Honors
1996	Recipient of National Institutes of Health Fellows Award for Research Excellence (FARE), Bethesda, MD
1993-1998	Recipient of Intramural Research Training Award, National Institutes of Health, Bethesda, MD

Education
	M.D., Medicine, Wannan Medical College, Wuhu, Anhu, China, 1984
	M.S., Physiology, Beijing Medical University, Beijing, China, 1989

Publications
Hu ZZ, Cohen KB, Hirschman L, Valencia A, Liu H, Giglio MG, Wu CH. iProLINK: A Framework for Linking Text Mining with Ontology and Systems Biology. In Proceedings of IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2008), Philadelphia, 2008
Hu ZZ, Huang H, Cheema A, Jung M, Dritschilo A, Wu CH. (2008) Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data. J Proteomics & Bioinformatics 1(2):047-060.
Torii M, Hu ZZ, Song M, Wu CH, Liu H. (2007) A Comparison study on algorithms of detecting long forms for short forms in biomedical text. BMC Bioinformatics, 8 Suppl 9:S5
Natale DA, Arighi CN, Barker W, Blake J, Chang TC, Hu ZZ, Liu H, Smith B, Wu CH. (2007) Framework for a Protein Ontology. BMC Bioinformatics, 8 Suppl 9:S1
Huang H, Hu ZZ, Arighi CN, Wu CH. (2007) Integration of bioinformatics resources for functional analysis of gene expression and proteomic data. Frontiers in Bioscience, 12:5071-5088
Mazumder R, Hu ZZ, Vinayaka CR, Sagripanti JL, Frost SDW, Kosakovsky Pond SL, Wu CH (2007). Computational Identification of Functional Amino Acid Sites of E Glycoproteins of Dengue Viruses. Virus Genes, 35:175-186
Torii M, Liu HF, Hu ZZ and Wu, C.H. (2006) A comparison study of biomedical short form definition detection algorithms. Proceedings of ACM First International Workshop on Text Mining in Bioinformatics, TMBIO 2006.
Natale DA, Arighi CN, Barker W, Blake J, Chang T, Hu ZZ, Liu H, Smith B, Wu CH. (2006) Framework for a Protein Ontology Proceedings of ACM First International Workshop on Text Mining in Bioinformatics, TMBIO 2006.
Qiu P, Wang J, Ray Liu KJ, Hu ZZ, Wu CH. (2007) Dependence network modeling for biomarker identification. Bioinformatics 23:198-206.
Hu ZZ, Valencia JC, Huang H, Chi A, Shabanowitz J, Hearing VJ, Appella E, Wu CH. (2007) Comparative bioinformatics analyses and profiling of lysosome-related organelle proteomes. Int J Mass Spec 259:147-160
Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF. (2006) Proteomic and Bioinformatic Characterization of the Biogenesis and Function of Melanosomes. J Proteome Res 5:3135-3144.
Han B, Obradovic Z, Hu ZZ, Wu CH, Vucetic S. (2006) Substring selection for biomedical document classification. Bioinformatics 22:2136-42.
Liu H, Hu ZZ, Torii M, Wu C, Friedman C. (2006) Quantitative Assessment of Dictionary-based Protein Named Entity Tagging. J Am Med Inform Assoc 13:497-507.
Yuan X, Hu ZZ, Wu HT, Torii M, Narayanaswamy M, Ravikumar KE, Vijay-Shanker K, and Wu CH. (2006) An Online Literature Mining Tool for Protein Phosphorylation. Bioinformatics 22:1668-9.
Liu H, Hu ZZ, Wu CH (2006). BioThesaurus: a web-based thesaurus of protein and gene names. Bioinformatics 22: 103-105.
Liu H, Hu ZZ, Wu CH (2005). DynGO: a tool for visualizing and mining of Gene Ontology and its associations. BMC Bioinformatics 6: 201.
Mani I, Hu Z, Jang SB, Samuel K, Krause M, Phillips J, Wu CH (2005). Protein name tagging guidelines: lessons learned. Comparative and Functional Genomics 6(1-2): 72-76.
Hu ZZ, Narayanaswamy M, Ravikumar KE, Vijay-Shanker K, Wu CH (2005). Literature Mining and Database Annotation of Protein Phosphorylation Using a Rule-Based System. Bioinformatics 21(11): 2759-2765.
Hu ZZ, Mani I, Hermoso V, Liu H and Wu CH (2004). iProLINK: an integrated protein resource for literature mining. Comput Biol Chem 28: 409-416.
Huang H, Hu ZZ, Suzek BE and Wu CH (2004). The PIR integrated protein databases and data retrieval system. Data Sci J 3: 163-174.
Wu CH, Huang H, Nikolskaya A, Hu ZZ and Barker WC (2004). The iProClass integrated database for protein functional analysis. Comput Biol Chem 28: 87-96.
Mani I, Hu ZZ, Jang S, Samuel K, Krause M, Phillips J and Wu C (2004). Protein Name Tagging Guidelines: Lessons Learned. ISMB BioLINK SIG, Intelligent Systems for Molecular Biology, Glasgow, 29 July, to appear in: Comparative and Functional Genomics.
