

calcium ion transport

internal side of plasma membrane

regulation of calcium ion transport via voltage-gated calcium channel activity

MAPK signaling pathway

Cardiac muscle contraction

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

239924_at LOC91316 glucuronidase, beta/ immunoglobulin lambda-like polypeptide 1 pseudogene 22 -22310675 AA629699 22q11.23 Hs.148656 4    
229665_at 0.429 6.178 2.807 1.313e-02 0.433 -2.787 CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 11 -33119552, -33062705 AI653037 11p13 Hs.44402 15

nuclear mRNA splicing, via spliceosome

RNA binding

protein binding

intracellular

nucleus

mRNA polyadenylation

mRNA cleavage

 
218497_s_at RNASEH1 ribonuclease H1 2 -3570565 NM_002936 2p25 Hs.568006 20

magnesium ion binding

RNA binding

endonuclease activity

ribonuclease H activity

ribonuclease activity

cytoplasm

mitochondrion

RNA catabolic process

hydrolase activity

DNA replication

201645_at 1.857 4.142 2.593 2.021e-02 0.493 -3.151 TNC tenascin C 9 -116822625 NM_002160 9q33 Hs.143250 103

receptor binding

extracellular region

proteinaceous extracellular matrix

cell adhesion

signal transduction

response to wounding

Focal adhesion

ECM-receptor interaction

231863_at 0.410 4.417 3.469 3.375e-03 0.308 -1.632 ING3 inhibitor of growth family, member 3 7 120378052, 120378052 AF161419 7q31 Hs.489811 16

histone acetyltransferase activity

protein binding

nucleus

zinc ion binding

chromatin modification

Piccolo NuA4 histone acetyltransferase complex

NuA4 histone acetyltransferase complex

regulation of growth

positive regulation of apoptosis

histone H4 acetylation

histone H2A acetylation

regulation of transcription

metal ion binding

 
216933_x_at APC adenomatous polyposis coli 5 112071116, 112101454 S67788 5q21-q22 Hs.158932 386

cytokinesis after mitosis

kinetochore

kidney development

hair follicle development

nucleus

cytoplasm

centrosome

cytosol

cytoplasmic microtubule

protein complex assembly

response to DNA damage stimulus

negative regulation of microtubule depolymerization

cell cycle arrest

mitotic metaphase/anaphase transition

mitotic cell cycle spindle assembly checkpoint

axonogenesis

beta-catenin binding

microtubule binding

axis specification

anterior/posterior pattern formation

dorsal/ventral pattern formation

proximal/distal pattern formation

lateral plasma membrane

protein kinase regulator activity

protein kinase binding

negative regulation of Wnt receptor signaling pathway

positive regulation of cell migration

growth cone

positive regulation of epithelial cell differentiation

beta-catenin destruction complex

positive regulation of microtubule polymerization

cell projection membrane

positive regulation of pseudopodium assembly

T cell differentiation in the thymus

axon part

Axin-APC-beta-catenin-GSK3B complex

somatic stem cell maintenance

negative regulation of odontogenesis

cell projection

positive regulation of apoptosis

negative regulation of apoptosis

negative regulation of MAPKKK cascade

skin development

regulation of osteoblast differentiation

regulation of osteoclast differentiation

positive regulation of protein catabolic process

negative regulation of cyclin-dependent protein kinase activity

positive regulation of cell adhesion

muscle maintenance

thymus development

negative regulation of epithelial cell proliferation

regulation of nitrogen compound metabolic process

chromosome organization

regulation of cell cycle

positive regulation of cell division

regulation of attachment of spindle microtubules to kinetochore

retina development in camera-type eye

Wnt receptor signaling pathway through beta-catenin

Wnt receptor signaling pathway through beta-catenin

Wnt signaling pathway

Regulation of actin cytoskeleton

Pathways in cancer

Colorectal cancer

Endometrial cancer

Basal cell carcinoma

211362_s_at -0.336 3.393 -2.690 1.664e-02 0.465 -2.987 SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13 18 59405513 AF169949 18q21.3-q22 Hs.241407 12

serine-type endopeptidase inhibitor activity

cellular_component

cytoplasm

response to UV

regulation of proteolysis

peptidase inhibitor activity

 
207642_at HCRT hypocretin (orexin) neuropeptide precursor 17 -37589603 NM_001524 17q21 Hs.158348 37

rough endoplasmic reticulum

neuropeptide signaling pathway

synaptic transmission

feeding behavior

synaptic vesicle

cell junction

cytoplasmic vesicle

synapse

perinuclear region of cytoplasm

 
223441_at SLC17A5 solute carrier family 17 (anion/sugar transporter), member 5 6 -74359822 AK026921 6q14-q15 Hs.597422 28

sugar:hydrogen symporter activity

membrane fraction

lysosomal membrane

integral to plasma membrane

transport

anion transport

symporter activity

membrane

Lysosome

226810_at OGFRL1 opioid growth factor receptor-like 1 6 72055197 BE500942 6q13 Hs.648434 Hs.656091 2

receptor activity

membrane

 
208096_s_at COL21A1 collagen, type XXI, alpha 1 6 -56029346 NM_030820 6p12.3-p11.2 Hs.47629 7

structural molecule activity

extracellular region

proteinaceous extracellular matrix

cytoplasm

cell adhesion

 
203075_at SMAD2 SMAD family member 2 18 -43613464, -43613463, -43613463 AW151617 18q21.1 Hs.12253 Hs.705764 206

mesoderm formation

double-stranded DNA binding

transcription factor activity

intracellular

nucleus

nucleoplasm

cytoplasm

cytosol

SMAD protein complex assembly

intracellular signaling cascade

zygotic determination of dorsal/ventral axis

gastrulation

transcription factor binding

anterior/posterior pattern formation

positive regulation of epithelial to mesenchymal transition

promoter binding

transcription activator activity

regulation of transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

primary microRNA processing

ubiquitin protein ligase binding

activin responsive factor complex

type I transforming growth factor beta receptor binding

positive regulation of gene-specific transcription

cell fate commitment

negative regulation of transcription, DNA-dependent

positive regulation of transcription from RNA polymerase II promoter

paraxial mesoderm morphogenesis

regulation of binding

palate development

co-SMAD binding

R-SMAD binding

response to cholesterol

Cell cycle

Wnt signaling pathway

TGF-beta signaling pathway

Adherens junction

Pathways in cancer

Colorectal cancer

Pancreatic cancer

200896_x_at HDGF hepatoma-derived growth factor (high-mobility group protein 1-like) 1 -154978522, -154978522, -154978522 NM_004494 1q21-q23 Hs.506748 22

nucleotide binding

DNA binding

extracellular space

nucleus

cytoplasm

signal transduction

growth factor activity

heparin binding

cell proliferation

regulation of transcription

 
1554890_a_at TIA1 TIA1 cytotoxic granule-associated RNA binding protein 2 -70290079 BC015944 2p13 Hs.413123 34

nucleotide binding

RNA binding

protein binding

apoptosis

induction of apoptosis

poly(A) RNA binding

 
228132_at ABLIM2 actin binding LIM protein family, member 2 4 -8059647, -8017936 AI240129 4p16.1 Hs.233404 9

actin binding

cytoplasm

cytoskeleton organization

zinc ion binding

actin cytoskeleton

myofibril

positive regulation of transcription from RNA polymerase II promoter

metal ion binding

Axon guidance

219681_s_at RAB11FIP1 RAB11 family interacting protein 1 (class I) 8 -37837342, -37837342, -37835627 NM_025151 8p11.22 Hs.696035 19

protein binding

protein transport

membrane

phagocytic vesicle membrane

cytoplasmic vesicle

recycling endosome

Endocytosis

202619_s_at PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 3 -147269917 AI754404 3q23-q24 Hs.477866 20

response to hypoxia

iron ion binding

protein binding

endoplasmic reticulum

protein modification process

procollagen-lysine 5-dioxygenase activity

membrane

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

L-ascorbic acid binding

metal ion binding

oxidation reduction

Lysine degradation

1563466_at MYLK myosin light chain kinase 3 -124813832, -124813832 AL832211 3q21 Hs.477375 56

nucleotide binding

magnesium ion binding

actin binding

myosin light chain kinase activity

calcium ion binding

calmodulin binding

ATP binding

protein amino acid phosphorylation

transferase activity

Calcium signaling pathway

Vascular smooth muscle contraction

Focal adhesion

Regulation of actin cytoskeleton

212392_s_at 0.991 6.396 2.923 1.038e-02 0.418 -2.588 PDE4DIP phosphodiesterase 4D interacting protein 1 -143663117, -143663117, -143601947, -143601947, -143562783 AI950145 1q12 Hs.584841 Hs.613082 Hs.657186 Hs.657490 Hs.719077 10

nucleus

cytoplasm

Golgi apparatus

centrosome

 
1557910_at 0.634 8.999 3.054 7.928e-03 0.384 -2.359 HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 6 44322826 BG612458 6p12 Hs.509736 Hs.689683 Hs.701787 50

nucleotide binding

ATP binding

cytoplasm

protein folding

response to unfolded protein

nitric-oxide synthase regulator activity

TPR domain binding

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

melanosome

positive regulation of nitric oxide biosynthetic process

unfolded protein binding

regulation of interferon-gamma-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway

Antigen processing and presentation

Pathways in cancer

Prostate cancer

200075_s_at 0.416 7.980 2.566 2.133e-02 0.497 -3.196 GUK1 guanylate kinase 1 1 226394551, 226399026 BC006249 1q32-q41 Hs.376933 11

nucleotide binding

guanylate kinase activity

ATP binding

cytosol

purine nucleotide metabolic process

kinase activity

transferase activity

nucleoside kinase activity

Purine metabolism

Metabolic pathways

1564627_at DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 3 133619242 AK098729 3q22.1 Hs.12707 10

binding

heat shock protein binding

 
231953_at BPTF bromodomain PHD finger transcription factor 17 63252241 AK027184 17q24.3 Hs.444200 22

negative regulation of transcription from RNA polymerase II promoter

nucleus

cytoplasm

chromatin remodeling

brain development

DNA-dependent ATPase activity

transcription factor binding

zinc ion binding

transcription regulator activity

positive regulation of gene-specific transcription

sequence-specific DNA binding

sequence-specific DNA binding

regulation of transcription

metal ion binding

 
212864_at 0.359 5.190 2.614 1.938e-02 0.489 -3.115 CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 20 5055481 Y16521 20p13 Hs.719252 9

phosphatidate cytidylyltransferase activity

mitochondrion

mitochondrial inner membrane

phospholipid biosynthetic process

membrane

integral to membrane

nucleotidyltransferase activity

Glycerophospholipid metabolism

Metabolic pathways

Phosphatidylinositol signaling system

234580_at -0.259 5.999 -2.143 4.869e-02 0.590 -3.882 TMEM106A transmembrane protein 106A 17 38719419, 481039 U25750 17q21.31 Hs.567647 3

molecular_function

cellular_component

biological_process

membrane

integral to membrane

 
206647_at -0.229 4.149 -2.367 3.161e-02 0.544 -3.525 HBZ hemoglobin, zeta 16 142853 NM_005332 16p13.3 Hs.585357 24

oxygen transporter activity

hemoglobin complex

transport

oxygen transport

oxygen binding

heme binding

metal ion binding

 
232720_at LINGO2 leucine rich repeat and Ig domain containing 2 9 -27938527 AL353746 9p21.2-p21.1 Hs.715650 4

protein binding

membrane

integral to membrane

 
238648_at FLJ42291 hypothetical LOC346547 7   BE671597 7q36.2        
223645_s_at CYorf15B chromosome Y open reading frame 15B Y 20217829 BF062193 Yq11.222 Hs.592254 4    
201171_at 0.295 3.558 2.672 1.726e-02 0.471 -3.018 ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 5 172343368 NM_003945 5q35.1 Hs.484188 18

transporter activity

membrane fraction

ion transport

vacuolar acidification

ATP synthesis coupled proton transport

ATP hydrolysis coupled proton transport

proton transport

membrane

integral to membrane

cell growth

hydrolase activity

proton-transporting V-type ATPase, V0 domain

ATPase activity, coupled to transmembrane movement of ions

proton-transporting ATPase activity, rotational mechanism

Oxidative phosphorylation

Metabolic pathways

Vibrio cholerae infection

Epithelial cell signaling in Helicobacter pylori infection

222847_s_at 0.335 5.277 2.385 3.051e-02 0.541 -3.496 EGLN3 egl nine homolog 3 (C. elegans) 14 -33463171 AI378406 14q13.1 Hs.135507 26

iron ion binding

protein binding

nucleus

cytoplasm

apoptosis

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

L-ascorbic acid binding

metal ion binding

oxidation reduction

Pathways in cancer

Renal cell carcinoma

225500_x_at SCAF1 SR-related CTD-associated factor 1 19 54837193 AF254411 19q13.3-q13.4 Hs.103521 6

RNA binding

nucleus

mRNA processing

RNA splicing

 
218164_at 0.527 7.072 3.338 4.419e-03 0.330 -1.862 SPATA20 spermatogenesis associated 20 17 45979560 NM_022827 17q21.33 Hs.103147 7

catalytic activity

protein binding

multicellular organismal development

spermatogenesis

cell differentiation

 
223994_s_at SLC12A9 solute carrier family 12 (potassium/chloride transporters), member 9 7 100288293 BC000154 7q22 Hs.521087 6

plasma membrane

transport

integral to membrane

 
203762_s_at 0.341 4.976 2.182 4.515e-02 0.581 -3.820 DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2 43854685, 43854685, 43854685 NM_016008 2p25.1-p24.1 Hs.371597 7

motor activity

cytoplasm

microtubule

cilium

multicellular organismal development

determination of left/right symmetry

cell projection organization

dynein complex

cilium axoneme

cilium assembly

 
212888_at DICER1 dicer 1, ribonuclease type III 14 -94622317, -94622317 BG109746 14q32.13 Hs.87889 63

nucleotide binding

magnesium ion binding

angiogenesis

double-stranded RNA binding

helicase activity

endonuclease activity

ribonuclease III activity

protein binding

ATP binding

intracellular

cytoplasm

RNA processing

ATP-dependent helicase activity

RNA-induced silencing complex

hydrolase activity

stem cell maintenance

manganese ion binding

lung development

RNA interference, production of siRNA

RNA interference, targeting of mRNA for destruction

gene silencing by RNA

pre-microRNA processing

embryonic hindlimb morphogenesis

branching morphogenesis of a tube

 
221479_s_at 0.455 7.930 2.512 2.376e-02 0.509 -3.287 BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 8 26296439 AF060922 8p21 Hs.131226 19

lamin binding

lamin binding

nucleus

nuclear envelope

mitochondrion

mitochondrial envelope

endoplasmic reticulum

induction of apoptosis

negative regulation of survival gene product expression

membrane

integral to membrane

protein homodimerization activity

negative regulation of apoptosis

interspecies interaction between organisms

protein heterodimerization activity

defense response to virus

 
1559927_a_at LOC728353 hypothetical protein LOC728353 14   BC031683 14q11.2 Hs.621210      
209486_at UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 4 71773059 BC004546 4q13.3 Hs.322901 15

molecular_function

protein binding

nucleus

nucleolus

multicellular organismal development

brain development

gene silencing

chromatin modification

 
215688_at -0.362 4.718 -3.265 5.140e-03 0.347 -1.990 RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 15 -77039345, -77039345 AL359931 15q24.2 Hs.459035 24

Rho guanyl-nucleotide exchange factor activity

protein binding

intracellular

cytosol

plasma membrane

long-term memory

synaptosome

growth cone

neuron projection development

positive regulation of Ras GTPase activity

activation of Rac GTPase activity

regulation of Rac protein signal transduction

regulation of Rho protein signal transduction

MAPK signaling pathway

Focal adhesion

212464_s_at 1.084 8.243 3.607 2.537e-03 0.287 -1.389 FN1 fibronectin 1 2 -215987628, -215933423 X02761 2q34 Hs.203717 291

extracellular matrix structural constituent

collagen binding

extracellular region

extracellular region

fibrinogen complex

proteinaceous extracellular matrix

ER-Golgi intermediate compartment

acute-phase response

cell adhesion

heparin binding

regulation of cell shape

response to wounding

cell migration

peptide cross-linking

platelet alpha granule lumen

substrate adhesion-dependent cell spreading

Focal adhesion

ECM-receptor interaction

Regulation of actin cytoskeleton

Pathways in cancer

Small cell lung cancer

243358_at IGF1R insulin-like growth factor 1 receptor 15 97010283 BF347362 15q26.3 Hs.643120 Hs.653608 Hs.714012 315

nucleotide binding

receptor activity

insulin-like growth factor receptor activity

insulin receptor binding

ATP binding

microsome

integral to plasma membrane

anti-apoptosis

immune response

signal transduction

brain development

positive regulation of cell proliferation

insulin receptor signaling pathway

organ morphogenesis

phosphoinositide 3-kinase cascade

membrane

transferase activity

male sex determination

positive regulation of cell migration

mammary gland development

insulin-like growth factor I binding

identical protein binding

phosphoinositide 3-kinase binding

insulin binding

insulin receptor substrate binding

positive regulation of DNA replication

protein amino acid autophosphorylation

insulin-like growth factor receptor signaling pathway

phosphoinositide-mediated signaling

protein tetramerization

Endocytosis

Focal adhesion

Adherens junction

Long-term depression

Pathways in cancer

Colorectal cancer

Glioma

Prostate cancer

Melanoma

1554287_at TRIM4 tripartite motif-containing 4 7 -99325971 BC011763 7q22-q31.1 Hs.50749 8

protein binding

intracellular

cytoplasm

zinc ion binding

metal ion binding

protein trimerization

 
1552395_at -0.327 6.430 -2.823 1.272e-02 0.431 -2.760 TSSK3 testis-specific serine kinase 3 1 32600448 NM_052841 1p35-p34 Hs.512763 5

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

ATP binding

protein amino acid phosphorylation

multicellular organismal development

spermatogenesis

transferase activity

cell differentiation

 
1562841_at LOC339666 hypothetical protein LOC339666 22   BC041349 22q12.3 Hs.654761 1    
214710_s_at CCNB1 cyclin B1 5 68498668 BE407516 5q12 Hs.23960 155

G2/M transition of mitotic cell cycle

protein binding

cellular_component

nucleus

nucleoplasm

cytoplasm

centrosome

cytosol

cell cycle

mitosis

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

cell division

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Cell cycle

p53 signaling pathway

1564423_a_at -0.307 3.487 -2.927 1.029e-02 0.418 -2.580 SEC16B SEC16 homolog B (S. cerevisiae) 1 -176164864 AK098627 1q25.2 Hs.709633 10

endoplasmic reticulum

Golgi apparatus

protein transport

membrane

vesicle-mediated transport

 
238338_at DCAF8 DDB1 and CUL4 associated factor 8 1 -158475636, -158475636, -158452128, -158452128 AL134577 1q22-q23 Hs.632447 10

protein binding

 
229793_at 0.667 5.317 3.791 1.736e-03 0.267 -1.067 ASAH2B N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B 10 52169713 AI656964 10q11.23 Hs.710005 2    
1558177_at C14orf83 chromosome 14 open reading frame 83 14 -67006735 AK090706 14q24.1 Hs.509707 3

membrane

integral to membrane

 
208623_s_at 1.196 6.073 3.387 3.994e-03 0.323 -1.775 EZR ezrin 6 -159106760, -159106760 J05021 6q25.2-q26 Hs.487027 158

ruffle

cytoplasm

cytosol

actin filament

plasma membrane

microvillus

cell cortex

cytoskeletal anchoring at plasma membrane

leukocyte adhesion

cytoskeletal protein binding

regulation of cell shape

extrinsic to membrane

membrane to membrane docking

filopodium

cortical cytoskeleton

apical part of cell

cell adhesion molecule binding

actin filament binding

actin filament bundle formation

Leukocyte transendothelial migration

Regulation of actin cytoskeleton

Pathogenic Escherichia coli infection - EHEC

209218_at SQLE squalene epoxidase 8 126079900 AF098865 8q24.1 Hs.71465 16

squalene monooxygenase activity

squalene monooxygenase activity

endoplasmic reticulum

endoplasmic reticulum membrane

microsome

membrane

integral to membrane

sterol biosynthetic process

oxidoreductase activity

FAD binding

oxidation reduction

Steroid biosynthesis

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

211537_x_at 0.421 5.912 2.632 1.870e-02 0.487 -3.086 MAP3K7 mitogen-activated protein kinase kinase kinase 7 6 -91282073, -91282073 AF218074 6q16.1-q16.3 Hs.719192 114

nucleotide binding

magnesium ion binding

positive regulation of T cell cytokine production

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

protein tyrosine kinase activity

protein binding

ATP binding

cytosol

protein amino acid phosphorylation

signal transduction

transforming growth factor beta receptor signaling pathway

activation of NF-kappaB-inducing kinase activity

transferase activity

positive regulation of interleukin-2 production

T cell receptor signaling pathway

positive regulation of T cell activation

MAPK signaling pathway

Wnt signaling pathway

Adherens junction

Toll-like receptor signaling pathway

RIG-I-like receptor signaling pathway

T cell receptor signaling pathway

205527_s_at GEMIN4 gem (nuclear organelle) associated protein 4 17 -594410 NM_015487 17p13 Hs.499620 24

spliceosomal snRNP biogenesis

protein binding

nucleus

nucleoplasm

spliceosomal complex

nucleolus

cytoplasm

cytosol

rRNA processing

mRNA processing

RNA splicing

Cajal body

small nuclear ribonucleoprotein complex

 
210664_s_at 0.730 5.434 3.684 2.167e-03 0.276 -1.255 TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2 -188051550, -188037202 AF021834 2q32 Hs.516578 118

serine-type endopeptidase inhibitor activity

extracellular region

extracellular region

extracellular space

plasma membrane

blood coagulation, extrinsic pathway

Complement and coagulation cascades

242408_at 0.328 3.130 2.597 2.007e-02 0.491 -3.145 STYX serine/threonine/tyrosine interacting protein 14 52266632 AW968935   Hs.364980 8

protein amino acid dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

hydrolase activity

 
205357_s_at AGTR1 angiotensin II receptor, type 1 3 149898347, 149930656 NM_000685 3q21-q25 Hs.477887 Hs.719071 524

regulation of cell growth

angiotensin type I receptor activity

angiotensin type I receptor activity

kidney development

renin-angiotensin regulation of aldosterone production

regulation of blood vessel size by renin-angiotensin

regulation of natriuresis

receptor activity

G-protein coupled receptor activity

angiotensin type II receptor activity

plasma membrane

integral to plasma membrane

oxygen and reactive oxygen species metabolic process

signal transduction

acetyltransferase activator activity

positive regulation of foam cell differentiation

positive regulation of cholesterol esterification

regulation of vasoconstriction

regulation of vasoconstriction

regulation of vasoconstriction

calcium-mediated signaling

bradykinin receptor binding

positive regulation of cellular protein metabolic process

positive regulation of phospholipase A2 activity

positive regulation of NAD(P)H oxidase activity

low-density lipoprotein particle remodeling

regulation of cell proliferation

regulation of vasodilation

protein heterodimerization activity

positive regulation of inflammatory response

elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)

Calcium signaling pathway

Neuroactive ligand-receptor interaction

Vascular smooth muscle contraction

Renin-angiotensin system

1556988_s_at CHD1L chromodomain helicase DNA binding protein 1-like 1 145180914 BE220618 1q12 Hs.191164 12

nucleotide binding

DNA binding

helicase activity

ATP binding

nucleus

ATP-dependent helicase activity

hydrolase activity

 
224938_at NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 17 -24606979 AW007746 17q11.2 Hs.462598 13

RNA binding

protein binding

nucleus

cytoplasm

Golgi apparatus

polysomal ribosome

 
225182_at TMEM50B transmembrane protein 50B 21 -33743317 AL355685 21q22.11 Hs.433668 8

molecular_function

endoplasmic reticulum

plasma membrane

biological_process

integral to membrane

 
1563781_at LOC285949 hypothetical protein LOC285949 7   AK096687 7p15.1 Hs.561708 1    
229389_at -0.410 5.089 -3.485 3.263e-03 0.307 -1.603 ATG16L2 ATG16 autophagy related 16-like 2 (S. cerevisiae) 11 72203098 AA741058 11q13.4 Hs.653186 3

cytoplasm

autophagy

protein transport

 
1559083_x_at LOC284600 hypothetical protein LOC284600 1   AK056486 1p36.33 Hs.551839 2    
229983_at TIGD2 tigger transposable element derived 2 4 90252990 AI610112 4q22.1 Hs.58924 5

chromosome, centromeric region

DNA binding

nucleus

regulation of transcription

 
220745_at IL19 interleukin 19 1 205038837, 205068844 NM_013371 1q32.2 Hs.661017 35

cytokine activity

extracellular region

extracellular space

oxygen and reactive oxygen species metabolic process

apoptosis

induction of apoptosis

immune response

signal transduction

interleukin-6 biosynthetic process

Cytokine-cytokine receptor interaction

Jak-STAT signaling pathway

211057_at ROR1 receptor tyrosine kinase-like orphan receptor 1 1 64012277, 64012277 BC006374 1p32-p31 Hs.654491 13

nucleotide binding

transmembrane receptor protein tyrosine kinase activity

receptor activity

ATP binding

cytoplasm

plasma membrane

integral to plasma membrane

protein amino acid phosphorylation

transmembrane receptor protein tyrosine kinase signaling pathway

transferase activity

 
210201_x_at BIN1 bridging integrator 1 2 -127522077, -127522076 AF001383 2q14 Hs.193163 69

protein binding

nucleus

cytoplasm

multicellular organismal development

cell proliferation

actin cytoskeleton

regulation of endocytosis

cell differentiation

interspecies interaction between organisms

 
238662_at ATPBD4 ATP binding domain 4 15 -33599765, -33450461 BE884544 15q14 Hs.107196 4    
221355_at 0.476 5.177 3.641 2.365e-03 0.284 -1.330 CHRNG cholinergic receptor, nicotinic, gamma 2 233112680 NM_005199 2q33-q34 Hs.248101 17

nicotinic acetylcholine-activated cation-selective channel activity

ion channel activity

extracellular ligand-gated ion channel activity

plasma membrane

integral to plasma membrane

ion transport

muscle contraction

signal transduction

channel activity

acetylcholine receptor activity

cell junction

synapse

postsynaptic membrane

 
203194_s_at NUP98 nucleoporin 98kDa 11 -3689634, -3652815 AA527238 11p15.5 Hs.524750 78

protein import into nucleus, docking

kinetochore

transporter activity

protein binding

nucleus

nucleoplasm

DNA replication

nucleocytoplasmic transport

nuclear pore organization

protein transport

membrane

structural constituent of nuclear pore

Nup107-160 complex

Nup107-160 complex

interspecies interaction between organisms

mRNA transport

intracellular protein transmembrane transport

 
235504_at 0.438 4.434 2.190 4.454e-02 0.580 -3.809 GREM2 gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis) 1 -238719495 BE786990 1q43 Hs.98206 9

cytokine activity

extracellular region

extracellular region

extracellular space

BMP signaling pathway

 
225665_at ZAK sterile alpha motif and leucine zipper containing kinase AZK 2 173648810, 173648810 AI129320 2q24.2 Hs.444451 24

cell cycle checkpoint

DNA damage checkpoint

nucleotide binding

activation of MAPKK activity

magnesium ion binding

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

protein tyrosine kinase activity

ATP binding

nucleus

cytoplasm

response to stress

cell cycle

cell cycle arrest

protein kinase cascade

activation of JUN kinase activity

cell death

cell proliferation

response to radiation

transferase activity

cell differentiation

identical protein binding

positive regulation of apoptosis

MAPK signaling pathway

Tight junction

201082_s_at DCTN1 dynactin 1 (p150, glued homolog, Drosophila) 2 -74441789, -74441789 NM_004082 2p13 Hs.516111 74

spindle pole

motor activity

protein binding

cytoplasm

cytoskeleton

microtubule

mitosis

nervous system development

cell death

dynein complex

Huntington's disease

221778_at JHDM1D jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) 7 -139431014 BE217882 7q34 Hs.308710 3

protein binding

zinc ion binding

metal ion binding

 
215415_s_at LYST lysosomal trafficking regulator 1 -233890968 U70064 1q42.1-q42.2 Hs.532411 23

protein binding

cytoplasm

protein transport

microtubule cytoskeleton

leukocyte chemotaxis

melanosome organization

endosome to lysosome transport via multivesicular body sorting pathway

mast cell secretory granule organization

natural killer cell mediated cytotoxicity

defense response to bacterium

defense response to protozoan

pigmentation

defense response to virus

 
202257_s_at CD2BP2 CD2 (cytoplasmic tail) binding protein 2 16 -30269588, -30269588 NM_006110 16p11.2 Hs.202677 21

nuclear mRNA splicing, via spliceosome

protein binding

cytoplasm

 
201214_s_at PPP1R7 protein phosphatase 1, regulatory (inhibitor) subunit 7 2 241738574 NM_002712 2q37.3 Hs.36587 10

protein binding

nucleus

cytoplasm

biological_process

protein phosphatase type 1 regulator activity

enzyme regulator activity

 
228239_at FAM165B family with sequence similarity 165, member B 21 34669618 AA148789 21q22.12 Hs.656195 7

molecular_function

cellular_component

biological_process

membrane

integral to membrane

 
223281_s_at COX15 COX15 homolog, cytochrome c oxidase assembly protein (yeast) 10 -101458494 AF026850 10q24 Hs.28326 9

catalytic activity

cytochrome-c oxidase activity

mitochondrial respiratory chain

mitochondrial electron transport, cytochrome c to oxygen

protein complex assembly

heme a biosynthetic process

respiratory gaseous exchange

respiratory chain complex IV assembly

membrane

integral to membrane

mitochondrial part

cellular respiration

oxidation reduction

Oxidative phosphorylation

Porphyrin and chlorophyll metabolism

Metabolic pathways

39313_at WNK1 WNK lysine deficient protein kinase 1 12 732485 AB002342 12p13.3 Hs.709894 51

nucleotide binding

molecular_function

protein serine/threonine kinase activity

protein kinase inhibitor activity

protein binding

ATP binding

cytoplasm

cytoplasm

protein amino acid phosphorylation

ion transport

protein kinase cascade

biological_process

transferase activity

regulation of cellular process

 
204622_x_at NR4A2 nuclear receptor subfamily 4, group A, member 2 2 -156889189 NM_006186 2q22-q23 Hs.563344 76

transcription factor activity

steroid hormone receptor activity

nucleus

regulation of transcription, DNA-dependent

signal transduction

zinc ion binding

cellular response to extracellular stimulus

sequence-specific DNA binding

metal ion binding

response to protein stimulus

 
224078_at -0.221 6.931 -2.337 3.349e-02 0.552 -3.573 HIATL2 hippocampus abundant transcript-like 2 9 -98748147 BC005058 9q22.33 Hs.610084 3

transporter activity

transport

membrane

integral to membrane

 
229044_at NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 1 -144297851 AA284522 1q21.1 Hs.585066 4

magnesium ion binding

mitochondrion

hydrolase activity

manganese ion binding

 
201213_at PPP1R7 protein phosphatase 1, regulatory (inhibitor) subunit 7 2 241738574 AI090331 2q37.3 Hs.36587 10

protein binding

nucleus

cytoplasm

biological_process

protein phosphatase type 1 regulator activity

enzyme regulator activity

 
217858_s_at ARMCX3 armadillo repeat containing, X-linked 3 X 100764775, 100765006 NM_016607 Xq21.33-q22.2 Hs.592225 13

binding

membrane

integral to membrane

 
39549_at NPAS2 neuronal PAS domain protein 2 2 100803044 AI743090 2q11.2 Hs.156832 Hs.705895 23

transcription factor activity

signal transducer activity

nucleus

transcription factor complex

regulation of transcription, DNA-dependent

signal transduction

central nervous system development

circadian sleep/wake cycle

locomotor rhythm

positive regulation of transcription from RNA polymerase II promoter

rhythmic process

Hsp90 protein binding

Circadian rhythm - mammal

234291_s_at SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3 -45771944 AL389979 3p21.3 Hs.413095 5

neurotransmitter:sodium symporter activity

plasma membrane

integral to plasma membrane

neurotransmitter transport

amino acid transport

amino acid transmembrane transporter activity

symporter activity

apical plasma membrane

 
225351_at 0.435 7.218 2.562 2.148e-02 0.497 -3.202 FAM45A family with sequence similarity 45, member A 10 120853600 AI697488 10q25 Hs.434241 3    
220712_at C8orf60 chromosome 8 open reading frame 60 8   NM_024984 8q24.3   1    
238253_at WDR72 WD repeat domain 72 15 -51593229 AI733060 15q21.3 Hs.122125 4    
217883_at MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 2 -150134395 NM_015702 2q23.2 Hs.5324 7

mitochondrion

 
238051_x_at PWWP2B PWWP domain containing 2B 10 134060691 AI918314 10q26.3 Hs.527751 5    
205687_at UBFD1 ubiquitin family domain containing 1 16 23476362 NM_019116 16p12 Hs.3459 3    
210707_x_at PMS2L11 postmeiotic segregation increased 2-like 11 pseudogene 7 76448074 U38980 7q11.23 Hs.675888 5    
221676_s_at 0.514 5.968 3.475 3.335e-03 0.308 -1.622 CORO1C coronin, actin binding protein, 1C 12 -107563015 BC002342 12q24.1 Hs.330384 12

actin binding

phagocytosis

signal transduction

actin cytoskeleton

 
238054_at ADPRHL1 ADP-ribosylhydrolase like 1 13 -113124584, -113124260 AI243209 13q34 Hs.98669 4

magnesium ion binding

ADP-ribosylarginine hydrolase activity

hydrolase activity

protein amino acid de-ADP-ribosylation

 
228063_s_at 0.465 5.957 2.187 4.480e-02 0.581 -3.814 NAP1L5 nucleosome assembly protein 1-like 5 4 -89836096 AW025330 4q21-q22 4q22.1 Hs.12554 8

protein binding

nucleus

nucleosome assembly

 
214668_at C13orf1 chromosome 13 open reading frame 1 13 -49384842 BG532405 13q14 Hs.44235 11    
233947_s_at LOC255480 hypothetical protein LOC255480 12   U47671 12q24.21 Hs.567915 1    
219618_at IRAK4 interleukin-1 receptor-associated kinase 4 12 42439013 NM_016123 12q12 Hs.138499 49

nucleotide binding

magnesium ion binding

cytokine production

protein serine/threonine kinase activity

interleukin-1 receptor binding

protein binding

ATP binding

cytosol

protein amino acid phosphorylation

signal transduction

I-kappaB kinase/NF-kappaB cascade

transferase activity

cytokine-mediated signaling pathway

Apoptosis

Toll-like receptor signaling pathway

Neurotrophin signaling pathway

228633_s_at CNTROB centrobin, centrosomal BRCA2 interacting protein 17 7776197 AI668799 17p13.1 Hs.348012 8

cytokinesis

centriole

cell cycle

centriole replication

protein domain specific binding

centrosome separation

 
207685_at CRYBB3 crystallin, beta B3 22 23925824 NM_004076 22q11.2-q12.1 22q11.23 Hs.533022 12

structural constituent of eye lens

protein binding

visual perception

 
1554705_at SCARA5 scavenger receptor class A, member 5 (putative) 8 -27783668 BC033153 8p21.1 Hs.591833 6

receptor activity

scavenger receptor activity

iron ion binding

protein binding

plasma membrane

integral to plasma membrane

ion transport

cellular iron ion homeostasis

endocytosis

cell surface

cellular response to heat

iron ion transmembrane transport

protein homotrimerization

ferritin receptor activity

 
225702_at C8orf76 chromosome 8 open reading frame 76 8 -124301411 AA973041 8q24.13 Hs.521800 4

binding

 
203099_s_at CDYL chromodomain protein, Y-like 6 4651391, 4721678, 4781330, 4835224 AF081258 6p25.1 Hs.269092 8

chromatin

chromatin binding

histone acetyltransferase activity

nucleus

chromatin assembly or disassembly

spermatogenesis

metabolic process

acyltransferase activity

transferase activity

regulation of transcription

 
219002_at FASTKD1 FAST kinase domains 1 2 -170094508 NM_024622 2q31 Hs.529276 6

protein kinase activity

ATP binding

apoptosis

 
204478_s_at RABIF RAB interacting factor 1 -201114708 NM_002871 1q32-q41 Hs.90875 13

guanyl-nucleotide exchange factor activity

membrane fusion

small GTPase mediated signal transduction

zinc ion binding

protein transport

metal ion binding

 
224699_s_at ESYT2 extended synaptotagmin-like protein 2 7 -158216449 BE385892 7q36.3 Hs.490795 10

plasma membrane

integral to membrane

 
224595_at SLC44A1 solute carrier family 44, member 1 9 107046749 AK022549 9q31.2 Hs.573495 14

transport

choline transmembrane transporter activity

choline transport

membrane

integral to membrane

 
239443_at PCDHB6 protocadherin beta 6 5 140510022 AI821557 5q31 Hs.283085 7

calcium ion binding

protein binding

plasma membrane

integral to plasma membrane

cell adhesion

homophilic cell adhesion

synaptic transmission

synaptogenesis

calcium-dependent cell-cell adhesion

 
220488_s_at BCAS3 breast carcinoma amplified sequence 3 17 56109953 NM_017679 17q23 Hs.655028 12

nucleus

 
230430_at ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 9 -139062373 AW134837 9q34 Hs.123036 14

magnesium ion binding

calcium ion binding

membrane

integral to membrane

hydrolase activity

Purine metabolism

227810_at ZNF558 zinc finger protein 558 19 -8781381 AW119060 19p13.2 Hs.659797 4

DNA binding

protein binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
222692_s_at 0.455 5.378 2.717 1.577e-02 0.459 -2.942 FNDC3B fibronectin type III domain containing 3B 3 173240111, 173241037 BF444916 3q26.31 Hs.159430 9

endoplasmic reticulum

membrane

integral to membrane

 
1553039_a_at -0.239 7.101 -2.714 1.585e-02 0.459 -2.946 ASB10 ankyrin repeat and SOCS box-containing 10 7 -150503717, -150503717 NM_080871 7q36.1 Hs.647081 6

intracellular signaling cascade

modification-dependent protein catabolic process

 
224431_s_at SUV420H2 suppressor of variegation 4-20 homolog 2 (Drosophila) 19 60543032 BC005842 19q13.42 Hs.590982 6

protein binding

nucleus

chromosome

methyltransferase activity

chromatin modification

transferase activity

histone-lysine N-methyltransferase activity

regulation of transcription

Lysine degradation

239890_s_at SERP2 stress-associated endoplasmic reticulum protein family member 2 13 43845977 BG054503 13q14.11 Hs.377972 4

endoplasmic reticulum

protein transport

membrane

integral to membrane

intracellular protein transmembrane transport

 
225798_at JAZF1 JAZF zinc finger 1 7 -27836717 AL047908 7p15.2-p15.1 Hs.368944 39

negative regulation of transcription from RNA polymerase II promoter

nucleic acid binding

transcription corepressor activity

intracellular

nucleus

zinc ion binding

transcriptional repressor complex

regulation of transcription

metal ion binding

 
206907_at TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 19 6482009 NM_003811 19p13.3 Hs.1524 32

cytokine activity

tumor necrosis factor receptor binding

extracellular space

apoptosis

immune response

signal transduction

cell-cell signaling

cell proliferation

membrane

integral to membrane

Cytokine-cytokine receptor interaction

215245_x_at 0.393 6.486 2.324 3.437e-02 0.553 -3.595 FMR1 fragile X mental retardation 1 X 146801200 AA830884 Xq27.3 Hs.103183 211

mRNA binding

protein binding

soluble fraction

nucleus

nucleoplasm

nucleolus

cytoplasm

transport

polysomal ribosome

mRNA transport

 
214884_at -0.349 3.183 -3.993 1.148e-03 0.231 -0.717 MCF2 MCF.2 cell line derived transforming sequence X -138491595, -138491595 AL033403 Xq27 Hs.387262 24

guanyl-nucleotide exchange factor activity

Rho guanyl-nucleotide exchange factor activity

protein binding

intracellular

membrane fraction

cytoplasm

cytosol

cytoskeleton

intracellular signaling cascade

membrane

regulation of Rho protein signal transduction

 
1552790_a_at SEC62 SEC62 homolog (S. cerevisiae) 3 171167273 NM_153039 3q26.2 Hs.622596 10

receptor activity

endoplasmic reticulum

cytoskeleton

cotranslational protein targeting to membrane

protein transporter activity

protein transport

membrane

integral to membrane

intracellular protein transmembrane transport

 
1554610_at ANKMY1 ankyrin repeat and MYND domain containing 1 2 -241067511 BC033495 2q37.3 Hs.656615 4

zinc ion binding

metal ion binding

 
226222_at KIAA1432 KIAA1432 9 5619326, 5646582 AB037853 9p24.1 Hs.211520 5

membrane

integral to membrane

 
211441_x_at -0.296 3.690 -3.059 7.847e-03 0.383 -2.350 CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 7 99263571 AF280113 7q21.1 Hs.306220 Hs.654391 Hs.695915 17

endoplasmic reticulum

microsome

electron carrier activity

membrane

heme binding

metal ion binding

oxidation reduction

aromatase activity

gamma-Hexachlorocyclohexane degradation

Linoleic acid metabolism

Retinol metabolism

Metabolism of xenobiotics by cytochrome P450

Drug metabolism - cytochrome P450

Drug metabolism - other enzymes

Metabolic pathways

208923_at 0.437 8.287 2.227 4.144e-02 0.572 -3.749 CYFIP1 cytoplasmic FMR1 interacting protein 1 15 20444124, 20507195 BC005097 15q11 Hs.26704 13

ruffle

protein binding

protein binding

cytoplasm

multicellular organismal development

nervous system development

regulation of cell shape

synaptosome

lamellipodium

lamellipodium assembly

cell junction

cell differentiation

ruffle organization

synapse

Rac GTPase binding

perinuclear region of cytoplasm

axon extension

actin filament binding

Regulation of actin cytoskeleton

209787_s_at HMGN4 high mobility group nucleosomal binding domain 4 6 26646550 BC001282 6p21.3 Hs.236774 6

chromatin

DNA binding

nucleus

 
229767_at TBCD tubulin folding cofactor D 17 78303228 AA012848 17q25.3 Hs.464391 18

binding

microtubule

protein folding

chaperone binding

 
237033_at -0.262 4.818 -2.249 3.974e-02 0.568 -3.715 FAM159A family with sequence similarity 159, member A 1 52871653 AI202832 1p32.3 Hs.424589 2

membrane

integral to membrane

 
222810_s_at RASAL2 RAS protein activator like 2 1 176329486, 176577228 BF435513 1q24 Hs.549729 Hs.715627 11

Ras GTPase activator activity

intracellular

signal transduction

regulation of small GTPase mediated signal transduction

 
1569335_a_at STRA6 stimulated by retinoic acid gene 6 homolog (mouse) 15 -72273783, -72258862, -72258862, -72258862 BC015881 15q24.1 Hs.24553 13

receptor activity

plasma membrane

transport

integral to membrane

protein complex

 
202243_s_at PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 1 149638664 NM_002796 1q21 Hs.89545 46

threonine-type endopeptidase activity

nucleus

cytoplasm

centrosome

cytosol

proteasome core complex

cytoskeleton

peptidase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

proteolysis involved in cellular protein catabolic process

Proteasome

222862_s_at AK5 adenylate kinase 5 1 77520329, 77520874 BG169832 1p31 Hs.559718 5

nucleotide binding

adenylate kinase activity

ATP binding

cytoplasm

cytosol

cytosol

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

ADP biosynthetic process

dADP biosynthetic process

pyrimidine ribonucleotide biosynthetic process

transferase activity

nucleoside kinase activity

ATP metabolic process

Purine metabolism

Metabolic pathways

208102_s_at PSD pleckstrin and Sec7 domain containing 10 -104152365 NM_002779 10q24 Hs.154658 5

signal transducer activity

ARF guanyl-nucleotide exchange factor activity

cellular_component

intracellular

signal transduction

regulation of ARF protein signal transduction

Endocytosis

210482_x_at 0.340 5.612 2.498 2.444e-02 0.513 -3.310 MAP2K5 mitogen-activated protein kinase kinase 5 15 65622074 U71087 15q23 Hs.114198 29

MAPKKK cascade

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein tyrosine kinase activity

protein binding

ATP binding

spindle

protein amino acid phosphorylation

signal transduction

heart development

transferase activity

MAPK signaling pathway

Gap junction

Neurotrophin signaling pathway

209553_at -0.440 7.060 -2.587 2.046e-02 0.495 -3.161 VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 3 186012624 BC001001 3q27.2 Hs.269263 6

protein binding

zinc ion binding

metal ion binding

 
234268_at SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 12 -38435091 AK000182 12q12 Hs.558595 5

transporter activity

membrane

integral to membrane

substrate-specific transmembrane transporter activity

transmembrane transport

 
226968_at KIF1B kinesin family member 1B 1 10193350, 10193350 AK023184 1p36.2 Hs.97858 33

nucleotide binding

microtubule motor activity

protein binding

ATP binding

cytoplasm

mitochondrion

cytoskeleton

microtubule

microtubule associated complex

microtubule-based movement

nerve-nerve synaptic transmission

neuromuscular synaptic transmission

anterograde axon cargo transport

ATPase activity

kinesin binding

cytoplasmic vesicle membrane

cytoskeleton-dependent intracellular transport

cytoplasmic vesicle

 
215285_s_at 0.407 4.504 3.005 8.777e-03 0.394 -2.445 PHTF1 putative homeodomain transcription factor 1 1 -114041346 AA927671 1p13 Hs.655824 9

transcription factor activity

nucleus

regulation of transcription

 
1558945_s_at CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 19 -13178256 BC042451 19p13.2-p13.1 Hs.501632 126

voltage-gated ion channel activity

voltage-gated calcium channel activity

voltage-gated calcium channel activity

calcium ion binding

protein binding

nucleus

cytoplasm

plasma membrane

plasma membrane

voltage-gated calcium channel complex

ion transport

calcium ion transport

elevation of cytosolic calcium ion concentration

cell death

integral to membrane

syntaxin binding

cell projection

MAPK signaling pathway

Calcium signaling pathway

Long-term depression

Taste transduction

Type II diabetes mellitus

209385_s_at PROSC proline synthetase co-transcribed homolog (bacterial) 8 37739258 AL136616 8p11.2 Hs.304792 Hs.608177 8

intracellular

cytoplasm

 
230194_at -0.452 7.658 -3.138 6.676e-03 0.367 -2.213 LRPPRC leucine-rich PPR-motif containing 2 -43966866 AI341076 2p21 Hs.368084 15

condensed nuclear chromosome

DNA binding

single-stranded DNA binding

RNA binding

protein binding

nucleus

nuclear inner membrane

nuclear outer membrane

nucleoplasm

cytoplasm

mitochondrion

cytoskeleton

transport

microtubule binding

membrane

mitochondrial nucleoid

regulation of transcription

mitochondrion transport along microtubule

perinuclear region of cytoplasm

beta-tubulin binding

actin filament binding

mRNA transport

 
212563_at BOP1 block of proliferation 1 8 -145456863 BG491842 8q24.3 Hs.535901 Hs.645279 21

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

protein binding

nucleus

nucleoplasm

nucleolus

rRNA processing

cell proliferation

ribonucleoprotein complex

regulation of cell cycle

PeBoW complex

 
208257_x_at PSG1 pregnancy specific beta-1-glycoprotein 1 19 -48063197 NM_006905 19q13.2 Hs.709192 27

extracellular region

female pregnancy

 
238539_at HPS3 Hermansky-Pudlak syndrome 3 3 150330060 BG163294 3q24 Hs.558314 Hs.591311 14

cytoplasm

organelle organization

pigmentation

 
214294_at KIAA0485 hypothetical LOC57235     AI122905   Hs.604754 1    
200764_s_at 0.252 6.736 2.137 4.926e-02 0.590 -3.891 CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 5 138117005 AI826881 5q31 Hs.534797 Hs.656653 70

structural molecule activity

protein binding

cytoplasm

plasma membrane

adherens junction

cell adhesion

actin cytoskeleton

vinculin binding

cell junction

apical junction assembly

cadherin binding

Adherens junction

Tight junction

Leukocyte transendothelial migration

Pathways in cancer

Endometrial cancer

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

218712_at C1orf109 chromosome 1 open reading frame 109 1 -37919828 NM_017850 1p34.3 Hs.272673 3    
206632_s_at 0.254 2.185 2.391 3.015e-02 0.540 -3.486 APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 22 37708350 NM_004900 22q13.1-q13.2 Hs.226307 18

RNA binding

cellular_component

biological_process

zinc ion binding

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

metal ion binding

Atrazine degradation

222218_s_at -0.358 5.490 -3.411 3.800e-03 0.319 -1.733 PILRA paired immunoglobin-like type 2 receptor alpha 7 99809003 AJ400843 7q22.1 Hs.444407 10

receptor activity

protein binding

extracellular region

plasma membrane

signal transduction

integral to membrane

interspecies interaction between organisms

 
1554787_at -0.231 4.185 -2.243 4.023e-02 0.569 -3.725 C9orf96 chromosome 9 open reading frame 96 9 135233104 BC036504 9q34.2 Hs.159448 5

nucleotide binding

protein kinase activity

ATP binding

protein amino acid phosphorylation

 
215437_x_at BAZ2A bromodomain adjacent to zinc finger domain, 2A 12 -55275646 BE513659 12q24.3-qter Hs.314263 11

chromatin silencing at rDNA

DNA binding

RNA binding

protein binding

nucleus

chromatin silencing complex

nucleolus

nucleolus organizer region

DNA methylation

chromatin remodeling

regulation of transcription, DNA-dependent

zinc ion binding

histone deacetylation

transcription regulator activity

rDNA heterochromatin

metal ion binding

histone acetyl-lysine binding

 
226603_at 0.528 5.327 2.782 1.382e-02 0.441 -2.830 SAMD9L sterile alpha motif domain containing 9-like 7 -92597303 BE966604 7q21.2 Hs.489118 4    
215992_s_at RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 4 160408447 AL117397 4q32.1 Hs.113912 14

MAPKKK cascade

signal transducer activity

guanyl-nucleotide exchange factor activity

calcium ion binding

protein binding

intracellular

plasma membrane

integral to plasma membrane

Rap guanyl-nucleotide exchange factor activity

cAMP-mediated signaling

diacylglycerol binding

Rap GTPase activator activity

regulation of small GTPase mediated signal transduction

MAPK signaling pathway

230228_at LOC284297 hypothetical LOC284297 19 60691681 W94546 19q13.42 Hs.554182 2

scavenger receptor activity

extracellular region

membrane

 
218652_s_at PIGG phosphatidylinositol glycan anchor biosynthesis, class G 4 482988 NM_017733 4p16.3 Hs.7099 8

protein binding

endoplasmic reticulum

endoplasmic reticulum membrane

metabolic process

membrane

integral to membrane

preassembly of GPI anchor in ER membrane

transferase activity

phosphotransferase activity, for other substituted phosphate groups

CP2 mannose-ethanolamine phosphotransferase activity

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

200907_s_at PALLD palladin, cytoskeletal associated protein 4 169654791 AU157932 4q32.3 Hs.151220 40

actin binding

protein binding

nucleus

cytoplasm

cytoskeleton

actin filament

cytoskeleton organization

muscle alpha-actinin binding

 
213864_s_at NAP1L1 nucleosome assembly protein 1-like 1 12 -74724938 AI985751 12q21.2 Hs.524599 Hs.695185 17

protein binding

nucleus

chromatin assembly complex

DNA replication

nucleosome assembly

positive regulation of cell proliferation

melanosome

 
218769_s_at ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 5 -72883918 NM_023039 5q12-q13 Hs.239154 6

protein binding

membrane fraction

cytoplasm

cytosol

cytoskeleton

biological_process

membrane

low-density lipoprotein binding

 
234665_x_at HHLA3 HERV-H LTR-associating 3 1 70593080, 70593080 AF126163 1p31.1 Hs.142245 5

protein binding

 
1552660_a_at C5orf22 chromosome 5 open reading frame 22 5 31568129 BC021215 5p13.3 Hs.519246 7    
235353_at KIAA0746 KIAA0746 protein 4 -25358146 AI887866 4p15.2 Hs.479384 5

binding

membrane

integral to membrane

 
243017_at LOC158572 hypothetical LOC158572 X -49528067 AA032156 Xp11.23 Hs.408191 3    
216436_at PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 3 -131880467 AK025026 3q22.1 Hs.149032 9

nucleotide binding

protein serine/threonine kinase activity

protein tyrosine kinase activity

ATP binding

cellular_component

cytosol

protein amino acid phosphorylation

transferase activity

Regulation of autophagy

227022_at 0.568 5.800 2.961 9.588e-03 0.405 -2.520 GNPDA2 glucosamine-6-phosphate deaminase 2 4 -44398924 AI817388 4p12 Hs.21398 6

glucosamine-6-phosphate deaminase activity

cytoplasm

carbohydrate metabolic process

N-acetylglucosamine metabolic process

hydrolase activity

Amino sugar and nucleotide sugar metabolism

Metabolic pathways

219335_at 0.577 5.634 2.576 2.089e-02 0.497 -3.179 ARMCX5 armadillo repeat containing, X-linked 5 X 101740813 NM_022838 Xq22.1-q22.3 Hs.522729 5

binding

 
209861_s_at METAP2 methionyl aminopeptidase 2 12 94391952 U13261 12q22 Hs.444986 35

aminopeptidase activity

cytoplasm

proteolysis

peptidase activity

metalloexopeptidase activity

cellular process

protein processing

peptidyl-methionine modification

N-terminal protein amino acid modification

metal ion binding

cobalt ion binding

 
230292_at 0.452 6.050 2.624 1.901e-02 0.488 -3.099 LOC100131993 similar to hCG2020760 13   AA868809 13q14.2 Hs.709358      
216248_s_at NR4A2 nuclear receptor subfamily 4, group A, member 2 2 -156889189 S77154 2q22-q23 Hs.563344 76

transcription factor activity

steroid hormone receptor activity

nucleus

regulation of transcription, DNA-dependent

signal transduction

zinc ion binding

cellular response to extracellular stimulus

sequence-specific DNA binding

metal ion binding

response to protein stimulus

 
1569332_at C3orf66 chromosome 3 open reading frame 66 3 110379701 BC022563 3q13.13 Hs.618669 2    
225524_at 0.715 6.136 3.982 1.172e-03 0.231 -0.734 ANTXR2 anthrax toxin receptor 2 4 -81117685, -81041796 AU152178 4q21.21 Hs.162963 22

receptor activity

protein binding

extracellular region

endoplasmic reticulum

plasma membrane

integral to membrane

metal ion binding

 
222436_s_at 0.223 8.492 2.341 3.322e-02 0.552 -3.566 VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae) 2 -86584063 AF219226 2p24.3-p24.1 Hs.591582 25

protein binding

cytoplasm

endosome

cytosol

cell cycle

protein transport

membrane

late endosome membrane

cell division

Endocytosis

235931_at 0.445 3.428 2.200 4.366e-02 0.578 -3.792 FAM119A family with sequence similarity 119, member A 2 -208182083, -208182083 AI332764 2q33.3 Hs.664764 2

membrane

integral to membrane

 
211006_s_at 1.741 6.748 2.428 2.801e-02 0.529 -3.424 KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1 20 -47421911 L02840 20q13.2 Hs.84244 28

voltage-gated ion channel activity

voltage-gated potassium channel activity

protein binding

ion transport

potassium ion transport

voltage-gated potassium channel complex

membrane

integral to membrane

potassium ion binding

Taste transduction

1565583_at ZSCAN5A zinc finger and SCAN domain containing 5A 19 -61424490 AW469591 19q13.43 Hs.177688 3

transcription factor activity

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
209652_s_at PGF placental growth factor 14 -74478290 BC001422 14q24-q31 Hs.252820 79

angiogenesis

extracellular region

signal transduction

cell-cell signaling

multicellular organismal development

growth factor activity

heparin binding

positive regulation of cell proliferation

membrane

cell differentiation

mTOR signaling pathway

Focal adhesion

Pathways in cancer

Renal cell carcinoma

Pancreatic cancer

Bladder cancer

217842_at LUC7L2 LUC7-like 2 (S. cerevisiae) 7 138695173 NM_016019 7q34 Hs.718441 16

zinc ion binding

enzyme binding

metal ion binding

 
213857_s_at CD47 CD47 molecule 3 -109244630 BG230614 3q13.1-q13.2 Hs.446414 68

protein binding

plasma membrane

plasma membrane

integral to plasma membrane

cell adhesion

integrin-mediated signaling pathway

positive regulation of cell proliferation

positive regulation of cell-cell adhesion

positive regulation of T cell activation

thrombospondin receptor activity

ECM-receptor interaction

243900_at WDR38 WD repeat domain 38 9 126655575 AI190548 9q33.3 Hs.343383 1    
203674_at HELZ helicase with zinc finger 17 -62497015 NM_014877 17q24.2 Hs.370140 Hs.569824 Hs.596366 8

nucleotide binding

nucleic acid binding

helicase activity

ATP binding

nucleus

zinc ion binding

hydrolase activity

metal ion binding

 
232940_s_at MLL3 myeloid/lymphoid or mixed-lineage leukemia 3 7 -151462942 AK025911 7q36.1 Hs.647120 21

DNA binding

protein binding

nucleus

regulation of transcription, DNA-dependent

intracellular signaling cascade

methyltransferase activity

zinc ion binding

chromatin modification

transferase activity

histone-lysine N-methyltransferase activity

metal ion binding

 
203167_at TIMP2 TIMP metallopeptidase inhibitor 2 17 -74360653 NM_003255 17q25 Hs.633514 168

enzyme inhibitor activity

integrin binding

protein binding

extracellular region

basement membrane

enzyme activator activity

metalloendopeptidase inhibitor activity

negative regulation of cell proliferation

cell surface

regulation of cAMP metabolic process

regulation of MAPKKK cascade

regulation of neuron differentiation

 
200830_at PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 3 185499715 NM_002808 3q27.1 Hs.518464 45

proteasome complex

protein binding

cytosol

proteasome regulatory particle

enzyme regulator activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

206409_at -0.262 4.127 -3.297 4.809e-03 0.339 -1.933 TIAM1 T-cell lymphoma invasion and metastasis 1 21 -31412606 NM_003253 21q22.1 21q22.11 Hs.517228 49

receptor signaling protein activity

guanyl-nucleotide exchange factor activity

Rho guanyl-nucleotide exchange factor activity

protein binding

phospholipid binding

intracellular

plasma membrane

small GTPase mediated signal transduction

regulation of Rho protein signal transduction

ephrin receptor binding

ephrin receptor signaling pathway

positive regulation of axonogenesis

Chemokine signaling pathway

Regulation of actin cytoskeleton

204592_at -0.355 4.637 -2.403 2.945e-02 0.536 -3.466 DLG4 discs, large homolog 4 (Drosophila) 17 -7033935, -7033933 NM_001365 17p13.1 Hs.463928 119

cytoplasm

plasma membrane

protein complex assembly

signal transduction

synaptic transmission

nervous system development

learning

protein C-terminus binding

postsynaptic density

synaptic vesicle maturation

synaptosome

cell junction

cortical cytoskeleton

extrinsic to internal side of plasma membrane

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex

synapse

postsynaptic membrane

regulation of long-term neuronal synaptic plasticity

Huntington's disease

225144_at BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 2 202949294 AI457436 2q33-q34 Hs.471119 106

nucleotide binding

magnesium ion binding

mesoderm formation

negative regulation of systemic arterial blood pressure

protein serine/threonine kinase activity

receptor activity

transforming growth factor beta receptor activity

protein binding

ATP binding

plasma membrane

plasma membrane

integral to plasma membrane

caveola

transcription from RNA polymerase II promoter

protein amino acid phosphorylation

cellular response to starvation

anterior/posterior pattern formation

regulation of lung blood pressure

regulation of lung blood pressure

transferase activity

manganese ion binding

positive regulation of bone mineralization

BMP signaling pathway

BMP signaling pathway

BMP signaling pathway

BMP signaling pathway

regulation of cell proliferation

positive regulation of osteoblast differentiation

negative regulation of vasoconstriction

vascular endothelial growth factor receptor signaling pathway

lung alveolus development

Cytokine-cytokine receptor interaction

TGF-beta signaling pathway

1564709_at LOC286238 hypothetical protein LOC286238 9 -90451913 AK098532 9q22.1 Hs.434185 1    
214733_s_at YIPF1 Yip1 domain family, member 1 1 -54089993 AL031427 1p33-p32.1 Hs.11923 9

membrane

integral to membrane

transport vesicle

 
226324_s_at -0.244 5.946 -2.848 1.210e-02 0.426 -2.717 IFT172 intraflagellar transport 172 homolog (Chlamydomonas) 2 -27520743 AB033005 2p23.3 Hs.127401 4

neural tube formation

protein binding

cilium

smoothened signaling pathway

multicellular organismal development

determination of left/right symmetry

dorsal/ventral pattern formation

protein processing

cilium assembly

 
204105_s_at 0.501 4.360 2.681 1.694e-02 0.468 -3.002 NRCAM neuronal cell adhesion molecule 7 -107575317, -107575317 NM_005010 7q31.1-q31.2 Hs.21422 29

neuron migration

protein binding

plasma membrane

integral to plasma membrane

axonal fasciculation

synaptogenesis

central nervous system development

external side of plasma membrane

cell-cell adhesion

ankyrin binding

regulation of axon extension

neuron projection

clustering of voltage-gated sodium channels

positive regulation of neuron differentiation

Cell adhesion molecules (CAMs)

231995_at C9orf82 chromosome 9 open reading frame 82 9 -26830682 AF131768 9p21.2 Hs.178357 10    
201899_s_at UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog) X 118592526, 118598325 NM_003336 Xq24-q25 Hs.379466 16

nucleotide binding

chromatin

ubiquitin-protein ligase activity

ATP binding

postreplication repair

ubiquitin-dependent protein catabolic process

response to DNA damage stimulus

positive regulation of cell proliferation

response to UV

ligase activity

ubiquitin protein ligase binding

histone H2A ubiquitination

post-translational protein modification

regulation of protein metabolic process

protein autoubiquitination

Ubiquitin mediated proteolysis

226313_at C10orf35 chromosome 10 open reading frame 35 10 71060008 H49529 10q22.1 Hs.522992 5

protein binding

membrane

integral to membrane

 
238681_at GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 17 54652615 R46180 17q22 Hs.631744 6

glycerol metabolic process

lipid metabolic process

glycerophosphodiester phosphodiesterase activity

membrane

integral to membrane

hydrolase activity

 
228235_at 0.814 4.217 2.594 2.016e-02 0.492 -3.149 MGC16121 hypothetical protein MGC16121 X -133505073 BE048571 Xq26.3 Hs.416379 Hs.656866 2    
208777_s_at PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 17 27795614 AF001212 17q11.2 Hs.655396 41

proteasome complex

protein binding

cytosol

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

221172_at C7orf69 chromosome 7 open reading frame 69 7 47801413 NM_025031 7p12.3 Hs.287647 2

extracellular region

 
206180_x_at ZNF747 zinc finger protein 747 16 -30450279 NM_023931 16p11.2 Hs.592032 3

nucleic acid binding

intracellular

regulation of transcription, DNA-dependent

 
228186_s_at 0.700 8.382 3.488 3.241e-03 0.306 -1.598 RSPO3 R-spondin 3 homolog (Xenopus laevis) 6 127481740 BF589322 6q22.33 Hs.135254 10

extracellular region

heparin binding

Wnt receptor signaling pathway

response to stimulus

 
1554584_at LRRC48 leucine rich repeat containing 48 17 17816851, 17816851 BC040276 17p11.2 Hs.579264 11

protein binding

cytoplasm

 
206109_at FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 19 -53943079 NM_000148 19q13.3 Hs.69747 30

membrane fraction

Golgi apparatus

integral to plasma membrane

carbohydrate metabolic process

protein amino acid glycosylation

galactoside 2-alpha-L-fucosyltransferase activity

fucosyltransferase activity

membrane

transferase activity, transferring glycosyl groups

L-fucose catabolic process

Glycosphingolipid biosynthesis - lacto and neolacto series

Glycosphingolipid biosynthesis - globo series

Metabolic pathways

209690_s_at DOK4 docking protein 4 16 -56063370 BF591163 16q21 Hs.279832 11

MAPKKK cascade

transmembrane receptor protein tyrosine kinase signaling protein activity

insulin receptor binding

transmembrane receptor protein tyrosine kinase signaling pathway

nervous system development

 
225701_at AKNA AT-hook transcription factor 9 -116136254 AK024431 9q32 Hs.494895 5

DNA binding

nucleus

regulation of transcription

 
1560219_at -0.310 5.018 -3.350 4.312e-03 0.328 -1.841 ASB3 ankyrin repeat and SOCS box-containing 3 2 -53750621 AI076068 2p16-p14 Hs.40763 10

intracellular signaling cascade

modification-dependent protein catabolic process

 
225818_s_at TBRG1 transforming growth factor beta regulator 1 11 123997951 BG286461 11q24.2 Hs.436410 11

DNA binding

protein binding

nucleus

DNA replication

cell cycle

cell cycle arrest

negative regulation of cell proliferation

nucleolus to nucleoplasm transport

protein stabilization

 
221166_at FGF23 fibroblast growth factor 23 12 -4347653 NM_020638 12p13.3 Hs.287370 83

extracellular region

extracellular region

extracellular space

growth factor activity

fibroblast growth factor receptor signaling pathway

cell differentiation

regulation of bone mineralization

cellular phosphate ion homeostasis

MAPK signaling pathway

Regulation of actin cytoskeleton

Pathways in cancer

Melanoma

233988_x_at SCUBE1 signal peptide, CUB domain, EGF-like 1 22 -41929173 Z82214 22q13 Hs.133995 7

calcium ion binding

extracellular region

extracellular space

plasma membrane

inflammatory response

adult heart development

blood coagulation

post-embryonic development

external side of plasma membrane

extrinsic to plasma membrane

identical protein binding

endothelial cell differentiation

protein heterodimerization activity

protein homooligomerization

 
241433_at RCOR3 REST corepressor 3 1 209499330, 209499330, 209499911 AI023806 1q32.2 Hs.356399 10

