| Primary Expertise |
|---|
| Dr. Barker is the Director Emeritus of Protein Information Resource at the National
Biomedical Research Foundation. Her primary responsibility is to oversee scientific
content of PIR databases. Her research interest is the classification of proteins
into superfamilies.
|
| Honors |
|---|
| 1996 |
A Pehr Edman Award, Millipore/Methods in Protein Structure
Analysis |
| Education |
|---|
 |
B.A., Zoology, Connecticut
College, New London, CT. 1959 |
|
Ph.D., Physiology, University
of Chicago, Chicago, IL. 1966 |
|
Post-Doc, Mathematical Biology, University
of Chicago, Chicago, IL. 1967 |
| Publications |
|---|
| UniProt Consortium (2007). The Universal Protein Resource (UniProt).
Nucleic Acids Res. 35(Database issue):D193-197. |
| Natale D.A., Arighi C.N., Barker W.C., Blake J., Chang T., Hu Z.Z., Liu
H., Smith B., Wu C.H. (2006). Framework for a Protein Ontology
Proceedings of ACM First International Workshop on Text Mining in Bioinformatics, TMBIO 2006. |
| Nikolskaya A.N., Arighi C.N., Huang H., Barker W.C., Wu C.H. (2006). PIRSF Family Classification System for Protein Functional and Evolutionary Analysis.
Evolutionary Bioinformatics Online 2, 209-221. |
| Wu, C.H., Apweiler, R., Bairoch, A., Natale, D.A., Barker, W.C., Boeckmann, B., Ferro, S.,
Gasteiger, E., Huang, H., Lopez, R., Magrane, M., Martin, M.J., Mazumder, R., O'donovan, C.,
Redaschi, N., Suzek, B. (2006). The Universal Protein Resource (UniProt): an expanding universe of protein
information.
Nucleic Acids Research, 34, D187-91. |
|
Bairoch, A., Apweiler, R., Wu, C. H., Barker, W. C., Boeckmann, B., Ferro, S., Gasteiger, E., Huang, H., Lopez, R., Magrane, M., Martin, M.J., Natale, D.A., O'Donovan, C., Redaschi, N., Yeh, L.S. (2005).
The Universal Protein Resource (UniProt). Nucleic Acids Research, 33: D154-159.
|
| Wu, C.H., Huang, H., Nikolskaya, A., Hu, Z. and Barker, W. C. (2004). The iProClass integrated database for protein functional analysis. Computational Biology and Chemistry, 28, 87-96.
|
| Wu, C. H., Nikolskaya, A., Huang, H., Yeh, L.-S., Natale, D., Vinayaka, C. R., Hu, Z.,
Mazumder, R., Kumar, S., Kourtesis, P., Ledley, R. S., Suzek, B. E., Arminski, L., Chen, Y.,
Zhang, J., Cardenas, J. L., Chung, S., Castro-Alvear, J., Dinkov, G. and Barker, W. C. (2004).
PIRSF family classification
system at the Protein Information Resource.
Nucleic Acids Research, 32, D112-114.
|
| Apweiler R, Bairoch A, Wu, C. H., Barker, W. C., Boeckmann, B., Ferro1, S., Gasteiger, E.,
Huang, H., Lopez, R., Magrane, M., Martin, M. J., Natale, D. A., O Donovan, C., Redaschi, N.,
Yeh, L. S. (2004).
UniProt: Universal Protein
Knowledgebase. Nucleic Acids Research, 32, D115-119.
|
| Wu, C. H., Yeh, L.-S., Huang, H., Arminski, L., Castro-Alvear, J., Chen, Y., Hu, Z.,
Kourtesis, P., Ledley, R. S., Suzek, B.E., Vinayaka, C.R., Zhang, J. and Barker, W. C. (2003).
The Protein
Information Resource. Nucleic Acids Research, 31, 345-347.
|
| Huang, H., Barker, W. C., Chen, Y. and Wu, C. H.(2003).
iProClass:
An Integrated Database of Protein Family, Function, and Structure Information.
Nucleic Acids Research, 31, 390-392.
|
| Wu, C. H., Huang, H., Yeh, L.-S. and Barker, W. C. (2003).
Protein family
classification and functional annotation.
Computational Biology and Chemistry, 27, 37-47.
|
| Wu, C.H., Huang, H., Arminski, L., Castro-Alvear, J., Chen, Y., Hu,Z. Z., Ledley, R. S., Lewis, K. C., Mewes, H., Orcutt, B. C., Suzek, B. E., Tsugita, A., Vinayaka, C. R., Yeh, L. S., Zhang, J., Barker, W. C. (2002).
The Protein Information Resource: an integrated public resource of functional annotation of proteins.
Nucleic Acids Research, 30, 35-37.
|
| Barker, W. C., et al. and C. H. Wu. (2001).
The Protein Information Resource. Nucleic Acids Research, 29, 29-32.
|
| Wu, C., Xiao, C., Hou, Z., Huang, H., Barker,
W.C. Nucleic Acids Res.(2001)
iProclass:
an integrated, comprehensive and annotated protein classification database.29,
52-54.
|
| E.E. Abola, A. Bairoch, W.C.
Barker, et.al. (2000) Quality Control in Databanks for
Molecular Biology, BioEssays.
|
| Barker, W. C., et al. and C. H. Wu. (2000).
The Protein Information Resource. Nucleic Acids Research, 28,
41-44.
|
| P.B. McGarvey, H. Huang, W.C.
Barker, B.C. Orcutt, J.S. Garavelli, G.Y. Srinivasarao,
L-S.L. Yeh, C. Xiao, and C.H. Wu. (2000) PIR:
a new resource for bioinformatics, Bioinformatics, 16: 290-291.
|
| G.Y. Srinivasarao, L.-S.L. Yeh, C.R. Marzec, B.C.
Orcutt, and W.C. Barker (1999) PIR-ALN:
A Database of Protein Sequence Alignments, Bioinformatics, 15: 382-390.
|
| G.Y. Srinivasarao, L-S.L. Yeh, C.R. Marzec, B.C.
Orcutt, W.C. Barker, and F. Pfeiffer. (1999) Database
of protein sequence alignments: PIR-ALN, Nucleic Acids Research, 27: 284-285.
|
| W.C. Barker, J.S. Garavelli, P.B. McGarvey,
C.R. Marzec, B.C. Orcutt, G.Y. Srinivasarao, L-S.L. Yeh, R.S. Ledley, H.-W.
Mewes, F. Pfeiffer and A. Tsugita (1999) The
PIR-International Protein Sequence Database, Nucleic Acids Research, 27:
39-43.
|
| C. Wu, S. Zhao and W.C. Barker, (1997) Family
Identification System for Electron Transfer Proteins Using a Motif Neural
Network Design, Pept. Lett., 4: 279-285.
|
| W.C. Barker, F. Pfeiffer and D.G. George (1996)
The Superfamily Classification in the PIR-International Protein Sequence
Database, Methods in Enzymology, R.F. Doolittle, ed., Academic Press,
Orlando, FL. pp. 59-71.
|
|
W.C. Barker, F. Pfeiffer, and
D.G. George (1995) Superfamily and Domain: Organization of Data for Molecular
Evolution Studies, Methods in Protein Structure and Analysis.
M.Z. Atassi and E. Appella, eds., Plenum Publishing, New York, pp. 473-481.
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Revised 07/13/07
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