Wu CH, Nikolskaya A, Huang H, Yeh LS, Natale DA, Vinayaka CR, Hu ZZ, Mazumder R, Kumar S, Kourtesis P, Ledley RS, Suzek BE, Arminski L, Chen Y, Zhang J, Cardenas JL, Chung S, Castro-Alvear J, Dinkov G and Barker WC (2004). PIRSF: family classification system at the Protein Information Resource. Nucleic Acids Res 32 Database issue: D112-4.
Wu CH, Yeh LS, Huang H, Arminski L, Castro-Alvear J, Chen Y, Hu ZZ, Kourtesis P, Ledley RS, Suzek BE, Vinayaka CR, Zhang J, Barker WC (2003). The Protein Information Resource. Nucleic Acids Res 31: 345-7.
Leondires MP, Hu ZZ, Dong J, Tsai-Morris CH and Dufau ML (2002). Estradiol stimulates expression of two human prolactin receptor isoforms with alternative exons-1 in T47D breast cancer cells. J Steroid Biochem Mol Biol 82: 263-8.
Hu ZZ, Zhuang L, Meng JP, Tsai-Morris CH and Dufau ML (2002). Complex 5' genomic structure of the human prolactin receptor: multiple alternative exons 1 and promoter utilization. Endocrinology 143: 2139-42.
Wu CH, Huang H, Arminski L, Castro-Alvear L, Chen Y, Hu ZZ, Ledley RS, Lewis KC, Mewes HW, Orcutt BC, Suzek BE, Tsugita A, Vinayaka CR, Yeh LSL, Zhang J and Barker WC (2002). The Protein Information Resource: an integrated public resource of functional annotation of proteins. Nucl Acids Res 30: 35-37.
Hu ZZ, Meng JP, and Dufau ML (2001). Isolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11. J Biol Chem 276: 41086-41094.
Hu ZZ, Zhuang L, Meng JP, Leondires M and Dufau ML (1999). The human prolactin receptor gene structure and alternative promoter utilization: the generic promoter hPIII and a novel human promoter hPN. J Clin Endocrinol Metab 84: 1153-1156.
Hu ZZ, Zhuang L, Meng JP and Dufau ML (1998). Transcriptional regulation of the generic promoter III of the rat prolactin receptor gene by C/EBPb and Sp1 transcription factors. J Biol Chem 273: 26225-26235.
Hu ZZ, Zhuang L, Dufau ML (1998). Prolactin receptor gene diversity: structure and regulation. Trends in Endocrinol Metab 9: 94-102.
Ma W, Zhang L, Xing G, Hu ZZ, Iwasa KH, Clay JR (1998). Prenatal expression of inwardly rectifying potassium channel mRNA (Kir4.1) in rat brain. NeuroReport 9: 223-227.
Hu ZZ, Zhuang L, Guan XY, Meng JP and Dufau ML (1997). Steroidogenic factor 1 is an essential transcriptional activator for the gonadal-specific expression of promoter I of the prolactin receptor. J Biol Chem 272: 14263-14271.
Hu ZZ, Zhuang L and Dufau ML (1996). Multiple and tissue-specific promoter control of gonadal and non-gonadal prolactin receptor gene expression. J Biol Chem 271: 10242-10246.
Dufau ML, Tsai-Morris CH, Hu ZZ and Buczko E (1995). Structure and regulation of the luteinizing hormone receptor gene. J Steroid Biochem Mol Biol 53: 283-91
Hu ZZ, Buczko E, Zhuang L, and Dufau ML (1994). Sequence of the 3'-noncoding region of the luteinizing hormone receptor gene and identification of two polyadenylation domains that generate the major mRNA forms. BBA Mol. Cell. Res. 1220: 333-337.
Dufau ML, Tsai-Morris C-H, Hu ZZ, Geng Y, Xie X, Zhuang L, Zhang R,and Buczko E (1994) The luteinizing hormone receptor. In: Dufau ML, Fabbri A, Isidori A, eds. Frontiers in Endocrinology: Cell and Molecular Biology of the Testis. Serono Symposia Publications pp51-60.
Dufau ML, Tsai-Morris CH, Hu ZZ, Wang W, Zhang R, Xie X and Buczko E (1992). Gonadal LH and prolactin receptor characterization: molecular structure and hormonal regulation of receptor mRNA. In: Spera G, Fabbrini A, Gnessi L, Bardin CW, eds. Molecular and Cellular Biology of Reproduction. New York: Serono Symposia Publications, Raven Press. 90: 47-61.
Hu ZZ and Dufau ML (1991). Multiple and differential regulation of ovarian prolactin receptor messenger RNAs and their expression. Biochem Biophys Res Commun 181: 219-25.
Hu ZZ, Tsai-Morris CH, Buczko E and Dufau ML (1990) Hormonal regulation of LH receptor mRNA and expression in the rat ovary. FEBS Lett 274: 181-4.
Zhang R, Buczko E, Tsai-Morris CH, Hu ZZ and Dufau ML (1990) Isolation and characterization of two novel rat ovarian lactogen receptor cDNA species Biochem Biophys Res Commun 168: 415-22.

Revised 11/17/08