DNA binding

protein binding

nucleus

nucleolus

cytoplasm

regulation of transcription

 
223675_s_at VEZT vezatin, adherens junctions transmembrane protein 12 94135652 AF216644 12q22 Hs.24135 8

acrosomal vesicle

nucleus

plasma membrane

adherens junction

integral to membrane

cell junction

 
1569111_at SOX13 SRY (sex determining region Y)-box 13 1 202308868 BC040649 1q32 Hs.201671 19

transcription factor activity

nucleus

anatomical structure morphogenesis

sequence-specific DNA binding

regulation of transcription

 
225113_at AGPS alkylglycerone phosphate synthase 2 177965716 BF688144 2q31.2 Hs.516543 19

peroxisome

peroxisomal membrane

cytosol

alkylglycerone-phosphate synthase activity

lipid biosynthetic process

membrane

oxidoreductase activity

transferase activity

FAD binding

Ether lipid metabolism

Metabolic pathways

219516_at TRPV4 transient receptor potential cation channel, subfamily V, member 4 12 -108705276 NM_021625 12q24.1 Hs.506713 50

calcium channel activity

calcium ion binding

calmodulin binding

plasma membrane

ion transport

calcium ion transport

calcium ion transport

cellular calcium ion homeostasis

cell volume homeostasis

elevation of cytosolic calcium ion concentration

osmosensory signaling pathway

response to mechanical stimulus

integral to membrane

identical protein binding

 
212373_at FEM1B fem-1 homolog b (C. elegans) 15 66357194 AW139179 15q22 Hs.362733 9

ubiquitin-protein ligase activity

death receptor binding

death receptor binding

cellular_component

cytoplasm

induction of apoptosis

modification-dependent protein catabolic process

regulation of apoptosis

regulation of ubiquitin-protein ligase activity

 
206417_at -0.684 5.457 -2.918 1.048e-02 0.418 -2.596 CNGA1 cyclic nucleotide gated channel alpha 1 4 -47632750, -47632750 NM_000087 4p12-cen Hs.1323 15

nucleotide binding

photoreceptor outer segment

ion channel activity

membrane fraction

cytoplasm

integral to plasma membrane

ion transport

spermatogenesis

visual perception

membrane

intracellular cyclic nucleotide activated cation channel complex

cGMP binding

response to stimulus

 
207142_at KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3 2 155263338 NM_002239 2q24.1 Hs.591606 24

voltage-gated ion channel activity

protein binding

ion transport

potassium ion transport

voltage-gated potassium channel complex

external side of plasma membrane

G-protein activated inward rectifier potassium channel activity

membrane

integral to membrane

T-tubule

potassium ion binding

 
222760_at ZNF703 zinc finger protein 703 8 37672458 BG290193 8p11.23 Hs.288042 5

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
1554638_at ZFYVE16 zinc finger, FYVE domain containing 16 5 79739593 BC032227 5q14 Hs.482660 Hs.660410 15

protein binding

phosphatidylinositol binding

cytoplasm

protein targeting to lysosome

signal transduction

zinc ion binding

protein transporter activity

membrane

vesicle organization

endosome transport

regulation of endocytosis

BMP signaling pathway

early endosome membrane

metal ion binding

TGF-beta signaling pathway

214889_at 2.028 5.527 5.187 1.057e-04 0.162 1.266 FAM149A family with sequence similarity 149, member A 4 187302988, 187307320 AL080065 4q35.1 Hs.357025 3    
205759_s_at SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 19 53747240, 53770804 NM_004605 19q13.3 Hs.369331 29

alcohol sulfotransferase activity

protein binding

cytoplasm

cytosol

lipid metabolic process

steroid metabolic process

transferase activity

steroid sulfotransferase activity

Androgen and estrogen metabolism

Sulfur metabolism

208671_at SERINC1 serine incorporator 1 6 -122806191 AF164794 6q22.31 Hs.146668 9

endoplasmic reticulum

endoplasmic reticulum membrane

plasma membrane

lipid metabolic process

phosphatidylserine metabolic process

sphingolipid metabolic process

phospholipid biosynthetic process

L-serine transmembrane transporter activity

L-serine transport

integral to membrane

positive regulation of transferase activity

 
201485_s_at RCN2 reticulocalbin 2, EF-hand calcium binding domain 15 75011016 BC004892 15q23 Hs.79088 10

calcium ion binding

protein binding

endoplasmic reticulum

endoplasmic reticulum lumen

 
229994_at NFIA nuclear factor I/A 1 61315533, 61320121, 61320567 R45950 1p31.3-p31.2 Hs.594180 Hs.710546 20

transcription factor activity

intracellular

nucleus

nucleus

cytoplasm

plasma membrane

DNA replication

regulation of transcription, DNA-dependent

transcription factor binding

viral genome replication

 
208205_at PCDHA9 protocadherin alpha 9 5 140207540, 140207540 NM_014005 5q31 Hs.199343 11

calcium ion binding

protein binding

plasma membrane

cell adhesion

homophilic cell adhesion

integral to membrane

 
212576_at MGRN1 mahogunin, ring finger 1 16 4614826 AB011116 16p13.3 Hs.526494 10

protein binding

zinc ion binding

ligase activity

modification-dependent protein catabolic process

metal ion binding

Ubiquitin mediated proteolysis

200614_at 0.305 9.672 2.686 1.678e-02 0.467 -2.994 CLTC clathrin, heavy chain (Hc) 17 55051831 NM_004859 17q11-qter Hs.491351 Hs.663896 77

structural molecule activity

protein binding

plasma membrane

intracellular protein transport

vesicle-mediated transport

clathrin coat of trans-Golgi network vesicle

clathrin coat of coated pit

cytoplasmic vesicle

melanosome

Lysosome

Endocytosis

Huntington's disease

210872_x_at 0.521 4.638 3.920 1.331e-03 0.245 -0.842 GAS7 growth arrest-specific 7 17 -9754650, -9754650, -9754650, -9754650 BC001152 17p13.1 Hs.462214 11

transcription factor activity

protein binding

cytoplasm

cell cycle arrest

multicellular organismal development

nervous system development

cell differentiation

 
212497_at MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 14 54588114 AI554879 14q22.3 Hs.594338 Hs.619374 8    
234647_at KCNIP3 Kv channel interacting protein 3, calsenilin 2 95326798, 95376494 AK026052 2q21.1 Hs.437376 43

negative regulation of transcription from RNA polymerase II promoter

DNA binding

transcription corepressor activity

voltage-gated ion channel activity

potassium channel activity

calcium ion binding

nucleus

cytoplasm

endoplasmic reticulum

Golgi apparatus

cytosol

plasma membrane

ion transport

potassium ion transport

apoptosis

signal transduction

behavior

protein C-terminus binding

specific transcriptional repressor activity

sensory perception of pain

potassium ion binding

regulation of neuron apoptosis

regulation of transcription

response to pain

calcium-dependent protein binding

 
217325_at KRT3 keratin 3 12 -51469735 X05421 12q12-q13 Hs.680652 9

structural molecule activity

structural molecule activity

epithelial cell differentiation

keratin filament

intermediate filament cytoskeleton organization

 
209555_s_at CD36 CD36 molecule (thrombospondin receptor) 7 80069439, 80105767, 80105767, 80113580, 80113697 M98399 7q11.2 Hs.120949 173

positive regulation of cell-matrix adhesion

low-density lipoprotein receptor activity

membrane fraction

Golgi apparatus

plasma membrane

integral to plasma membrane

lipid metabolic process

transport

cell adhesion

nitric oxide mediated signal transduction

blood coagulation

high-density lipoprotein binding

lipid binding

cell surface

cell surface

positive regulation of foam cell differentiation

plasma membrane long-chain fatty acid transport

lipid storage

cGMP-mediated signaling

cholesterol transport

platelet alpha granule membrane

lipoprotein particle clearance

lipoprotein catabolic process

lipoprotein transport

apoptotic cell clearance

transforming growth factor beta binding

thrombospondin receptor activity

PPAR signaling pathway

ECM-receptor interaction

Hematopoietic cell lineage

Adipocytokine signaling pathway

207303_at -0.204 3.652 -2.203 4.343e-02 0.578 -3.788 PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 7 -31795771 NM_005020 7p14.3 Hs.655694 10

calmodulin-dependent cyclic-nucleotide phosphodiesterase activity

calmodulin binding

signal transduction

hydrolase activity

Purine metabolism

Calcium signaling pathway

Olfactory transduction

201183_s_at CHD4 chromodomain helicase DNA binding protein 4 12 -6549508 AI613273 12p13 Hs.162233 32

nucleotide binding

chromatin

DNA binding

chromatin binding

ATP-dependent DNA helicase activity

helicase activity

ATP binding

nucleus

chromatin assembly or disassembly

regulation of transcription from RNA polymerase II promoter

transcription factor binding

zinc ion binding

chromatin modification

hydrolase activity

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

regulation of transcription

metal ion binding

 
212379_at GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 21 -33818186, -33798108, -33798108, -33798108 BE966876 21q22.1 21q22.11 Hs.473648 23

nucleotide binding

phosphoribosylamine-glycine ligase activity

phosphoribosylamine-glycine ligase activity

phosphoribosylformylglycinamidine cyclo-ligase activity

phosphoribosylformylglycinamidine cyclo-ligase activity

phosphoribosylglycinamide formyltransferase activity

protein binding

ATP binding

cytoplasm

cytosol

purine nucleotide biosynthetic process

'de novo' IMP biosynthetic process

methyltransferase activity

biosynthetic process

purine base biosynthetic process

transferase activity

ligase activity

manganese ion binding

metal ion binding

Purine metabolism

One carbon pool by folate

Metabolic pathways

1557283_a_at ZNF519 zinc finger protein 519 18 -14094723 BC037787 18p11.21 Hs.352635 4

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
206273_at SLMO1 slowmo homolog 1 (Drosophila) 18 12397894 NM_006553 18p11.21 Hs.514718 3    
222679_s_at DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 3 -184143252 AW468880 3q26.3 Hs.715661 16

molecular_function

cellular_component

biological_process

modification-dependent protein catabolic process

 
202873_at -0.190 4.301 -2.226 4.154e-02 0.572 -3.751 ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 8 104102423 BF034973 8q22.3 Hs.86905 19

transporter activity

protein binding

plasma membrane

ion transport

ATP synthesis coupled proton transport

proton transport

proton-transporting two-sector ATPase complex

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

proton-transporting V-type ATPase, V1 domain

proton-transporting ATPase activity, rotational mechanism

Oxidative phosphorylation

Metabolic pathways

Vibrio cholerae infection

Epithelial cell signaling in Helicobacter pylori infection

213726_x_at TUBB2C tubulin, beta 2C 9 139255531 AA515698 9q34 Hs.433615 25

nucleotide binding

GTPase activity

structural molecule activity

GTP binding

cytoskeleton

microtubule

cell motion

microtubule-based movement

natural killer cell mediated cytotoxicity

MHC class I protein binding

protein complex

unfolded protein binding

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

206375_s_at 0.683 9.876 2.891 1.108e-02 0.425 -2.643 HSPB3 heat shock 27kDa protein 3 5 53787201 NM_006308 5q11.2 Hs.41707 6

response to unfolded protein

response to heat

 
1566207_at TCEA1 transcription elongation factor A (SII), 1 8 -55041668 BQ286789 8q11.2 Hs.491745 32

DNA binding

transcription elongation regulator activity

translation elongation factor activity

protein binding

nucleus

nucleoplasm

nucleoplasm

RNA elongation

zinc ion binding

general RNA polymerase II transcription factor activity

erythrocyte differentiation

positive regulation of transcription from RNA polymerase II promoter

metal ion binding

 
234644_x_at TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 8 23016378 AK026079 8p22-p21 Hs.655801 43

transmembrane receptor activity

plasma membrane

integral to plasma membrane

apoptosis

signal transduction

anchored to membrane

Cytokine-cytokine receptor interaction

Apoptosis

Natural killer cell mediated cytotoxicity

209135_at ASPH aspartate beta-hydroxylase 8 -62739837, -62699648, -62699648, -62575669 AF289489 8q12.1 Hs.591874 24

peptide-aspartate beta-dioxygenase activity

binding

iron ion binding

calcium ion binding

endoplasmic reticulum

endoplasmic reticulum membrane

muscle contraction

pattern specification process

negative regulation of cell proliferation

structural constituent of muscle

electron carrier activity

membrane

integral to membrane

oxidoreductase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

peptidyl-amino acid modification

integral to endoplasmic reticulum membrane

limb morphogenesis

peptidyl-aspartic acid hydroxylation

oxidation reduction

palate development

face morphogenesis

 
222826_at PLDN pallidin homolog (mouse) 15 43666708 BC004819 15q21.1 Hs.719102 17

cellular_component

cytoplasm

endosome

membrane fusion

blood coagulation

membrane

synaptic vesicle docking during exocytosis

melanocyte differentiation

syntaxin-13 binding

positive regulation of natural killer cell activation

secretion of lysosomal enzymes

identical protein binding

pigmentation

 
233544_at GNL1 guanine nucleotide binding protein-like 1 6 -30621672, -1962248, -1760543 X66436 6p21.3 Hs.83147 5

nucleotide binding

T cell mediated immunity

structural molecule activity

GTP binding

extracellular space

intracellular

response to DNA damage stimulus

signal transduction

 
226123_at CHD7 chromodomain helicase DNA binding protein 7 8 61753892 AI870918 8q12.1-q12.2 Hs.20395 36

nucleotide binding

chromatin

skeletal system development

blood vessel development

in utero embryonic development

heart morphogenesis

DNA binding

chromatin binding

helicase activity

ATP binding

nucleus

chromatin assembly or disassembly

central nervous system development

adult heart development

sensory perception of sound

locomotory behavior

adult walking behavior

blood circulation

chromatin modification

hydrolase activity

cranial nerve development

T cell differentiation

female genitalia development

embryonic hindlimb morphogenesis

positive regulation of multicellular organism growth

inner ear morphogenesis

nose development

regulation of transcription

cognition

palate development

retina development in camera-type eye

regulation of growth hormone secretion

limb development

face development

 
212325_at LIMCH1 LIM and calponin homology domains 1 4 41057560, 41309675 AK027231 4p13 Hs.335163 10

actin binding

zinc ion binding

actomyosin structure organization

metal ion binding

 
212004_at C1orf144 chromosome 1 open reading frame 144 1 16566169 AL050028 1p36.13 Hs.252967 2    
216561_x_at SOX5 SRY (sex determining region Y)-box 5 12 -23576497, -23576497, -23576497 AF032454 12p12.1 Hs.657542 24

transcription factor activity

nucleus

transcription from RNA polymerase II promoter

regulation of transcription

 
214230_at 0.325 3.438 2.762 1.438e-02 0.447 -2.864 CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1 22251706, 22251706 R37664 1p36.1 Hs.690198 265

nucleotide binding

GTPase activity

protein binding

GTP binding

intracellular

cytoplasm

cytosol

plasma membrane

establishment or maintenance of cell polarity

small GTPase mediated signal transduction

actin cytoskeleton organization

filopodium

macrophage differentiation

positive regulation of pseudopodium assembly

negative regulation of protein complex assembly

MAPK signaling pathway

Chemokine signaling pathway

Endocytosis

Axon guidance

VEGF signaling pathway

Focal adhesion

Adherens junction

Tight junction

T cell receptor signaling pathway

Fc gamma R-mediated phagocytosis

Leukocyte transendothelial migration

Neurotrophin signaling pathway

Regulation of actin cytoskeleton

GnRH signaling pathway

Epithelial cell signaling in Helicobacter pylori infection

Pathogenic Escherichia coli infection - EHEC

Pathways in cancer

Renal cell carcinoma

Pancreatic cancer

212511_at PICALM phosphatidylinositol binding clathrin assembly protein 11 -85346132 AI766247 11q14 Hs.163893 22

phospholipid binding

phosphatidylinositol binding

Golgi apparatus

coated pit

protein complex assembly

receptor-mediated endocytosis

membrane

clathrin coat

clathrin-coated vesicle

clathrin binding

cytoplasmic vesicle

clathrin coat assembly

 
226469_s_at GGT7 gamma-glutamyltransferase 7 20 -32896183 AL049709 20q11.22 Hs.433738 9

gamma-glutamyltransferase activity

glutathione biosynthetic process

acyltransferase activity

membrane

integral to membrane

transferase activity

Taurine and hypotaurine metabolism

Selenoamino acid metabolism

Cyanoamino acid metabolism

Glutathione metabolism

Arachidonic acid metabolism

Metabolic pathways

228184_at DISP1 dispatched homolog 1 (Drosophila) 1 221168405 AK023679 1q41 Hs.528817 5

multicellular organismal development

hedgehog receptor activity

membrane

integral to membrane

 
1553634_a_at FLJ40852 hypothetical LOC285962 7 -141050606 NM_173677 7q34 Hs.17589 2    
220397_at MDM1 Mdm1 nuclear protein homolog (mouse) 12 -67005051, -66974612 NM_020128 12q15 Hs.655702 6

nucleus

 
225613_at MAST4 microtubule associated serine/threonine kinase family member 4 5 65927931, 66160359 AI096389 5q12.3 Hs.595458 5

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

protein amino acid phosphorylation

transferase activity

 
211714_x_at 0.616 9.583 2.313 3.508e-02 0.555 -3.612 TUBB tubulin, beta 6 30796135, 2136731, 1935034 BC005838 6p21.33 Hs.636480 Hs.706187 Hs.714425 39

nucleotide binding

GTPase activity

structural constituent of cytoskeleton

GTP binding

cytoskeleton

microtubule

cell motion

microtubule-based movement

flotillin complex

natural killer cell mediated cytotoxicity

MHC class I protein binding

spindle assembly

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

215366_at SNX13 sorting nexin 13 7 -17796910 AL353943 7p21.1 Hs.487648 10

signal transducer activity

protein binding

cell communication

negative regulation of signal transduction

protein transport

phosphoinositide binding

 
219623_at ACTR5 ARP5 actin-related protein 5 homolog (yeast) 20 36810510 NM_024855 20q11.23 Hs.371585 7

protein binding

ATP binding

regulation of transcription

 
207105_s_at PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 19 18125015 NM_005027 19q13.2-q13.4 Hs.371344 68

protein binding

intracellular

cytosol

phosphoinositide 3-kinase complex

signal transduction

1-phosphatidylinositol-3-kinase activity

negative regulation of anti-apoptosis

phosphoinositide 3-kinase regulator activity

ErbB signaling pathway

Chemokine signaling pathway

Phosphatidylinositol signaling system

mTOR signaling pathway

Apoptosis

VEGF signaling pathway

Focal adhesion

Toll-like receptor signaling pathway

Jak-STAT signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Fc gamma R-mediated phagocytosis

Leukocyte transendothelial migration

Neurotrophin signaling pathway

Regulation of actin cytoskeleton

Insulin signaling pathway

Type II diabetes mellitus

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Endometrial cancer

Glioma

Prostate cancer

Melanoma

Chronic myeloid leukemia

Acute myeloid leukemia

Small cell lung cancer

Non-small cell lung cancer

1553711_a_at -0.230 4.566 -2.309 3.536e-02 0.556 -3.618 C4orf39 chromosome 4 open reading frame 39 4 166097549 NM_153027 4q32.3 Hs.178648 Hs.710449 2    
1558212_at FLJ35024 hypothetical LOC401491 9 -2525654 BC004474 9p24.2 Hs.416043 2    
202136_at 0.299 9.463 3.036 8.237e-03 0.387 -2.391 ZMYND11 zinc finger, MYND domain containing 11 10 170423, 170423 BE250417 10p14 Hs.292265 17

negative regulation of transcription from RNA polymerase II promoter

DNA binding

protein binding

nucleus

cell cycle

zinc ion binding

cell proliferation

regulation of transcription

metal ion binding

 
203484_at SEC61G Sec61 gamma subunit 7 -54787433 NM_014302 7p11.2 Hs.488282 10

endoplasmic reticulum

protein targeting

P-P-bond-hydrolysis-driven protein transmembrane transporter activity

membrane

integral to membrane

intracellular protein transmembrane transport

Vibrio cholerae infection

215146_s_at TTC28 tetratricopeptide repeat domain 28 22 -26704003 AB028966 22q12.1 Hs.387856 Hs.719265 6

binding

 
218331_s_at C10orf18 chromosome 10 open reading frame 18 10 5766806 NM_017782 10p15.1 Hs.699500 4    
240618_at PTPRA protein tyrosine phosphatase, receptor type, A 20 2792840, 2802141, 2851852 BF439479 20p13 Hs.269577 58

transmembrane receptor protein tyrosine phosphatase activity

integral to plasma membrane

protein amino acid phosphorylation

protein amino acid dephosphorylation

membrane

hydrolase activity

 
211955_at IPO5 importin 5 13 97403929 NM_002271 13q32.2 Hs.712598 53

protein import into nucleus, docking

GTPase inhibitor activity

protein binding

nucleus

nuclear pore

nucleolus

cytoplasm

NLS-bearing substrate import into nucleus

intracellular protein transport

Ran GTPase binding

protein transporter activity

interspecies interaction between organisms

 
219547_at COX15 COX15 homolog, cytochrome c oxidase assembly protein (yeast) 10 -101458494 NM_004376 10q24 Hs.28326 9

catalytic activity

cytochrome-c oxidase activity

mitochondrial respiratory chain

mitochondrial electron transport, cytochrome c to oxygen

protein complex assembly

heme a biosynthetic process

respiratory gaseous exchange

respiratory chain complex IV assembly

membrane

integral to membrane

mitochondrial part

cellular respiration

oxidation reduction

Oxidative phosphorylation

Porphyrin and chlorophyll metabolism

Metabolic pathways

218423_x_at VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2 -63973170 NM_016516 2p13-p14 Hs.48499 8

protein binding

protein transport

retrograde transport, endosome to Golgi

 
1553023_a_at NOX5 NADPH oxidase, EF-hand calcium binding domain 5 15 67009917 NM_024505 15q23 Hs.657932 27

cytokinesis

ion channel activity

calcium ion binding

ion transport

induction of apoptosis

cell proliferation

electron carrier activity

regulation of proton transport

hydrogen ion channel activity

hydrogen ion channel activity

membrane

integral to membrane

superoxide-generating NADPH oxidase activity

superoxide-generating NADPH oxidase activity

oxidoreductase activity

heme binding

electron transport chain

superoxide anion generation

superoxide anion generation

regulation of fusion of sperm to egg plasma membrane

FAD binding

NADP or NADPH binding

cytokine secretion

 
220975_s_at C1QTNF1 C1q and tumor necrosis factor related protein 1 17 74531845, 74542066 NM_030968 17q25.3 Hs.201398 11

extracellular region

 
241533_at LOC731656 hypothetical LOC731656 1   AV652367   Hs.702477 1    
225308_s_at 0.383 6.133 2.472 2.568e-02 0.517 -3.352 TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 2 159533391 AB051515 2q24.2 Hs.61590 6

binding

plasma membrane

postsynaptic density

cell junction

synapse

postsynaptic membrane

 
213014_at MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 11 45863777 BG222394 11p12-p11.2 Hs.234249 46

protein kinase inhibitor activity

MAP-kinase scaffold activity

protein binding

nucleus

cytoplasm

vesicle-mediated transport

kinesin binding

protein kinase binding

regulation of JNK cascade

perinuclear region of cytoplasm

MAPK signaling pathway

244296_at hCG_1776047 hCG1776047 18   T78442 18q21.2   1    
211332_x_at HFE hemochromatosis 6 26195487 AF144241 6p21.3 Hs.233325 592

antigen processing and presentation of peptide antigen via MHC class I

iron ion binding

protein binding

cytoplasm

early endosome

plasma membrane

integral to plasma membrane

protein complex assembly

ion transport

iron ion transport

cellular iron ion homeostasis

receptor-mediated endocytosis

immune response

antigen processing and presentation

cytoplasmic vesicle

MHC class I protein complex

apical part of cell

basal part of cell

perinuclear region of cytoplasm

recycling endosome

 
1567241_at OR2L1P olfactory receptor, family 2, subfamily L, member 1 pseudogene 1 246220191 X64980 1q44 Hs.684887 1    
1557953_at 0.279 6.391 2.260 3.892e-02 0.567 -3.698 ZKSCAN1 zinc finger with KRAB and SCAN domains 1 7 99451154 BG761185 7q21.3-q22.1 Hs.615360 11

transcription factor activity

intracellular

nucleus

cytoplasm

mitochondrion

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
203648_at TATDN2 TatD DNase domain containing 2 3 10265176 NM_014760 3p25.3 Hs.475401 Hs.611748 5

nuclease activity

nucleus

hydrolase activity

endodeoxyribonuclease activity, producing 5'-phosphomonoesters

 
206694_at PNLIPRP1 pancreatic lipase-related protein 1 10 118340479 NM_006229 10q25.3 Hs.73923 3

triacylglycerol lipase activity

extracellular region

lipid catabolic process

hydrolase activity

Glycerolipid metabolism

Metabolic pathways

223633_s_at BCAN brevican 1 154878363, 154878363 BC005081 1q31 Hs.516904 Hs.663621 17

binding

sugar binding

hyaluronic acid binding

extracellular region

proteinaceous extracellular matrix

cell adhesion

membrane

anchored to membrane

 
201024_x_at EIF5B eukaryotic translation initiation factor 5B 2 99320265 BG261322 2q11.2 Hs.158688 15

nucleotide binding

translation initiation factor activity

translation initiation factor activity

GTPase activity

protein binding

GTP binding

cytoplasm

translation

regulation of translational initiation

regulation of translational initiation

 
208661_s_at TTC3 tetratricopeptide repeat domain 3 21 37367440, 37377116 AW510696 21q22.2 Hs.368214 9

protein binding

cellular_component

vacuole

biological_process

zinc ion binding

negative regulation of cell morphogenesis involved in differentiation

negative regulation of neuron differentiation

metal ion binding

response to protein stimulus

 
1552365_at -0.399 2.789 -2.603 1.981e-02 0.491 -3.134 SCIN scinderin 7 12576727, 12595672 NM_033128 7p21.3 Hs.633359 Hs.655515 14

phosphatidylserine binding

calcium ion binding

calcium ion binding

phosphatidylinositol binding

phosphatidylinositol-4,5-bisphosphate binding

cytoplasm

cytoskeleton

cell cortex

negative regulation of cell proliferation

calcium ion-dependent exocytosis

positive regulation of apoptosis

actin nucleation

positive regulation of megakaryocyte differentiation

actin filament severing

actin filament binding

positive regulation of secretion

actin filament capping

Fc gamma R-mediated phagocytosis

Regulation of actin cytoskeleton

205107_s_at EFNA4 ephrin-A4 1 153302836 NM_005227 1q21-q22 Hs.449913 Hs.639422 23

transmembrane-ephrin receptor activity

extracellular region

plasma membrane

integral to plasma membrane

cell-cell signaling

anchored to membrane

Axon guidance

212841_s_at PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 11 7491576 AI692180 11p15.4 Hs.655714 8

molecular_function

DNA binding

intracellular

cell communication

integrase activity

DNA integration

 
208630_at HADHA hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit 2 -26267007 AI972144 2p23 Hs.516032 36

acyl-CoA binding

3-hydroxyacyl-CoA dehydrogenase activity

acetyl-CoA C-acetyltransferase activity

acetyl-CoA C-acyltransferase activity

enoyl-CoA hydratase activity

binding

mitochondrion

mitochondrial inner membrane

lipid metabolic process

fatty acid metabolic process

fatty acid beta-oxidation

oxidoreductase activity

fatty acid beta-oxidation multienzyme complex

long-chain-enoyl-CoA hydratase activity

long-chain-3-hydroxyacyl-CoA dehydrogenase activity

lyase activity

response to drug

mitochondrial nucleoid

NAD or NADH binding

oxidation reduction

Fatty acid elongation in mitochondria

Fatty acid metabolism

Valine, leucine and isoleucine degradation

Lysine degradation

Tryptophan metabolism

beta-Alanine metabolism

Benzoate degradation via CoA ligation

Propanoate metabolism

Butanoate metabolism

Limonene and pinene degradation

Caprolactam degradation

Biosynthesis of unsaturated fatty acids

Metabolic pathways

213511_s_at MTMR1 myotubularin related protein 1 X 149612526 AI167164 Xq28 Hs.347187 10

protein tyrosine phosphatase activity

cellular_component

plasma membrane

dephosphorylation

hydrolase activity

phosphatase activity

Fructose and mannose metabolism

Thiamine metabolism

Riboflavin metabolism

Metabolic pathways

200640_at 0.476 7.791 3.413 3.785e-03 0.318 -1.730 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 8 -101999980, -101999980, -101999980, -101999980, -101999980 NM_003406 8q23.1 Hs.492407 Hs.594673 169

nucleus

cytoplasm

mitochondrion

protein targeting

anti-apoptosis

signal transduction

transcription factor binding

protein domain specific binding

melanosome

Cell cycle

Neurotrophin signaling pathway

Pathogenic Escherichia coli infection - EHEC

1560472_at -0.322 5.328 -3.190 6.005e-03 0.358 -2.123 LOC338588 hypothetical LOC338588 10 4688347 BC040895 10p15.1 Hs.121365 1    
203144_s_at 0.278 4.581 2.194 4.417e-02 0.579 -3.802 KIAA0040 KIAA0040 1 -173392745, -173392745 NM_014656 1q24-q25 Hs.518138 6    
1569003_at TMEM49 transmembrane protein 49 17 55139644 AL541655 17q23.1 Hs.444569 Hs.708260 13

endoplasmic reticulum

membrane

integral to membrane

 
230956_at C11orf92 chromosome 11 open reading frame 92 11 -110669379 AI347581 11q23.1 Hs.125166 1

membrane

integral to membrane

 
235160_at ATF7 activating transcription factor 7 12 -52192109, -52192109 BG105181 12q13 Hs.12286 18

transcription factor activity

intracellular

nucleus

cytoplasm

regulation of transcription, DNA-dependent

zinc ion binding

sequence-specific DNA binding

metal ion binding

protein dimerization activity

 
225733_at 0.252 5.786 2.496 2.449e-02 0.513 -3.312 B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 1 1157491 AI890557 1p36.33 Hs.284284 4

Golgi apparatus

Golgi medial cisterna

glycosaminoglycan biosynthetic process

protein amino acid glycosylation

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

membrane

integral to membrane

transferase activity, transferring glycosyl groups

manganese ion binding

galactosylxylosylprotein 3-beta-galactosyltransferase activity

Chondroitin sulfate biosynthesis

Heparan sulfate biosynthesis

Metabolic pathways

215016_x_at DST dystonin 6 -56587338, -56576527, -56430743, -56430743, -56430743, -56430743, -56430743 BC004912 6p12.1 Hs.631992 Hs.669931 48

actin binding

integrin binding

calcium ion binding

protein binding

protein binding

basement membrane

cytoplasm

cytoplasm

cytoskeleton

cell cycle arrest

cell adhesion

integrin-mediated signaling pathway

protein C-terminus binding

cytoplasmic membrane-bounded vesicle

actin cytoskeleton organization

hemidesmosome

intermediate filament cytoskeleton organization

intermediate filament cytoskeleton organization

intermediate filament cytoskeleton organization

actin filament binding

 
224376_s_at C20orf24 chromosome 20 open reading frame 24 20 34667580, 34667605 AF274948 20q11.23 Hs.584985 7

molecular_function

protein binding

cellular_component

biological_process

 
208242_at RAX retina and anterior neural fold homeobox 18 -55085246 NM_013435 18q21.32 Hs.278957 8

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

visual perception

sequence-specific DNA binding

 
231734_at RBP2 retinol binding protein 2, cellular 3 -140654415 NM_004164 3q23 Hs.655516 14

transporter activity

cytoplasm

vitamin A metabolic process

transport

lipid binding

epidermis development

retinal binding

retinol binding

 
241580_at ZNF518B zinc finger protein 518B 4 -10050601 AI375526 4p16.1 Hs.455089 3

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
226287_at CCDC34 coiled-coil domain containing 34 11 -27326994, -27316636 AI458313 11p14.1 Hs.143733 4    
217957_at C16orf80 chromosome 16 open reading frame 80 16 -56704997 NM_013242 16q21 Hs.532755 3

multicellular organismal development

 
210006_at ABHD14A abhydrolase domain containing 14A 3 51984081 BC002571 3p21.1 Hs.534400 6

cytoplasm

membrane

integral to membrane

hydrolase activity

 
224747_at UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 15 73922676, 73923439 AK000617 15q24.2 Hs.23033 4

nucleotide binding

ubiquitin-protein ligase activity

ATP binding

cytoplasm

ligase activity

modification-dependent protein catabolic process

post-translational protein modification

regulation of protein metabolic process

Ubiquitin mediated proteolysis

210072_at -0.254 3.942 -2.712 1.592e-02 0.459 -2.950 CCL19 chemokine (C-C motif) ligand 19 9 -34679566 U88321 9p13 Hs.50002 39

extracellular region

extracellular space

cellular calcium ion homeostasis

chemotaxis

inflammatory response

immune response

signal transduction

chemokine activity

response to virus

Cytokine-cytokine receptor interaction

Chemokine signaling pathway

205442_at MFAP3L microfibrillar-associated protein 3-like 4 -171144322, -171144322 NM_021647 4q32.3 Hs.593942 3

plasma membrane

integral to membrane

 
202495_at TBCC tubulin folding cofactor C 6 -42820211 NM_003192 6pter-p12.1 Hs.75064 6

binding

cytoskeleton

microtubule

post-chaperonin tubulin folding pathway

chaperone binding

 
212327_at LIMCH1 LIM and calponin homology domains 1 4 41057560, 41309675 AK026815 4p13 Hs.335163 10

actin binding

zinc ion binding

actomyosin structure organization

metal ion binding

 
205319_at PSCA prostate stem cell antigen 8 143758876 NM_005672 8q24.2 Hs.652235 Hs.711174 31

plasma membrane

anchored to membrane

 
208173_at IFNB1 interferon, beta 1, fibroblast 9 -21067103 NM_002176 9p21 Hs.93177 127

transcription corepressor activity

cytokine activity

interferon-alpha/beta receptor binding

extracellular region

extracellular space

induction of apoptosis

activation of caspase activity

activation of caspase activity

cell surface receptor linked signal transduction

negative regulation of cell proliferation

response to virus

natural killer cell activation

negative regulation of viral transcription

B cell proliferation

defense response to bacterium

positive regulation of innate immune response

regulation of MHC class I biosynthetic process

negative regulation of virion penetration into host cell

Cytokine-cytokine receptor interaction

Toll-like receptor signaling pathway

RIG-I-like receptor signaling pathway

Jak-STAT signaling pathway

Natural killer cell mediated cytotoxicity

1555748_x_at CD79B CD79b molecule, immunoglobulin-associated beta 17 -59359829 BC030210 17q23 Hs.89575 45

transmembrane receptor activity

nucleus

cytoplasm

Golgi apparatus

plasma membrane

integral to plasma membrane

immune response

cell surface receptor linked signal transduction

B cell receptor signaling pathway

201797_s_at VARS valyl-tRNA synthetase 6 -31853275, -3191374, -3006978 NM_006295 6p21.3 Hs.520026 15

nucleotide binding

valine-tRNA ligase activity

protein binding

ATP binding

intracellular

cytoplasm

mitochondrion

cytosol

translational elongation

valyl-tRNA aminoacylation

defense response

response to unfolded protein

response to nutrient

ligase activity

protein complex

NF-kappaB binding

Valine, leucine and isoleucine biosynthesis

Aminoacyl-tRNA biosynthesis

202393_s_at -0.663 9.258 -2.370 3.139e-02 0.543 -3.519 KLF10 Kruppel-like factor 10 8 -103730182, -103730182 NM_005655 8q22.2 Hs.435001 26

negative regulation of transcription from RNA polymerase II promoter

skeletal system development

transcription factor activity

protein binding

intracellular

nucleus

transforming growth factor beta receptor signaling pathway

cell-cell signaling

zinc ion binding

negative regulation of cell proliferation

regulation of transcription

metal ion binding

 
1554057_at LOC645676 hypothetical LOC645676 1 153798395 BC017347 1q22 Hs.491060 Hs.568693 1    
205650_s_at FGA fibrinogen alpha chain 4 -155725878, -155723729 NM_021871 4q28 Hs.351593 180

receptor binding

extracellular region

extracellular region

fibrinogen complex

plasma membrane

signal transduction

external side of plasma membrane

platelet activation

protein binding, bridging

platelet alpha granule lumen

tissue regeneration

eukaryotic cell surface binding

protein polymerization

response to calcium ion

Complement and coagulation cascades

241759_at MGC5566 hypothetical protein MGC5566 20   T82487 20q13.12 Hs.255479 1    
204831_at CDK8 cyclin-dependent kinase 8 13 25726755 R59697 13q12 Hs.382306 38

nucleotide binding

cyclin-dependent protein kinase activity

protein binding

ATP binding

nucleus

protein amino acid phosphorylation

RNA polymerase II carboxy-terminal domain kinase activity

transferase activity

regulation of transcription

 
208198_x_at KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 19 257787 NM_014512 19q13.4 Hs.512572 57

transmembrane receptor activity

plasma membrane

immune response

integral to membrane

Antigen processing and presentation

Natural killer cell mediated cytotoxicity

222539_at CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 15 -66286385 NM_017882 15q23 Hs.584921 21

ganglioside metabolic process

endoplasmic reticulum

endoplasmic reticulum lumen

lysosomal lumen acidification

visual perception

cholesterol metabolic process

membrane

integral to membrane

protein catabolic process

glycosaminoglycan metabolic process

locomotion involved in locomotory behavior

protein homodimerization activity

cellular macromolecule catabolic process

positive regulation of proteolysis

 
221015_s_at CDADC1 cytidine and dCMP deaminase domain containing 1 13 48720103 NM_030911 13q14.2 Hs.388220 2

zinc ion binding

hydrolase activity

metal ion binding

 
211663_x_at PTGDS prostaglandin D2 synthase 21kDa (brain) 9 138991776 M61900 9q34.2-q34.3 Hs.446429 63

prostaglandin biosynthetic process

prostaglandin-D synthase activity

transporter activity

binding

retinoid binding

extracellular region

nucleus

cytoplasm

rough endoplasmic reticulum

Golgi apparatus

fatty acid biosynthetic process

transport

membrane

isomerase activity

nuclear membrane

regulation of circadian sleep/wake cycle, sleep

perinuclear region of cytoplasm

Arachidonic acid metabolism

Metabolic pathways

232370_at -0.240 5.759 -2.156 4.745e-02 0.585 -3.861 LOC254057 hypothetical protein LOC254057 3   AI635756 3q21.3 Hs.586109      
229530_at GUCY1A3 guanylate cyclase 1, soluble, alpha 3 4 156807311, 156807311, 156807311, 156807598, 156807598, 156808264 BF002625 4q31.1-q31.2 4q31.3-q33 Hs.24258 14

nucleotide binding

guanylate cyclase activity

receptor activity

GTP binding

cytoplasm

nitric oxide mediated signal transduction

guanylate cyclase complex, soluble

regulation of blood pressure

positive regulation of cGMP biosynthetic process

response to defense-related host nitric oxide production

relaxation of vascular smooth muscle

Purine metabolism

Vascular smooth muscle contraction

Gap junction

Long-term depression

231887_s_at KIAA1274 KIAA1274 10 71908569 AB033100 10q22.1 Hs.202351 5    
213274_s_at CTSB cathepsin B 8 -11737442 AA020826 8p22 Hs.520898 140

cysteine-type endopeptidase activity

extracellular region

intracellular

soluble fraction

mitochondrion

lysosome

proteolysis

peptidase activity

response to wounding

external side of plasma membrane

apical plasma membrane

kininogen binding

peptide binding

melanosome

regulation of apoptosis

regulation of catalytic activity

Lysosome

Antigen processing and presentation

233030_at 0.635 4.430 2.269 3.826e-02 0.565 -3.684 PNPLA3 patatin-like phospholipase domain containing 3 22 42650951 AK025665 22q13.31 Hs.654800 20

phospholipase A2 activity

triacylglycerol lipase activity

metabolic process

acyltransferase activity

membrane

integral to membrane

lipid catabolic process

transferase activity

hydrolase activity

triglyceride biosynthetic process

triglyceride catabolic process

mono-olein transacylation activity

diolein transacylation activity

Tyrosine metabolism

Phenylalanine metabolism

Glycerolipid metabolism

Glycerophospholipid metabolism

1- and 2-Methylnaphthalene degradation

Benzoate degradation via CoA ligation

Limonene and pinene degradation

Metabolic pathways

223048_at 0.305 7.411 2.576 2.092e-02 0.497 -3.180 SDHAF2 succinate dehydrogenase complex assembly factor 2 11 60954172 BC002331 11q12.2 Hs.313247 3

molecular_function

cellular_component

mitochondrion

biological_process

 
237300_at PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 14 57781345 AI553756 14q23 Hs.558799 58

threonine-type endopeptidase activity

protein binding

nucleus

cytoplasm

cytosol

proteasome core complex

cytoskeleton

ubiquitin-dependent protein catabolic process

peptidase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

proteolysis involved in cellular protein catabolic process

Proteasome

1561571_at -0.254 5.427 -2.946 9.886e-03 0.412 -2.546 LOC730139 hypothetical protein LOC730139 3   BC028116 3q27.3 Hs.679195 1    
230863_at LRP2 low density lipoprotein-related protein 2 2 -169691864 R73030 2q24-q31 Hs.657729 65

receptor activity

calcium ion binding

protein binding

membrane fraction

lysosome

endosome

endoplasmic reticulum

Golgi apparatus

brush border

coated pit

protein amino acid glycosylation

lipid metabolic process

vitamin metabolic process

receptor-mediated endocytosis

cell proliferation

membrane

integral to membrane

apical plasma membrane

SH3 domain binding

endocytic vesicle

forebrain development

Hedgehog signaling pathway

38269_at PRKD2 protein kinase D2 19 -51869412, -51869412 AL050147 19q13.3 Hs.466987 25

nucleotide binding

protein kinase C activity

ATP binding

intracellular

protein amino acid phosphorylation

intracellular signaling cascade

zinc ion binding

transferase activity

diacylglycerol binding

metal ion binding

 
218041_x_at 0.640 9.513 2.147 4.833e-02 0.589 -3.876 SLC38A2 solute carrier family 38, member 2 12 -45038238 NM_018573 12q Hs.221847 20

plasma membrane

ion transport

sodium ion transport

amino acid transport

symporter activity

integral to membrane

sodium ion binding

 
215883_at CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 5 138117005 AK022326 5q31 Hs.534797 Hs.656653 70

structural molecule activity

protein binding

cytoplasm

plasma membrane

adherens junction

cell adhesion

actin cytoskeleton

vinculin binding

cell junction

apical junction assembly

cadherin binding

Adherens junction

Tight junction

Leukocyte transendothelial migration

Pathways in cancer

Endometrial cancer

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

208423_s_at -0.244 3.095 -2.482 2.520e-02 0.514 -3.336 MSR1 macrophage scavenger receptor 1 8 -16041196, -16009757 NM_002445 8p22 Hs.147635 51

receptor activity

scavenger receptor activity

protein binding

integral to plasma membrane

receptor-mediated endocytosis

positive regulation of foam cell differentiation

positive regulation of cholesterol storage

membrane

low-density lipoprotein binding

cholesterol transport

low-density lipoprotein particle

lipoprotein particle clearance

 
202819_s_at TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) 1 23942442 NM_003198 1p36.1 Hs.15535 26

DNA binding

protein binding

nucleus

nucleoplasm

cytoplasm

regulation of transcription from RNA polymerase II promoter

integral to membrane

transcription regulator activity

regulation of transcription

 
204620_s_at 0.810 5.836 3.703 2.082e-03 0.275 -1.221 VCAN versican 5 82803248 NM_004385 5q14.3 Hs.643801 Hs.715773 74

binding

calcium ion binding

sugar binding

hyaluronic acid binding

extracellular region

proteinaceous extracellular matrix

cell adhesion

multicellular organismal development

cell recognition

Cell adhesion molecules (CAMs)

227111_at -0.483 5.341 -3.872 1.471e-03 0.250 -0.926 ZBTB34 zinc finger and BTB domain containing 34 9 128662764 BG179317 9q33.3 Hs.177633 4

DNA binding

protein binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
204697_s_at CHGA chromogranin A (parathyroid secretory protein 1) 14 92459197 NM_001275 14q32 Hs.150793 96

calcium ion binding

extracellular region

regulation of blood pressure

 
212958_x_at 0.462 9.545 2.621 1.910e-02 0.489 -3.103 PAM peptidylglycine alpha-amidating monooxygenase 5 102229425 AI022882 5q14-q21 Hs.369430 34

monooxygenase activity

peptidylglycine monooxygenase activity

peptidylamidoglycolate lyase activity

copper ion binding

protein binding

extracellular region

protein modification process

peptide metabolic process

zinc ion binding

cellular process

membrane

integral to membrane

lyase activity

secretory granule

L-ascorbic acid binding

metal ion binding

oxidation reduction

 
215420_at -0.254 5.463 -2.344 3.308e-02 0.551 -3.563 IHH Indian hedgehog homolog (Drosophila) 2 -219627389 BE869172 2q33-q35 Hs.654504 41

skeletal system development

patterning of blood vessels

osteoblast differentiation

patched binding

protein binding

extracellular region

extracellular space

plasma membrane

proteolysis

cell-cell signaling

pattern specification process

peptidase activity

negative regulation of signal transduction

cholesterol binding

intein-mediated protein splicing

positive regulation of chondrocyte differentiation

negative regulation of apoptosis

negative regulation of cell differentiation

positive regulation of transcription from RNA polymerase II promoter

cell maturation

positive regulation of epithelial cell proliferation

Hedgehog signaling pathway

226318_at TBRG1 transforming growth factor beta regulator 1 11 123997951 AI701055 11q24.2 Hs.436410 11

DNA binding

protein binding

nucleus

DNA replication

cell cycle

cell cycle arrest

negative regulation of cell proliferation

nucleolus to nucleoplasm transport

protein stabilization

 
212251_at MTDH metadherin 8 98725582 AI972475 8q22.1 Hs.377155 23

negative regulation of transcription from RNA polymerase II promoter

protein binding

nucleus

nucleolus

cytoplasm

endoplasmic reticulum

tight junction

membrane

integral to membrane

cell junction

nuclear membrane

perinuclear region of cytoplasm

NF-kappaB binding

positive regulation of NF-kappaB transcription factor activity

 
201315_x_at IFITM2 interferon induced transmembrane protein 2 (1-8D) 11 298106 NM_006435 11p15.5 Hs.709321 6

protein binding

immune response

response to biotic stimulus

membrane

integral to membrane

 
201672_s_at USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 18 148482 NM_005151 18p11.32 Hs.464416 Hs.707058 15

cysteine-type endopeptidase activity

ubiquitin thiolesterase activity

ubiquitin-specific protease activity

cytoplasm

ubiquitin-dependent protein catabolic process

tRNA guanylyltransferase activity

peptidase activity

 
206207_at CLC Charcot-Leyden crystal protein 19 -44913734 NM_001828 19q13.1 Hs.889 25

lysophospholipase activity

sugar binding

multicellular organismal development

lipid catabolic process

hydrolase activity

 
238014_at TMEM194B transmembrane protein 194B 2 -191079864 AW291339 2q32.2 Hs.659824 2

membrane

integral to membrane

 
209089_at 0.293 9.034 2.669 1.737e-02 0.471 -3.023 RAB5A RAB5A, member RAS oncogene family 3 19963575 BC001267 3p24-p22 Hs.475663 73

nucleotide binding

ruffle

GTPase activity

protein binding

protein binding

GTP binding

early endosome

plasma membrane

endocytosis

small GTPase mediated signal transduction

protein transport

guanyl nucleotide binding

endocytic vesicle

melanosome

membrane raft

Endocytosis

Amyotrophic lateral sclerosis (ALS)

230323_s_at TMEM45B transmembrane protein 45B 11 129190950 AW242836 11q24.3 Hs.504301 3

membrane

integral to membrane

 
218456_at CAPRIN2 caprin family member 2 12 -30753752 NM_023925 12p11 Hs.234355 7

cytoplasm

mitochondrion

negative regulation of cell growth

regulation of growth

 
217365_at -0.271 4.164 -2.828 1.259e-02 0.429 -2.752 PRAMEF11 PRAME family member 11 1 -12807054 AL022101 1p36.21 Hs.551617 2    
218565_at 0.405 4.995 3.306 4.728e-03 0.337 -1.919 C9orf114 chromosome 9 open reading frame 114 9 -130624165 BG223334 9q34.11 Hs.224137 5

molecular_function

cellular_component

biological_process

 
223460_at CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha 17 -3715199, -3710365, -3710365 AL136576 17p13.2 Hs.8417 16

nucleotide binding

calmodulin-dependent protein kinase activity

calmodulin binding

ATP binding

nucleus

cytoplasm

protein amino acid phosphorylation

transferase activity

Adipocytokine signaling pathway

213749_at MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 3 -188447299, -188434565, -188418631 AV686235 3q27-q28 Hs.89983 30

complement activation, lectin pathway

complement activation, lectin pathway

serine-type endopeptidase activity

calcium ion binding

extracellular region

extracellular region

extracellular space

proteolysis

peptidase activity

protein homodimerization activity

calcium-dependent protein binding

Complement and coagulation cascades

215368_at NEB nebulin 2 -152050098 R78299 2q22 Hs.588655 32

actin binding

protein binding

cytoplasm

somatic muscle development

structural constituent of muscle

actin cytoskeleton

sarcomere

Z disc

regulation of actin filament length

 
216342_x_at -0.272 11.005 -2.169 4.635e-02 0.582 -3.842 RPS4X ribosomal protein S4, X-linked X -71409177 AL121916 Xq13.1 Hs.118076 25

structural constituent of ribosome

intracellular

cytosol

ribosome

polysome

translational elongation

multicellular organismal development

positive regulation of cell proliferation

rRNA binding

cytosolic small ribosomal subunit

cytosolic small ribosomal subunit

positive regulation of translation

Ribosome

231045_x_at C11orf31 chromosome 11 open reading frame 31 11 57265297 H29876 11q12.1 Hs.655373 Hs.719147 6

selenium binding

cell redox homeostasis

 
205813_s_at -0.262 5.284 -2.440 2.736e-02 0.526 -3.405 MAT1A methionine adenosyltransferase I, alpha 10 -82021555 NM_000429 10q22 Hs.282670 21

nucleotide binding

magnesium ion binding

methionine adenosyltransferase activity

ATP binding

cellular amino acid metabolic process

one-carbon metabolic process

transferase activity

potassium ion binding

cobalt ion binding

Cysteine and methionine metabolism

Selenoamino acid metabolism

Biosynthesis of plant hormones

Metabolic pathways

226924_at LOC400657 hypothetical LOC400657 18 -70409991 AI016355 18q22.3 Hs.61508 3    
211203_s_at CNTN1 contactin 1 12 39372624 U07820 12q11-q12 Hs.143434 30

protein binding

membrane fraction

plasma membrane

cell adhesion

Notch signaling pathway

anchored to membrane

Cell adhesion molecules (CAMs)

219157_at KLHL2 kelch-like 2, Mayven (Drosophila) 4 166348219, 166350620 NM_007246 4q21.2 Hs.388668 7

actin binding

transporter activity

protein binding

cytoplasm

intracellular protein transport

actin cytoskeleton

 
239629_at CFLAR CASP8 and FADD-like apoptosis regulator 2 201689060, 201689134, 201691631 AI634046 2q33-q34 Hs.390736 163

cysteine-type endopeptidase activity

protein binding

proteolysis

anti-apoptosis

induction of apoptosis by extracellular signals

regulation of apoptosis

positive regulation of I-kappaB kinase/NF-kappaB cascade

interspecies interaction between organisms

Apoptosis

1569246_a_at -0.366 5.127 -3.083 7.474e-03 0.376 -2.309 C8orf74 chromosome 8 open reading frame 74 8 10567556 BC038534 8p23.1 Hs.371776 2    
60084_at 0.307 3.429 2.412 2.895e-02 0.534 -3.452 CYLD cylindromatosis (turban tumor syndrome) 16 49333461, 49333529 AI453099 16q12.1 Hs.578973 54

structural constituent of ribosome

ubiquitin thiolesterase activity

intracellular

cytoplasm

ribosome

cytoskeleton

translation

ubiquitin-dependent protein catabolic process

cell cycle

peptidase activity

cysteine-type peptidase activity

perinuclear region of cytoplasm

RIG-I-like receptor signaling pathway

224498_x_at AXIN2 axin 2 17 -60955146 BC006295 17q23-q24 Hs.156527 38

somitogenesis

intramembranous ossification

signal transducer activity

protein binding

intracellular

nucleus

cytoplasm

signal transduction

multicellular organismal development

negative regulation of cell proliferation

regulation of Wnt receptor signaling pathway

negative regulation of osteoblast differentiation

Wnt signaling pathway

Pathways in cancer

Colorectal cancer

Endometrial cancer

Basal cell carcinoma

203213_at 0.489 3.318 2.559 2.162e-02 0.497 -3.207 CDC2 cell division cycle 2, G1 to S and G2 to M 10 62208225, 62208296, 62209904 AL524035 10q21.1 Hs.334562 350

nucleotide binding

cyclin-dependent protein kinase activity

cyclin-dependent protein kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

cytosol

spindle microtubule

protein amino acid phosphorylation

anti-apoptosis

cell cycle

mitosis

RNA polymerase II carboxy-terminal domain kinase activity

transferase activity

midbody

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

cell division

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Cell cycle

p53 signaling pathway

Gap junction

1564251_at -0.257 5.359 -2.326 3.423e-02 0.553 -3.591 EMID1 EMI domain containing 1 22 27931952 AL831910 22q12.2 Hs.289106 5

protein binding

extracellular region

proteinaceous extracellular matrix

endoplasmic reticulum

Golgi apparatus

 
206611_at -0.304 6.200 -2.428 2.802e-02 0.529 -3.425 C2orf27A chromosome 2 open reading frame 27A 2 132196533 NM_013310 2q21.1-q21.2 Hs.635289 Hs.655680 5    
227536_at -0.399 7.368 -2.787 1.367e-02 0.440 -2.821 ZC3H13 zinc finger CCCH-type containing 13 13 -45434314 AI472196 13q14.13 Hs.136102 11

nucleic acid binding

zinc ion binding

metal ion binding

 
239027_at DOCK8 dedicator of cytokinesis 8 9 204864 AV760561 9p24.3 Hs.132599 11

guanyl-nucleotide exchange factor activity

GTP binding

GTPase binding

 
212714_at LARP4 La ribonucleoprotein domain family, member 4 12 49080916 AL050205 12q13.12 Hs.26613 7

RNA binding

 
202351_at ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 2 187163034, 187173176 AI093579 2q31-q32 Hs.436873 240

blood vessel development

receptor activity

calcium ion binding

protein binding

plasma membrane

cell adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

integrin complex

external side of plasma membrane

negative regulation of foam cell differentiation

negative regulation of lipid storage

negative regulation of lipid transport

apoptotic cell clearance

interspecies interaction between organisms

negative regulation of low-density lipoprotein receptor biosynthetic process

negative regulation of lipoprotein metabolic process

Focal adhesion

ECM-receptor interaction

Cell adhesion molecules (CAMs)

Regulation of actin cytoskeleton

Pathways in cancer

Small cell lung cancer

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

223041_at CD99L2 CD99 molecule-like 2 X -149685466 AL136580 Xq28 Hs.522805 8

protein binding

plasma membrane

cell adhesion

integral to membrane

cell junction

 
213049_at GARNL1 GTPase activating Rap/RanGAP domain-like 1 14 -35077308 BG436400 14q13.2 Hs.113150 10

GTPase activator activity

intracellular

nucleus

cytoplasm

mitochondrion

regulation of small GTPase mediated signal transduction

 
204937_s_at 0.458 6.340 2.299 3.607e-02 0.558 -3.635 ZNF274 zinc finger protein 274 19 63386207 NM_016325 19qter Hs.658497 Hs.83761 11

transcription factor activity

transcription corepressor activity

protein binding

intracellular

nucleus

nucleolus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

Neurotrophin signaling pathway

225481_at FRMD6 FERM domain containing 6 14 51025604, 51188325 AL040051 14q22.1 Hs.434914 9

binding

cytoplasm

mitochondrion

cytoskeleton

plasma membrane

 
203441_s_at CDH2 cadherin 2, type 1, N-cadherin (neuronal) 18 -23784927 NM_001792 18q11.2 Hs.464829 Hs.606106 102

calcium ion binding

plasma membrane

adherens junction

cell adhesion

homophilic cell adhesion

heterophilic cell adhesion

synaptogenesis

integral to membrane

calcium-dependent cell-cell adhesion

cell migration

protein phosphatase binding

lamellipodium

RPTP-like protein binding

synapse

blood vessel morphogenesis

Cell adhesion molecules (CAMs)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

205856_at SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 18 41558089, 41560915 NM_015865 18q11-q12 Hs.101307 27

plasma membrane

integral to plasma membrane

transport

urea transmembrane transporter activity

urea transport

ubiquitin-ubiquitin ligase activity

 
206857_s_at 0.436 4.192 3.013 8.622e-03 0.391 -2.430 FKBP1B FK506 binding protein 1B, 12.6 kDa 2 24126087 NM_004116 2p23.3 Hs.709461 26

peptidyl-prolyl cis-trans isomerase activity

receptor binding

ryanodine-sensitive calcium-release channel activity

FK506 binding

cytoplasm

cytosol

'de novo' protein folding

muscle contraction

negative regulation of heart rate

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

isomerase activity

protein maturation by protein folding

regulation of calcium ion transport via store-operated calcium channel activity

negative regulation of protein phosphatase type 2B activity

calcium channel complex

protein refolding

response to redox state

regulation of ryanodine-sensitive calcium-release channel activity

regulation of ryanodine-sensitive calcium-release channel activity

 
219107_at BCAN brevican 1 154878363, 154878363 NM_021948 1q31 Hs.516904 Hs.663621 17

binding

sugar binding

hyaluronic acid binding

extracellular region

proteinaceous extracellular matrix

cell adhesion

membrane

anchored to membrane

 
204863_s_at IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 5 -55272450 BE856546 5q11 Hs.532082 124

positive regulation of acute inflammatory response

positive regulation of adaptive immune response

receptor activity

ciliary neurotrophic factor receptor activity

interleukin-6 receptor activity

interleukin-6 receptor activity

interleukin-11 receptor activity

leukemia inhibitory factor receptor activity

oncostatin-M receptor activity

receptor binding

ciliary neurotrophic factor receptor binding

extracellular region

plasma membrane

interleukin-6 receptor complex

oncostatin-M receptor complex

glycogen metabolic process

signal transduction

positive regulation of cell proliferation

regulation of Notch signaling pathway

external side of plasma membrane

positive regulation vascular endothelial growth factor production

positive regulation of cardiac muscle hypertrophy

integral to membrane

response to cytokine stimulus

positive regulation of T cell proliferation

positive regulation of tyrosine phosphorylation of Stat1 protein

positive regulation of tyrosine phosphorylation of Stat3 protein

protein homodimerization activity

interleukin-27 receptor activity

positive regulation of osteoblast differentiation

positive regulation of anti-apoptosis

leukemia inhibitory factor signaling pathway

interleukin-27-mediated signaling pathway

ciliary neurotrophic factor receptor complex

ciliary neurotrophic factor-mediated signaling pathway

Cytokine-cytokine receptor interaction

Jak-STAT signaling pathway

241869_at APOL6 apolipoprotein L, 6 22 34374369 AW026509 22q12.3 Hs.257352 12

lipid transporter activity

extracellular region

cytoplasm

lipid transport

lipid binding

lipoprotein metabolic process

 
223012_at 0.508 8.695 2.659 1.769e-02 0.473 -3.039 UBXN6 UBX domain protein 6 19 -4396260 AF272894 19p13 Hs.435255 Hs.661664 6

molecular_function

protein binding

cellular_component

nucleus

cytoplasm

centrosome

biological_process

modification-dependent protein catabolic process

 
217800_s_at NDFIP1 Nedd4 family interacting protein 1 5 141468507 NM_030571 5q31.3 Hs.653510 Hs.9788 11

signal transducer activity

protein binding

Golgi apparatus

cellular iron ion homeostasis

negative regulation of gene expression

membrane

integral to membrane

positive regulation of protein ubiquitination

negative regulation of transporter activity

positive regulation of I-kappaB kinase/NF-kappaB cascade

perinuclear region of cytoplasm

negative regulation of protein transport

 
205788_s_at ZC3H11A zinc finger CCCH-type containing 11A 1 202031373 NM_014827 1q32.1 Hs.532399 13

nucleic acid binding

protein binding

zinc ion binding

metal ion binding

 
205727_at TEP1 telomerase-associated protein 1 14 -19903666 NM_007110 14q11.2 Hs.508835 19

nucleotide binding

telomere maintenance via recombination

chromosome, telomeric region

telomerase activity

RNA binding

ATP binding

soluble fraction

nucleus

chromosome

telomerase holoenzyme complex

cytoplasm

nuclear matrix

 
203877_at MMP11 matrix metallopeptidase 11 (stromelysin 3) 22 22445035 NM_005940 22q11.2 22q11.23 Hs.143751 30

metalloendopeptidase activity

calcium ion binding

extracellular region

proteinaceous extracellular matrix

proteolysis

multicellular organismal development

peptidase activity

zinc ion binding

collagen catabolic process

 
225056_at -1.110 6.453 -4.211 7.351e-04 0.211 -0.341 SIPA1L2 signal-induced proliferation-associated 1 like 2 1 -230600334 AB037810 1q42.2 Hs.715656 8

GTPase activator activity

protein binding

intracellular

regulation of small GTPase mediated signal transduction

 
237388_at GLMN glomulin, FKBP associated protein 1 -92484542 BF224204 1p22.1 Hs.49105 14

vasculogenesis

hepatocyte growth factor receptor binding

protein binding

protein binding

intracellular

regulation of gene expression, epigenetic

negative regulation of T cell proliferation

positive regulation of phosphorylation

muscle cell differentiation

positive regulation of interleukin-2 biosynthetic process

positive regulation of cytokine secretion

 
202866_at 0.245 7.302 2.223 4.174e-02 0.574 -3.755 DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 10 -73762593 BG283782 10q22.1 Hs.696014 7

endoplasmic reticulum

protein folding

membrane

integral to membrane

heat shock protein binding

unfolded protein binding

 
203983_at TSNAX translin-associated factor X 1 229731021 NM_005999 1q42.1 Hs.96247 17

nucleus

cytoplasm

multicellular organismal development

spermatogenesis

protein transporter activity

cell differentiation

sequence-specific DNA binding

perinuclear region of cytoplasm

 
1559646_a_at NCRNA00184 non-protein coding RNA 184 1   AJ421679 1q42.3 Hs.209162      
203573_s_at RABGGTA Rab geranylgeranyltransferase, alpha subunit 14 -23804583, -23804583 NM_004581 14q11.2 Hs.377992 14

Rab geranylgeranyltransferase activity

protein binding

protein modification process

visual perception

zinc ion binding

protein prenyltransferase activity

transferase activity

protein geranylgeranylation

protein amino acid prenylation

metal ion binding

 
225044_at 0.357 7.299 2.758 1.450e-02 0.447 -2.871 NT5C3L 5'-nucleotidase, cytosolic III-like 17 -37234948 AL526783 17q21.2 Hs.237536 1

nucleotide binding

magnesium ion binding

cytoplasm

5'-nucleotidase activity

nucleotide metabolic process

transferase activity

hydrolase activity

 
239247_at LOC401577 hypothetical protein LOC401577 X, Y   AI972146 Xp22.33 Yp11.31 Hs.444541 2    
227462_at 1.639 5.640 2.419 2.856e-02 0.532 -3.441 ERAP2 endoplasmic reticulum aminopeptidase 2 5 96237399 BE889628 5q15 Hs.482910 14

aminopeptidase activity

endoplasmic reticulum

endoplasmic reticulum lumen

proteolysis

immune response

regulation of blood pressure

peptidase activity

metallopeptidase activity

zinc ion binding

membrane

integral to membrane

antigen processing and presentation of endogenous peptide antigen via MHC class I

metal ion binding

 
208274_at -0.250 4.639 -2.364 3.176e-02 0.544 -3.529 OCLM oculomedin 1 184636326 NM_022375 1q25 Hs.679230 6

visual perception

 
233587_s_at -1.041 5.782 -4.798 2.261e-04 0.172 0.642 SIPA1L2 signal-induced proliferation-associated 1 like 2 1 -230600334 AK022852 1q42.2 Hs.715656 8

GTPase activator activity

protein binding

intracellular

regulation of small GTPase mediated signal transduction

 
228593_at MTMR9L myotubularin related protein 9-like 1 -32469848 AI271425 1p35.1 Hs.471067 3    
233566_at LOC84856 hypothetical LOC84856 10 42290944 AK024638 10q11.21 Hs.55977 3    
202288_at MTOR mechanistic target of rapamycin (serine/threonine kinase) 1 -11089175 U88966 1p36.2 Hs.338207 317

nucleotide binding

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

cytoplasm

mitochondrion

mitochondrial outer membrane

endoplasmic reticulum

Golgi apparatus

cytosol

phosphoinositide 3-kinase complex

signal transduction

response to nutrient

endomembrane system

membrane

cell growth

kinase activity

phosphotransferase activity, alcohol group as acceptor

protein catabolic process

TOR signaling pathway

TORC1 complex

TORC2 complex

regulation of actin cytoskeleton organization

response to amino acid stimulus

protein amino acid autophosphorylation

phosphoprotein binding

ErbB signaling pathway

mTOR signaling pathway

Insulin signaling pathway

Adipocytokine signaling pathway

Type II diabetes mellitus

Pathways in cancer

Glioma

Prostate cancer

Acute myeloid leukemia

203341_at CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2 -37282278 NM_005760 2p22.2 Hs.135406 14

DNA binding

binding

nucleus

transcription from RNA polymerase II promoter

regulation of transcription

 
223209_s_at SELS selenoprotein S 15 -99629912, -99628736 AF328864 15q26.3 Hs.32148 33

receptor activity

endoplasmic reticulum

anti-apoptosis

inflammatory response

redox signal response

ER overload response

selenium binding

response to glucose stimulus

membrane

integral to membrane

antioxidant activity

enzyme binding

integral to endoplasmic reticulum membrane

ER-associated protein catabolic process

endoplasmic reticulum unfolded protein response

retrograde protein transport, ER to cytosol

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

very-low-density lipoprotein particle

low-density lipoprotein particle

establishment of protein localization

cell redox homeostasis

 
239720_at GLP-1 GATA like protein-1 19 -10276478 AI923985 19p13.2 Hs.709296 11

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
208698_s_at NONO non-POU domain containing, octamer-binding X 70419766 L14599 Xq13.1 Hs.533282 Hs.700344 46

nucleotide binding

DNA binding

RNA binding

nucleus

DNA repair

DNA recombination

mRNA processing

response to DNA damage stimulus

RNA splicing

identical protein binding

regulation of transcription

 
221514_at 0.335 5.742 2.197 4.395e-02 0.579 -3.798 UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) X 128867839 BC001149 Xq26.1 Hs.458598 12

protein binding

nucleus

nucleolus

rRNA processing

small-subunit processome

 
1553391_at -0.311 2.680 -2.498 2.443e-02 0.513 -3.310 CXorf58 chromosome X open reading frame 58 X 23836043 NM_152761 Xp22.11 Hs.351265 4    
226035_at USP31 ubiquitin specific peptidase 31 16 -22980228 AA102581 16p12.2 Hs.183817 8

ubiquitin thiolesterase activity

ubiquitin-dependent protein catabolic process

peptidase activity

cysteine-type peptidase activity

 
213688_at 0.269 4.880 2.193 4.422e-02 0.579 -3.803 CALM1 calmodulin 1 (phosphorylase kinase, delta) 14 89933125 N25325 14q24-q31 Hs.282410 Hs.708270 181  

Calcium signaling pathway

Phosphatidylinositol signaling system

Vascular smooth muscle contraction

Long-term potentiation

Neurotrophin signaling pathway

Olfactory transduction

Insulin signaling pathway

GnRH signaling pathway

Melanogenesis

Alzheimer's disease

Glioma

230679_at -0.313 3.507 -2.224 4.173e-02 0.574 -3.755 DCAF10 DDB1 and CUL4 associated factor 10 9 37790789 AA976778 9p13.2 Hs.118394 2    
217069_at MLL4 myeloid/lymphoid or mixed-lineage leukemia 4 19 40900760 AF105279 19q13.1 Hs.676457 Hs.92236 15

transcription factor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

methyltransferase activity

zinc ion binding

chromatin modification

transferase activity

histone methyltransferase complex

histone methyltransferase activity (H3-K4 specific)

metal ion binding

chromatin-mediated maintenance of transcription

 
234854_at MDN1 MDN1, midasin homolog (yeast) 6 -90409951 AL096678 6q15 Hs.529948 7

nucleotide binding

ATP binding

nucleus

ATPase activity

regulation of protein complex assembly

unfolded protein binding

 
225464_at FRMD6 FERM domain containing 6 14 51025604, 51188325 N30138 14q22.1 Hs.434914 9

binding

cytoplasm

mitochondrion

cytoskeleton

plasma membrane

 
221168_at -0.249 3.146 -2.456 2.652e-02 0.522 -3.379 PRDM13 PR domain containing 13 6 100161370 NM_021620 6q16-q21 Hs.287386 3

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
207081_s_at PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 22 -19391978, -19391978 NM_002650 22q11.21 Hs.529438 29

nucleotide binding

1-phosphatidylinositol 4-kinase activity

protein binding

ATP binding

Golgi-associated vesicle

phosphatidylinositol biosynthetic process

signal transduction

synaptic transmission

transferase activity

phosphoinositide phosphorylation

phosphoinositide-mediated signaling

Inositol phosphate metabolism

Metabolic pathways

Phosphatidylinositol signaling system

1569827_at ATG7 ATG7 autophagy related 7 homolog (S. cerevisiae) 3 11289009 BE048026 3p25.3 Hs.716466 15

catalytic activity

ubiquitin activating enzyme activity

protein binding

cytoplasm

protein amino acid lipidation

autophagy

membrane fusion

metabolic process

protein transport

modification-dependent protein catabolic process

positive regulation of protein modification process

protein homodimerization activity

Regulation of autophagy

211505_s_at STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) 20 -47163282 AL136601 20q13.1 Hs.596704 26

double-stranded RNA binding

protein binding

intracellular

rough endoplasmic reticulum

microtubule associated complex

intracellular mRNA localization

ribonucleoprotein complex

 
208867_s_at CSNK1A1 casein kinase 1, alpha 1 5 -148855037 AF119911 5q32 Hs.529862 Hs.712555 53

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

cytosol

protein amino acid phosphorylation

Wnt receptor signaling pathway

transferase activity

Wnt signaling pathway

Hedgehog signaling pathway

224862_at GNAQ guanine nucleotide binding protein (G protein), q polypeptide 9 -79525010 BF969428 9q21 Hs.269782 105

nucleotide binding

skeletal system development

regulation of action potential

GTPase activity

signal transducer activity

protein binding

GTP binding

membrane fraction

cytoplasm

plasma membrane

plasma membrane

protein amino acid ADP-ribosylation

signal transduction

G-protein coupled receptor protein signaling pathway

activation of adenylate cyclase activity by G-protein signaling pathway

activation of phospholipase C activity

glutamate signaling pathway

heart development

blood coagulation

behavior

post-embryonic development

neuron remodeling

guanyl nucleotide binding

forebrain neuron development

embryonic digit morphogenesis

regulation of melanocyte differentiation

pigmentation during development

activation of phospholipase C activity by dopamine receptor signaling pathway

Calcium signaling pathway

Vascular smooth muscle contraction

Gap junction

Long-term potentiation

Long-term depression

GnRH signaling pathway

Melanogenesis

Alzheimer's disease

Huntington's disease

224282_s_at AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 21 44109543, 44169706 AB040138 21q22.3 Hs.248785 9

1-acylglycerol-3-phosphate O-acyltransferase activity

endoplasmic reticulum

cytosol

plasma membrane

metabolic process

acyltransferase activity

phospholipid biosynthetic process

integral to membrane

transferase activity

phospholipid:diacylglycerol acyltransferase activity

Glycerolipid metabolism

Glycerophospholipid metabolism

Ether lipid metabolism

Metabolic pathways

218320_s_at NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa X -46886559, -46886559 NM_019056 Xp11.23 Hs.521969 9

mitochondrion

mitochondrial inner membrane

transport

membrane

integral to membrane

electron transport chain

respiratory chain

 
224763_at 0.334 6.833 2.192 4.431e-02 0.579 -3.804 RPL37 ribosomal protein L37 5 -40867186 BF724210 5p13 Hs.558601 Hs.80545 12

structural constituent of ribosome

protein binding

intracellular

cytosol

ribosome

translational elongation

zinc ion binding

rRNA binding

cytosolic large ribosomal subunit

metal ion binding

Ribosome

214340_at ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2 17 6697618 AF020774 17p13 Hs.378695 3    
39854_r_at -0.248 8.559 -2.174 4.586e-02 0.581 -3.833 PNPLA2 patatin-like phospholipase domain containing 2 11 808901 AF055000 11p15.5 Hs.654697 30

triacylglycerol lipase activity

lipid particle

plasma membrane

metabolic process

negative regulation of sequestering of triglyceride

positive regulation of triglyceride catabolic process

integral to membrane

lipid catabolic process

hydrolase activity

 
212402_at ZC3H13 zinc finger CCCH-type containing 13 13 -45434314 BE895685 13q14.13 Hs.136102 11

nucleic acid binding

zinc ion binding

metal ion binding

 
214587_at -0.263 2.318 -3.271 5.072e-03 0.345 -1.979 COL8A1 collagen, type VIII, alpha 1 3 100840143 BE877796 3q12.3 Hs.654548 16

protein binding

extracellular region

collagen type VIII

basement membrane

cell adhesion

positive regulation of cell-substrate adhesion

camera-type eye morphogenesis

epithelial cell proliferation

 
1558768_at DNAH1 dynein, axonemal, heavy chain 1 3 52325374 AB037831 3p21.1 Hs.655469 7

nucleotide binding

ciliary or flagellar motility

microtubule motor activity

ATP binding

axonemal dynein complex

microtubule

cilium

microtubule-based movement

ATPase activity

cilium axoneme

Huntington's disease

227632_at TBC1D24 TBC1 domain family, member 24 16 2465147 N74056 16p13.3 Hs.353087 3

GTPase activator activity

Rab GTPase activator activity

intracellular

regulation of Rab GTPase activity

 
208111_at AVPR2 arginine vasopressin receptor 2 X 152821178, 152823722 NM_000054 Xq28 Hs.567240 85

receptor activity

G-protein coupled receptor activity

vasopressin receptor activity

endosome

endoplasmic reticulum

Golgi apparatus

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

G-protein signaling, coupled to cAMP nucleotide second messenger

activation of adenylate cyclase activity

excretion

hemostasis

positive regulation of gene expression

Neuroactive ligand-receptor interaction

224974_at SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 12 117298740 AK024460 12q24.23 Hs.416630 Hs.602312 9

protein binding

negative regulation of transcription

chromatin modification

Sin3 complex

histone deacetylase binding

 
214229_at -0.177 3.405 -2.215 4.239e-02 0.575 -3.768 DNAH17 dynein, axonemal, heavy chain 17 17   AL122077 17q25.3 Hs.375975 Hs.713207 7

nucleotide binding

ciliary or flagellar motility

microtubule motor activity

ATP binding

axonemal dynein complex

microtubule

cilium

microtubule-based movement

ATPase activity

cilium axoneme

 
238444_at ZNF618 zinc finger protein 618 9 115678382 AV704303 9q32 Hs.349208 2

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

protein dimerization activity

 
220510_at RHBG Rh family, B glycoprotein (gene/pseudogene) 1 154605626 NM_020407 1q21.3 Hs.131835 16

plasma membrane

integral to plasma membrane

transport

ammonium transmembrane transporter activity

spectrin-associated cytoskeleton

basolateral plasma membrane

basolateral plasma membrane

ankyrin binding

cytoplasmic vesicle

anchored to plasma membrane

ammonia transporter activity

ammonia transporter activity

transepithelial ammonium transport

 
232705_at LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 3 -37069120 AK025207 3p22.2 Hs.719246 7

protein binding

cellular_component

biological_process

Wnt receptor signaling pathway

LRR domain binding

 
218989_x_at 0.337 5.463 2.237 4.063e-02 0.570 -3.733 SLC30A5 solute carrier family 30 (zinc transporter), member 5 5 68425573, 68425637 NM_022902 5q12.1 Hs.631975 10

zinc ion transmembrane transporter activity

membrane fraction

Golgi apparatus

integral to plasma membrane

cation transport

cobalt ion transport

zinc ion transport

cellular zinc ion homeostasis

zinc ion binding

cation transmembrane transporter activity

response to zinc ion

regulation of proton transport

membrane

apical plasma membrane

secretory granule

 
205028_at TRO trophinin X 54963973, 54963973 NM_016157 Xp11.22-p11.21 Hs.633653 26

protein binding

plasma membrane

integral to plasma membrane

cell adhesion

homophilic cell adhesion

embryo implantation

 
1553362_at DNAH6 dynein, axonemal, heavy chain 6 2 84597089 NM_173645 2p11.2 Hs.249972 7

nucleotide binding

microtubule motor activity

ATP binding

microtubule

microtubule-based movement

ATPase activity

dynein complex

 
207237_at -0.173 2.950 -2.301 3.592e-02 0.557 -3.631 KCNA3 potassium voltage-gated channel, shaker-related subfamily, member 3 1 -111015832 NM_002232 1p13.3 Hs.169948 35

voltage-gated ion channel activity

delayed rectifier potassium channel activity

protein binding

ion transport

potassium ion transport

voltage-gated potassium channel complex

outward rectifier potassium channel activity

membrane

integral to membrane

potassium ion binding

 
207214_at SPINK4 serine peptidase inhibitor, Kazal type 4 9 33230195 NM_014471 9p13.3 Hs.555934 7

serine-type endopeptidase inhibitor activity

extracellular region

nucleus

peptidase inhibitor activity

 
235114_x_at HOOK3 hook homolog 3 (Drosophila) 8 42871189 N67300 8p11.21 Hs.162852 13

cytoplasm

Golgi apparatus

cis-Golgi network

cytoskeleton

microtubule

endosome organization

lysosome organization

microtubule binding

endosome to lysosome transport

protein transport

HOPS complex

cytoplasmic microtubule organization

identical protein binding

early endosome to late endosome transport

Golgi localization

FHF complex

 
209147_s_at PPAP2A phosphatidic acid phosphatase type 2A 5 -54756439 AB000888 5q11 Hs.696231 20

membrane fraction

cytosol

plasma membrane

integral to plasma membrane

activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway

phosphatidate phosphatase activity

phosphatidate phosphatase activity

phosphatidate phosphatase activity

negative regulation of cell proliferation

germ cell migration

hydrolase activity

regulation of lipid metabolic process

androgen receptor signaling pathway

phospholipid dephosphorylation

Glycerolipid metabolism

Glycerophospholipid metabolism

Ether lipid metabolism

Sphingolipid metabolism

Metabolic pathways

Fc gamma R-mediated phagocytosis

225045_at CCDC88A coiled-coil domain containing 88A 2 -55368483 AB033038 2p16.1 Hs.292925 13

regulation of protein amino acid phosphorylation

actin binding

cytoplasm

endoplasmic reticulum

Golgi apparatus

cytosol

plasma membrane

regulation of DNA replication

microtubule binding

membrane organization

cell migration

lamellipodium

lamellipodium assembly

cytoplasmic vesicle

activation of protein kinase B activity

regulation of actin cytoskeleton organization

phosphoinositide binding

regulation of cell proliferation

protein homodimerization activity

protein kinase B binding

 
237470_at DOCK7 dedicator of cytokinesis 7 1 -62692984 R45067 1p31.3 Hs.406156 15

microtubule cytoskeleton organization

guanyl-nucleotide exchange factor activity

GTP binding

multicellular organismal development

nervous system development

axonogenesis

cell differentiation

axon

growth cone

neuron projection development

activation of Rac GTPase activity

positive regulation of peptidyl-serine phosphorylation

basal part of cell

establishment of neuroblast polarity

Rac GTPase binding

GTPase binding

 
1554415_at TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 1 -227801563, -227795486 BC041094 1q42.13 Hs.270621 16

transcription factor activity

transcription coactivator activity

histone acetyltransferase activity

nucleus

transcription from RNA polymerase II promoter

STAGA complex

transcription factor TFTC complex

histone H3 acetylation

regulation of transcription

Basal transcription factors

1569354_at NSUN6 NOL1/NOP2/Sun domain family, member 6 10 -18874269 BC033534 10p12.31 Hs.396175 4

RNA binding

methyltransferase activity

transferase activity

 
213927_at MAP3K9 mitogen-activated protein kinase kinase kinase 9 14 -70264606 AV753204 14q24.3-q31 Hs.445496 Hs.593542 9

nucleotide binding

protein serine/threonine kinase activity

JUN kinase kinase kinase activity

MAP kinase kinase activity

protein tyrosine kinase activity

ATP binding

cellular_component

activation of JUN kinase activity

transferase activity

protein homodimerization activity

protein amino acid autophosphorylation

 
204469_at -0.214 2.139 -2.166 4.656e-02 0.582 -3.845 PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 7 121300394 NM_002851 7q31.3 Hs.489824 42

transmembrane receptor protein tyrosine phosphatase activity

protein binding

cellular_component

integral to plasma membrane

protein amino acid dephosphorylation

central nervous system development

biological_process

protein tyrosine/threonine phosphatase activity

membrane

hydrolase activity

Epithelial cell signaling in Helicobacter pylori infection

217503_at STK17B serine/threonine kinase 17b 2 -196706552 AA203487 2q32.3 Hs.710234 Hs.88297 7

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

protein amino acid phosphorylation

apoptosis

induction of apoptosis

protein kinase cascade

actin cytoskeleton

transferase activity

 
221687_s_at FAM125B family with sequence similarity 125, member B 9 128128948, 128128948 BC000122 9q33.3 Hs.162659 4

endosome

protein transport

membrane

Endocytosis

1556804_s_at 0.418 2.600 2.324 3.438e-02 0.553 -3.595 POLR3B polymerase (RNA) III (DNA directed) polypeptide B 12 105275565, 105275989 BC033542 12q23.3 Hs.610795 Hs.62696 8

DNA binding

DNA-directed RNA polymerase activity

nucleus

transcription

zinc ion binding

transferase activity

nucleotidyltransferase activity

ribonucleoside binding

metal ion binding

Purine metabolism

Pyrimidine metabolism

Metabolic pathways

RNA polymerase

214356_s_at KIAA0368 KIAA0368 9 -113162793 AI272899 9q31.3 Hs.368255 12

proteasome complex

binding

nucleus

early endosome

late endosome

endoplasmic reticulum

ER-Golgi intermediate compartment

trans-Golgi network

centrosome

cytosol

cytoplasmic membrane-bounded vesicle

ER to Golgi transport vesicle

ER-associated protein catabolic process

 
239546_at LOC100131053 hypothetical LOC100131053 1   AA404325 1p36.13 Hs.697104 1    
222415_at MLL3 myeloid/lymphoid or mixed-lineage leukemia 3 7 -151462942 BE962679 7q36.1 Hs.647120 21

DNA binding

protein binding

nucleus

regulation of transcription, DNA-dependent

intracellular signaling cascade

methyltransferase activity

zinc ion binding

chromatin modification

transferase activity

histone-lysine N-methyltransferase activity

metal ion binding

 
200985_s_at CD59 CD59 molecule, complement regulatory protein 11 -33681131, -33681131, -33681131 NM_000611 11p13 Hs.278573 Hs.709466 Hs.710641 107

protein binding

extracellular region

membrane fraction

plasma membrane

cell surface receptor linked signal transduction

blood coagulation

anchored to membrane

anchored to external side of plasma membrane

Complement and coagulation cascades

Hematopoietic cell lineage

227781_x_at FAM57B family with sequence similarity 57, member B 16 -29943248 AL565715 16p11.2 Hs.558560 8

endoplasmic reticulum

membrane

integral to membrane

 
225368_at HIPK2 homeodomain interacting protein kinase 2 7 -138896855 BF218115 7q32-q34 Hs.397465 Hs.632033 66

nucleotide binding

transcription corepressor activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

cytoplasm

centrosome

protein amino acid phosphorylation

apoptosis

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

induction of apoptosis by intracellular signals

PML body

transferase activity

virus-host interaction

positive regulation of transforming growth factor beta receptor signaling pathway

nuclear membrane

regulation of transcription

positive regulation of transcription, DNA-dependent

positive regulation of JNK cascade

virion binding

 
225189_s_at RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 -204014436, -204006783 AA194149 2q33 Hs.471162 13

nucleus

cytoplasm

cytoskeleton

plasma membrane

cell-matrix adhesion

signal transduction

lamellipodium

filopodium

 
202233_s_at UQCRH ubiquinol-cytochrome c reductase hinge protein 1 46541966 NM_006004 1p34.1 Hs.481571 9

mitochondrion

mitochondrial respiratory chain

oxidative phosphorylation

mitochondrial electron transport, ubiquinol to cytochrome c

transport

ubiquinol-cytochrome-c reductase activity

aerobic respiration

membrane

electron transport chain

Oxidative phosphorylation

Metabolic pathways

Cardiac muscle contraction

Alzheimer's disease

Parkinson's disease

Huntington's disease

201618_x_at 0.268 7.420 2.471 2.575e-02 0.517 -3.354 GPAA1 glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) 8 145209511 NM_003801 8q24.3 Hs.627962 16

GPI-anchor transamidase activity

protein binding

endoplasmic reticulum

protein complex assembly

protein retention in ER lumen

tubulin binding

membrane

integral to membrane

attachment of GPI anchor to protein

attachment of GPI anchor to protein

attachment of GPI anchor to protein

GPI anchor binding

GPI-anchor transamidase complex

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

Metabolic pathways

1553555_at -0.368 4.425 -2.876 1.141e-02 0.426 -2.668 TAS2R38 taste receptor, type 2, member 38 7 -141318899 NM_176817 7q34 Hs.647085 29

receptor activity

G-protein coupled receptor activity

signal transduction

G-protein coupled receptor protein signaling pathway

membrane

integral to membrane

response to stimulus

sensory perception of taste

Taste transduction

1569938_at SIRT5 sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) 6 13682770, 13682853 BC035196 6p23 Hs.567431 Hs.594133 13

NAD+ ADP-ribosyltransferase activity

mitochondrion

chromatin silencing

protein amino acid ADP-ribosylation

protein amino acid deacetylation

zinc ion binding

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

regulation of transcription

metal ion binding

NAD binding

 
219574_at MARCH1 membrane-associated ring finger (C3HC4) 1 4 -164668498 NM_017923 4q32.2-q32.3 Hs.608487 Hs.696248 5

zinc ion binding

membrane

integral to membrane

ligase activity

modification-dependent protein catabolic process

cytoplasmic vesicle

metal ion binding

 
209527_at EXOSC2 exosome component 2 9 132558978 BC000747 9q34 Hs.654643 32

3'-5'-exoribonuclease activity

exosome (RNase complex)

exonuclease activity

protein binding

nucleus

nucleolus

cytoplasm

rRNA processing

7S RNA binding

hydrolase activity

RNA degradation

227672_at C8orf73 chromosome 8 open reading frame 73 8 -144719505 W67308 8q24.3 Hs.531406 3

binding

Golgi apparatus

 
222634_s_at 0.462 4.726 2.604 1.979e-02 0.491 -3.133 TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 3 -178221235 AF314544 3q26.32 Hs.715537 14

nucleus

chromatin modification

modification-dependent protein catabolic process

regulation of transcription

Wnt signaling pathway

227845_s_at SHD Src homology 2 domain containing transforming protein D 19 4229597 AW452918 19p13.3 Hs.7423 5

protein binding

 
226925_at 0.491 5.058 2.421 2.844e-02 0.532 -3.437 ACPL2 acid phosphatase-like 2 3 142433371 AW069729 3q23 Hs.657887 2

acid phosphatase activity

extracellular region

hydrolase activity

 
1570035_at TBC1D10A TBC1 domain family, member 10A 22 -29017978 BC007908 22q12.1-qter Hs.655273 13

Rab GTPase activator activity

protein binding

intracellular

microvillus

biological_process

PDZ domain binding

regulation of Rab GTPase activity

 
221237_s_at OSBP2 oxysterol binding protein 2 22 29420792 NM_030758 22q12.2 Hs.517546 11

lipid transport

steroid metabolic process

membrane

 
221732_at -0.310 7.107 -2.585 2.055e-02 0.496 -3.165 CANT1 calcium activated nucleotidase 1 17 -74499392 AK026161 17q25.3 Hs.8859 13

signal transducer activity

calcium ion binding

endoplasmic reticulum

Golgi apparatus

membrane

integral to membrane

hydrolase activity

nucleoside-diphosphatase activity

positive regulation of I-kappaB kinase/NF-kappaB cascade

Purine metabolism

Pyrimidine metabolism

204528_s_at NAP1L1 nucleosome assembly protein 1-like 1 12 -74724938 NM_004537 12q21.2 Hs.524599 Hs.695185 17

protein binding

nucleus

chromatin assembly complex

DNA replication

nucleosome assembly

positive regulation of cell proliferation

melanosome

 
236292_at RNF130 ring finger protein 130 5 -179315079 AW196696 5q35.3 Hs.484363 7

molecular_function

protein binding

apoptosis

zinc ion binding

membrane

integral to membrane

metal ion binding

 
225302_at 0.363 7.086 2.482 2.522e-02 0.514 -3.337 TMX3 thioredoxin-related transmembrane protein 3 18 -64491904 BE503286 18q22 Hs.440534 11

protein disulfide isomerase activity

endoplasmic reticulum

membrane

integral to membrane

isomerase activity

cell redox homeostasis

 
216763_at -0.275 3.520 -2.508 2.394e-02 0.509 -3.293 KANK1 KN motif and ankyrin repeat domains 1 9 494702, 696895 AK025097 9p24.3 Hs.306764 14

cytoplasm

 
242469_at -0.260 5.067 -2.791 1.357e-02 0.438 -2.815 LOC120376 Uncharacterized protein LOC120376 11 110675185 AI590055 11q23.1 Hs.31409 6    
214756_x_at PMS2L1 postmeiotic segregation increased 2-like 1 pseudogene 7 -99756198 AB017004 7q22.1 Hs.634244 Hs.661055 Hs.709266 7

molecular_function

ATP binding

cellular_component

mismatch repair

biological_process

kinase activity

transferase activity

mismatched DNA binding

 
227239_at FAM126A family with sequence similarity 126, member A 7 -22947402 AV734839 7p15.3 Hs.85603 9

signal transducer activity

cellular_component

cytoplasm

biological_process

membrane

 
201950_x_at CAPZB capping protein (actin filament) muscle Z-line, beta 1 -19537859 NM_004930 1p36.1 Hs.432760 10

actin binding

protein binding

cytoplasm

cell motion

F-actin capping protein complex

actin cytoskeleton organization

actin filament capping

 
243829_at BRAF v-raf murine sarcoma viral oncogene homolog B1 7 -140080281 AW613053 7q34 Hs.550061 427

nucleotide binding

protein serine/threonine kinase activity

receptor signaling protein activity

protein binding

ATP binding

nucleus

cytoplasm

plasma membrane

protein amino acid phosphorylation

anti-apoptosis

small GTPase mediated signal transduction

zinc ion binding

organ morphogenesis

transferase activity

diacylglycerol binding

metal ion binding

MAPK signaling pathway

ErbB signaling pathway

Chemokine signaling pathway

mTOR signaling pathway

Vascular smooth muscle contraction

Focal adhesion

Natural killer cell mediated cytotoxicity

Long-term potentiation

Neurotrophin signaling pathway

Long-term depression

Regulation of actin cytoskeleton

Insulin signaling pathway

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Endometrial cancer

Glioma

Prostate cancer

Thyroid cancer

Melanoma

Bladder cancer

Chronic myeloid leukemia

Acute myeloid leukemia

Non-small cell lung cancer

219415_at TTYH1 tweety homolog 1 (Drosophila) 19 59618446 NM_020659 19q13.4 Hs.268728 4

ion channel activity

chloride channel activity

iron ion transmembrane transporter activity

protein binding

plasma membrane

ion transport

iron ion transport

cell adhesion

integral to membrane

chloride ion binding

chloride channel complex

 
212776_s_at OBSL1 obscurin-like 1 2 -220123708 AI978623 2q35 Hs.526594 10

cytoskeleton organization

cytoskeletal adaptor activity

intercalated disc

Z disc

M band

perinuclear region of cytoplasm

cardiac myofibril assembly

 
243313_at SYNPO2L synaptopodin 2-like 10 -75074649, -75074649 AI141151 10q22.2 Hs.645273 4

actin binding

protein binding

cytoplasm

cytoskeleton

 
212919_at DCP2 DCP2 decapping enzyme homolog (S. cerevisiae) 5 112340331 AV715578 5q22.2 Hs.443875 21

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

cytoplasmic mRNA processing body

RNA binding

protein binding

nucleus

cytoplasm

hydrolase activity

manganese ion binding

metal ion binding

RNA degradation

200642_at 0.287 11.065 2.420 2.847e-02 0.532 -3.438 SOD1 superoxide dismutase 1, soluble 21 31953805 NM_000454 21q22.1 21q22.11 Hs.443914 450

activation of MAPK activity

response to superoxide

ovarian follicle development

positive regulation of cytokine production

placenta development

retina homeostasis

myeloid cell homeostasis

superoxide dismutase activity

copper ion binding

extracellular space

nucleus

cytoplasm

mitochondrion

mitochondrial matrix

peroxisome

cytosol

plasma membrane

double-strand break repair

DNA fragmentation involved in apoptosis

glutathione metabolic process

cellular iron ion homeostasis

anti-apoptosis

spermatogenesis

embryo implantation

embryo implantation

cell aging

cell aging

sensory perception of sound

locomotory behavior

regulation of blood pressure

cell death

zinc ion binding

response to heat

antioxidant activity

oxidoreductase activity

transmission of nerve impulse

removal of superoxide radicals

protein phosphatase 2B binding

extracellular matrix

cytoplasmic vesicle

response to nutrient levels

myelin maintenance in the peripheral nervous system

dendrite cytoplasm

regulation of T cell differentiation in the thymus

regulation of multicellular organism growth

response to drug

response to hydrogen peroxide

superoxide anion generation

protein homodimerization activity

cell soma

positive regulation of apoptosis

positive regulation of catalytic activity

protein complex

negative regulation of neuron apoptosis

response to ethanol

negative regulation of cholesterol biosynthetic process

regulation of protein kinase activity

regulation of organ growth

response to copper ion

muscle maintenance

metal ion binding

thymus development

response to axon injury

hydrogen peroxide biosynthetic process

hydrogen peroxide biosynthetic process

chaperone binding

regulation of mitochondrial membrane potential

oxidation reduction

heart contraction

neurofilament cytoskeleton organization

relaxation of vascular smooth muscle

auditory receptor cell stereocilium organization

Amyotrophic lateral sclerosis (ALS)

Huntington's disease

Prion diseases

238765_at ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 9 116389814 AA732007 9q32 Hs.388654 18

protein binding

intracellular

lysosomal membrane

cytosol

plasma membrane

plasma membrane

ion transport

hydrogen-exporting ATPase activity, phosphorylative mechanism

proton transport

vacuolar proton-transporting V-type ATPase complex

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

ATPase activity

ATPase binding

Oxidative phosphorylation

Metabolic pathways

Vibrio cholerae infection

Epithelial cell signaling in Helicobacter pylori infection

218154_at GSDMD gasdermin D 8 144711634 NM_024736 8q24.3 Hs.118983 8

cellular response to extracellular stimulus

 
205022_s_at FOXN3 forkhead box N3 14 -88692268, -88692268 NM_005197 14q31.3 Hs.434286 Hs.621371 16

DNA damage checkpoint

G2 phase of mitotic cell cycle

transcription factor activity

nucleus

cell cycle

protein C-terminus binding

transcription repressor activity

sequence-specific DNA binding

negative regulation of transcription, DNA-dependent

 
235049_at -0.359 5.891 -2.356 3.229e-02 0.546 -3.543 ADCY1 adenylate cyclase 1 (brain) 7 45580649 AA021120 7p13-p12 Hs.192215 24

nucleotide binding

magnesium ion binding

calmodulin binding

ATP binding

cAMP biosynthetic process

long-term memory

calcium- and calmodulin-responsive adenylate cyclase activity

hormone-mediated signaling

membrane

integral to membrane

Purine metabolism

Calcium signaling pathway

Chemokine signaling pathway

Vascular smooth muscle contraction

Gap junction

Long-term potentiation

GnRH signaling pathway

Melanogenesis

214730_s_at GLG1 golgi apparatus protein 1 16 -73038828 AK025457 16q22.3 Hs.109731 17

Golgi membrane

receptor binding

Golgi apparatus

membrane

integral to membrane

Cell adhesion molecules (CAMs)

219457_s_at RIN3 Ras and Rab interactor 3 14 92049877 NM_024832 14q32.12 Hs.326822 8

GTPase activator activity

protein binding

cellular_component

cytoplasm

early endosome

endocytosis

signal transduction

Ras GTPase binding

cytoplasmic vesicle

 
219795_at -0.201 2.146 -2.174 4.585e-02 0.581 -3.833 SLC6A14 solute carrier family 6 (amino acid transporter), member 14 X 115481801 NM_007231 Xq23-q24 Hs.522109 13

neurotransmitter:sodium symporter activity

integral to plasma membrane

cellular amino acid metabolic process

neurotransmitter transport

amino acid transport

amino acid transmembrane transporter activity

symporter activity

membrane

brush border membrane

 
202589_at 0.554 3.988 2.770 1.417e-02 0.445 -2.851 TYMS thymidylate synthetase 18 647603 NM_001071 18p11.32 Hs.592338 260

thymidylate synthase activity

thymidylate synthase activity

cytosol

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

dTMP biosynthetic process

DNA replication

DNA repair

methyltransferase activity

deoxyribonucleoside monophosphate biosynthetic process

nucleotide biosynthetic process

transferase activity

response to organophosphorus

phosphoinositide-mediated signaling

Pyrimidine metabolism

One carbon pool by folate

Metabolic pathways

200748_s_at 0.545 12.251 3.473 3.347e-03 0.308 -1.625 FTH1 ferritin, heavy polypeptide 1 11 -61488332 NM_002032 11q13 Hs.524910 Hs.645560 55

ferroxidase activity

protein binding

iron ion transport

intracellular sequestering of iron ion

immune response

intracellular ferritin complex

ferric iron binding

negative regulation of cell proliferation

oxidoreductase activity

oxidation reduction

Porphyrin and chlorophyll metabolism

205489_at 2.640 7.246 4.200 7.505e-04 0.211 -0.358 CRYM crystallin, mu 16 -21177342, -21177342 NM_001888 16p13.11-p12.3 Hs.924 17

negative regulation of transcription from RNA polymerase II promoter

transcription corepressor activity

catalytic activity

cytoplasm

sensory perception of sound

metabolic process

thyroid hormone metabolic process

protein homodimerization activity

NADP or NADPH binding

thyroid hormone binding

thyroid hormone binding

thyroid hormone transport

 
213097_s_at DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 7 -102740156 AI338837 7q22 Hs.558476 11

DNA binding

nucleus

protein folding

heat shock protein binding

unfolded protein binding

 
235212_at C14orf102 chromosome 14 open reading frame 102 14 -89814150 AA346979 14q32.11 Hs.528131 4

protein binding

 
1554360_at FCHSD2 FCH and double SH3 domains 2 11 -72225437 BC010394 11q13.4 Hs.577053 9

protein binding

 
236523_at LOC285556 hypothetical protein LOC285556 4   BF435831 4q23 Hs.480371      
230645_at FRMD3 FERM domain containing 3 9 -85052126 BF110588 9q21.32 Hs.709357 7

binding

cytoplasm

cytoskeleton

cytoskeletal protein binding

membrane

integral to membrane

extrinsic to membrane

 
224163_s_at DMAP1 DNA methyltransferase 1 associated protein 1 1 44451711 AL136657 1p34 Hs.8008 24

DNA binding

protein binding

nucleus

DNA methylation

negative regulation of transcription

transcription repressor activity

chromatin modification

NuA4 histone acetyltransferase complex

regulation of growth

histone H4 acetylation

histone H2A acetylation

 
229861_at RFFL ring finger and FYVE-like domain containing 1 17 -30360243, -30360243 N66669 17q12 Hs.13680 11

protein binding

cytoplasm

intracellular protein transport

apoptosis

zinc ion binding

membrane

cytoplasmic membrane-bounded vesicle

ligase activity

modification-dependent protein catabolic process

metal ion binding

 
243365_s_at AUTS2 autism susceptibility candidate 2 7 68701840, 68701841, 68701841 AI417756 7q11.22 Hs.654801 Hs.712991 13

molecular_function

cellular_component

biological_process

 
204436_at PLEKHO2 pleckstrin homology domain containing, family O member 2 15 62921134 NM_025201 15q22.1 Hs.709337 2  

Cytokine-cytokine receptor interaction

201319_at MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 18 3237527 NM_006471 18p11.31 Hs.190086 9

motor activity

calcium ion binding

protein binding

myosin complex

Focal adhesion

Tight junction

Leukocyte transendothelial migration

Regulation of actin cytoskeleton

243311_at -0.207 3.671 -2.327 3.418e-02 0.553 -3.590 DEFB132 defensin, beta 132 20 186376 BE044548 20p13 Hs.516819 7

extracellular region

defense response to bacterium

 
210038_at PRKCQ protein kinase C, theta 10 -6509110 AL137145 10p15 Hs.498570 112

nucleotide binding

magnesium ion binding

regulation of cell growth

protein kinase C activity

protein binding

ATP binding

intracellular

protein amino acid phosphorylation

membrane protein ectodomain proteolysis

intracellular signaling cascade

zinc ion binding

transferase activity

diacylglycerol binding

Vascular smooth muscle contraction

Tight junction

T cell receptor signaling pathway

Adipocytokine signaling pathway

222400_s_at ADI1 acireductone dioxygenase 1 2 -3480696 BC001467 2p25.3 Hs.502773 13

protein binding

nucleus

cytoplasm

plasma membrane

cellular amino acid biosynthetic process

methionine biosynthetic process

nickel ion binding

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

methionine salvage

metal ion binding

oxidation reduction

Cysteine and methionine metabolism

Metabolic pathways

234871_at GPR98 G protein-coupled receptor 98 5 89890372 AL133041 5q13 Hs.591777 23

G-protein coupled receptor activity

calcium ion binding

cytoplasm

plasma membrane

neuropeptide signaling pathway

nervous system development

cell surface

integral to membrane

integral to membrane

cell-cell adhesion

photoreceptor cell maintenance

maintenance of organ identity

inner ear development

neurological system process

response to stimulus

detection of mechanical stimulus involved in sensory perception of sound

 
214476_at TFF2 trefoil factor 2 21 -42639537 NM_005423 21q22.3 Hs.2979 44

extracellular region

digestion

 
201289_at 1.679 6.609 2.590 2.032e-02 0.494 -3.155 CYR61 cysteine-rich, angiogenic inducer, 61 1 85819031 NM_001554 1p31-p22 Hs.8867 82

regulation of cell growth

patterning of blood vessels

insulin-like growth factor binding

extracellular region

chemotaxis

cell adhesion

heparin binding

cell proliferation

anatomical structure morphogenesis

positive regulation of cell-substrate adhesion

extracellular matrix organization

extracellular matrix binding

 
218252_at 0.522 5.045 2.347 3.288e-02 0.550 -3.558 CKAP2 cytoskeleton associated protein 2 13 51927495 NM_018204 13q14 Hs.444028 Hs.449585 Hs.711762 17

cytoplasm

cytoskeleton

microtubule

apoptosis

cell cycle

 
206304_at MYBPH myosin binding protein H 1 -201403561 NM_004997 1q32.1 Hs.927 6

protein binding

striated muscle thick filament

regulation of striated muscle contraction

cell adhesion

structural constituent of muscle

 
1554334_a_at DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 15 76343541, 76344043, 76345614 BC031044 15q25.1 Hs.513053 5

protein folding

zinc ion binding

membrane

heat shock protein binding

metal ion binding

unfolded protein binding

 
211609_x_at PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 1 149493820 U51007 1q21.3 Hs.505059 62

proteasome complex

protein binding

cytosol

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

203730_s_at 0.369 4.232 2.208 4.297e-02 0.576 -3.779 ZKSCAN5 zinc finger with KRAB and SCAN domains 5 7 98940208, 98940508 BF196931 7q22 Hs.110839 9

transcription factor activity

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
234971_x_at PLCD3 phospholipase C, delta 3 17 -40544533 AI521584 17q21.31 Hs.380094 20

angiogenesis

placenta development

phosphoinositide phospholipase C activity

signal transducer activity

calcium ion binding

cytoplasm

intracellular signaling cascade

membrane

lipid catabolic process

hydrolase activity

Inositol phosphate metabolism

Metabolic pathways

Calcium signaling pathway

Phosphatidylinositol signaling system

229222_at ACSS3 acyl-CoA synthetase short-chain family member 3 12 79995939 AI123815 12q21.31 Hs.259559 2

nucleotide binding

acetate-CoA ligase activity

ATP binding

mitochondrion

metabolic process

ligase activity

Propanoate metabolism

Metabolic pathways

222834_s_at 0.846 5.748 3.827 1.612e-03 0.259 -1.004 GNG12 guanine nucleotide binding protein (G protein), gamma 12 1 -67939736 N32508 1p31.3 Hs.431101 17

signal transducer activity

heterotrimeric G-protein complex

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

hormone-mediated signaling

MAPK signaling pathway

Chemokine signaling pathway

Regulation of actin cytoskeleton

213601_at SLIT1 slit homolog 1 (Drosophila) 10 -98747784 AB011537 10q23.3-q24 Hs.632082 16

calcium ion binding

protein binding

extracellular region

extracellular space

multicellular organismal development

nervous system development

brain development

cell differentiation

retinal ganglion cell axon guidance

establishment of nucleus localization

intracellular membrane-bounded organelle

Axon guidance

1554555_a_at SETD6 SET domain containing 6 16 57106883 BC022451 16q21 Hs.592060 5    
1561503_at -1.435 8.934 -3.335 4.448e-03 0.330 -1.867 MYLK4 myosin light chain kinase family, member 4 6 -2608861 AK096893 6p25.2 Hs.127830 4

nucleotide binding

protein serine/threonine kinase activity

ATP binding

protein amino acid phosphorylation

transferase activity

 
217115_at LOC100240726 makorin ring finger protein 1 pseudogene 20 -44525707 AL031686 20q13.12   1    
231128_at FAM181B family with sequence similarity 181, member B 11 -82120693 BE858471 11q14.1 Hs.448218 2    
216233_at CD163 CD163 molecule 12 -7514676 Z22970 12p13.3 Hs.504641 51

scavenger receptor activity

protein binding

extracellular region

plasma membrane

integral to plasma membrane

acute-phase response

inflammatory response

 
228469_at PPID peptidylprolyl isomerase D 4 -159849728 BF431902 4q31.3 Hs.581725 25

peptidyl-prolyl cis-trans isomerase activity

cytoplasm

protein folding

cyclosporin A binding

isomerase activity

heat shock protein binding

Calcium signaling pathway

Parkinson's disease

Huntington's disease

210495_x_at 1.039 8.987 3.984 1.168e-03 0.231 -0.732 FN1 fibronectin 1 2 -215987628, -215933423 AF130095 2q34 Hs.203717 291

extracellular matrix structural constituent

collagen binding

extracellular region

extracellular region

fibrinogen complex

proteinaceous extracellular matrix

ER-Golgi intermediate compartment

acute-phase response

cell adhesion

heparin binding

regulation of cell shape

response to wounding

cell migration

peptide cross-linking

platelet alpha granule lumen

substrate adhesion-dependent cell spreading

Focal adhesion

ECM-receptor interaction

Regulation of actin cytoskeleton

Pathways in cancer

Small cell lung cancer

202322_s_at 0.371 8.013 3.042 8.134e-03 0.387 -2.381 GGPS1 geranylgeranyl diphosphate synthase 1 1 233558375, 233558491 NM_004837 1q43 Hs.719270 13

dimethylallyltranstransferase activity

farnesyltranstransferase activity

geranyltranstransferase activity

soluble fraction

cytoplasm

isoprenoid biosynthetic process

transferase activity

Terpenoid backbone biosynthesis

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

236979_at BCL2L15 BCL2-like 15 1 -114220958 AI821801 1p13.2 Hs.123106 7

apoptosis

 
243821_at MRPS31 mitochondrial ribosomal protein S31 13 -40201431 AL120564 13q14.11 Hs.154655 8

mitochondrion

ribosome

protein domain specific binding

 
212508_at MOAP1 modulator of apoptosis 1 14 -92718293 AK024029 14q32 Hs.24719 15

protein binding

cytoplasm

activation of caspase activity

cell structure disassembly during apoptosis

apoptotic nuclear changes

protein homodimerization activity

 
227182_at SUSD3 sushi domain containing 3 9 94860809 AW966474 9q22.31 Hs.88417 4

membrane

integral to membrane

 
236859_at RUNX2 runt-related transcription factor 2 6 45404031, 45497891 AW469546 6p21 Hs.535845 152

osteoblast differentiation

transcription factor activity

RNA polymerase II transcription factor activity

protein binding

ATP binding

nucleus

regulation of transcription, DNA-dependent

negative regulation of transcription

transcription activator activity

 
223310_x_at PNPLA8 patatin-like phospholipase domain containing 8 7 -107899306 AF217519 7q31 Hs.617340 13

lysophospholipase activity

binding

ATP binding

intracellular

intracellular

membrane fraction

membrane fraction

cytoplasm

peroxisomal membrane

peroxisomal membrane

endoplasmic reticulum

Golgi apparatus

fatty acid metabolic process

fatty acid metabolic process

metabolic process

membrane

integral to membrane

lipid catabolic process

hydrolase activity

calcium-independent phospholipase A2 activity

calcium-independent phospholipase A2 activity

perinuclear region of cytoplasm

 
223330_s_at SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 13 52124831 BC000911 13q14.3 Hs.281902 13

ubiquitin ligase complex

kinetochore

binding

mitosis

modification-dependent protein catabolic process

 
1558698_at ZNF264 zinc finger protein 264 19 62394680 BF971035 19q13.4 Hs.515634 8

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
218973_at EFTUD1 elongation factor Tu GTP binding domain containing 1 15 -80209615 NM_024580 15q25.2 Hs.459114 4

nucleotide binding

translation elongation factor activity

GTPase activity

GTP binding

translation

 
204552_at INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 2 98427752, 98427752 AA355179 2q11.2 Hs.469386 16

signal transduction

phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity

hydrolase activity

phosphatidyl-inositol-4,5-bisphosphate 4-phosphatase activity

Inositol phosphate metabolism

Metabolic pathways

Phosphatidylinositol signaling system

217332_at RP11-159J2.1 CTAGE family, member 5 pseudogene 13 -74709889 AL133018 13q22.2 Hs.567920      
1553262_a_at -0.280 6.284 -2.800 1.332e-02 0.435 -2.799 UTS2R urotensin 2 receptor 17 77925489 NM_018949 17q25.3 Hs.192720 21

urotensin II receptor activity

receptor activity

G-protein coupled receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

blood circulation

integral to membrane

Neuroactive ligand-receptor interaction

214017_s_at DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 19 52544385 AA039439 19q13.3 Hs.151706 7

nucleotide binding

RNA binding

helicase activity

ATP binding

hydrolase activity

 
210426_x_at 0.721 5.791 3.034 8.267e-03 0.387 -2.395 RORA RAR-related orphan receptor A 15 -58567776, -58567776, -58567776 U04897 15q22.2 Hs.560343 Hs.655155 33

transcription factor activity

steroid hormone receptor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

nitric oxide biosynthetic process

signal transduction

zinc ion binding

cerebellar Purkinje cell differentiation

regulation of macrophage activation

sequence-specific DNA binding

positive regulation of transcription from RNA polymerase II promoter

cGMP metabolic process

metal ion binding

 
200769_s_at MAT2A methionine adenosyltransferase II, alpha 2 85619798 NM_005911 2p11.2 Hs.516157 18

nucleotide binding

magnesium ion binding

methionine adenosyltransferase activity

protein binding

ATP binding

S-adenosylmethionine biosynthetic process

one-carbon metabolic process

circadian rhythm

response to light stimulus

response to hormone stimulus

transferase activity

potassium ion binding

response to drug

cobalt ion binding

response to cAMP

Cysteine and methionine metabolism

Selenoamino acid metabolism

Biosynthesis of plant hormones

Metabolic pathways

1563478_at KIAA1671 KIAA1671 22 23753940 AL832019 22q11.23 Hs.419171 4    
227056_at 0.443 4.845 2.254 3.936e-02 0.567 -3.707 KIAA0141 KIAA0141 5 141283568 AA181172 5q31.3 Hs.210532 6

binding

mitochondrion

 
235766_x_at -0.506 4.068 -2.307 3.553e-02 0.556 -3.622 RAB27A RAB27A, member RAS oncogene family 15 -53283091, -53283091, -53283091, -53283091 AA743462 15q15-q21.1 Hs.654978 60

nucleotide binding

GTPase activity

protein binding

GTP binding

exocytosis

small GTPase mediated signal transduction

protein transport

membrane

dendrite

melanosome

exocytic vesicle

 
213842_x_at NSUN5C NOL1/NOP2/Sun domain family, member 5C 7 -72056767 AK021688 7q11.23 Hs.510927 5

methyltransferase activity

transferase activity

 
1553593_a_at TAL2 T-cell acute lymphocytic leukemia 2 9 107464558 NM_005421 9q32 Hs.247978 9

DNA binding

protein binding

nucleus

behavior

post-embryonic development

thalamus development

transcription regulator activity

midbrain development

multicellular organism growth

regulation of transcription

 
210499_s_at PQBP1 polyglutamine binding protein 1 X 48640138, 48640482 AB041834 Xp11.23 Hs.534384 26

DNA binding

transcription coactivator activity

protein binding

nucleus

nucleolus

cytoplasm

regulation of transcription, DNA-dependent

 
229209_at SNHG10 small nucleolar RNA host gene 10 (non-protein coding) 14 -95069001 AI302707 14q32.13 Hs.448753 3    
226049_at ERC1 ELKS/RAB6-interacting/CAST family member 1 12 970664 AI271420 12p13.3 Hs.655744 Hs.658200 19

protein binding

cytoplasm

Golgi apparatus

regulation of transcription, DNA-dependent

I-kappaB phosphorylation

multicellular organismal development

IkappaB kinase complex

protein transport

Rab GTPase binding

retrograde transport, endosome to Golgi

presynaptic membrane

leucine zipper domain binding

positive regulation of anti-apoptosis

positive regulation of NF-kappaB transcription factor activity

 
218744_s_at PACSIN3 protein kinase C and casein kinase substrate in neurons 3 11 -47155656 NM_016223 11p12-p11.12 Hs.334639 14

cytoplasm

plasma membrane

cytoskeletal protein binding

negative regulation of endocytosis

positive regulation of membrane protein ectodomain proteolysis

 
226210_s_at MEG3 maternally expressed 3 (non-protein coding) 14 100362197, 100362215 AI291123 14q32 Hs.525589 Hs.593706 Hs.654863 Hs.655127 11    
1556060_a_at ZNF451 zinc finger protein 451 6 57062786 AK027074 6p12.1-p11.2 Hs.485628 Hs.705485 13

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
226109_at C21orf91 chromosome 21 open reading frame 91 21 -18083154 AK023825 21q21.1 Hs.293811 8    
209659_s_at CDC16 cell division cycle 16 homolog (S. cerevisiae) 13 114018463 AF164598 13q34 Hs.374127 32

binding

nucleoplasm

cytoplasm

centrosome

cytosol

spindle microtubule

cell cycle

regulation of mitosis

cell proliferation

modification-dependent protein catabolic process

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

cell division

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Cell cycle

Ubiquitin mediated proteolysis

212264_s_at WAPAL wings apart-like homolog (Drosophila) 10 -88184992 BE645850 10q23.2 Hs.203099 Hs.714876 14

protein binding

nucleus

interspecies interaction between organisms

 
200922_at KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 19 -53577638 NM_006801 19q13.3 Hs.515515 14

receptor activity

KDEL sequence binding

protein binding

membrane fraction

endoplasmic reticulum

ER-Golgi intermediate compartment

protein retention in ER lumen

intracellular protein transport

membrane

integral to membrane

vesicle-mediated transport

Vibrio cholerae infection

212276_at LPIN1 lipin 1 2 11804190 D80010 2p25.1 Hs.467740 28

molecular_function

nucleus

lipid metabolic process

phosphatidate phosphatase activity

ruffle organization

actin cytoskeleton reorganization

cellular response to insulin stimulus

regulation of fat cell differentiation

 
211194_s_at TP63 tumor protein p63 3 190831909, 190831909, 190990142, 190990142 AB010153 3q28 Hs.137569 238

response to tumor cell

transcription factor activity

nucleus

nucleus

cytoplasm

apoptosis

induction of apoptosis

multicellular organismal development

zinc ion binding

transcription activator activity

transcription activator activity

transcription repressor activity

negative regulation of cell growth

identical protein binding

positive regulation of Notch signaling pathway

negative regulation of transcription, DNA-dependent

positive regulation of transcription, DNA-dependent

metal ion binding

protein homotetramerization

 
214869_x_at 0.285 6.059 2.940 1.001e-02 0.414 -2.557 GAPVD1 GTPase activating protein and VPS9 domains 1 9 127063931 AK021533 9q33.3 Hs.495134 9

guanyl-nucleotide exchange factor activity

GTPase activator activity

intracellular

endosome

cytosol

endocytosis

signal transduction

membrane

GTPase activating protein binding

regulation of small GTPase mediated signal transduction

regulation of protein transport

 
231973_s_at 0.566 4.745 2.320 3.463e-02 0.554 -3.601 ANAPC1 anaphase promoting complex subunit 1 2 -112243110 AK001223 2q12.1 Hs.436527 26

nucleoplasm

cytosol

cell cycle

mitosis

modification-dependent protein catabolic process

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

cell division

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Cell cycle

Ubiquitin mediated proteolysis

243564_at PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 7 -31795771 BE784669 7p14.3 Hs.655694 10

calmodulin-dependent cyclic-nucleotide phosphodiesterase activity

calmodulin binding

signal transduction

hydrolase activity

Purine metabolism

Calcium signaling pathway

Olfactory transduction

238111_at SDCCAG3 serologically defined colon cancer antigen 3 9 -138416194 AA829654 9q34.3 Hs.94300 7

cytoplasm

 
1558691_a_at -0.203 3.860 -2.139 4.904e-02 0.590 -3.888 DOCK4 dedicator of cytokinesis 4 7 -111153399 AV691156 7q31.1 Hs.654652 16

guanyl-nucleotide exchange factor activity

protein binding

membrane

SH3 domain binding

PDZ domain binding

Rac GTPase activator activity

stereocilium

Rac GTPase binding

 
232224_at MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 3 -188447299, -188434565, -188418631 AI274095 3q27-q28 Hs.89983 30

complement activation, lectin pathway

complement activation, lectin pathway

serine-type endopeptidase activity

calcium ion binding

extracellular region

extracellular region

extracellular space

proteolysis

peptidase activity

protein homodimerization activity

calcium-dependent protein binding

Complement and coagulation cascades

208209_s_at C4BPB complement component 4 binding protein, beta 1 205328834, 205329206, 205329250 NM_000716 1q32 Hs.99886 23

extracellular region

complement activation, classical pathway

blood coagulation

innate immune response

Complement and coagulation cascades

227681_at ZFP36L2 zinc finger protein 36, C3H type-like 2 2 -43303044 BF589368 2p22.3-p21 Hs.503093 8

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

transcription factor activity

RNA binding

nucleus

cytoplasm

zinc ion binding

cell proliferation

regulation of mRNA stability

metal ion binding

 
208993_s_at PPIG peptidylprolyl isomerase G (cyclophilin G) 2 170149095 AW340788 2q31.1 Hs.470544 10

peptidyl-prolyl cis-trans isomerase activity

nucleus

nucleoplasm

protein folding

RNA splicing

cyclosporin A binding

nuclear matrix

nuclear speck

isomerase activity

 
238149_at 0.431 2.307 2.625 1.895e-02 0.488 -3.097 ZNF818P zinc finger protein 818 pseudogene 19   AI651641 19q13.42 Hs.444446  

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
208186_s_at LIPE lipase, hormone-sensitive 19 -47597505 NM_005357 19q13.2 Hs.656980 74

triacylglycerol lipase activity

protein binding

cytoplasm

cytosol

plasma membrane

caveola

protein amino acid phosphorylation

metabolic process

steroid metabolic process

cholesterol metabolic process

lipid catabolic process

hydrolase activity

triglyceride catabolic process

hormone-sensitive lipase activity

diacylglycerol catabolic process

Insulin signaling pathway

244209_at LOC282992 hypothetical protein LOC282992 10   AI655594 10q24.31 Hs.386143 Hs.713042 1    
227195_at 0.819 5.934 3.405 3.847e-03 0.319 -1.744 ZNF503 zinc finger protein 503 10 -76827610 AA603467 10q22.2 Hs.195710 6

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
219067_s_at 0.246 6.848 2.347 3.289e-02 0.550 -3.558 NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 10 -123706592 NM_017615 10q26.13 Hs.258798 8    
1555694_a_at -0.296 5.706 -2.928 1.026e-02 0.417 -2.578 KCNIP3 Kv channel interacting protein 3, calsenilin 2 95326798, 95376494 AF367022 2q21.1 Hs.437376 43

negative regulation of transcription from RNA polymerase II promoter

DNA binding

transcription corepressor activity

voltage-gated ion channel activity

potassium channel activity

calcium ion binding

nucleus

cytoplasm

endoplasmic reticulum

Golgi apparatus

cytosol

plasma membrane

ion transport

potassium ion transport

apoptosis

signal transduction

behavior

protein C-terminus binding

specific transcriptional repressor activity

sensory perception of pain

potassium ion binding

regulation of neuron apoptosis

regulation of transcription

response to pain

calcium-dependent protein binding

 
232568_at MGC24103 hypothetical MGC24103 9   AU145658 9p22.3 Hs.664877 2    
214254_at MAGEA4 melanoma antigen family A, 4 X 150832016, 150835364, 150836052, 150837415 AW438674 Xq28 Hs.37107 24

molecular_function

protein binding

cellular_component

biological_process

 
230852_at STAC3 SH3 and cysteine rich domain 3 12 -55923508 AW663959 12q13.3 Hs.417595 4

intracellular signaling cascade

zinc ion binding

diacylglycerol binding

identical protein binding

metal ion binding

 
223248_at -0.464 6.573 -2.875 1.145e-02 0.426 -2.671 HSDL1 hydroxysteroid dehydrogenase like 1 16 -82713244 AK025626 16q23.3 Hs.555992 8

protein binding

metabolic process

oxidoreductase activity

 
219209_at IFIH1 interferon induced with helicase C domain 1 2 -162831834 NM_022168 2q24 Hs.163173 36

nucleotide binding

DNA binding

RNA binding

helicase activity

protein binding

ATP binding

intracellular

nucleus

cytoplasm

response to virus

hydrolase activity

regulation of apoptosis

interspecies interaction between organisms

innate immune response

RIG-I-like receptor signaling pathway

203795_s_at BCL7A B-cell CLL/lymphoma 7A 12 120944243 NM_020993 12q24.13 Hs.530970 9

molecular_function

cellular_component

negative regulation of transcription

 
227074_at LOC100131564 hypothetical protein LOC100131564 1   AA524669 1p22.1 Hs.648647      
1559206_at PSEN1 presenilin 1 14 72672895 BC002708 14q24.3 Hs.3260 386

kinetochore

endopeptidase activity

membrane fraction

integral to nuclear inner membrane

nuclear outer membrane

mitochondrion

endoplasmic reticulum

Golgi apparatus

integral to plasma membrane

membrane protein ectodomain proteolysis

apoptosis

anti-apoptosis

chromosome segregation

Notch receptor processing

intracellular signaling cascade

beta-catenin binding

cell death

peptidase activity

cell surface

membrane

cell-cell adhesion

protein processing

PDZ domain binding

endoplasmic reticulum calcium ion homeostasis

regulation of phosphorylation

amyloid precursor protein catabolic process

positive regulation of catalytic activity

Wnt signaling pathway

Notch signaling pathway

Neurotrophin signaling pathway

Alzheimer's disease

207186_s_at BPTF bromodomain PHD finger transcription factor 17 63252241 NM_004459 17q24.3 Hs.444200 22

negative regulation of transcription from RNA polymerase II promoter

nucleus

cytoplasm

chromatin remodeling

brain development

DNA-dependent ATPase activity

transcription factor binding

zinc ion binding

transcription regulator activity

positive regulation of gene-specific transcription

sequence-specific DNA binding

sequence-specific DNA binding

regulation of transcription

metal ion binding

 
209497_s_at -0.307 6.262 -2.153 4.774e-02 0.586 -3.866 RBM4B RNA binding motif protein 4B 11 -66189045 BC003503 11q13 Hs.618713 8

nucleotide binding

RNA binding

nucleus

nucleolus

mRNA processing

zinc ion binding

RNA splicing

metal ion binding

 
214002_at MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 12 54838366 AA419227 12q13.2 Hs.632717 12

motor activity

calcium ion binding

skeletal muscle tissue development

structural constituent of muscle

unconventional myosin complex

muscle filament sliding

actin-dependent ATPase activity

Vascular smooth muscle contraction

231885_at ZNF451 zinc finger protein 451 6 57062786 AB051489 6p12.1-p11.2 Hs.485628 Hs.705485 13

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
227566_at 0.240 3.580 2.436 2.759e-02 0.526 -3.412 NTM neurotrimin 11 130745580, 131285921, 131285921, 131285921 AW085558 11q25 Hs.504352 9

protein binding

plasma membrane

cell adhesion

neuron recognition

anchored to membrane

 
205005_s_at NMT2 N-myristoyltransferase 2 10 -15187776 AW293531 10p13 Hs.60339 35

glycylpeptide N-tetradecanoyltransferase activity

cytoplasm

Golgi apparatus

N-terminal protein myristoylation

acyltransferase activity

protein lipoylation

transferase activity

 
206356_s_at 0.636 5.119 2.904 1.077e-02 0.421 -2.619 GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18 11679135, 11741561 NM_002071 18p11.22-p11.21 Hs.136295 16

nucleotide binding

GTPase activity

signal transducer activity

GTP binding

signal transduction

G-protein coupled receptor protein signaling pathway

guanyl nucleotide binding

Calcium signaling pathway

Olfactory transduction

1566775_at DNAH1 dynein, axonemal, heavy chain 1 3 52325374 AK093347 3p21.1 Hs.655469 7

nucleotide binding

ciliary or flagellar motility

microtubule motor activity

ATP binding

axonemal dynein complex

microtubule

cilium

microtubule-based movement

ATPase activity

cilium axoneme

Huntington's disease

240033_at -0.411 6.080 -2.607 1.967e-02 0.491 -3.128 PLG plasminogen 6 161043263 BF447999 6q26 Hs.143436 198

serine-type endopeptidase activity

calcium ion binding

extracellular region

extracellular region

extracellular space

proteolysis

induction of apoptosis

blood coagulation

peptidase activity

negative regulation of cell proliferation

negative regulation of angiogenesis

apolipoprotein binding

negative regulation of blood vessel endothelial cell migration

tissue remodeling

negative regulation of fibrinolysis

positive regulation of fibrinolysis

Neuroactive ligand-receptor interaction

Complement and coagulation cascades

203020_at RABGAP1L RAB GTPase activating protein 1-like 1 172395256, 173111306 NM_014857 1q24 Hs.585378 9

GTPase activator activity

Rab GTPase activator activity

intracellular

regulation of Rab GTPase activity

 
214208_at KLHL35 kelch-like 35 (Drosophila) 11 -74811085 BF448703 11q13.4 Hs.292451 2    
226206_at MAFK v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) 7 1536893 BG231691 7p22.3 Hs.520612 14

transcription factor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

nervous system development

sequence-specific DNA binding

 
210762_s_at DLC1 deleted in liver cancer 1 8 -13116452, -12985242, -12985242 AF026219 8p22 Hs.134296 48

neural tube closure

heart morphogenesis

GTPase activator activity

protein binding

intracellular

nucleus

cytoplasm

caveola

focal adhesion

induction of apoptosis

activation of caspase activity

signal transduction

negative regulation of cell proliferation

negative regulation of cell proliferation

regulation of cell shape

hindbrain morphogenesis

negative regulation of cell migration

negative regulation of cell migration

Rac GTPase activator activity

forebrain development

regulation of actin cytoskeleton organization

negative regulation of Rho protein signal transduction

positive regulation of protein amino acid dephosphorylation

SH2 domain binding

focal adhesion formation

negative regulation of stress fiber formation

 
219977_at AIPL1 aryl hydrocarbon receptor interacting protein-like 1 17 -6267782 NM_014336 17p13.1 Hs.279887 18

farnesylated protein binding

binding

nucleus

cytoplasm

visual perception

protein farnesylation

response to stimulus

unfolded protein binding

 
202717_s_at CDC16 cell division cycle 16 homolog (S. cerevisiae) 13 114018463 NM_003903 13q34 Hs.374127 32

binding

nucleoplasm

cytoplasm

centrosome

cytosol

spindle microtubule

cell cycle

regulation of mitosis

cell proliferation

modification-dependent protein catabolic process

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

cell division

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Cell cycle

Ubiquitin mediated proteolysis

201994_at MORF4L2 mortality factor 4 like 2 X -102817083, -102817083 NM_012286 Xq22 Hs.326387 Hs.441076 Hs.597035 19

regulation of cell growth

molecular_function

protein binding

nucleus

nucleolus

DNA repair

response to DNA damage stimulus

chromatin modification

regulation of transcription

 
225211_at PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 11 -119050308, -119036912, -119014017 AW139723 11q23.3 Hs.334846 42

extracellular region

plasma membrane

cell-cell adherens junction

immune response

homophilic cell adhesion

heterophilic cell adhesion

coreceptor activity

integral to membrane

protein homodimerization activity

interspecies interaction between organisms

entry of virus into host cell

cell adhesion molecule binding

Cell adhesion molecules (CAMs)

Adherens junction

231157_at 0.357 5.922 2.214 4.247e-02 0.575 -3.770 TTLL11 tubulin tyrosine ligase-like family, member 11 9 -123791010, -123624025 BE856668 9q33.2 Hs.640663 Hs.644262 5

tubulin-tyrosine ligase activity

cilium

microtubule basal body

protein modification process

ligase activity

 
231539_at C3orf67 chromosome 3 open reading frame 67 3 -58702776 AW204126 3p14.2 Hs.368434 1    
1569194_at ZNF789 zinc finger protein 789 7 98908450, 98908450 AL708039 7q22.1 Hs.440384 4

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
1555505_a_at TYR tyrosinase (oculocutaneous albinism IA) 11 88550687 BC027179 11q14-q21 Hs.503555 121

monooxygenase activity

monophenol monooxygenase activity

copper ion binding

protein binding

cytoplasm

lysosome

Golgi-associated vesicle

melanin biosynthetic process from tyrosine

eye pigment biosynthetic process

visual perception

membrane

integral to membrane

melanosome

protein homodimerization activity

metal ion binding

protein heterodimerization activity

perinuclear region of cytoplasm

oxidation reduction

Tyrosine metabolism

Riboflavin metabolism

Isoquinoline alkaloid biosynthesis

Betalain biosynthesis

Biosynthesis of alkaloids derived from shikimate pathway

Metabolic pathways

Melanogenesis

235022_at C18orf19 chromosome 18 open reading frame 19 18 -13653345 BE326738 18p11.21 Hs.13034 3

membrane

integral to membrane

 
222879_s_at -0.254 4.820 -2.329 3.406e-02 0.553 -3.587 POLH polymerase (DNA directed), eta 6 43651855 AF158185 6p21.1 Hs.655467 65

magnesium ion binding

DNA synthesis during DNA repair

damaged DNA binding

DNA-directed DNA polymerase activity

nucleus

nucleoplasm

nucleolus

cytoplasm

regulation of DNA repair

pyrimidine dimer repair

postreplication repair

response to DNA damage stimulus

response to UV-C

transferase activity

nucleotidyltransferase activity

 
237407_at HS1BP3 HCLS1 binding protein 3 2 -20681044 BF197459 2p24.1 Hs.531785 7

protein binding

cell communication

phosphoinositide binding

 
210879_s_at 0.354 6.423 2.974 9.351e-03 0.401 -2.499 RAB11FIP5 RAB11 family interacting protein 5 (class I) 2 -73154017 AF334812 2p13-p12 Hs.24557 19

protein binding

cytoplasm

mitochondrion

mitochondrial outer membrane

endosome

biological_process

protein transport

membrane

gamma-tubulin binding

Endocytosis

1555595_at SCRN3 secernin 3 2 174968712 BC007344 2q31.1 Hs.470679 7    
1559481_at CHIC1 cysteine-rich hydrophobic domain 1 X 72699708 AL832095 Xq13-q21 Hs.496323 5

plasma membrane

cytoplasmic vesicle

 
1554531_at TTC12 tetratricopeptide repeat domain 12 11 112690460 BC032355 11q23.2 Hs.288772 11

binding

 
219952_s_at MCOLN1 mucolipin 1 19 7493511 NM_020533 19p13.3-p13.2 Hs.631858 37

cation channel activity

calcium ion binding

lysosome

endosome

plasma membrane

integral to plasma membrane

cation transport

calcium ion transport

 
232457_at LIMCH1 LIM and calponin homology domains 1 4 41057560, 41309675 AU147704 4p13 Hs.335163 10

actin binding

zinc ion binding

actomyosin structure organization

metal ion binding

 
218695_at 0.480 6.821 2.477 2.546e-02 0.516 -3.344 EXOSC4 exosome component 4 8 145205509 NM_019037 8q24.3 Hs.632041 16

3'-5'-exoribonuclease activity

exosome (RNase complex)

RNA binding

exonuclease activity

protein binding

nucleus

nucleolus

cytoplasm

rRNA processing

RNA processing

hydrolase activity

RNA degradation

1553561_at TAS2R50 taste receptor, type 2, member 50 12 -11029778 NM_176890 12p13.2 Hs.688194 13

receptor activity

G-protein coupled receptor activity

signal transduction

G-protein coupled receptor protein signaling pathway

membrane

integral to membrane

response to stimulus

sensory perception of taste

Taste transduction

241834_at IPW imprinted in Prader-Willi syndrome (non-protein coding) 15 22912784 AW299520 15q11-q12 Hs.555970 3    
209144_s_at CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 20 31541588, 31613831 AI810484 20q11 Hs.153934 19

transcription factor activity

transcription corepressor activity

protein binding

nucleus

zinc ion binding

epithelial cell differentiation

negative regulation of transcription, DNA-dependent

metal ion binding

 
235405_at GSTA4 glutathione S-transferase alpha 4 6 -52950705 N79662 6p12.1 Hs.485557 34

glutathione transferase activity

cytoplasm

metabolic process

transferase activity

Glutathione metabolism

Metabolism of xenobiotics by cytochrome P450

Drug metabolism - cytochrome P450

32091_at SLC25A44 solute carrier family 25, member 44 1 154430353 AB007915 1q22 Hs.532375 6

transporter activity

binding

mitochondrion

mitochondrial inner membrane

transport

membrane

integral to membrane

 
235855_at COX15 COX15 homolog, cytochrome c oxidase assembly protein (yeast) 10 -101458494 AA535888 10q24 Hs.28326 9

catalytic activity

cytochrome-c oxidase activity

mitochondrial respiratory chain

mitochondrial electron transport, cytochrome c to oxygen

protein complex assembly

heme a biosynthetic process

respiratory gaseous exchange

respiratory chain complex IV assembly

membrane

integral to membrane

mitochondrial part

cellular respiration

oxidation reduction

Oxidative phosphorylation

Porphyrin and chlorophyll metabolism

Metabolic pathways

232745_x_at SPEF2 sperm flagellar 2 5 35653745, 35653745 AK026817 5p13.2 Hs.298863 10

protein dimerization activity

 
226085_at CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila) 12 -52910996, -52910996, -52910996 AA181060 12q13.13 Hs.349283 65

kinetochore

chromatin

chromatin binding

nucleus

nuclear envelope

nucleolus

cytoplasm

chromatin assembly or disassembly

chromocenter

negative regulation of transcription

general transcriptional repressor activity

PML body

enzyme binding

nuclear centromeric heterochromatin

 
203614_at UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) 13 51496827 NM_021645 13q14.2 Hs.512963 7

nucleus

nucleolus

rRNA processing

meiosis

multicellular organismal development

spermatogenesis

cell differentiation

small-subunit processome

 
209941_at RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 6 3022056 U50062 6p25.2 Hs.519842 83

nucleotide binding

protein serine/threonine kinase activity

protein tyrosine kinase activity

death receptor binding

protein binding

ATP binding

cytoplasm

mitochondrion

cytosol

induction of apoptosis

signal transduction

activation of JUN kinase activity

activation of pro-apoptotic gene products

positive regulation of necrotic cell death

transferase activity

death-inducing signaling complex

tumor necrosis factor-mediated signaling pathway

response to tumor necrosis factor

positive regulation of I-kappaB kinase/NF-kappaB cascade

receptor complex

positive regulation of anti-apoptosis

protein amino acid autophosphorylation

positive regulation of NF-kappaB transcription factor activity

induction of necroptosis by extracellular signals

death domain binding

regulation of oxygen and reactive oxygen species metabolic process

Apoptosis

Toll-like receptor signaling pathway

RIG-I-like receptor signaling pathway

1564837_at LOC151760 hypothetical LOC151760 3   BC038577 3q13.13 Hs.124136 1    
221482_s_at ARPP19 cAMP-regulated phosphoprotein, 19kDa 15 -50626723 BC003418 15q21.2 Hs.512908 10

receptor binding

cytoplasm

potassium channel regulator activity

positive regulation of gluconeogenesis

positive regulation of glucose import

 
224570_s_at IRF2BP2 interferon regulatory factor 2 binding protein 2 1 -232806637 AA166696 1q42.3 Hs.693837 5

nucleus

regulation of transcription

 
236666_s_at LOC390205 leucine rich repeat containing 10-like 11 61032847 AA923289 11q12.2 Hs.441122 1

protein binding

 
1553534_at -0.221 4.010 -2.540 2.245e-02 0.500 -3.239 NLRP10 NLR family, pyrin domain containing 10 11 -7937731 NM_176821 11p15.4 Hs.449636 6

nucleotide binding

protein binding

ATP binding

 
210512_s_at -0.905 10.577 -2.271 3.811e-02 0.565 -3.680 VEGFA vascular endothelial growth factor A 6 43845930 AF022375 6p12 Hs.73793 1447

angiogenesis

vasculogenesis

response to hypoxia

positive regulation of endothelial cell proliferation

positive regulation of endothelial cell proliferation

fibronectin binding

positive regulation of leukocyte migration

cytokine activity

platelet-derived growth factor receptor binding

extracellular region

extracellular region

proteinaceous extracellular matrix

extracellular space

multicellular organismal development

nervous system development

growth factor activity

heparin binding

regulation of cell shape

cell surface

membrane

positive regulation of vascular endothelial growth factor receptor signaling pathway

platelet alpha granule lumen

protein homodimerization activity

negative regulation of apoptosis

vascular endothelial growth factor receptor 1 binding

vascular endothelial growth factor receptor 2 binding

cell surface binding

positive regulation of blood vessel endothelial cell migration

platelet-derived growth factor receptor signaling pathway

extracellular matrix binding

induction of positive chemotaxis

Cytokine-cytokine receptor interaction

mTOR signaling pathway

VEGF signaling pathway

Focal adhesion

Pathways in cancer

Renal cell carcinoma

Pancreatic cancer

Bladder cancer

201876_at 0.456 7.307 2.168 4.637e-02 0.582 -3.842 PON2 paraoxonase 2 7 -94872109 NM_000305 7q21.3 Hs.719159 112

aryldialkylphosphatase activity

arylesterase activity

extracellular region

plasma membrane

hydrolase activity

aromatic compound catabolic process

identical protein binding

gamma-Hexachlorocyclohexane degradation

Bisphenol A degradation

Metabolic pathways

209653_at KPNA4 karyopherin alpha 4 (importin alpha 3) 3 -161700655 U93240 3q25.33 Hs.715552 53

protein binding

nucleus

nuclear pore

cytoplasm

NLS-bearing substrate import into nucleus

intracellular protein transport

protein transporter activity

 
205459_s_at NPAS2 neuronal PAS domain protein 2 2 100803044 NM_002518 2q11.2 Hs.156832 Hs.705895 23

transcription factor activity

signal transducer activity

nucleus

transcription factor complex

regulation of transcription, DNA-dependent

signal transduction

central nervous system development

circadian sleep/wake cycle

locomotor rhythm

positive regulation of transcription from RNA polymerase II promoter

rhythmic process

Hsp90 protein binding

Circadian rhythm - mammal

230115_at 0.348 6.442 2.298 3.613e-02 0.558 -3.636 DKFZp779M0652 hypothetical DKFZp779M0652 11 45749558 BE348376 11p11.2 Hs.632142 1    
212007_at 0.433 7.848 2.733 1.526e-02 0.457 -2.914 UBXN4 UBX domain protein 4 2 136215658 AI927512 2q21.3 Hs.591242 12

protein binding

nucleus

nuclear envelope

endoplasmic reticulum

response to unfolded protein

membrane

integral to membrane

 
218689_at FANCF Fanconi anemia, complementation group F 11 -22600654 NM_022725 11p15 Hs.713574 27

molecular_function

protein binding

cellular_component

nucleus

DNA repair

response to DNA damage stimulus

biological_process

 
1553314_a_at KIF19 kinesin family member 19 17 69833945 NM_153209 17q25.1 Hs.372773 6

nucleotide binding

microtubule motor activity

ATP binding

microtubule

microtubule-based movement

 
220536_at C14orf115 chromosome 14 open reading frame 115 14 73884918 NM_018228 14q24.3 Hs.578167 4

DNA binding

transposase activity

transposition, DNA-mediated

 
205953_at LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 1 113417353 NM_014813 1p13.1 Hs.448972 Hs.696605 7

protein binding

cytoplasm

plasma membrane

integral to membrane

 
207862_at UPK2 uroplakin 2 11 118332235 NM_006760 11q23 Hs.710330 14

plasma membrane

integral to plasma membrane

multicellular organismal development

membrane organization

integral to endoplasmic reticulum membrane

epithelial cell differentiation

 
231509_at -0.263 4.313 -2.257 3.911e-02 0.567 -3.702 C7orf16 chromosome 7 open reading frame 16 7 31693323 AW614524 7p15 Hs.227011 8

protein serine/threonine phosphatase inhibitor activity

soluble fraction

protein amino acid phosphorylation

signal transduction

protein kinase cascade

central nervous system development

behavior

Long-term depression

1562738_a_at 0.264 2.781 2.397 2.978e-02 0.536 -3.475 LOC100130855 hypothetical protein LOC100130855 15   AK093077 15q22.31 Hs.667198 2    
225630_at EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 7 36159360 AB051493 7p14.2 Hs.487994 Hs.670591 4

DNA binding

intracellular

DNA repair

 
210939_s_at GRM1 glutamate receptor, metabotropic 1 6 146390474 L76631 6q24 Hs.32945 51

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

synaptic transmission

glutamate receptor activity

Calcium signaling pathway

Neuroactive ligand-receptor interaction

Gap junction

Long-term potentiation

Long-term depression

232625_at TLN2 talin 2 15 60726801 AA719572 15q15-q21 Hs.569438 Hs.610975 17

ruffle

actin binding

structural constituent of cytoskeleton

protein binding

cytoplasm

plasma membrane

cell-cell junction

focal adhesion

cytoskeletal anchoring at plasma membrane

cell-cell junction assembly

cell adhesion

actin cytoskeleton

synapse

Focal adhesion

238947_at MFSD3 major facilitator superfamily domain containing 3 8 145705359 BE048524 8q24.3 Hs.7678 3

transport

membrane

integral to membrane

 
222223_s_at IL1F5 interleukin 1 family, member 5 (delta) 2 113532685, 113533155 AF216693 2q14 Hs.516301 28

cytokine activity

interleukin-1 receptor antagonist activity

extracellular region

extracellular space

immune response

 
1553959_a_at B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 1 1157491 N95564 1p36.33 Hs.284284 4

Golgi apparatus

Golgi medial cisterna

glycosaminoglycan biosynthetic process

protein amino acid glycosylation

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

membrane

integral to membrane

transferase activity, transferring glycosyl groups

manganese ion binding

galactosylxylosylprotein 3-beta-galactosyltransferase activity

Chondroitin sulfate biosynthesis

Heparan sulfate biosynthesis

Metabolic pathways

202056_at KPNA1 karyopherin alpha 1 (importin alpha 5) 3 -123623437 AW051311 3q21 Hs.161008 92

regulation of DNA recombination

protein binding

nucleus

nuclear pore

nucleoplasm

cytoplasm

cytosol

NLS-bearing substrate import into nucleus

intracellular protein transport

nuclear localization sequence binding

protein transporter activity

interspecies interaction between organisms

 
238689_at GPR110 G protein-coupled receptor 110 6 -47095580, -47075771 BG426455 6p12.3 Hs.256897 11

G-protein coupled receptor activity

G-protein coupled receptor activity

plasma membrane

neuropeptide signaling pathway

integral to membrane

integral to membrane

 
217074_at SMOX spermine oxidase 20 4077449 AK025938 20p13 Hs.433337 17

cytoplasm

electron carrier activity

oxidoreductase activity

spermine catabolic process

polyamine oxidase activity

oxidation reduction

 
1555450_a_at NARG1L NMDA receptor regulated 1-like 13 40783340, 40783340, 40783417 BC032318 13q14.11 Hs.512914 8

protein binding

nucleus

transcription factor complex

cytoplasm

N-terminal protein amino acid acetylation

acetyltransferase activity

ribosome binding

positive regulation of transcription, DNA-dependent

 
203055_s_at ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 19 47079106, 47080285 NM_004706 19q13.13 Hs.631550 29

guanyl-nucleotide exchange factor activity

Rho guanyl-nucleotide exchange factor activity

GTPase activator activity

protein binding

intracellular

cytoplasm

cytosol

plasma membrane

plasma membrane

cell proliferation

regulation of Rho protein signal transduction

Vascular smooth muscle contraction

Regulation of actin cytoskeleton

229748_x_at LOC100132288 hypothetical protein LOC100132288 21 -103279, -493625 AI380156 21p11.2 Hs.487562 7    
214743_at CUX1 cut-like homeobox 1 7 101246011, 101246022, 101247601 BE046521 7q22.1 Hs.654389 53

negative regulation of transcription from RNA polymerase II promoter

negative regulation of transcription from RNA polymerase II promoter

DNA binding

chromatin binding

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

Golgi apparatus

transport

intra-Golgi vesicle-mediated transport

multicellular organismal development

membrane

integral to membrane

transcription repressor activity

integral to Golgi membrane

lung development

auditory receptor cell differentiation

sequence-specific DNA binding

 
1554253_a_at LASS3 LAG1 homolog, ceramide synthase 3 15 -98758122 BC028703 15q26.3 Hs.662371 3

transcription factor activity

nucleus

cytoplasm

regulation of transcription, DNA-dependent

lipid biosynthetic process

membrane

integral to membrane

sphingolipid biosynthetic process

sequence-specific DNA binding

sphingosine N-acyltransferase activity

 
220485_s_at SIRPG signal-regulatory protein gamma 20 -1557797 NM_018556 20p13 Hs.590883 11

protein binding

plasma membrane

cell adhesion

intracellular signaling cascade

cell-cell signaling

positive regulation of cell proliferation

negative regulation of cell proliferation

integral to membrane

positive regulation of cell-cell adhesion

positive regulation of T cell activation

 
237894_at C3orf22 chromosome 3 open reading frame 22 3 -127751208 AA437300 3q21.3 Hs.178210 3    
235848_x_at ATL2 atlastin GTPase 2 2 -38375534 N35250 2p22.2-p22.1 Hs.594950 8

nucleotide binding

GTPase activity

GTP binding

membrane

integral to membrane

 
1556351_at HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1 5 -45295108 BM682352 5p12 Hs.650434 17

nucleotide binding

voltage-gated ion channel activity

voltage-gated potassium channel activity

sodium channel activity

protein binding

ion transport

potassium ion transport

sodium ion transport

membrane

integral to membrane

axon

dendrite

cAMP binding

potassium ion binding

sodium ion binding

apical protein localization

 
209650_s_at TBC1D22A TBC1 domain family, member 22A 22 45537212 BC001292 22q13.3 Hs.435044 9

GTPase activator activity

Rab GTPase activator activity

intracellular

regulation of Rab GTPase activity

 
221531_at WDR61 WD repeat domain 61 15 -76362632 AF309553 15q25.1 Hs.513055 6  

RNA degradation

208473_s_at -0.368 4.033 -2.301 3.591e-02 0.557 -3.631 GP2 glycoprotein 2 (zymogen granule membrane) 16 -20229311 NM_016295 16p12 Hs.53985 16

extracellular region

cytoplasm

plasma membrane

anchored to membrane

 
212468_at SPAG9 sperm associated antigen 9 17 -46394534 AK023512 17q21.33 Hs.463439 22

acrosomal vesicle

protein binding

cytoplasm

spermatogenesis

integral to membrane

positive regulation of cell migration

perinuclear region of cytoplasm

 
200736_s_at GPX1 glutathione peroxidase 1 3 -49369612 NM_000581 3p21.3 Hs.76686 126

temperature homeostasis

release of cytochrome c from mitochondria

endothelial cell development

negative regulation of inflammatory response to antigenic stimulus

glutathione peroxidase activity

glutathione peroxidase activity

cytoplasm

mitochondrion

cytosol

lipid metabolic process

triglyceride metabolic process

glutathione metabolic process

anti-apoptosis

induction of apoptosis

sensory perception of sound

selenium binding

proteasome inhibitor activity

induction of apoptosis by oxidative stress

response to xenobiotic stimulus

response to symbiotic bacterium

response to wounding

response to toxin

UV protection

response to selenium ion

response to gamma radiation

myotube differentiation

oxidoreductase activity

SH3 domain binding

protein amino acid oxidation

response to hydroperoxide

regulation of mammary gland epithelial cell proliferation

regulation of gene expression, epigenetic

vasodilation

response to hydrogen peroxide

hydrogen peroxide catabolic process

negative regulation of caspase activity

glutathione binding

skeletal muscle regeneration

regulation of neuron apoptosis

blood vessel endothelial cell migration

fat cell differentiation

myoblast proliferation

interaction with symbiont

positive regulation of protein kinase B signaling cascade

oxidation reduction

heart contraction

angiogenesis involved in wound healing

Glutathione metabolism

Arachidonic acid metabolism

Amyotrophic lateral sclerosis (ALS)

Huntington's disease

202042_at HARS histidyl-tRNA synthetase 5 -140033673 NM_002109 5q31.3 Hs.528050 20

nucleotide binding

histidine-tRNA ligase activity

ATP binding

cytoplasm

histidyl-tRNA aminoacylation

ligase activity

Aminoacyl-tRNA biosynthesis

203833_s_at -0.337 5.474 -2.658 1.773e-02 0.473 -3.040 TGOLN2 trans-golgi network protein 2 2 -85398656 BF061845 2p11.2 Hs.593382 14

protein binding

nucleus

nucleolus

cytoplasm

Golgi apparatus

trans-Golgi network

plasma membrane

integral to membrane

transport vesicle

 
210165_at DNASE1 deoxyribonuclease I 16 3642940 M55983 16p13.3 Hs.629638 48

actin binding

endonuclease activity

deoxyribonuclease I activity

deoxyribonuclease activity

calcium ion binding

protein binding

extracellular region

nucleus

nuclear envelope

DNA catabolic process

apoptosis

hydrolase activity

 
215034_s_at 0.505 6.910 3.520 3.038e-03 0.300 -1.542 TM4SF1 transmembrane 4 L six family member 1 3 -150569494 AI189753 3q21-q25 Hs.715499 16

molecular_function

integral to plasma membrane

biological_process

membrane

 
1558306_at -0.327 3.086 -3.346 4.349e-03 0.328 -1.848 THADA thyroid adenoma associated 2 -43311478, -43311478 AL832141 2p21 Hs.369592 17

binding

 
1552256_a_at SCARB1 scavenger receptor class B, member 1 12 -123828126 NM_005505 12q24.31 Hs.709216 127

phosphatidylserine binding

lipopolysaccharide receptor activity

receptor activity

transporter activity

phosphatidylinositol binding

plasma membrane

caveola

cell adhesion

positive regulation of endothelial cell migration

positive regulation of cholesterol storage

lipopolysaccharide transport

integral to membrane

low-density lipoprotein binding

detection of lipopolysaccharide

cholesterol efflux

apolipoprotein A-I binding

high-density lipoprotein particle remodeling

high-density lipoprotein particle clearance

wound healing

cholesterol homeostasis

recognition of apoptotic cell

reverse cholesterol transport

interspecies interaction between organisms

regulation of phagocytosis

positive regulation of nitric-oxide synthase activity

adhesion to symbiont

triglyceride homeostasis

high-density lipoprotein receptor activity

cholesterol import

 
207311_at DOC2B double C2-like domains, beta 17 633000 NM_003585 17p13.3 Hs.648240 8

transporter activity

calcium ion binding

calcium-dependent phospholipid binding

transport

synaptic vesicle

membrane

 
206724_at CBX4 chromobox homolog 4 (Pc class homolog, Drosophila) 17 -75421549 NM_003655 17q25.3 Hs.714363 25

chromatin

chromatin binding

transcription corepressor activity

nucleus

chromatin assembly or disassembly

anti-apoptosis

negative regulation of transcription

chromatin modification

enzyme binding

modification-dependent protein catabolic process

 
218078_s_at ZDHHC3 zinc finger, DHHC-type containing 3 3 -44931757 NM_016598 3p21.31 Hs.61430 8

Golgi apparatus

zinc ion binding

acyltransferase activity

membrane

integral to membrane

transferase activity

metal ion binding

 
212639_x_at 0.644 10.322 2.677 1.707e-02 0.470 -3.008 TUBA1B tubulin, alpha 1b 12 -47807832 AL581768 12q13.12 Hs.524390 Hs.719075 42

nucleotide binding

microtubule cytoskeleton organization

GTPase activity

structural constituent of cytoskeleton

protein binding

GTP binding

microtubule

microtubule-based movement

protein complex

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

210094_s_at PARD3 par-3 partitioning defective 3 homolog (C. elegans) 10 -34440102 AF196186 10p11.21 Hs.131489 40

protein binding

cytoplasm

plasma membrane

tight junction

tight junction

cell cortex

protein complex assembly

cell cycle

establishment or maintenance of cell polarity

activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway

axonogenesis

asymmetric cell division

cell junction

Chemokine signaling pathway

Neuroactive ligand-receptor interaction

Endocytosis

Adherens junction

Tight junction

204157_s_at QSK serine/threonine-protein kinase QSK 11 -116219327 NM_025164 11q23.3 Hs.167451 14

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

protein amino acid phosphorylation

transferase activity

 
207494_s_at ZNF76 zinc finger protein 76 (expressed in testis) 6 35335487 NM_003427 6p21.3-p21.2 Hs.388024 9

DNA binding

intracellular

nucleus

regulation of transcription from RNA polymerase II promoter

regulation of transcription from RNA polymerase III promoter

zinc ion binding

regulation of transcription

metal ion binding

 
206080_at PLCH2 phospholipase C, eta 2 1 2397613 NM_014638 1p36.32 Hs.170156 7

molecular_function

phosphoinositide phospholipase C activity

signal transducer activity

calcium ion binding

cellular_component

cytoplasm

plasma membrane

intracellular signaling cascade

biological_process

lipid catabolic process

hydrolase activity

 
240444_x_at CLIP1 CAP-GLY domain containing linker protein 1 12 -121321933 AA868722 12q24.3 Hs.524809 37

kinetochore

nucleic acid binding

protein binding

cytoplasm

endosome

microtubule

intermediate filament

mitosis

microtubule binding

zinc ion binding

protein homodimerization activity

metal ion binding

 
209199_s_at MEF2C myocyte enhancer factor 2C 5 -88049814, -88049814 N22468 5q14 Hs.653394 56

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

regulation of transcription, DNA-dependent

apoptosis

multicellular organismal development

nervous system development

muscle organ development

negative regulation of specific transcription from RNA polymerase II promoter

nuclear speck

cell differentiation

sequence-specific DNA binding

positive regulation of survival gene product expression

MAPK signaling pathway

222558_at RPRD1A regulation of nuclear pre-mRNA domain containing 1A 18 -31823789 T79568 18q12.2 Hs.464912 3    
217940_s_at 0.477 7.691 3.583 2.664e-03 0.290 -1.431 CARKD carbohydrate kinase domain containing 13 110066008 NM_018210 13q34 Hs.408324 5

molecular_function

cellular_component

biological_process

 
202743_at -0.730 6.644 -2.779 1.389e-02 0.442 -2.835 PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 1 -46278398, -46278398 BE622627 1p34.1 Hs.655387 16

protein binding

phosphoinositide 3-kinase complex

insulin receptor signaling pathway

1-phosphatidylinositol-3-kinase activity

1-phosphatidylinositol-3-kinase regulator activity

ErbB signaling pathway

Chemokine signaling pathway

Phosphatidylinositol signaling system

mTOR signaling pathway

Apoptosis

VEGF signaling pathway

Focal adhesion

Toll-like receptor signaling pathway

Jak-STAT signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Fc gamma R-mediated phagocytosis

Leukocyte transendothelial migration

Neurotrophin signaling pathway

Regulation of actin cytoskeleton

Insulin signaling pathway

Type II diabetes mellitus

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Endometrial cancer

Glioma

Prostate cancer

Melanoma

Chronic myeloid leukemia

Acute myeloid leukemia

Small cell lung cancer

Non-small cell lung cancer

236098_at hCG_1643808 hypothetical protein LOC100130933 17 71154240 AA429598   Hs.662541 2    
233496_s_at CFL2 cofilin 2 (muscle) 14 -34249338, -34249338, -34249338 AV726166 14q12 Hs.180141 20

actin binding

protein binding

intracellular

nucleus

cytoplasm

cytoskeleton

nuclear matrix

Axon guidance

Fc gamma R-mediated phagocytosis

Regulation of actin cytoskeleton

230380_at 0.515 4.434 2.721 1.561e-02 0.459 -2.933 THAP2 THAP domain containing, apoptosis associated protein 2 12 70344050 AW235671 12q21.1 Hs.245798 8

DNA binding

nucleolus

zinc ion binding

metal ion binding

 
1554564_a_at UNQ1887 signal peptide peptidase 3 12 -119685417 BC011943 12q24.31 Hs.507087 Hs.683964 12

aspartic-type endopeptidase activity

peptidase activity

membrane

integral to membrane

 
204652_s_at NRF1 nuclear respiratory factor 1 7 129038790, 129057154 NM_005011 7q32 Hs.654363 47

DNA binding

nucleus

generation of precursor metabolites and energy

regulation of transcription from RNA polymerase II promoter

regulation of transcription

Huntington's disease

229203_at B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 12 439803 AI695127 12p13.33 Hs.504416 6

Golgi apparatus

membrane

integral to membrane

transferase activity

Golgi cisterna membrane

N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity

 
1553219_a_at -0.262 3.713 -2.323 3.443e-02 0.553 -3.596 AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 X -109324069 NM_015365 Xq22.3 Hs.656243 7

molecular_function

cellular_component

biological_process

 
35147_at MCF2L MCF.2 cell line derived transforming sequence-like 13 112670757, 112681655 AB002360 13q34 Hs.170422 Hs.597691 15

guanyl-nucleotide exchange factor activity

Rho guanyl-nucleotide exchange factor activity

intracellular

cytoplasm

mitochondrion

plasma membrane

intracellular signaling cascade

regulation of Rho protein signal transduction

 
238989_at C1GALT1C1 C1GALT1-specific chaperone 1 X -119643561 BF749723 Xq24 Hs.643920 13

membrane

integral to membrane

O-Glycan biosynthesis

Metabolic pathways

228082_at ASAM adipocyte-specific adhesion molecule 11 -122448242 BF056275 11q24.1 Hs.591949 Hs.665354 8

nucleus

cytoplasm

plasma membrane

tight junction

integral to membrane

cell junction

 
221951_at 0.503 7.360 3.026 8.395e-03 0.388 -2.407 TMEM80 transmembrane protein 80 11 685615 AI739035 11p15.5 Hs.448664 2

membrane

integral to membrane

 
1564241_at ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 1 158387975, 158413824 AK098076 1q21-q23 Hs.662219 18

nucleotide binding

magnesium ion binding

sodium:potassium-exchanging ATPase activity

ATP binding

sodium:potassium-exchanging ATPase complex

ATP biosynthetic process

potassium ion transport

sodium ion transport

metabolic process

monovalent inorganic cation transmembrane transporter activity

ATP hydrolysis coupled proton transport

membrane

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

sperm motility

regulation of cellular pH

potassium ion binding

sodium ion binding

Cardiac muscle contraction

1557866_at -0.265 4.542 -2.731 1.532e-02 0.457 -2.917 C9orf117 chromosome 9 open reading frame 117 9 129509091 AK094948 9q34.11 Hs.652519 2    
234633_at -0.338 3.013 -2.925 1.032e-02 0.418 -2.583 KRTAP4-11 keratin associated protein 4-11 17 -36526961, 234615 AJ406944 17q21.2 Hs.307015 Hs.719695 Hs.719855 5

keratin filament

 
201402_at ADRBK1 adrenergic, beta, receptor kinase 1 11 66790480 NM_001619 11q13.1 Hs.83636 98

nucleotide binding

regulation of the force of heart contraction

desensitization of G-protein coupled receptor protein signaling pathway

negative regulation of the force of heart contraction by chemical signal

G-protein coupled receptor kinase activity

signal transducer activity

protein binding

ATP binding

soluble fraction

cytoplasm

signal transduction

muscarinic acetylcholine receptor signaling pathway

tachykinin receptor signaling pathway

heart development

membrane

transferase activity

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

positive regulation of catecholamine secretion

negative regulation of striated muscle contraction

beta-adrenergic receptor kinase activity

cardiac muscle contraction

Chemokine signaling pathway

Endocytosis

218786_at NT5DC3 5'-nucleotidase domain containing 3 12 -102690210 NM_016575 12q22-q23.1 Hs.48428 4

magnesium ion binding

hydrolase activity

 
221547_at PRPF18 PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae) 10 13668944 BC000794 10p13 Hs.161181 6

nucleus

spliceosomal complex

mRNA processing

RNA splicing

nuclear speck

 
1555970_at FBXO28 F-box protein 28 1 222368413 AU154086 1q42.11 Hs.64691 Hs.713992 10

modification-dependent protein catabolic process

 
200750_s_at 0.485 9.329 2.420 2.848e-02 0.532 -3.438 RAN RAN, member RAS oncogene family 12 129922569 AF054183 12q24.3 Hs.10842 132

nucleotide binding

chromatin

chromatin binding

transcription coactivator activity

GTPase activity

GTPase activity

protein binding

GTP binding

nucleus

nuclear pore

nucleoplasm

cytoplasm

cytosol

DNA metabolic process

RNA export from nucleus

protein export from nucleus

intracellular protein transport

nucleocytoplasmic transport

mitotic spindle organization

mitosis

signal transduction

androgen receptor signaling pathway

melanosome

interspecies interaction between organisms

positive regulation of transcription, DNA-dependent

androgen receptor binding

 
207446_at TLR6 toll-like receptor 6 4 -38504802 NM_006068 4p14 Hs.654532 Hs.662185 59

transmembrane receptor activity

plasma membrane

plasma membrane

integral to plasma membrane

inflammatory response

signal transduction

activation of NF-kappaB-inducing kinase activity

lipoprotein binding

cytoplasmic vesicle

T-helper 1 type immune response

defense response to bacterium

positive regulation of I-kappaB kinase/NF-kappaB cascade

positive regulation of JUN kinase activity

innate immune response

positive regulation of interleukin-6 biosynthetic process

Toll-like receptor signaling pathway

208873_s_at REEP5 receptor accessory protein 5 5 -112239979 BC000232 5q22-q23 Hs.429608 11

molecular_function

protein binding

biological_process

membrane

integral to membrane

 
218563_at NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 19 59297971 NM_004542 19q13.42 Hs.198269 7

mitochondrion

mitochondrial inner membrane

mitochondrial respiratory chain complex I

mitochondrial electron transport, NADH to ubiquinone

transport

NADH dehydrogenase (ubiquinone) activity

membrane

integral to membrane

electron transport chain

respiratory chain

Oxidative phosphorylation

Metabolic pathways

Alzheimer's disease

Parkinson's disease

Huntington's disease

206067_s_at WT1 Wilms tumor 1 11 -32365900 NM_024426 11p13 Hs.591980 228

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
219646_at 0.620 6.572 3.109 7.091e-03 0.372 -2.264 DEF8 differentially expressed in FDCP 8 homolog (mouse) 16 88542651, 88542683 NM_017702 16q24.3 Hs.62771 4

protein binding

intracellular signaling cascade

zinc ion binding

diacylglycerol binding

metal ion binding

 
215026_x_at SCNN1A sodium channel, nonvoltage-gated 1 alpha 12 -6326271, -6326271, -6326271 U81961 12p13 Hs.591047 80

actin binding

ion channel activity

protein binding

membrane fraction

plasma membrane

ion transport

sodium ion transport

excretion

external side of plasma membrane

amiloride-sensitive sodium channel activity

integral to membrane

apical plasma membrane

cortical actin cytoskeleton

sodium ion binding

sodium channel complex

WW domain binding

response to stimulus

sensory perception of taste

Taste transduction

238698_at CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) X -41259132 AI659225 Xp11.4 Hs.495984 54

nucleotide binding

guanylate kinase activity

protein serine/threonine kinase activity

calmodulin binding

ATP binding

nucleus

cytoplasm

plasma membrane

protein amino acid phosphorylation

cell adhesion

actin cytoskeleton

transferase activity

Tight junction

229650_s_at 0.326 6.526 3.416 3.761e-03 0.317 -1.724 C19orf42 chromosome 19 open reading frame 42 19 -16617958 BG538931 19p13.11 Hs.356467 1

membrane

integral to membrane

 
203628_at IGF1R insulin-like growth factor 1 receptor 15 97010283 H05812 15q26.3 Hs.643120 Hs.653608 Hs.714012 315

nucleotide binding

receptor activity

insulin-like growth factor receptor activity

insulin receptor binding

ATP binding

microsome

integral to plasma membrane

anti-apoptosis

immune response

signal transduction

brain development

positive regulation of cell proliferation

insulin receptor signaling pathway

organ morphogenesis

phosphoinositide 3-kinase cascade

membrane

transferase activity

male sex determination

positive regulation of cell migration

mammary gland development

insulin-like growth factor I binding

identical protein binding

phosphoinositide 3-kinase binding

insulin binding

insulin receptor substrate binding

positive regulation of DNA replication

protein amino acid autophosphorylation

insulin-like growth factor receptor signaling pathway

phosphoinositide-mediated signaling

protein tetramerization

Endocytosis

Focal adhesion

Adherens junction

Long-term depression

Pathways in cancer

Colorectal cancer

Glioma

Prostate cancer

Melanoma

218085_at CHMP5 chromatin modifying protein 5 9 33254876 NM_015961 9p13.3 Hs.635313 14

regulation of receptor recycling

protein binding

nucleus

cytoplasm

endosome

cytosol

lysosome organization

endosome to lysosome transport

protein transport

membrane

Endocytosis

213009_s_at TRIM37 tripartite motif-containing 37 17 -54430342, -54414781 AK022701 17q23.2 Hs.579079 Hs.605697 23

protein binding

intracellular

cytoplasm

peroxisome

zinc ion binding

metal ion binding

Ubiquitin mediated proteolysis

1569121_at -0.330 5.161 -2.664 1.752e-02 0.473 -3.031 SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 1 -108478969, -108478969 BC029905 1p13.3 Hs.656870 4

binding

calcium ion binding

mitochondrion

mitochondrial inner membrane

transport

membrane

integral to membrane

 
222853_at FLRT3 fibronectin leucine rich transmembrane protein 3 20 -14252642, -14252642 N71923 20p11 Hs.41296 9

receptor signaling protein activity

proteinaceous extracellular matrix

integral to plasma membrane

cell adhesion

biological_process

membrane

protein binding, bridging

 
206562_s_at 0.706 6.685 3.218 5.665e-03 0.356 -2.073 CSNK1A1 casein kinase 1, alpha 1 5 -148855037 NM_001892 5q32 Hs.529862 Hs.712555 53

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

cytosol

protein amino acid phosphorylation

Wnt receptor signaling pathway

transferase activity

Wnt signaling pathway

Hedgehog signaling pathway

220747_at HSPC072 hypothetical LOC29075 20 -18716614, -18716614 NM_014162 20p11.23 Hs.584899 4    
213805_at ABHD5 abhydrolase domain containing 5 3 43707378 AI692428 3p21 Hs.19385 14

1-acylglycerol-3-phosphate O-acyltransferase activity

triacylglycerol lipase activity

protein binding

cytoplasm

cytosol

lipid metabolic process

fatty acid metabolic process

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

negative regulation of sequestering of triglyceride

positive regulation of triglyceride catabolic process

monolayer-surrounded lipid storage body

transferase activity

hydrolase activity

cell differentiation

lysophosphatidic acid acyltransferase activity

 
226281_at 0.717 2.831 2.135 4.938e-02 0.590 -3.893 DNER delta/notch-like EGF repeat containing 2 -229930588 BF059512 2q36.3 Hs.234074 9

neuron migration

transmembrane receptor activity

Notch binding

calcium ion binding

early endosome

plasma membrane

endocytosis

Notch receptor processing

synaptogenesis

central nervous system development

glial cell differentiation

integral to membrane

clathrin binding

dendrite

cell soma

skeletal muscle fiber development

 
201713_s_at RANBP2 RAN binding protein 2 2 108702368 D42063 2q12.3 Hs.199561 Hs.715056 61

peptidyl-prolyl cis-trans isomerase activity

protein binding

intracellular

nucleus

nuclear pore

cytosol

protein folding

protein import into nucleus

zinc ion binding

Ran GTPase binding

protein transport

isomerase activity

modification-dependent protein catabolic process

metal ion binding

intracellular transport

mRNA transport

intracellular protein transmembrane transport

 
1555515_a_at FAM189B family with sequence similarity 189, member B 1 -153483619 BC008854 1q21 Hs.348308 6

molecular_function

biological_process

membrane

integral to membrane

WW domain binding

 
222982_x_at SLC38A2 solute carrier family 38, member 2 12 -45038238 AF298897 12q Hs.221847 20

plasma membrane

ion transport

sodium ion transport

amino acid transport

symporter activity

integral to membrane

sodium ion binding

 
210479_s_at 0.816 6.339 2.921 1.041e-02 0.418 -2.591 RORA RAR-related orphan receptor A 15 -58567776, -58567776, -58567776 L14611 15q22.2 Hs.560343 Hs.655155 33

transcription factor activity

steroid hormone receptor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

nitric oxide biosynthetic process

signal transduction

zinc ion binding

cerebellar Purkinje cell differentiation

regulation of macrophage activation

sequence-specific DNA binding

positive regulation of transcription from RNA polymerase II promoter

cGMP metabolic process

metal ion binding

 
215711_s_at 0.444 5.266 2.180 4.540e-02 0.581 -3.825 WEE1 WEE1 homolog (S. pombe) 11 9551803, 9552809 AJ277546 11p15.3-p15.1 Hs.249441 61

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

non-membrane spanning protein tyrosine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

protein amino acid phosphorylation

cell cycle

mitosis

transferase activity

cell division

Cell cycle

223770_x_at MRI1 methylthioribose-1-phosphate isomerase homolog (S. cerevisiae) 19 13736336 BC001703 19p13.2 Hs.439370 11

cellular amino acid biosynthetic process

methionine biosynthetic process

isomerase activity

identical protein binding

cellular biosynthetic process

S-methyl-5-thioribose-1-phosphate isomerase activity

 
217792_at SNX5 sorting nexin 5 20 -17870243, -17870243 NM_014426 20p11 Hs.316890 14

protein binding

cell communication

protein transport

phosphoinositide binding

 
1554400_at -0.170 4.057 -2.176 4.571e-02 0.581 -3.830 TCTE3 t-complex-associated-testis-expressed 3 6 -169882139 AF519569 6q27 Hs.584808 3

membrane

 
212343_at YIPF6 Yip1 domain family, member 6 X 67635610 AL117461 Xq12 Hs.700646 Hs.82719 10

endoplasmic reticulum

membrane

integral to membrane

 
219091_s_at MMRN2 multimerin 2 10 -88685279 NM_024756 10q23.2 Hs.524479 Hs.719260 7

extracellular region

basement membrane

extracellular space

 
204068_at STK3 serine/threonine kinase 3 (STE20 homolog, yeast) 8 -99536036 NM_006281 8q22.2 Hs.492333 22

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

ATP binding

nucleus

cytoplasm

protein amino acid phosphorylation

signal transduction

protein kinase cascade

transferase activity

positive regulation of apoptosis

protein dimerization activity

MAPK signaling pathway

208223_s_at ACVR1B activin A receptor, type IB 12 50631752, 50631752, 50631752 NM_020327 12q13 Hs.438918 39

G1/S transition of mitotic cell cycle

nucleotide binding

magnesium ion binding

in utero embryonic development

hair follicle development

protein serine/threonine kinase activity

receptor activity

ATP binding

integral to plasma membrane

induction of apoptosis

signal transduction

transmembrane receptor protein serine/threonine kinase signaling pathway

embryonic development

cell surface

membrane

activin receptor activity, type I

transferase activity

peptidyl-threonine phosphorylation

growth factor binding

manganese ion binding

negative regulation of cell growth

ubiquitin protein ligase binding

positive regulation of activin receptor signaling pathway

regulation of transcription

positive regulation of erythrocyte differentiation

SMAD binding

protein amino acid autophosphorylation

activin binding

MAPK signaling pathway

Cytokine-cytokine receptor interaction

Endocytosis

TGF-beta signaling pathway

Adherens junction

Pathways in cancer

Colorectal cancer

Pancreatic cancer

Chronic myeloid leukemia

214363_s_at MATR3 matrin 3 5 138637690, 138657253 AA129420 5q31.2 Hs.268939 24

nucleotide binding

RNA binding

structural molecule activity

protein binding

intracellular

nucleus

nuclear inner membrane

zinc ion binding

nuclear matrix

metal ion binding

 
240200_at SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 2 108271526 AI307799 2q11.1-q11.2 Hs.436123 19

cytoplasm

cytoskeleton

sulfotransferase activity

amine metabolic process

transferase activity

 
220924_s_at 0.655 9.558 2.138 4.916e-02 0.590 -3.890 SLC38A2 solute carrier family 38, member 2 12 -45038238 NM_018976 12q Hs.221847 20

plasma membrane

ion transport

sodium ion transport

amino acid transport

symporter activity

integral to membrane

sodium ion binding

 
1554451_s_at DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14 12 -54501010 AF141342 12q13.2 Hs.709320 10

endoplasmic reticulum

protein folding

protein transport

membrane

integral to membrane

heat shock protein binding

unfolded protein binding

 
236009_at PERP PERP, TP53 apoptosis effector 6 -138451335 AI767250 6q24 Hs.201446 14

protein binding

mitochondrion

Golgi apparatus

plasma membrane

integral to plasma membrane

apoptosis

induction of apoptosis

cell adhesion

cell junction

desmosome

p53 signaling pathway

241403_at CLK4 CDC-like kinase 4 5 -177962270 AA468591 5q35 Hs.406557 7

nucleotide binding

protein serine/threonine kinase activity

protein tyrosine kinase activity

ATP binding

nucleus

transferase activity

peptidyl-tyrosine phosphorylation

protein amino acid autophosphorylation

 
242180_at TSPAN16 tetraspanin 16 19 11267823 AI688554 19p13.2 Hs.579784 2

membrane

integral to membrane

 
225115_at HIPK2 homeodomain interacting protein kinase 2 7 -138896855 BF529628 7q32-q34 Hs.397465 Hs.632033 66

nucleotide binding

transcription corepressor activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

cytoplasm

centrosome

protein amino acid phosphorylation

apoptosis

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

induction of apoptosis by intracellular signals

PML body

transferase activity

virus-host interaction

positive regulation of transforming growth factor beta receptor signaling pathway

nuclear membrane

regulation of transcription

positive regulation of transcription, DNA-dependent

positive regulation of JNK cascade

virion binding

 
205097_at SLC26A2 solute carrier family 26 (sulfate transporter), member 2 5 149320492 AI025519 5q31-q34 Hs.302738 24

transporter activity

membrane fraction

integral to plasma membrane

transport

secondary active sulfate transmembrane transporter activity

sulfate transport

membrane

 
203162_s_at KATNB1 katanin p80 (WD repeat containing) subunit B 1 16 56327160 NM_005886 16q21 Hs.275675 14

spindle pole

cytoplasm

cytoskeleton

microtubule

protein targeting

negative regulation of microtubule depolymerization

cell cycle

mitosis

microtubule binding

katanin complex

microtubule-severing ATPase activity

axon

positive regulation of microtubule depolymerization

dynein binding

protein heterodimerization activity

cell division

 
1554086_at TUBGCP3 tubulin, gamma complex associated protein 3 13 -112187328 BC007763 13q34 Hs.224152 8

structural constituent of cytoskeleton

protein binding

cytoplasm

centriole

polar microtubule

microtubule

microtubule nucleation

gamma-tubulin binding

 
1559520_at GYPA glycophorin A (MNS blood group) 4 -145249905 AL833104 4q28.2-q31.1 Hs.434973 60

membrane fraction

plasma membrane

integral to membrane

identical protein binding

Hematopoietic cell lineage

209232_s_at DCTN5 dynactin 5 (p25) 16 23560307 BC004191 16p12.2 Hs.435941 7

cytoplasm

cytoskeleton

transferase activity

 
220135_s_at -0.321 4.519 -2.517 2.349e-02 0.507 -3.277 SLC7A9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 19 -38013258 NM_014270 19q13.1 Hs.719221 34

plasma membrane

integral to plasma membrane

protein complex assembly

cellular amino acid metabolic process

transport

neutral amino acid transmembrane transporter activity

L-cystine transmembrane transporter activity

neutral amino acid transport

peptide antigen binding

 
206731_at CNKSR2 connector enhancer of kinase suppressor of Ras 2 X 21302900 NM_014927 Xp22.12 Hs.555917 10

protein binding

cytoplasm

centrosome

plasma membrane

regulation of signal transduction

 
214936_at LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 13 46025303 AW298219 13q14.13-q14.2 Hs.507971 Hs.595310 Hs.656722 Hs.681314 9

protein binding

 
228408_s_at SDAD1 SDA1 domain containing 1 4 -77090091 AI738666 4q21.1 Hs.632604 9

protein binding

nucleus

nucleolus

protein transport

ribosome biogenesis

 
216843_x_at PMS2L1 postmeiotic segregation increased 2-like 1 pseudogene 7 -99756198 U38964 7q22.1 Hs.634244 Hs.661055 Hs.709266 7

molecular_function

ATP binding

cellular_component

mismatch repair

biological_process

kinase activity

transferase activity

mismatched DNA binding

 
1553227_s_at 0.355 5.098 2.503 2.416e-02 0.511 -3.301 BRWD1 bromodomain and WD repeat domain containing 1 21 -39590234, -39484017, -39479273 NM_018963 21q22.2 Hs.654740 8

protein binding

nucleus

cytoplasm

regulation of transcription from RNA polymerase II promoter

biological_process

transcription regulator activity

regulation of transcription

 
239438_at RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 5 -130789502 AW169970 5q31.1 Hs.483329 13

guanyl-nucleotide exchange factor activity

intracellular

cytoplasm

plasma membrane

signal transduction

Ras protein signal transduction

Ras GTPase binding

GTP-dependent protein binding

regulation of GTPase activity

regulation of small GTPase mediated signal transduction

 
221558_s_at LEF1 lymphoid enhancer-binding factor 1 4 -109188149 AF288571 4q23-q25 Hs.719332 85

negative regulation of transcription from RNA polymerase II promoter

somitogenesis

epithelial to mesenchymal transition

placenta development

chromatin binding

RNA polymerase II transcription factor activity, enhancer binding

protein binding

nucleus

transcription factor complex

nucleolus

cytoplasm

DNA bending activity

transcription activator activity

dentate gyrus development

regulation of Wnt receptor signaling pathway

embryonic limb morphogenesis

mammary gland development

odontogenesis of dentine-containing tooth

sequence-specific DNA binding

regulation of transcription

negative regulation of striated muscle development

positive regulation of transcription from RNA polymerase II promoter

paraxial mesoderm formation

cell development

palate development

Wnt signaling pathway

Adherens junction

Melanogenesis

Pathways in cancer

Colorectal cancer

Endometrial cancer

Prostate cancer

Thyroid cancer

Basal cell carcinoma

Acute myeloid leukemia

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

1552682_a_at CASC5 cancer susceptibility candidate 5 15 38673738 NM_144508 15q14 Hs.181855 16

acrosomal vesicle

acrosome assembly

protein binding

nucleus

 
222869_s_at ELAC1 elaC homolog 1 (E. coli) 18 46748384 AI669235 18q21 Hs.657360 9

endonuclease activity

nucleus

tRNA processing

zinc ion binding

hydrolase activity

metal ion binding

 
1553663_a_at -0.282 7.600 -2.973 9.364e-03 0.401 -2.500 NPB neuropeptide B 17 77453363, 2419653 NM_148896 17q25.3 Hs.585089 Hs.708916 5

protein binding

extracellular region

neuropeptide signaling pathway

 
1562844_at LOC339822 hypothetical protein LOC339822 2   BC043553 2p25.3 Hs.651879 1    
224392_s_at -0.520 4.446 -3.629 2.424e-03 0.284 -1.351 OPN3 opsin 3 1 -239823074 AF303588 1q43 Hs.409081 Hs.719236 10

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

visual perception

phototransduction

G-protein coupled photoreceptor activity

membrane

protein-chromophore linkage

regulation of circadian rhythm

response to stimulus

 
224897_at WDR26 WD repeat domain 26 1 -222639467 BF510490 1q42.11-q42.12 Hs.497873 8

cytoplasm

 
219568_x_at SOX18 SRY (sex determining region Y)-box 18 20 -62149522 NM_018419 20q13.33 Hs.8619 20

angiogenesis

vasculogenesis

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

regulation of transcription from RNA polymerase II promoter

 
237755_s_at -0.198 3.810 -2.269 3.821e-02 0.565 -3.682 WDR16 WD repeat domain 16 17 9420668 AW673231 17p13.1 Hs.232270 5

protein binding

cytoplasm

 
230089_s_at C19orf6 chromosome 19 open reading frame 6 19 -960649 AA829838 19p13.3 Hs.515003 6

cytoplasm

membrane

integral to membrane

 
228318_s_at CRIPAK cysteine-rich PAK1 inhibitor 4 1375339 AI356283 4p16.3 Hs.26410 3

protein binding

nucleus

cytoplasm

endoplasmic reticulum

plasma membrane

negative regulation of protein kinase activity

ER-nuclear signaling pathway

response to estrogen stimulus

regulation of cytoskeleton organization

 
210719_s_at 0.426 5.457 2.968 9.468e-03 0.402 -2.510 HMG20B high-mobility group 20B 19 3523942 BC002552 19p13.3 Hs.406534 18

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

cell cycle

chromatin modification

 
234950_s_at RFWD2 ring finger and WD repeat domain 2 1 -174180589 AK001278 1q25.1-q25.2 Hs.523744 12

protein binding

nucleus

cytoplasm

zinc ion binding

nuclear speck

ligase activity

modification-dependent protein catabolic process

metal ion binding

p53 signaling pathway

Ubiquitin mediated proteolysis

1564504_at -0.302 4.101 -2.327 3.417e-02 0.553 -3.590 ACCN5 amiloride-sensitive cation channel 5, intestinal 4 -156970330 AJ252011 4q31.3-q32 Hs.381349 1

ion channel activity

sodium channel activity

plasma membrane

ion transport

sodium ion transport

integral to membrane

sodium ion binding

 
218702_at SARS2 seryl-tRNA synthetase 2, mitochondrial 19 -44097743 NM_017827 19q13.2 Hs.709416 11

nucleotide binding

serine-tRNA ligase activity

protein binding

ATP binding

cytoplasm

mitochondrion

mitochondrial matrix

seryl-tRNA aminoacylation

ligase activity

Aminoacyl-tRNA biosynthesis

230802_at 0.602 3.816 2.617 1.925e-02 0.489 -3.110 ARHGAP24 Rho GTPase activating protein 24 4 86615307, 86918874, 87070449 AI761947 4q21.23-q21.3 Hs.444229 14

angiogenesis

GTPase activator activity

protein binding

intracellular

cytoplasm

cytoskeleton

adherens junction

focal adhesion

signal transduction

multicellular organismal development

cell junction

cell differentiation

cell projection

 
224984_at NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 16 68156497 W61007 16q22.1 Hs.371987 35

cytokine production

transcription factor activity

RNA polymerase II transcription factor activity

protein binding

nucleus

cytoplasm

regulation of transcription, DNA-dependent

signal transduction

excretion

positive regulation of transcription from RNA polymerase II promoter

Wnt signaling pathway

Axon guidance

VEGF signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

1552904_at -0.235 2.094 -2.248 3.985e-02 0.568 -3.717 NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 18 -68652254, -68565766, -68565766 NM_138999 18q22-q23 Hs.465407 4

receptor activity

extracellular region

plasma membrane

integral to membrane

 
205084_at BCAP29 B-cell receptor-associated protein 29 7 107007657, 107008439 NM_018844 7q22-q31 Hs.303787 12

endoplasmic reticulum

intracellular protein transport

apoptosis

membrane

integral to membrane

vesicle-mediated transport

 
224860_at -0.554 6.256 -2.131 4.980e-02 0.591 -3.900 C9orf123 chromosome 9 open reading frame 123 9 -7786490 AL137489 9p24.1 Hs.7517 4

membrane

integral to membrane

 
221012_s_at TRIM8 tripartite motif-containing 8 10 104394241 NM_030912 10q24.3 Hs.336810 7

protein binding

biological_process

zinc ion binding

PML body

protein homodimerization activity

metal ion binding

 
209719_x_at SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 18 -59473410 U19556 18q21.3 Hs.227948 37

serine-type endopeptidase inhibitor activity

protein binding

cytoplasm

peptidase inhibitor activity

 
201412_at LRP10 low density lipoprotein receptor-related protein 10 14 22410799 NM_014045 14q11.2 Hs.525232 9

receptor activity

low-density lipoprotein receptor activity

coated pit

lipid metabolic process

lipid transport

endocytosis

membrane

integral to membrane

 
205483_s_at ISG15 ISG15 ubiquitin-like modifier 1 938709 NM_005101 1p36.33 Hs.458485 61

protein binding

extracellular region

extracellular space

cytoplasm

cell-cell signaling

response to virus

modification-dependent protein catabolic process

protein tag

ISG15-protein conjugation

interspecies interaction between organisms

RIG-I-like receptor signaling pathway

232512_at SCN3A sodium channel, voltage-gated, type III, alpha subunit 2 -165652275 AB037777 2q24 Hs.435274 16

voltage-gated sodium channel complex

voltage-gated ion channel activity

voltage-gated sodium channel activity

ion transport

sodium ion transport

membrane

integral to membrane

sodium ion binding

 
242912_at -0.377 4.911 -2.379 3.088e-02 0.542 -3.506 P704P prostate-specific P704P 14 -19053953 AI041215 14q11.2 Hs.654289 3    
205202_at PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 6 150112523 NM_005389 6q24-q25 Hs.279257 25

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

cellular_component

cytoplasm

endoplasmic reticulum

protein modification process

protein amino acid methylation

methyltransferase activity

transferase activity

protein repair

identical protein binding

 
201923_at PRDX4 peroxiredoxin 4 X 23595565 NM_006406 Xp22.11 Hs.83383 15

cytoplasm

mitochondrion

I-kappaB phosphorylation

thioredoxin peroxidase activity

oxidoreductase activity

cell redox homeostasis

oxidation reduction

 
228286_at GEN1 Gen homolog 1, endonuclease (Drosophila) 2 17798657, 17798894 AK025489 2p24.2 Hs.467793 4

magnesium ion binding

DNA binding

endonuclease activity

nucleus

DNA repair

response to DNA damage stimulus

hydrolase activity

 
243296_at -0.929 5.401 -3.265 5.145e-03 0.347 -1.991 NAMPT nicotinamide phosphoribosyltransferase 7 -105675967 AA873350 7q22.3 Hs.489615 98

cytokine activity

cytoplasm

cytosol

signal transduction

cell-cell signaling

positive regulation of cell proliferation

NAD biosynthetic process

transferase activity, transferring glycosyl groups

pyridine nucleotide biosynthetic process

nicotinamide phosphoribosyltransferase activity

nicotinamide phosphoribosyltransferase activity

Nicotinate and nicotinamide metabolism

207063_at NCRNA00185 non-protein coding RNA 185 Y -19493776 NM_018542 Yq11.222 Hs.138453 1    
217413_s_at TNXB tenascin XB 6 -32116910, -32116910, -3416089, -3416089, -3223932, -3223932 X71923 6p21.3 Hs.42853 Hs.485104 42

integrin binding

extracellular region

proteinaceous extracellular matrix

fibrillar collagen

intracellular

cell adhesion

signal transduction

heparin binding

actin cytoskeleton organization

collagen metabolic process

elastic fiber assembly

Focal adhesion

ECM-receptor interaction

210864_x_at HFE hemochromatosis 6 26195487 AF144240 6p21.3 Hs.233325 592

antigen processing and presentation of peptide antigen via MHC class I

iron ion binding

protein binding

cytoplasm

early endosome

plasma membrane

integral to plasma membrane

protein complex assembly

ion transport

iron ion transport

cellular iron ion homeostasis

receptor-mediated endocytosis

immune response

antigen processing and presentation

cytoplasmic vesicle

MHC class I protein complex

apical part of cell

basal part of cell

perinuclear region of cytoplasm

recycling endosome

 
221478_at 0.422 7.092 2.491 2.475e-02 0.513 -3.321 BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 8 26296439 AL132665 8p21 Hs.131226 19

lamin binding

lamin binding

nucleus

nuclear envelope

mitochondrion

mitochondrial envelope

endoplasmic reticulum

induction of apoptosis

negative regulation of survival gene product expression

membrane

integral to membrane

protein homodimerization activity

negative regulation of apoptosis

interspecies interaction between organisms

protein heterodimerization activity

defense response to virus

 
222723_at VWA1 von Willebrand factor A domain containing 1 1 1360771 AW292148 1p36.33 Hs.449009 6

extracellular region

basement membrane

 
243277_x_at MECOM MDS1 and EVI1 complex locus 3 -170283980, -170283980, -170283980, -170283980 AI458437 3q24-q28 Hs.659873 Hs.719216 46

molecular_function

DNA binding

transcription factor activity

protein binding

intracellular

nucleus

multicellular organismal development

biological_process

zinc ion binding

metal ion binding

MAPK signaling pathway

Pathways in cancer

Chronic myeloid leukemia

1566701_at VRK3 vaccinia related kinase 3 19 -55171535 AK074461 19q13 Hs.443330 7

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

protein amino acid phosphorylation

transferase activity

 
219153_s_at THSD4 thrombospondin, type I, domain containing 4 15 69220841 NM_024817 15q23 Hs.387057 6

metalloendopeptidase activity

extracellular region

proteinaceous extracellular matrix

peptidase activity

 
225497_at ATE1 arginyltransferase 1 10 -123492614 AL589591 10q26.13 Hs.632080 6

arginyltransferase activity

nucleus

cytoplasm

acyltransferase activity

protein arginylation

transferase activity

modification-dependent protein catabolic process

 
224703_at 0.305 7.580 2.219 4.209e-02 0.575 -3.762 DCAF5 DDB1 and CUL4 associated factor 5 14 -68587390 AI814644 14q23-q24.1 Hs.509780 6    
1570015_at RP11-165H20.1 CHIA-like pseudogene 1 111624668 BC031662 1p13.2   1    
1007_s_at 0.442 7.747 2.269 3.822e-02 0.565 -3.683 DDR1 discoidin domain receptor tyrosine kinase 1 6 30959839, 30960305, 30964443, 2300465, 2300931, 2305069, 2098794, 2099260, 2103398 U48705 6p21.3 Hs.631988 60

nucleotide binding

transmembrane receptor protein tyrosine kinase activity

receptor activity

protein binding

ATP binding

extracellular region

integral to plasma membrane

protein amino acid phosphorylation

cell adhesion

transmembrane receptor protein tyrosine kinase signaling pathway

membrane

transferase activity

 
205284_at URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 1 227828603 NM_014777 1q42.13 Hs.533628 5

nucleus

nucleolus

 
219015_s_at ALG13 asparagine-linked glycosylation 13 homolog (S. cerevisiae) X 110811068 NM_018466 Xq23 Hs.443061 14

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity

endoplasmic reticulum

carbohydrate metabolic process

transferase activity, transferring hexosyl groups

carbohydrate binding

lipid glycosylation

N-Glycan biosynthesis

Metabolic pathways

225486_at ARID2 AT rich interactive domain 2 (ARID, RFX-like) 12 44409886 AB046777 12q12 Hs.317304 13

DNA binding

protein binding

intracellular

nucleus

zinc ion binding

chromatin modification

regulation of transcription

metal ion binding

 
214036_at EFNA5 ephrin-A5 5 -106740488 BE464799 5q21 Hs.288741 27

protein binding

extracellular space

plasma membrane

cell-cell signaling

multicellular organismal development

nervous system development

cell differentiation

anchored to plasma membrane

ephrin receptor binding

Axon guidance

206342_x_at IDS iduronate 2-sulfatase X -148376566, -148368202 NM_006123 Xq28 Hs.460960 73

iduronate-2-sulfatase activity

calcium ion binding

lysosome

metabolic process

hydrolase activity

glycosaminoglycan metabolic process

Glycosaminoglycan degradation

Metabolic pathways

Lysosome

217182_at MUC5AC mucin 5AC, oligomeric mucus/gel-forming 11 1132473 Z34282 11p15.5 Hs.534332 Hs.558950 95

molecular_function

protein binding

extracellular region

apoptosis

induction of apoptosis

cell adhesion

digestion

biological_process

negative regulation of cell proliferation

extracellular matrix constituent, lubricant activity

negative regulation of cell migration

fibril

fibril organization

 
231299_at 0.353 4.575 3.344 4.370e-03 0.328 -1.852 AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 7 150414758, 150414758 AI494590 7q36.1 Hs.647075 8

nucleotide binding

GTP binding

intracellular

cytoplasm

small GTPase mediated signal transduction

ARF GTPase activator activity

zinc ion binding

regulation of ARF GTPase activity

metal ion binding

 
210081_at AGER advanced glycosylation end product-specific receptor 6 -32256723, -3555933, -3363712 AB036432 6p21.3 Hs.534342 212

transmembrane receptor activity

protein binding

extracellular region

plasma membrane

integral to plasma membrane

inflammatory response

cell surface receptor linked signal transduction

 
1564490_at LOC100128830 hypothetical protein LOC100128830 10   AK097584 10q26.3 Hs.638406 1    
209292_at ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 6 19945595 AL022726 6p22-p21 Hs.519601 23

G1/S transition of mitotic cell cycle

transcription corepressor activity

protein binding

nucleus

nucleus

regulation of transcription from RNA polymerase II promoter

neuroblast proliferation

brain development

positive regulation of cell proliferation

negative regulation of transcription

hippocampus development

cerebral cortex neuron differentiation

negative regulation of neuron differentiation

negative regulation of astrocyte differentiation

TGF-beta signaling pathway

232165_at -0.303 3.614 -2.316 3.489e-02 0.555 -3.607 EPPK1 epiplakin 1 8 -145011899 AL137725 8q24.3 Hs.200412 11

structural molecule activity

protein binding

cytoplasm

cytoskeleton

biological_process

 
221706_s_at USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 19 17187154 BC006005 19p13.11 Hs.16187 12

protein binding

lysosome

endoplasmic reticulum

ER to Golgi vesicle-mediated transport

lysosomal transport

protein transport

membrane

integral to membrane

vesicle-mediated transport

protein catabolic process

SNARE interactions in vesicular transport

204794_at DUSP2 dual specificity phosphatase 2 2 -96172634 NM_004418 2q11 Hs.1183 16

inactivation of MAPK activity

protein tyrosine phosphatase activity

nucleus

protein amino acid dephosphorylation

protein tyrosine/threonine phosphatase activity

hydrolase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

mitogen-activated protein kinase binding

MAPK signaling pathway

202594_at 0.352 6.966 2.402 2.949e-02 0.536 -3.467 LEPROTL1 leptin receptor overlapping transcript-like 1 8 30072463, 30072463 NM_015344 8p21.2-p21.1 Hs.146585 8

membrane

integral to membrane

 
200093_s_at 0.304 10.848 2.606 1.968e-02 0.491 -3.129 HINT1 histidine triad nucleotide binding protein 1 5 -130522773, -130522773 N32864 5q31.2 Hs.483305 26

protein kinase C binding

nucleus

cytoplasm

cytoskeleton

signal transduction

hydrolase activity

 
206311_s_at PLA2G1B phospholipase A2, group IB (pancreas) 12 -119244296 NM_000928 12q23-q24.1 Hs.992 44

activation of MAPK activity

neutrophil mediated immunity

receptor binding

calcium ion binding

extracellular region

extracellular space

fatty acid biosynthetic process

phospholipid metabolic process

actin filament organization

signal transduction

protein kinase cascade

positive regulation of calcium ion transport into cytosol

positive regulation of specific transcription from RNA polymerase II promoter

glucose transport

hydrolase activity

leukotriene biosynthetic process

neutrophil chemotaxis

bile acid binding

activation of phospholipase A2 activity

interleukin-8 production

cellular response to insulin stimulus

cell surface binding

multicellular organismal lipid catabolic process

positive regulation of DNA replication

phosphatidylcholine metabolic process

calcium-dependent phospholipase A2 activity

positive regulation of fibroblast proliferation

arachidonic acid secretion

positive regulation of protein secretion

positive regulation of immune response

positive regulation of NF-kappaB transcription factor activity

Glycerophospholipid metabolism

Ether lipid metabolism

Arachidonic acid metabolism

Linoleic acid metabolism

alpha-Linolenic acid metabolism

Metabolic pathways

MAPK signaling pathway

Vascular smooth muscle contraction

VEGF signaling pathway

Fc epsilon RI signaling pathway

Long-term depression

GnRH signaling pathway

235197_s_at 0.342 3.827 2.322 3.449e-02 0.553 -3.598 OSTM1 osteopetrosis associated transmembrane protein 1 6 -108469305 AV713913 6q21 Hs.226780 Hs.706947 Hs.719130 16

protein binding

cytosol

membrane

integral to membrane

osteoclast differentiation

 
220683_at RDH8 retinol dehydrogenase 8 (all-trans) 19 9984924 NM_015725 19p13.2-p13.3 Hs.675522 9

estradiol 17-beta-dehydrogenase activity

retinol dehydrogenase activity

binding

cytoplasm

integral to plasma membrane

estrogen biosynthetic process

visual perception

membrane

oxidoreductase activity

response to stimulus

oxidation reduction

Retinol metabolism

Metabolic pathways

205757_at ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 14 -73502935 NM_001249 14q24 Hs.131555 14

magnesium ion binding

calcium ion binding

endoplasmic reticulum

endoplasmic reticulum lumen

hydrolase activity

nucleoside-diphosphatase activity

Purine metabolism

Pyrimidine metabolism

233134_at RPH3AL rabphilin 3A-like (without C2 domains) 17 -62293 T74766 17p13.3 Hs.651925 15

cytoplasm

intracellular protein transport

exocytosis

cytoskeletal protein binding

zinc ion binding

membrane

Rab GTPase binding

secretory granule membrane

cytoplasmic vesicle

metal ion binding

 
241402_at TSEN54 tRNA splicing endonuclease 54 homolog (S. cerevisiae) 17 71024203 AA504269 17q25.1 Hs.655875 6

nucleus

nucleolus

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA processing

 
204537_s_at GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon X -150872251 NM_004961 Xq28 Hs.22785 17

GABA-A receptor activity

ion channel activity

extracellular ligand-gated ion channel activity

chloride channel activity

plasma membrane

integral to plasma membrane

ion transport

gamma-aminobutyric acid signaling pathway

cell junction

neurotransmitter receptor activity

chloride ion binding

chloride channel complex

synapse

postsynaptic membrane

Neuroactive ligand-receptor interaction

225053_at CNOT7 CCR4-NOT transcription complex, subunit 7 8 -17133392, -17131110 W94952 8p22-p21.3 Hs.645009 Hs.719129 19

nucleic acid binding

transcription factor activity

signal transducer activity

protein binding

nucleus

carbohydrate metabolic process

signal transduction

transcription activator activity

CCR4-NOT complex

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

RNA degradation

1554397_s_at UEVLD UEV and lactate/malate dehyrogenase domains 11 -18509819 BC011011 11p15.1 Hs.407991 5

binding

glycolysis

metabolic process

protein transport

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

small conjugating protein ligase activity

modification-dependent protein catabolic process

post-translational protein modification

cellular carbohydrate metabolic process

regulation of protein metabolic process

 
206158_s_at CNBP CCHC-type zinc finger, nucleic acid binding protein 3 -130369347 NM_003418 3q21 Hs.518249 24

transcription factor activity

protein binding

cytoplasm

endoplasmic reticulum

regulation of transcription, DNA-dependent

cholesterol biosynthetic process

zinc ion binding

metal ion binding

 
232620_at WDR93 WD repeat domain 93 15 88035031 AL390084 15q26.1 Hs.177557 2    
220096_at RNASET2 ribonuclease T2 6 -167262993 NM_017795 6q27 Hs.529989 11

RNA binding

endonuclease activity

ribonuclease activity

extracellular region

RNA catabolic process

hydrolase activity

ribonuclease T2 activity

 
227993_at METAP2 methionyl aminopeptidase 2 12 94391952 AW003997 12q22 Hs.444986 35

aminopeptidase activity

cytoplasm

proteolysis

peptidase activity

metalloexopeptidase activity

cellular process

protein processing

peptidyl-methionine modification

N-terminal protein amino acid modification

metal ion binding

cobalt ion binding

 
213058_at TTC28 tetratricopeptide repeat domain 28 22 -26704003 AL033538 22q12.1 Hs.387856 Hs.719265 6

binding

 
200611_s_at WDR1 WD repeat domain 1 4 -9685060 AB010427 4p16.1 Hs.128548 Hs.713658 15

actin binding

protein binding

cytoplasm

cytoskeleton

sensory perception of sound

 
220849_at LOC79999 hypothetical LOC79999 17   NM_024934 17p11.2 Hs.677375 3    
204582_s_at KLK3 kallikrein-related peptidase 3 19 56049982, 56049982 NM_001648 19q13.41 Hs.171995 191

serine-type endopeptidase activity

extracellular region

proteolysis

peptidase activity

negative regulation of angiogenesis

Pathways in cancer

Prostate cancer

215174_at -0.238 3.911 -2.547 2.217e-02 0.499 -3.228 FMO6P flavin containing monooxygenase 6 pseudogene 1 169373502 AL021026 1q24.3 Hs.448988 4

monooxygenase activity

flavin-containing monooxygenase activity

endoplasmic reticulum

microsome

membrane

integral to membrane

intrinsic to endoplasmic reticulum membrane

FAD binding

NADP or NADPH binding

oxidation reduction

 
226888_at 0.317 5.041 2.902 1.083e-02 0.421 -2.624 CSNK1G1 casein kinase 1, gamma 1 15 -62244768 BG104860 15q22.1-q22.31 Hs.646508 10

nucleotide binding

protein serine/threonine kinase activity

ATP binding

cytoplasm

protein amino acid phosphorylation

Wnt receptor signaling pathway

transferase activity

Hedgehog signaling pathway

205549_at PCP4 Purkinje cell protein 4 21 40161216 NM_006198 21q22.2 Hs.80296 9

nucleus

cytosol

central nervous system development

 
202336_s_at 0.573 10.263 3.093 7.317e-03 0.376 -2.291 PAM peptidylglycine alpha-amidating monooxygenase 5 102229425 NM_000919 5q14-q21 Hs.369430 34

monooxygenase activity

peptidylglycine monooxygenase activity

peptidylamidoglycolate lyase activity

copper ion binding

protein binding

extracellular region

protein modification process

peptide metabolic process

zinc ion binding

cellular process

membrane

integral to membrane

lyase activity

secretory granule

L-ascorbic acid binding

metal ion binding

oxidation reduction

 
226453_at RNASEH2C ribonuclease H2, subunit C 11 -65241719 BF982002 11q13.1 Hs.718438 9

nucleus

DNA replication

210118_s_at -0.272 4.076 -2.246 4.000e-02 0.568 -3.720 IL1A interleukin 1, alpha 2 -113247962 M15329 2q14 Hs.1722 540

fever

cytokine activity

interleukin-1 receptor binding

protein binding

extracellular region

extracellular space

apoptosis

anti-apoptosis

inflammatory response

immune response

negative regulation of cell proliferation

positive regulation vascular endothelial growth factor production

cytokine-mediated signaling pathway

positive regulation of interleukin-2 biosynthetic process

positive regulation of angiogenesis

positive regulation of mitosis

positive regulation of cytokine secretion

MAPK signaling pathway

Cytokine-cytokine receptor interaction

Apoptosis

Hematopoietic cell lineage

Type I diabetes mellitus

Prion diseases

Graft-versus-host disease

212928_at TSPYL4 TSPY-like 4 6 -116677823 AL050331 6q22.1 Hs.284141 7

nucleus

nucleosome assembly

 
203068_at KLHL21 kelch-like 21 (Drosophila) 1 -6573370 NM_014851 1p36.31 Hs.7764 5

protein binding

modification-dependent protein catabolic process

 
236328_at 0.286 4.744 2.375 3.114e-02 0.543 -3.513 ZNF285A zinc finger protein 285A 19 -49581647 AW513227   Hs.709428 4

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
241009_at FOXN4 forkhead box N4 12 -108200165 AI243313 12q24.11 Hs.528316 6

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

sequence-specific DNA binding

 
1554516_at -0.301 6.898 -2.457 2.650e-02 0.522 -3.378 LOC203274 hypothetical protein LOC203274 9   BC011779 9q21.11 Hs.599821 1    
206973_at -0.315 4.454 -2.571 2.112e-02 0.497 -3.188 PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 12 -80177486 NM_003625 12q21.31 Hs.506216 7

protein binding

cytoplasm

cell-matrix adhesion

cell surface

 
227837_at LOC729570 hypothetical LOC729570 2   BF057711 2q33.3        
224636_at ZFP91 zinc finger protein 91 homolog (mouse) 11 58103162 AL045405 11q12 Hs.524920 10

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
227161_at NOM1 nucleolar protein with MIF4G domain 1 7 156435177 AI419857 7q36.3 Hs.15825 6

protein binding

nucleus

nucleolus

biological_process

RNA metabolic process

 
240088_at PDE5A phosphodiesterase 5A, cGMP-specific 4 -120634997, -120634997, -120634997 BG494416 4q25-q27 Hs.587281 Hs.647971 43

nucleotide binding

magnesium ion binding

cellular_component

signal transduction

zinc ion binding

cyclic nucleotide metabolic process

hydrolase activity

cGMP binding

3',5'-cyclic-GMP phosphodiesterase activity

Purine metabolism

203017_s_at SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 1 -84882184 R52678 1p22.3 Hs.22587 14

protein binding

nucleus

adherens junction

cell adhesion

cell junction

protein complex

Adherens junction

1563321_s_at -0.356 4.279 -2.731 1.533e-02 0.457 -2.918 MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 10 21863107, 21863579 AF272384 10p12 Hs.30385 19

transcription factor activity

protein binding

nucleus

cytoplasm

zinc ion binding

metal ion binding

 
217595_at GSPT1 G1 to S phase transition 1 16 -11869485, -11869485 AV701723 16p13.1 Hs.528780 27

G1/S transition of mitotic cell cycle

nucleotide binding

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

translation release factor activity

GTPase activity

protein binding

GTP binding

intracellular

translation

protein amino acid methylation

 
233288_at ATR ataxia telangiectasia and Rad3 related 3 -143650766 AU143947 3q22-q24 Hs.271791 186

DNA damage checkpoint

nucleotide binding

XY body

DNA binding

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

chromosome

DNA repair

protein amino acid phosphorylation

response to DNA damage stimulus

cell cycle

multicellular organismal development

negative regulation of DNA replication

transferase activity

manganese ion binding

MutLalpha complex binding

MutSalpha complex binding

regulation of protein binding

Cell cycle

p53 signaling pathway

1569383_s_at ZFYVE28 zinc finger, FYVE domain containing 28 4 -2241122 BC032605 4p16.3 Hs.292056 3

protein binding

cytoplasm

endosome

cytosol

negative regulation of epidermal growth factor receptor activity

zinc ion binding

membrane

early endosome membrane

phosphatidylinositol 3-phosphate binding

metal ion binding

 
1564295_at FLJ25917 hypothetical gene supported by AK098783 X   AK098783 Xp11.3 Hs.633348      
236382_at WDR8 WD repeat domain 8 1 -3537191 AW572779 1p36.3 Hs.31714 8

protein binding

cytoplasm

 
207131_x_at GGT1 gamma-glutamyltransferase 1 22 23309717, 23329179, 23333654 NM_013430 22q11.23 Hs.595809 Hs.645535 71

molecular_function

gamma-glutamyltransferase activity

protein binding

cellular amino acid metabolic process

glutathione biosynthetic process

acyltransferase activity

membrane

integral to membrane

transferase activity

Taurine and hypotaurine metabolism

Selenoamino acid metabolism

Cyanoamino acid metabolism

Glutathione metabolism

Arachidonic acid metabolism

Metabolic pathways

227374_at EARS2 glutamyl-tRNA synthetase 2, mitochondrial (putative) 16 -23440834 AA833716 16p12.2 Hs.620541 6

nucleotide binding

RNA binding

glutamate-tRNA ligase activity

ATP binding

cytoplasm

mitochondrion

mitochondrial matrix

glutamyl-tRNA aminoacylation

ligase activity

Porphyrin and chlorophyll metabolism

Aminoacyl-tRNA biosynthesis

Metabolic pathways

219736_at TRIM36 tripartite motif-containing 36 5 -114541134, -114534698, -114488357 NM_018700 5q22.3 Hs.519514 Hs.638953 5

acrosomal vesicle

protein binding

intracellular

cytoplasm

acrosome reaction

zinc ion binding

metal ion binding

 
227961_at CTSB cathepsin B 8 -11737442 AA130998 8p22 Hs.520898 140

cysteine-type endopeptidase activity

extracellular region

intracellular

soluble fraction

mitochondrion

lysosome

proteolysis

peptidase activity

response to wounding

external side of plasma membrane

apical plasma membrane

kininogen binding

peptide binding

melanosome

regulation of apoptosis

regulation of catalytic activity

Lysosome

Antigen processing and presentation

223125_s_at C1orf21 chromosome 1 open reading frame 21 1 182622772 AL563236 1q25 Hs.497159 Hs.719188 8    
209990_s_at GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 9 -100090186 AF056085 9q22.1-q22.3 Hs.198612 27

receptor activity

G-protein coupled receptor activity

GABA-B receptor activity

protein binding

cytoplasm

plasma membrane

integral to plasma membrane

signal transduction

negative regulation of adenylate cyclase activity

gamma-aminobutyric acid signaling pathway

synaptic transmission

cell junction

neuron projection

synapse

postsynaptic membrane

Neuroactive ligand-receptor interaction

208625_s_at EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 3 185515049, 185515664, 185520956 AF104913 3q27-qter Hs.433750 91

RNA binding

translation initiation factor activity

protein binding

cytoplasm

cytosol

regulation of translational initiation

RNA metabolic process

eukaryotic translation initiation factor 4F complex

interspecies interaction between organisms

 
213465_s_at PPP1R7 protein phosphatase 1, regulatory (inhibitor) subunit 7 2 241738574 BF718769 2q37.3 Hs.36587 10

protein binding

nucleus

cytoplasm

biological_process

protein phosphatase type 1 regulator activity

enzyme regulator activity

 
201410_at PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2 131578889 AI983043 2q21.1 Hs.469944 Hs.711433 11

protein binding

membrane

 
218032_at SNN stannin 16 11669801 AF070673 16p13 Hs.700592 11

response to stress

response to abiotic stimulus

membrane

integral to membrane

 
244353_s_at -0.757 6.558 -4.289 6.274e-04 0.211 -0.208 SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 6 -134350411 AI675682 6q23.2 Hs.486508 11

transporter activity

cytoplasm

carbohydrate transport

membrane

integral to membrane

substrate-specific transmembrane transporter activity

perinuclear region of cytoplasm

transmembrane transport

 
218386_x_at USP16 ubiquitin specific peptidase 16 21 29318808 NM_006447 21q22.11 Hs.99819 15

transcription coactivator activity

cysteine-type endopeptidase activity

ubiquitin thiolesterase activity

ubiquitin-specific protease activity

nucleus

cytoplasm

ubiquitin-dependent protein catabolic process

cell cycle

mitosis

peptidase activity

zinc ion binding

chromatin modification

histone deubiquitination

histone binding

ubiquitin binding

regulation of transcription

positive regulation of transcription, DNA-dependent

metal ion binding

protein homotetramerization

cell division

 
1553539_at KRT74 keratin 74 12 -51245869 NM_175053 12q13.13 Hs.660125 5

keratin filament

 
226902_at USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 3 180853626 BF109140 3q26.2-q26.3 Hs.175322 11

cysteine-type endopeptidase activity

ubiquitin thiolesterase activity

ubiquitin-specific protease activity

ubiquitin-dependent protein catabolic process

peptidase activity

zinc ion binding

metal ion binding

 
1555308_at -0.220 6.034 -2.453 2.666e-02 0.523 -3.383 CARD14 caspase recruitment domain family, member 14 17 75766875, 75776193 BC018142 17q25 Hs.675480 Hs.696253 7

positive regulation of protein amino acid phosphorylation

protein binding

intracellular

cytoplasm

plasma membrane

activation of NF-kappaB-inducing kinase activity

regulation of apoptosis

CARD domain binding

 
214191_at ICA1 islet cell autoantigen 1, 69kDa 7 -8119928, -8119339, -8119339 W67992 7p22 Hs.487561 27

Golgi membrane

molecular_function

protein binding

cytoplasm

Golgi apparatus

cytosol

neurotransmitter transport

membrane

cell junction

secretory granule membrane

synaptic vesicle membrane

cytoplasmic vesicle

synapse

Type I diabetes mellitus

219293_s_at OLA1 Obg-like ATPase 1 2 -174645420 NM_013341 2q31.1 Hs.157351 11

nucleotide binding

protein binding

ATP binding

GTP binding

intracellular

cytoplasm

ATP catabolic process

hydrolase activity

 
223993_s_at CNIH4 cornichon homolog 4 (Drosophila) 1 222611217 AL136930 1q42.11 Hs.195403 Hs.445890 11

protein binding

endoplasmic reticulum

intracellular signaling cascade

membrane

integral to membrane

 
226274_at CLCN5 chloride channel 5 X 49573964, 49718954 AK025562 Xp11.23-p11.22 Hs.166486 45

nucleotide binding

ion channel activity

voltage-gated chloride channel activity

ATP binding

endosome

Golgi apparatus

plasma membrane

integral to plasma membrane

ion transport

chloride transport

endocytosis

excretion

antiporter activity

chloride ion binding

apical part of cell

 
219756_s_at POF1B premature ovarian failure, 1B X -84419050 NM_024921 Xq21.1-q21.2 Hs.267038 10

actin binding

 
202117_at 0.357 7.782 2.303 3.579e-02 0.557 -3.628 ARHGAP1 Rho GTPase activating protein 1 11 -46655207 BG468434 11p12-q12 Hs.138860 39

ruffle

SH3/SH2 adaptor activity

GTPase activator activity

protein binding

intracellular

cytoplasm

plasma membrane

signal transduction

small GTPase mediated signal transduction

Rho protein signal transduction

SH3 domain binding

Rac GTPase activator activity

regulation of GTPase activity

intracellular membrane-bounded organelle

 
221539_at EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 8 38007176 AB044548 8p12 Hs.411641 107

protein binding

cytosol

eukaryotic initiation factor 4E binding

insulin receptor signaling pathway

negative regulation of translational initiation

ErbB signaling pathway

mTOR signaling pathway

Insulin signaling pathway

Acute myeloid leukemia

209219_at 0.358 7.524 2.283 3.719e-02 0.562 -3.660 RDBP RD RNA binding protein 6 -32027842, -3366126, -3167604 L03411 6p21.3 Hs.423935 34

nucleotide binding

RNA binding

protein binding

nucleus

nucleoplasm

nucleolus

mitochondrion

biological_process

regulation of transcription

 
227194_at FAM3B family with sequence similarity 3, member B 21 41610530 BF106962 21q22.3 Hs.473877 Hs.670704 8

cytokine activity

extracellular region

extracellular space

insulin secretion

 
227713_at KATNAL1 katanin p60 subunit A-like 1 13 -29674766, -29674766 AI807482 13q12.3 Hs.243596 7

nucleotide binding

ATP binding

microtubule

microtubule-severing ATPase activity

hydrolase activity

nucleoside-triphosphatase activity

 
205325_at PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 8 -22133160 NM_014759 8p21.3 Hs.334688 8

protein binding

 
209769_s_at GP1BB glycoprotein Ib (platelet), beta polypeptide 22 18091065 L20860 22q11.21 22q11.21-q11.23 Hs.283743 45

transmembrane receptor activity

protein binding

plasma membrane

integral to plasma membrane

cell adhesion

cell surface receptor linked signal transduction

platelet activation

platelet alpha granule membrane

ECM-receptor interaction

Hematopoietic cell lineage

222722_at OGN osteoglycin 9 -94186069 AV700059 9q22 Hs.109439 24

molecular_function

protein binding

extracellular region

proteinaceous extracellular matrix

endoplasmic reticulum

growth factor activity

biological_process

 
224569_s_at -0.974 9.181 -2.508 2.395e-02 0.509 -3.293 IRF2BP2 interferon regulatory factor 2 binding protein 2 1 -232806637 AW242432 1q42.3 Hs.693837 5

nucleus

regulation of transcription

 
214769_at CLCN4 chloride channel 4 X 10084984 AF052117 Xp22.3 Hs.495674 17

nucleotide binding

ion channel activity

voltage-gated chloride channel activity

ATP binding

endosome

ion transport

chloride transport

antiporter activity

membrane

integral to membrane

chloride ion binding

 
236126_at ACVR2B activin A receptor, type IIB 3 38470793 AI188710 3p22 Hs.174273 38

nucleotide binding

magnesium ion binding

receptor activity

ATP binding

cytoplasm

plasma membrane

integral to plasma membrane

protein amino acid phosphorylation

signal transduction

anterior/posterior pattern formation

cell surface

activin receptor activity, type II

transferase activity

growth factor binding

manganese ion binding

positive regulation of bone mineralization

BMP signaling pathway

BMP signaling pathway

positive regulation of activin receptor signaling pathway

regulation of transcription

positive regulation of osteoblast differentiation

Cytokine-cytokine receptor interaction

TGF-beta signaling pathway

217955_at 0.292 7.972 2.209 4.289e-02 0.576 -3.778 BCL2L13 BCL2-like 13 (apoptosis facilitator) 22 16501484 NM_015367 22q11.1 Hs.631672 12

nucleus

mitochondrion

induction of apoptosis

activation of caspase activity

caspase activator activity

membrane

integral to membrane

regulation of apoptosis

 
224597_at LOC647979 hypothetical LOC647979 20 -34096955 AV729406 20q11.23 Hs.649310 Hs.718413 2    
1554586_a_at RHOBTB2 Rho-related BTB domain containing 2 8 22900874, 22909305, 22913036 BC034917 8p21.3 Hs.372688 18

nucleotide binding

protein binding

GTP binding

intracellular

small GTPase mediated signal transduction

Ubiquitin mediated proteolysis

1554438_at KIAA1217 KIAA1217 10 24023680, 24537725 BC018764 10p12.2-p12.1 Hs.445885 5

molecular_function

cytoplasm

multicellular organismal development

embryonic skeletal system development

 
234684_s_at -0.292 2.616 -3.072 7.640e-03 0.378 -2.327 KRTAP4-4 keratin associated protein 4-4 17 -36569431 AJ296168 17q12-q21 Hs.307022 2

keratin filament

 
225060_at LRP11 low density lipoprotein receptor-related protein 11 6 -150181586 BF696304 6q25.1 Hs.408355 6

receptor activity

membrane

integral to membrane

 
200064_at 0.241 10.780 2.166 4.663e-02 0.582 -3.846 HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 6 44322826 AF275719 6p12 Hs.509736 Hs.689683 Hs.701787 50

nucleotide binding

ATP binding

cytoplasm

protein folding

response to unfolded protein

nitric-oxide synthase regulator activity

TPR domain binding

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

melanosome

positive regulation of nitric oxide biosynthetic process

unfolded protein binding

regulation of interferon-gamma-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway

Antigen processing and presentation

Pathways in cancer

Prostate cancer

211855_s_at SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 X 129301727 AF155810 Xq24 Hs.194686 13

binding

mitochondrion

mitochondrial inner membrane

integral to plasma membrane

transport

mitochondrial transport

aerobic respiration

membrane

 
201784_s_at 0.211 9.168 2.515 2.359e-02 0.508 -3.281 C11orf58 chromosome 11 open reading frame 58 11 16716723 NM_014267 11p15.1 Hs.719128 8

molecular_function

cellular_component

biological_process

 
210373_at TUSC4 tumor suppressor candidate 4 3 -50359922 AF040708 3p21.3 Hs.437083 11

protein kinase activity

protein binding

negative regulation of kinase activity

 
213568_at OSR2 odd-skipped related 2 (Drosophila) 8 100025806 AI811298 8q22.2 Hs.253247 6

nucleic acid binding

intracellular

nucleus

zinc ion binding

positive regulation of cell proliferation

metal ion binding

embryonic skeletal system morphogenesis

 
1552432_at -0.214 5.215 -2.222 4.189e-02 0.574 -3.758 MFSD6L major facilitator superfamily domain containing 6-like 17 -8641205 BC040487 17p13.1 Hs.213603 2

membrane

integral to membrane

 
212612_at RCOR1 REST corepressor 1 14 102128985 D31888 14q32.31 Hs.510521 28

DNA binding

protein binding

nucleus

chromatin modification

interspecies interaction between organisms

regulation of transcription

Huntington's disease

232905_at GTF2H5 general transcription factor IIH, polypeptide 5 6 158509366 AK024874 6q25.3 Hs.356224 11

DNA binding

nucleus

nucleotide-excision repair

response to DNA damage stimulus

regulation of transcription

Nucleotide excision repair

215270_at LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 7 2526004, 2526004 U94354 7p22.2 Hs.159142 11

molecular_function

extracellular region

Golgi apparatus

pattern specification process

organ morphogenesis

membrane

integral to membrane

transferase activity, transferring glycosyl groups

integral to Golgi membrane

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

Notch signaling pathway

223178_s_at NT5DC1 5'-nucleotidase domain containing 1 6 116528691 AF245044 6q22.1 Hs.719198 7

magnesium ion binding

hydrolase activity

 
1561518_at LOC283914 hypothetical protein LOC283914 16 34455287, 34455402 BC038774 16p11.2-p11.1 Hs.385772 1    
1563796_s_at EARS2 glutamyl-tRNA synthetase 2, mitochondrial (putative) 16 -23440834 AK095998 16p12.2 Hs.620541 6

nucleotide binding

RNA binding

glutamate-tRNA ligase activity

ATP binding

cytoplasm

mitochondrion

mitochondrial matrix

glutamyl-tRNA aminoacylation

ligase activity

Porphyrin and chlorophyll metabolism

Aminoacyl-tRNA biosynthesis

Metabolic pathways

207692_s_at -0.243 5.141 -2.219 4.206e-02 0.575 -3.762 ACAN aggrecan 15 87147677 NM_001135 15q26.1 Hs.2159 Hs.616395 Hs.711491 59

skeletal system development

binding

sugar binding

hyaluronic acid binding

extracellular region

proteinaceous extracellular matrix

proteolysis

cell adhesion

extracellular matrix structural constituent conferring compression resistance

extracellular matrix organization

 
228160_at 0.339 6.157 2.326 3.421e-02 0.553 -3.591 LOC339290 hypothetical LOC339290 18 5228098 AI433706 18p11.31 Hs.643553 Hs.700799 4    
1556841_a_at ALDH1L2 aldehyde dehydrogenase 1 family, member L2 12 -103937693 AI378916 12q23.3 Hs.42572 2

acyl carrier activity

cytoplasm

one-carbon metabolic process

methyltransferase activity

biosynthetic process

10-formyltetrahydrofolate catabolic process

formyltetrahydrofolate dehydrogenase activity

oxidoreductase activity

hydroxymethyl-, formyl- and related transferase activity

phosphopantetheine binding

oxidation reduction

 
208572_at HIST3H3 histone cluster 3, H3 1 -226679168 NM_003493 1q42 Hs.248171 73

nucleosome

DNA binding

protein binding

nucleus

chromosome

nucleosome assembly

Systemic lupus erythematosus

219038_at MORC4 MORC family CW-type zinc finger 4 X -106070619 NM_024657 Xq22.3 Hs.496544 5

ATP binding

zinc ion binding

metal ion binding

 
207243_s_at CALM2 calmodulin 2 (phosphorylase kinase, delta) 2 -47240725 NM_001743 2p21 Hs.468442 52  

Calcium signaling pathway

Phosphatidylinositol signaling system

Vascular smooth muscle contraction

Long-term potentiation

Neurotrophin signaling pathway

Olfactory transduction

Insulin signaling pathway

GnRH signaling pathway

Melanogenesis

Alzheimer's disease

Glioma

225810_at MTMR10 myotubularin related protein 10 15 -29018435 AL572015 15q13.3 Hs.30141 Hs.706035 7

dephosphorylation

phosphatase activity

 
225224_at C20orf112 chromosome 20 open reading frame 112 20 -30494522 AL034550 20q11.1-q11.23 Hs.516978 7    
1552524_at -0.349 5.967 -2.339 3.337e-02 0.552 -3.570 ART5 ADP-ribosyltransferase 5 11 -3616311, -3616311 NM_053017 11p15.4 Hs.125680 6

NAD(P)+-protein-arginine ADP-ribosyltransferase activity

extracellular region

protein amino acid ADP-ribosylation

transferase activity, transferring glycosyl groups

 
207817_at IFNW1 interferon, omega 1 9 -21130630 NM_002177 9p22 Hs.73010 14

cytokine activity

cytokine receptor binding

extracellular region

extracellular space

defense response

cell cycle arrest

response to virus

Cytokine-cytokine receptor interaction

RIG-I-like receptor signaling pathway

Jak-STAT signaling pathway

1559977_a_at SLC25A34 solute carrier family 25, member 34 1 15935395 AL832282 1p36.21 Hs.631867 3

binding

mitochondrion

mitochondrial inner membrane

transport

membrane

integral to membrane

 
235958_at PLA2G4F phospholipase A2, group IVF 15 -40220688 AW299828 15q15.1 Hs.231873 6

phospholipase A2 activity

calcium ion binding

cytoplasm

lysosome

cytosol

metabolic process

phospholipid catabolic process

membrane

lipid catabolic process

hydrolase activity

Fc gamma R-mediated phagocytosis

217818_s_at ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 3 9809226 NM_005718 3p25.3 Hs.323342 16

cytoplasm

cytoskeleton

Arp2/3 protein complex

actin filament polymerization

protein binding, bridging

cell projection

actin nucleation

actin filament binding

Fc gamma R-mediated phagocytosis

Regulation of actin cytoskeleton

221047_s_at 0.304 5.486 2.367 3.160e-02 0.544 -3.525 MARK1 MAP/microtubule affinity-regulating kinase 1 1 218768190 NM_018650 1q41 Hs.497806 27

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

ATP binding

cytoplasm

protein amino acid phosphorylation

cytoskeleton organization

protein kinase cascade

microtubule cytoskeleton

transferase activity

 
207853_s_at SNCB synuclein, beta 5 -175979815 NM_003085 5q35 Hs.90297 25

phospholipase inhibitor activity

cytoplasm

mitochondrion

synaptosome

dopamine metabolic process

negative regulation of neuron apoptosis

 
235164_at ZNF25 zinc finger protein 25 10 -38278800 BG433539 10p11.1 Hs.499429 8

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
241983_at PTPN2 protein tyrosine phosphatase, non-receptor type 2 18 -12783246, -12775482, -12775479 AV649337 18p11.3-p11.2 Hs.654527 55

protein tyrosine phosphatase activity

protein binding

cytoplasm

protein amino acid dephosphorylation

hydrolase activity

 
217754_at DDX56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 7 -44571927 NM_019082 7p13 Hs.654762 16

nucleotide binding

RNA binding

ATP-dependent RNA helicase activity

helicase activity

ATP binding

nucleus

nucleolus

rRNA processing

hydrolase activity

identical protein binding

 
221719_s_at LZTS1 leucine zipper, putative tumor suppressor 1 8 -20147956 AF123654 8p22 Hs.521432 11

transcription factor activity

protein binding

nucleus

cytoplasm

Golgi apparatus

plasma membrane

transcription

regulation of transcription, DNA-dependent

cell cycle

postsynaptic density

cell junction

cell projection

dendritic spine

synapse

postsynaptic membrane

 
204467_s_at SNCA synuclein, alpha (non A4 component of amyloid precursor) 4 -90864273, -90864273, -90864273 NM_000345 4q21 Hs.21374 498

positive regulation of receptor recycling

nucleus

cytoplasm

cytosol

plasma membrane

cell cortex

regulation of dopamine secretion

actin cytoskeleton

kinesin binding

axon

growth cone

Hsp70 protein binding

receptor internalization

negative regulation of monooxygenase activity

transferrin transmembrane transporter activity

response to interferon-gamma

negative regulation of histone acetylation

histone binding

alpha-tubulin binding

dynein binding

positive regulation of endocytosis

tau protein binding

synaptic vesicle endocytosis

Alzheimer's disease

Parkinson's disease

221883_at PKNOX1 PBX/knotted 1 homeobox 1 21 43267711 AA133342 21q22.3 Hs.431043 25

angiogenesis

specific RNA polymerase II transcription factor activity

RNA polymerase II transcription factor activity, enhancer binding

protein binding

nucleus

transcription factor complex

cytoplasm

hemopoiesis

T cell differentiation

erythrocyte differentiation

camera-type eye development

sequence-specific DNA binding

positive regulation of transcription from RNA polymerase II promoter

protein heterodimerization activity

 
210368_at PCDHGA8 protocadherin gamma subfamily A, 8 5 140751666, 140751666 AB002325 5q31 Hs.368160 6

calcium ion binding

protein binding

plasma membrane

cell adhesion

homophilic cell adhesion

integral to membrane

 
1558594_at C14orf176 chromosome 14 open reading frame 176 14 20636935 BQ649429 14q11.2    

membrane

integral to membrane

 
202942_at ETFB electron-transfer-flavoprotein, beta polypeptide 19 -56540220, -56540220 NM_001985 19q13.3 Hs.348531 16

mitochondrion

mitochondrial matrix

transport

electron carrier activity

electron transport chain

 
1564537_a_at ASB10 ankyrin repeat and SOCS box-containing 10 7 -150503717, -150503717 AK055536 7q36.1 Hs.647081 6

intracellular signaling cascade

modification-dependent protein catabolic process

 
230069_at SFXN1 sideroflexin 1 5 174838119 BF593817   Hs.369440 18

iron ion binding

protein binding

mitochondrion

mitochondrial inner membrane

cation transport

iron ion transport

cation transmembrane transporter activity

membrane

integral to membrane

erythrocyte differentiation

 
202242_at TSPAN7 tetraspanin 7 X 38305674 NM_004615 Xp11.4 Hs.441664 18

plasma membrane

integral to plasma membrane

protein amino acid N-linked glycosylation

 
204651_at NRF1 nuclear respiratory factor 1 7 129038790, 129057154 AW003022 7q32 Hs.654363 47

DNA binding

nucleus

generation of precursor metabolites and energy

regulation of transcription from RNA polymerase II promoter

regulation of transcription

Huntington's disease

230882_at -0.271 3.380 -2.215 4.240e-02 0.575 -3.768 DLX6AS DLX6 antisense RNA (non-protein coding) 7 -96435763 AA129217 7q21.3 Hs.34969 4    
225693_s_at CAMTA1 calmodulin binding transcription activator 1 1 6767970 AV756867 1p36.31-p36.23 Hs.397705 12

nucleus

cytoplasm

regulation of transcription

 
240070_at TIGIT T cell immunoreceptor with Ig and ITIM domains 3 115495564 AW512550 3q13.31 Hs.421750 4

protein binding

plasma membrane

cell surface

integral to membrane

negative regulation of interleukin-12 production

positive regulation of interleukin-10 production

negative regulation of T cell activation

 
1552726_at ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 15 -98329165 AA022668 15q24 Hs.513200 5

metalloendopeptidase activity

extracellular region

proteinaceous extracellular matrix

proteolysis

peptidase activity

zinc ion binding

metal ion binding

 
224861_at GNAQ guanine nucleotide binding protein (G protein), q polypeptide 9 -79525010 AA628423 9q21 Hs.269782 105

nucleotide binding

skeletal system development

regulation of action potential

GTPase activity

signal transducer activity

protein binding

GTP binding

membrane fraction

cytoplasm

plasma membrane

plasma membrane

protein amino acid ADP-ribosylation

signal transduction

G-protein coupled receptor protein signaling pathway

activation of adenylate cyclase activity by G-protein signaling pathway

activation of phospholipase C activity

glutamate signaling pathway

heart development

blood coagulation

behavior

post-embryonic development

neuron remodeling

guanyl nucleotide binding

forebrain neuron development

embryonic digit morphogenesis

regulation of melanocyte differentiation

pigmentation during development

activation of phospholipase C activity by dopamine receptor signaling pathway

Calcium signaling pathway

Vascular smooth muscle contraction

Gap junction

Long-term potentiation

Long-term depression

GnRH signaling pathway

Melanogenesis

Alzheimer's disease

Huntington's disease

208677_s_at BSG basigin (Ok blood group) 19 522324, 523536 AL550657 19p13.3 Hs.501293 124

Golgi membrane

protein binding

sugar binding

mannose binding

plasma membrane

plasma membrane

cell surface receptor linked signal transduction

integral to membrane

melanosome

 
225740_x_at MDM4 Mdm4 p53 binding protein homolog (mouse) 1 202752133 AA961420 1q32 Hs.497492 68

negative regulation of transcription from RNA polymerase II promoter

protein binding

intracellular

nucleus

protein complex assembly

apoptosis

zinc ion binding

negative regulation of cell proliferation

negative regulation of protein catabolic process

G0 to G1 transition

metal ion binding

protein stabilization

p53 signaling pathway

233164_x_at RHBDD1 rhomboid domain containing 1 2 227409016 AK026955 2q36.3 Hs.471514 7

peptidase activity

serine-type peptidase activity

membrane

integral to membrane

 
210015_s_at -0.283 3.338 -2.817 1.288e-02 0.432 -2.771 MAP2 microtubule-associated protein 2 2 209997015, 210152647 U89330 2q34-q35 Hs.368281 58

structural molecule activity

calmodulin binding

cytoplasm

cytoskeleton

microtubule

microtubule associated complex

negative regulation of microtubule depolymerization

 
239173_at INADL InaD-like (Drosophila) 1 61980736 AI697184 1p31.3 Hs.478125 24

protein binding

cellular_component

plasma membrane

tight junction

intracellular signaling cascade

apical plasma membrane

cell junction

Tight junction

222133_s_at PHF20L1 PHD finger protein 20-like 1 8 133856785, 133856785, 133856785 AK022280 8q24.22 Hs.304362 4

nucleic acid binding

protein binding

zinc ion binding

metal ion binding

 
218821_at NPEPL1 aminopeptidase-like 1 20 56701267 AL139349 20q13.32 Hs.554211 Hs.654868 7

aminopeptidase activity

intracellular

proteolysis

peptidase activity

zinc ion binding

manganese ion binding

metal ion binding

 
1566140_at HOPX HOP homeobox 4 -57208910, -57208910 AK096707 4q11-q12 Hs.654864 25

negative regulation of transcription from RNA polymerase II promoter

trophectodermal cell differentiation

transcription factor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

heart development

regulation of heart contraction

transcription repressor activity

histone deacetylation

positive regulation of skeletal muscle regeneration

sequence-specific DNA binding

negative regulation of cell differentiation

lung alveolus development

positive regulation of striated muscle cell differentiation

 
211628_x_at FTHP1 ferritin, heavy polypeptide pseudogene 1 6   J04755 6p21.3-p12 Hs.453583 1    
221289_at DLX6 distal-less homeobox 6 7 96473225 NM_005222 7q22 Hs.249196 11

skeletal system development

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

nervous system development

embryonic limb morphogenesis

epithelial cell differentiation

inner ear morphogenesis

sequence-specific DNA binding

anatomical structure formation involved in morphogenesis

positive regulation of epithelial cell proliferation

 
211673_s_at MOCS1 molybdenum cofactor synthesis 1 6 -39980023, -39980023 AF034374 6p21.3 Hs.718492 19

nucleotide binding

catalytic activity

iron ion binding

GTP binding

nucleus

Mo-molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

metabolic process

molybdopterin synthase complex

molybdenum ion binding

metal ion binding

4 iron, 4 sulfur cluster binding

 
207660_at -0.687 4.226 -4.479 4.270e-04 0.193 0.114 DMD dystrophin X -31106232, -31047265, -31047265, -31047265, -31047265, -31047265, -31047265, -31047265, -31047265, -31047265 NM_004019 Xp21.2 Hs.495912 240

actin binding

structural constituent of cytoskeleton

calcium ion binding

protein binding

cytoplasm

cytoskeleton

muscle organ development

zinc ion binding

structural constituent of muscle

structural constituent of muscle

cell surface

dystrophin-associated glycoprotein complex

sarcolemma

costamere

peptide biosynthetic process

nitric-oxide synthase binding

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

216399_s_at SCAPER S-phase cyclin A-associated protein in the ER 15 -74427583, -74427583 AK025663 15q24 Hs.458986 7

intracellular

nucleus

endoplasmic reticulum

zinc ion binding

metal ion binding

 
1552695_a_at -0.351 4.130 -2.516 2.358e-02 0.508 -3.280 SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 12 -38435091 NM_052885 12q12 Hs.558595 5

transporter activity

membrane

integral to membrane

substrate-specific transmembrane transporter activity

transmembrane transport

 
205595_at DSG3 desmoglein 3 (pemphigus vulgaris antigen) 18 27281729 NM_001944 18q12.1-q12.2 Hs.1925 51

calcium ion binding

protein binding

cytosol

plasma membrane

plasma membrane

cell adhesion

homophilic cell adhesion

integral to membrane

cell junction

desmosome

 
1559292_s_at NCRNA00032 non-protein coding RNA 32 9 -27235683 AF507950 9p21 Hs.201554 1    
200876_s_at PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 6 -170686129 NM_002793 6q27 Hs.352768 47

threonine-type endopeptidase activity

protein binding

nucleus

cytoplasm

cytosol

proteasome core complex

peptidase activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

proteolysis involved in cellular protein catabolic process

Proteasome

219327_s_at GPRC5C G protein-coupled receptor, family C, group 5, member C 17 69939261, 69941430 NM_022036 17q25 Hs.446438 10

receptor activity

G-protein coupled receptor activity

protein binding

mitochondrion

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

cytoplasmic vesicle

 
225953_at RPRD1A regulation of nuclear pre-mRNA domain containing 1A 18 -31823789 AI684281 18q12.2 Hs.464912 3    
236726_at RGS6 regulator of G-protein signaling 6 14 71469538 H41121 14q24.3 Hs.509872 13

signal transducer activity

GTPase activator activity

cellular_component

cytoplasm

heterotrimeric G-protein complex

intracellular signaling cascade

regulation of G-protein coupled receptor protein signaling pathway

negative regulation of signal transduction

membrane

 
244071_at FBLL1 fibrillarin-like 1 5 167889159 AA868464 5q34 Hs.166262  

RNA binding

nucleus

nucleolus

rRNA processing

methyltransferase activity

transferase activity

ribonucleoprotein complex

 
217831_s_at NSFL1C NSFL1 (p97) cofactor (p47) 20 -1370810 NM_016143 20p13 Hs.12865 20

protein binding

nucleus

Golgi apparatus

Golgi stack

lipid binding

 
211748_x_at PTGDS prostaglandin D2 synthase 21kDa (brain) 9 138991776 BC005939 9q34.2-q34.3 Hs.446429 63

prostaglandin biosynthetic process

prostaglandin-D synthase activity

transporter activity

binding

retinoid binding

extracellular region

nucleus

cytoplasm

rough endoplasmic reticulum

Golgi apparatus

fatty acid biosynthetic process

transport

membrane

isomerase activity

nuclear membrane

regulation of circadian sleep/wake cycle, sleep

perinuclear region of cytoplasm

Arachidonic acid metabolism

Metabolic pathways

206801_at NPPB natriuretic peptide precursor B 1 -11840107 NM_002521 1p36.2 Hs.219140 228

extracellular region

extracellular space

cell surface receptor linked signal transduction

regulation of blood pressure

diuretic hormone activity

negative regulation of angiogenesis

diuresis

natriuresis

negative regulation of cell growth

regulation of vasodilation

regulation of vascular permeability

regulation of blood vessel size

 
218937_at ZNF434 zinc finger protein 434 16 -3372085 NM_017810 16p13.3 Hs.592078 3

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
208328_s_at MEF2A myocyte enhancer factor 2A 15 97923655, 97990705 NM_005587 15q26 Hs.268675 77

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

apoptosis

multicellular organismal development

nervous system development

muscle organ development

cell differentiation

sequence-specific DNA binding

 
210266_s_at 0.337 7.708 2.438 2.749e-02 0.526 -3.409 TRIM33 tripartite motif-containing 33 1 -114736921 AF220137 1p13.1 Hs.26837 12

DNA binding

protein binding

intracellular

nucleus

zinc ion binding

negative regulation of transcription

protein ubiquitination

ligase activity

regulation of transforming growth factor beta receptor signaling pathway

modification-dependent protein catabolic process

negative regulation of BMP signaling pathway

metal ion binding

co-SMAD binding

R-SMAD binding

 
222522_x_at MRPS10 mitochondrial ribosomal protein S10 6 -42282516 BG393476 6p21.1 Hs.380887 Hs.669022 8

molecular_function

structural constituent of ribosome

intracellular

mitochondrion

ribosome

translation

biological_process

 
213358_at KIAA0802 KIAA0802 18 8707368 AB018345 18p11.22 Hs.650822 10    
211285_s_at UBE3A ubiquitin protein ligase E3A 15 -23133488, -23133488, -23133488 U84404 15q11-q13 Hs.598862 76

ubiquitin-protein ligase activity

protein binding

intracellular

nucleus

cytosol

protein modification process

proteolysis

ubiquitin-dependent protein catabolic process

brain development

protein ubiquitination

ligase activity

acid-amino acid ligase activity

protein complex

interspecies interaction between organisms

Ubiquitin mediated proteolysis

218499_at RP6-213H19.1 serine/threonine protein kinase MST4 X 130984925, 130985316 NM_016542 Xq26.2 Hs.444247 16

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

ATP binding

cytoplasm

Golgi apparatus

protein amino acid phosphorylation

transferase activity

identical protein binding

regulation of apoptosis

 
225611_at MAST4 microtubule associated serine/threonine kinase family member 4 5 65927931, 66160359 AI922968 5q12.3 Hs.595458 5

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

protein amino acid phosphorylation

transferase activity

 
227792_at 0.317 7.361 2.539 2.250e-02 0.500 -3.241 ITPRIPL2 inositol 1,4,5-triphosphate receptor interacting protein-like 2 16 19032754 AA490685 16p12.3 Hs.530899 Hs.648523 3

membrane

integral to membrane

 
217710_x_at ITPK1 inositol 1,3,4-triphosphate 5/6 kinase 14 -92475821, -92473011 AI075181 14q31 Hs.308122 12

nucleotide binding

magnesium ion binding

ATP binding

intracellular

signal transduction

kinase activity

transferase activity

hydrolase activity

isomerase activity

inositol trisphosphate metabolic process

inositol-1,3,4-trisphosphate 5/6-kinase activity

inositol tetrakisphosphate 1-kinase activity

Inositol phosphate metabolism

Metabolic pathways

Phosphatidylinositol signaling system

218728_s_at CNIH4 cornichon homolog 4 (Drosophila) 1 222611217 NM_014184 1q42.11 Hs.195403 Hs.445890 11

protein binding

endoplasmic reticulum

intracellular signaling cascade

membrane

integral to membrane

 
219039_at SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 2 -96889199 NM_017789 2q11.2 Hs.516220 9

receptor activity

protein binding

multicellular organismal development

nervous system development

membrane

integral to membrane

cell differentiation

Axon guidance

238320_at NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding) 11 64946844, 64946844 AV659198 11q13.1 Hs.523789 Hs.648467 6    
213512_at C14orf79 chromosome 14 open reading frame 79 14 104523660 BF109941 14q32.33 Hs.27183 7    
217607_x_at EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 11 -10775168 AA733172 11p15 Hs.183684 39

translation initiation factor activity

protein binding

regulation of translational initiation

cell cycle arrest

cell death

RNA metabolic process

eukaryotic translation initiation factor 4F complex

 
231967_at PHF20L1 PHD finger protein 20-like 1 8 133856785, 133856785, 133856785 AI913146 8q24.22 Hs.304362 4

nucleic acid binding

protein binding

zinc ion binding

metal ion binding

 
222587_s_at GALNT7 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) 4 174326478 BF699855 4q31.1 Hs.548088 7

polypeptide N-acetylgalactosaminyltransferase activity

calcium ion binding

sugar binding

Golgi apparatus

carbohydrate metabolic process

protein amino acid O-linked glycosylation

membrane

integral to membrane

transferase activity, transferring glycosyl groups

manganese ion binding

O-Glycan biosynthesis

Metabolic pathways

219714_s_at CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 3 54131732 NM_018398 3p21.1 Hs.656687 9

voltage-gated ion channel activity

calcium channel activity

calcium ion binding

ion transport

calcium ion transport

membrane

integral to membrane

MAPK signaling pathway

Cardiac muscle contraction

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

210251_s_at RUFY3 RUN and FYVE domain containing 3 4 71789517, 71806559, 71806559 AF112221 4q13.3 Hs.713172 8

multicellular organismal development

nervous system development

cell differentiation

filopodium

growth cone

negative regulation of axonogenesis

 
219699_at LGI2 leucine-rich repeat LGI family, member 2 4 -24609568 NM_018176 4p15.2 Hs.12488 11

protein binding

extracellular region

 
211184_s_at -0.257 4.467 -2.404 2.941e-02 0.536 -3.465 USH1C Usher syndrome 1C (autosomal recessive, severe) 11 -17472018 AB006955 11p15.1-p14 Hs.502072 32

G2/M transition of mitotic cell cycle

protein binding

cytoplasm

sensory perception of sound

stereocilium

apical part of cell

photoreceptor cell maintenance

response to stimulus

equilibrioception

 
207929_at GRPR gastrin-releasing peptide receptor X 16051344 NM_005314 Xp22.2-p22.13 Hs.567282 36

receptor activity

bombesin receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

peptide receptor activity, G-protein coupled

regulation of cell proliferation

Calcium signaling pathway

Neuroactive ligand-receptor interaction

213258_at 0.655 7.151 3.785 1.758e-03 0.268 -1.078 TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2 -188051550, -188037202 BF511231 2q32 Hs.516578 118

serine-type endopeptidase inhibitor activity

extracellular region

extracellular region

extracellular space

plasma membrane

blood coagulation, extrinsic pathway

Complement and coagulation cascades

223899_at PBRM1 polybromo 1 3 -52554407, -52554407 AF225870 3p21 Hs.189920 19

nuclear chromosome

DNA binding

chromatin binding

protein binding

nucleus

chromatin remodeling

mitosis

regulation of transcription

 
227954_at ITPRIPL2 inositol 1,4,5-triphosphate receptor interacting protein-like 2 16 19032754 AI458417 16p12.3 Hs.530899 Hs.648523 3

membrane

integral to membrane

 
201200_at 0.560 8.802 2.955 9.722e-03 0.407 -2.532 CREG1 cellular repressor of E1A-stimulated genes 1 1 -165776874 NM_003851 1q24 Hs.5710 16

RNA polymerase II transcription factor activity

transcription corepressor activity

extracellular region

regulation of transcription from RNA polymerase II promoter

multicellular organismal development

cell proliferation

regulation of growth

 
201587_s_at 0.535 7.863 2.619 1.920e-02 0.489 -3.108 IRAK1 interleukin-1 receptor-associated kinase 1 X -152929150 NM_001569 Xq28 Hs.522819 107

nucleotide binding

magnesium ion binding

regulation of cytokine-mediated signaling pathway

MyD88-dependent toll-like receptor signaling pathway

protein serine/threonine kinase activity

NF-kappaB-inducing kinase activity

ATP binding

cytosol

signal transduction

transmembrane receptor protein serine/threonine kinase signaling pathway

activation of NF-kappaB-inducing kinase activity

transcription activator activity

transferase activity

lipopolysaccharide-mediated signaling pathway

negative regulation of NF-kappaB transcription factor activity

response to lipopolysaccharide

toll-like receptor 2 signaling pathway

protein homodimerization activity

interleukin-1 receptor complex

positive regulation of transcription

protein amino acid autophosphorylation

protein heterodimerization activity

positive regulation of NF-kappaB transcription factor activity

protein oligomerization

interleukin-1-mediated signaling pathway

response to interleukin-1

Apoptosis

Toll-like receptor signaling pathway

Neurotrophin signaling pathway

224998_at 0.248 5.929 2.466 2.600e-02 0.518 -3.362 CMTM4 CKLF-like MARVEL transmembrane domain containing 4 16 -65206153 AK000855 16q21-q22.1 Hs.643961 3

cytokine activity

extracellular space

chemotaxis

membrane

integral to membrane

 
208643_s_at XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 2 216682264 J04977 2q35 Hs.388739 148

nucleotide binding

telomere maintenance

nuclear telomere cap complex

DNA binding

double-stranded telomeric DNA binding

ATP-dependent DNA helicase activity

helicase activity

ATP binding

nucleus

nucleoplasm

chromosome

double-strand break repair via nonhomologous end joining

response to DNA damage stimulus

protein C-terminus binding

promoter binding

hydrolase activity

provirus integration

initiation of viral infection

Non-homologous end-joining

228494_at PPP1R9A protein phosphatase 1, regulatory (inhibitor) subunit 9A 7 94374884 AI888150 7q21.3 Hs.21816 12

actin binding

protein binding

cytoplasm

cytoskeleton

actin filament organization

multicellular organismal development

nervous system development

synaptosome

cell junction

cell differentiation

filopodium

cortical actin cytoskeleton

dendritic spine

synapse

 
240878_at SPEM1 spermatid maturation 1 17 7264402 AW172597 17p13.1 Hs.710599 3

cytoplasm

multicellular organismal development

spermatogenesis

membrane

integral to membrane

cell differentiation

 
208119_s_at ZNF93 zinc finger protein 93 19 19872786 NM_031218 19p12 Hs.301059 5

transcription factor activity

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
210583_at -0.212 5.302 -2.177 4.558e-02 0.581 -3.828 POLDIP3 polymerase (DNA-directed), delta interacting protein 3 22 -41309670 AB055760 22q13.2 Hs.505802 11

nucleotide binding

RNA binding

protein binding

nucleus

 
234511_at ANKRD60 ankyrin repeat domain 60 20   AL354776 20q13.32   1    
210331_at HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 7 43118722 AB048365 7p14.1-p13 Hs.164453 8

protein binding

intracellular

cytoplasm

protein modification process

ligase activity

acid-amino acid ligase activity

modification-dependent protein catabolic process

 
226982_at 0.490 5.535 2.312 3.516e-02 0.555 -3.614 ELL2 elongation factor, RNA polymerase II, 2 5 -95246557 AI745624 5q15 Hs.192221 Hs.708710 6

RNA polymerase II transcription factor activity

nucleus

RNA elongation from RNA polymerase II promoter

transcription elongation factor complex

RNA polymerase II transcription elongation factor activity

regulation of transcription

 
203656_at FIG4 FIG4 homolog (S. cerevisiae) 6 110119116 NM_014845 6q21 Hs.529959 14

protein binding

endosome

cell death

endosome membrane

membrane

hydrolase activity

 
232293_at LCORL ligand dependent nuclear receptor corepressor-like 4 -17453941 AL133031 4p15.31 Hs.446201 Hs.661849 Hs.677572 9

DNA binding

RNA polymerase II transcription factor activity

nucleus

transcription from RNA polymerase II promoter

regulation of transcription

 
213037_x_at STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) 20 -47163282 AJ132258 20q13.1 Hs.596704 26

double-stranded RNA binding

protein binding

intracellular

rough endoplasmic reticulum

microtubule associated complex

intracellular mRNA localization

ribonucleoprotein complex

 
201992_s_at KIF5B kinesin family member 5B 10 -32337943 NM_004521 10pter-q22.1 Hs.644646 36

nucleotide binding

microtubule motor activity

protein binding

ATP binding

cytoplasm

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

cytoplasm organization

microtubule binding

ciliary rootlet

neuron projection

membrane-bounded organelle

vesicle transport along microtubule

perinuclear region of cytoplasm

 
223139_s_at DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 3 -155476150 BE501133 3p13-q23 Hs.446270 13

nucleotide binding

nucleic acid binding

helicase activity

protein binding

ATP binding

nucleus

cytoplasm

ATP-dependent helicase activity

hydrolase activity

 
225589_at SH3RF1 SH3 domain containing ring finger 1 4 -170251981 AB040927 4q32.3-q33 Hs.301804 9

protein binding

cytoplasm

Golgi apparatus

zinc ion binding

ligase activity

lamellipodium

metal ion binding

perinuclear region of cytoplasm

 
211198_s_at ICOSLG inducible T-cell co-stimulator ligand 21 -44471149 AF289028 21q22.3 Hs.14155 29

receptor binding

defense response

immune response

hyperosmotic response

signal transduction

membrane

integral to membrane

positive regulation of activated T cell proliferation

T cell activation

B cell activation

Cell adhesion molecules (CAMs)

224657_at ERRFI1 ERBB receptor feedback inhibitor 1 1 -7994366 AL034417 1p36 Hs.605445 26

Rho GTPase activator activity

protein binding

cytoplasm

response to stress

 
212973_at -0.173 8.276 -2.222 4.189e-02 0.574 -3.758 RPIA ribose 5-phosphate isomerase A 2 88772290 AI692341 2p11.2 Hs.469264 7

ribose-5-phosphate isomerase activity

ribose-5-phosphate isomerase activity

intracellular

cytosol

pentose-phosphate shunt, non-oxidative branch

isomerase activity

Pentose phosphate pathway

Carbon fixation in photosynthetic organisms

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of plant hormones

Metabolic pathways

206218_at MAGEB2 melanoma antigen family B, 2 X 30143595 NM_002364 Xp21.3 Hs.113824 12

protein binding

 
211370_s_at 0.487 6.224 2.517 2.349e-02 0.507 -3.277 MAP2K5 mitogen-activated protein kinase kinase 5 15 65622074 U71088 15q23 Hs.114198 29

MAPKKK cascade

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein tyrosine kinase activity

protein binding

ATP binding

spindle

protein amino acid phosphorylation

signal transduction

heart development

transferase activity

MAPK signaling pathway

Gap junction

Neurotrophin signaling pathway

206698_at XK X-linked Kx blood group (McLeod syndrome) X 37430051 NM_021083 Xp21.1 Hs.78919 24

transporter activity

protein binding

transport

amino acid transport

membrane

integral to membrane

 
233188_at GALNTL4 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4 11 -11248996 AF131852 11p15.3 Hs.655152 6

polypeptide N-acetylgalactosaminyltransferase activity

calcium ion binding

sugar binding

Golgi apparatus

membrane

integral to membrane

transferase activity, transferring glycosyl groups

manganese ion binding

O-Glycan biosynthesis

Metabolic pathways

221571_at TRAF3 TNF receptor-associated factor 3 14 102313568 AI721219 14q32.32 Hs.510528 99

signal transducer activity

protein binding

cytoplasm

induction of apoptosis

signal transduction

zinc ion binding

regulation of apoptosis

metal ion binding

Toll-like receptor signaling pathway

RIG-I-like receptor signaling pathway

Pathways in cancer

Small cell lung cancer

211844_s_at NRP2 neuropilin 2 2 206255468, 206255468, 206255468 AF022859 2q33.3 Hs.471200 44

receptor activity

vascular endothelial growth factor receptor activity

membrane fraction

plasma membrane

cell adhesion

multicellular organismal development

nervous system development

axon guidance

integral to membrane

cell differentiation

 
241727_x_at DHFRL1 dihydrofolate reductase-like 1 3 -95259455 AA578546 3q11.1 Hs.718516 4

dihydrofolate reductase activity

glycine biosynthetic process

nucleotide biosynthetic process

NADP or NADPH binding

 
212681_at 0.792 4.830 2.195 4.411e-02 0.579 -3.801 EPB41L3 erythrocyte membrane protein band 4.1-like 3 18 -5382387 AI770004 18p11.32 Hs.213394 39

actin binding

structural molecule activity

cytoplasm

cytoskeleton

plasma membrane

cell-cell junction

biological_process

extrinsic to membrane

cortical actin cytoskeleton organization

Tight junction

219922_s_at LTBP3 latent transforming growth factor beta binding protein 3 11 -65062605 NM_021070 11q13.1 Hs.289019 19

binding

calcium ion binding

extracellular region

growth factor binding

 
206843_at CRYBA4 crystallin, beta A4 22 25347927 NM_001886 22q11.2-q13.1 22q12.1 Hs.57690 13

molecular_function

structural constituent of eye lens

soluble fraction

visual perception

visual perception

camera-type eye development

 
1556049_at RTN4 reticulon 4 2 -55052830, -55052830, -55052830 CA428769 2p16.3 Hs.704007 73

protein binding

nuclear envelope

endoplasmic reticulum

membrane

integral to membrane

negative regulation of anti-apoptosis

integral to endoplasmic reticulum membrane

regulation of cell migration

negative regulation of axon extension

regulation of apoptosis

 
217945_at BTBD1 BTB (POZ) domain containing 1 15 -81476184 NM_025238 15q24 Hs.459149 15

cytoplasmic mRNA processing body

protein binding

cellular_component

cytoplasm

biological_process

modification-dependent protein catabolic process

protein complex

 
227768_at ZNF407 zinc finger protein 407 18 70471906, 70471906, 70471906 AB051490 18q23 Hs.536490 3

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
226999_at RNPC3 RNA-binding region (RNP1, RRM) containing 3 1 103841165 AL137730 1p21 Hs.632423 Hs.632430 7

nucleotide binding

RNA binding

nucleus

U12-type spliceosomal complex

mRNA processing

RNA splicing

 
1569323_at PTPRG protein tyrosine phosphatase, receptor type, G 3 61522282 BU853579 3p21-p14 Hs.595541 Hs.654488 19

transmembrane receptor protein tyrosine phosphatase activity

integral to plasma membrane

protein amino acid dephosphorylation

transmembrane receptor protein tyrosine kinase signaling pathway

membrane

hydrolase activity

identical protein binding

 
209265_s_at METTL3 methyltransferase like 3 14 -21036121 BC001650 14q11.1 Hs.168799 8

RNA methylation

RNA binding

nucleus

nucleoplasm

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

methyltransferase activity

mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity

nuclear speck

transferase activity

 
1561355_at LOC692247 hypothetical locus LOC692247 11   AA975897 11p15.5 Hs.560022 2    
1556072_at C22orf37 chromosome 22 open reading frame 37 22   AK097861 22q11.21 Hs.517397 1    
215938_s_at PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 22 -36837447 AK001290 22q13.1 Hs.170479 48

nucleus

cytoplasm

centrosome

phospholipid metabolic process

metabolic process

cell death

membrane

lipid catabolic process

hydrolase activity

calcium-independent phospholipase A2 activity

Glycerophospholipid metabolism

Ether lipid metabolism

Arachidonic acid metabolism

Linoleic acid metabolism

alpha-Linolenic acid metabolism

Metabolic pathways

MAPK signaling pathway

Vascular smooth muscle contraction

VEGF signaling pathway

Fc epsilon RI signaling pathway

Fc gamma R-mediated phagocytosis

Long-term depression

GnRH signaling pathway

1554994_at -0.249 2.521 -2.170 4.624e-02 0.582 -3.840 RAG1 recombination activating gene 1 11 36546138 BC037344 11p13 Hs.677010 Hs.73958 58

DNA binding

endonuclease activity

protein binding

intracellular

nucleus

DNA recombination

immune response

zinc ion binding

death

hydrolase activity

B cell differentiation

T cell differentiation in the thymus

V(D)J recombination

negative regulation of caspase activity

metal ion binding

negative regulation of thymocyte apoptosis

Primary immunodeficiency

227405_s_at FZD8 frizzled homolog 8 (Drosophila) 10 -35967182 AW340311 10p11.21 Hs.302634 14

non-G-protein coupled 7TM receptor activity

G-protein coupled receptor activity

G-protein coupled receptor protein signaling pathway

multicellular organismal development

membrane

integral to membrane

Wnt receptor signaling pathway

Wnt-protein binding

Wnt receptor activity

Wnt signaling pathway

Melanogenesis

Pathways in cancer

Colorectal cancer

Basal cell carcinoma

202578_s_at DDX19A DEAD (Asp-Glu-Ala-As) box polypeptide 19A 16 68938324 NM_018332 16q22.1 Hs.656037 5

nucleotide binding

RNA binding

helicase activity

ATP binding

nucleus

nuclear pore

cytoplasm

ATP-dependent helicase activity

protein transport

membrane

hydrolase activity

mRNA transport

intracellular protein transmembrane transport

 
216511_s_at 0.275 5.301 2.612 1.945e-02 0.489 -3.119 TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 10 114699998 AJ270770 10q25.3 Hs.593995 246

blood vessel development

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

regulation of transcription from RNA polymerase II promoter

anti-apoptosis

cell cycle arrest

beta-catenin binding

transcription factor binding

cell proliferation

positive regulation of specific transcription from RNA polymerase II promoter

positive regulation of heparan sulfate proteoglycan biosynthetic process

specific transcriptional repressor activity

protein kinase binding

pancreas development

positive regulation of insulin secretion

regulation of hormone metabolic process

glucose homeostasis

fat cell differentiation

regulation of transcription

myoblast cell fate commitment

Wnt receptor signaling pathway through beta-catenin

beta-catenin-TCF7L2 complex

Wnt signaling pathway

Adherens junction

Melanogenesis

Pathways in cancer

Colorectal cancer

Endometrial cancer

Prostate cancer

Thyroid cancer

Basal cell carcinoma

Acute myeloid leukemia

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

213906_at MYBL1 v-myb myeloblastosis viral oncogene homolog (avian)-like 1 8 -67636963 AW592266 8q22 Hs.445898 8

DNA binding

nucleus

nucleolus

regulation of transcription, DNA-dependent

transcription activator activity

 
222561_at LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 7 55400634 AJ278245 7q31.1-q31.33 Hs.595384 Hs.655117 9

catalytic activity

ATP binding

GTP binding

nucleus

cytoplasm

cytosol

plasma membrane

negative regulation of transcription

 
235908_at MMP11 matrix metallopeptidase 11 (stromelysin 3) 22 22445035 AW511464 22q11.2 22q11.23 Hs.143751 30

metalloendopeptidase activity

calcium ion binding

extracellular region

proteinaceous extracellular matrix

proteolysis

multicellular organismal development

peptidase activity

zinc ion binding

collagen catabolic process

 
228298_at -0.301 4.394 -2.799 1.334e-02 0.435 -2.800 FAM113B family with sequence similarity 113, member B 12 45896318 BF056901 12q13.11 Hs.560100 1    
214574_x_at LST1 leukocyte specific transcript 1 6 31661949, 31662603, 3000093, 3000747, 2801557, 2802211 NM_007161 6p21.3 Hs.436066 20

cell morphogenesis

molecular_function

protein binding

cytoplasm

Golgi apparatus

immune response

regulation of cell shape

anatomical structure morphogenesis

membrane

integral to membrane

dendrite development

negative regulation of lymphocyte proliferation

 
204706_at -0.283 6.578 -2.586 2.051e-02 0.496 -3.163 INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 9 -138442892 NM_019892 9q34.3 Hs.120998 5

Golgi membrane

inositol or phosphatidylinositol phosphatase activity

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

inositol-polyphosphate 5-phosphatase activity

cellular_component

Golgi apparatus

lipid metabolic process

biological_process

membrane

hydrolase activity

Inositol phosphate metabolism

Metabolic pathways

Phosphatidylinositol signaling system

220266_s_at KLF4 Kruppel-like factor 4 (gut) 9 -109286953 NM_004235 9q31 Hs.376206 66

transcription factor activity

intracellular

nucleus

nucleolus

mesodermal cell fate determination

zinc ion binding

negative regulation of cell proliferation

transcription activator activity

transcription repressor activity

regulation of transcription

negative regulation of transcription, DNA-dependent

metal ion binding

 
1563405_at ATP4B ATPase, H+/K+ exchanging, beta polypeptide 13 -113351122 BC042846 13q34 Hs.434202 17

sodium:potassium-exchanging ATPase activity

ATP biosynthetic process

ion transport

potassium ion transport

sodium ion transport

hydrogen:potassium-exchanging ATPase activity

proton transport

membrane

integral to membrane

potassium ion binding

Oxidative phosphorylation

216129_at ATP9A ATPase, class II, type 9A 20 -49646720 AL117659 20q13.2 Hs.719117 6

nucleotide binding

magnesium ion binding

phospholipid-translocating ATPase activity

ATP binding

ATP biosynthetic process

metabolic process

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

phospholipid transport

membrane

integral to membrane

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

 
216838_at LOC92249 hypothetical LOC92249 X -62563163 AK023798 Xq11.1 Hs.31532 Hs.708316 1    
226502_at ELMOD2 ELMO/CED-12 domain containing 2 4 141664801 BG477315 4q31.1 Hs.450105 6

cytoskeleton

phagocytosis

 
239493_at RPL7 ribosomal protein L7 8 -74365427 AI984074 8q21.11 Hs.421257 Hs.571841 23

DNA binding

mRNA binding

structural constituent of ribosome

intracellular

cytosol

ribosome

rRNA processing

translational elongation

cytosolic large ribosomal subunit

transcription regulator activity

ribosomal large subunit biogenesis

protein homodimerization activity

Ribosome

209723_at SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 6 -2832504 BC002538 6p25 Hs.104879 27

serine-type endopeptidase inhibitor activity

protein binding

cytoplasm

cytosol

anti-apoptosis

signal transduction

peptidase inhibitor activity

 
223518_at DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 1 -10443189 AF087573 1p36.3-p36.2 Hs.484782 44

caspase-activated deoxyribonuclease activity

intracellular

nucleus

nucleoplasm

cytoplasm

cytosol

DNA fragmentation involved in apoptosis

intracellular signaling cascade

identical protein binding

negative regulation of apoptosis

Apoptosis

203232_s_at ATXN1 ataxin 1 6 -16407321 NM_000332 6p23 Hs.434961 Hs.712106 65

RNA binding

nucleus

nucleoplasm

nucleolus

cytoplasm

RNA processing

protein C-terminus binding

cell death

poly(U) RNA binding

adult locomotory behavior

visual learning

nuclear matrix

negative regulation of transcription

transcription repressor activity

poly(G) RNA binding

nuclear RNA export factor complex

negative regulation of phosphorylation

nuclear inclusion body

identical protein binding

negative regulation of insulin-like growth factor receptor signaling pathway

protein self-association

positive regulation of transcription from RNA polymerase II promoter

nuclear export

regulation of excitatory postsynaptic membrane potential

 
227863_at 0.536 4.685 2.521 2.335e-02 0.507 -3.272 CTSD cathepsin D 11 -1730560 AV706254 11p15.5 Hs.121575 Hs.654447 140

autophagic vacuole formation

aspartic-type endopeptidase activity

extracellular region

mitochondrion

lysosome

proteolysis

peptidase activity

melanosome

Lysosome

216699_s_at KLK1 kallikrein 1 19 -56014215 L10038 19q13.3 Hs.123107 74

serine-type endopeptidase activity

proteolysis

peptidase activity

 
211121_s_at DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 2 74635367 AF180527 2p13 Hs.103854 52

insulin receptor binding

protein binding

cell surface receptor linked signal transduction

transmembrane receptor protein tyrosine kinase signaling pathway

 
204856_at B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 19 17766918 NM_014256 19p13.1 Hs.657825 Hs.69009 13

Golgi apparatus

integral to plasma membrane

protein amino acid glycosylation

galactosyltransferase activity

membrane

transferase activity, transferring glycosyl groups

Glycosphingolipid biosynthesis - lacto and neolacto series

Metabolic pathways

232316_at C14orf174 chromosome 14 open reading frame 174 14 76913514 AA972465 14q24.3 Hs.421961 4    
212573_at ENDOD1 endonuclease domain containing 1 11 94462664 AF131747 11q21 Hs.167115 6

nucleic acid binding

endonuclease activity

extracellular region

hydrolase activity

metal ion binding

Apoptosis

202583_s_at RANBP9 RAN binding protein 9 6 -13729708 NM_005493 6p23 Hs.708182 37

nucleus

cytoplasm

microtubule associated complex

protein complex assembly

microtubule nucleation

Ran GTPase binding

enzyme binding

 
1558875_at SREBF1 sterol regulatory element binding transcription factor 1 17 -17656110 S66168 17p11.2 Hs.592123 136

transcription factor activity

RNA polymerase II transcription factor activity

protein binding

nucleus

nuclear envelope

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

regulation of transcription from RNA polymerase II promoter

lipid metabolic process

steroid metabolic process

cholesterol metabolic process

cellular response to starvation

membrane

integral to membrane

cytoplasmic vesicle

sterol response element binding

regulation of transcription

Insulin signaling pathway

201397_at PHGDH phosphoglycerate dehydrogenase 1 120055941 NM_006623 1p12 Hs.487296 18

phosphoglycerate dehydrogenase activity

L-serine biosynthetic process

brain development

cellular amino acid biosynthetic process

electron carrier activity

oxidoreductase activity

cofactor binding

NAD or NADH binding

oxidation reduction

Glycine, serine and threonine metabolism

Metabolic pathways

206348_s_at 0.256 3.208 2.679 1.702e-02 0.469 -3.006 PDK3 pyruvate dehydrogenase kinase, isozyme 3 X 24393264, 24393264 NM_005391 Xp22.11 Hs.658190 17

two-component sensor activity

nucleotide binding

pyruvate dehydrogenase (acetyl-transferring) kinase activity

ATP binding

mitochondrion

mitochondrial matrix

carbohydrate metabolic process

glucose metabolic process

signal transduction

transferase activity

peptidyl-histidine phosphorylation

 
209676_at 0.479 3.430 3.119 6.944e-03 0.370 -2.246 TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2 -188051550, -188037202 J03225 2q32 Hs.516578 118

serine-type endopeptidase inhibitor activity

extracellular region

extracellular region

extracellular space

plasma membrane

blood coagulation, extrinsic pathway

Complement and coagulation cascades

221471_at SERINC3 serine incorporator 3 20 -42561314, -42558277 AW173623 20q13.1-q13.3 Hs.272168 Hs.696043 10

protein binding

Golgi apparatus

plasma membrane

induction of apoptosis

integral to membrane

 
209556_at NCDN neurochondrin 1 35795979 AB011179 1p34.3 Hs.121870 8

cytoplasm

dendrite

cell projection

bone resorption

regulation of neuronal synaptic plasticity

 
231801_at NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 20 -49441172, -49441171 AL035682 20q13.2-q13.3 Hs.713650 93

cytokine production

transcription factor activity

protein binding

nucleus

cytoplasm

cytosol

regulation of transcription, DNA-dependent

transcription activator activity

sequence-specific DNA binding

positive regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

MAPK signaling pathway

Wnt signaling pathway

Axon guidance

VEGF signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

221580_s_at TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 11 -93108745 BC001972 11q21 Hs.355750 6

DNA binding

protein binding

nucleus

regulation of transcription

 
229971_at GPR114 G protein-coupled receptor 114 16 56134101 BF057784 16q21 Hs.187884 7

G-protein coupled receptor activity

G-protein coupled receptor activity

plasma membrane

neuropeptide signaling pathway

integral to membrane

integral to membrane

 
211992_at WNK1 WNK lysine deficient protein kinase 1 12 732485 AI445745 12p13.3 Hs.709894 51

nucleotide binding

molecular_function

protein serine/threonine kinase activity

protein kinase inhibitor activity

protein binding

ATP binding

cytoplasm

cytoplasm

protein amino acid phosphorylation

ion transport

protein kinase cascade

biological_process

transferase activity

regulation of cellular process

 
1552258_at NCRNA00152 non-protein coding RNA 152 2 87536088 NM_052871 2p11.2 Hs.652166 2    
1557063_at FLJ45244 hypothetical locus FLJ45244 14 94693777 BC040596 14q32.13 Hs.497573 Hs.712518 1    
217982_s_at MORF4L1 mortality factor 4 like 1 15 76952226 NM_006791 15q24 Hs.374503 25

protein binding

nucleus

DNA repair

response to DNA damage stimulus

chromatin modification

histone deacetylation

Sin3 complex

NuA4 histone acetyltransferase complex

regulation of growth

histone H4 acetylation

histone H2A acetylation

regulation of transcription

 
225729_at C6orf89 chromosome 6 open reading frame 89 6 36961617 AI870857 6p21.2 Hs.433381 10

membrane

integral to membrane

 
214543_x_at QKI quaking homolog, KH domain RNA binding (mouse) 6 163755664, 163755664 AF142421 6q26 6q26-q27 Hs.510324 Hs.593520 23

RNA binding

protein binding

nucleus

nucleolus

cytoplasm

plasma membrane

mRNA processing

regulation of translation

transport

multicellular organismal development

RNA splicing

SH3 domain binding

cell differentiation

mRNA transport

 
201388_at PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 17 35390585 NM_002809 17q21.1 Hs.12970 34

proteasome complex

protein binding

cytosol

enzyme regulator activity

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

214690_at TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 2 9901021 AA004579 2p25 Hs.584833 15

transcription factor activity

nucleus

nucleoplasm

transcription, DNA-dependent

regulation of transcription

 
214108_at MAX MYC associated factor X 14 -64620214, -64614273, -64611597, -64542644 AI346181 14q23 Hs.285354 Hs.712926 56

transcription factor activity

transcription coactivator activity

protein binding

nucleus

cytoplasm

transcription from RNA polymerase II promoter

regulation of transcription

MAPK signaling pathway

Pathways in cancer

Small cell lung cancer

219381_at C5orf42 chromosome 5 open reading frame 42 5 -37142086 NM_023073 5p13.2 Hs.170993 Hs.586199 Hs.643420 Hs.649870 Hs.649889 Hs.705282 4

membrane

integral to membrane

 
1563053_at 0.293 2.099 2.453 2.671e-02 0.523 -3.385 LOC729083 hypothetical protein LOC729083 3   BC038366 3p22.1 Hs.713395      
229272_at FNBP4 formin binding protein 4 11 -47694644 AI083506 11p11.2 Hs.6834 11

protein binding

 
241725_at E2F7 E2F transcription factor 7 12 -75939156 AW511293 12q21.2 Hs.416375 12

transcription factor activity

nucleus

transcription factor complex

regulation of transcription, DNA-dependent

cell cycle

negative regulation of cell proliferation

transcription repressor activity

identical protein binding

 
220626_at SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 14 -93819402, -93819402 NM_016186 14q32.13 Hs.118620 15

serine-type endopeptidase inhibitor activity

extracellular region

peptidase inhibitor activity

 
1552436_a_at CDH23 cadherin-like 23 10 72826709, 72826709 NM_052836 10q21-q22 Hs.656032 37

calcium ion binding

protein binding

plasma membrane

cell adhesion

homophilic cell adhesion

sensory perception of sound

integral to membrane

calcium-dependent cell-cell adhesion

stereocilium

photoreceptor cell maintenance

response to stimulus

equilibrioception

 
212488_at 0.646 5.847 3.157 6.416e-03 0.364 -2.179 COL5A1 collagen, type V, alpha 1 9 136673472 N30339 9q34.2-q34.3 Hs.210283 49

integrin binding

extracellular matrix structural constituent

extracellular region

collagen

collagen type V

cell adhesion

heparin binding

collagen fibril organization

collagen fibril organization

collagen biosynthetic process

wound healing, spreading of epidermal cells

fibril organization

proteoglycan binding

skin development

integrin biosynthetic process

eye morphogenesis

Focal adhesion

ECM-receptor interaction

209533_s_at PLAA phospholipase A2-activating protein 9 -26893368 AF145020 9p21 Hs.27182 15

protein binding

phospholipid metabolic process

inflammatory response

signal transduction

phospholipase A2 activator activity

 
227481_at 0.643 4.602 3.186 6.052e-03 0.360 -2.129 CNKSR3 CNKSR family member 3 6 -154768124 BG165333 6q25.2 Hs.16064 2

protein binding

cytoplasm

regulation of signal transduction

membrane

 
1559645_at NCRNA00184 non-protein coding RNA 184 1   AJ421679 1q42.3 Hs.209162      
235371_at 0.738 4.976 2.818 1.284e-02 0.431 -2.768 GLT8D4 glycosyltransferase 8 domain containing 4 3 73020074 AI452595 3p13 Hs.710275 1

membrane

integral to membrane

transferase activity, transferring glycosyl groups

 
204303_s_at KIAA0427 KIAA0427 18 44319424 NM_014772 18q21.1 Hs.145230 5

protein binding

RNA metabolic process

 
219081_at ANKHD1 ankyrin repeat and KH domain containing 1 5 139761612, 139761612 NM_024668 5q31.3 Hs.594084 12

RNA binding

protein binding

cytoplasm

 
1559920_a_at CECR4 cat eye syndrome chromosome region, candidate 4 (non-protein coding) 22 16020278 AF307448 22q11.1 Hs.660066 1    
223465_at COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 5 -74702683, -74702683 BE967275 5q13.3 Hs.270437 26

protein kinase activity

protein binding

cellular_component

cytoplasm

endoplasmic reticulum

Golgi apparatus

protein amino acid phosphorylation

lipid transport

immune response

 
202130_at RIOK3 RIO kinase 3 (yeast) 18 19286784 AA725102 18q11.2 Hs.445511 Hs.719109 9

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

protein amino acid phosphorylation

chromosome segregation

kinase activity

transferase activity

 
244565_at HMX2 H6 family homeobox 2 10 124897627 AI685824 10q25.2-q26.3 Hs.444756 3

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

nervous system development

brain development

positive regulation of cell proliferation

cell differentiation

inner ear morphogenesis

sequence-specific DNA binding

 
224846_at SHKBP1 SH3KBP1 binding protein 1 19 45774596 AI348000 19q13.2 Hs.26506 7

voltage-gated potassium channel activity

protein binding

potassium ion transport

voltage-gated potassium channel complex

membrane

 
202585_s_at NFX1 nuclear transcription factor, X-box binding 1 9 33280509, 33280509, 33280509 NM_002504 9p13.3 Hs.413074 15

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

inflammatory response

zinc ion binding

ligase activity

modification-dependent protein catabolic process

interspecies interaction between organisms

negative regulation of MHC class II biosynthetic process

metal ion binding

 
209863_s_at TP63 tumor protein p63 3 190831909, 190831909, 190990142, 190990142 AF091627 3q28 Hs.137569 238

response to tumor cell

transcription factor activity

nucleus

nucleus

cytoplasm

apoptosis

induction of apoptosis

multicellular organismal development

zinc ion binding

transcription activator activity

transcription activator activity

transcription repressor activity

negative regulation of cell growth

identical protein binding

positive regulation of Notch signaling pathway

negative regulation of transcription, DNA-dependent

positive regulation of transcription, DNA-dependent

metal ion binding

protein homotetramerization

 
201088_at KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 17 63462309, -1713110 NM_002266 17q24.2 Hs.594238 125

regulation of DNA recombination

M phase specific microtubule process

G2 phase of mitotic cell cycle

protein binding

nucleus

nuclear pore

nucleoplasm

cytoplasm

DNA metabolic process

NLS-bearing substrate import into nucleus

intracellular protein transport

nuclear localization sequence binding

protein transporter activity

interspecies interaction between organisms

 
216082_at NEU3 sialidase 3 (membrane sialidase) 11 74377597 AK022450 11q13.5 Hs.191074 25

exo-alpha-sialidase activity

plasma membrane

integral to plasma membrane

carbohydrate metabolic process

ganglioside catabolic process

metabolic process

hydrolase activity, acting on glycosyl bonds

Other glycan degradation

Sphingolipid metabolism

1562537_at -0.305 3.999 -2.229 4.129e-02 0.571 -3.746 FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 1 157526127 BC015185 1q23 Hs.897 74

positive regulation of type I hypersensitivity

serotonin secretion

receptor activity

plasma membrane

integral to plasma membrane

cell surface receptor linked signal transduction

activation of JUN kinase activity

external side of plasma membrane

leukotriene biosynthetic process

IgE receptor activity

positive regulation of mast cell degranulation

positive regulation of interleukin-3 biosynthetic process

positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of calcium-mediated signaling

Fc epsilon RI signaling pathway

Asthma

51176_at MED27 mediator complex subunit 27 9 -133725319 AA131335 9q34.1-q34.3 Hs.374262 13

transcription coactivator activity

protein binding

nucleus

cytoplasm

regulation of transcription from RNA polymerase II promoter

transcription initiation from RNA polymerase II promoter

regulation of transcription

 
220601_at C16orf70 chromosome 16 open reading frame 70 16 65701415 NM_025187 16q22.1 Hs.513666 7

protein binding

 
202832_at GCC2 GRIP and coiled-coil domain containing 2 2 108432008, 108432067 NM_014635 2q12.3 Hs.436505 Hs.469630 19

cytoplasm

Golgi apparatus

membrane

identical protein binding

 
225424_at GPAM glycerol-3-phosphate acyltransferase, mitochondrial 10 -113899611 AB046780 10q25.2 Hs.42586 16

glycerol-3-phosphate O-acyltransferase activity

glycerol-3-phosphate O-acyltransferase activity

mitochondrion

mitochondrial outer membrane

cytosol

metabolic process

acyltransferase activity

phospholipid biosynthetic process

membrane

integral to membrane

transferase activity

triglyceride biosynthetic process

Glycerolipid metabolism

Glycerophospholipid metabolism

Metabolic pathways

220252_x_at CXorf21 chromosome X open reading frame 21 X -30486861 NM_025159 Xp21.2 Hs.665009 4    
221185_s_at IQCG IQ motif containing G 3 -199100344, -199100343 NM_025111 3q29 Hs.591675 6    
225179_at UBE2K ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) 4 39376058 AA161140 4p14 Hs.50308 Hs.714332 20

nucleotide binding

ubiquitin-protein ligase activity

protein binding

ATP binding

cytoplasm

ubiquitin-dependent protein catabolic process

ligase activity

ubiquitin protein ligase binding

post-translational protein modification

regulation of protein metabolic process

Ubiquitin mediated proteolysis

205240_at 0.415 5.059 2.551 2.199e-02 0.499 -3.222 GPSM2 G-protein signaling modulator 2 (AGS3-like, C. elegans) 1 109221125 NM_013296 1p13.3 Hs.584901 11

GTPase activator activity

nucleus

nucleolus

cytoplasm

Golgi apparatus

cell cortex

signal transduction

G-protein coupled receptor protein signaling pathway

identical protein binding

 
230258_at 0.522 3.944 2.788 1.365e-02 0.440 -2.820 GLIS3 GLIS family zinc finger 3 9 -3814127, -3814127 AI277316 9p24.2 Hs.162125 Hs.644570 8

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

specific RNA polymerase II transcription factor activity

intracellular

zinc ion binding

nuclear part

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

metal ion binding

 
1554556_a_at -0.281 5.296 -2.820 1.280e-02 0.431 -2.765 ATP11B ATPase, class VI, type 11B 3 183993984 BC033880 3q27 Hs.478429 8

nucleotide binding

magnesium ion binding

phospholipid-translocating ATPase activity

ATP binding

nuclear inner membrane

ATP biosynthetic process

ion transport

metabolic process

ion transmembrane transporter activity

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

phospholipid transport

aminophospholipid transport

membrane

integral to membrane

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

 
228748_at CD59 CD59 molecule, complement regulatory protein 11 -33681131, -33681131, -33681131 AI653117 11p13 Hs.278573 Hs.709466 Hs.710641 107

protein binding

extracellular region

membrane fraction

plasma membrane

cell surface receptor linked signal transduction

blood coagulation

anchored to membrane

anchored to external side of plasma membrane

Complement and coagulation cascades

Hematopoietic cell lineage

230351_at 0.615 5.499 3.680 2.182e-03 0.276 -1.261 LOC283481 hypothetical protein LOC283481 13   AW070248 13q33.1 Hs.646604 2    
216180_s_at SYNJ2 synaptojanin 2 6 158322906 AK026758 6q25.3 Hs.434494 18

RNA binding

inositol or phosphatidylinositol phosphatase activity

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

protein binding

membrane

dephosphorylation

hydrolase activity

Inositol phosphate metabolism

Metabolic pathways

Phosphatidylinositol signaling system

336_at -0.380 5.580 -3.459 3.447e-03 0.308 -1.650 TBXA2R thromboxane A2 receptor 19 -3545503 D38081 19p13.3 Hs.442530 79

receptor activity

G-protein coupled receptor activity

thromboxane A2 receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

regulation of vasoconstriction

second-messenger-mediated signaling

positive regulation of smooth muscle contraction

Calcium signaling pathway

Neuroactive ligand-receptor interaction

207993_s_at 0.592 4.787 4.163 8.097e-04 0.214 -0.422 CHP calcium binding protein P22 15 39310728 NM_007236 15q13.3 Hs.406234 Hs.706184 21

calcium ion binding

cytoplasm

potassium ion transport

small GTPase mediated signal transduction

potassium channel regulator activity

MAPK signaling pathway

Calcium signaling pathway

Apoptosis

Wnt signaling pathway

Axon guidance

VEGF signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Long-term potentiation

Alzheimer's disease

Amyotrophic lateral sclerosis (ALS)

218421_at CERK ceramide kinase 22 -45458970 NM_022766 22q13.31 Hs.200668 21

nucleotide binding

magnesium ion binding

integral to membrane of membrane fraction

ceramide kinase activity

diacylglycerol kinase activity

calcium ion binding

ATP binding

nucleus

cytoplasm

ceramide metabolic process

activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway

membrane

transferase activity

Sphingolipid metabolism

243116_at PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1 9 -129723630, -129723628 AI923090 9q34.11 Hs.445486 2

nucleotide binding

protein binding

ATP binding

cytoplasm

membrane

kinase activity

1-phosphatidylinositol-4-phosphate 5-kinase activity

transferase activity

cell projection

phosphatidylinositol metabolic process

 
1556411_s_at KY kyphoscoliosis peptidase 3 -135801454 AF086360 3q22.2 Hs.146730 4

cytoplasm

cytoskeleton

peptidase activity

 
212187_x_at PTGDS prostaglandin D2 synthase 21kDa (brain) 9 138991776 NM_000954 9q34.2-q34.3 Hs.446429 63

prostaglandin biosynthetic process

prostaglandin-D synthase activity

transporter activity

binding

retinoid binding

extracellular region

nucleus

cytoplasm

rough endoplasmic reticulum

Golgi apparatus

fatty acid biosynthetic process

transport

membrane

isomerase activity

nuclear membrane

regulation of circadian sleep/wake cycle, sleep

perinuclear region of cytoplasm

Arachidonic acid metabolism

Metabolic pathways

210830_s_at 0.516 6.702 2.715 1.583e-02 0.459 -2.945 PON2 paraoxonase 2 7 -94872109 AF001602 7q21.3 Hs.719159 112

aryldialkylphosphatase activity

arylesterase activity

extracellular region

plasma membrane

hydrolase activity

aromatic compound catabolic process

identical protein binding

gamma-Hexachlorocyclohexane degradation

Bisphenol A degradation

Metabolic pathways

220484_at MCOLN3 mucolipin 3 1 -85256352 NM_018298 1p22.3 Hs.535239 11

ion channel activity

ion transport

membrane

integral to membrane

 
220929_at GALNT8 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8) 12 4700012 NM_017417 12p13.3 Hs.511985 2

polypeptide N-acetylgalactosaminyltransferase activity

calcium ion binding

sugar binding

Golgi apparatus

membrane

integral to membrane

transferase activity, transferring glycosyl groups

manganese ion binding

O-Glycan biosynthesis

Metabolic pathways

216484_x_at HDGF hepatoma-derived growth factor (high-mobility group protein 1-like) 1 -154978522, -154978522, -154978522 L24521 1q21-q23 Hs.506748 22

nucleotide binding

DNA binding

extracellular space

nucleus

cytoplasm

signal transduction

growth factor activity

heparin binding

cell proliferation

regulation of transcription

 
214434_at HSPA12A heat shock 70kDa protein 12A 10 -118420692 AB007877 10q26.12 Hs.654682 8

nucleotide binding

ATP binding

 
205685_at CD86 CD86 molecule 3 123256910, 123279439 BG236280 3q21 Hs.171182 97

protein binding

plasma membrane

immune response

cell-cell signaling

positive regulation of cell proliferation

coreceptor activity

integral to membrane

transcription activator activity

T cell activation

positive regulation of lymphotoxin A biosynthetic process

interspecies interaction between organisms

positive regulation of interleukin-2 biosynthetic process

positive regulation of interleukin-4 biosynthetic process

positive regulation of T-helper 2 cell differentiation

positive regulation of transcription

Cell adhesion molecules (CAMs)

Toll-like receptor signaling pathway

Type I diabetes mellitus

Autoimmune thyroid disease

Systemic lupus erythematosus

Allograft rejection

Graft-versus-host disease

36545_s_at SFI1 Sfi1 homolog, spindle assembly associated (yeast) 22 30222260 AB011114 22q12.2 Hs.62209 7

centrosome

 
208447_s_at PRPS1 phosphoribosyl pyrophosphate synthetase 1 X 106758309 NM_002764 Xq21.32-q24 Hs.56 26

nucleotide binding

magnesium ion binding

ribose phosphate diphosphokinase activity

ribose phosphate diphosphokinase activity

ribose phosphate diphosphokinase activity

ATP binding

cytosol

purine base metabolic process

purine nucleotide biosynthetic process

pyrimidine nucleotide biosynthetic process

nervous system development

nucleoside metabolic process

ribonucleoside monophosphate biosynthetic process

kinase activity

transferase activity

urate biosynthetic process

protein homodimerization activity

hypoxanthine biosynthetic process

Pentose phosphate pathway

Purine metabolism

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of plant hormones

Metabolic pathways

207137_at NFKBIL2 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 8 -145624970 NM_013432 8q24.3 Hs.675285 6

transcription corepressor activity

protein binding

cytoplasm

cytoplasmic sequestering of transcription factor

 
205320_at APC2 adenomatosis polyposis coli 2 19 1401147 NM_005883 19p13.3 Hs.446376 9

cytoplasm

Golgi apparatus

cytoskeleton

microtubule

plasma membrane

protein complex assembly

signal transduction

beta-catenin binding

microtubule binding

Wnt receptor signaling pathway

catenin complex

Wnt signaling pathway

Regulation of actin cytoskeleton

Pathways in cancer

Colorectal cancer

Endometrial cancer

Basal cell carcinoma

209393_s_at EIF4E2 eukaryotic translation initiation factor 4E family member 2 2 233123600 AF047695 2q37.1 Hs.292026 Hs.700929 15

RNA cap binding

translation initiation factor activity

protein binding

cytoplasm

translational initiation

regulation of translation

mTOR signaling pathway

Insulin signaling pathway

202235_at -0.592 7.042 -3.183 6.092e-03 0.360 -2.135 SLC16A1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1) 1 -113255992 BF511091 1p12 Hs.75231 43

protein binding

membrane fraction

plasma membrane

transport

mevalonate transmembrane transporter activity

symporter activity

secondary active monocarboxylate transmembrane transporter activity

organic anion transport

mevalonate transport

integral to membrane

 
221522_at ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 19 -37779746 AL136784 19q13.11 Hs.59236 12

guanyl-nucleotide exchange factor activity

GTPase activator activity

protein binding

cytoplasm

lysosome

early endosome

early endosome to late endosome transport

 
1553678_a_at 0.513 8.235 2.886 1.119e-02 0.426 -2.652 ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 10 -33236244, -33229251, -33229251, -33229251 NM_133376 10p11.2 Hs.643813 512

G1/S transition of mitotic cell cycle

in utero embryonic development

cell fate specification

receptor activity

integrin binding

focal adhesion

cellular defense response

cell adhesion

homophilic cell adhesion

leukocyte adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

positive regulation of cell proliferation

integrin complex

germ cell migration

cell surface

integral to membrane

synaptosome

B cell differentiation

neuromuscular junction

ruffle membrane

cell-cell adhesion mediated by integrin

sarcolemma

melanosome

identical protein binding

interspecies interaction between organisms

sarcomere organization

negative regulation of cell differentiation

protein heterodimerization activity

regulation of cell cycle

cardiac muscle cell differentiation

Axon guidance

Focal adhesion

ECM-receptor interaction

Cell adhesion molecules (CAMs)

Leukocyte transendothelial migration

Regulation of actin cytoskeleton

Pathogenic Escherichia coli infection - EHEC

Pathways in cancer

Small cell lung cancer

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

223605_at SLC25A18 solute carrier family 25 (mitochondrial carrier), member 18 22 16423182 AY008285 22q11.2 Hs.282982 Hs.629929 7

binding

mitochondrion

mitochondrial inner membrane

transport

symporter activity

membrane

integral to membrane

 
1558028_x_at LOC647979 hypothetical LOC647979 20 -34096955 BI857154 20q11.23 Hs.649310 Hs.718413 2    
230151_at C13orf1 chromosome 13 open reading frame 1 13 -49384842 AW009330 13q14 Hs.44235 11    
225055_at LOC651250 hypothetical LOC651250 17 63609332 AV735241 17q24.2 Hs.293560 Hs.591212 Hs.647405 Hs.655146 Hs.663262 3    
225019_at CAMK2D calcium/calmodulin-dependent protein kinase II delta 4 -114597792, -114591638 BF797381 4q26 Hs.144114 29

G1/S transition of mitotic cell cycle

nucleotide binding

regulation of cell growth

calmodulin-dependent protein kinase activity

calmodulin binding

ATP binding

nucleus

cytoplasm

calcium- and calmodulin-dependent protein kinase complex

calcium ion transport

transferase activity

T-tubule

protein amino acid autophosphorylation

cardiac muscle contraction

ErbB signaling pathway

Calcium signaling pathway

Wnt signaling pathway

Long-term potentiation

Neurotrophin signaling pathway

Olfactory transduction

GnRH signaling pathway

Melanogenesis

Glioma

209440_at PRPS1 phosphoribosyl pyrophosphate synthetase 1 X 106758309 BC001605 Xq21.32-q24 Hs.56 26

nucleotide binding

magnesium ion binding

ribose phosphate diphosphokinase activity

ribose phosphate diphosphokinase activity

ribose phosphate diphosphokinase activity

ATP binding

cytosol

purine base metabolic process

purine nucleotide biosynthetic process

pyrimidine nucleotide biosynthetic process

nervous system development

nucleoside metabolic process

ribonucleoside monophosphate biosynthetic process

kinase activity

transferase activity

urate biosynthetic process

protein homodimerization activity

hypoxanthine biosynthetic process

Pentose phosphate pathway

Purine metabolism

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of plant hormones

Metabolic pathways

224436_s_at 0.616 7.121 2.291 3.661e-02 0.560 -3.647 NIPSNAP3A nipsnap homolog 3A (C. elegans) 9 106549789 BC005935 9q31.1 Hs.530275 6

cytoplasm

cytosol

 
212698_s_at SEPT10 septin 10 2 -109657664 BF966021 2q13 Hs.469615 6

nucleotide binding

protein binding

GTP binding

nucleus

cytoplasm

cell cycle

septin complex

cell division

 
1570279_at ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 9 -106583104 BC034824 9q31.1 Hs.719214 321

nucleotide binding

ATP binding

phospholipid binding

phospholipid transporter activity

membrane fraction

integral to plasma membrane

lipid metabolic process

transport

lysosome organization

G-protein coupled receptor protein signaling pathway

steroid metabolic process

cholesterol metabolic process

anion transmembrane transporter activity

negative regulation of foam cell differentiation

negative regulation of cholesterol storage

cholesterol binding

membrane

endosome transport

ATPase activity

cholesterol transporter activity

syntaxin-13 binding

positive regulation of cAMP biosynthetic process

small GTPase binding

intracellular cholesterol transport

Cdc42 protein signal transduction

cholesterol efflux

cholesterol efflux

phospholipid efflux

phospholipid efflux

apolipoprotein A-I receptor activity

high-density lipoprotein particle assembly

cholesterol homeostasis

reverse cholesterol transport

membrane raft

phagocytic vesicle

interleukin-1 beta secretion

phospholipid homeostasis

platelet dense granule organization

ABC transporters

205356_at USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 3 180853626 NM_003940 3q26.2-q26.3 Hs.175322 11

cysteine-type endopeptidase activity

ubiquitin thiolesterase activity

ubiquitin-specific protease activity

ubiquitin-dependent protein catabolic process

peptidase activity

zinc ion binding

metal ion binding

 
209220_at GPC3 glypican 3 X -132497441 L47125 Xq26.1 Hs.644108 53

extracellular region

proteinaceous extracellular matrix

extracellular space

plasma membrane

integral to plasma membrane

anatomical structure morphogenesis

anchored to membrane

heparan sulfate proteoglycan binding

 
1564783_x_at -0.237 4.534 -2.181 4.530e-02 0.581 -3.823 OFCC1 orofacial cleft 1 candidate 1 6   AF520806 6p24.3 Hs.532138 2    
224559_at 0.607 7.327 2.868 1.161e-02 0.426 -2.682 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 11 65021808 AF001540 11q13.1 Hs.642877 Hs.714394 8    
212898_at KIAA0406 KIAA0406 20 -36044836 AB007866 20q11.23 Hs.655481 5

binding

 
1559489_a_at -0.215 4.708 -2.279 3.749e-02 0.563 -3.667 LOC257358 hypothetical LOC257358 5 169691012 AK093725 5q35.1 Hs.249689 3    
219970_at GIPC2 GIPC PDZ domain containing family, member 2 1 78284176 NM_017655 1p31.1 Hs.659356 9

protein binding

cytoplasm

 
203589_s_at 0.458 5.744 2.375 3.112e-02 0.543 -3.512 TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 3 -143154017 NM_006286 3q23 Hs.379018 14

transcription factor activity

transcription cofactor activity

nucleus

transcription factor complex

regulation of transcription, DNA-dependent

cell cycle

protein domain specific binding

Cell cycle

211994_at WNK1 WNK lysine deficient protein kinase 1 12 732485 AI742553 12p13.3 Hs.709894 51

nucleotide binding

molecular_function

protein serine/threonine kinase activity

protein kinase inhibitor activity

protein binding

ATP binding

cytoplasm

cytoplasm

protein amino acid phosphorylation

ion transport

protein kinase cascade

biological_process

transferase activity

regulation of cellular process

 
204411_at KIF21B kinesin family member 21B 1 -199205142 NM_017596 1pter-q31.3 Hs.169182 3

nucleotide binding

microtubule motor activity

ATP binding

cytoplasm

microtubule

microtubule-based movement

 
220495_s_at TXNDC15 thioredoxin domain containing 15 5 134237358 NM_024715 5q31.1 Hs.696335 7

membrane

integral to membrane

cell redox homeostasis

 
202416_at DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 17 -37381982, -37381982 NM_003315 17q11.2 Hs.500156 13

protein folding

heat shock protein binding

 
207320_x_at STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) 20 -47163282 NM_004602 20q13.1 Hs.596704 26

double-stranded RNA binding

protein binding

intracellular

rough endoplasmic reticulum

microtubule associated complex

intracellular mRNA localization

ribonucleoprotein complex

 
211851_x_at -0.324 5.731 -3.235 5.469e-03 0.352 -2.043 BRCA1 breast cancer 1, early onset 17 -38449838, -38449838, -38449838, -38449838 AF005068 17q21 Hs.194143 1201

ubiquitin ligase complex

double-strand break repair via homologous recombination

condensed chromosome

damaged DNA binding

transcription coactivator activity

ubiquitin-protein ligase activity

intracellular

nucleus

nucleoplasm

cytoplasm

DNA replication

postreplication repair

regulation of transcription from RNA polymerase II promoter

regulation of transcription from RNA polymerase III promoter

response to DNA damage stimulus

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

cell cycle

chromosome segregation

centrosome cycle

zinc ion binding

gamma-tubulin ring complex

DNA damage response, signal transduction resulting in induction of apoptosis

dosage compensation, by inactivation of X chromosome

response to ionizing radiation

tubulin binding

negative regulation of transcription

ligase activity

enzyme binding

modification-dependent protein catabolic process

androgen receptor signaling pathway

ribonucleoprotein complex

positive regulation of protein ubiquitination

BRCA1-BARD1 complex

G2/M transition DNA damage checkpoint

regulation of cell proliferation

identical protein binding

regulation of apoptosis

chordate embryonic development

response to estrogen stimulus

negative regulation of fatty acid biosynthetic process

positive regulation of DNA repair

positive regulation of transcription, DNA-dependent

negative regulation of centriole replication

metal ion binding

androgen receptor binding

BRCA1-A complex

Ubiquitin mediated proteolysis

202093_s_at PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 19 -44568109 NM_019088 19q13.1 Hs.466714 5

nucleus

histone monoubiquitination

Cdc73/Paf1 complex

histone H2B ubiquitination

regulation of transcription

 
203849_s_at -0.330 4.367 -3.244 5.365e-03 0.351 -2.027 KIF1A kinesin family member 1A 2 -241301856 BG473130 2q37.3 Hs.516802 21

nucleotide binding

microtubule motor activity

ATP binding

microtubule

microtubule-based movement

anterograde axon cargo transport

 
211762_s_at KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 17 63462309, -1713110 BC005978 17q24.2 Hs.594238 125

regulation of DNA recombination

M phase specific microtubule process

G2 phase of mitotic cell cycle

protein binding

nucleus

nuclear pore

nucleoplasm

cytoplasm

DNA metabolic process

NLS-bearing substrate import into nucleus

intracellular protein transport

nuclear localization sequence binding

protein transporter activity

interspecies interaction between organisms

 
205290_s_at BMP2 bone morphogenetic protein 2 20 6696744 NM_001200 20p12 Hs.73853 195

branching involved in ureteric bud morphogenesis

cytokine activity

extracellular region

extracellular region

extracellular space

inflammatory response

cell-cell signaling

growth factor activity

negative regulation of cell proliferation

embryonic development

organ morphogenesis

positive regulation of pathway-restricted SMAD protein phosphorylation

specific transcriptional repressor activity

positive regulation of bone mineralization

BMP signaling pathway

BMP signaling pathway

negative regulation of gene-specific transcription

cardiac cell differentiation

growth

odontogenesis of dentine-containing tooth

cell fate commitment

positive regulation of osteoblast differentiation

negative regulation of cell cycle

positive regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

SMAD binding

positive regulation of astrocyte differentiation

cartilage development

cardiac epithelial to mesenchymal transition

Cytokine-cytokine receptor interaction

Hedgehog signaling pathway

TGF-beta signaling pathway

Pathways in cancer

Basal cell carcinoma

214670_at 0.445 5.726 2.403 2.942e-02 0.536 -3.465 ZKSCAN1 zinc finger with KRAB and SCAN domains 1 7 99451154 AA653300 7q21.3-q22.1 Hs.615360 11

transcription factor activity

intracellular

nucleus

cytoplasm

mitochondrion

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
213036_x_at -0.260 6.100 -2.614 1.937e-02 0.489 -3.115 ATP2A3 ATPase, Ca++ transporting, ubiquitous 17 -3773917 Y15724 17p13.3 Hs.513870 27

nucleotide binding

magnesium ion binding

calcium-transporting ATPase activity

calcium ion binding

protein binding

ATP binding

nucleus

ATP biosynthetic process

cation transport

calcium ion transport

metabolic process

membrane

integral to membrane

sarcoplasmic reticulum

hydrolase activity

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Calcium signaling pathway

Alzheimer's disease

229018_at C12orf26 chromosome 12 open reading frame 26 12 81276454 AI310001 12q21.31 Hs.506222 3    
210940_s_at GRM1 glutamate receptor, metabotropic 1 6 146390474 U31216 6q24 Hs.32945 51

receptor activity

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

synaptic transmission

glutamate receptor activity

Calcium signaling pathway

Neuroactive ligand-receptor interaction

Gap junction

Long-term potentiation

Long-term depression

216525_x_at PMS2L3 postmeiotic segregation increased 2-like 3 7 -74975005, -74975004 D38437 7q11.23 Hs.406395 Hs.659871 Hs.661055 4

molecular_function

nucleic acid binding

ATP binding

cellular_component

intracellular

regulation of transcription, DNA-dependent

biological_process

 
229849_at WIPF3 WAS/WASL interacting protein family, member 3 7 29840865 AI807950 7p14.3 Hs.709280 5

actin binding

cytoplasm

multicellular organismal development

spermatogenesis

cell differentiation

 
231930_at ELMOD1 ELMO/CED-12 domain containing 1 11 106967026 AL359601 11q22.3 Hs.495779 5

cytoskeleton

phagocytosis

 
201750_s_at ECE1 endothelin converting enzyme 1 1 -21416326, -21416326, -21416326, -21416326 NM_001397 1p36.1 Hs.195080 63

response to hypoxia

positive regulation of receptor recycling

regulation of systemic arterial blood pressure by endothelin

metalloendopeptidase activity

membrane fraction

endosome

Golgi apparatus

plasma membrane

proteolysis

apoptosis

heart development

peptidase activity

zinc ion binding

external side of plasma membrane

substance P catabolic process

bradykinin catabolic process

calcitonin catabolic process

integral to membrane

peptide hormone binding

regulation of vasoconstriction

intrinsic to endosome membrane

vesicle

Weibel-Palade body

endothelin maturation

embryonic digit morphogenesis

protein homodimerization activity

ear development

positive regulation of G-protein coupled receptor protein signaling pathway

metal ion binding

perinuclear region of cytoplasm

 
204573_at CROT carnitine O-octanoyltransferase 7 86812886, 86812886 NM_021151 7q21.1 Hs.125039 11

peroxisome

generation of precursor metabolites and energy

lipid metabolic process

fatty acid metabolic process

transport

acyltransferase activity

carnitine O-octanoyltransferase activity

fatty acid transport

transferase activity

 
210395_x_at MYL4 myosin, light chain 4, alkali; atrial, embryonic 17 42641426, 42641712 AF116676 17q21-qter Hs.463300 21

regulation of the force of heart contraction

motor activity

actin monomer binding

calcium ion binding

muscle myosin complex

muscle organ development

structural constituent of muscle

myosin complex

A band

myosin II heavy chain binding

positive regulation of ATPase activity

actin filament binding

cardiac muscle contraction

Cardiac muscle contraction

1569895_at -0.282 6.971 -2.635 1.858e-02 0.486 -3.080 LOC100133612 similar to hCG1815312 1 3806827 BC016994 1p36.32 Hs.307652 1    
238925_at SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 16 67778550 AW958415 16q22-q23 Hs.461117 22

actin binding

calcium ion binding

calmodulin binding

membrane fraction

cytoplasm

cytoskeleton

microtubule

dystrophin-associated glycoprotein complex

membrane

cell junction

cytoplasmic vesicle

synapse

 
241496_at BTNL9 butyrophilin-like 9 5 180399830 BE551319 5q35.3 Hs.546502 4

membrane

integral to membrane

 
212885_at 0.440 7.356 2.510 2.382e-02 0.509 -3.289 MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 2 71210951 AL545921 2p13.3 Hs.656208 10

protein binding

nucleus

nucleolus

small nucleolar ribonucleoprotein complex

rRNA processing

RNA splicing

RNA splicing factor activity, transesterification mechanism

 
224501_at C1orf170 chromosome 1 open reading frame 170 1 -900441 BC006300 1p36.33 Hs.271462 2    
229801_at C10orf47 chromosome 10 open reading frame 47 10 11905402 AI640157 10p14 Hs.435775 4    
230704_s_at ITGB4 integrin, beta 4 17 71229110, 71232370 AI418058 17q25 Hs.632226 120

receptor activity

protein binding

cell communication

cell adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

integrin complex

membrane

integral to membrane

Focal adhesion

ECM-receptor interaction

Regulation of actin cytoskeleton

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

218330_s_at NAV2 neuron navigator 2 11 19328846, 19691456, 20001211 NM_018162 11p15.1 Hs.502116 Hs.551898 Hs.639427 Hs.639428 18

nucleotide binding

helicase activity

ATP binding

nucleus

nucleolus

cytoplasm

hydrolase activity

 
232938_at -0.216 4.389 -2.410 2.905e-02 0.534 -3.455 SFMBT2 Scm-like with four mbt domains 2 10 -7244254 AL118884 10p14 Hs.407983 3

nucleus

regulation of transcription

 
211575_s_at UBE3A ubiquitin protein ligase E3A 15 -23133488, -23133488, -23133488 AF116702 15q11-q13 Hs.598862 76

ubiquitin-protein ligase activity

protein binding

intracellular

nucleus

cytosol

protein modification process

proteolysis

ubiquitin-dependent protein catabolic process

brain development

protein ubiquitination

ligase activity

acid-amino acid ligase activity

protein complex

interspecies interaction between organisms

Ubiquitin mediated proteolysis

244250_at ANXA6 annexin A6 5 -150460460 AI917653 5q32-q34 Hs.412117 40

calcium ion binding

protein binding

calcium-dependent phospholipid binding

cytoplasm

melanosome

 
221749_at YTHDF3 YTH domain family, member 3 8 64243674 AU157915 8q12.3 Hs.491861 9

cytoplasm

 
218983_at 0.801 4.906 3.591 2.620e-03 0.287 -1.417 C1RL complement component 1, r subcomponent-like 12 -7138290 NM_016546 12p13.31 Hs.631730 8

serine-type endopeptidase activity

extracellular region

extracellular space

proteolysis

complement activation, classical pathway

peptidase activity

innate immune response

 
220185_at SPTBN4 spectrin, beta, non-erythrocytic 4 19 45664965, 45728234 NM_025213 19q13.13 Hs.32706 11

actin binding

structural constituent of cytoskeleton

protein binding

cytoplasm

cytoskeleton

cell cortex

cytoskeletal anchoring at plasma membrane

axonogenesis

sensory perception of sound

adult walking behavior

spectrin

fertilization

vesicle-mediated transport

nuclear matrix

PML body

transmission of nerve impulse

axon

ankyrin binding

adult behavior

positive regulation of multicellular organism growth

axon hillock

actin filament capping

 
228437_at CNIH4 cornichon homolog 4 (Drosophila) 1 222611217 AA834560 1q42.11 Hs.195403 Hs.445890 11

protein binding

endoplasmic reticulum

intracellular signaling cascade

membrane

integral to membrane

 
1554385_a_at 0.305 4.861 2.166 4.663e-02 0.582 -3.847 PADI2 peptidyl arginine deiminase, type II 1 -17265842 BC009701 1p36.13 Hs.33455 20

protein-arginine deiminase activity

calcium ion binding

cytoplasm

protein modification process

hydrolase activity

peptidyl-citrulline biosynthetic process from peptidyl-arginine

 
235675_at 0.242 2.553 2.181 4.525e-02 0.581 -3.822 DHFRL1 dihydrofolate reductase-like 1 3 -95259455 AW104373 3q11.1 Hs.718516 4

dihydrofolate reductase activity

glycine biosynthetic process

nucleotide biosynthetic process

NADP or NADPH binding

 
203394_s_at HES1 hairy and enhancer of split 1, (Drosophila) 3 195336627 BE973687 3q28-q29 Hs.250666 44

in utero embryonic development

liver development

DNA binding

nucleus

cytoplasm

regulation of transcription, DNA-dependent

cell adhesion

positive regulation of cell proliferation

positive regulation of specific transcription from RNA polymerase II promoter

negative regulation of specific transcription from RNA polymerase II promoter

transcription repressor activity

midbrain-hindbrain boundary morphogenesis

oculomotor nerve development

trochlear nerve development

hindbrain morphogenesis

neural tube development

pituitary gland development

lung development

midbrain development

auditory receptor cell fate determination

cell fate commitment

negative regulation of auditory receptor cell differentiation

negative regulation of neuron differentiation

cell maturation

cell morphogenesis involved in neuron differentiation

regulation of neurogenesis

regulation of timing of neuron differentiation

Notch signaling pathway

Maturity onset diabetes of the young

241450_at RSPO1 R-spondin homolog (Xenopus laevis) 1 -37849537 AI224952 1p34.3 Hs.135015 13

extracellular region

heparin binding

Wnt receptor signaling pathway

response to stimulus

 
215859_at NCLN nicalin homolog (zebrafish) 19 3136874 AK022309 19p13.3 Hs.657032 11

protein binding

nucleus

nucleolus

endoplasmic reticulum

membrane

integral to membrane

protein processing

 
209800_at KRT16 keratin 16 17 -37019556 AF061812 17q12-q21 Hs.655160 29

structural constituent of cytoskeleton

protein binding

intermediate filament

cell proliferation

epidermis development

intermediate filament cytoskeleton organization

 
235402_at C11orf66 chromosome 11 open reading frame 66 11 61005167 AI866146 11q12.2 Hs.502726 3    
200906_s_at PALLD palladin, cytoskeletal associated protein 4 169654791 AK025843 4q32.3 Hs.151220 40

actin binding

protein binding

nucleus

cytoplasm

cytoskeleton

actin filament

cytoskeleton organization

muscle alpha-actinin binding

 
231397_at PAP2D phosphatidic acid phosphatase type 2 1 -99128388 AF131783 1p21.3 Hs.483948 4

membrane

integral to membrane

hydrolase activity

 
217561_at 0.334 3.046 2.230 4.125e-02 0.571 -3.746 CALCA calcitonin-related polypeptide alpha 11 -14946623, -14944791 BF447272 11p15.2-p15.1 Hs.37058 137

endothelial cell proliferation

vasculature development

neurological system process involved in regulation of systemic arterial blood pressure

vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure

regulation of heart rate

hormone activity

extracellular region

extracellular space

intracellular

nucleus

cytoplasm

leukocyte adhesion

activation of adenylate cyclase activity by G-protein signaling pathway

neuropeptide signaling pathway

cell-cell signaling

embryo implantation

feeding behavior

response to heat

negative regulation of calcium ion transport into cytosol

negative regulation of transcription

negative regulation of ossification

axon

negative regulation of neurological system process

calcitonin receptor binding

calcitonin receptor binding

activation of protein kinase activity

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-8 production

cell soma

terminal button

endothelial cell migration

positive regulation of macrophage differentiation

negative regulation of osteoclast differentiation

positive regulation of adenylate cyclase activity

negative regulation of blood pressure

positive regulation of ossification

negative regulation of bone resorption

positive regulation of cell adhesion

positive regulation of vasodilation

negative regulation of smooth muscle contraction

response to pain

regulation of inflammatory response

detection of temperature stimulus involved in sensory perception of pain

cytosolic calcium ion homeostasis

elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)

 
232249_at FMNL3 formin-like 3 12 -48317990 AL162062 12q13.12 Hs.179838 6

actin binding

protein binding

cellular component organization

Rho GTPase binding

actin cytoskeleton organization

 
212268_at 0.509 6.390 2.715 1.582e-02 0.459 -2.945 SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 6 -2778732 NM_030666 6p25 Hs.381167 18

serine-type endopeptidase inhibitor activity

cytoplasm

peptidase inhibitor activity

 
221730_at 0.884 5.878 3.767 1.824e-03 0.270 -1.109 COL5A2 collagen, type V, alpha 2 2 -189604885 NM_000393 2q14-q32 Hs.445827 29

molecular_function

extracellular matrix structural constituent

extracellular region

collagen

collagen type V

collagen fibril organization

collagen fibril organization

skin development

skin development

eye morphogenesis

Focal adhesion

ECM-receptor interaction

205567_at CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 11 -45627002 NM_003654 11p11.2-p11.1 Hs.104576 18

Golgi membrane

Golgi apparatus

polysaccharide metabolic process

galactose metabolic process

inflammatory response

membrane

integral to membrane

transferase activity

keratan sulfate metabolic process

keratan sulfotransferase activity

Keratan sulfate biosynthesis

Metabolic pathways

227141_at 0.408 6.809 2.913 1.058e-02 0.418 -2.604 TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) 1 74971423, 74971427, 74971449 AW205739 1p31.1 Hs.348411 6

tRNA processing

methyltransferase activity

transferase activity

 
243526_at -0.394 4.336 -3.207 5.798e-03 0.357 -2.093 WDR86 WD repeat domain 86 7 -150709139 AI968904 7q36.1 Hs.647083 2    
234376_at -0.234 4.981 -2.135 4.942e-02 0.590 -3.894 MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 2 15998133 M55330 2p24.1 Hs.25960 115

chromatin

transcription factor activity

protein binding

nucleus

regulation of transcription from RNA polymerase II promoter

 
230637_at -0.424 7.174 -2.874 1.147e-02 0.426 -2.672 SFXN4 sideroflexin 4 10 -120890414 BF109381 10q26.11 Hs.655168 6

iron ion binding

mitochondrion

cation transport

iron ion transport

cation transmembrane transporter activity

membrane

integral to membrane

 
223975_at SPRYD5 SPRY domain containing 5 11 55407348 BC005014 11q11 Hs.326734 2    
223938_at -0.232 5.726 -2.515 2.361e-02 0.508 -3.282 C1orf49 chromosome 1 open reading frame 49 1 176748834 AL136694 1q25.2 Hs.534501 10

microtubule cytoskeleton

 
214198_s_at DGCR2 DiGeorge syndrome critical region gene 2 22 -17403794 AU150824 22q11.21 Hs.517357 14

receptor activity

protein binding

sugar binding

microsome

cell adhesion

organ morphogenesis

membrane

integral to membrane

response to drug

 
208682_s_at MAGED2 melanoma antigen family D, 2 X 54850895, 54851521, 54852217 AF126181 Xp11.2 Hs.522665 13    
224882_at 0.509 6.600 2.900 1.086e-02 0.422 -2.626 ACSS1 acyl-CoA synthetase short-chain family member 1 20 -24934872 AL035661 20p11.23-p11.21 Hs.529353 7

nucleotide binding

acetate-CoA ligase activity

ATP binding

mitochondrion

mitochondrial matrix

metabolic process

AMP binding

ligase activity

Glycolysis / Gluconeogenesis

Pyruvate metabolism

Propanoate metabolism

Reductive carboxylate cycle (CO2 fixation)

Metabolic pathways

214335_at RPL18 ribosomal protein L18 19 -53810399 AI669349 19q13 Hs.515517 16

RNA binding

structural constituent of ribosome

intracellular

cytoplasm

cytosol

ribosome

translational elongation

cytosolic large ribosomal subunit

Ribosome

225566_at NRP2 neuropilin 2 2 206255468, 206255468, 206255468 AI819729 2q33.3 Hs.471200 44

receptor activity

vascular endothelial growth factor receptor activity

membrane fraction

plasma membrane

cell adhesion

multicellular organismal development

nervous system development

axon guidance

integral to membrane

cell differentiation

 
1560573_at LOC387895 hypothetical gene supported by BC040060 12   BC040060 12q24.32 Hs.534660 1    
1555833_a_at IRGQ immunity-related GTPase family, Q 19 -48780358 AK096168 19q13.31 Hs.6217 5

protein binding

 
206770_s_at SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 1 100208127 NM_012243 1p21 Hs.448979 8

Golgi membrane

nucleotide-sugar transmembrane transporter activity

sugar:hydrogen symporter activity

UDP-N-acetylglucosamine transmembrane transporter activity

Golgi apparatus

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar transport

UDP-N-acetylglucosamine transport

membrane

integral to membrane

 
241525_at LOC200772 hypothetical protein LOC200772 2   AV700191 2q37.3 Hs.647893      
212372_at 0.903 7.144 2.992 9.015e-03 0.396 -2.468 MYH10 myosin, heavy chain 10, non-muscle 17 -8318254 AK026977 17p13 Hs.16355 37

microfilament motor activity

nucleotide binding

cytokinesis after mitosis

in utero embryonic development

stress fiber

neuron migration

plasma membrane repair

calmodulin binding

ATP binding

cytoplasm

spindle

plasma membrane

cell cortex

exocytosis

substrate-bound cell migration, cell extension

nuclear migration

axon guidance

brain development

adult heart development

biological_process

cell proliferation

regulation of cell shape

myosin complex

fourth ventricle development

lateral ventricle development

third ventricle development

cerebellar Purkinje cell layer development

actin cytoskeleton organization

actin filament-based movement

axon

growth cone

midbody

actin-dependent ATPase activity

neuron projection development

neuromuscular junction

cleavage furrow

cell soma

dendritic spine

ADP binding

neuromuscular process controlling balance

actin filament binding

cardiac myofibril assembly

ventricular cardiac muscle cell development

retina development in camera-type eye

Tight junction

Regulation of actin cytoskeleton

208835_s_at 0.413 9.471 2.384 3.055e-02 0.541 -3.497 LUC7L3 LUC7-like 3 (S. cerevisiae) 17 46151975 AW089673 17q21.33 Hs.130293 15

DNA binding

mRNA binding

protein binding

nucleus

mRNA processing

apoptosis

response to stress

RNA splicing

nuclear speck

 
1563863_x_at -0.248 4.451 -2.140 4.899e-02 0.590 -3.887 TCEANC transcription elongation factor A (SII) N-terminal and central domain containing X 13581227 AK097032 Xp22.2 Hs.222855 5

DNA binding

transcription elongation regulator activity

protein binding

nucleus

transcription

regulation of transcription from RNA polymerase II promoter

 
200812_at CCT7 chaperonin containing TCP1, subunit 7 (eta) 2 73314912 NM_006429 2p13.2 Hs.368149 18

nucleotide binding

ATP binding

cytoplasm

protein folding

unfolded protein binding

 
227634_at STK32C serine/threonine kinase 32C 10 -133870985 AW245946 10q26.3 Hs.469002 4

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

ATP binding

protein amino acid phosphorylation

transferase activity

 
1565325_at SNHG4 small nucleolar RNA host gene 4 (non-protein coding) 5 138637676 AJ224170 5q31.2 Hs.268939 5    
223911_at LOC440330 hypothetical protein LOC440330 16   BC004968 16p13.3 Hs.121180 1    
206868_at STARD8 StAR-related lipid transfer (START) domain containing 8 X 67784235, 67830217 NM_014725 Xq13.1 Hs.95140 8

GTPase activator activity

intracellular

focal adhesion

signal transduction

cell junction

 
236257_at CD2AP CD2-associated protein 6 47553483 AI244614 6p12 Hs.485518 37

ruffle

structural constituent of cytoskeleton

nucleolus

cytoplasm

plasma membrane

protein complex assembly

substrate-bound cell migration, cell extension

cell cycle

mitosis

signal transduction

beta-catenin binding

actin cytoskeleton

cell-cell adhesion

cell migration

SH3 domain binding

endocytic vesicle

filamentous actin

proteasomal ubiquitin-dependent protein catabolic process

cadherin binding

regulation of receptor-mediated endocytosis

perinuclear region of cytoplasm

cell division

 
229327_s_at -0.680 7.139 -2.391 3.013e-02 0.540 -3.485 MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 16 -78185246 BE674528 16q22-q23 Hs.134859 37

chromatin

cytokine production

transcription factor activity

RNA polymerase II transcription factor activity

protein binding

nucleus

cytoplasm

regulation of transcription, DNA-dependent

regulation of chondrocyte differentiation

sequence-specific DNA binding

positive regulation of transcription from RNA polymerase II promoter

cell development

lens fiber cell differentiation

 
203694_s_at DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 6 -30728885, -2069456, -1867754 NM_003587 6p21.3 Hs.485060 9

nucleotide binding

nucleic acid binding

RNA helicase activity

ATP binding

nucleus

mRNA processing

ATP-dependent helicase activity

RNA splicing

hydrolase activity

 
202353_s_at PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 17 -62767081, -62767080 NM_002816 17q24.2 Hs.646575 39

protein binding

cytosol

proteasome regulatory particle

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Proteasome

218649_x_at SDCCAG1 serologically defined colon cancer antigen 1 14 -49320281 NM_004713 14q22 Hs.655964 8

nucleus

cytoplasm

 
202057_at KPNA1 karyopherin alpha 1 (importin alpha 5) 3 -123623437 BC002374 3q21 Hs.161008 92

regulation of DNA recombination

protein binding

nucleus

nuclear pore

nucleoplasm

cytoplasm

cytosol

NLS-bearing substrate import into nucleus

intracellular protein transport

nuclear localization sequence binding

protein transporter activity

interspecies interaction between organisms

 
1570444_at LOC643201 hypothetical protein LOC643201 5   BC034407 5q35.2 Hs.390285 1    
206254_at EGF epidermal growth factor (beta-urogastrone) 4 111053488 NM_001963 4q25 Hs.419815 289

activation of MAPKK activity

angiogenesis

epidermal growth factor receptor binding

calcium ion binding

protein binding

extracellular region

extracellular space

plasma membrane

DNA replication

signal transduction

epidermal growth factor receptor signaling pathway

growth factor activity

integral to membrane

positive regulation of granule cell precursor proliferation

transmembrane receptor protein tyrosine kinase activator activity

platelet alpha granule lumen

positive regulation of phosphorylation

positive regulation of MAP kinase activity

positive regulation of epidermal growth factor receptor activity

positive regulation of mitosis

branching morphogenesis of a tube

regulation of protein secretion

regulation of peptidyl-tyrosine phosphorylation

negative regulation of secretion

MAPK signaling pathway

ErbB signaling pathway

Cytokine-cytokine receptor interaction

Endocytosis

Focal adhesion

Gap junction

Regulation of actin cytoskeleton

Pathways in cancer

Pancreatic cancer

Endometrial cancer

Glioma

Prostate cancer

Melanoma

Bladder cancer

Non-small cell lung cancer

224963_at SLC26A2 solute carrier family 26 (sulfate transporter), member 2 5 149320492 AK025078 5q31-q34 Hs.302738 24

transporter activity

membrane fraction

integral to plasma membrane

transport

secondary active sulfate transmembrane transporter activity

sulfate transport

membrane

 
209145_s_at CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 20 31541588, 31613831 AF068266 20q11 Hs.153934 19

transcription factor activity

transcription corepressor activity

protein binding

nucleus

zinc ion binding

epithelial cell differentiation

negative regulation of transcription, DNA-dependent

metal ion binding

 
226764_at ZNF827 zinc finger protein 827 4 -146901337 BG542955 4q31.21-q31.22 Hs.133916 Hs.633543 7

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
208115_x_at C10orf137 chromosome 10 open reading frame 137 10 127398073 NM_030897 10q26.13 Hs.468688 4

nucleus

regulation of transcription

 
225659_at SPOPL speckle-type POZ protein-like 2 138975819 BF516590 2q22.1 Hs.333297 6

protein binding

nucleus

modification-dependent protein catabolic process

 
215266_at DNAH3 dynein, axonemal, heavy chain 3 16 -20851976 AL096732 16p12.3 Hs.526500 7

nucleotide binding

ciliary or flagellar motility

microtubule motor activity

ATP binding

axonemal dynein complex

microtubule

cilium

microtubule-based movement

ATPase activity

cilium axoneme

Huntington's disease

226293_at 0.335 6.221 2.971 9.410e-03 0.401 -2.504 MED19 mediator complex subunit 19 11 -57227762 BE781103 11q12.1 Hs.43619 9

protein binding

nucleus

regulation of transcription from RNA polymerase II promoter

RNA polymerase II transcription mediator activity

regulation of transcription

 
230619_at 0.358 6.369 3.650 2.323e-03 0.283 -1.314 ARNT aryl hydrocarbon receptor nuclear translocator 1 -149048809 AI768497 1q21 Hs.632446 88

response to hypoxia

positive regulation of endothelial cell proliferation

RNA polymerase II transcription factor activity, enhancer binding

transcription coactivator activity

signal transducer activity

nucleus

regulation of transcription, DNA-dependent

signal transduction

positive regulation vascular endothelial growth factor production

aryl hydrocarbon receptor binding

positive regulation of vascular endothelial growth factor receptor signaling pathway

mRNA transcription from RNA polymerase II promoter

positive regulation of gene-specific transcription

sequence-specific DNA binding

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

positive regulation of erythrocyte differentiation

positive regulation of glycolysis

positive regulation of hormone biosynthetic process

protein heterodimerization activity

Pathways in cancer

Renal cell carcinoma

1569300_at MFAP3L microfibrillar-associated protein 3-like 4 -171144322, -171144322 BG718733 4q32.3 Hs.593942 3

plasma membrane

integral to membrane

 
217543_s_at MBTPS1 membrane-bound transcription factor peptidase, site 1 16 -82644869 BE890314 16 16q24 Hs.75890 24

serine-type endopeptidase activity

calcium ion binding

nucleus

endoplasmic reticulum

endoplasmic reticulum lumen

Golgi apparatus

Golgi stack

proteolysis

lipid metabolic process

steroid metabolic process

cholesterol metabolic process

peptidase activity

membrane

integral to membrane

regulation of transcription factor import into nucleus

 
1553316_at GPR82 G protein-coupled receptor 82 X 41468351 NM_080817 Xp11.4 Hs.664795 4

receptor activity

G-protein coupled receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

integral to membrane

 
231675_s_at ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 4 -100263855 AV650931 4q21-q24 4q22 Hs.1219 30

NADPH:quinone reductase activity

alcohol dehydrogenase activity, zinc-dependent

aldehyde reductase activity

retinol dehydrogenase activity

binding

all-trans retinal binding

cellular_component

cytoplasm

ethanol oxidation

cellular aldehyde metabolic process

zinc ion binding

oxidoreductase activity

benzaldehyde dehydrogenase activity

retinol binding

quinone cofactor metabolic process

retinol metabolic process

alcohol catabolic process

metal ion binding

NAD or NADH binding

oxidation reduction

Glycolysis / Gluconeogenesis

Fatty acid metabolism

Tyrosine metabolism

1- and 2-Methylnaphthalene degradation

3-Chloroacrylic acid degradation

Retinol metabolism

Metabolism of xenobiotics by cytochrome P450

Drug metabolism - cytochrome P450

Metabolic pathways

205972_at SLC38A3 solute carrier family 38, member 3 3 50217695 NM_006841 3p21.3 Hs.76460 16

L-histidine transmembrane transporter activity

plasma membrane

integral to plasma membrane

ion transport

sodium ion transport

amino acid transport

asparagine transport

glutamine transport

L-alanine transmembrane transporter activity

L-asparagine transmembrane transporter activity

L-glutamine transmembrane transporter activity

symporter activity

antiporter activity

L-alanine transport

histidine transport

sodium ion binding

 
224215_s_at DLL1 delta-like 1 (Drosophila) 6 -170433218 AF196571 6q27 Hs.379912 42

cell fate determination

somite specification

Notch binding

calcium ion binding

protein binding

extracellular region

plasma membrane

integral to plasma membrane

cell communication

Notch signaling pathway

multicellular organismal development

determination of left/right symmetry

compartment specification

hemopoiesis

regulation of cell adhesion

cytoplasmic vesicle

negative regulation of cell differentiation

negative regulation of auditory receptor cell differentiation

inner ear development

Notch signaling pathway

228420_at -0.239 5.780 -2.935 1.012e-02 0.415 -2.566 PDCD2 programmed cell death 2 6 -170732759, -170728374 AW590850 6q27 Hs.367900 14

DNA binding

protein binding

nucleus

cytoplasm

apoptosis

zinc ion binding

metal ion binding

 
202237_at 1.698 6.714 2.194 4.416e-02 0.579 -3.802 NNMT nicotinamide N-methyltransferase 11 113671744 NM_006169 11q23.1 Hs.503911 31

cytoplasm

nicotinamide N-methyltransferase activity

methyltransferase activity

transferase activity

Nicotinate and nicotinamide metabolism

Metabolic pathways

205235_s_at KIF20B kinesin family member 20B 10 91451346 NM_016195 10q23.31 Hs.240 10

nucleotide binding

microtubule motor activity

ATP binding

nucleus

nucleoplasm

nucleoplasm

nucleolus

nucleolus

cytoplasm

centrosome

centrosome

microtubule

microtubule-based movement

cell cycle

cell cycle arrest

regulation of mitosis

ATPase activity

ATPase activity

WW domain binding

WW domain binding

cell division

 
1553681_a_at PRF1 perforin 1 (pore forming protein) 10 -72027109 NM_005041 10q22 Hs.2200 88

calcium ion binding

apoptosis

cellular defense response

circadian rhythm

pathogenesis

membrane

integral to membrane

cytoplasmic membrane-bounded vesicle

cytolysis

response to ethanol

Natural killer cell mediated cytotoxicity

Type I diabetes mellitus

Autoimmune thyroid disease

Allograft rejection

Graft-versus-host disease

244840_x_at DOCK4 dedicator of cytokinesis 4 7 -111153399 AW452588 7q31.1 Hs.654652 16

guanyl-nucleotide exchange factor activity

protein binding

membrane

SH3 domain binding

PDZ domain binding

Rac GTPase activator activity

stereocilium

Rac GTPase binding

 
241990_at RHOV ras homolog gene family, member V 15 -38951704 BE547917 15q13.3 Hs.447901 7

nucleotide binding

magnesium ion binding

protein binding

GTP binding

intracellular

endosome

plasma membrane

small GTPase mediated signal transduction

 
218008_at C7orf42 chromosome 7 open reading frame 42 7 66023637 NM_017994 7q11.21 Hs.488478 5

membrane

integral to membrane

 
232593_at NEURL3 neuralized homolog 3 (Drosophila) pseudogene 2 -96527111 AL389981 2q11.2 Hs.149219 3

protein binding

zinc ion binding

ligase activity

modification-dependent protein catabolic process

metal ion binding

 
216055_at PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 22 -37949632, -37949632 AK022920 22q12.3-q13.1 22q13.1 Hs.1976 140

response to hypoxia

positive regulation of endothelial cell proliferation

monocyte chemotaxis

platelet-derived growth factor receptor binding

collagen binding

extracellular region

extracellular region

cytoplasm

substrate-bound cell migration

transforming growth factor beta receptor signaling pathway

growth factor activity

response to wounding

cell surface

negative regulation of phosphatidylinositol biosynthetic process

negative regulation of platelet activation

positive regulation of smooth muscle cell migration

membrane

cell growth

cell projection assembly

actin cytoskeleton organization

negative regulation of cell migration

platelet dense granule lumen

protein homodimerization activity

positive regulation of MAP kinase activity

cell surface binding

positive regulation of blood vessel endothelial cell migration

positive regulation of DNA replication

protein heterodimerization activity

platelet-derived growth factor receptor signaling pathway

positive regulation of fibroblast proliferation

platelet-derived growth factor binding

regulation of peptidyl-tyrosine phosphorylation

positive regulation of chemotaxis

cell chemotaxis

MAPK signaling pathway

Cytokine-cytokine receptor interaction

Focal adhesion

Gap junction

Regulation of actin cytoskeleton

Pathways in cancer

Renal cell carcinoma

Glioma

Prostate cancer

Melanoma

206147_x_at SCML2 sex comb on midleg-like 2 (Drosophila) X -18167353 NM_006089 Xp22 Hs.495774 7

transcription factor activity

nucleus

anatomical structure morphogenesis

regulation of transcription

 
211534_x_at PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 7 -157024510 U65065 7q36 Hs.490789 Hs.715864 Hs.716042 19

receptor activity

transmembrane receptor protein tyrosine phosphatase activity

protein binding

integral to plasma membrane

protein amino acid dephosphorylation

membrane

hydrolase activity

Type I diabetes mellitus

209168_at GPM6B glycoprotein M6B X -13702017, -13702017, -13698982 AW148844 Xp22.2 Hs.495710 17

molecular_function

multicellular organismal development

nervous system development

membrane

integral to membrane

cell differentiation

 
209621_s_at PDLIM3 PDZ and LIM domain 3 4 -186659844 AF002280 4q35 Hs.85862 12

nucleus

nucleolus

cytoplasm

actin filament organization

heart development

cytoskeletal protein binding

zinc ion binding

structural constituent of muscle

actin cytoskeleton

Z disc

metal ion binding

 
211469_s_at CXCR6 chemokine (C-X-C motif) receptor 6 3 45959976 U73531 3p21 Hs.34526 37

G-protein coupled receptor activity

plasma membrane

integral to plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

coreceptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity

viral genome replication

Cytokine-cytokine receptor interaction

Chemokine signaling pathway

223026_s_at 0.264 10.108 2.199 4.371e-02 0.578 -3.793 VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 12 -109413712 AF201946 12q24 Hs.600114 17

phosphoserine phosphatase activity

cytoplasm

endosome

zinc ion binding

protein transport

membrane

hydrolase activity

metal ion binding

 
213733_at MYO1F myosin IF 19 -8491996 BF740152 19p13.3-p13.2 Hs.465818 11

nucleotide binding

motor activity

actin binding

calmodulin binding

ATP binding

negative regulation of cell adhesion

biological_process

unconventional myosin complex

positive regulation of cell migration

cortical actin cytoskeleton

filamentous actin

regulation of actin cytoskeleton organization

neutrophil degranulation

regulation of innate immune response

defense response to Gram-positive bacterium

 
220529_at FLJ11710 hypothetical protein FLJ11710 17   NM_024846 17q23.2 Hs.657294 1    
227251_at DCAF5 DDB1 and CUL4 associated factor 5 14 -68587390 AI431597 14q23-q24.1 Hs.509780 6    
227256_at USP31 ubiquitin specific peptidase 31 16 -22980228 BG289456 16p12.2 Hs.183817 8

ubiquitin thiolesterase activity

ubiquitin-dependent protein catabolic process

peptidase activity

cysteine-type peptidase activity

 
1553718_at ZNF548 zinc finger protein 548 19 62593029 NM_152909 19q13.43 Hs.657353 3

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
225951_s_at 0.380 8.993 2.333 3.374e-02 0.552 -3.579 CHD2 chromodomain helicase DNA binding protein 2 15 91244554, 91244554 AV756026 15q26 Hs.220864 9

nucleotide binding

chromatin

DNA binding

chromatin binding

ATP-dependent DNA helicase activity

helicase activity

ATP binding

nucleus

chromatin assembly or disassembly

regulation of transcription from RNA polymerase II promoter

hydrolase activity

 
208218_s_at ACVR1B activin A receptor, type IB 12 50631752, 50631752, 50631752 NM_020328 12q13 Hs.438918 39

G1/S transition of mitotic cell cycle

nucleotide binding

magnesium ion binding

in utero embryonic development

hair follicle development

protein serine/threonine kinase activity

receptor activity

ATP binding

integral to plasma membrane

induction of apoptosis

signal transduction

transmembrane receptor protein serine/threonine kinase signaling pathway

embryonic development

cell surface

membrane

activin receptor activity, type I

transferase activity

peptidyl-threonine phosphorylation

growth factor binding

manganese ion binding

negative regulation of cell growth

ubiquitin protein ligase binding

positive regulation of activin receptor signaling pathway

regulation of transcription

positive regulation of erythrocyte differentiation

SMAD binding

protein amino acid autophosphorylation

activin binding

MAPK signaling pathway

Cytokine-cytokine receptor interaction

Endocytosis

TGF-beta signaling pathway

Adherens junction

Pathways in cancer

Colorectal cancer

Pancreatic cancer

Chronic myeloid leukemia

228369_at CNPY3 canopy 3 homolog (zebrafish) 6 43004837 AI262560 6pter-p12.1 Hs.414099 6

receptor binding

extracellular region

 
201172_x_at 0.251 9.756 2.845 1.215e-02 0.426 -2.721 ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 5 172343368 NM_003945 5q35.1 Hs.484188 18

transporter activity

membrane fraction

ion transport

vacuolar acidification

ATP synthesis coupled proton transport

ATP hydrolysis coupled proton transport

proton transport

membrane

integral to membrane

cell growth

hydrolase activity

proton-transporting V-type ATPase, V0 domain

ATPase activity, coupled to transmembrane movement of ions

proton-transporting ATPase activity, rotational mechanism

Oxidative phosphorylation

Metabolic pathways

Vibrio cholerae infection

Epithelial cell signaling in Helicobacter pylori infection

244759_x_at RNF207 ring finger protein 207 1 6188775 AI219323 1p36.31 Hs.716549 7

protein binding

intracellular

zinc ion binding

metal ion binding

 
208055_s_at HERC4 hect domain and RLD 4 10 -69351661 NM_015601 10q21.3 Hs.51891 7

intracellular

cytoplasm

cytosol

protein modification process

ligase activity

acid-amino acid ligase activity

modification-dependent protein catabolic process

Ubiquitin mediated proteolysis

216903_s_at CBARA1 calcium binding atopy-related autoantigen 1 10 -73797103 AK022697 10q22.1 Hs.524367 7

calcium ion binding

intracellular

defense response

membrane

integral to membrane

 
231228_at BCL2L1 BCL2-like 1 20 -29715921 AW263226 20q11.21 Hs.516966 295

release of cytochrome c from mitochondria

nucleus

mitochondrion

mitochondrial outer membrane

mitochondrial outer membrane

anti-apoptosis

negative regulation of survival gene product expression

membrane

integral to membrane

response to cytokine stimulus

identical protein binding

regulation of mitochondrial membrane permeability

regulation of mitochondrial membrane potential

Apoptosis

Jak-STAT signaling pathway

Amyotrophic lateral sclerosis (ALS)

Pathways in cancer

Pancreatic cancer

Chronic myeloid leukemia

Small cell lung cancer

210616_s_at 0.320 8.298 2.245 4.001e-02 0.568 -3.720 SEC31A SEC31 homolog A (S. cerevisiae) 4 -83958837 AB020712 4q21.22 Hs.370024 20

cytoplasm

endoplasmic reticulum

ER to Golgi vesicle-mediated transport

ER to Golgi vesicle-mediated transport

protein transport

membrane

membrane organization

vesicle-mediated transport

COPII vesicle coat

cytoplasmic vesicle

calcium-dependent protein binding

perinuclear region of cytoplasm

response to calcium ion

 
239894_at LOC100128511 hypothetical LOC100128511 10   AW204239 10p12.31        
209305_s_at GADD45B growth arrest and DNA-damage-inducible, beta 19 2427134 AF078077 19p13.3 Hs.110571 33

activation of MAPKKK activity

activation of MAPKK activity

protein binding

negative regulation of protein kinase activity

apoptosis

response to stress

multicellular organismal development

cell differentiation

regulation of cell cycle

MAPK signaling pathway

Cell cycle

p53 signaling pathway

227109_at CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 11 -14856131 AV700558 11p15.2 Hs.371427 13

monooxygenase activity

endoplasmic reticulum

microsome

electron carrier activity

membrane

heme binding

metal ion binding

cholestanetriol 26-monooxygenase activity

oxidation reduction

 
220004_at DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 6 74161005 NM_018665 6q12-q13 Hs.125507 12

nucleotide binding

RNA binding

ATP-dependent RNA helicase activity

helicase activity

ATP binding

intracellular

hydrolase activity

 
217173_s_at LDLR low density lipoprotein receptor 19 11061056 S70123 19p13.3 Hs.213289 Hs.713967 374

transmembrane receptor activity

low-density lipoprotein receptor activity

calcium ion binding

endosome

plasma membrane

plasma membrane

integral to plasma membrane

coated pit

protein amino acid O-linked glycosylation

lipid metabolic process

lipid transport

endocytosis

steroid metabolic process

cholesterol metabolic process

endosome membrane

very-low-density lipoprotein receptor activity

intestinal cholesterol absorption

clathrin-coated endocytic vesicle membrane

low-density lipoprotein particle

low-density lipoprotein particle clearance

lipoprotein catabolic process

cholesterol homeostasis

interspecies interaction between organisms

Endocytosis

227205_at TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa X 70502838 AW575233 Xq13.1 Hs.158560 110

G1 phase of mitotic cell cycle

regulation of transcription during G2/M-phase of mitotic cell cycle

nucleotide binding

p53 binding

transcription coactivator activity

histone acetyltransferase activity

protein serine/threonine kinase activity

ATP binding

nucleus

nucleoplasm

transcription factor TFIID complex

nucleolus

regulation of transcription, DNA-dependent

RNA elongation from RNA polymerase II promoter

cell cycle

transcription factor binding

positive regulation of specific transcription from RNA polymerase II promoter

promoter binding

kinase activity

transferase activity

transcription initiation factor activity

TATA-binding protein binding

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

cellular response to DNA damage stimulus

interspecies interaction between organisms

protein amino acid autophosphorylation

transcriptional preinitiation complex assembly

positive regulation of transcription initiation from RNA polymerase II promoter

histone acetyl-lysine binding

Basal transcription factors

230071_at SEPT11 septin 11 4 78089918 AI333326 4q21.1 Hs.128199 16

nucleotide binding

stress fiber

protein binding

GTP binding

cell cycle

septin complex

protein heterooligomerization

cell division

 
207355_at SLC1A7 solute carrier family 1 (glutamate transporter), member 7 1 -53325442 NM_006671 1p32.3 Hs.104637 Hs.716133 6

L-glutamate transmembrane transporter activity

transport

dicarboxylic acid transport

symporter activity

membrane

integral to membrane

sodium:dicarboxylate symporter activity

 
1556285_s_at PPA2 pyrophosphatase (inorganic) 2 4 -106509682 AF086012 4q25 Hs.654957 13

magnesium ion binding

inorganic diphosphatase activity

cytoplasm

mitochondrion

phosphate metabolic process

hydrolase activity

Oxidative phosphorylation

77508_r_at RABEP2 rabaptin, RAB GTPase binding effector protein 2 16 -28823242 AW001436 16p11.2 Hs.555978 6

GTPase activator activity

cytoplasm

early endosome

endocytosis

growth factor activity

protein transport

 
202691_at SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 18 17446257 NM_006938 18q11.2 Hs.464734 38

spliceosome assembly

spliceosomal snRNP biogenesis

RNA binding

protein binding

nucleus

nucleoplasm

spliceosomal complex

cytoplasm

cytosol

RNA splicing

small nuclear ribonucleoprotein complex

Systemic lupus erythematosus

244103_at C1orf55 chromosome 1 open reading frame 55 1 -224237025 AW963092 1q42.12 Hs.520192 2    
226676_at 0.657 4.388 4.757 2.451e-04 0.172 0.576 ZNF521 zinc finger protein 521 18 -20895885 AK021452 18q11.2 Hs.116935 9    
224413_s_at 0.330 7.148 2.289 3.679e-02 0.561 -3.651 TM2D2 TM2 domain containing 2 8 -38965483 AF353991 8p11.22 Hs.7471 5

membrane

integral to membrane

 
210399_x_at -0.284 6.170 -2.551 2.198e-02 0.499 -3.221 FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 19 -5781636 U27336 19p13.3 Hs.631846 Hs.705615 19

Golgi apparatus

protein amino acid glycosylation

membrane

integral to membrane

transferase activity, transferring glycosyl groups

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity

L-fucose catabolic process

alpha(1,3)-fucosyltransferase activity

Glycosphingolipid biosynthesis - lacto and neolacto series

Metabolic pathways

210039_s_at PRKCQ protein kinase C, theta 10 -6509110 L01087 10p15 Hs.498570 112

nucleotide binding

magnesium ion binding

regulation of cell growth

protein kinase C activity

protein binding

ATP binding

intracellular

protein amino acid phosphorylation

membrane protein ectodomain proteolysis

intracellular signaling cascade

zinc ion binding

transferase activity

diacylglycerol binding

Vascular smooth muscle contraction

Tight junction

T cell receptor signaling pathway

Adipocytokine signaling pathway

222735_at TMEM38B transmembrane protein 38B 9 107496645 AW452608 9q31.2 Hs.411925 5

potassium channel activity

endoplasmic reticulum

ion transport

potassium ion transport

membrane

integral to membrane

potassium ion binding

nuclear membrane

sarcoplasmic reticulum membrane

 
223037_at 0.493 7.586 2.867 1.163e-02 0.426 -2.684 PDZD11 PDZ domain containing 11 X -69422935 AF151061 Xq13.1 Hs.11042 12

protein binding

extracellular region

 
231854_at PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide 3 180349004 W63579 3q26.3 Hs.553498 Hs.85701 259

nucleotide binding

inositol or phosphatidylinositol kinase activity

ATP binding

cytosol

phosphoinositide 3-kinase complex

glucose metabolic process

protein amino acid phosphorylation

anti-apoptosis

signal transduction

1-phosphatidylinositol-3-kinase activity

transferase activity

phosphotransferase activity, alcohol group as acceptor

lamellipodium

regulation of multicellular organism growth

protein kinase B signaling cascade

insulin receptor substrate binding

phosphoinositide phosphorylation

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

phosphoinositide-mediated signaling

Inositol phosphate metabolism

ErbB signaling pathway

Chemokine signaling pathway

Phosphatidylinositol signaling system

mTOR signaling pathway

Apoptosis

VEGF signaling pathway

Focal adhesion

Toll-like receptor signaling pathway

Jak-STAT signaling pathway

Natural killer cell mediated cytotoxicity

T cell receptor signaling pathway

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Fc gamma R-mediated phagocytosis

Leukocyte transendothelial migration

Neurotrophin signaling pathway

Regulation of actin cytoskeleton

Insulin signaling pathway

Type II diabetes mellitus

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

Endometrial cancer

Glioma

Prostate cancer

Melanoma

Chronic myeloid leukemia

Acute myeloid leukemia

Small cell lung cancer

Non-small cell lung cancer

213346_at C13orf27 chromosome 13 open reading frame 27 13 -102216465 BE748563 13q33.1 Hs.398111 6    
235747_at SLC25A16 solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 10 -69912102 AI305170 10q21.3 Hs.180408 6

binding

mitochondrion

mitochondrial inner membrane

transport

solute:solute antiporter activity

membrane

integral to membrane

 
235810_at ZNF182 zinc finger protein 182 X -47719193 AI225224 Xp22.11-p11.23 Hs.189690 8

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
214805_at 0.472 5.588 3.638 2.381e-03 0.284 -1.335 EIF4A1 eukaryotic translation initiation factor 4A, isoform 1 17 7416780 U79273 17p13 Hs.129673 28

nucleotide binding

RNA cap binding

mRNA binding

translation initiation factor activity

helicase activity

protein binding

ATP binding

cytosol

translation

ATP-dependent helicase activity

eukaryotic translation initiation factor 4F complex

hydrolase activity

 
230425_at EPHB1 EPH receptor B1 3 135996949 AI674183 3q21-q23 Hs.116092 41

nucleotide binding

receptor activity

ephrin receptor activity

protein binding

ATP binding

plasma membrane

integral to plasma membrane

protein amino acid phosphorylation

signal transduction

transmembrane receptor protein tyrosine kinase signaling pathway

nervous system development

transferase activity

Axon guidance

233499_at LRRC7 leucine rich repeat containing 7 1 69998445 AI366175 1p31.1 Hs.479658 16

protein binding

nucleus

nucleolus

cytoplasm

plasma membrane

focal adhesion

 
208641_s_at RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 7 6380650 BC004247 7p22 Hs.413812 406

nucleotide binding

GTPase activity

GTP binding

intracellular

cytosol

plasma membrane

cell motion

inflammatory response

cell adhesion

small GTPase mediated signal transduction

anatomical structure morphogenesis

regulation of hydrogen peroxide metabolic process

positive regulation of lamellipodium assembly

enzyme binding

actin filament polymerization

GTP-dependent protein binding

ruffle organization

positive regulation of Rho protein signal transduction

melanosome

negative regulation of receptor-mediated endocytosis

localization within membrane

regulation of respiratory burst

MAPK signaling pathway

Chemokine signaling pathway

Wnt signaling pathway

Axon guidance

VEGF signaling pathway

Focal adhesion

Adherens junction

Toll-like receptor signaling pathway

Natural killer cell mediated cytotoxicity

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

Fc gamma R-mediated phagocytosis

Leukocyte transendothelial migration

Neurotrophin signaling pathway

Regulation of actin cytoskeleton

Amyotrophic lateral sclerosis (ALS)

Epithelial cell signaling in Helicobacter pylori infection

Pathways in cancer

Colorectal cancer

Renal cell carcinoma

Pancreatic cancer

204444_at KIF11 kinesin family member 11 10 94342804 NM_004523 10q24.1 Hs.8878 43

nucleotide binding

spindle pole

microtubule motor activity

ATP binding

kinesin complex

spindle microtubule

microtubule-based movement

cell cycle

mitotic spindle organization

mitosis

mitotic centrosome separation

chromatin remodeling complex

spindle pole body organization

cell division

 
223598_at RAD23B RAD23 homolog B (S. cerevisiae) 9 109085364 AF262027 9q31.2 Hs.521640 54

nucleotide-excision repair, DNA damage removal

damaged DNA binding

single-stranded DNA binding

protein binding

nucleus

nucleoplasm

cytoplasm

cytosol

response to DNA damage stimulus

modification-dependent protein catabolic process

proteasomal ubiquitin-dependent protein catabolic process

protein complex

Nucleotide excision repair

231978_at 0.379 3.703 3.009 8.694e-03 0.393 -2.437 TPCN2 two pore segment channel 2 11 68572925 AL137479 11q13.3 Hs.131851 9

voltage-gated ion channel activity

calcium channel activity

calcium ion binding

ion transport

calcium ion transport

membrane

integral to membrane

 
214060_at SSBP1 single-stranded DNA binding protein 1 7 141084644 BE220360 7q34 Hs.490394 21

DNA binding

single-stranded DNA binding

mitochondrion

DNA replication

mitochondrial nucleoid

positive regulation of helicase activity

DNA replication

Mismatch repair

Homologous recombination

219972_s_at C14orf135 chromosome 14 open reading frame 135 14 59628381 NM_022495 14q23.1 Hs.509499 7

membrane

integral to membrane

 
235900_at SPNS3 spinster homolog 3 (Drosophila) 17 4283967 AW016030 17p13.2 Hs.657543 2

lipid transport

membrane

integral to membrane

 
212236_x_at KRT17 keratin 17 17 -37029217 Z19574 17q12-q21 Hs.2785 39

structural constituent of cytoskeleton

protein binding

nucleus

nucleolus

cytoplasm

cytoskeleton

intermediate filament

epidermis development

 
1560514_at -0.265 3.903 -2.601 1.987e-02 0.491 -3.137 LOC285205 hypothetical LOC285205 3 109084741 BC039517 3q13.12 Hs.134882 2    
1557682_a_at RP11-297H3.4 hypothetical LOC284688 1 -168507169 BG150294 1q24.2 Hs.135668 2    
218848_at THOC6 THO complex 6 homolog (Drosophila) 16 3014032 NM_024339 16p13.3 Hs.412304 2    
226337_at GORAB golgin, RAB6-interacting 1 168767886, 168767886 AK021814 1q24.2 Hs.183702 7

protein binding

cytoplasm

Golgi apparatus

 
207676_at ONECUT2 one cut homeobox 2 18 53253914 NM_004852 18q21.1-q21.2 Hs.194725 7

liver development

regulation of cell-matrix adhesion

epithelial cell development

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

regulation of transcription, DNA-dependent

organ morphogenesis

positive regulation of cell migration

negative regulation of transforming growth factor beta receptor signaling pathway

endocrine pancreas development

cilium assembly

sequence-specific DNA binding

cell fate commitment

positive regulation of transcription from RNA polymerase II promoter

peripheral nervous system neuron development

 
206614_at -0.323 5.363 -3.324 4.553e-03 0.332 -1.887 GDF5 growth differentiation factor 5 20 -33484562 NM_000557 20q11.2 Hs.1573 58

cytokine activity

protein binding

extracellular region

extracellular space

transforming growth factor beta receptor signaling pathway

cell-cell signaling

growth factor activity

embryonic limb morphogenesis

positive regulation of chondrocyte differentiation

post-embryonic hindlimb morphogenesis

forelimb morphogenesis

growth

regulation of multicellular organism growth

regulation of apoptosis

Cytokine-cytokine receptor interaction

TGF-beta signaling pathway

1561589_a_at 0.328 2.975 2.746 1.485e-02 0.453 -2.891 NBEAL1 neurobeachin-like 1 2 203587846, 203708717 AB053319 2q33.2 Hs.604686 Hs.648846 6    
226703_at NEURL4 neuralized homolog 4 (Drosophila) 17 -7159674 AL136870 17p13 Hs.654794 3

protein binding

 
216442_x_at 0.943 9.123 3.371 4.131e-03 0.323 -1.804 FN1 fibronectin 1 2 -215987628, -215933423 AK026737 2q34 Hs.203717 291

extracellular matrix structural constituent

collagen binding

extracellular region

extracellular region

fibrinogen complex

proteinaceous extracellular matrix

ER-Golgi intermediate compartment

acute-phase response

cell adhesion

heparin binding

regulation of cell shape

response to wounding

cell migration

peptide cross-linking

platelet alpha granule lumen

substrate adhesion-dependent cell spreading

Focal adhesion

ECM-receptor interaction

Regulation of actin cytoskeleton

Pathways in cancer

Small cell lung cancer

230385_at MARCH3 membrane-associated ring finger (C3HC4) 3 5 -126231305 BF510835 5q23.2 Hs.132441 6

endosome

endocytosis

zinc ion binding

membrane

integral to membrane

ligase activity

modification-dependent protein catabolic process

cytoplasmic vesicle

metal ion binding

 
203906_at IQSEC1 IQ motif and Sec7 domain 1 3 -12913718, -12913718 AI652645 3p25.2 Hs.475506 10

ARF guanyl-nucleotide exchange factor activity

intracellular

nucleus

cytoplasm

regulation of ARF protein signal transduction

Endocytosis

234453_s_at C14orf166B chromosome 14 open reading frame 166B 14 76362477 AF111169 14q24.3 Hs.147276 2

protein binding

 
1552276_a_at -0.294 5.144 -2.254 3.932e-02 0.567 -3.706 VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) 15 38973919 NM_080432 15q14-q15 Hs.23876 11

actin binding

protein binding

lysosome

early endosome

actin filament

endosome organization

lysosome organization

zinc ion binding

protein transport

membrane

metal ion binding

 
221019_s_at COLEC12 collectin sub-family member 12 18 -309355 NM_030781 18pter-p11.3 Hs.464422 8

scavenger receptor activity

binding

calcium ion binding

sugar binding

galactose binding

phagocytosis, recognition

pattern recognition receptor activity

carbohydrate mediated signaling

membrane

integral to membrane

low-density lipoprotein binding

innate immune response

protein homooligomerization

 
213844_at HOXA5 homeobox A5 7 -27147520 NM_019102 7p15-p14 Hs.655218 32

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

pattern specification process

anterior/posterior pattern formation

lung development

thyroid gland development

multicellular organism growth

sequence-specific DNA binding

embryonic skeletal system morphogenesis

 
203130_s_at KIF5C kinesin family member 5C 2 149349288 NM_004522 2q23.1 Hs.435557 Hs.660699 15

nucleotide binding

microtubule motor activity

protein binding

ATP binding

kinesin complex

microtubule

organelle organization

microtubule-based movement

 
213311_s_at TCF25 transcription factor 25 (basic helix-loop-helix) 16 88467494 BF000251 16q24.3 Hs.415342 9

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

protein binding

nucleus

heart development

regulation of transcription

 
208660_at CS citrate synthase 12 -54951749 BC000105 12q13.2-q13.3 Hs.430606 Hs.715526 20

citrate (Si)-synthase activity

citrate (Si)-synthase activity

mitochondrion

mitochondrial matrix

mitochondrial matrix

tricarboxylic acid cycle

transferase activity

cellular carbohydrate metabolic process

Citrate cycle (TCA cycle)

Glyoxylate and dicarboxylate metabolism

Biosynthesis of phenylpropanoids

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from shikimate pathway

Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of alkaloids derived from terpenoid and polyketide

Biosynthesis of plant hormones

Metabolic pathways

210946_at PPAP2A phosphatidic acid phosphatase type 2A 5 -54756439 AF014403 5q11 Hs.696231 20

membrane fraction

cytosol

plasma membrane

integral to plasma membrane

activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway

phosphatidate phosphatase activity

phosphatidate phosphatase activity

phosphatidate phosphatase activity

negative regulation of cell proliferation

germ cell migration

hydrolase activity

regulation of lipid metabolic process

androgen receptor signaling pathway

phospholipid dephosphorylation

Glycerolipid metabolism

Glycerophospholipid metabolism

Ether lipid metabolism

Sphingolipid metabolism

Metabolic pathways

Fc gamma R-mediated phagocytosis

215275_at TRAF3IP3 TRAF3 interacting protein 3 1 207996146 AW963138 1q32.3-q41 Hs.147434 11

membrane

integral to membrane

 
1569469_a_at -0.268 2.348 -2.267 3.842e-02 0.565 -3.687 LHX8 LIM homeobox 8 1 75366706 BC040321 1p31.1 Hs.403934 8

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

learning or memory

zinc ion binding

female gonad development

forebrain neuron development

odontogenesis of dentine-containing tooth

sequence-specific DNA binding

metal ion binding

 
1555831_s_at LRRC41 leucine rich repeat containing 41 1 -46516658 BC004948 1p34.1 Hs.144941 12

modification-dependent protein catabolic process

 
204181_s_at ZBTB43 zinc finger and BTB domain containing 43 9 128607105 T90308 9q33-q34 Hs.355581 Hs.718657 7

DNA binding

protein binding

intracellular

nucleus

nucleolus

zinc ion binding

regulation of transcription

metal ion binding

 
201411_s_at PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2 131578889 NM_017958 2q21.1 Hs.469944 Hs.711433 11

protein binding

membrane

 
1553169_at LRRN4 leucine rich repeat neuronal 4 20 -5969424 BC019612 20p12.3 Hs.149133 Hs.716060 6

protein binding

membrane

integral to membrane

 
211296_x_at UBC ubiquitin C 12 -123962144 AB009010 12q24.3 Hs.520348 226  

PPAR signaling pathway

207810_at -0.192 2.717 -2.194 4.420e-02 0.579 -3.802 F13B coagulation factor XIII, B polypeptide 1 -195274943 NM_001994 1q31-q32.1 Hs.435782 43

extracellular region

extracellular region

blood coagulation

Complement and coagulation cascades

1553053_at -0.196 3.668 -2.305 3.563e-02 0.556 -3.624 C14orf48 chromosome 14 open reading frame 48 14 93533368, 93533394, 93533394 NM_152777 14q32.12 Hs.143845 5    
227441_s_at ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 12 -97662124, -97653201, -97653201 AW005572 12q23.1 Hs.506458 10

nucleus

cytoplasm

plasma membrane

postsynaptic density

Cajal body

cell junction

cell projection

dendritic spine

synapse

postsynaptic membrane

 
211677_x_at CADM3 cell adhesion molecule 3 1 157408000, 157408037 AF062733 1q21.2-q22 Hs.365689 16

calcium ion binding

protein binding

plasma membrane

cell-cell junction

cell adhesion

homophilic cell adhesion

heterophilic cell adhesion

integral to membrane

protein homodimerization activity

Cell adhesion molecules (CAMs)

224162_s_at FBXO31 F-box protein 31 16 -85920444, -85920444 BC002985 16q24.2 Hs.567582 10

cell cycle

cyclin catabolic process

SCF ubiquitin ligase complex

modification-dependent protein catabolic process

cyclin binding

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

G1 DNA damage checkpoint

cellular response to DNA damage stimulus

 
207036_x_at GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 19 53589943 NM_000836 19q13.1-qter Hs.445015 42

magnesium ion binding

startle response

receptor activity

N-methyl-D-aspartate selective glutamate receptor activity

ion channel activity

extracellular-glutamate-gated ion channel activity

calcium ion binding

protein binding

plasma membrane

ion transport

signal transduction

adult locomotory behavior

integral to membrane

synaptosome

cell junction

synapse

postsynaptic membrane

regulation of sensory perception of pain

Calcium signaling pathway

Neuroactive ligand-receptor interaction

Long-term potentiation

Alzheimer's disease

Amyotrophic lateral sclerosis (ALS)

221729_at 0.720 7.368 2.990 9.045e-03 0.396 -2.471 COL5A2 collagen, type V, alpha 2 2 -189604885 AL575735 2q14-q32 Hs.445827 29

molecular_function

extracellular matrix structural constituent

extracellular region

collagen

collagen type V

collagen fibril organization

collagen fibril organization

skin development

skin development

eye morphogenesis

Focal adhesion

ECM-receptor interaction

226037_s_at TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa X -77271900, 1383006 AL049589 Xq13.1-q21.1 Hs.592248 Hs.643614 Hs.714006 8

DNA binding

transcription corepressor activity

protein binding

nucleus

transcription factor TFIID complex

transcription initiation

negative regulation of specific transcription from RNA polymerase II promoter

positive regulation of cell growth

transcription factor TFTC complex

negative regulation of apoptosis

regulation of transcription

Basal transcription factors

239831_at TMEM106C transmembrane protein 106C 12 46643596 R19392 12q13.1 Hs.596726 5

molecular_function

cellular_component

endoplasmic reticulum

biological_process

membrane

integral to membrane

 
229328_at ZNF540 zinc finger protein 540 19 42734147 T90358 19q13.12 Hs.121283 5

DNA binding

intracellular

nucleus

nucleolus

cytoplasm

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
212172_at -0.289 5.354 -2.211 4.275e-02 0.576 -3.775 AK2 adenylate kinase 2 1 -33251169, -33246172 AW277253 1p34 Hs.470907 16

nucleotide binding

adenylate kinase activity

ATP binding

mitochondrion

mitochondrial intermembrane space

mitochondrial intermembrane space

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

transferase activity

nucleoside kinase activity

Purine metabolism

Metabolic pathways

225868_at TRIM47 tripartite motif-containing 47 17 -71381839 AW249467 17q24-q25 Hs.293660 5

protein binding

intracellular

nucleus

cytoplasm

zinc ion binding

metal ion binding

 
1557055_s_at 0.819 6.704 3.198 5.896e-03 0.357 -2.107 LOC643837 hypothetical LOC643837 1 752926 BC042880 1p36.33 Hs.133183 2    
234107_s_at DTD1 D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae) 20 18516555 AL121780 20p11.23 Hs.659442 7

cytoplasm

hydrolase activity, acting on ester bonds

D-amino acid catabolic process

 
227986_at ZNF343 zinc finger protein 343 20 -2410466 AW014719 20p13 Hs.516846 4

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
241999_at SFXN5 sideroflexin 5 2 -73022672 AA725691   Hs.368171 6

iron ion binding

mitochondrion

mitochondrial inner membrane

cation transport

iron ion transport

cation transmembrane transporter activity

membrane

integral to membrane

 
220009_at LONRF3 LON peptidase N-terminal domain and ring finger 3 X 117992740 NM_024778 Xq24 Hs.144266 6

ATP-dependent peptidase activity

protein binding

proteolysis

zinc ion binding

metal ion binding

 
205749_at CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 15 -72798935 NM_000499 15q24.1 Hs.72912 612

endoplasmic reticulum

microsome

electron carrier activity

membrane

drug metabolic process

oxygen binding

heme binding

vitamin D metabolic process

metal ion binding

oxidation reduction

aromatase activity

vitamin D 24-hydroxylase activity

Tryptophan metabolism

Retinol metabolism

Metabolism of xenobiotics by cytochrome P450

218680_x_at C15orf63 chromosome 15 open reading frame 63 15 41879912 NM_016400 15q15.3 Hs.631692 6

protein binding

 
234486_at -0.360 5.275 -2.566 2.133e-02 0.497 -3.196 OR51B2 olfactory receptor, family 51, subfamily B, member 2 11 -5301103 AF137396 11p15 Hs.680163 4

receptor activity

olfactory receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

sensory perception of smell

integral to membrane

response to stimulus

Olfactory transduction

213778_x_at ZNF276 zinc finger protein 276 16 88314893, 88315452 AI983201 16q24.3 Hs.290154 8

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
244477_at SLC12A3 solute carrier family 12 (sodium/chloride transporters), member 3 16 55456619 AW292635 16q13 Hs.669115 52

transporter activity

membrane fraction

integral to plasma membrane

ion transport

sodium ion transport

chloride transport

symporter activity

sodium:chloride symporter activity

membrane

apical plasma membrane

sodium ion binding

 
217335_at FLJ11292 hypothetical protein FLJ11292 5   AK023539 5q14.3 Hs.677194 Hs.719629 2    
222116_s_at 0.367 5.189 2.339 3.340e-02 0.552 -3.571 TBC1D16 TBC1 domain family, member 16 17 -75528413 AL157485 17q25.3 Hs.369819 4

GTPase activator activity

Rab GTPase activator activity

intracellular

regulation of Rab GTPase activity

 
221637_s_at C11orf48 chromosome 11 open reading frame 48 11 -62186864 BC001434 11q12.3 Hs.9061 3    
1554486_a_at -0.257 2.623 -2.550 2.200e-02 0.499 -3.222 C6orf114 chromosome 6 open reading frame 114 6 -13577487 BC009205 6p23 Hs.674313 3    
209091_s_at 0.209 9.414 2.155 4.759e-02 0.586 -3.863 SH3GLB1 SH3-domain GRB2-like endophilin B1 1 86942844 AF263293 1p22 Hs.136309 28

protein insertion into mitochondrial membrane during induction of apoptosis

fatty acid binding

protein binding

nucleus

cytoplasm

mitochondrion

mitochondrial outer membrane

microsome

Golgi apparatus

phosphatidic acid biosynthetic process

apoptosis

anti-apoptosis

phospholipid biosynthetic process

membrane

lysophosphatidic acid acyltransferase activity

protein homodimerization activity

protein complex

'de novo' posttranslational protein folding

Endocytosis

227100_at -0.575 5.464 -3.274 5.049e-03 0.345 -1.975 B3GALTL beta 1,3-galactosyltransferase-like 13 30672111 AI569766 13q12.3 Hs.13205 11

endoplasmic reticulum

carbohydrate metabolic process

fucose metabolic process

membrane

integral to membrane

transferase activity, transferring glycosyl groups

 
204141_at 0.824 7.991 2.625 1.895e-02 0.488 -3.097 TUBB2A tubulin, beta 2A 6 -3098900 NM_001069 6p25 Hs.654543 74

nucleotide binding

GTPase activity

structural molecule activity

protein binding

GTP binding

microtubule

microtubule-based movement

protein complex

protein polymerization

Gap junction

Pathogenic Escherichia coli infection - EHEC

206463_s_at DHRS2 dehydrogenase/reductase (SDR family) member 2 14 23175412 NM_005794 14q11.2 Hs.272499 12

carbonyl reductase (NADPH) activity

binding

nucleus

nuclear envelope

cytoplasm

C21-steroid hormone metabolic process

negative regulation of cell proliferation

response to toxin

oxidoreductase activity

myeloid dendritic cell differentiation

oxidation reduction

 
1569905_at HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like 19 5632034, 5632046, 5632051, 5632074 BC018336 19p13.3 Hs.631840 2

binding

extracellular region

oxidoreductase activity

oxidation reduction

 
213513_x_at ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 2 218790118, 218790364 BG034239 2q36.1 Hs.529303 23

actin binding

structural constituent of cytoskeleton

protein binding

cytoplasm

Golgi apparatus

Arp2/3 protein complex

focal adhesion

cell motion

positive regulation of actin filament polymerization

cell leading edge

cell projection

Fc gamma R-mediated phagocytosis

Regulation of actin cytoskeleton

212368_at ZNF292 zinc finger protein 292 6 87921987 AA972711 6q14.3 Hs.485892 Hs.656621 7

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
225998_at GAB1 GRB2-associated binding protein 1 4 144477432 AK022142 4q31.21 Hs.618456 Hs.80720 69

SH3/SH2 adaptor activity

protein binding

cytosol

epidermal growth factor receptor signaling pathway

cell proliferation

insulin receptor signaling pathway

ErbB signaling pathway

Neurotrophin signaling pathway

Renal cell carcinoma

211686_s_at MAK16 MAK16 homolog (S. cerevisiae) 8 33462226 AF251062 8p12 Hs.583805 10

nucleus

nucleolus

 
37201_at ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) 3 -52822045 D38535 3p21-p14 Hs.709406 19

serine-type endopeptidase inhibitor activity

extracellular region

acute-phase response

hyaluronan metabolic process

 
231672_at CES4 carboxylesterase 4-like 16 54352011 AV648327 16q12.2 Hs.535486 2

carboxylesterase activity

extracellular region

endoplasmic reticulum

anatomical structure morphogenesis

 
207306_at TCF15 transcription factor 15 (basic helix-loop-helix) 20 -532636 NM_004609 20p13 Hs.437 4

somitogenesis

respiratory system process

transcription factor activity

RNA polymerase II transcription factor activity

nucleus

regulation of transcription from RNA polymerase II promoter

multicellular organismal development

death

tail morphogenesis

eating behavior

ear development

skin development

regulation of transcription

paraxial mesoderm development

muscle organ morphogenesis

skeletal system morphogenesis

neuromuscular process controlling posture

 
232402_at LOC643696 hypothetical LOC643696 15   AI205683 15q25.2 Hs.454625 Hs.513947      
202842_s_at DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 7 107997591 AL080081 14q24.2-q24.3 7q31 Hs.6790 16

nucleus

nucleolus

cytoplasm

endoplasmic reticulum

protein folding

heat shock protein binding

unfolded protein binding

 
239471_at -0.379 3.369 -2.671 1.728e-02 0.471 -3.019 LRRC28 leucine rich repeat containing 28 15 97609174 AW409674 15q26.3 Hs.578684 4

protein binding

 
216178_x_at 0.598 7.325 2.157 4.744e-02 0.585 -3.861 ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 10 -33236244, -33229251, -33229251, -33229251 AA215854 10p11.2 Hs.643813 512

G1/S transition of mitotic cell cycle

in utero embryonic development

cell fate specification

receptor activity

integrin binding

focal adhesion

cellular defense response

cell adhesion

homophilic cell adhesion

leukocyte adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

positive regulation of cell proliferation

integrin complex

germ cell migration

cell surface

integral to membrane

synaptosome

B cell differentiation

neuromuscular junction

ruffle membrane

cell-cell adhesion mediated by integrin

sarcolemma

melanosome

identical protein binding

interspecies interaction between organisms

sarcomere organization

negative regulation of cell differentiation

protein heterodimerization activity

regulation of cell cycle

cardiac muscle cell differentiation

Axon guidance

Focal adhesion

ECM-receptor interaction

Cell adhesion molecules (CAMs)

Leukocyte transendothelial migration

Regulation of actin cytoskeleton

Pathogenic Escherichia coli infection - EHEC

Pathways in cancer

Small cell lung cancer

Hypertrophic cardiomyopathy (HCM)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

216893_s_at COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 2 227737524 U02519 2q36-q37 Hs.570065 77

integrin binding

integrin binding

extracellular matrix structural constituent

protein binding

extracellular region

collagen

collagen type IV

induction of apoptosis

activation of caspase activity

cell adhesion

cell surface receptor linked signal transduction

sensory perception of sound

blood circulation

metalloendopeptidase inhibitor activity

negative regulation of cell proliferation

negative regulation of angiogenesis

 
221796_at 0.804 3.411 2.631 1.872e-02 0.487 -3.086 NTRK2 neurotrophic tyrosine kinase, receptor, type 2 9 86473285, 86474414, 86474445 AA707199 9q22.1 Hs.494312 Hs.712776 111

nucleotide binding

vasculogenesis

transmembrane receptor protein tyrosine kinase activity

neurotrophin receptor activity

protein binding

ATP binding

cytosol

plasma membrane

integral to plasma membrane

activation of adenylate cyclase activity

multicellular organismal development

nervous system development

feeding behavior

cell surface

glutamate secretion

postsynaptic density

transferase activity

regulation of metabolic process

axon

dendrite

growth cone

brain-derived neurotrophic factor receptor signaling pathway

mechanoreceptor differentiation

cell soma

terminal button

retinal rod cell development

protein amino acid autophosphorylation

regulation of neurotransmitter secretion

brain-derived neurotrophic factor binding

presynaptic active zone

regulation of dendrite development

positive regulation of synaptic transmission, glutamatergic

excitatory synapse

MAPK signaling pathway

Neurotrophin signaling pathway

228046_at ZNF827 zinc finger protein 827 4 -146901337 AA741243 4q31.21-q31.22 Hs.133916 Hs.633543 7

DNA binding

intracellular

nucleus

zinc ion binding

regulation of transcription

metal ion binding

 
1561537_at -0.283 5.817 -2.581 2.069e-02 0.497 -3.170 LOC388906 hypothetical protein LOC388906 22   BC039496 22q13.2 Hs.679422 1    
217114_at LOC652147 similar to U5 snRNP-specific protein, 200 kDa Un   Z70200          
201192_s_at PITPNA phosphatidylinositol transfer protein, alpha 17 -1368032 NM_006224 17p13.3 Hs.429819 18

protein binding

phospholipid binding

intracellular

nucleus

cytoplasm

lipid metabolic process

transport

visual perception

phosphatidylcholine transmembrane transporter activity

phosphatidylinositol transporter activity

 
213819_s_at -0.322 5.071 -3.544 2.889e-03 0.297 -1.500 FLOT1 flotillin 1 6 -30803489, -2144083, -1942389 H45696 6p21.3 Hs.179986 36

protein binding

Golgi apparatus

microtubule organizing center

plasma membrane

integral to membrane

flotillin complex

centriolar satellite

melanosome

Insulin signaling pathway

208136_s_at MGC3771 hypothetical LOC81854 16 -3100462 NM_030970 16p13.3 Hs.669490 1    
207848_at AVP arginine vasopressin 20 -3011201 NM_000490 20p13 Hs.89648 85

neurohypophyseal hormone activity

extracellular region

soluble fraction

generation of precursor metabolites and energy

water transport

signal transduction

cell-cell signaling

vasoconstriction

 
207763_at S100A5 S100 calcium binding protein A5 1 -151776246 NM_002962 1q21 Hs.2960 10

calcium ion binding

 
1559624_at STK32A serine/threonine kinase 32A 5 146594771, 146594771 AK094580 5q32 Hs.585069 6

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

ATP binding

protein amino acid phosphorylation

transferase activity

 
231357_at CLEC12B C-type lectin domain family 12, member B 12 10054497, 10054497 AW003535 12p13.2 Hs.127937 3

receptor activity

binding

sugar binding

plasma membrane

integral to membrane

 
206030_at ASPA aspartoacylase (Canavan disease) 17 3324153, 3326045 NM_000049 17pter-p13 Hs.171142 27

aminoacylase activity

nucleus

cytoplasm

aspartate catabolic process

metabolic process

zinc ion binding

hydrolase activity, acting on ester bonds

aspartoacylase activity

metal ion binding

Alanine, aspartate and glutamate metabolism

Histidine metabolism

227033_at PDIA3 protein disulfide isomerase family A, member 3 15 41825881 AI825800 15q15 Hs.591095 72

protein disulfide isomerase activity

cysteine-type endopeptidase activity

phospholipase C activity

protein binding

endoplasmic reticulum

endoplasmic reticulum lumen

protein import into nucleus

protein retention in ER lumen

signal transduction

isomerase activity

melanosome

positive regulation of apoptosis

cell redox homeostasis

Antigen processing and presentation

206735_at CHRNA4 cholinergic receptor, nicotinic, alpha 4 20 -61445108 NM_000744 20q13.2-q13.3 Hs.10734 90

regulation of action potential

response to hypoxia

nicotinic acetylcholine-activated cation-selective channel activity

ion channel activity

extracellular ligand-gated ion channel activity

membrane fraction

plasma membrane

nicotinic acetylcholine-gated receptor-channel complex

DNA repair

ion transport

calcium ion transport

response to oxidative stress

signal transduction

synaptic transmission, cholinergic

external side of plasma membrane

regulation of dopamine secretion

acetylcholine receptor activity

integral to membrane

sensory perception of pain

cell junction

dendrite

behavioral response to nicotine

B cell activation

cell soma

synapse

postsynaptic membrane

cognition

membrane depolarization

regulation of inhibitory postsynaptic membrane potential

 
1553163_at ADPRHL1 ADP-ribosylhydrolase like 1 13 -113124584, -113124260 NM_138430 13q34 Hs.98669 4

magnesium ion binding

ADP-ribosylarginine hydrolase activity

hydrolase activity

protein amino acid de-ADP-ribosylation

 
231812_x_at PHAX phosphorylated adaptor for RNA export 5 125964531 AK023255 5q23.2 Hs.555731 Hs.719165 10

spliceosomal snRNP biogenesis

RNA binding

protein binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytosol

snRNA export from nucleus

Cajal body

protein transport

 
210658_s_at -0.329 5.965 -2.624 1.900e-02 0.488 -3.099 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 16 -23383143 BC000284 16p12 Hs.460336 37

protein binding

intracellular

endosome

trans-Golgi network

intracellular protein transport

membrane

vesicle-mediated transport

membrane coat

clathrin adaptor complex

ADP-ribosylation factor binding

Lysosome

228753_at 0.558 5.109 2.768 1.422e-02 0.446 -2.854 LOC100128737 hypothetical LOC100128737 7   AI041217 7q22.3        
225551_at C1orf71 chromosome 1 open reading frame 71 1 244796261, 244796261 AW291187 1q44 Hs.368353 9

membrane

integral to membrane

protein complex

 
1553067_a_at GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2 1 -144221176 NM_057163 1q12 Hs.711567 Hs.714903 12

receptor activity

G-protein coupled receptor activity

gonadotropin-releasing hormone receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

integral to membrane

 
236042_at LOC100130219 similar to hCG2041987 12   AI700506 12p13.33 Hs.410355 1    
224308_s_at INTS2 integrator complex subunit 2 17 -57297511 AL136800 17q23.2 Hs.279646 7

protein binding

intracellular

nucleus

membrane

integral to membrane

snRNA processing

integrator complex

 
226778_at C8orf42 chromosome 8 open reading frame 42 8 -431645 AI632224 8p23.3 Hs.289293 1    
226990_at CAPRIN1 cell cycle associated protein 1 11 34029805, 34029805 AI798775 11p13 Hs.471818 10

protein binding

cytoplasm

cytosol

integral to plasma membrane

dendrite

cell projection

 
208480_s_at ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 16 -16222544, -16150922 NM_001171 16p13.1 Hs.442182 70

nucleotide binding

transporter activity

ATP binding

plasma membrane

transport

visual perception

integral to membrane

ATPase activity

response to drug

ATPase activity, coupled to transmembrane movement of substances

response to stimulus

ABC transporters

219507_at RSRC1 arginine/serine-rich coiled-coil 1 3 159310585 NM_016625 3q25.32 Hs.591283 5

alternative nuclear mRNA splicing, via spliceosome

protein binding

nucleus

protein amino acid phosphorylation

nucleocytoplasmic transport

RNA splicing

nuclear speck

response to antibiotic

 
1556641_at SLC7A14 solute carrier family 7 (cationic amino acid transporter, y+ system), member 14 3 -171660035 AK094547 3q26.2 Hs.596660 4

transport

amino acid transport

amino acid transmembrane transporter activity

membrane

integral to membrane

 
227696_at EXOSC6 exosome component 6 16 -68841634 AI701408 16q22.1 Hs.660633 Hs.719211 9

3'-5'-exoribonuclease activity

exosome (RNase complex)

RNA binding

exonuclease activity

nucleus

nucleolus

cytoplasm

rRNA processing

RNA processing

hydrolase activity

RNA degradation

203586_s_at ARL4D ADP-ribosylation factor-like 4D 17 38831878 NM_001661 17q12-q21 Hs.183153 Hs.709866 13

nucleotide binding

GTPase activity

GTP binding

intracellular

nucleus

nucleolus

small GTPase mediated signal transduction

protein secretion

 
229707_at ZNF606 zinc finger protein 606 19 -63180252 AI817719 19q13.4 Hs.654967 6

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
229659_s_at PIGR polymeric immunoglobulin receptor 1 -205168491 BE501712 1q31-q41 Hs.497589 56

protein binding

extracellular region

plasma membrane

integral to plasma membrane

 
213727_x_at MPPE1 metallophosphoesterase 1 18 -11873471 AI743654 18p11.21 Hs.712666 8

membrane

integral to membrane

hydrolase activity

metal ion binding

 
244264_at KLRG2 killer cell lectin-like receptor subfamily G, member 2 7 -138788627 AW197495 7q34 Hs.17572 2

binding

sugar binding

membrane

integral to membrane

 
236087_at 0.306 6.534 2.509 2.390e-02 0.509 -3.292 ABLIM2 actin binding LIM protein family, member 2 4 -8059647, -8017936 AI912773 4p16.1 Hs.233404 9

actin binding

cytoplasm

cytoskeleton organization

zinc ion binding

actin cytoskeleton

myofibril

positive regulation of transcription from RNA polymerase II promoter

metal ion binding

Axon guidance

235977_at LONRF2 LON peptidase N-terminal domain and ring finger 2 2 -100256184 BF433341 2q11.2 Hs.21380 4

ATP-dependent peptidase activity

protein binding

proteolysis

zinc ion binding

metal ion binding

 
1553207_at ARL10 ADP-ribosylation factor-like 10 5 175725107 NM_173664 5q35.2 Hs.424552 3

nucleotide binding

GTP binding

 
224663_s_at CFL2 cofilin 2 (muscle) 14 -34249338, -34249338, -34249338 BF576053 14q12 Hs.180141 20

actin binding

protein binding

intracellular

nucleus

cytoplasm

cytoskeleton

nuclear matrix

Axon guidance

Fc gamma R-mediated phagocytosis

Regulation of actin cytoskeleton

212752_at CLASP1 cytoplasmic linker associated protein 1 2 -121811823 AA176798 2q14.2-q14.3 Hs.469840 Hs.708183 21

condensed chromosome kinetochore

microtubule bundle formation

protein binding

cytoplasm

Golgi apparatus

kinetochore microtubule

cytoskeleton

cytoplasmic microtubule

cell cortex

negative regulation of microtubule depolymerization

negative regulation of microtubule depolymerization

cell cycle

mitosis

establishment or maintenance of cell polarity

exit from mitosis

cortical microtubule cytoskeleton

centrosomal corona

kinetochore binding

microtubule plus-end binding

cell division

 
1567064_at OR1Q1 olfactory receptor, family 1, subfamily Q, member 1 9 124416837 X89667 9q33.2 Hs.684864 3

receptor activity

olfactory receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

sensory perception of smell

integral to membrane

response to stimulus

Olfactory transduction

202754_at R3HDM1 R3H domain containing 1 2 136005552 NM_015361 2q21.3 Hs.412462 8

nucleic acid binding

 
207628_s_at WBSCR22 Williams Beuren syndrome chromosome region 22 7 72735833 NM_017528   Hs.647063 9

cellular_component

nucleus

metabolic process

methyltransferase activity

transferase activity

Androgen and estrogen metabolism

Histidine metabolism

Tyrosine metabolism

Aminophosphonate metabolism

Selenoamino acid metabolism

1561423_at LOC642924 hypothetical protein LOC642924 8   BC037909 8q22.1 Hs.434882 1    
225605_at TP53I13 tumor protein p53 inducible protein 13 17 24919864 AL540867 17q11.2 Hs.514050 4

cytoplasm

plasma membrane

integral to membrane

 
202213_s_at CUL4B cullin 4B X -119542473, -119542473 AI650819 Xq23 Hs.102914 28

molecular_function

protein binding

cellular_component

DNA repair

ubiquitin-dependent protein catabolic process

response to DNA damage stimulus

cell cycle

cullin-RING ubiquitin ligase complex

ubiquitin protein ligase binding

Nucleotide excision repair

Ubiquitin mediated proteolysis

230081_at PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 5 -41342804 AI694325 5p13.1 Hs.145404  

phospholipase C activity

signal transducer activity

intracellular signaling cascade

lipid catabolic process

hydrolase activity

 
211376_s_at 0.184 6.571 2.224 4.173e-02 0.574 -3.755 NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 10 -123706592 BC005212 10q26.13 Hs.258798 8    
226264_at SUSD1 sushi domain containing 1 9 -113842881 AL137432 9q31.3-q33.1 Hs.494827 8

calcium ion binding

membrane

integral to membrane

 
218856_at 0.692 5.906 4.189 7.675e-04 0.211 -0.377 TNFRSF21 tumor necrosis factor receptor superfamily, member 21 6 -47307226 NM_016629 6p21.1-p12.2 Hs.443577 15

receptor activity

protein binding

apoptosis

signal transduction

membrane

integral to membrane

Cytokine-cytokine receptor interaction

209198_s_at SYT11 synaptotagmin XI 1 154095913 BC004291 1q21.2 Hs.32984 14

transporter activity

calcium ion binding

protein binding

calcium-dependent phospholipid binding

integral to plasma membrane

transport

synaptic vesicle

membrane

cell junction

cytoplasmic vesicle

synapse

 
210544_s_at 0.795 6.810 4.706 2.713e-04 0.175 0.492 ALDH3A2 aldehyde dehydrogenase 3 family, member A2 17 19492655, 19492655 BC002430 17p11.2 Hs.499886 27

3-chloroallyl aldehyde dehydrogenase activity

aldehyde dehydrogenase (NAD) activity

aldehyde dehydrogenase [NAD(P)+] activity

mitochondrial inner membrane

endoplasmic reticulum

cellular aldehyde metabolic process

lipid metabolic process

central nervous system development

peripheral nervous system development

epidermis development

membrane

integral to membrane

oxidoreductase activity

oxidation reduction

Glycolysis / Gluconeogenesis

Ascorbate and aldarate metabolism

Fatty acid metabolism

Valine, leucine and isoleucine degradation

Lysine degradation

Arginine and proline metabolism

Histidine metabolism

Tryptophan metabolism

beta-Alanine metabolism

Glycerolipid metabolism

Pyruvate metabolism

Propanoate metabolism

3-Chloroacrylic acid degradation

Butanoate metabolism

Limonene and pinene degradation

Metabolic pathways

209727_at GM2A GM2 ganglioside activator 5 150612805 M76477 5q31.3-q33.1 Hs.483873 32

lipid transporter activity

cytoplasm

mitochondrion

lysosome

hydrogen:potassium-exchanging ATPase complex

lipid metabolic process

ganglioside catabolic process

lipid transport

learning or memory

oligosaccharide catabolic process

internal side of plasma membrane

phospholipase activator activity

glycolipid catabolic process

lipid storage

sphingolipid catabolic process

sphingolipid activator protein activity

beta-N-acetylgalactosaminidase activity

apical cortex

neurological system process

neuromuscular process controlling balance

positive regulation of hydrolase activity

Lysosome

226934_at CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 12 67919583 AU149663 12q15 Hs.369606 19

nucleotide binding

RNA binding

protein binding

nucleus

mRNA cleavage factor complex

mRNA processing

ribonucleoprotein complex

paraspeckles

 
1558747_at SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 18 2645885 AA336502 18p11.32 Hs.8118 6

protein binding

ATP binding

chromosome

chromosome organization

 
222665_at 0.286 7.251 2.576 2.090e-02 0.497 -3.179 FAM82B family with sequence similarity 82, member B 8 -87553693 AK000672 8q21.3 Hs.145386 5

binding

cytoplasm

microtubule

 
202399_s_at 0.462 8.150 3.615 2.497e-03 0.287 -1.376 AP3S2 adaptor-related protein complex 3, sigma 2 subunit 15 -88174834 NM_005829 15q26.1 Hs.632161 14

protein binding

Golgi apparatus

intracellular protein transport

protein transporter activity

membrane

vesicle-mediated transport

membrane coat

cytoplasmic vesicle

Lysosome

205164_at GCAT glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A ligase) 22 36533900 NM_014291 22q13.1 Hs.54609 6

mitochondrion

mitochondrial inner membrane

cellular amino acid metabolic process

acyltransferase activity

glycine C-acetyltransferase activity

biosynthetic process

transferase activity, transferring nitrogenous groups

pyridoxal phosphate binding

Glycine, serine and threonine metabolism

221211_s_at C21orf7 chromosome 21 open reading frame 7 21 29374743 NM_020152 21q22.3 Hs.222802 13

protein binding

nucleus

cytosol

 
226727_at CISD3 CDGSH iron sulfur domain 3 17 34140035 BG171264 17q12 Hs.713595 4

iron ion binding

mitochondrion

metal ion binding

2 iron, 2 sulfur cluster binding

 
218909_at RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 1 211291210 NM_012424 1q41 Hs.591416 10

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

early endosome

protein amino acid phosphorylation

signal transduction

membrane

transferase activity

phosphoinositide binding

 
201927_s_at PKP4 plakophilin 4 2 159021721 BG292559 2q23-q31 Hs.407580 27

protein binding

cell adhesion

desmosome

 
212858_at PAQR4 progestin and adipoQ receptor family member IV 16 2959342 AL520675 16p13.3 Hs.351474 5

receptor activity

membrane

integral to membrane

 
209999_x_at SOCS1 suppressor of cytokine signaling 1 16 -11255774 AI056051 16p13.13 Hs.50640 122

regulation of protein amino acid phosphorylation

protein kinase inhibitor activity

insulin-like growth factor receptor binding

protein binding

cytoplasm

intracellular signaling cascade

cytokine-mediated signaling pathway

protein kinase binding

modification-dependent protein catabolic process

regulation of growth

negative regulation of tyrosine phosphorylation of Stat3 protein

fat cell differentiation

negative regulation of JAK-STAT cascade

negative regulation of JAK-STAT cascade

negative regulation of insulin receptor signaling pathway

Ubiquitin mediated proteolysis

Jak-STAT signaling pathway

Insulin signaling pathway

Type II diabetes mellitus

220794_at GREM2 gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis) 1 -238719495 NM_022469 1q43 Hs.98206 9

cytokine activity

extracellular region

extracellular region

extracellular space

BMP signaling pathway

 
204186_s_at PPID peptidylprolyl isomerase D 4 -159849728 AI014573 4q31.3 Hs.581725 25

peptidyl-prolyl cis-trans isomerase activity

cytoplasm

protein folding

cyclosporin A binding

isomerase activity

heat shock protein binding

Calcium signaling pathway

Parkinson's disease

Huntington's disease

200976_s_at 0.348 9.179 2.494 2.460e-02 0.513 -3.316 TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 7 27746262 NM_006024 7p15 Hs.34576 21

intracellular

apoptosis

anti-apoptosis

zinc ion binding

identical protein binding

 
224385_s_at MOV10L1 Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) 22 48870561, 48870811, 48927610 AF285604 22q13.33 Hs.62880 7

nucleotide binding

magnesium ion binding

RNA binding

ATP-dependent RNA helicase activity

helicase activity

ATP binding

intracellular

multicellular organismal development

germ cell development

spermatogenesis

muscle organ development

cell proliferation

hydrolase activity

negative regulation of cell cycle

 
226735_at TAPT1 transmembrane anterior posterior transformation 1 4 -15771225 AI239899 4p15.32 Hs.479223 5

receptor activity

multicellular organismal development

membrane

integral to membrane

 
203459_s_at VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 20 2769372, 2792592 NM_022575 20p13-p12 Hs.269577 6

cytoplasm

lysosome

endosome

intracellular protein transport

membrane

 
227825_at NAIF1 nuclear apoptosis inducing factor 1 9 -129863332 BE293321 9q34.11 Hs.373606 8

molecular_function

nucleus

apoptosis

induction of apoptosis

 
210602_s_at CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 5 31229552 BC000019 5p15.1-p14 Hs.171054 14

calcium ion binding

protein binding

nucleus

cytoplasm

plasma membrane

cell adhesion

homophilic cell adhesion

female gonad development

integral to membrane

 
228017_s_at NKAIN4 Na+/K+ transporting ATPase interacting 4 20 -61342581 BF593263 20q13.33 Hs.46627 7

plasma membrane

integral to membrane

 
220092_s_at ANTXR1 anthrax toxin receptor 1 2 69093779, 69093779, 69093779 NM_018153 2p13.1 Hs.165859 24

transmembrane receptor activity

collagen binding

membrane

integral to membrane

lamellipodium membrane

filopodium membrane

actin cytoskeleton reorganization

substrate adhesion-dependent cell spreading

metal ion binding

actin filament binding

 
217884_at NAT10 N-acetyltransferase 10 (GCN5-related) 11 34083686 NM_024662 11p13 Hs.577281 18

nucleotide binding

molecular_function

protein binding

ATP binding

nucleus

nucleolus

N-acetyltransferase activity

metabolic process

acyltransferase activity

transferase activity

 
223925_s_at LUZP6 leucine zipper protein 6 7 -135262042 AF130088 7q33 Hs.654894 2    
201932_at 0.213 7.023 2.288 3.685e-02 0.561 -3.652 LRRC41 leucine rich repeat containing 41 1 -46516658 NM_006369 1p34.1 Hs.144941 12

modification-dependent protein catabolic process

 
227956_at ITPRIPL2 inositol 1,4,5-triphosphate receptor interacting protein-like 2 16 19032754 AI458417 16p12.3 Hs.530899 Hs.648523 3

membrane

integral to membrane

 
1552293_at TMEM196 transmembrane protein 196 7 -19725463 NM_152774 7p21.1 Hs.487670 1

membrane

integral to membrane

 
238448_at 0.316 2.945 2.894 1.101e-02 0.424 -2.637 MRPL19 mitochondrial ribosomal protein L19 2 75727416 BE544070 2q11.1-q11.2 Hs.44024 11

structural constituent of ribosome

intracellular

nucleus

mitochondrion

ribosome

translation

nuclear membrane

 
224777_s_at PAFAH1B2 platelet-activating factor acetylhydrolase, isoform Ib, subunit 2 (30kDa) 11 116520249 BG386322 11q23 Hs.718419 15

1-alkyl-2-acetylglycerophosphocholine esterase activity

protein binding

cytoplasm

spermatogenesis

lipid catabolic process

hydrolase activity, acting on ester bonds

Ether lipid metabolism

Metabolic pathways

208670_s_at EID1 EP300 interacting inhibitor of differentiation 1 15 46957581 AF274951 15q21.1-q21.2 Hs.255973 Hs.714048 12

negative regulation of transcription from RNA polymerase II promoter

transcription corepressor activity

protein binding

cellular_component

nucleus

cytoplasm

cell cycle

specific transcriptional repressor activity

cell differentiation

histone acetyltransferase regulator activity

histone acetyltransferase binding

regulation of transcription

 
207216_at TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 9 -116704944 NM_001244 9q33 Hs.654445 19

cytokine activity

tumor necrosis factor receptor binding

extracellular space

integral to plasma membrane

induction of apoptosis

immune response

signal transduction

cell-cell signaling

cell proliferation

membrane

Cytokine-cytokine receptor interaction

229547_s_at WNK2 WNK lysine deficient protein kinase 2 9 94987032 AI832477 9q22.3 Hs.654856 13

nucleotide binding

protein serine/threonine kinase activity

protein binding

ATP binding

protein amino acid phosphorylation

protein kinase cascade

transferase activity

 
1563252_at ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 12 54760158, 54760158 U88360 12q13 Hs.118681 136

nucleotide binding

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor activity

ATP binding

extracellular region

extracellular space

plasma membrane

integral to plasma membrane

protein amino acid phosphorylation

negative regulation of cell adhesion

transmembrane receptor protein tyrosine kinase signaling pathway

heart development

negative regulation of signal transduction

Schwann cell differentiation

positive regulation of phosphoinositide 3-kinase cascade

basolateral plasma membrane

apical plasma membrane

lateral plasma membrane

transferase activity

growth factor binding

growth factor binding

cranial nerve development

protein tyrosine kinase activator activity

wound healing

regulation of cell proliferation

protein homodimerization activity

receptor complex

negative regulation of neuron apoptosis

protein heterodimerization activity

negative regulation of secretion

ErbB signaling pathway

Calcium signaling pathway

Endocytosis

217565_at GRIA3 glutamate receptor, ionotrophic, AMPA 3 X 122145776 BF110551 Xq25-q26 Hs.377070 34

receptor activity

ionotropic glutamate receptor activity

ion channel activity

extracellular-glutamate-gated ion channel activity

plasma membrane

ion transport

glutamate signaling pathway

integral to membrane

cell junction

synapse

postsynaptic membrane

Neuroactive ligand-receptor interaction

Long-term depression

223436_s_at 0.614 8.773 2.195 4.412e-02 0.579 -3.801 TRPT1 tRNA phosphotransferase 1 11 -63747847, -63747847 BC005133 11q13.1 Hs.326586 6

tRNA 2'-phosphotransferase activity

tRNA splicing, via endonucleolytic cleavage and ligation

transferase activity, transferring phosphorus-containing groups

 
212204_at TMEM87A transmembrane protein 87A 15 -40337427, -40290017 AL049944 15q15.1 Hs.511138 Hs.719196 6

membrane

integral to membrane

 
217814_at CCDC47 coiled-coil domain containing 47 17 -59176341 NM_020198 17q23.3 Hs.202011 9

protein binding

cellular_component

biological_process

membrane

integral to membrane

 
218042_at COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 4 84175262 NM_016129 4q21.22 Hs.190384 22

protein binding

nucleus

cytoplasm

signalosome

 
218582_at 0.540 7.441 2.703 1.620e-02 0.461 -2.964 MARCH5 membrane-associated ring finger (C3HC4) 5 10 94040899 NM_017824 10q23.32-q23.33 Hs.573490 8

mitochondrion

mitochondrial outer membrane

zinc ion binding

membrane

integral to membrane

ligase activity

modification-dependent protein catabolic process

metal ion binding

 
235551_at WDR4 WD repeat domain 4 21 -43142404, -43136272 AA555280 21q22.3 Hs.248815 10

protein binding

nucleus

nucleoplasm

cytoplasm

tRNA modification

tRNA (guanine-N7-)-methyltransferase activity

 
1557217_a_at FANCB Fanconi anemia, complementation group B X -14771449 BC043596 Xp22.2 Hs.554740 16

nucleus

DNA repair

response to DNA damage stimulus

 
233905_at SPAG4L sperm associated antigen 4-like 20 -31035241 AL139826 20q11.21 Hs.375186 8

molecular_function

cellular_component

spermatogenesis

 
223144_s_at AKIRIN2 akirin 2 6 -88441298 BC000764 6q15 Hs.485915 10

protein binding

nucleus

embryonic development

transcriptional repressor complex

response to lipopolysaccharide

positive regulation of interleukin-6 production

innate immune response

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

 
214165_s_at HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2 -128739523 BF512553 2q21 Hs.512841 6

angiogenesis

placenta development

integral to plasma membrane

sulfotransferase activity

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

membrane

transferase activity

lung alveolus development

Heparan sulfate biosynthesis

220130_x_at LTB4R2 leukotriene B4 receptor 2 14 23848000 NM_019839 14q11.2-q12 Hs.642693 Hs.657595 Hs.711130 22

leukotriene B4 receptor activity

receptor activity

membrane fraction

plasma membrane

integral to plasma membrane

chemotaxis

signal transduction

G-protein coupled receptor protein signaling pathway

negative regulation of adenylate cyclase activity

keratinocyte migration

Calcium signaling pathway

Neuroactive ligand-receptor interaction

216696_s_at PRODH2 proline dehydrogenase (oxidase) 2 19 -40982731 U95090 19q13.1 Hs.515366 2

proline dehydrogenase activity

mitochondrial inner membrane

glutamate biosynthetic process

proline catabolic process

oxidoreductase activity

oxidation reduction

Arginine and proline metabolism

Metabolic pathways

221276_s_at SYNC syncoilin, intermediate filament protein 1 -32918093 NM_030786 1p34.3-p33 Hs.712631 6

structural molecule activity

protein binding

cytoplasm

cytosol

intermediate filament

Z disc

sarcolemma

intermediate filament-based process

synapse

perinuclear region of cytoplasm

 
208933_s_at 0.453 5.692 3.953 1.244e-03 0.236 -0.785 LGALS8 lectin, galactoside-binding, soluble, 8 1 234748187, 234753361, 234753699 AI659005 1q42-q43 Hs.4082 Hs.708114 29

sugar binding

extracellular space

cytoplasm

 
220674_at CD22 CD22 molecule 19 40511918 NM_024916 19q13.1 Hs.579691 46

protein binding

sugar binding

plasma membrane

cell adhesion

integral to membrane

Cell adhesion molecules (CAMs)

Hematopoietic cell lineage

B cell receptor signaling pathway

225540_at 0.390 4.931 2.336 3.357e-02 0.552 -3.575 MAP2 microtubule-associated protein 2 2 209997015, 210152647 BF342661 2q34-q35 Hs.368281 58

structural molecule activity

calmodulin binding

cytoplasm

cytoskeleton

microtubule

microtubule associated complex

negative regulation of microtubule depolymerization

 
202271_at FBXO28 F-box protein 28 1 222368413 AB007952 1q42.11 Hs.64691 Hs.713992 10

modification-dependent protein catabolic process

 
233048_at FAM35A family with sequence similarity 35, member A 10 88844932 AK025471 10q23.2 Hs.500419 6    
207608_x_at -0.402 6.600 -2.352 3.252e-02 0.548 -3.549 CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 15 72828236 NM_000761 15q24.1 Hs.1361 233

endoplasmic reticulum

endoplasmic reticulum membrane

microsome

cellular aromatic compound metabolic process

porphyrin metabolic process

electron carrier activity

toxin metabolic process

post-embryonic development

regulation of gene expression

membrane

drug metabolic process

dibenzo-p-dioxin metabolic process

oxygen binding

heme binding

lung development

demethylase activity

cellular respiration

metal ion binding

hydrogen peroxide biosynthetic process

oxidation reduction

aromatase activity

Caffeine metabolism

Tryptophan metabolism

Linoleic acid metabolism

Retinol metabolism

Metabolism of xenobiotics by cytochrome P450

Drug metabolism - cytochrome P450

Metabolic pathways

205747_at CBLN1 cerebellin 1 precursor 16 -47869711 NM_004352 16q12.1 Hs.458423 8

protein binding

extracellular region

synaptic transmission

nervous system development

membrane

cell junction

protein homodimerization activity

synapse

 
215011_at SNHG3 small nucleolar RNA host gene 3 (non-protein coding) 1 28705082 AJ006835 1p36.1 Hs.469723 5    
1567068_at OR4D1 olfactory receptor, family 4, subfamily D, member 1 17 53587513 X89670 17q23.2 Hs.531188 3

receptor activity

olfactory receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

sensory perception of smell

integral to membrane

response to stimulus

Olfactory transduction

243301_at COL22A1 collagen, type XXII, alpha 1 8 -139669659 AW241910 8q24.23-q24.3 Hs.117169 2    
220395_at DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 15 76343541, 76344043, 76345614 NM_018602 15q25.1 Hs.513053 5

protein folding

zinc ion binding

membrane

heat shock protein binding

metal ion binding

unfolded protein binding

 
218079_s_at GGNBP2 gametogenetin binding protein 2 17 31974916 NM_024835 17q12 Hs.514116 4

multicellular organismal development

spermatogenesis

cell differentiation

cytoplasmic vesicle

 
221634_at RPL23AP7 ribosomal protein L23a pseudogene 7 2 -114095774, -114085285 BC000596 2q14 Hs.541177 Hs.595056 6    
209762_x_at SP110 SP110 nuclear body protein 2 -230749432, -230741889 AF280094 2q37.1 Hs.145150 20

DNA binding

hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity

protein binding

nucleus

zinc ion binding

interspecies interaction between organisms

regulation of transcription

metal ion binding

 
AFFX-HUMISGF3A/M97935_MA_at -0.196 5.781 -2.162 4.692e-02 0.583 -3.852 STAT1 signal transducer and activator of transcription 1, 91kDa 2 -191548507, -191542006 AFFX-HUMISGF3A/M97935_MA 2q32.2 Hs.642990 Hs.715518 323

transcription factor activity

signal transducer activity

hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity

calcium ion binding

protein binding

nucleus

nucleolus

cytoplasm

regulation of transcription, DNA-dependent

transcription from RNA polymerase II promoter

activation of caspase activity

signal transduction

I-kappaB kinase/NF-kappaB cascade

tyrosine phosphorylation of STAT protein

response to virus

interspecies interaction between organisms

Chemokine signaling pathway

Toll-like receptor signaling pathway

Jak-STAT signaling pathway

Pathways in cancer

Pancreatic cancer

212721_at SFRS12 splicing factor, arginine/serine-rich 12 5 65475840, 65476418 AI810380 5q12.3 Hs.519347 12

nucleotide binding

nucleic acid binding

protein binding

nucleus

spliceosomal complex

mRNA processing

RNA splicing

 
205526_s_at KATNA1 katanin p60 (ATPase-containing) subunit A 1 6 -149957864 NM_007044 6q25.1 Hs.450175 12

nucleotide binding

spindle pole

ATP binding

cytoplasm

centrosome

microtubule

cell cycle

mitosis

microtubule binding

microtubule-severing ATPase activity

hydrolase activity

nucleoside-triphosphatase activity

protein heterodimerization activity

cell division

interphase of mitotic cell cycle

 
231784_s_at DCAF13 DDB1 and CUL4 associated factor 13 8 104496117 AK001874 8q22.3 Hs.532265 4

nucleus

nucleolus

rRNA processing

ribonucleoprotein complex

 
222318_at ZNF324B zinc finger protein 324B 19 63654782 AI744673 19q13.43 Hs.186970 3

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
236834_at SCFD2 sec1 family domain containing 2 4 -53433907 AI025103 4q12 Hs.302287 3

vesicle docking during exocytosis

protein transport

vesicle-mediated transport

 
213115_at ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae) X 107221589 AL031177 Xq22.1-q22.3 Hs.8763 8

cytoplasm

microtubule associated complex

proteolysis

protein targeting to vacuole

autophagy

microtubule binding

peptidase activity

cysteine-type peptidase activity

protein transport

modification-dependent protein catabolic process

Regulation of autophagy

212735_at KIAA0226 KIAA0226 3 -198882710, -198882655 BF448041 3q29 Hs.478868 6    
227088_at PDE5A phosphodiesterase 5A, cGMP-specific 4 -120634997, -120634997, -120634997 BF221547 4q25-q27 Hs.587281 Hs.647971 43

nucleotide binding

magnesium ion binding

cellular_component

signal transduction

zinc ion binding

cyclic nucleotide metabolic process

hydrolase activity

cGMP binding

3',5'-cyclic-GMP phosphodiesterase activity

Purine metabolism

215463_at -0.353 4.096 -2.380 3.084e-02 0.542 -3.504 OR7E24 olfactory receptor, family 7, subfamily E, member 24 19 9222719 BF062364 19p13.2 Hs.129832 5

receptor activity

olfactory receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

sensory perception of smell

integral to membrane

response to stimulus

Olfactory transduction

204450_x_at APOA1 apolipoprotein A-I 11 -116211678, 13497 NM_000039 11q23-q24 Hs.633003 424

beta-amyloid binding

negative regulation of cytokine secretion during immune response

phospholipid binding

extracellular region

extracellular region

endoplasmic reticulum lumen

lipid metabolic process

phosphatidylcholine biosynthetic process

lipid transport

G-protein coupled receptor protein signaling pathway

steroid metabolic process

cholesterol metabolic process

positive regulation of cholesterol esterification

negative regulation of very-low-density lipoprotein particle remodeling

cholesterol binding

cholesterol transporter activity

cholesterol transporter activity

enzyme binding

endocytic vesicle

cytoplasmic vesicle

Cdc42 protein signal transduction

cholesterol efflux

phospholipid efflux

apolipoprotein A-I receptor binding

very-low-density lipoprotein particle

spherical high-density lipoprotein particle

high-density lipoprotein particle assembly

high-density lipoprotein particle clearance

lipoprotein metabolic process

cholesterol homeostasis

identical protein binding

reverse cholesterol transport

negative regulation of interleukin-1 beta secretion

protein stabilization

positive regulation of hydrolase activity

phosphatidylcholine-sterol O-acyltransferase activator activity

cholesterol import

high-density lipoprotein receptor binding

PPAR signaling pathway

235472_at FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase) 8 -33347885 AI147738 8p12 Hs.458713 5

Golgi membrane

Golgi apparatus

protein folding

protein amino acid glycosylation

protein targeting

nervous system development

fertilization

embryonic development

membrane

integral to membrane

transferase activity, transferring glycosyl groups

hemopoiesis

wound healing

L-fucose catabolic process

alpha(1,3)-fucosyltransferase activity

 
227733_at TMEM63C transmembrane protein 63C 14 76717854 AA928939 14q24.3 Hs.22452 3

membrane

integral to membrane

 
219816_s_at RBM23 RNA binding motif protein 23 14 -22439693 NM_018107 14q11.2 Hs.4997 11

nucleotide binding

RNA binding

nucleus

nucleolus

mRNA processing

 
217066_s_at DMPK dystrophia myotonica-protein kinase 19 -50964815, -50964815 M87313 19q13.3 Hs.631596 91

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

protein binding

ATP binding

protein modification process

protein amino acid phosphorylation

regulation of heart contraction

transferase activity

 
1562443_at RLBP1L2 retinaldehyde binding protein 1-like 2 6 123359280 AK095527 6q22.31 Hs.486361 2

transporter activity

intracellular

transport

 
226106_at RNF141 ring finger protein 141 11 -10489800 AI307808 11p15.4 Hs.44685 7

DNA binding

protein binding

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
222621_at DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 10 -22085482 BF591419 10p12.31 Hs.499000 8

ATPase activator activity

DNA binding

nucleus

endoplasmic reticulum

microsome

regulation of translation

protein folding

membrane

integral to membrane

heat shock protein binding

negative regulation of proteolysis

regulation of protein secretion

unfolded protein binding

chaperone binding

 
1555981_at C17orf65 chromosome 17 open reading frame 65 17 -39608877 AK055685 17q21.31 Hs.656564 2    
224299_x_at FTCD formiminotransferase cyclodeaminase 21 -46381121, -46380603 AF289023 21q22.3 Hs.415846 11

folic acid binding

cytoplasm

Golgi apparatus

histidine metabolic process

folic acid and derivative metabolic process

transferase activity

lyase activity

glutamate formimidoyltransferase activity

formimidoyltetrahydrofolate cyclodeaminase activity

cellular metabolic process

Histidine metabolism

One carbon pool by folate

Metabolic pathways

206570_s_at PSG11 pregnancy specific beta-1-glycoprotein 11 19 -48203648 NM_002785 19q13.2 Hs.646353 6

extracellular region

female pregnancy

 
226489_at TMCC3 transmembrane and coiled-coil domain family 3 12 -93485030 BG177562 12q22 Hs.370410 5

membrane

integral to membrane

 
1557123_a_at -0.206 4.982 -2.146 4.842e-02 0.589 -3.877 CHADL chondroadherin-like 22 -39955459 BC040188 22q13.2 Hs.344488 Hs.714982 2

protein binding

extracellular region

proteinaceous extracellular matrix

 
229229_at AGXT2 alanine-glyoxylate aminotransferase 2 5 -35033962 AJ292204 5p13 Hs.34494 7

mitochondrion

alanine-glyoxylate transaminase activity

transferase activity

pyridoxal phosphate binding

(R)-3-amino-2-methylpropionate-pyruvate transaminase activity

Alanine, aspartate and glutamate metabolism

222429_at 0.291 5.674 2.728 1.542e-02 0.458 -2.923 DBNL drebrin-like 7 44050763 AF077353 7p13 Hs.436500 26

ruffle

intracellular

cytoplasm

cytoskeleton

cell cortex

endocytosis

immune response

activation of JUN kinase activity

enzyme activator activity

Rac protein signal transduction

lamellipodium

identical protein binding

actin filament binding

 
220003_at -0.191 5.856 -2.430 2.795e-02 0.529 -3.423 LRRC36 leucine rich repeat containing 36 16 65918247, 65938758 NM_018296 16q22.1 Hs.125139 3

protein binding

 
231195_at KLRG2 killer cell lectin-like receptor subfamily G, member 2 7 -138788627 AI492376 7q34 Hs.17572 2

binding

sugar binding

membrane

integral to membrane

 
202920_at ANK2 ankyrin 2, neuronal 4 113958687, 114190233 BF726212 4q25-q27 Hs.620557 39

protein binding

cytoplasm

cytoskeleton

plasma membrane

signal transduction

basolateral plasma membrane

apical plasma membrane

M band

 
235397_at NCRNA00174 non-protein coding RNA 174 7 -65478466 AA020789 7q11.21 Hs.50755 3    
241832_at FAM98A family with sequence similarity 98, member A 2 -33662232 AI864271 2p22.3 Hs.468140 2    
210423_s_at SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 2 218954995 L32185 2q35 Hs.591607 106

transporter activity

iron ion binding

vacuole

plasma membrane

integral to plasma membrane

ion transport

iron ion transport

cellular cadmium ion homeostasis

cellular iron ion homeostasis

response to bacterium

phagocytic vesicle membrane

protein homodimerization activity

transition metal ion transmembrane transporter activity

metal ion:hydrogen antiporter activity

cadmium ion transmembrane transport

Lysosome

203600_s_at C4orf8 chromosome 4 open reading frame 8 4 2596956 NM_003704 4p16.3 Hs.652364 4    
1559399_s_at 0.539 4.963 2.368 3.154e-02 0.544 -3.523 ZCCHC10 zinc finger, CCHC domain containing 10 5 -132360575 BC015986 5q31.1 Hs.29700 5

nucleic acid binding

zinc ion binding

metal ion binding

 
242242_at USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene) 17 4972410 AA291110 17p13 Hs.448851 21

nucleic acid binding

cysteine-type endopeptidase activity

ubiquitin thiolesterase activity

Rab GTPase activator activity

protein binding

intracellular

lysosome

protein modification process

ubiquitin-dependent protein catabolic process

peptidase activity

regulation of Rab GTPase activity

 
228504_at SCN7A sodium channel, voltage-gated, type VII, alpha 2 -166969784 AI828648 2q21-q23 Hs.695947 11

voltage-gated sodium channel complex

voltage-gated ion channel activity

voltage-gated sodium channel activity

ion transport

sodium ion transport

muscle contraction

membrane

integral to membrane

sodium ion binding

 
221692_s_at MRPL34 mitochondrial ribosomal protein L34 19 17277476 AB049652 19p13.1 Hs.515242 6

structural constituent of ribosome

intracellular

mitochondrion

mitochondrial large ribosomal subunit

ribosome

translation

translation regulator activity

 
203604_at ZNF516 zinc finger protein 516 18 -72200606 N38750 18q23 Hs.709890 4

DNA binding

intracellular

nucleus

cytoplasm

zinc ion binding

regulation of transcription

metal ion binding

 
226901_at 0.533 6.607 3.275 5.035e-03 0.345 -1.973 C17orf58 chromosome 17 open reading frame 58 17 -63417678 AI214996 17q24.2 Hs.90790 2

protein binding

 
1562736_at -0.303 3.089 -2.294 3.645e-02 0.559 -3.643 LHX9 LIM homeobox 9 1 196148257, 196153139 AJ277914 1q31-q32 Hs.442578 Hs.706475 6

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

sequence-specific DNA binding

metal ion binding

 
205001_s_at DDX3Y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked Y 13525412, 13526092 AF000985 Yq11 Hs.99120 19

nucleotide binding

DNA binding

RNA binding

helicase activity

ATP binding

nucleus

cytoplasm

plasma membrane

ATP-dependent helicase activity

hydrolase activity

RIG-I-like receptor signaling pathway

225816_at PHF17 PHD finger protein 17 4 129950228, 129950228 AW138134 4q26-q27 Hs.12420 14

histone acetyltransferase complex

protein binding

nucleus

cytoplasm

apoptosis

response to stress

zinc ion binding

negative regulation of cell growth

histone H3 acetylation

histone H4-K5 acetylation

histone H4-K8 acetylation

histone H4-K12 acetylation

histone H4-K16 acetylation

regulation of transcription

metal ion binding

 
1556771_a_at -0.272 5.092 -2.634 1.861e-02 0.486 -3.081 LOC415056 hypothetical LOC415056 9 34558009 BC038740 9p13 Hs.662209 1    
222243_s_at TOB2 transducer of ERBB2, 2 22 -40159437 AB051450 22q13.2-q13.31 Hs.719120 9

nucleus

cytoplasm

female gamete generation

negative regulation of cell proliferation

regulation of gene expression

vitamin D receptor binding

negative regulation of osteoclast differentiation

positive regulation of ossification

 
212935_at MCF2L MCF.2 cell line derived transforming sequence-like 13 112670757, 112681655 AB002360 13q34 Hs.170422 Hs.597691 15

guanyl-nucleotide exchange factor activity

Rho guanyl-nucleotide exchange factor activity

intracellular

cytoplasm

mitochondrion

plasma membrane

intracellular signaling cascade

regulation of Rho protein signal transduction

 
217840_at DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 5 -176871183 NM_016222 5q35.3 Hs.484288 14

nucleotide binding

RNA binding

helicase activity

protein binding

ATP binding

nucleus

spliceosomal complex

mRNA processing

apoptosis

multicellular organismal development

ATP-dependent helicase activity

zinc ion binding

RNA splicing

hydrolase activity

metal ion binding

 
1563426_a_at 0.334 4.127 2.241 4.035e-02 0.569 -3.727 LOC644613 hypothetical protein LOC644613 11   BC025792 11q13.1 Hs.604039 1    
215009_s_at SEC31A SEC31 homolog A (S. cerevisiae) 4 -83958837 U92014 4q21.22 Hs.370024 20

cytoplasm

endoplasmic reticulum

ER to Golgi vesicle-mediated transport

ER to Golgi vesicle-mediated transport

protein transport

membrane

membrane organization

vesicle-mediated transport

COPII vesicle coat

cytoplasmic vesicle

calcium-dependent protein binding

perinuclear region of cytoplasm

response to calcium ion

 
229369_at VSIG2 V-set and immunoglobulin domain containing 2 11 -124122579 AI201858 11q24 Hs.112377 6

membrane fraction

integral to plasma membrane

membrane

 
222969_at B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 2 168383427 AF117222 2q24.3 Hs.657258 13

Golgi membrane

Golgi apparatus

protein amino acid glycosylation

galactosyltransferase activity

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

oligosaccharide biosynthetic process

membrane

integral to membrane

transferase activity, transferring glycosyl groups

manganese ion binding

lipid glycosylation

Glycosphingolipid biosynthesis - lacto and neolacto series

Metabolic pathways

1555998_at ATP5H ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d 17 -70546549 BE646027 17q25 Hs.514465 13

mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

mitochondrion

ion transport

hydrogen ion transmembrane transporter activity

ATP synthesis coupled proton transport

proton transport

membrane

ATPase activity

Oxidative phosphorylation

Metabolic pathways

Alzheimer's disease

Parkinson's disease

Huntington's disease

214663_at DSTYK dual serine/threonine and tyrosine protein kinase 1 -203378254 AB007941 1q32.1 Hs.6874 9

nucleotide binding

protein serine/threonine kinase activity

protein tyrosine kinase activity

protein binding

ATP binding

cytoplasm

protein amino acid phosphorylation

transferase activity

 
206440_at LIN7A lin-7 homolog A (C. elegans) 12 -79715301 NM_004664 12q21 Hs.144333 17

protein binding

plasma membrane

tight junction

protein complex assembly

exocytosis

neurotransmitter secretion

protein transport

basolateral plasma membrane

synaptosome

cell junction

synapse

postsynaptic membrane

synaptic vesicle transport

 
223253_at EPDR1 ependymin related protein 1 (zebrafish) 7 37926687 BC000686 7p14.1 Hs.563491 7

calcium ion binding

extracellular region

lysosome

cell-matrix adhesion

 
244522_at SYVN1 synovial apoptosis inhibitor 1, synoviolin 11 -64651326 AA889078 11q13 Hs.715498 30

in utero embryonic development

protein binding

nucleus

nucleolus

endoplasmic reticulum

anti-apoptosis

response to stress

zinc ion binding

membrane

integral to membrane

ligase activity

acid-amino acid ligase activity

modification-dependent protein catabolic process

ER-associated protein catabolic process

metal ion binding

Ubiquitin mediated proteolysis

241601_at WIPF3 WAS/WASL interacting protein family, member 3 7 29840865 H58488 7p14.3 Hs.709280 5

actin binding

cytoplasm

multicellular organismal development

spermatogenesis

cell differentiation

 
244120_at -0.197 4.109 -2.351 3.258e-02 0.548 -3.550 LOC340178 hypothetical protein LOC340178 6   AW183280 6q27 Hs.343631 1    
235524_at GARNL1 GTPase activating Rap/RanGAP domain-like 1 14 -35077308 BF062295 14q13.2 Hs.113150 10

GTPase activator activity

intracellular

nucleus

cytoplasm

mitochondrion

regulation of small GTPase mediated signal transduction

 
200052_s_at 0.326 8.345 2.158 4.734e-02 0.585 -3.859 ILF2 interleukin enhancer binding factor 2, 45kDa 1 -151901137 NM_004515 1q21.3 Hs.75117 23

DNA binding

RNA polymerase II transcription factor activity

double-stranded RNA binding

protein binding

nucleus

nucleolus

regulation of transcription

positive regulation of transcription, DNA-dependent

 
1565559_at MAGIX MAGI family member, X-linked X 48906124, 48907213 AW418579 Xp11.23 Hs.193170 3

protein binding

 
1562365_at LOC286177 hypothetical protein LOC286177 8   BC036235 8q12.1 Hs.385655 1    
227312_at 0.489 5.488 2.233 4.100e-02 0.571 -3.741 SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 16 67778550 AI694536 16q22-q23 Hs.461117 22

actin binding

calcium ion binding

calmodulin binding

membrane fraction

cytoplasm

cytoskeleton

microtubule

dystrophin-associated glycoprotein complex

membrane

cell junction

cytoplasmic vesicle

synapse

 
232892_at 0.465 9.816 2.903 1.080e-02 0.421 -2.621 C20orf166 chromosome 20 open reading frame 166 20 60558104 AL449263 20q13.33 Hs.86507 5    
212861_at MFSD5 major facilitator superfamily domain containing 5 12 51932146 BF690150 12q13.13 Hs.654660 7

transport

membrane

integral to membrane

 
228544_s_at CSRP2BP CSRP2 binding protein 20 18066526, 18073742 AA780252 20p11.23 Hs.488051 8

protein binding

nucleus

cytoplasm

N-acetyltransferase activity

metabolic process

LIM domain binding

 
209472_at CCBL2 cysteine conjugate-beta lyase 2 1 -89174043 BC000819 1p22.2 Hs.481898 8

biosynthetic process

kynurenine-oxoglutarate transaminase activity

lyase activity

pyridoxal phosphate binding

cysteine-S-conjugate beta-lyase activity

 
204931_at TCF21 transcription factor 21 6 134251951, 134251952 NM_003206 6pter-qter Hs.78061 16

branching involved in ureteric bud morphogenesis

DNA binding

protein binding

nucleus

mesoderm development

sex differentiation

organ morphogenesis

transcription regulator activity

regulation of transcription

 
212211_at ANKRD17 ankyrin repeat domain 17 4 -74159365 AI986295 4q13.3 Hs.644997 Hs.719092 10

RNA binding

ATP binding

nucleus

cytoplasm

mismatch repair

mismatched DNA binding

interspecies interaction between organisms

 
238453_at 0.341 4.115 2.829 1.255e-02 0.429 -2.749 FGFBP3 fibroblast growth factor binding protein 3 10 -93656324 AI628573 10q23.32 Hs.466120 5

extracellular region

growth factor binding

 
1552913_at MAGEB18 melanoma antigen family B, 18 X 26066383 NM_173699 Xp21.3 Hs.350683 6

protein binding

 
1561951_at -0.239 3.062 -2.238 4.057e-02 0.570 -3.732 SLC5A12 solute carrier family 5 (sodium/glucose cotransporter), member 12 11 -26645141 BC029048 11p14.2 Hs.148907 3

transporter activity

plasma membrane

ion transport

sodium ion transport

symporter activity

integral to membrane

sodium ion binding

 
232391_at ZNF461 zinc finger protein 461 19 -41820122 AB021641 19q13.12 Hs.590972 5

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
210202_s_at BIN1 bridging integrator 1 2 -127522077, -127522076 U87558 2q14 Hs.193163 69

protein binding

nucleus

cytoplasm

multicellular organismal development

cell proliferation

actin cytoskeleton

regulation of endocytosis

cell differentiation

interspecies interaction between organisms

 
228927_at ZNF397 zinc finger protein 397 18 31074995, 31075016 AW291411 18q12.2 Hs.591061 8

transcription factor activity

intracellular

nucleus

cytoplasm

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
244617_at GPR26 G protein-coupled receptor 26 10 125415860 R46128 10q26.13 Hs.12751 7

receptor activity

G-protein coupled receptor activity

plasma membrane

signal transduction

G-protein coupled receptor protein signaling pathway

integral to membrane

 
65517_at -0.313 6.223 -2.971 9.404e-03 0.401 -2.504 AP1M2 adaptor-related protein complex 1, mu 2 subunit 19 -10544347 AA910946 19p13.2 Hs.18894 28

protein binding

Golgi apparatus

cytosol

protein targeting

vesicle targeting

membrane

clathrin adaptor complex

cytoplasmic vesicle

Lysosome

226944_at HTRA3 HtrA serine peptidase 3 4 8322391 AW518728 4p16.1 Hs.479119 9

regulation of cell growth

serine-type endopeptidase activity

protein binding

insulin-like growth factor binding

extracellular region

proteolysis

peptidase activity

 
1570228_at CFHR3 complement factor H-related 3 1 195010552 BC020680 1q32 Hs.575869 Hs.709217 14

extracellular region

extracellular space

 
232119_at SYNPO2 synaptopodin 2 4 120029443, 120029443 BF984227 4q26 Hs.655519 14

actin binding

protein binding

nucleus

cytoplasm

 
1558914_at PPPDE1 PPPDE peptidase domain containing 1 1 242882974 BC020640 1q44 Hs.498317 5    
219331_s_at KLHDC8A kelch domain containing 8A 1 -203572270 NM_018203 1q32.1 Hs.10414 3    
216970_at RGS7 regulator of G-protein signaling 7 1 -239005439 AF090117 1q23.1 1q43 Hs.655739 23

signal transducer activity

protein binding

cellular_component

heterotrimeric G-protein complex

intracellular signaling cascade

regulation of G-protein coupled receptor protein signaling pathway

negative regulation of signal transduction

 
205205_at -0.328 4.962 -2.418 2.861e-02 0.532 -3.442 RELB v-rel reticuloendotheliosis viral oncogene homolog B 19 50196551 NM_006509 19q13.32 Hs.654402 89

transcription factor activity

transcription corepressor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

antigen processing and presentation

myeloid dendritic cell differentiation

T-helper 1 cell differentiation

MAPK signaling pathway

226160_at H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1 9217449 AW138757 1p36 Hs.463511 25

glucose-6-phosphate dehydrogenase activity

binding

endoplasmic reticulum

endoplasmic reticulum lumen

microsome

carbohydrate metabolic process

glucose metabolic process

pentose-phosphate shunt

oxidoreductase activity

hydrolase activity

6-phosphogluconolactonase activity

glucose 1-dehydrogenase activity

oxidation reduction

Pentose phosphate pathway

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of plant hormones

Metabolic pathways

206802_at PAX5 paired box 5 9 -36828530 NM_016734 9p13 Hs.654464 58

DNA binding

nucleus

transcription from RNA polymerase II promoter

humoral immune response

multicellular organismal development

spermatogenesis

nervous system development

organ morphogenesis

cell differentiation

regulation of transcription

 
207633_s_at -0.199 2.446 -2.154 4.765e-02 0.586 -3.864 MUSK muscle, skeletal, receptor tyrosine kinase 9 112470907 NM_005592 9q31.3-q32 Hs.521653 23

nucleotide binding

transmembrane receptor protein tyrosine kinase activity

receptor activity

ATP binding

integral to plasma membrane

protein amino acid phosphorylation

transmembrane receptor protein tyrosine kinase signaling pathway

multicellular organismal development

muscle organ development

membrane

transferase activity

 
200871_s_at 0.443 10.456 2.304 3.570e-02 0.556 -3.626 PSAP prosaposin 10 -73246060 NM_002778 10q21-q22 Hs.523004 Hs.705948 76

extracellular space

lysosome

Golgi apparatus

lipid metabolic process

glycosphingolipid metabolic process

lipid transport

enzyme activator activity

lipid binding

integral to membrane

Lysosome

202363_at SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 5 -136338885 AF231124 5q31 Hs.643338 15

calcium ion binding

extracellular region

proteinaceous extracellular matrix

cell motion

cell adhesion

signal transduction

multicellular organismal development

nervous system development

cell proliferation

 
1562240_at 0.273 3.645 2.717 1.575e-02 0.459 -2.941 PLXNA4 plexin A4 7 -131820060, -131718786, -131458630 AB046770 7q32.3 Hs.511454 11

receptor activity

intracellular

signal transduction

multicellular organismal development

membrane

integral to membrane

 
1555618_s_at 0.656 6.596 2.262 3.875e-02 0.567 -3.694 SAE1 SUMO1 activating enzyme subunit 1 19 52325919, 52325954, 52325971 AF110956 19q13.32 Hs.515500 20

ubiquitin activating enzyme activity

nucleus

protein modification process

protein C-terminus binding

protein C-terminus binding

enzyme activator activity

metabolic process

protein ubiquitination

ligase activity

modification-dependent protein catabolic process

ATP-dependent protein binding

protein heterodimerization activity

Ubiquitin mediated proteolysis

227393_at ANO9 anoctamin 9 11 -407929 AW084755 11p15.5 Hs.501622 6

ion channel activity

chloride channel activity

calcium ion binding

ion transport

membrane

integral to membrane

chloride ion binding

chloride channel complex

 
220274_at IQCA1 IQ motif containing with AAA domain 1 2 -236897532 NM_024726 2q37.2-q37.3 Hs.591594 Hs.621320 Hs.711488 6

nucleotide binding

ATP binding

 
210016_at MYT1L myelin transcription factor 1-like 2 -1771891 BF223003 2p25.3 Hs.434418 Hs.669852 7

transcription factor activity

nucleus

regulation of transcription, DNA-dependent

multicellular organismal development

nervous system development

zinc ion binding

cell differentiation

metal ion binding

 
205020_s_at ARL4A ADP-ribosylation factor-like 4A 7 12693005, 12693485 NM_005738 7p21-p15.3 Hs.245540 8

nucleotide binding

GTPase activity

protein binding

GTP binding

intracellular

nucleus

nucleolus

small GTPase mediated signal transduction

 
1567013_at 0.284 4.757 2.476 2.550e-02 0.516 -3.346 NFE2L2 nuclear factor (erythroid-derived 2)-like 2 2 -177803279, -177803278 AF323119 2q31 Hs.715540 141

transcription factor activity

nucleus

cytoplasm

cytosol

regulation of transcription, DNA-dependent

transcription from RNA polymerase II promoter

sequence-specific DNA binding

protein dimerization activity

 
235643_at SAMD9L sterile alpha motif domain containing 9-like 7 -92597303 BE886225 7q21.2 Hs.489118 4    
212053_at PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 16 14976333 AK025504 16p13.11 Hs.370781 6

protein binding

lyase activity

carboxy-lyase activity

carboxylic acid metabolic process

pyridoxal phosphate binding

 
225536_at TMEM54 transmembrane protein 54 1 -33132782 AL545105 1p35-p34 Hs.534521 4

molecular_function

cellular_component

biological_process

membrane

integral to membrane

 
232717_at KALRN kalirin, RhoGEF kinase 3 125296247, 125296247, 125296247, 125786195 AU147936 3q21.2 Hs.8004 24

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

guanyl-nucleotide exchange factor activity

Rho guanyl-nucleotide exchange factor activity

ATP binding

intracellular

cytoplasm

protein amino acid phosphorylation

intracellular signaling cascade

nervous system development

actin cytoskeleton

vesicle-mediated transport

transferase activity

regulation of Rho protein signal transduction

 
213443_at TRADD TNFRSF1A-associated via death domain 16 -65745589 N36774 16q22 Hs.460996 68

signal transducer activity

cytoplasm

cytosol

cytoskeleton

induction of apoptosis

signal transduction

activation of pro-apoptotic gene products

intermediate filament binding

kinase binding

tumor necrosis factor-mediated signaling pathway

identical protein binding

positive regulation of I-kappaB kinase/NF-kappaB cascade

receptor complex

positive regulation of hair follicle development

molecular adaptor activity

death domain binding

Apoptosis

RIG-I-like receptor signaling pathway

Adipocytokine signaling pathway

211776_s_at 0.660 5.004 2.361 3.195e-02 0.545 -3.534 EPB41L3 erythrocyte membrane protein band 4.1-like 3 18 -5382387 BC006141 18p11.32 Hs.213394 39

actin binding

structural molecule activity

cytoplasm

cytoskeleton

plasma membrane

cell-cell junction

biological_process

extrinsic to membrane

cortical actin cytoskeleton organization

Tight junction

241938_at QKI quaking homolog, KH domain RNA binding (mouse) 6 163755664, 163755664 AA935633 6q26 6q26-q27 Hs.510324 Hs.593520 23

RNA binding

protein binding

nucleus

nucleolus

cytoplasm

plasma membrane

mRNA processing

regulation of translation

transport

multicellular organismal development

RNA splicing

SH3 domain binding

cell differentiation

mRNA transport

 
221272_s_at C1orf21 chromosome 1 open reading frame 21 1 182622772 NM_030806 1q25 Hs.497159 Hs.719188 8    
204059_s_at ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 6 -83976828 NM_002395 6q12 Hs.21160 24

malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity

malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity

binding

nucleus

nucleolus

cytoplasm

cytosol

carbohydrate metabolic process

malate metabolic process

NADP biosynthetic process

electron carrier activity

response to hormone stimulus

response to carbohydrate stimulus

oxidoreductase activity

manganese ion binding

ADP binding

metal ion binding

NADP or NADPH binding

NAD or NADH binding

oxidation reduction

Pyruvate metabolism

Carbon fixation in photosynthetic organisms

Biosynthesis of terpenoids and steroids

Biosynthesis of alkaloids derived from shikimate pathway

Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid

Biosynthesis of alkaloids derived from histidine and purine

Biosynthesis of alkaloids derived from terpenoid and polyketide

Metabolic pathways

PPAR signaling pathway

218358_at CRELD2 cysteine-rich with EGF-like domains 2 22 48698286 NM_024324 22q13.33 Hs.211282 9

calcium ion binding

extracellular region

endoplasmic reticulum

 
213025_at THUMPD1 THUMP domain containing 1 16 -20652489 AL134904 16p12.3 Hs.460232 5    
226975_at 0.655 6.679 2.139 4.904e-02 0.590 -3.888 RNPC3 RNA-binding region (RNP1, RRM) containing 3 1 103841165 BF116157 1p21 Hs.632423 Hs.632430 7

nucleotide binding

RNA binding

nucleus

U12-type spliceosomal complex

mRNA processing

RNA splicing

 
208436_s_at IRF7 interferon regulatory factor 7 11 -602554, -602554 NM_004030 11p15.5 Hs.166120 46

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

specific RNA polymerase II transcription factor activity

nucleus

cytoplasm

regulation of transcription, DNA-dependent

response to virus

interspecies interaction between organisms

Toll-like receptor signaling pathway

RIG-I-like receptor signaling pathway

206950_at SCN9A sodium channel, voltage-gated, type IX, alpha subunit 2 -166759942 NM_002977 2q24 Hs.439145 46

voltage-gated sodium channel complex

voltage-gated ion channel activity

voltage-gated sodium channel activity

ion transport

sodium ion transport

inflammatory response

post-embryonic development

membrane

integral to membrane

sodium ion binding

behavioral response to pain

 
230864_at MGC42105 serine/threonine-protein kinase NIM1 5 43228083 BF222940 5p12 Hs.25845 4

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

ATP binding

protein amino acid phosphorylation

transferase activity

 
215000_s_at FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 2 -36632904 AL117593 2p21 Hs.258563 9

protein binding

signal transduction

nervous system development

axon guidance

 
224571_at IRF2BP2 interferon regulatory factor 2 binding protein 2 1 -232806637 BF968057 1q42.3 Hs.693837 5

nucleus

regulation of transcription

 
202869_at OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa 12 111829121, 111829121 NM_016816 12q24.1 Hs.524760 44

nucleotide binding

RNA binding

ATP binding

nucleus

cytoplasm

mitochondrion

endoplasmic reticulum

microsome

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

immune response

transferase activity

nucleotidyltransferase activity

 
222486_s_at 0.970 5.462 2.727 1.546e-02 0.458 -2.925 ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 21 -27130476 AF060152 21q21.2 Hs.643357 44

ovulation from ovarian follicle

kidney development

metalloendopeptidase activity

protein binding

extracellular region

basement membrane

proteolysis

integrin-mediated signaling pathway

heparin binding

peptidase activity

zinc ion binding

negative regulation of cell proliferation

cytoplasmic vesicle

metal ion binding

heart trabecula formation

 
209122_at 0.746 8.438 3.965 1.215e-03 0.234 -0.765 PLIN2 perilipin 2 9 -19105758 BC005127 9p22.1 Hs.3416 31

protein binding

extracellular region

nucleus

cytoplasm

endoplasmic reticulum

lipid particle

plasma membrane

long-chain fatty acid transport

lipid storage

 
206432_at HAS2 hyaluronan synthase 2 8 -122694451 NM_005328 8q24.12 Hs.159226 26

integral to plasma membrane

membrane

transferase activity, transferring glycosyl groups

hyaluronan synthase activity

 
231271_x_at 0.560 4.905 3.904 1.375e-03 0.245 -0.870 NMRAL1 NmrA-like family domain containing 1 16 -4451695 AI080701 16p13.3 Hs.288969 8

binding

regulation of nitrogen utilization

oxidoreductase activity

transcription repressor activity

oxidation reduction

 
221253_s_at 0.443 7.692 2.974 9.339e-03 0.401 -2.498 TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 6 -7826752, -7826750 NM_030810 6p24.3 Hs.150837 12

endoplasmic reticulum

endoplasmic reticulum lumen

anti-apoptosis

isomerase activity

cell redox homeostasis

 
230009_at FAM118B family with sequence similarity 118, member B 11 125586828 AI936072 11q24.2 Hs.276315 2    
232214_x_at -0.247 6.997 -2.276 3.772e-02 0.564 -3.672 ZNF554 zinc finger protein 554 19 2770871 BC000113 19p13.3 Hs.307043 4

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
1555216_a_at LOC645722 hypothetical LOC645722 17   BC009278 17q23.2        
222934_s_at CLEC4E C-type lectin domain family 4, member E 12 -8577167 BC000715 12p13.31 Hs.236516 9

binding

sugar binding

immune response

membrane

integral to membrane

 
219068_x_at ATAD3A ATPase family, AAA domain containing 3A 1 1437417 NM_018188 1p36.33 Hs.655253 9

nucleotide binding

protein binding

ATP binding

nucleoside-triphosphatase activity

 
238633_at 0.534 6.011 2.302 3.586e-02 0.557 -3.630 EPC1 enhancer of polycomb homolog 1 (Drosophila) 10 -32597864 W93523 10p11 Hs.167805 Hs.510635 Hs.621281 16

negative regulation of transcription from RNA polymerase II promoter

histone acetyltransferase activity

nucleus

nucleoplasm

transcription activator activity

transcription repressor activity

chromatin modification

nuclear membrane

Piccolo NuA4 histone acetyltransferase complex

NuA4 histone acetyltransferase complex

regulation of growth

histone H4 acetylation

histone H2A acetylation

regulation of transcription

negative regulation of gene expression, epigenetic

positive regulation of transcription from RNA polymerase II promoter

 
1562411_at MYLK3 myosin light chain kinase 3 16 -45293694 AJ247087 16q11.2 Hs.130465 6

nucleotide binding

magnesium ion binding

myosin light chain kinase activity

ATP binding

protein amino acid phosphorylation

transferase activity

Calcium signaling pathway

Vascular smooth muscle contraction

Focal adhesion

Regulation of actin cytoskeleton

230656_s_at CIRH1A cirrhosis, autosomal recessive 1A (cirhin) 16 67723999 AL578336 16q22.1 Hs.461113 13

molecular_function

nucleus

nucleolus

biological_process

 
226161_at SLC30A6 solute carrier family 30 (zinc transporter), member 6 2 32244436 BF793552 2p22.3 Hs.23248 7

Golgi apparatus

cation transport

zinc ion transport

zinc ion binding

cation transmembrane transporter activity

membrane

integral to membrane

 
228760_at SFRS2B splicing factor, arginine/serine-rich 2B 11 94439703 AV725947 11q22 Hs.476680 Hs.713908 6

nucleotide binding

RNA binding

nucleus

mRNA processing

RNA splicing

 
221680_s_at ETV7 ets variant 7 6 -36441948 AF147782 6p21 Hs.272398 11

transcription factor activity

specific RNA polymerase II transcription factor activity

protein binding

nucleus

regulation of transcription, DNA-dependent

transcription from RNA polymerase II promoter

organ morphogenesis

sequence-specific DNA binding

Dorso-ventral axis formation

220211_at FLJ13224 hypothetical protein FLJ13224 12 31368516 NM_024799 12p11.21 Hs.505154 Hs.534485 2    
201585_s_at 0.323 7.075 3.084 7.453e-03 0.376 -2.306 SFPQ splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated) 1 -35421789 BG035151 1p34.3 Hs.355934 47

nucleotide binding

DNA binding

RNA binding

protein binding

nucleus

DNA repair

DNA recombination

mRNA processing

response to DNA damage stimulus

RNA splicing

nuclear matrix

regulation of transcription

 
206001_at -0.218 4.812 -2.370 3.145e-02 0.543 -3.521 NPY neuropeptide Y 7 24290333 NM_000905 7p15.1 Hs.1832 144

G-protein-coupled receptor binding

G-protein coupled receptor activity

neuropeptide hormone activity

calcium channel regulator activity

extracellular region

extracellular space

cell

calcium ion transport

cell motion

G-protein signaling, coupled to cyclic nucleotide second messenger

neuropeptide signaling pathway

synaptic transmission

digestion

regulation of blood pressure

cell proliferation

adult feeding behavior

positive regulation of appetite

Adipocytokine signaling pathway

216594_x_at AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 10 4995453 S68290 10p15-p14 Hs.460260 37

aldo-keto reductase activity

cytoplasm

cytosol

xenobiotic metabolic process

digestion

bile acid metabolic process

bile acid and bile salt transport

oxidoreductase activity

intestinal cholesterol absorption

carboxylic acid binding

bile acid binding

cholesterol homeostasis

response to organophosphorus

20-alpha-hydroxysteroid dehydrogenase activity

3-alpha-hydroxysteroid dehydrogenase (B-specific) activity

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

indanol dehydrogenase activity

protein homooligomerization

oxidation reduction

Metabolism of xenobiotics by cytochrome P450

215010_s_at BRSK2 BR serine/threonine kinase 2 11 1367704 AJ006701 11p15.5 Hs.170819 15

nucleotide binding

magnesium ion binding

protein serine/threonine kinase activity

ATP binding

protein amino acid phosphorylation

transferase activity

establishment of cell polarity

neuron differentiation

 
232141_at 0.368 6.465 3.110 7.068e-03 0.372 -2.261 U2AF1 U2 small nuclear RNA auxiliary factor 1 21 -43386134 AU144161 21q22.3 Hs.365116 47

nucleotide binding

nuclear mRNA splicing, via spliceosome

nuclear mRNA splicing, via spliceosome

RNA binding

protein binding

nucleus

spliceosomal complex

zinc ion binding

RNA splicing

Cajal body

metal ion binding

RS domain binding

 
1552535_at -0.206 5.611 -2.247 3.988e-02 0.568 -3.718 CLDN19 claudin 19 1 -42971350 NM_148960 1p34.2 Hs.496270 11

magnesium ion binding

structural molecule activity

plasma membrane

tight junction

visual perception

integral to membrane

basolateral plasma membrane

calcium-independent cell-cell adhesion

cell junction

identical protein binding

response to stimulus

Cell adhesion molecules (CAMs)

Tight junction

Leukocyte transendothelial migration

218676_s_at PCTP phosphatidylcholine transfer protein 17 51183354 NM_021213 17q21-q24 Hs.285218 9

cytoplasm

cytosol

cytosol

lipid binding

phosphatidylcholine transmembrane transporter activity

phosphatidylcholine transmembrane transporter activity

phospholipid transport

phosphatidylcholine binding

 
206804_at CD3G CD3g molecule, gamma (CD3-TCR complex) 11 117720268 NM_000073 11q23 Hs.2259 63

transmembrane receptor activity

plasma membrane

integral to plasma membrane

protein complex assembly

establishment or maintenance of cell polarity

cell surface receptor linked signal transduction

protein transport

receptor signaling complex scaffold activity

T cell receptor complex

T cell activation

T cell receptor binding

regulation of apoptosis

protein heterodimerization activity

Hematopoietic cell lineage

T cell receptor signaling pathway

218533_s_at UCKL1 uridine-cytidine kinase 1-like 1 20 -62041631 NM_017859 20q13.33 Hs.504998 9

nucleotide binding

uridine kinase activity

ATP binding

nucleus

cytoplasm

endoplasmic reticulum

metabolic process

kinase activity

transferase activity

phosphotransferase activity, alcohol group as acceptor

interspecies interaction between organisms

Pyrimidine metabolism

Drug metabolism - other enzymes

Metabolic pathways

223453_s_at ATL3 atlastin GTPase 3 11 -63153012 BC005096 11q12.3-q13.1 Hs.356719 4

nucleotide binding

GTPase activity

GTP binding

membrane

integral to membrane

 
211171_s_at PDE10A phosphodiesterase 10A 6 -165660767 AB026816 6q26 Hs.348762 13

nucleotide binding

magnesium ion binding

cytoplasm

signal transduction

zinc ion binding

hydrolase activity

cAMP binding

cGMP binding

3',5'-cyclic-GMP phosphodiesterase activity

Purine metabolism

224785_at FAM100B family with sequence similarity 100, member B 17 71772880 AI024869 17q25.1 Hs.719201 2    
235519_at FOXK1 forkhead box K1 7 4688455 AW007929 7p22.1 Hs.708095 10

transcription factor activity

protein binding

nucleus

nucleolus

regulation of transcription from RNA polymerase II promoter

multicellular organismal development

muscle organ development

transcription activator activity

transcription repressor activity

cell differentiation

sequence-specific DNA binding

negative regulation of transcription, DNA-dependent

positive regulation of transcription, DNA-dependent

 
215530_at FANCA Fanconi anemia, complementation group A 16 -88392267, -88331459 BG484069 16q24.3 Hs.719210 81

protein binding

nucleus

cytoplasm

DNA repair

protein complex assembly

response to DNA damage stimulus

 
213935_at ABHD5 abhydrolase domain containing 5 3 43707378 AF007132 3p21 Hs.19385 14

1-acylglycerol-3-phosphate O-acyltransferase activity

triacylglycerol lipase activity

protein binding

cytoplasm

cytosol

lipid metabolic process

fatty acid metabolic process

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

negative regulation of sequestering of triglyceride

positive regulation of triglyceride catabolic process

monolayer-surrounded lipid storage body

transferase activity

hydrolase activity

cell differentiation

lysophosphatidic acid acyltransferase activity

 
1566860_at -0.481 2.619 -4.045 1.030e-03 0.225 -0.625 LOC145663 hypothetical protein LOC145663 15   AK056979 15q15.1 Hs.75335 1    
205929_at GPA33 glycoprotein A33 (transmembrane) 1 -165288705 NM_005814 1q24.1 Hs.651244 11

receptor activity

plasma membrane

integral to plasma membrane

 
221509_at DENR density-regulated protein 12 121803323 AB014731 12q24.31 Hs.22393 6

molecular_function

translation initiation factor activity

cellular_component

translational initiation

biological_process

 
203486_s_at ARMC8 armadillo repeat containing 8 3 139388837, 139388837 BF195973 3q22.3 Hs.719108 4

binding

 
1558168_at C3orf47 chromosome 3 open reading frame 47 3 130517803 AL040547 3q21.3 Hs.450096 Hs.75307 5    
238551_at 0.271 3.746 2.654 1.787e-02 0.475 -3.047 FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 10 75202054 BF541967 10q22.2 Hs.588854 4

Golgi membrane

Golgi apparatus

protein amino acid glycosylation

membrane

integral to membrane

transferase activity, transferring glycosyl groups

alpha(1,3)-fucosyltransferase activity

 
224533_s_at C6orf142 chromosome 6 open reading frame 142 6 53991672 M77498 6p12.1 Hs.382212 Hs.591803 10    
212807_s_at SORT1 sortilin 1 1 -109653714 BF447105 1p21.3-p13.1 Hs.485195 Hs.703487 47

ossification

receptor activity

nucleus

lysosome

early endosome

endoplasmic reticulum

microsome

Golgi apparatus

plasma membrane

coated pit

transport

Golgi to endosome transport

endocytosis

neuropeptide signaling pathway

multicellular organismal development

endosome to lysosome transport

induction of apoptosis by extracellular signals

cell surface

nerve growth factor receptor activity

regulation of gene expression

myotube differentiation

integral to membrane

cytoplasmic membrane-bounded vesicle

vesicle organization

enzyme binding

clathrin-coated vesicle

cell differentiation

neurotensin receptor activity, non-G-protein coupled

endosome transport via multivesicular body sorting pathway

response to insulin stimulus

negative regulation of apoptosis

glucose import

nerve growth factor receptor signaling pathway

plasma membrane to endosome transport

nerve growth factor binding

perinuclear region of cytoplasm

negative regulation of lipoprotein lipase activity

Lysosome

Neurotrophin signaling pathway

234583_at CHL1 cell adhesion molecule with homology to L1CAM (close homolog of L1) 3 213649 AL359583 3p26.1 Hs.148909 11

protein binding

extracellular region

proteinaceous extracellular matrix

plasma membrane

cell adhesion

signal transduction

multicellular organismal development

nervous system development

integral to membrane

cell differentiation

 
228561_at CDC37L1 cell division cycle 37 homolog (S. cerevisiae)-like 1 9 4669565 BF510563 9p24.1 Hs.561954 6

protein binding

cytoplasm

 
36475_at GCAT glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A ligase) 22 36533900 Z97630 22q13.1 Hs.54609 6

mitochondrion

mitochondrial inner membrane

cellular amino acid metabolic process

acyltransferase activity

glycine C-acetyltransferase activity

biosynthetic process

transferase activity, transferring nitrogenous groups

pyridoxal phosphate binding

Glycine, serine and threonine metabolism

1567270_at OR4C1P olfactory receptor, family 4, subfamily C, member 1 pseudogene 11   X64985 11q11 Hs.550274 1    
233461_x_at 0.712 5.286 3.197 5.918e-03 0.357 -2.110 ZNF226 zinc finger protein 226 19 49361088, 49361088, 49361096, 49361156 AK023091 19q13.2 Hs.145956 6

DNA binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
200680_x_at HMGB1 high-mobility group box 1 13 -29930878 NM_002128 13q12 Hs.593339 Hs.596078 Hs.644368 157

condensed chromosome

nucleus

nucleolus

DNA unwinding during replication

DNA repair

base-excision repair, DNA ligation

DNA recombination

chromatin organization

regulation of transcription from RNA polymerase II promoter

anti-apoptosis

signal transduction

transcription factor binding

DNA bending activity

negative regulation of transcriptional preinitiation complex assembly

Base excision repair

226895_at NFIC nuclear factor I/C (CCAAT-binding transcription factor) 19 3310615, 3317572 AW134798 19p13.3 Hs.170131 23

negative regulation of transcription from RNA polymerase II promoter

transcription factor activity

intracellular

nucleus

DNA replication

regulation of transcription, DNA-dependent

positive regulation of transcription from RNA polymerase II promoter

 
213995_at ATP5S ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) 14 49848796, 49848796 AW195882 14q21.3 Hs.438489 12

mitochondrion

mitochondrial inner membrane

ATP biosynthetic process

ion transport

hydrogen ion transmembrane transporter activity

proton transport

membrane

proton-transporting ATP synthase complex, coupling factor F(o)

 
203570_at 1.063 4.863 4.166 8.048e-04 0.214 -0.417 LOXL1 lysyl oxidase-like 1 15 72005841 NM_005576 15q22 15q24-q25 Hs.65436 48

copper ion binding

protein binding

extracellular region

proteinaceous extracellular matrix

extracellular space

oxidoreductase activity

oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

protein amino acid deamination

metal ion binding

oxidation reduction

 
223414_s_at LYAR Ly1 antibody reactive homolog (mouse) 4 -4320331, -4320331 AL136750 4p16.3 Hs.425427 14

protein binding

nucleus

nucleolus

zinc ion binding

metal ion binding

 
209062_x_at NCOA3 nuclear receptor coactivator 3 20 45564063 AF010227 20q12 Hs.592142 140

transcription coactivator activity

histone acetyltransferase activity

signal transducer activity

nucleus

cytoplasm

signal transduction

acyltransferase activity

transferase activity

androgen receptor signaling pathway

transcription regulator activity

positive regulation of transcription, DNA-dependent

thyroid hormone receptor binding

protein N-terminus binding

androgen receptor binding

 
208836_at 0.367 7.577 2.371 3.138e-02 0.543 -3.519 ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 3 143078159 U51478 3q23 Hs.477789 13

sodium:potassium-exchanging ATPase activity

protein binding

cytoplasm

sodium:potassium-exchanging ATPase complex

ATP biosynthetic process

ion transport

potassium ion transport

sodium ion transport

membrane

integral to membrane

potassium ion binding

sodium ion binding

melanosome

Cardiac muscle contraction

226436_at 0.689 6.226 2.418 2.862e-02 0.532 -3.442 RASSF4 Ras association (RalGDS/AF-6) domain family member 4 10 44775224 N49935 10q11.21 Hs.522895 9

protein binding

cell cycle

signal transduction

 
207078_at MED6 mediator complex subunit 6 14 -70120709 NM_005466 14q24.2 Hs.497353 22

RNA polymerase II transcription factor activity

transcription coactivator activity

nucleus

RNA polymerase II transcription mediator activity

regulation of transcription

positive regulation of transcription from RNA polymerase II promoter

 
223297_at 0.380 7.139 2.239 4.051e-02 0.570 -3.731 AMMECR1L AMME chromosomal region gene 1-like 2 -128335675 BC004208 2q21 Hs.546449 3    
218626_at EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 22 -30165354 NM_019843 22q11.2 Hs.517559 15

protein binding

nucleus

cytoplasm

protein transporter activity

protein transport

 
215640_at TBC1D2B TBC1 domain family, member 2B 15 -76074381 AK000173 15q24.3-q25.1 Hs.719242 2

GTPase activator activity

Rab GTPase activator activity

intracellular

regulation of Rab GTPase activity

 
200810_s_at CIRBP cold inducible RNA binding protein 19 1220266, 1220266 NM_001280 19p13.3 Hs.634522 Hs.664127 17

nucleotide binding

RNA binding

protein binding

nucleus

nucleoplasm

response to cold

 
1568828_at LOC730441 similar to trypsin X5 7   BC039387 7q34 Hs.604069 1    
218645_at ZNF277 zinc finger protein 277 7 111633878 NM_021994 7q31.1 Hs.655904 10

transcription factor activity

protein binding

intracellular

nucleus

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
213566_at 0.546 3.497 2.164 4.678e-02 0.583 -3.849 RNASE6 ribonuclease, RNase A family, k6 14 20319049 NM_005615 14q11.2 Hs.23262 6

nucleic acid binding

endonuclease activity

pancreatic ribonuclease activity

ribonuclease activity

extracellular region

RNA catabolic process

defense response

hydrolase activity

 
229758_at TIGD5 tigger transposable element derived 5 8 144751363 AW168771 8q24.3 Hs.71574 4

chromosome, centromeric region

DNA binding

nucleus

regulation of transcription

 
1552299_at AKD1 adenylate kinase domain containing 1 6 -110059592, -109920751 NM_145025 6q21 Hs.205144 Hs.335027 Hs.486169 6

ATP binding

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

nucleobase, nucleoside, nucleotide kinase activity

 
1560553_at TIAF1 TGFB1-induced anti-apoptotic factor 1 17 -24424664 BC011938 17q11.2 Hs.462590 15

molecular_function

nucleus

apoptosis

anti-apoptosis

I-kappaB kinase/NF-kappaB cascade

 
212775_at OBSL1 obscurin-like 1 2 -220123708 AI978623 2q35 Hs.526594 10

cytoskeleton organization

cytoskeletal adaptor activity

intercalated disc

Z disc

M band

perinuclear region of cytoplasm

cardiac myofibril assembly

 
210398_x_at FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 19 -5781636 M98825 19p13.3 Hs.631846 Hs.705615 19

Golgi apparatus

protein amino acid glycosylation

membrane

integral to membrane

transferase activity, transferring glycosyl groups

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity

L-fucose catabolic process

alpha(1,3)-fucosyltransferase activity

Glycosphingolipid biosynthesis - lacto and neolacto series

Metabolic pathways

220403_s_at TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 11 -128310479 NM_022112 11q24 Hs.160953 Hs.711194 11

molecular_function

mitochondrion

apoptosis

p53 signaling pathway

223968_at ZNF44 zinc finger protein 44 19 -12243624 BC001868 19p13.2 Hs.296731 Hs.693933 10

DNA binding

protein binding

intracellular

nucleus

cytoplasm

cytoskeleton

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
226312_at 0.480 7.938 3.036 8.238e-03 0.387 -2.392 RICTOR RPTOR independent companion of MTOR, complex 2 5 -38973779 BF940270 5p13.1 Hs.407926 21

guanyl-nucleotide exchange factor activity

protein binding

intracellular

embryonic development

positive regulation of actin filament polymerization

actin cytoskeleton reorganization

TORC2 complex

positive regulation of TOR signaling pathway

regulation of Rac GTPase activity

regulation of actin cytoskeleton organization

positive regulation of peptidyl-tyrosine phosphorylation

regulation of small GTPase mediated signal transduction

regulation of protein kinase B signaling cascade

mTOR signaling pathway

237847_at NTN1 netrin 1 17 8865583 BF058964 17p13-p12 Hs.660885 29

neuron migration

protein binding

extracellular region

basement membrane

cytoplasm

apoptosis

axon guidance

positive regulation of cell proliferation

regulation of cell migration

negative regulation of axon extension

mammary gland development

establishment of nucleus localization

positive regulation of axon extension

Axon guidance

234220_at CADPS Ca++-dependent secretion activator 3 -62359061 AK024536 3p14.2 Hs.654933 14

calcium ion binding

cytosol

exocytosis

lipid binding

protein transport

membrane

cell junction

cytoplasmic vesicle

synapse

 
239314_at NHLRC3 NHL repeat containing 3 13 38510454 AV688972 13q13.3 Hs.507783 1

extracellular region

 
201234_at 0.388 7.620 2.719 1.569e-02 0.459 -2.937 ILK integrin-linked kinase 11 6581539, 6581782 NM_004517 11p15.5-p15.4 Hs.5158 Hs.706355 115

nucleotide binding

branching involved in ureteric bud morphogenesis

protein serine/threonine kinase activity

protein tyrosine kinase activity

protein binding

ATP binding

cytoplasm

plasma membrane

focal adhesion

protein amino acid phosphorylation

cell-matrix adhesion

integrin-mediated signaling pathway

positive regulation of cell proliferation

regulation of signal transduction

transferase activity

cell junction

establishment or maintenance of epithelial cell apical/basal polarity

PPAR signaling pathway

Focal adhesion

Endometrial cancer

238813_at ALAS2 aminolevulinate, delta-, synthase 2 X -55052213 AI910842 Xp11.21 Hs.522666 Hs.555936 29

response to hypoxia

5-aminolevulinate synthase activity

protein binding

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

porphyrin metabolic process

heme biosynthetic process

heme biosynthetic process

cellular iron ion homeostasis

acyltransferase activity

glycine binding

transferase activity, transferring nitrogenous groups

pyridoxal phosphate binding

erythrocyte differentiation

erythrocyte differentiation

oxygen homeostasis

tetrapyrrole biosynthetic process

hemoglobin biosynthetic process

coenzyme binding

Glycine, serine and threonine metabolism

Porphyrin and chlorophyll metabolism

Metabolic pathways

1554985_at ZNF396 zinc finger protein 396 18 -31200658 BC031580 18q12 Hs.351005 3

transcription factor activity

intracellular

nucleus

cytoplasm

regulation of transcription, DNA-dependent

zinc ion binding

metal ion binding

 
239040_at HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 4 -83493490 AW967813 4q21.1-q21.2 Hs.480073 64

nucleotide binding

nuclear mRNA splicing, via spliceosome

DNA binding

RNA binding

RNA binding

protein binding

nucleus

chromosome

regulation of transcription, DNA-dependent

RNA processing

RNA catabolic process

biological_process

transcription activator activity

heterogeneous nuclear ribonucleoprotein complex

telomeric DNA binding

 
202868_s_at POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 19 34789009 NM_006627 19q12 Hs.412870 13

ribonuclease MRP complex

RNA binding

ribonuclease P activity

ribonuclease activity

nucleus

nucleolar ribonuclease P complex

nucleolus

rRNA processing

mRNA cleavage

tRNA processing

hydrolase activity

ribonuclease P complex

identical protein binding

 
223789_s_at GTPBP2 GTP binding protein 2 6 -43696195 AF116627 6p21-p12 Hs.485449 7

nucleotide binding

GTPase activity

GTP binding

 
220925_at MAK10 MAK10 homolog, amino-acid N-acetyltransferase subunit (S. cerevisiae) 9 87745876 NM_021929 9q21.33 Hs.436098 7

protein binding

cytoplasm

smooth muscle cell proliferation

 
1554068_s_at C12orf66 chromosome 12 open reading frame 66 12 -62872685 BC036246 12q14.2 Hs.505871 3    
240289_at LOC100131683 hypothetical protein LOC100131683 4   W86910 4q35.1 Hs.442702      
200851_s_at 0.221 8.609 2.178 4.557e-02 0.581 -3.828 KIAA0174 KIAA0174 16 70486946 NM_014761 16q22.2 Hs.232194 14

protein binding

ER-Golgi intermediate compartment

cell cycle

cytoplasmic vesicle

cell division

 
210563_x_at 0.642 8.039 2.447 2.698e-02 0.525 -3.393 CFLAR CASP8 and FADD-like apoptosis regulator 2 201689060, 201689134, 201691631 U97075 2q33-q34 Hs.390736 163

cysteine-type endopeptidase activity

protein binding

proteolysis

anti-apoptosis

induction of apoptosis by extracellular signals

regulation of apoptosis

positive regulation of I-kappaB kinase/NF-kappaB cascade

interspecies interaction between organisms

Apoptosis

227317_at LMCD1 LIM and cysteine-rich domains 1 3 8518510 AA045042 3p26-p24 Hs.475353 4

negative regulation of transcription from RNA polymerase II promoter

molecular_function

transcription corepressor activity

protein binding

cellular_component

nucleus

biological_process

zinc ion binding

metal ion binding

 
214693_x_at NBPF10 neuroblastoma breakpoint family, member 10 1 144004727 BE732345 1q21.1 Hs.515947 6

cytoplasm

 
1560399_a_at OTUD7A OTU domain containing 7A 15 -29562620 BC035668 15q13.3 Hs.355236 2

DNA binding

nucleus

cytoplasm

peptidase activity

cysteine-type peptidase activity

zinc ion binding

modification-dependent protein catabolic process

metal ion binding

 
1556414_at 0.480 5.360 3.042 8.127e-03 0.387 -2.380 C21orf71 chromosome 21 open reading frame 71 21 -25876958 BU192089 21q21.3 Hs.384586      
222386_s_at 0.251 8.732 2.325 3.428e-02 0.553 -3.593 COPZ1 coatomer protein complex, subunit zeta 1 12 53005177 AB047848 12q13.2-q13.3 Hs.505652 14

protein binding

cytoplasm

Golgi apparatus

cytosol

intracellular protein transport

retrograde vesicle-mediated transport, Golgi to ER

retrograde vesicle-mediated transport, Golgi to ER

intra-Golgi vesicle-mediated transport

intra-Golgi vesicle-mediated transport

membrane

membrane organization

vesicle-mediated transport

membrane coat

COPI vesicle coat

COPI vesicle coat

cytoplasmic vesicle

COPI coating of Golgi vesicle

 
219481_at TTC13 tetratricopeptide repeat domain 13 1 -229108611 NM_024525 1q42.2 Hs.424788 5

binding

 
226370_at KLHL15 kelch-like 15 (Drosophila) X -23911756 BG149487 Xp22.1-p21 Hs.495854 6

protein binding

modification-dependent protein catabolic process

 
214314_s_at EIF5B eukaryotic translation initiation factor 5B 2 99320265 BE138647 2q11.2 Hs.158688 15

nucleotide binding

translation initiation factor activity

translation initiation factor activity

GTPase activity

protein binding

GTP binding

cytoplasm

translation

regulation of translational initiation

regulation of translational initiation

 

4270 Genes